Éditeur(s) : HAL CCSD Landes Bioscience
Résumé : International audience
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
Autophagy

hal-00735751
https://hal.archives-ouvertes.fr/hal-00735751
PUBMED : 22966490

Éditeur(s) : HAL CCSD Météo et Climat
Résumé : International audience
D'initiative française, le projet international HyMeX a pour objectif d'améliorer la compréhension du cycle de l'eau en Méditerranée, de sa variabilité, de l'échelle de l'événement météorologique aux échelles saisonnières et interannuelles, et de ses caractéristiques sur une décennie, dans un contexte de changement global. Le projet est motivé par le rôle déterminant des processus de mésoéchelle, couplés entre l'atmosphère, la mer et la terre, sur la variabilité du système climatique et sur le déclenchement d'événements hydrométéorologiques extrêmes (précipitations et inondations, vents forts et convection océanique, canicules et sécheresses). Le projet vise enfin à évaluer les conséquences de ces événements extrêmes sur la vulnérabilité sociale et économique de cette région et sa capacité d'adaptation.
ISSN: 0026-1181

hal-00828758
https://hal.archives-ouvertes.fr/hal-00828758
https://hal.archives-ouvertes.fr/hal-00828758/document
https://hal.archives-ouvertes.fr/hal-00828758/file/meteo_2013_80_23%20%281%29.pdf
DOI : 10.4267/2042/48792

Éditeur(s) : HAL CCSD springer Link
Résumé : International audience
Experimental Astronomy

hal-01094521
https://hal.archives-ouvertes.fr/hal-01094521
BIBCODE : 2014ExA...tmp...41R
DOI : 10.1007/s10686-014-9383-4
ARXIV : 1310.0696

Éditeur(s) : HAL CCSD Association des Géographes Français
Résumé : International audience
Cet article résume les résultats des tables rondes et de 41 contributions de chercheurs français et étrangers au colloque international « Croissance urbaine et risques naturels» qui s'est déroulé à l'Université Blaise-Pascal, Clermont-Ferrand, les 2 et 3 décembre 1994.L'objectif général du colloque était de rassembler les diverses compétences existant en France et à l'étranger dans le domaine de l'évaluation et de la gestion des risques naturels et de confronter les expériences acquises à l'interface entre les villes en croissance et le champ d'action des phénomènes naturels créateurs de risques. Le colloque a donc réuni des chercheurs, des doctorants et des praticiens de 12 pays, chargés de prévention, de gestion des risques naturels et de gestion urbaine, principalement dans les grandes villes des pays en développement.Les contributions ont été regroupées, exposées et discutées lors du colloque sous forme de 3 thèmes : (1) Les phénomènes naturels créateurs de dommages (= menaces) : diagnostic, inventaire et typologie, (2) Les vulnérabilités des sociétés et des espaces urbanisés : concepts, typologie et modes d'analyse, (3) Les outils d'aide à la prévention et à la gestion du risque en milieu urbain.
ISSN: 0004-5322

hal-01165458
https://hal.archives-ouvertes.fr/hal-01165458
https://hal.archives-ouvertes.fr/hal-01165458/document
https://hal.archives-ouvertes.fr/hal-01165458/file/article_bagf_0004-5322_1995numéro 72_4_1843.pdf

Éditeur(s) : HAL CCSD BRGM
Résumé : National audience
Proceedings 1ère Journée 'Alea Gravitaire'
Orléans, France

hal-00533951
https://hal.archives-ouvertes.fr/hal-00533951

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
This work describes the history of late Pleistocene glaciations in the central Sayan-Tuva Upland (southern Siberia). Geological and geomorphological analysis as well as 10Be surface-exposure dating revealed the glacier fluctuations in this continental area. The available published data show that the glaciers were formed in the MIS 6 and probably survived in the MIS 5. Data are also available concerning glacial advances in different periods of MIS 4, MIS 3 and MIS 2. ELAs were 2030-2230 m. Two distinct 10Be exposure ages groups are highlighted reflecting the time of formation of glacial deposits in the MIS 2 associated to the Big Sayan Ridge outlet glaciers. The Sentsa - Sailag group (terminal moraine) has a mean exposure age of 16.44 ± 0.38 ka. The Jombolok (terminal moraine) - Jombolok (outwash plain) group has a mean exposure age of 22.80 ± 0.56 ka. The last glaciation that occurred at MIS 2 is characterized by the absence of ice cap on the Azas volcanic Plateau and of ice field in the Todza Basin. The thickness of the valley glacier was 300-400 m. At MIS 2, the terminal moraines were ∼1300-1400 m a.s.l. in the Tissa, Sentsa, Jombolok and Sailag river valleys.
ISSN: 0277-3791

