Résumé : Hierba anual de hasta 2 m de altura. Tallo áspero o rugoso. Hojas anchamente ovadas o suborbiculares de 3 a 5 lóbulos, con la base más o menos cordada, de 8 a 18 cm de largo y dentadas. Cabezuelas masculinas en el ápice de las ramas y en las axilas de las hojas; cabezuelas femeninas una o pocas en la base de las inflorescencias, con brácteas ganchudas. Fruto capsular, ovoide y espinoso; espinas rectas y ganchudas en el ápice.
Herbe annuelle pouvant atteindre 2 m de haut. Tige âpre ou rugueuse. Feuilles largement ovées ou suborbiculaires de 3 à 5 lobes, à base plus ou moins cordée, de 8 à 18 cm de long, dentées. Capitules mâles à la pointe des branches et à l’axe des feuilles; capitules femelles au nombre de 1 (ou un peu plus) à la base des inflorescences, avec bractées en forme de crochets. Fruit à capsule, ovoïde et épineux; épines droites et crochues à la pointe.
Annual monoecious herb 70 cm high. Leaves alternate, 7-12 cm long including petiole, base cordate or reniform, apex acute, 3-5 lobed and dentate, blades, scabrous, with appressed golden glandular hairs, triangular- orbicular 7-12 x 6-12 cm;  inflorescence racemose; male heads globose, numerous florets, female head burrlike with hooked bracts, 2 flowers; Achene, 0.9-1.5cm linear, compressed, beaked, smooth.
Cosmopolita.
Cosmopolite.
Cosmopolitan.

http://www.tramil.net/fototeca/plant361

Résumé : Arbol de hasta 18 m de alto. Hojas pecioladas, subcoriáceas, oblongo elípticas a lanceoladas, agudamente acuminadas, pinnado nervadas de hasta 13 cm de longitud. Inflorescencias estaminadas de 3 a 20 flores; las pistiladas usualmente de una sola flor; flores pequeñas, amarillo cremosas. Fruto piriforme o subgloboso (nuez) de hasta 5 cm, colgante, rojizo o amarillento, con dos valvas; semilla con arilo escarlata.
Arbre pouvant atteindre 18 m de haut. Feuilles pétiolées, presque coriaces, oblongo-elliptiques à lancéolées, terminées en pointe très fine, pennatinnervées pouvant atteindre 13 cm de long. Inflorescences staminées de 3 à 20 fleurs; celles qui sont pourvues d’un pistil ont habituellement une seule fleur; fleurs petites, jaunes-crèmes. Fruit piriforme ou presque arrondi pouvant atteindre 5 cm, tombant, rougeâtre ou jaunâtre, bivalve; graine avec arille écarlate.
Tree dioecious 6-18 m high with a dense crown and aromatic wood.  Leaves simple, alternate, oblong-elliptic, acutely acuminate, pinnately veined, dark green shiny above, paler beneath, 5-15 cm x 2-7 cm; male inflorescences usually 1-10 flowered cyme, fragrant, pale yellow, female inflorescences a 1-3 flowered cyme, but usually 1-flowered, pale yellow; fruit a fleshy, smooth, yellow, sub-globose, drupe, 3-6 cm long with a circumferential, longitudinal ridge; seed brown, ovoid 1.5-4.5cm long covered with a lacinate, red aril.
Nativa de Asia tropical, cultivada en los trópicos del resto del mundo.
Originaire d’;Asie tropicale, cultivée dans les tropiques du reste du monde.
Native to tropical Asia, cultivated in tropical regions around the world.

http://www.tramil.net/fototeca/plant239

Éditeur(s) : Ecole Nationale Vétérinaire de Nantes
Résumé : Aquaculture of penaeid shrimps holds a major place in productions of animals. New Caledonia takes part to these productions by developing the breeding of Pacific blue shrimp Litopenaeus stylirostris. Nowadays, penaeid larviculture can’t be undertaken unless antibiotics are used. Experiments in the Caledonian Aquacultural Laboratory (LAC IFREMER Saint-Vincent) put across to the development of two antibiotic prophylaxis plans for substitution of erythromycine, one plan with oxytetracycline (hydrochloride), the other plan with trimethoprime-sulfadiazine association. After an antimicrobial agent susceptibility testing of bacteria and an acute toxicity study, efficacity assays are the biological validation of these projects of protocols
L'aquaculture de la crevette Pénéide occupe une position majeure au sein des productions animales. La Nouvelle-Calédonie y participe activement grâce au développement de l'élevage de la crevette bleue du Pacifique Litopenaeus stylirostris. En l’état actuel de nos connaissances, l’élevage larvaire de crevettes ne peut être mené sans l’utilisation d’antibiotique Les expériences menées au Laboratoire Aquacole Calédonien (LAC IFREMER Saint-Vincent) ont conduit à la mise au point de deux plans d’antibioprévention de substitution à l’érythromycine, l’un employant l’oxytétracycline (chlorhydrate), l’autre utilisant l’association triméthoprime - sulfadiazine. Après une étude de la sensibilité des flores bactériennes hétérotrophe totale et Vibrionacée aux antibiotiques et une étude d’innocuité sur les larves de crevettes, les essais d’efficacité constituent la validation biologique des projets de protocoles.

