Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
Background: HCV treatment uptake has drastically increased in HIV-HCV coinfected patients in France since direct-acting antiviral (DAA) treatment approval, resulting in HCV cure in 63% of all HIV-HCV patients by the end of 2015. We investigated the impact of scaling-up DAA on HCV prevalence in the whole HIV population and in various risk groups over the next 10 years in France using a transmission dynamic compartmental model.Methods: The model was based on epidemiological data from the French Dat’AIDS cohort. Eight risk groups wereconsidered, including high-risk (HR) and low-risk (LR) men who have sex with men (MSM) and male/female heterosexuals,intra-venous drug users, or patients from other risk groups. The model was calibrated on prevalence and incidence dataobserved in the cohort between 2012 and 2015.Results: On January 1, 2016, 156,811 patients were registered as infected with HIV in France (24,900 undiagnosedpatients) of whom 7938 (5.1%) had detectable HCV-RNA (722 undiagnosed patients). Assuming a treatmentcoverage (TC) rate of 30%/year (i.e., the observed rate in 2015), model projections showed that HCV prevalenceamong HIV patients is expected to drop to 0.81% in 2026. Sub-analyses showed a similar decrease of HIV-HCVprevalence in most risk groups, including LR MSM. Due to higher infection and reinfection rates, predicted prevalencein HR MSM remained stable from 6.96% in 2016 to 6.34% in 2026. Increasing annual TC rate in HR MSM to 50/70%would decrease HCV prevalence in this group to 2.35/1.25% in 2026. With a 30% TC rate, undiagnosed patients wouldaccount for 34% of HCV infections in 2026.Conclusions: Our model suggests that DAA could nearly eliminate coinfection in France within 10 years for most riskgroups, including LR MSM. Elimination in HR MSM will require increased TC.
ISSN: 1741-7015

Droits : info:eu-repo/semantics/OpenAccess
inserm-01685739
http://www.hal.inserm.fr/inserm-01685739
http://www.hal.inserm.fr/inserm-01685739/document
http://www.hal.inserm.fr/inserm-01685739/file/2017%2C%20Virlogeux%20-%20Modeling%20HIV-HCV%20coinfection.pdf
DOI : 10.1186/s12916-017-0979-1

Éditeur(s) : HAL CCSD
Résumé : International audience
Les plages sableuses constituent une frontière mobile et poreuse entre l'océan ouvert et la terre. La compréhension de la circulation dans les nappes de plage est importante pour une variété de processus physiques, biologiques et chimiques. On cherche à caractériser in-situ la dynamique souterraine sous la zone de swash. Le site atelier est la plage microtidale de Rousty (Camargue, France). L'étude, réalisée sur 48h les 13 et 14 décembre 2014, fait partie d'une plus grande campagne de mesure visant à caractériser la réponse hydro-morphologique de la plage de Rousty à une saison hivernale. La période présentée ici correspond à la phase de déclin d'une tempête modérée. La stratégie retenue dans le cadre de ce projet a été de déployer un réseau de15 capteurs de pression enterrés sous la zone de swash. Les caractéristiques des vagues incidentes, à la fois au large et dans la zone de surf interne, ont été mesurées conjointement à l'utilisation d'un LiDAR terrestre haute fréquence permettant de suivre la surface libre et l'évolution du lit sableux à haute fréquence sur la zone de swash. L'analyse des données moyennées dans le temps a mis en évidence la présence d'un schéma de circulation relativement robuste sous la zone de swash, qui se décale vers le large en suivant la descente du niveau moyen et la diminution de l'activité des vagues. La tendancedominante est un écoulement vers le large, avec une intensité maximale de l'ordre de 0.1mm/s modulé par des infiltrations et exfiltrations dans les parties hautes et basses de la zone de swash, respectivement. L'analyse haute fréquence à des événements de swash sélectionnés ont mis en évidence uncycle souterrain caractéristique.
XIV èmes Journées Nationales Génie Côtier – Génie Civil
toulon, France