hal-00758082
https://hal.archives-ouvertes.fr/hal-00758082
DOI : 10.1016/j.quascirev.2012.06.005

Éditeur(s) : HAL CCSD Société géologique de France
Résumé : National audience
The late Lower to Middle Permian Panjal Traps (NW Himalaya, India-Pakistan) represent the greatest magmatic province erupted on the northern Indian platform during the Neotethys opening. New geochemical and isotopic analyses were performed on basalts from the eastern borders of the traps (SE Zanskar-NW Spiti area) in order to characterize this volcanism, to discuss its compositional variations in comparison to Panjal counterparts and its relationships with the opening of Neotethys. Lavas show features of tholeiitic low-Ti (< 1.6%) continental flood basalts with LREE, Th enrichments and Nb-Ta negative anomalies. Trace element ratios combined with {varepsilon}Ndi values (–3.6 to +0.9) and high Pb isotopic ratios suggest that these tholeiitic basalts were derived from an OIB-like mantle contaminated at various degrees by a continental crust component. Previous geochemical features are broadly similar to those of the coeval Panjal volcanic sequences identified westwards (Ladakh, Kashmir and Pakistan). Present geochemical constraints obtained for the Panjal Traps basalts suggest they originated from rapid effusion of tholeiitic melts during opening of the Neotethys Ocean. Similar magmatism implying an OIB-type reservoir is contemporaneously recognized on and along the adjacent Arabian platform. Both Indian and Arabian Permian volcanics were emplaced during coeval syn-rift to post rift transition. These Lower to Middle Permian south Neotethyan continental flood magmatism are regarded as associated to a passive rifting. In this scheme, OIB-type isotopic signature would be related either to a melting episode of syn-rift up-welling mantle plumes or to a melting of a regional abnormally hot and enriched mantle.
EISSN: 1777-5817

insu-00338862
https://hal-insu.archives-ouvertes.fr/insu-00338862
DOI : 10.2113/gssgfbull.179.4.383

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The presence of two regional seismic networks in southeastern France provides us high-quality data to investigate upper mantle flow by measuring the splitting of teleseismic shear waves induced by seismic anisotropy. The 10 three-component and broadband stations installed in Corsica, Provence, and western Alps efficiently complete the geographic coverage of anisotropy measurements performed in southern France using temporary experiments deployed on geodynamic targets such as the Pyrenees and the Massif Central. Teleseismic shear waves (mainly SKS and SKKS) are used to determine the splitting parameters: the fast polarization direction and the delay time. Delay times ranging between 1.0 and 1.5 s have been observed at most sites, but some larger delay times, above 2.0 s, have been observed at some stations, such as in northern Alps or Corsica, suggesting the presence of high strain zones in the upper mantle. The azimuths of the fast split shear waves define a simple and smooth pattern, trending homogeneously WNW–ESE in the Nice area and progressively rotating to NW–SE and to NS for stations located further North in the Alps. This pattern is in continuity with the measurements performed in the southern Massif Central and could be related to a large asthenospheric flow induced by the rotation of the Corsica–Sardinia lithospheric block and the retreat of the Apenninic slab. We show that seismic anisotropy nicely maps the route of the slab from the initial rifting phase along the Gulf of Lion (30–22 Ma) to the drifting of the Corsica–Sardinia lithospheric block accompanied by the creation of new oceanic lithosphere in the Liguro–Provençal basin (22–17 Ma). In the external and internal Alps, the pattern of the azimuth of the fast split waves follows the bend of the alpine arc. We propose that the mantle flow beneath this area could be influenced or perhaps controlled by the Alpine deep penetrative structures and that the Alpine lithospheric roots may have deflected part of the horizontal asthenospheric flow around its southernmost tip.
ISSN: 0040-1951

hal-00109313
https://hal.archives-ouvertes.fr/hal-00109313
https://hal.archives-ouvertes.fr/hal-00109313/document
https://hal.archives-ouvertes.fr/hal-00109313/file/barruol_TGRS_Tphy2004_hal.pdf
DOI : 10.1016/j.tecto.2004.08.002