Droits : 2003 The author / Ecole Nationale Vétérinaire de Nantes / ONIRIS / IFREMER
http://archimer.ifremer.fr/doc/00072/18312/15877.pdf
http://archimer.ifremer.fr/doc/00072/18312/

Éditeur(s) : HAL CCSD Ferrata Storti Foundation
Résumé : International audience
BACKGROUND: Little is known about the effects of blood rheology on the occurrence of acute chest syndrome and painful vaso-occlusive crises in children with sickle cell anemia and hemoglobin SC disease. DESIGN AND METHODS: To address this issue, steady-state hemorheological profiles (blood viscosity, red blood cell deformability, aggregation properties) and hematologic parameters were assessed in 44 children with sickle cell anemia and 49 children with hemoglobin SC disease (8-16 years old) followed since birth. Clinical charts were retrospectively reviewed to determine prior acute chest syndrome or vaso-occlusive episodes, and rates of these complications were calculated. RESULTS: Multivariate analysis revealed that: 1) a higher steady-state blood viscosity was associated with a higher rate of vaso-occlusive crises in children with sickle cell anemia, but not in children with hemoglobin SC disease; 2) a higher steady-state red blood cell disaggregation threshold was associated with previous history of acute chest syndrome in children with hemoglobin SC disease and boys with sickle cell anemia. CONCLUSIONS: Our results indicate for the first time that the red blood cell aggregation properties may play a role in the pathophysiology of acute chest syndrome in children with hemoglobin SC disease and boys with sickle cell anemia. In addition, whereas greater blood viscosity is associated with a higher rate of vaso-occlusive crises in children with sickle cell anemia, no association was found in children with hemoglobin SC disease, underscoring differences in the etiology of vaso-occlusive crises between sickle cell anemia and hemoglobin SC disease.
ISSN: 0390-6078

inserm-00849038
http://www.hal.inserm.fr/inserm-00849038
http://www.hal.inserm.fr/inserm-00849038/document
http://www.hal.inserm.fr/inserm-00849038/file/inserm-00849038.pdf
DOI : 10.3324/haematol.2012.066670

Éditeur(s) : ISTPM
Résumé : The effect of the 2 pesticides most frequently used against mosquitoes was tested on a number of marine organisms. Growth inhibition was tested using Phaeodactylum tricornutum and Gyrosigma spencer (algae). To 0.5 ml of culture inoculum containing similar to 100000 cells in exponential growth phase, 9.5 ml of insecticide in varying concentrations were added and the growth was recorded every 48 hour; LG sub(50) was determined. Muscular activity and filtration rate of Crassostrea angulata were tested. The acute toxicity was tested using 4 species of gastropods, 2 lamellibranchs, 5 crustaceans, 1 coelenterate and 3 fishes; the species used were: Gibbula umbilicalis, Purpura lapillus, Littorina littorea, Patella vulgata, Mytilus edulis, Cardium edule, Artemia salina, Clinabarius misanthropus, Carcinus maenas, Crangon crangon, Palaemonetes varians, Actinia equina, Gasterosteus aculeatus, Pomatoschistus minutus and Anguilla anguilla. The LD sub(50) was determined for each concentration at intervals of 48 hour and 96 hour. It was noted that Abate was distinctly less toxic than Fenitrothion and that the crustaceans were extremely sensitive to Fenitrothion; a marginal security was found to exist in the oysters between the doses used in practice and those used in the test.
Revue des Travaux de l'Institut des Pêches Maritimes (0035-2276) (ISTPM), 1973-03 , Vol. 37 , N. 1 , P. 137-144

Droits : Ifremer
http://archimer.ifremer.fr/doc/1973/publication-2229.pdf
http://archimer.ifremer.fr/doc/00000/2229/