hal-01357778
https://hal.archives-ouvertes.fr/hal-01357778

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
ObjectivesTo compare the efficacy, in current clinical practice, of ă first regimens containing abacavir with lamivudine (ABC/3TC) or ă tenofovir with emtricitabine (TDF/FTC) in patients with baseline viral ă load 100000 HIV-1 RNA copies/mL. ă MethodsUsing a prospective cohort, we selected all patients starting a ă first HIV regimen based either on ABC/3TC or on TDF/FTC. The propensity ă score (PS) method was used to limit the indication bias due to the ă observational nature of the data. Adjusting and weighting methods via PS ă were used to compare the effectiveness of a first regimen containing ă ABC/3TC or TDF/FTC. The primary outcome was treatment failure by month ă 12 (M12). ă ResultsOverall, 2781 patients started an antiretroviral (ARV) regimen ă with ABC/3TC or TDF/FTC each in combination with efavirenz, boosted ă atazanavir or boosted darunavir. Among the 2472 uncensored patients ă before M12, 962 (39%) had a baseline viral load 100000 copies/mL of ă whom 294 were in treatment failure at or before M12. Our analyses showed ă no difference between ABC/3TC and TDF/FTC in the risk of treatment ă failure at M12 in patients starting an ARV regimen with a high viral ă load (100000 copies/mL). ă ConclusionsUsing a large prospectively collected cohort of patients ă seeking care in France, we found no evidence that ABC/3TC based regimens ă led to more failures than TDF/FTC based ones in patients with high ă baseline viral loads.
ISSN: 1464-2662

hal-01482656
https://hal.archives-ouvertes.fr/hal-01482656
DOI : 10.1111/hiv.12306

Éditeur(s) : HAL CCSD
Résumé : Shoreline and upper beach dynamics under extreme events: the KUNSHEN experiment (Wan Tzu Liao barrier, Taiwan)
PARALIA génie civil & génie côtier

hal-00861950
https://hal.archives-ouvertes.fr/hal-00861950

Éditeur(s) : HAL CCSD Lippincott, Williams & Wilkins
Résumé : International audience
The aim of the study was to investigate the impact of first-line combined antiretroviral therapy (cART) regimen on the course of CD8 + T-cell counts in human immunodeficiency virus (HIV)-infected patients. A retrospective observational study conducted on the French DAT'AIDS Cohort of HIV-infected patients. We selected 605 patients initiating a first-line cART between 2002 and 2009, and which achieved a sustained undetectable HIV plasma viral load (pVL) for at least 12 months without cART modification. The evolution of CD8 + T-cell counts according to cART regimen was assessed. CD8 + T-cell counts were assessed in 572 patients treated with 2NRTIs+1PI/r (n= 297), 2NRTIs+1NNRTI (n= 207) and 3NRTIs (n= 68). In multivariate analysis, after 12 months of follow-up, the 3NRTIs regimen was associated with a significantly smaller decrease of CD8 + T-cell count compared with NNRTI-containing regimens (–10.2 cells/mL in 3NRTIs vs –105.1 cells/mL; P=0.02) but not compared with PI-containing regimens (10.2 vs –60.9 cells/mL; P=0.21). After 24 months, the 3NRTIs regimen was associated with a smaller decrease of CD8 + T-cell count and % compared with PI/r-and NNRTI-containing regimens (0.2 in 3NRTIs vs –9.9 with PI/r-regimens, P=0.001, and vs –11.1 with NNRTI-regimens, p < 0.0001). A focus analysis on 11 patients treated with an INSTI-containing cART regimen during the study period showed after 12 months of follow-up, a median decrease of CD8 + T-cell count of –155 [inter quartile range: –302; –22] cells/mL. Our data highlight the fact that cART regimens have differential effects on CD8 pool down regulation. Abbreviations: cART = combined antiretroviral therapy, HIV = human immunodeficiency virus, INSTI = integrase strand transfer inhibitor, NNRTI = non-nucleotide reverse transcriptase inhibitor, NRTI = nucleotide reverse transcriptase inhibitor, PI/r = Ritonavir-boosted protease inhibitor, pVL = plasma viral load.
ISSN: 0025-7974

inserm-01408002
http://www.hal.inserm.fr/inserm-01408002
http://www.hal.inserm.fr/inserm-01408002/document
http://www.hal.inserm.fr/inserm-01408002/file/2016%2C%20Poizot-Martin%20-%20First-line%20cART%20regimen%20impacts%20the%20course%20of%20CD8%2B%20T-cell%20counts%20in%20HIV-infected%20patients.pdf
DOI : 10.1097/MD.0000000000005087

