Éditeur(s) : Lunes Lunes ( Havana, Cuba )
Résumé : Editor: 1960-1961 G. Cabrera Infante
Some issues have thematic titles.

Droits : All rights reserved by holding and source institution.
6665413
http://ufdc.ufl.edu/AA00013450/00002

Éditeur(s) : Lunes Lunes ( Havana, Cuba )
Résumé : Editor: 1960-1961 G. Cabrera Infante
Some issues have thematic titles.

Droits : All rights reserved by holding and source institution.
6665413
http://ufdc.ufl.edu/AA00013450/00002

Éditeur(s) : Lunes Lunes ( Havana, Cuba )
Résumé : Editor: 1960-1961 G. Cabrera Infante
Some issues have thematic titles.

Droits : All rights reserved by holding and source institution.
6665413
http://ufdc.ufl.edu/AA00013450/00002

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
: Until recently, synonymous mutations (which do not change amino acids) have been much neglected. Some evidence suggests that this kind of mutations could affect mRNA secondary structure or stability, translation kinetics and protein structure. To explore deeper the role of synonymous mutations, we studied their consequence on the functional activity of the estrogen receptor alpha (ERα). The ERα is a ligand-inducible transcription factor that orchestrates pleiotropic cellular effects, at both genomic and non-genomic levels in response to estrogens. In this work we analyzed in transient transfection experiments, the activity of ERα carrying the synonymous mutation Ala87, a polymorphism involving about 5-10% of the population. In comparison to the wild type receptor, our results show that ERαA87 mutation reduces the transactivation efficiency of ERα on an ERE reporter gene while its expression level remains similar. This mutation enhances 4-OHT-induced transactivation of ERα on an AP1 reporter gene. Finally, the mutation affects the subcellular localization of ERα in a cell type specific manner. It enhances the cytoplasmic location of ERα without significant changes in non-genomic effects of E2. The functional alteration of the ERαA87 determined in this work highlights the relevance of synonymous mutations for biomedical and pharmacological points of view.
Journal of steroid biochemistry and molecular biology

inserm-01015532
http://www.hal.inserm.fr/inserm-01015532
DOI : 10.1016/j.jsbmb.2014.02.016
PUBMED : 24607813

Éditeur(s) : HAL CCSD Coastal Education and Research Foundation
Résumé : The sinking of the Prestige tanker (November, 2002) spilled over 64000 tons of heavy fuel oil. The Prestige oil spill (POS) affected approximately 1000 km of coast belonging to Portugal, France and Spain and more than 600 sandy beaches were polluted along the Atlantic coast of Spain. Since POS, yearly surveys of two oiled sandy beaches (Galicia, NW Spain) have provided evidences regarding the oil pollution behavior and the influence of beach morphodynamics on the dynamics of the contamination. The analysis of wave climate, the extracted suction cores and the detected oil from 2004 and 2009 fieldworks have allowed to promote a conceptual model of the influence of beach morphodynamics on the first steps of an oil spill and to establish the effects on the long-term oil pollution
ISSN: 0749-0208

hal-00783182
https://hal.archives-ouvertes.fr/hal-00783182

Éditeur(s) : Lunes Lunes ( Havana, Cuba )
Résumé : Editor: 1960-1961 G. Cabrera Infante
Some issues have thematic titles.

Droits : All rights reserved by holding and source institution.
6665413
http://ufdc.ufl.edu/AA00013450/00002

Éditeur(s) : Lunes Lunes ( Havana, Cuba )
Résumé : Editor: 1960-1961 G. Cabrera Infante
Some issues have thematic titles.

Droits : All rights reserved by holding and source institution.
6665413
http://ufdc.ufl.edu/AA00013450/00002

Éditeur(s) : Lunes Lunes ( Havana, Cuba )
Résumé : Editor: 1960-1961 G. Cabrera Infante
Some issues have thematic titles.

Droits : All rights reserved by holding and source institution.
6665413
http://ufdc.ufl.edu/AA00013450/00002

Éditeur(s) : Lunes Lunes ( Havana, Cuba )
Résumé : Editor: 1960-1961 G. Cabrera Infante
Some issues have thematic titles.

Droits : All rights reserved by holding and source institution.
6665413
http://ufdc.ufl.edu/AA00013450/00002

Résumé : (Funding) Funded in part by the Institute for Museum and Library Services (IMLS), Ephemeral Cities Project.
Tampa |z 1271000 |2 ceeus
Hillsborough County |z 12057 |2 ceeus
United States of America -- Florida -- Hillsborough County -- Tampa