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
BACKGROUND: Evidence of human sexual transmission during Zika virus emergence is a matter of concern, particularly in procreation, but to date, kinetics of seminal shedding and the effects of infection on human reproductive function have not been described. To investigate the effects of Zika virus infection on semen and clearance of Zika virus from semen and body fluids, we aimed to study a cohort of Zika virus-infected men. METHODS: This prospective observational study recruited men presenting with acute Zika virus infection at Pointe-à-Pitre University Hospital in Guadeloupe, French Caribbean, where a Zika virus outbreak occurred between April and November, 2016. Blood, urine, and semen were collected at days 7, 11, 20, 30, 60, 90, and 120 after symptom onset, and semen characteristics, such as total sperm count, sperm motility, vitality, and morphology, and reproductive hormone concentrations, such as testosterone, inhibin, follicle-stimulating hormone, and luteinising hormone, were assessed. At days 7, 11, and 20, semen was processed to isolate motile spermatozoa. Zika virus RNA was detected by RT-PCR using whole blood, serum, urine, seminal plasma, semen cells, and motile spermatozoa fractions. Zika virus was isolated from different sperm fractions on Vero E6 cultures. FINDINGS: 15 male volunteers (mean age 35 years [SD 5; range 25-44) with acute Zika virus infection and positive Zika virus RNA detection in blood or urine were enrolled. Total sperm count was decreased from median 119 × 10(6) spermatozoa (IQR 22-234) at day 7 to 45·2 × 10(6) (16·5-89·6) at day 30 and 70 × 10(6) (28·5-81·4) at day 60, respectively, after Zika virus infection. Inhibin values increased from 93·5 pg/mL (IQR 55-162) at day 7 to 150 pg/mL (78-209) at day 120 when total sperm count recovered. In motile spermatozoa obtained after density gradient separation, Zika virus RNA was found in three of 14 patients at day 7, four of 15 at day 11, and four of 15 at day 20, and replication-competent virus was found in the tested patient. Seminal shedding kinetics seemed heterogeneous among patients. Whole blood was the fluid most frequently positive for Zika virus RNA (62 of 92 samples) and three patients remained positive at day 120. INTERPRETATION: Semen alterations early after acute Zika virus infection might affect fertility and could be explained by virus effects on the testis and epididymis. Frequency of shedding and high viral load in semen, together with the presence of replicative virus in a motile spermatozoa fraction, can lead to Zika virus transmission during sexual contact and assisted reproduction procedures. Whole blood seems to be the best specimen for Zika virus RNA detection, diagnosis, and follow-up. FUNDING: Agence de la Biomédecine/Agence Régionale de Santé de la Guadeloupe/Inserm-REACTing.
ISSN: 0140-6736

hal-01647078
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01647078
DOI : 10.1016/S1473-3099(17)30444-9
PUBMED : 28838639

Résumé : Arbusto de 1 a 4 m de alto. Hojas alternas, aovadas, agudas a acuminadas en el ápice, aserradas. Bractéolas 5 a 7, lineales. Cáliz campanulado; corola blanca, roja purpúrea, amarilla o anaranjada, de tamaño variable, muy vistosa; tubo estaminal más largo que los pétalos. Cápsula oblonga de casi 3 cm de diámetro.
Arbuste de 1 à 4 m de haut. Feuilles alternes, ovées, pointues à acuminées à l’extrémité, denticulées. 5 à 7 petites bractées linéaires. Calice en forme de cloche; corolle blanche, rouge pourpre, jaune ou orangée, de taille variable, aux couleurs éclatantes; filet staminal plus long que les pétales. Capsule oblongue de presque 3 cm de diamètre.
Shrub, 1-4 m high.  Leaves 15cm x 10cm, spiraling around the stem,ovate, acute to acuminate at the tip, marginsserrate; flowers solitary, born on long stalks, in the axils of the upper leaves, epicalyx of 5-7 bractioles about 1 cm long, calyx cup-shaped 2.5cm long, corolla short-lived, showy, mainly red, but other varieties range frompurplish-red, yellow or orangeto white,variable in size,from 6-10cm,staminal tube longer than petals; capsules, rarely produced are oblong ca. 3 cm long, seeds globose ca.3 mm in diameter.
Originaria de Asia y cultivada en las zonas tropicales de todo el mundo.
Originaire d’Asie et cultivée dans les zones tropicales du monde entier.
Native to Asia and cultivated in tropical regions around the world.

http://www.tramil.net/fototeca/plant188

Éditeur(s) : HAL CCSD
Résumé : Background Acute splenic sequestration is one of the major clinical forms of sickle cell disease. This potentially life-threatening complication is defined by a rapid sequestration of sickle red blood cells in the spleen. Approximately 30% of young patients will develop this complication and 49% of them will have recurrences. Methods The decision tree method is a statistical method that can act as a medical decision tool in the case of a complex biological problem. The decision tree method is used here to determine the variables involved in the severity and recurrence of acute splenic sequestration crises. Results A prior decision tree shows that platelet level, variation in spleen size, patient age and hygrometry also called relative humidity define acute splenic sequestration severity. A second one shows that spleen size variation, atmospheric pressure and patient age define recurrence. Conclusions For the first time, biological and environmental parameters are combined to discover some interesting rules which can lead to more accurate evaluations of acute splenic sequestration severity and recurrence. Thus, this method provides a sharp diagnostic tool which could improve medical treatment for better patient care.
https://hal.archives-ouvertes.fr/hal-00201460

hal-00201460
https://hal.archives-ouvertes.fr/hal-00201460
https://hal.archives-ouvertes.fr/hal-00201460v2/document
https://hal.archives-ouvertes.fr/hal-00201460/file/DT_Marianne_v2.pdf

