Éditeur(s) : HAL CCSD BMJ Publishing Group
Résumé : International audience
OBJECTIVE: To investigate the role of occupational exposure to chlorinated solvents in lung cancer aetiology. METHODS: ICARE (Investigation of occupational and environmental CAuses of REspiratory cancers) is a French, multicentre, population-based, case-control study. Information on the lifelong work history of 2926 cases and 3555 controls was collected using standardised questionnaires. Occupational exposures were assessed using job-exposure matrices for five chlorinated solvents. Solvents were studied separately and in combinations. ORs were computed using unconditional logistic regression models adjusted for classic risk factors, including a history of cigarette smoking and exposure to asbestos. Adjustment for socioeconomic status (SES) was also made. RESULTS: After adjustment for exposure to asbestos, we observed a positive, statistically significant association with lung cancer for men and women exposed to a combination of perchloroethylene (PCE), trichloroethylene and dichloromethane (DCM). Further adjustment for SES slightly decreased this association. In contrast, no statistically significant associations were found for other solvent combinations. CONCLUSIONS: These results suggest that exposure to PCE may constitute a risk factor for lung cancer, especially among women, who seem to have a higher prevalence of exposure than men.
ISSN: 1351-0711

hal-01063908
https://hal.archives-ouvertes.fr/hal-01063908
DOI : 10.1136/oemed-2014-102182
PUBMED : 25015929

Éditeur(s) : HAL CCSD MDPI
Résumé : International audience
Marine micro-and macroorganisms are well known to produce metabolites with high biotechnological potential. Nearly 40 years of systematic prospecting all around the New Caledonia archipelago and several successive research programs have uncovered new chemical leads from benthic and planktonic organisms. After species identification, biological and/or pharmaceutical analyses are performed on marine organisms to assess their bioactivities. A total of 3582 genera, 1107 families and 9372 species have been surveyed and more than 350 novel molecular structures have been identified. Along with their bioactivities that hold promise for therapeutic applications, most of these molecules are also potentially useful for cosmetics and food biotechnology. This review highlights the tremendous marine diversity in New Caledonia, and offers an outline of the vast possibilities for natural products, especially in the interest of pursuing collaborative fundamental research programs and developing local biotechnology programs.
EISSN: 1660-3397

Droits : http://creativecommons.org/licenses/by/
hal-01292225
http://hal.upmc.fr/hal-01292225
http://hal.upmc.fr/hal-01292225/document
http://hal.upmc.fr/hal-01292225/file/marinedrugs-14-00058.pdf
DOI : 10.3390/md14030058

Éditeur(s) : HAL CCSD Copernicus Publications on behalf of the European Geosciences Union
Résumé : International audience
During the GWADASEIS cruise (Lesser Antilles volcanic arc, February–March 2009) a very high resolution (VHR) seismic-reflection survey was performed in order to constrain Late Quaternary to Present faulting. The profiles we obtained evidence frequent " ponding " of reworked sediments in the deepest areas, similar to the deposition of Mediterranean " homogenites ". These bodies are acoustically transparent (few ms t.w.t. thick) and are often deposited on the hanging walls of dominantly normal faults, at the base of scarps. Their thickness appears sufficient to compensate (i.e. bury) co-seismic scarps between successive earthquakes, resulting in a flat and horizontal sea floor through time. In a selected area (offshore Montserrat and Nevis islands), piston coring (4 to 7 m long) was dedicated to a sedimento-logical analysis of the most recent of these particular layers. It corresponds to non-stratified homogenous calcareous silty sand (reworked calcareous plankton and minor volcanoclas-tics). This layer can be up to 2 m thick, and overlies fine-grained hemipelagites. The upper centimeters of the latter represent the normal RedOx water/sediment interface. 210 Pb and 137 Cs activities lack in the massive sands, while a normal profile of unsupported 210 Pb decrease is observed in the hemipelagite below, together with a 137 Cs peak corresponding to the Atmospheric Nuclear Experiments (1962). The RedOx level was thus capped by a recent instantaneous major sedimentary event considered as post-1970 AD; candidate seismic events to explain this sedimentary deposits are either the 16 March 1985 earthquake or the 8 October 1974 one (M w = 6.3 and M w = 7.4, respectively). This leads to consider that the syntectonic sedimentation in this area is not continuous but results from accumulation of thick homogen-ites deposited after the earthquakes (as observed in the following weeks after Haiti January 2010 event, McHugh et al., 2011). The existence of such deposits suggests that, in the area of study, vertical throw likely results from cu-mulated effects of separated earthquakes rather than from aseismic creep. Examination of VHR profiles shows that all major co-seismic offsets are recorded in the fault growth sequence and that co-seismic offsets can be precisely estimated. By using a sedimentation rate deduced from 210 Pb decrease curve (0.5 mm yr −1) and taking into account minor reworking events detected in cores, we show that the Redonda system may have been responsible for five > M 6 events during the last 34 000 yr. The approach presented in this work differs from fault activity analyses using displaced sets of isochronous surfaces and postulating co-seismic offsets. Combining VHR seismic imagery and coring we can decipher co-seismic vs. slow continuous displacement, and thus actually estimate the amplitude and the time distribution of major co-seismic offsets.
Natural Hazards and Earth System Science