Droits : All rights reserved. 2005.
C24-00325

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
BACKGROUND: An association between education and preterm delivery has been observed in populations across Europe, but differences in methodology limit comparability. We performed a direct cross-cohort comparison of educational disparities in preterm delivery based on individual-level birth cohort data. METHODS: The study included data from 12 European cohorts from Denmark, England, France, Lithuania, the Netherlands, Norway, Italy, Portugal, and Spain. The cohorts included between 2434 and 99 655 pregnancies. The association between maternal education and preterm delivery (22-36 completed weeks of gestation) was reported as risk ratios, risk differences, and slope indexes of inequality with 95% confidence intervals (CIs). RESULTS: Singleton preterm live delivery proportion varied between 3.7% and 7.5%. There were large variations between the cohorts in the distribution of education and maternal characteristics. Nevertheless, there were similar educational differences in risk of preterm delivery in 8 of the 12 cohorts with slope index of inequality varying between 2.2 [95% CI 1.1, 3.3] and 4.0 [95% CI 1.4, 6.6] excess preterm deliveries per 100 singleton deliveries among the educationally most disadvantaged, and risk ratio between the lowest and highest education category varying from 1.4 [95% CI 1.1, 1.8] to 1.9 [95% CI 1.2, 3.1]. No associations were found in the last four cohorts. CONCLUSIONS: Educational disparities in preterm delivery were found all over Europe. Despite differences in the distributions of education and preterm delivery, the results were remarkably similar across the cohorts. For those few cohorts that did not follow the pattern, study and country characteristics did not explain the differences.
ISSN: 0269-5022

hal-01146842
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01146842
DOI : 10.1111/ppe.12185
PUBMED : 25808200

Éditeur(s) : Lunes Lunes ( Havana, Cuba )
Résumé : Editor: 1960-1961 G. Cabrera Infante
Some issues have thematic titles.

Droits : All rights reserved by holding and source institution.
6665413
http://ufdc.ufl.edu/AA00013450/00002

Éditeur(s) : García Monge y Cía. García Monge y Cía. ( San José Costa Rica )
Résumé : (Statement of Responsibility) Ricardo Fernández Guardia.

001088454
22469690
AFH3831

Éditeur(s) : Lunes Lunes ( Havana, Cuba )
Résumé : Editor: 1960-1961 G. Cabrera Infante
Some issues have thematic titles.

Droits : All rights reserved by holding and source institution.
6665413
http://ufdc.ufl.edu/AA00013450/00002

Résumé : (Funding) Funded in part by the Institute for Museum and Library Services (IMLS), Ephemeral Cities Project.
Tampa |z 1271000 |2 ceeus
Hillsborough County |z 12057 |2 ceeus
United States of America -- Florida -- Hillsborough County -- Tampa

Droits : All rights reserved. 2005.
C24-00232

Éditeur(s) : Lunes Lunes ( Havana, Cuba )
Résumé : Editor: 1960-1961 G. Cabrera Infante
Some issues have thematic titles.

Droits : All rights reserved by holding and source institution.
6665413
http://ufdc.ufl.edu/AA00013450/00002

Éditeur(s) : Lunes Lunes ( Havana, Cuba )
Résumé : Editor: 1960-1961 G. Cabrera Infante
Some issues have thematic titles.

Droits : All rights reserved by holding and source institution.
6665413
http://ufdc.ufl.edu/AA00013450/00002

Éditeur(s) : Lunes Lunes ( Havana, Cuba )
Résumé : Editor: 1960-1961 G. Cabrera Infante
Some issues have thematic titles.

Droits : All rights reserved by holding and source institution.
6665413
http://ufdc.ufl.edu/AA00013450/00002

Éditeur(s) : Inter-research
Résumé : Chemical tracers (e. g. stable isotopes or trace metals) are increasingly used to study trophic ecology and feeding habits of marine organisms and various factors can affect their values. The aim of the present study was to provide information on ontogenic effects on stable carbon and nitrogen values (delta C-13 and delta N-15) and on cadmium (Cd) and mercury (Hg) concentrations in 5 cephalopod species from the Bay of Biscay (North-East Atlantic Ocean). To this end, individuals belonging to 3 species showing the widest range of sizes were analysed for muscle delta C-13 and delta N-15 values and muscle Hg, and digestive gland Cd concentrations. Results showed that stable isotope ratios allowed discrimination of specific feeding strategies during ontogenesis. Segregation between 5 cephalopod species in terms of trophic ecology was also evidenced (different isotopic niches). In contrast, Hg concentrations varied over the same order of magnitude in these 5 cephalopod species, despite higher levels in the benthic octopus Eledone cirrhosa. Consistently, Hg concentrations followed the same ontogenic pattern and increased with increasing body size/age of cephalopods. Finally, Cd concentrations varied over 3 orders of magnitude among the 5 species. Despite possible effects of physiology in terms of metal bioaccumulation, Cd concentrations were likely to reflect specific feeding preferences or feeding zones and ontogenic variability within a single species. Thus, ontogenic effects have to be taken into account when stable isotope ratios of carbon and nitrogen or trace metals are used as ecological tracers; the best recommendation being to focus on a given class age.
Marine Ecology Progress Series (0171-8630) (Inter-research), 2011 , Vol. 433 , P. 107-120

Droits : Inter-Research 2011 · www.int-res.com
http://archimer.ifremer.fr/doc/00166/27761/25938.pdf
DOI:10.3354/meps09159
http://archimer.ifremer.fr/doc/00166/27761/

Éditeur(s) : Lunes Lunes ( Havana, Cuba )
Résumé : Editor: 1960-1961 G. Cabrera Infante
Some issues have thematic titles.

Droits : All rights reserved by holding and source institution.
6665413
http://ufdc.ufl.edu/AA00013450/00002