Résumé : Hierba perenne muy aromática, glabra, erecta de 30 a 95 cm; muy resinosa al secarse. Hojas opuestas, sésiles, lineares u oblongo-lanceoladas, de 5 a 10 mm de largo, obtusas o agudas en el ápice, finamente dentadas. Flores amarillas en pequeñas cabezuelas terminales, de 9 a 10 mm de diámetro, involucro cilíndrico, brácteas comúnmente 3. Aquenios de 6 a 7 mm, estriados.
Herbe pérenne très aromatique, glabre, dressée, de 30 à 95 cm, très résineuse une fois séchée. Feuilles opposées, sessiles, linéaires ou oblongues-lancéolées, de 5 à 10 mm de long, obtuses ou aiguës à la pointe, finement dentées. Fleurs jaunes disposées en petits capitules terminaux, de 9 à 10 mm de diamètre; involucre cylindrique, bractées habituellement au nombre de 3. Akènes de 6 à 7 mm, striés.
Annualherb, highly scented, glabrous, erect, 30-95 cm; very resinous when dried.  Leaves opposite, sessile, linear or oblong-lanceolate, 5-10 mm long, obtuse or acute at the apex, finely dentate.  Flowers yellow, in small terminal heads, 9-10 mm in diameter, involucre cylindrical, bracts usually 3 in number.  Achenes 6-7 mm long, striate.
Nativa de México, Guatemala, Salvador y Honduras.
Originaire du Mexique, du Guatemala, du Salvador et du Honduras.
Native to Mexico, Guatemala, Salvador and Honduras.

http://www.tramil.net/fototeca/plant343

Éditeur(s) : HAL CCSD Endocrine Society
Résumé : International audience
Transcriptional regulation by the estrogen receptor-alpha(ER) has been investigated mainly in breast cancer cell lines, but estrogens such as 17 beta-estradiol (E2) exert numerous extrareproductive effects, particularly in the liver, where E2 exhibits both protective metabolic and deleterious thrombotic actions. To analyze the direct and early transcriptional effects of estrogens in the liver, we determined the E2-sensitive transcriptome and ER cistrome in mice after acute administration of E2 or placebo. These analyses revealed the early induction of genes involved in lipid metabolism, which fits with the crucial role of ER in the prevention of liver steatosis. Characterization of the chromatin state of ER binding sites (BSs) in mice expressing or not ER demonstrated that ER is not required per se for the establishment and/or maintenance of chromatin modifications at the majority of its BSs. This is presumably a consequence of a strong overlap between ER and hepatocyte nuclear factor 4 alpha BSs. In contrast, 40% of the BSs of the pioneer factor forkhead box protein a (Foxa2) were dependent upon ER expression, and ER expression also affected the distribution of nucleosomes harboring dimethylated lysine 4 of Histone H3 around Foxa2 BSs. We finally show that, in addition to a network of liver-specific transcription factors including CCAAT/enhancer-binding protein and hepatocyte nuclear factor 4 alpha, ER might be required for proper Foxa2 function in this tissue.
ISSN: 0888-8809

hal-01357623
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01357623
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01357623/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01357623/file/Changes%20in%20gene%20expression%201%20and%20Estrogen%20Receptor_accepted.pdf
DOI : 10.1210/me.2015-1311