Éditeur(s) : HAL CCSD
Résumé : International audience
Studies report that foetal exposure to paracetamol by maternal consumption can interfere with male reproductive development. Moreover, recent biomonitoring data report widespread presence of paracetamol in German and Danish populations, suggesting exposure via secondary (non-pharmaceutical) sources such as metabolic conversion from the ubiquitous industrial compound aniline. In this study we investigated the extent to which paracetamol and aniline can interfere with female reproductive development. Intrauterine exposure to paracetamol by gavage of pregnant dams resulted in shortening of the anogenital distance in adult offspring, suggesting that foetal hormone signalling had been disturbed. Female offspring of paracetamol-exposed mothers had ovaries with diminished follicle reserve and reduced fertility. Foetal gonads of exposed animals had also reduced gonocyte numbers, suggesting that the reduced follicle count in adults could be due to early disruption of germ cell development. However, ex vivo cultures of ovaries from 12.5 days post coitum foetuses showed no decrease in proliferation or expression following exposure to paracetamol. This suggests that the effect of paracetamol occurs prior to this developmental stage. Accordingly, using embryonic stem cells as a proxy for primordial germ cells we show that paracetamol is an inhibitor of cellular proliferation, but without cytotoxic effects. Collectively, our data show that intrauterine exposure to paracetamol at levels commonly observed in pregnant women, as well as its precursor aniline, may block primordial germ cell proliferation, ultimately leading to reduced follicle reserves and compromised reproductive capacity later in life
Toxicological Sciences

hal-01259211
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01259211
DOI : 10.1093/toxsci/kfv332
PUBMED : 26732887

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The eastern part of the Cordillera Occidental of Ecuador comprises thick buoyant oceanic plateaus associated with island-arc tholeiites and subduction-related calc-alkaline series, accreted to the Ecuadorian Continental Margin from Late Cretaceous to Eocene times. One of these plateau sequences, the Guaranda Oceanic Plateau is considered as remnant of the Caribbean–Colombian Oceanic Province (CCOP) accreted to the Ecuadorian Margin in the Maastrichtien. Samples studied in this paper were taken from four cross-sections through two arc-sequences in the northern part of the Cordillera Occidental of Ecuador, dated as (Río Cala) or ascribed to (Macuchi) the Late Cretaceous and one arc-like sequence in the Chogòn-Colonche Cordillera (Las Orquídeas). These three island-arcs can clearly be identified and rest conformably on the CCOP. In all four localities, basalts with abundant large clinopyroxene phenocrysts can be found, mimicking a picritic or ankaramitic facies. This mineralogical particularity, although not uncommon in island arc lavas, hints at a contribution of the CCOP in the genesis of these island arc rocks. The complete petrological and geochemical study of these rocks reveals that some have a primitive island-arc nature (MgO values range from 6 to 11 wt.%). Studied samples display marked Nb, Ta and Ti negative anomalies relative to the adjacent elements in the spidergrams characteristic of subduction-related magmatism. These rocks are LREE-enriched and their clinopyroxenes show a tholeiitic affinity (FeOT–TiO2 enrichment and CaO depletion from core to rim within a single crystal). The four sampled cross-sections through the island-arc sequences display homogeneous initial Nd, and Pb isotope ratios that suggest a unique mantellic source for these rocks resulting from the mixing of three components: an East-Pacific MORB end-member, an enriched pelagic sediment component, and a HIMU component carried by the CCOP. Indeed, the ankaramite and Mg-basalt sequences that form part of the Caribbean-Colombian Oceanic Plateau are radiogenically enriched in 206Pb/204Pb and 207Pb/204Pb and contain a HIMU component similar to that observed in the Gorgona basalts and Galápagos lavas. The subduction zone that generated the Late Cretaceous arcs occurred far from the continental margin, in an oceanic environment. This implies that no terrigenous detrital sediments interacted with the source at this period. Thus, the enriched component can only result from the melting of subducted pelagic sediments. We have thus defined the East-Pacific MORB, enriched (cherts, pelagic sediments) and HIMU components in an attempt to constrain and model the genesis of the studied island-arc magmatism, using a compilation of carefully selected isotopic data from literature according to rock age and paleogeographic location at the time of arc edification. Tripolar mixing models reveal that proportions of 12–15 wt.% of the HIMU component, 7–15 wt.% of the pelagic sediment end-member and 70–75 wt.% of an East-pacific MORB end-member are needed to explain the measured isotope ratios. These surprisingly high proportions of the HIMU/CCOP component could be explained by the young age of the oceanic plateau (5–15 Ma) during the Late Cretaceous arc emplacement. The CCOP, basement of these arc sequences, was probably still hot and easily assimilated at the island-arc lava source.
ISSN: 0895-9811