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
BACKGROUND: Socioeconomic inequalities in cancer mortality have been observed in different European countries and the US until the end of the 1990s, with changes over time in the magnitude of these inequalities and contrasted situations between countries. The aim of this study is to estimate relative and absolute educational differences in cancer mortality in France between 1999 and 2007, and to compare these inequalities with those reported during the 1990s. METHODS: Data from a representative sample including 1% of the French population were analysed. Educational differences among people aged 30--74 were quantified with hazard ratios and relative indices of inequality (RII) computed using Cox regression models as well as mortality rate difference and population attributable fraction. RESULTS: In the period 1999--2007, large relative inequalities were found among men for total cancer and smoking and/or alcohol related cancers mortality (lung, head and neck, oesophagus). Among women, educational differences were reported for total cancer, head and neck and uterus cancer mortality. No association was found between education and breast cancer mortality. Slight educational differences in colorectal cancer mortality were observed in men and women. For most frequent cancers, no change was observed in the magnitude of relative inequalities in mortality between the 1990s and the 2000s, although the RII for lung cancer increased both in men and women. Among women, a large increase in absolute inequalities in mortality was observed for all cancers combined, lung, head and neck and colorectal cancer. In contrast, among men, absolute inequalities in mortality decreased for all smoking and/or alcohol related cancers. CONCLUSION: Although social inequalities in cancer mortality are still high among men, an encouraging trend is observed. Among women though, the situation regarding social inequalities is less favourable, mainly due to a health improvement limited to higher educated women. These inequalities may be expected to further increase in future years.
ISSN: 1471-2458

inserm-00868759
http://www.hal.inserm.fr/inserm-00868759
http://www.hal.inserm.fr/inserm-00868759/document
http://www.hal.inserm.fr/inserm-00868759/file/1471-2458-13-823.pdf
DOI : 10.1186/1471-2458-13-823

Éditeur(s) : Actes de Innovations et sociétés Séminaire du 13 au 16 septembre 1993, Montpellier -France
Résumé : Taking into account the complexity in renewable natural resources exploitation makes innovation challenge researchers. This paper transposes some theoritical aspects of innovation process in fishery context system. Before explaining "emergence potential" and its adaptative conditions, a framework of analysis is choosed with respect to a systemic approach. A screen is proposed and examples are exposed in fishery sector both in developing and industrialized countnes. This analysis brings out questions about the role of developers and researchers in the fishery system. [NOT CONTROLLED OCR]
Devant la complexité des modes d'exploitation des ressources naturelles renouvelables, les tentatives "d'innovation" interpèlent et interrogent le chercheur. Cette contribution envisage tout d'abord la transposition de certains développements théoriques de l'étude des processus d'innovation au contexte particulier des systèmes halieutiques. L'objectif est de construire un cadre d'analyse conciliable avec une approche de type systémique avant de tenter de rapprocher les processus d'innovation du potentiel d'émergence d'un système et de ses conditions d'adaptabilité. Il sera donc proposé une grille· de lecture ainsi qu'une série d'exemples concrets, tant dans des pêcheries des pays développés que des pays en voie de développement, analysés au travers de cette typologie. Cette analyse débouche sur une réflexion sur l'ambiguïté du rôle du développeur dans le contexte des systèmes halieutiques et donc sur celui du chercheur. [OCR NON CONTRÔLE]

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/1993/acte-4159.pdf
http://archimer.ifremer.fr/doc/00000/4159/

Éditeur(s) : HAL CCSD Taylor & Francis (Routledge): STM, Behavioural Science and Public Health Titles
Résumé : International audience
The aim of this study was to determine factors associated with complete satisfaction with the care provided (satisfaction with physicians and satisfaction with services and organization) among HIV-infected patients followed up in the French ANRS CO8 APROCO-COPILOTE cohort. Analyses focused on cross-sectional data collected during the ninth year of cohort follow-up. Satisfaction with care, sociodemographic characteristics, and behavioral data were collected using self-administered questionnaires, while clinical data were derived from medical records. Complete satisfaction with care was defined as being 100% satisfied. Two logistic regression models were used to identify predictors of (1) complete satisfaction with physicians (n=404) and (2) complete satisfaction with services and organization (n=396). Sixteen percent of patients were completely satisfied with physicians, while 15.9% were completely satisfied with services and organization. Being older and reporting fewer discomforting antiretroviral therapy (ART) side effects were factors independently associated with complete satisfaction with both physicians and services and organization. Strong support from friends and absence of hepatitis C (HCV) co-infection were independently associated with complete satisfaction with physicians, while strong support from one's family and comfortable housing conditions were independently associated with complete satisfaction with services and organization. Even after nine years of follow-up, social vulnerabilities still strongly influence HIV-infected patients' interactions with the health care system. Day-to-day experience with the disease, including perceived treatment side effects, appears to play a key role in the quality of these interactions. More attention should be given to patient satisfaction, especially for socially vulnerable patients, in order to avoid potentially detrimental consequences such as poor adherence to ART.
AIDS Care