insu-01585969
https://hal-insu.archives-ouvertes.fr/insu-01585969
https://hal-insu.archives-ouvertes.fr/insu-01585969/document
https://hal-insu.archives-ouvertes.fr/insu-01585969/file/nhess-12-1755-2012-beck.pdf
DOI : 10.5194/nhess-12-1755-2012

Éditeur(s) : HAL CCSD
Résumé : National audience
Mass balances are often used to calculate sediment fluxes in sedimentary basins and denudationrates in adjacent topographies on intermediate to long timescales (from a few tens ofthousand to a million years). In this study, we focus on simple Quaternary catchment–alluvial fansystems in the northern Tian Shan Range and its foreland basin to discuss some ideas about sedimentproduction, storage, release, and bypass in relatively short (100 km long) sediment routing systems.Based on a geometrical reconstruction of the fans, we estimated the volumes of sediments exportedout of the range and deposited in its alluvial piedmont during the Middle- Late Pleistocene andthe Holocene. This work shows that the two areas clearly present evidence of a temporary butsignificant storage of sediments during the Pleistocene. These sediments were then excavated anddelivered farther into the foreland basin during the Holocene. The difference between the volumesof materials released from the range and piedmont areas and the volume stored in thecontemporaneous fans downstream indicates that the latter did not trap the whole sediment loadtransported by the rivers. The alluvial fans were bypassed by 27 to 78% of this load toward thedownstream alluvial plain. It implies a major volumetric partitioning of the deposits between thefans and the alluvial plain, with a sedimentation rate about twenty times higher in the fans thanin the plain. However, this volumetric partitioning might only occur during periods with a veryspecific hydrological regime such as the Holocene deglaciation. Eventually, the peculiar sedimentstorage and release pattern within the range and piedmont areas during the Pleistocene and Holocenecomplicates the calculation of mean paleodenudation rates using either sediment budgets or in situproduced cosmogenic nuclides.
Association des Sédimentologistes Français. 15ème congrès français de sédimentologie
Chambéry, France