insu-00353692
https://hal-insu.archives-ouvertes.fr/insu-00353692
DOI : 10.1016/j.jsames.2008.06.003

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
In the South Tien Shan range (Kyrgyzstan), the Late Paleozoic geodynamic evolution remains debated especially to the west of the Talas-Fergana fault (TFF) fault where suture-related high-pressure (HP) rocks are scarce. We provide new petrological and geochronological data on garnet amphibolites from the Chatkal range, to the west of the TFF, northwest of the South Tien Shan suture. These rocks are retrogressed eclogites. We used a micro-mapping approach combined with forward modeling and empirical thermobarometry to decipher the P–T path of these amphibolitized eclogites. The metamorphic peak conditions culminated at 490 ± 50 °C and 18.5 ± 2 kbar and were followed by higher temperature retrogression (∼560 °C at 11–7 kbar). In order to constrain the age of the HP stage, we dated allanite crystals texturally coeval to the HP mineral assemblage. Allanite grains dated in situ with a U–Pb LA-ICPMS methodology yield an age of 301 ± 15 Ma. Compared with previously published data for the east of the TFF, these P–T constraints allow improving the understanding of the Late Paleozoic geodynamic evolution of the South Tien Shan. To the east of TFF, the Turkestan Ocean closed around 320 Ma with the collision of the Tarim Craton with the Kazakh microcontinent. To the west of TFF, the Turkestan Ocean closed around 300 Ma, when the Alai block collided with the Kazakh microcontinent. This later collision involved nappe-stacking and intense subvertical folding in the western South Tien Shan. This complex folding explains the S-shape of the suture to the west of the TFF that cannot be observed in the eastern part. These new data allow us to propose a distinct tectonic evolution of the two sides of the TFF, which suggests that this fault was a major transform fault before being a strike-slip intra-continental fault.
ISSN: 0264-3707

hal-01347171
https://hal.archives-ouvertes.fr/hal-01347171
DOI : 10.1016/j.jog.2015.06.005

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Subduction processes play a major role in plate tectonics and the subsequent geological evolution of Earth. This special issue focuses on ongoing research in subduction dynamics to a large extent (oceanic subduction, continental subduction, obduction…) for both past and active subduction zones and into mountain building processes and the early evolution of orogens. It puts together various approaches combining geophysics (imaging of subduction zones), petrology/geochemistry (metamorphic analysis of HP-UHP rocks, fluid geochemistry and magmatic signal, geochronology), seismology and geodesy (present-day evolution of subduction zones, active tectonics), structural geology (structure and evolution of mountain belts), and numerical modelling to provide a full spectrum of tools that can be used to constrain the nature and evolution of subduction processes and orogeny. Studies presented in this special issue range from the long-term (orogenic cycle) to short-term (seismic cycle).
ISSN: 0264-3707

insu-01287985
https://hal-insu.archives-ouvertes.fr/insu-01287985
https://hal-insu.archives-ouvertes.fr/insu-01287985/document
https://hal-insu.archives-ouvertes.fr/insu-01287985/file/rolland-2016.pdf
DOI : 10.1016/j.jog.2016.03.006