hal-00875619
https://hal.archives-ouvertes.fr/hal-00875619
DOI : 10.1080/09540121.2011.613909
PUBMED : 21999644

Éditeur(s) : HAL CCSD Editions Paralia CFL
Résumé : Barrier island hydro-morphodynamics driven by typhoon events are the major concern of the project KUNSHEN (2011-2014). It aims at providing for a deep understanding of the peculiar dynamics of sand barriers where extreme events such as typhoons have a significant impact. We present the campaigns and the protocols achieved and planned in the project, on the Wan-tzu-liao sand barrier, Cigu Lagoon, Tainan, Taiwan, from October 2011 to January 2012, during the winter storm season and during summer 2012 during the typhoon season. A set of current profilers are deployed along a cross shore transect at 7, 4 and 2 meters deep. On the Wan-tzu-liao sand barrier, 3 columns of 3 pressiometers are deployed to survey the submersion. In the same time, morphological surveys are performed on the sand barrier with DGPS to analyse any change in the shoreline position, the beach slope, and the dynamics of sand beach features. A very preliminary analysis on these on-going field surveys suggests that the word "extreme" refers more to the consequence of the forcing on the sand barrier than the intensity of the forcing itself. The strategy developed in this first step will be refined to survey the next typhoon season, from May 2012 to October 2012.
ISSN: 1760-8716

hal-00854411
https://hal.archives-ouvertes.fr/hal-00854411
DOI : 10.5150/jngcgc.2012.034-M

Éditeur(s) : HAL CCSD Coastal Education and Research Foundation
Résumé : The sinking of the Prestige tanker (November, 2002) spilled over 64000 tons of heavy fuel oil. The Prestige oil spill (POS) affected approximately 1000 km of coast belonging to Portugal, France and Spain and more than 600 sandy beaches were polluted along the Atlantic coast of Spain. Since POS, yearly surveys of two oiled sandy beaches (Galicia, NW Spain) have provided evidences regarding the oil pollution behavior and the influence of beach morphodynamics on the dynamics of the contamination. The analysis of wave climate, the extracted suction cores and the detected oil from 2004 and 2009 fieldworks have allowed to promote a conceptual model of the influence of beach morphodynamics on the first steps of an oil spill and to establish the effects on the long-term oil pollution
ISSN: 0749-0208