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : International audience
The Société de pneumologie de langue française defines acute exacerbation of chronic obstructive pulmonary disease (AE COPD) as an increase in daily respiratory symptoms, basically duration ≥ 48h or need for treatment adjustment. Etiology of EA COPD are mainly infectious, viral (rhinovirus, influenzae or parainfluenzae virus, coronavirus, adenovirus and respiratory syncytial virus) or bacterial (Haemophilus influenzae, Streptococcus pneumoniae, or Moraxella catarrhalis). Pollutant exposure can also lead to AE COPD, such as NO2, SO2, ozone or particulates (PM10 and PM2.5). In 30% the etiology remains unknown. Differential diagnoses of AE COPD include infectious pneumonia, pneumothorax, acute heart failure and pulmonary embolism. Presences of signs of severity impose hospitalization: signs of respiratory distress, shock, acute confusion but also fragile patients, insufficient home support or absence of response to initial treatment. AE COPD treatments consist on increase in bronchodilators, chest physiotherapy, and antibiotics if sputum is frankly purulent. Systemic corticosteroids should not be systematic.Recommended dose is 0.5 mg/kg on short course (7 days). During hospitalization, oxygen supplementation and thromboprophylaxis could be prescribed. The main interest in noninvasive ventilation is persistent hypercapnia despite optimal medical management. During ambulatory management or hospitalization, clinical assessment at 48-72h is mandatory. L’exacerbation aiguë de bronchopneumopathie chronique obstructive (EA BPCO) représente un événement important dans l’histoire naturelle de la BPCO, notamment en cas d’hospitalisation. Les EA BPCO interviennent dans la gravité et l’évolution de la BPCO ; et leur prévention est un des objectifs principal des traitements de fond.
La Société de pneumologie de langue française définie l’exacerbation aiguë de bronchopneumopathie chronique obstructive (EA BPCO) comme une majoration des symptômes respiratoires au-delà des variations quotidiennes, en pratique, d’une durée ≥ 48h ou justifiant une modification thérapeutique. L’étiologie de ces EA BPCO est principalement infectieuse, virale (rhinovirus, virus influenzae et parainfluenzae, coronavirus, adénovirus et virus respiratoire syncytial) ou bactérienne (principalement Haemophilus influenzae, Streptococcus pneumoniae et Moraxella catarrhalis). Elles peuvent également résulter de l’exposition à certains polluants comme le NO2, le SO2, l’ozone et la pollution particulaire (PM10 et PM2,5). L’étiologie reste indéterminée dans près de 30 % des cas. Les diagnostics différentiels des EA BPCO incluent les pneumopathies infectieuses, les pneumothorax, les poussées d’insuffisance cardiaque et les embolies pulmonaires. La présence de signes de gravité conditionnent l’hospitalisation : signes d’insuffisance respiratoire aiguë, de choc ou de défaillance neurologique, mais aussi en cas de patient fragile, d’absence de soutien familial à domicile ou d’absence de réponse au traitement initial. Le traitement d’une EA BPCO consiste en une majoration des bronchodilatateurs, une kinésithérapie respiratoire, une antibiothérapie en cas d’expectoration franchement purulente.La prescription de corticoïdes systémiques ne doit pas être systématique. La dose recommandée est de 0,5 mg/kg sur une courte période (7 jours). Lors d’une hospitalisation, une oxygénothérapie et une thromboprophylaxie peuvent être prescrite. La ventilation noninvasiveest principalement indiquée en cas de persistance d’une hypercapnie malgré un traitement médical optimal. Que le patient soit pris en charge en ambulatoire ou en hospitalisation, une réévaluation clinique à 48-72h est indispensable.
ISSN: 0755-4982

hal-01117949
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01117949
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01117949/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01117949/file/Prise%20en%20charge%20des%20exacerbations_accepted.pdf
DOI : 10.1016/j.jeurea.2015.02.002

Éditeur(s) : HAL CCSD Ferrata Storti Foundation
Résumé : International audience
The aim of the study was to determine the factors associated with resting and exercise-induced hemoglobin oxygen desaturation. The well-established six-minute walk test was conducted in 107 sickle cell children (50 with sickle hemoglobin C disease and 57 with sickle cell anemia) at steady state. Hemoglobin oxygen saturation was measured before and immediately after the six-minute walk test. Blood samples were obtained on the same day to measure hematologic and hemorheological parameters. Exercise-induced hemoglobin oxygen desaturation was defined as a drop in hemoglobin oxygen saturation of 3% or more at the end of the six-minute walk test compared to resting levels. No children with sickle hemoglobin C disease, but approximately 50% of children with sickle cell anemia showed mild or moderate oxygen desaturation at rest, which was independently associated with the percentage of reticulocytes. Exercise-induced hemoglobin oxygen desaturation was observed in 18% of children with sickle hemoglobin C disease and 34% of children with sickle cell anemia, and was independently associated with the six-minute walk test, acute chest syndrome rate and the strength of red blood cell aggregates in children with sickle cell anemia. No association was found in children with sickle hemoglobin C disease between exercise-induced hemoglobin oxygen desaturation and the measured parameters. Hemoglobin oxygen desaturation at rest was common in children with sickle cell anemia but not in children with sickle hemoglobin C disease, and was mainly associated with greater hemolysis. Physiological strain during exercise and red blood cell aggregation properties may predict the occurrence of exercise-induced hemoglobin oxygen desaturation in children with sickle cell anemia.
ISSN: 0390-6078

inserm-00838989
http://www.hal.inserm.fr/inserm-00838989
http://www.hal.inserm.fr/inserm-00838989/document
http://www.hal.inserm.fr/inserm-00838989/file/Waltz_et_al._Ferrata_Storti_Foundation.pdf
DOI : 10.3324/haematol.2013.083576