Éditeur(s) : HAL CCSD
Résumé : Xth world conference SEA 2016, Rome, 13-15 juin 2016
https://hal-agroparistech.archives-ouvertes.fr/hal-01504655

hal-01504655
https://hal-agroparistech.archives-ouvertes.fr/hal-01504655

Éditeur(s) : HAL CCSD Association pour la diffusion de la recherche alpine
Résumé : International audience
Le thème des vulnérabilités des sociétés et des espaces urbanisés est abordé à partir de la vingtaine de communications qui, au cours du colloque de Clermont-Ferrand ont traité de cette question (Colloque international : "Croissance urbaine et risques naturels dans les pays en développement", Université Blaise Pascal, Clermont-Ferrand, 2-3 décembre 1994). Dans un premier temps, la synthèse présente les concepts et les différentes approches de la vulnérabilité. Un regard critique est ensuite porté sur la relation entre l’évaluation et la réduction de la vulnérabilité. Enfin, les possibilités de convergence entre les différentes approches sont examinées et des pistes de recherche sont lancées.
EISSN: 1760-7426

Droits : info:eu-repo/semantics/OpenAccess
hal-01164931
https://hal.archives-ouvertes.fr/hal-01164931
https://hal.archives-ouvertes.fr/hal-01164931/document
https://hal.archives-ouvertes.fr/hal-01164931/file/article_rga_0035-1121_1994numéro 82_4_3776.pdf
DOI : 10.3406/rga.1994.3776

Éditeur(s) : HAL CCSD American Geophysical Union
Résumé : International audience
Knowing the slip amplitudes that large earthquakes produced in prehistorical times is one key to anticipate the magnitude of large forthcoming events. It is long known that the morphology is preserving remnants of paleoearthquake slips in the form of fault-offset landforms. However, the measured offsets that can be attributed to the most recent paleoearthquakes are generally few along a fault, so that they rarely allow recovering the slip distributions and largest slips of these earthquakes. We acquired ~1 m resolution airborne lidar data on a 30 km stretch of a fast-slipping strike-slip fault (eastern Hope Fault, New Zealand) located in a region of high alluvial dynamics where landforms are rapidly evolving. Data analysis reveals >200 offset landforms; only 30% allow a good to moderate quality offset measurement. From these good to moderate quality measures, we recover the slip-length distributions and largest slips of the four most recent large paleoearthquakes and find evidence of 4–6 prior events. The record suggests that large earthquake slip recurred in multiples of about 4 m along the 30 km stretch. Although they have larger uncertainties, the more numerous lower-quality offsets that we also measured reveal a similar earthquake slip record. This shows that, although offset landforms are partly degraded in dynamically active landscapes, they store valuable information on paleoearthquake slips. This information might be recovered provided that the morphology is analyzed at high resolution and " continuously " over a significant fault length. Remote lidar data are powerful to perform such analyses.
ISSN: 2169-9313

insu-01469219
https://hal-insu.archives-ouvertes.fr/insu-01469219
https://hal-insu.archives-ouvertes.fr/insu-01469219/document
https://hal-insu.archives-ouvertes.fr/insu-01469219/file/Manighetti_et_al-2015-Journalsur Geophysical_Research__Solid_Earth.pdf
DOI : 10.1002/2014JB011787

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
ISSN: 0305-7453

hal-01470808
https://hal.archives-ouvertes.fr/hal-01470808
DOI : 10.1093/jac/dkw352
PUBMED : 27609051