hal-00783182
https://hal.archives-ouvertes.fr/hal-00783182

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
BACKGROUND: Thrombophilias are common disorders that increase the risk of pregnancy-associated venous thromboembolism and pregnancy loss and can also increase the risk of placenta-mediated pregnancy complications (severe pre-eclampsia, small-for-gestational-age infants, and placental abruption). We postulated that antepartum dalteparin would reduce these complications in pregnant women with thrombophilia. METHODS: In this open-label randomised trial undertaken in 36 tertiary care centres in five countries, we enrolled consenting pregnant women with thrombophilia at increased risk of venous thromboembolism or with previous placenta-mediated pregnancy complications. Eligible participants were randomly allocated in a 1:1 ratio to either antepartum prophylactic dose dalteparin (5000 international units once daily up to 20 weeks' gestation, and twice daily thereafter until at least 37 weeks' gestation) or to no antepartum dalteparin (control group). Randomisation was done by a web-based randomisation system, and was stratified by country and gestational age at randomisation day with a permuted block design (block sizes 4 and 8). At randomisation, site pharmacists (or delegates) received a randomisation number and treatment allocation (by fax and/or e-mail) from the central web randomisation system and then dispensed study drug to the local coordinator. Patients and study personnel were not masked to treatment assignment, but the outcome adjudicators were masked. The primary composite outcome was independently adjudicated severe or early-onset pre-eclampsia, small-for-gestational-age infant (birthweight <10th percentile), pregnancy loss, or venous thromboembolism. We did intention-to-treat and on-treatment analyses. This trial is registered with ClinicalTrials.gov, number NCT00967382, and with Current Controlled Trials, number ISRCTN87441504. FINDINGS: Between Feb 28, 2000, and Sept 14, 2012, 292 women consented to participate and were randomly assigned to the two groups. Three women were excluded after randomisation because of ineligibility (two in the antepartum dalteparin group and one in the control group), leaving 146 women assigned to antepartum dalteparin and 143 assigned to no antepartum dalteparin. Some patients crossed over to the other group during treatment, and therefore for on-treatment and safety analysis there were 143 patients in the dalteparin group and 141 in the no dalteparin group. Dalteparin did not reduce the incidence of the primary composite outcome in both intention-to-treat analysis (dalteparin 25/146 [17.1%; 95% CI 11.4-24.2%] vs no dalteparin 27/143 [18.9%; 95% CI 12.8-26.3%]; risk difference -1.8% [95% CI -10.6% to 7.1%)) and on-treatment analysis (dalteparin 28/143 [19.6%] vs no dalteparin 24/141 [17.0%]; risk difference +2.6% [95% CI -6.4 to 11.6%]). In safety analysis, the occurrence of major bleeding did not differ between the two groups. However, minor bleeding was more common in the dalteparin group (28/143 [19.6%]) than in the no dalteparin group (13/141 [9.2%]; risk difference 10.4%, 95% CI 2.3-18.4; p=0.01). INTERPRETATION: Antepartum prophylactic dalteparin does not reduce the occurrence of venous thromboembolism, pregnancy loss, or placenta-mediated pregnancy complications in pregnant women with thrombophilia at high risk of these complications and is associated with an increased risk of minor bleeding. FUNDING: Canadian Institutes of Health Research, Heart and Stroke Foundation of Canada, and Pharmacia and UpJohn.
ISSN: 0923-7577

hal-01258557
http://hal.univ-brest.fr/hal-01258557
DOI : 10.1016/S0140-6736(14)60793-5
PUBMED : 25066248

Éditeur(s) : HAL CCSD Editions Paralia CFL
Résumé : Le lido de Villeneuve-lès-Maguelone (Languedoc-Roussillon) est un archétype de littoral microtidal, dominé par la houle, en érosion, et largement affecté par la submersion marine lors des tempêtes. Les observations réalisées dans le cadre du Système d'Observation Littoral - Trait de Côte (SO LTC) concernent l'hydrodynamique et le transport sédimentaire dans l'avant-côte et la lagune. La tache d'observation MAGOBS (Observatoire Aresquiers-Maguelone-Palavas) de cet observatoire regroupe un dispositif instrumental automatisé composé de 30 points d'acquisition en temps réel entre 6 mètres de profondeur et le haut de plage (à terre) ainsi que dans la lagune. Le dispositif est opérationnel depuis mai 2011. Son déploiement a permis de déverrouiller les difficultés techniques liées à la mesure temps réel en zone littorale : choix du type des appareils de mesure, de la technologie embarquée, des cadences d'acquisition, résolution des questions du transfert de la donnée. Le dispositif produit 2 Tera-octets de données par an. Les données sont stockées sur un ensemble de serveurs dédiés. Les données sont mises en ligne sur le site du SO-LTC (www.soltc.org), immédiatement après premiers traitements et qualification. Elles commencent à être utilisées pour des calculs de niveau d'eau à la côte, et dansdes outils de prédiction des vagues et des niveaux à la côte associant mesure et modélisation.
ISSN: 1760-8716

hal-00854410
https://hal.archives-ouvertes.fr/hal-00854410
DOI : 10.5150/jngcgc.2012.064-G