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
The IL-33/ST2 axis is known to be involved in liver pathologies. Although, the IL-33 levels increased in sera of viral hepatitis patients in human, the cellular sources of IL-33 in viral hepatitis remained obscure. Therefore, we aimed to investigate the expression of IL-33 in murine fulminant hepatitis induced by a Toll like receptor (TLR3) viral mimetic, poly(I:C) or by pathogenic mouse hepatitis virus (L2-MHV3). The administration of poly(I:C) plus D-galactosamine (D-GalN) in mice led to acute liver injury associated with the induction of IL-33 expression in liver sinusoidal endothelial cells (LSEC) and vascular endothelial cells (VEC), while the administration of poly(I:C) alone led to hepatocyte specific IL-33 expression in addition to vascular IL-33 expression. The hepatocyte-specific IL-33 expression was down-regulated in NK-depleted poly(I:C) treated mice suggesting a partial regulation of IL-33 by NK cells. The CD1d KO (NKT deficient) mice showed hepatoprotection against poly(I:C)-induced hepatitis in association with increased number of IL-33 expressing hepatocytes in CD1d KO mice than WT controls. These results suggest that hepatocyte-specific IL-33 expression in poly(I:C) induced liver injury was partially dependent of NK cells and with limited role of NKT cells. In parallel, the L2-MHV3 infection in mice induced fulminant hepatitis associated with up-regulated IL-33 expression as well as pro-inflammatory cytokine microenvironment in liver. The LSEC and VEC expressed inducible expression of IL-33 following L2-MHV3 infection but the hepatocyte-specific IL-33 expression was only evident between 24 to 32h of post infection. In conclusion, the alarmin cytokine IL-33 was over-expressed during fulminant hepatitis in mice with LSEC, VEC and hepatocytes as potential sources of IL-33.
ISSN: 1932-6203

hal-00874120
https://hal.archives-ouvertes.fr/hal-00874120
https://hal.archives-ouvertes.fr/hal-00874120/document
https://hal.archives-ouvertes.fr/hal-00874120/file/Pathogenic_Mouse_Hepatitis-accepted.pdf
DOI : 10.1371/journal.pone.0074278

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
Interleukin-33 (IL-33), a cytokine belonging to the IL-1 family, is crucially involved in inflammatory pathologies including liver injury and linked to various modes of cell death. However, a link between IL-33 and necroptosis or programmed necrosis in liver pathology remains elusive. We aimed to investigate the regulation of IL-33 during necroptosis-associated liver injury. The possible regulation of IL-33 during liver injury by receptor-interacting protein kinase 1 (RIPK1) and poly(ADP-ribose) polymerase 1 (PARP-1) was investigated in mice in vivo and in hepatic stellate cells in vitro. The liver immunohistopathology, flow cytometry, serum transaminase measurement, ELISA, and qPCR-based cytokine measurement were carried out. By using a chemical approach, we showed that pretreatment of mice with Necrostatin-1 (Nec-1) (inhibitor of RIPK1) and/or PJ34 (inhibitor of PARP-1) significantly protected mice against concanavalin A (ConA) liver injury (aspartate amino-transferase (AST)/alanine amino-transferase (ALT)) associated with down-regulated hepatocyte-specific IL-33 expression. In contrast, the expression level of most systemic cytokines (except for IL-6) or activation of liver immune cells was not altered by chemical inhibitors rather an increased infiltration of neutrophils in the liver. During polyinosine-polycytidylic acid (Poly(I:C))-induced acute hepatitis, liver injury and hepatocyte-specific IL-33 expression was also inhibited by PJ34 without any protective effect of PJ34 in CCl4-induced liver injury. Moreover, PJ34 down-regulated the protein expression of IL-33 in activated hepatic stellate cells by cocktail of cytokines or staurosporine in vitro. In conclusion, we evidenced that the Nec-1/PJ34 is a potent inhibitor of liver injury and Nec-1/PJ34 down-regulated hepatocyte-specific IL-33 expression in the liver in vivo or in hepatic stellate cells in vitro, suggesting IL-33 as a possible readout of necroptosis-involved liver pathologies. Necroptosis inhibitors can protect mice against liver injury induced by ConA or Poly(I:C). IL-33 expression in liver injury in vivo is inhibited by PJ34. IL-33 expression in hepatic stellate cells in vitro is inhibited by PJ34. Hepatocyte-specific IL-33 expression is down-regulated by Nec-1/PJ34 during hepatitis. IL-33 is a new marker of necroptosis-associated liver injuries.
ISSN: 0946-2716

hal-01134319
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01134319
DOI : 10.1007/s00109-015-1270-6
PUBMED : 25747661