Éditeur(s) : HAL CCSD
Résumé : International audience
OBJECTIVE: To assess sperm production and aneuploidy in Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) before and after treatments. DESIGN: Multicenter, prospective, longitudinal study of lymphoma patients analyzed before treatment and after 3, 6, 12, and 24 months. SETTING: University hospitals. PATIENT(S): Forty-five HL and 13 NHL patients were investigated before and after treatment. Treatment regimens were classified in two groups: ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine) with or without (+/-) radiotherapy, and CHOP (doxorubicin, cyclophosphamide, vincristine, prednisone)/MOPP-ABV (mechlorethamine, oncovin, procarbazine, prednisone-doxorubicin, bleomycin, vinblastine). A control group of 29 healthy men was also studied. INTERVENTION(S): Semen analyses and aneuploidy study by FISH were performed at each time point. MAIN OUTCOME MEASURE(S): Comparison of mean sperm characteristics and percentage of sperm aneuploidy rates before and after treatment. RESULT(S): Before treatment, HL and NHL men had altered semen characteristics and higher sperm aneuploidy rates (median 0.76 [interquartile range 0.56-0.64]) than the control group (0.54 [0.46-0.74]). After treatment, sperm production was significantly lowered 3 and 6 months after ABVD +/- radiotherapy or CHOP/MOPP-ABV. After ABVD +/- radiotherapy, the aneuploidy rate increased significantly only at 3 months, and values obtained 1 or 2 years later were lower than pretreatment values. In contrast, in the CHOP/MOPP-ABV treatment group, semen characteristics and aneuploidy rate did not return to normal levels until 2 years after treatment. CONCLUSION(S): Lymphoma itself has consequences on sperm aneuploidy frequency before treatment. Moreover, lymphoma treatments have deleterious effects on sperm chromosomes related to treatment type and time since treatment. Patient counseling is essential concerning the transient but significant sperm aneuploidy induced by lymphoma and its treatments.
Fertility and sterility

hal-01477204
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01477204
DOI : 10.1016/j.fertnstert.2016.10.001
PUBMED : 27810161

Éditeur(s) : HAL CCSD Nature Publishing Group
Résumé : International audience
Collisional mountain belts grow as a consequence of continental plate convergence and eventuallydisappear under the combined effects of gravitational collapse and erosion. Using a decade ofGPS data, we show that the western Alps are currently characterized by zero horizontal velocityboundary conditions, offering the opportunity to investigate orogen evolution at the time ofcessation of plate convergence. We find no significant horizontal motion within the belt, but GPS andlevelling measurements independently show a regional pattern of uplift reaching ~2.5 mm/yr in thenorthwestern Alps. Unless a low viscosity crustal root under the northwestern Alps locally enhancesthe vertical response to surface unloading, the summed effects of isostatic responses to erosion andglaciation explain at most 60% of the observed uplift rates. Rock-uplift rates corrected from transientglacial isostatic adjustment contributions likely exceed erosion rates in the northwestern Alps. In theabsence of active convergence, the observed surface uplift must result from deep-seated processes.
ISSN: 2045-2322

hal-01357450
https://hal.archives-ouvertes.fr/hal-01357450
https://hal.archives-ouvertes.fr/hal-01357450/document
https://hal.archives-ouvertes.fr/hal-01357450/file/noquet2016.pdf
DOI : 10.1038/srep28404

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Due to their geographic location and traditional diet, rich in seafood and marine mammals, the Inuit living in Arctic Quebec are exposed to high amounts of pollutants, including organochlorine pesticides (OCPs). While the adverse developmental effects of these pesticides on child cognitive functions are well known, the effects of developmental exposure to OP on sensory processes have not been investigated. The aim of this longitudinal study was to assess the effects of prenatal and childhood exposure to 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (p,p'-DDT) and its major metabolite 1,1,-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE), on visual processing in Inuit children in Nunavik (Arctic Québec). p,p'-DDT and p,p'-DDE concentrations were determined from umbilical cord and 5- and 11-year plasma samples. Visual evoked potentials (VEPs) were successfully recorded in 150 children at 4 contrast levels (95%, 30%, 12%, and 4%). Hierarchical multiple regressions were conducted to determine the association between p,p'-DDT, or p,p'-DDE, exposure and VEPs while controlling for the effects of various confounders, including fish nutrients and other contaminants. p,p'-DDE measured in umbilical cord plasma was significantly related to the amplitude of the N150 response at the lowest contrast (4%). In addition, 5-year p,p'-DDE plasma concentration was significantly associated with decreased N75 amplitude. These findings indicate that p,p'-DDE exposure, both pre- and postnatally, during early childhood is associated with visual processing impairment later in life.
ISSN: 0161-813X

hal-01061309
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01061309
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01061309/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01061309/file/Prenatal_and_5-year-NEUTOX-D-13-00192R2_v4.pdf
DOI : 10.1016/j.neuro.2014.04.009

Éditeur(s) : HAL CCSD National Academy of Sciences
Résumé : International audience
ISSN: 0027-8424

halsde-00335837
https://hal.archives-ouvertes.fr/halsde-00335837
DOI : 10.1073/pnas.0708015105