hal-01252100
https://hal.archives-ouvertes.fr/hal-01252100

Éditeur(s) : HAL CCSD
Résumé : International audience
Mass balances are often used to calculate sediment fluxes in sedimentary basins and denudationrates in adjacent topographies on intermediate to long timescales (from a few tens ofthousand to a million years). In this study, we focus on simple Quaternary catchment–alluvialfan systems in the northern Tian Shan Range and its foreland basin to discuss some ideasabout sediment production, storage, release, and bypass in relatively short (100 km long) sedimentrouting systems. Based on a geometrical reconstruction of the fans, we estimated thevolumes of sediments exported out of the range and deposited in its alluvial piedmont duringthe Middle-Late Pleistocene and the Holocene. This work shows that the two areas clearlypresent evidence of a temporary but significant storage of sediments during the Pleistocene.These sediments were then excavated and delivered farther into the foreland basin during theHolocene. The difference between the volumes of materials released from the range and piedmontareas and the volume stored in the contemporaneous fans downstream indicates thatthe latter did not trap the whole sediment load transported by the rivers. The alluvial fans werebypassed by 27 to 78% of this load toward the downstream alluvial plain. It implies a majorvolumetric partitioning of the deposits between the fans and the alluvial plain, with a sedimentationrate about twenty times higher in the fans than in the plain. However, this volumetricpartitioning might only occur during periods with a very specific hydrological regime suchas the Holocene deglaciation. Eventually, the peculiar sediment storage and release patternwithin the range and piedmont areas during the Pleistocene and Holocene complicates thecalculation of mean paleodenudation rates using either sediment budgets or in situ producedcosmogenic nuclides.
Source to Sink: a long term perspective of sediment budgets and sources characterization, Abstracts
Rennes, France

insu-01406440
https://hal-insu.archives-ouvertes.fr/insu-01406440

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
A new method to grow large single crystals with stoichiometry close to 1:1:2 of CuInSe2, an important member of the I-III-VI2 family of chalcopyrite semiconductors for optoelectronic device applications, is described. This is called the horizontal varying gradient zone freeze technique and consists of the selenization in the liquid phase of stoichiometric Cu and In and later solidification under programmed varying gradient in a fully automated multiple zone horizontal furnace. All ingots obtained with Se pressure between 15 and 1760 mm of Hg were single phase having chalcopyrite structure and p-type conductivity. X-ray, DTA, optical and electrical characterizations of the samples taken from different parts of the ingots were made. From energy dispersive spectroscopy it is found that the samples of the ingot obtained with Se pressure at 836 mm of Hg were much closer to the ideal stoichiometry 1:1:2.
ISSN: 0022-0248

hal-00808624
https://hal.univ-antilles.fr/hal-00808624
DOI : 10.1016/0022-0248(95)00346-0

Éditeur(s) : HAL CCSD American Geophysical Union (AGU)
Résumé : International audience
The Tian Shan Mountains constitute central Asia's longest and highest mountain range. Understanding their Cenozoic uplift history thus bears on mountain building processes in general, and on how deformation has occurred under the influence of the India-Asia collision in particular. In order to help decipher the uplift history of the Tian Shan, we collected 970 samples for magnetostratigraphic analysis along a 4571-m-thick section at the Jingou River (Xinjiang Province, China). Stepwise alternating field and thermal demagnetization isolate a linear magnetization component that is interpreted as primary. From this component, a magnetostratigraphic column composed of 67 polarity chrons are correlated with the reference geomagnetic polarity timescale between ~1 Ma and ~23.6 Ma, with some uncertainty below ~21 Ma. This correlation places precise temporal control on the Neogene stratigraphy of the southern Junggar Basin and provides evidence for two significant stepwise increases in sediment accumulation rate at ~16–15 Ma and ~11–10 Ma. Rock magnetic parameters also undergo important changes at ~16–15 Ma and ~11–10 Ma that correlate with changes in sedimentary depositional environments. Together with previous work, we conclude that growth history of the modern Tian Shan Mountains includes two pulses of uplift and erosion at ~16–15 Ma and ~11–10 Ma. Middle to upper Tertiary rocks around the Tian Shan record very young (<~5 Ma) counterclockwise paleomagnetic rotations, on the order of 15° to 20°, which are interpreted as because of strain partitioning with a component of sinistral shear that localized rotations in the piedmont.
ISSN: 0278-7407

insu-00376345
https://hal-insu.archives-ouvertes.fr/insu-00376345
https://hal-insu.archives-ouvertes.fr/insu-00376345/document
https://hal-insu.archives-ouvertes.fr/insu-00376345/file/2007TC002137.pdf
DOI : 10.1029/2007TC002137