Éditeur(s) : HAL CCSD
Résumé : International audience
This communication reports on a field experiment carried out on a microtidal beach in Camargue, France. The analysis is built on the initial work presented by Sous et al. (2016) on swash-groundwater dynamics. The analysis of a cross-shore network of buried pressure sensors allows to monitor the watertable dynamics over the full 2013-2014 winter season. The pressure head gradients are observed to be primarily seaward, forced by a higher level at the landward boundary. The groundwater flux is driven by the relative fluctuations of Still Water Level and inland elevations. Rain and tides have a little effect. A nearly isolated groundwater circulation is driven by wave activity below the swash zone whatever the overall watertable gradient. Estimations of beach groundwater discharge over the Gulf of Beauduc reveal the importance of beach groundwater in the exchanges between coastal aquifer and open sea.
Coastal Dynamics 2017
Helsingor, Denmark

hal-01562908
https://hal.archives-ouvertes.fr/hal-01562908

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Cytomegalovirus (CMV) infection is common among HIV-infected patients but its repercussion on the course of CD4+ and CD8+ T cells after cART initiation remains elusive. The French Dat'AIDS cohort enrolled 5,688 patients on first-line cART, from which we selected patients who achieved HIV suppression for at least 12 months without modification of cART, and for whom CMV serostatus was available. Five hundred and three patients fulfilled the selection criteria (74% male, median age 43 yrs, 15.5% CDC stage C), of whom 444 (88.3%) were seropositive for CMV (CMV+). Multivariate analyses using mixed-linear models adjusted for the time from HIV suppression, sex, age, transmission risk group, duration of HIV follow-up, the interaction between time from HIV suppression and CMV+ serol-ogy, and the nadir CD4 count revealed a negative correlation between CMV+ and CD4: CD8 ratio (coeff. =-0.16; p = 0.001). This correlation was also observed among patients displaying optimal CD4 recovery (!500 cells/mm3 at M12; coeff. =-0.24; p = 0.002). Hence, CMV+ serostatus antagonizes normalization of the CD4:CD8 ratio, although further analyses of the impact of co-morbidities that associate with CMV serostatus, like HCV infection, are needed to elucidate this antagonism formally. However, this might reflect a premature T cell senescence, thus advocating for a close monitoring of T cells in CMV co-infected patients. In addition, our results raise the question of the benefit of treatment for asymptomatic CMV co-infection in HIV-infected patients.
ISSN: 1932-6203

inserm-01418700
http://www.hal.inserm.fr/inserm-01418700
http://www.hal.inserm.fr/inserm-01418700/document
http://www.hal.inserm.fr/inserm-01418700/file/journal.pone.0165774.PDF
DOI : 10.1371/journal.pone.0165774

Éditeur(s) : HAL CCSD
Résumé : International audience
This work aims to better understand the physical processes governing the wave propagation in a vertically shearedcurrent and the resulting nearshore circulation patterns. It is based on a high resolution hydro-morphodynamic fieldcampaign, ROUSTY2014, collecting a comprehensive hydro-morphodynamical dataset during a full winter season.The overall analysis highlights three main circulation patterns, largely controled by the bathymetric features and byco-working or competing wind and waves forcings. Regarding the vertical structuration of the circulation, most of fieldobservations shown seaward directed circulation with onshore component close to the air/sea surface whose intensityvaries according to incoming wave conditions. Forth, vertical shear increase when breaking happen close to sensorlocation and orientation of mean circulation depend on wind direction.
35th International Conference on Coastal Engineering
Antalya, Turkey

hal-01426582
https://hal.archives-ouvertes.fr/hal-01426582

Éditeur(s) : HAL CCSD
Résumé : International audience
This communication reports on a field experiments carried out on the Ouano reef barrier, New Caledonia. The analysis is based on a cross-shore network of pressure sensors deployed across the reef flat and within the lagoon. Confirming existing observations, the measurements show the strong filtering role of the reef barrier on the incoming wave energy The swell energy is dissipated and transferred toward lower frequencies, including the so-called infragravity (IG) and very low frequency (VLF) waves. During energetic event (Hs=4.2m), IG and VLF significant wave heights on the reef flat are observed to reach 1.2 and 0.7m, respectively. A variety of long waves modes are observed on the reef, combining standing and progressive-dissipative modes. In any cases, the VLF and IG waves are much more developed over and close to the reef flat than further inside the lagoon.
Coastal Dynamics 2017
Helsingor, Denmark