Résumé : Arbolito de 6 a 8 m, ramas jóvenes hirsutas. Hojas corto-pecioladas u obovado-oblongas de 15 a 30 cm, abruptamente acuminadas, redondeadas u obtusas en la base. Inflorescencia pequeña, cauliflora; flores largamente pecioladas; cáliz rosado, de 6-7 mm; pétalos amarillos. Fruto glabro, ovoide-oblongo, gradualmente atenuado en el ápice, 10-sulcado, los surcos irregularmente rugosos-tuberculados; semillas ovoideas.
Petit arbre de 6 à 8 m, branches jeunes hirsutes. Feuilles à court pétiole ou ovées-oblongues de 15 à 30 cm, se terminant brusquement en pointe, base arrondie, ou obtuse. Inflorescence petite, caulinaire; fleurs à long pétiole; calice rosé, de 6-7 mm; pétales jaunes. Fruit glabre, ovoïde-oblongue, dont l’extrémité s’affine graduellement, avec 10 sillons irrégulièrement rugueux-tuberculés, pulpe blanche sucrée; graines ovoïdes.
Small tree, 6- 8 (-12-14) m high.  Leaf, alternate, simple, entire, sinuate, petiole 1-2 cm, blades obovate-elliptic to oblong elliptic, 16-40 x 4.5-13 cm, base rounded to obtuse, apex acute; inflorescence axillary, 1-many flowered, clustered cymes, cauliflorous; petals white 4-4.5 mm long; fruit a glabrous, ellipsoid, leathery berry, 10-20 x 8-10 cm wide, ripening green, yellow, red or purple; seeds brown, ovoid or elliptic, 2-4x1.2-2 cm long with a sweet surrounding pulp.
Nativa de Mesoamérica y Sudamérica, cultivada ampliamente en los trópicos.
Originaire d’;Amérique centrale et d’;Amérique du sud, abondamment cultivée sous les tropiques.
Native to Middle and South America, widely cultivated in tropical r

http://www.tramil.net/fototeca/plant347

Résumé : Hierba o arbusto densamente ramificado. Hojas con pecíolo delgado, solitarias o en pares, ovadas u ovado-lanceoladas, ápice acuminado. Dos flores o más en cada nudo, rara vez una; cáliz truncado o con lóbulos diminutos; corola blanco-verdosa o blanco amarillenta. Fruto rojo, de 1.5 a 3 cm de diámetro, elipsoide-lanceolado o lanceolado, con ápice agudo. Semillas cremosas a amarillentas. Especie muy elastica con una gran cantidad de cultivares que poseen una gran diversidad de forma en sus frutos.
Herbe ou arbuste à ramifications denses. Feuilles avec pétiole fin, solitaires ou par paires, ovalées ou ovalées-lancéolées, acuminées. Deux fleurs ou plus sur chaque noeud, rarement une; calice tronqué ou à très petits lobes; corolle blanche-verdâtre ou blanche-jaunâtre. Fruit rouge, de 1,5 à 3 cm de diamètre, ellipsoïde-lancéolé ou lancéolé, acuminé. Graines de couleur crème à jaunâtre. Espèce très élastique par une grande quantité de cultivars possédant une grande variété de formes de fruits.
Annual shrub densely branching.  Leaf with thin petiole, either single or in pairs, ovate to ovate-lanceolate, with acuminate tip; flowers solitary or two or moreper node, 5-petals, whitish-green or whitish-yellow; fruit 1.5- 3.5 cm in diameter, ellipsoid-lanceolate or lanceolate with acute tip, crinkled, red, green, yellow or orange; seeds cream or yellowish.
Originaria de América tropical. Cultivada en zonas tropicales y templadas.
Originaire d';Amérique tropicale. Cultivée dans les zones tropicales et tempérées.
Tropical America.  Cultivated in regions with tropical and moderate climates.

http://www.tramil.net/fototeca/plant90

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Hemorheological abnormalities have been well characterized in sickle cell disease (SCD) and seem to modulate the clinical severity [1]. For instance, increased blood viscosity raises the risk for frequent vaso-occlusive crisis (VOC) and increased red blood cell (RBC) aggregates robustness (i.e., RBC disaggregation threshold) enhances the risks for acute chest syndrome (ACS) [2]. Moreover, patients with the most rigid RBCs are characterized by high hemolytic rate, which increases the risks to develop leg ulcers or glomerulopathy [3]. However, except few studies supporting an effect of alpha-thalassemia and oxidative stress [1] on RBC rheological properties of SCD patients, very few experiments focused on the genetic and cellular factors modulating blood rheology in this disease.
ISSN: 1079-9796

hal-01263890
https://hal.archives-ouvertes.fr/hal-01263890
https://hal.archives-ouvertes.fr/hal-01263890/document
https://hal.archives-ouvertes.fr/hal-01263890/file/Ferdinand%20et%20al.%20eNOS%20and%20RBC%20rheology%20in%20SCD_BCMD.pdf
PUBMED : 26142331