Éditeur(s) : HAL CCSD
Résumé : Spatial variability of ground motion may be explained by local soil conditions; it is the so-called "site effects". Site effects are responsible for increasing duration and important amplification of strong ground motion during earthquakes and must be considered as a key parameter in local seismic hazard assessment. French West Indies are prone to strong site effects because of a particular geology, characterized by soft soil deposits and strong alteration of volcanic deposits. In this framework, and considering that French West Indies are considered as a high seismicity level zone in the French building code, part of seismic hazard mitigation policy consists in technical studies to perform identification and mapping of zones characterized by homogeneous seismic response and quantification of associated ground motion. It is the aim of seismic microzonations. In this presentation, we will expose the methodology used on the scale of municipalities for mapping homogeneous seismic areas, based on a study of geological and geotechnical conditions and some geophysical testings. Then, a study of vulnerability of buildings allows to estimate the probability of damage on various sectors for a scenario of risk corresponding to the seismic microzonation.
19ème Conférence Géologique de la Caraïbe
Le Gosier, Guadeloupe, France

hal-00614300
https://hal-brgm.archives-ouvertes.fr/hal-00614300

Éditeur(s) : HAL CCSD Landes Bioscience
Résumé : International audience
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
Autophagy

hal-00735751
https://hal.archives-ouvertes.fr/hal-00735751
PUBMED : 22966490

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The Tarim and Junggar basins in central Asia are capped by a thick pile of conglomerates, called the Xiyu Formation, that are commonly linked to a change in climate and/or accelerated uplift near the Plio-Pleistocene boundary. In order to better understand their origin and significance, we carried out a combined structural and magnetostratigraphic study in the Quilitage syncline (southern Tianshan), where the base of the Xiyu conglomerates is observed at both sides of the syncline. A balanced cross-section shows that, even at a local-scale, the base of the Xiyu conglomerates cannot be regarded as a single continuous stratigraphic layer. On the southern flank of the Quilitage syncline, we collected 172 samples collected for magnetostratigraphic dating identify 17 polarity chrons that date the new section from 5.2 to ~ 1.7 Ma and constrain the base of the Xiyu conglomerate here at ~ 1.7 Ma. This is 4.2 Ma younger than the age of the Xiyu previously found on the northern limb of the same syncline. Together with other magnetostratigraphic studies carried out around the Tianshan, our study unambiguously demonstrates that the onset of deposition of the Xiyu conglomerates is diachronous, and that the conglomerates are systematically younger toward the basin. Consequently, the Xiyu Formation should not be considered as a chronostratigraphic marker related to any particular tectonic or climatic event, but is instead a prograding gravel wedge that has prograded over the underthrusting forelands. A synthesis of chronologic and structural results yields progradation rates over the last 10 Ma on the order of ~ 2.0 mm/yr and ~ 3.9 mm/yr south and north of the Tianshan Mountains respectively. These rates are comparable to the shortening rate across the Tianshan range, suggesting that underthrusting is the main factor governing the progradation rate of the Xiyu Formation.
ISSN: 0012-821X

insu-00414151
https://hal-insu.archives-ouvertes.fr/insu-00414151
https://hal-insu.archives-ouvertes.fr/insu-00414151/document
https://hal-insu.archives-ouvertes.fr/insu-00414151/file/Charreau-EPSL-2009.pdf
DOI : 10.1016/j.epsl.2009.07.035

Éditeur(s) : Paris : Royez libraire
Siècle(s) traité(s) : 18
Droits : Domaine public
Provenance : Archives départementales de Guadeloupe
Permalien : http://www.manioc.org/patrimon/ADG17089
ADG17089

Éditeur(s) : Paris : Brochot père
Siècle(s) traité(s) : 19
Droits : Domaine public
Provenance : Collectivité territoriale de Martinique. Bibliothèque Schoelcher
Permalien : http://www.manioc.org/patrimon/SCH13054
SCH13054