Manioc : Portail | resultats 1 - 1 pour la recherche: This work was supported by grants from the National Institute of Health and Medical Research (INSERM) n°A03136GS, the National Research Agency (ANR) n°R06001NG, the French Agency for Environmental and Occupational Health Safety (AFSSET) n°R08015NN, the n°R09074NN, the n°R01002GG, the French Institute for Public Health Surveillance (InVS) n°R06013NG. The authors declare they have no actual or potential competing financial interests.

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Prenatal exposure to persistent organic pollutants and organophosphate pesticides, and markers of glucose metabolism at birth
Auteur(s) : Debost-Legrand, Anne Warembourg, Charline Massart, Catherine Chevrier, Cécile Bonvallot, Nathalie Monfort, Christine Rouget, Florence Bonnet, Fabrice
Auteurs secondaires : Périnatalité, grossesse, Environnement, PRAtiques médicales et DEveloppement (PEPRADE) ; CHU Clermont-Ferrand - Université d'Auvergne - Clermont-Ferrand I (UdA) Service de Génétique Médicale ; CHU Clermont-Ferrand - Université de Clermont-Ferrand Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) Centre d'Investigation Clinique [Rennes] (CIC) ; Université de Rennes 1 (UR1) - Hôpital Pontchaillou - Institut National de la Santé et de la Recherche Médicale (INSERM) École des Hautes Études en Santé Publique [EHESP] (EHESP) Centre de recherche en épidémiologie et santé des populations (CESP) ; Université de Versailles Saint-Quentin-en-Yvelines (UVSQ) - Université Paris-Sud - Paris 11 (UP11) - Assistance publique - Hôpitaux de Paris (AP-HP) - Hôpital Paul Brousse - Institut National de la Santé et de la Recherche Médicale (INSERM) CHU Pontchaillou [Rennes] This work was supported by grants from the National Institute of Health and Medical Research (INSERM) n°A03136GS, the National Research Agency (ANR) n°R06001NG, the French Agency for Environmental and Occupational Health Safety (AFSSET) n°R08015NN, the n°R09074NN, the n°R01002GG, the French Institute for Public Health Surveillance (InVS) n°R06013NG. The authors declare they have no actual or potential competing financial interests.

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Background Experimental evidence suggests that developmental exposure to persistent organic pollutants (POP) and to some non persistent pesticides may disrupt metabolic regulation of glucose metabolism and insulin secretion, and thereby contribute to the current epidemic of obesity and metabolic disorders. Quasi-experimental situations of undernutrition in utero have provided some information. However, the evidence in humans concerning the role of the prenatal environment in these disorders is contradictory, and little is known about long-term outcomes, such as type 2 diabetes, of prenatal exposure. Objectives Our aim was to evaluate the effects of prenatal exposure to POP and organophosphate pesticides on fetal markers of glucose metabolism in a sample of newborns from the Pelagie mother–child cohort in Brittany (France). Methods Dialkylphosphate (DAP) metabolites of organophosphate pesticides were measured in maternal urine collected at the beginning of pregnancy. Cord blood was assayed for polychlorinated biphenyl congener 153 (PCB153), p,p′-dichlorodiphenyl dichloroethene (DDE) and other POP. Insulin and adiponectin were determined in cord blood serum (n=268). Results A decrease in adiponectin and insulin levels was observed with increasing levels of DDE, but only in girls and not boys. Adiponectin levels were not related to the concentrations of other POP or DAP metabolites. Decreasing insulin levels were observed with increasing PCB153 concentrations. Insulin levels increased with DAP urinary levels. Additional adjustment for BMI z-score at birth modified some of these relations. Conclusions Our observations bring support for a potential role of organophosphate pesticides and POP in alterations to glucose metabolism observable at birth
ISSN: 0013-9351

hal-01259218
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01259218
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01259218/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01259218/file/Prenatal%20exposure%20to%20persistent%20organic%20pollutants%20and%20organophosphate%20pesticides%2C%20and%20markers%20of%20glucose%20metabolism%20at%20birth.pdf
DOI : 10.1016/j.envres.2016.01.005

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