Résumé : Herbácea anual o bianual de 20 a 80 cm de alto, tallos con indumento hirsuto-glanduloso. Hojas estrechamente sagitadas, linear-lanceoladas, ápice agudo o acuminado, margen generalmente revoluto, el haz verde densa o escasamente hirsuto-glanduloso, envés con indumento lanoso. Inflorescencia glomerular simple o corimbosa; corola amarilla en ocasiones con ápice café. Aquenios oblongos o estrechamente obovados, de color café.
Herbacée annuelle ou bisannuelle de 20 à 80 cm de haut, tiges avec revêtement hirsute-glanduleux. Feuilles étroitement sagittées, linéaires-lancéolées, pointe aiguë ou acuminée, bord généralement enroulé sur lui-même, dessus vert dense ou légèrement hirsute-glanduleux, dessous avec revêtement laineux. Inflorescence glomérulée simple ou corymbuleuse; corolle jaune parfois avec pointe couleur café. Akènes oblongs ou étroitement ovés, couleur café.
Annual or biannual herb, 20-80 cm high.  Stems with hirsute-glandulose.  Leaves, linear-lanceolate, apex acute or acuminate, margin usually revolute, veinsgreen, densely or scarcely hirsute-glandulose, underside with wooly surface.  Inflorescence head, simple or corymbose; corolla yellow, sometimes with coffee-colored apex.  Achenes oblong or tightly obovate, coffee-colored.
América tropical y subtropical.
Amérique tropicale et subtropicale.
Tropical and subtropical America.

http://www.tramil.net/fototeca/plant258

Résumé : Hierba anual, erguida, leñosa en la base, de hasta 3 o 4 m, no ramificada. Hojas orbiculares, de 10-30 cm, 5-7 lobadas; lóbulos lanceolados a aovados aserrados, agudos u obtusos. Cáliz de 2 cm, pétalos amarillos con manchas purpúreas en el centro, de 3-4 cm. Fruto capsular anguloso de hasta 20 cm, acuminada, viscosa.
Herbacée annuelle, ligneuse à la base, pouvant atteindre 3-4 mètres, sans ramifications. Feuilles orbiculaires, de 10 à 30 cm, 5-7 lobulées; lobules de lancéolés à ovoïdes dentelés, aigus ou obtus. Fleur à calice de 2 cm, pétales jaunes avec taches pourpres au centre, de 3-4 cm. Fruit capsulaire anguleux pouvant atteindre 20 cm, acuminé, visqueux.
Erect undershrub2-4 m high. Leaves orbicular and lobed 10-30 cm long; lanceolate to obovate, acute or obtuse; calyx 2 cm long, yellow corolla with a 3-4 cm purple area at the base; angular capsule (fruit), up to 20 cm long.
Originario del Viejo Mundo. Cultivada en las regiones tropicales y subtropicales.
Plante originaire de l';Ancien Monde; cultivée dans les régions tropicales et subtropicales.
Native to the Old World.  Cultivated in tropical and subtr

http://www.tramil.net/fototeca/plant1

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
Bronchoalveolar lavage (BAL) is a major diagnostic tool in lung diseases, including viral respiratory infections. We aimed to better define the situations where viral tests should be performed on BAL fluid (BALF). We retrospectively studied all cases where viral tests [immunofluorescence, immunocytochemistry, viral culture, and/or polymerase chain reaction (PCR)] were performed on BALF during a period of 1 year (2008) in our institution. We compared the characteristics of patients with virus-positive versus virus-negative BALF. Of the 636 BALF samples sent to the microbiology laboratory, 232 underwent viral tests. Of these, 70 (30 %) were positive and identified 85 viruses: herpes simplex virus (HSV)-1 (n = 27), cytomegalovirus (CMV, n = 23), Epstein-Barr virus (EBV, n = 18), human herpesvirus (HHV)-6 (n = 12), respiratory syncytial virus (RSV, n = 3), rhinovirus (n = 1), and adenovirus (n = 1). The variables associated with positive viral tests on univariate analysis were immunosuppression [human immunodeficiency virus (HIV), corticosteroids >10 mg/day for ≥3 weeks, or other immunosuppressive therapy], ground-glass attenuations on computed tomography (CT) scanning, late-onset ventilator-associated pneumonia (VAP), and durations of (i) hospital stay, (ii) intensive care unit (ICU) stay, and (iii) mechanical ventilation before BAL (p < 0.01 for each comparison). On multivariate analysis, only immunosuppression [odds ratio (OR) 6.4, 95 % confidence interval (CI) [2.8-14.3], p < 0.0001] and ground-glass attenuations (OR 3.7, 95 % CI [1.8-7.7], p = 0.0004) remained associated with virus-positive BAL. None of the viral tests performed on BALF for the initial assessment of diffuse infiltrative lung disease (n = 15) was positive. PCR improved the diagnostic yield of viral tests on BALF by 50 %. Testing for viruses on BALF should be mostly restricted to immunocompromised patients with acute respiratory diseases and/or patients with unexplained ground-glass attenuations on CT scanning.
ISSN: 0934-9723

hal-00873158
https://hal.archives-ouvertes.fr/hal-00873158
DOI : 10.1007/s10096-012-1791-7
PUBMED : 23238685