hal-01562927
https://hal.archives-ouvertes.fr/hal-01562927

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Yearly monitoring in one of the most affected coastal zones by the Prestige oil spill, namely Nemiña and O Rostro beaches (NW Spain), has been carried out since 2004. Topographic data of beaches revealed seasonal altimetric changes up to 4 m that would prevent the on shore persistence of oil. However, surficial and subsurficial oil was detected in the intertidal area of both beaches in all campaigns. The hydrocarbon analysis confirmed that this oil corresponded to the Prestige oil, even nine years after the accident. Tar balls were highly biodegraded suggesting that the oil was accumulated on the subtidal sediments for a long time and transported to the coast by the action of waves. The present work provides new evidence of the long term persistence of deep oil spills from wrecks in marine areas where the hydrodynamic conditions play a twofold key role, in determining the exposed coastal area to recurrent contamination and in burying and resurfacing the oil in the intertidal zone.
ISSN: 0304-3894

hal-01071707
https://hal.archives-ouvertes.fr/hal-01071707
DOI : 10.1016/j.jhazmat.2013.01.057

Éditeur(s) : Pêche thonière et dispositifs de concentration de poissons, Caribbean-Martinique, 15-19 Oct 1999 15-19 octobre 1999
Résumé : The first fad's in the islands of the South West Indian Ocean were moored in the fifties. The area under study forms part of the Indian Ocean Commission which include Comoros, Madagascar, Mauritius, Seychelles, Reunion and the island of Mayotte. After a few isolated trials that turned to be inconclusive, especially for lack of reliability of the devices moored, trials were pursued under the auspices of International Organizations. A new type of fad was successfully designed and implemented in Mauritius. This model was then applied in the Comoros in 1987, in la Reunion and Madagascar in 1988 and in Mayotte in 1989. The various programmes have had various results. In some cases such as la Reunion and Mauritius, they have played a key role in the development of the inshore fishery. In other cases they have been less significant. Finally in other cases although a significant impact on artisanal fishery, the experience was halted due to financial constraints. Beyond the history of the various programmes and the results obtained, the authors have attempted to underline the social and economic factors that have characterized the various trials in the different regional countries.

Droits : Ifremer
http://archimer.ifremer.fr/doc/00042/15285/12671.pdf
http://archimer.ifremer.fr/doc/00042/15285/

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
BACKGROUND: Human immunodeficiency virus (HIV)-infected patients have decreased immune response to vaccines. Few data are available about pandemic flu vaccination in this population. METHODS: We conducted a multicenter, patient-blinded, randomized trial in a cohort of HIV-infected adults. Patients received 2 injections 21 days apart of a AS03(A)-adjuvanted H1N1v vaccine containing 3.75 μg hemagglutinin (HA) or a nonadjuvanted H1N1v vaccine containing 15 μg HA to assess hemagglutination inhibition (HI) response and safety. RESULTS: A total of 309 patients were randomized, and 306 were vaccinated. After the first vaccine dose, HI titers ≥1:40 were observed in 93.4% of the patients in the adjuvanted group (A group) (n = 155) and in 75.5% in the nonadjuvanted group (B group) (n = 151) (P < .001); seroconversion rates were 88.8% and 71.2%, and factor increases in geometric mean titers (GMT) of 21.9 and 15.1, respectively. After 2 injections, 98.6% of patients of the A group and 92.1% of the B group demonstrated HI titers ≥1:40 (P = .018); seroconversion rates were 96.5% and 87.1%, respectively, and factor increases in GMT were 45.5 and 21.2, respectively. The majority of adverse events were mild to moderate in severity; no impact on CD4+ cell count or viral load has been detected. CONCLUSIONS: In HIV-1-infected adults, the AS03(A)-adjuvanted H1N1v vaccine yielded a higher immune response than did the nonadjuvanted one, with no impact on HIV infection.
ISSN: 0022-1899

hal-00875299
https://hal.archives-ouvertes.fr/hal-00875299
DOI : 10.1093/infdis/jir211
PUBMED : 21628666

Éditeur(s) : HAL CCSD
Résumé : National audience
Introduction Les données sur l’efficacité virologique et la tolérance à long terme de l’association abacavir/lamivudine (ABC/3TC) et nevirapine (NVP) sont rares.
Médecine et maladies infectieuses 46 (2016) 5-7
Lille, France

Droits : info:eu-repo/semantics/OpenAccess
inserm-01414591
http://www.hal.inserm.fr/inserm-01414591
http://www.hal.inserm.fr/inserm-01414591/document
http://www.hal.inserm.fr/inserm-01414591/file/2016%2C%20de%20Boissieu%20-%20COL%203-04.pdf
PUBMED : 27495405