Éditeur(s) : Man and Coastal Areas – Towards a sustainable Aquaculture, May 2000
Résumé : Fish culture (seabass, turbot...) on the French metropolitan coast, and shrimp culture in the overseas territories (essentially New Caledonia and Tahiti) are subject to a regular development through land based farms. Three thematic of research on aquaculture ponds are carried out in CREMA-L’Houmeau, in collaboration with producers. The aim of the first one is to determine the optimal rearing conditions (stocking density, water renewal rate, input of oxygen, rate of feeding...) which allow to minimise the quantity of wastes for a similar final biomass. The second part aims to reduce the nutrient loading in the effluent, through open-air treatments: sedimentation ponds, foam fractionation, mass production of phytoplankton, and rearing of molluscs on the produced phytoplankton. The third part concerns research aiming to model the “ production - treatment - valorisation ” relationships.

Droits : 2000 Ifremer
http://archimer.ifremer.fr/doc/00016/12728/9650.pdf
http://archimer.ifremer.fr/doc/00016/12728/

Résumé : La tuberculose (TB), maladie infectieuse contagieuse, est causée par une mycobactérie appartenant au complexe Mycobacterium tuberculosis (MTBC). Malgré de nombreuses campagnes de vaccination par le BCG (Bacilles de Calmette et Guérin) et les traitements antituberculeux, on observe une réémergence de la maladie depuis les années 80. Ce bouleversement s’explique par la coïnfection avec le virus du VIH/SIDA, la désorganisation des systèmes de santé et par l’apparition des bactéries résistantes aux principaux antibiotiques antituberculeux. Dans ce contexte une meilleure connaissance des mouvements et de l’évolution des clones circulants du bacille tuberculeux permettrait de détecter plus rapidement et de façon plus pertinente l’émergence d’épidémies. Le contrôle et la surveillance de la maladie représentent des moyens essentiels pour lutter contre l’expansion mondiale de la tuberculose. C’est ainsi que l’unité de la Tuberculose et des Mycobactéries de l’Institut Pasteur de la Guadeloupe (IPG) a mis en place une base de données de profils génotypiques pour l’étude de l’épidémiologie globale de la tuberculose. Dans le cadre de cette thèse, nous décrirons les méthodes de bioinformatique qui ont été utilisées pour la gestion et l’exploitation de la 6ème version (SITVIT2) de cette base de données des génotypes pour mieux comprendre l’évolution et la dissémination mondiale du bacille tuberculeux. Cette base intègre aussi plusieurs marqueurs moléculaires tels que les MIRU-VNTRs (« mycobacterial interspersed repetitive units-variable number of tandem repeats ») et le Spoligotype43 servant à mieux décrire et identifier les familles de profils génotypiques du MTBC. La banque de données SITVIT2 ne cesse d’évoluer, et elle contient actuellement des informations épidémiologiques sur 111 635 isolats cliniques. Cette base de données est consultable en ligne à l’adresse suivante : http://www.pasteur-guadeloupe.fr:8081/SITVIT2/. Nous avons également réalisé une base de données nommée SITVITBovis qui est dédiée à la tuberculose bovine. Cette base de données sera accessible à l’adresse : http://www.pasteur-guadeloupe.fr:8081/SITVIT_Bovis/. Parallèlement au développement et à la gestion des bases de données, ce travail de thèse s’est appuyé sur plusieurs études épidémiologiques et phylogéographiques mettant en corrélation les données disponibles sur la résistance aux médicaments ou les caractéristiques démographiques (dont le sexe, l’âge, le statut VIH, et l’origine du patient). Notre initiative de recherche permet ainsi d’améliorer la caractérisation phylogénétique détaillée des lignées du MTBC, ainsi que l’épidémiologie des clones en circulation, afin d’élaborer une cartographie géographique des isolats cliniques prédominants pour les bacilles tuberculeux principalement impliqués dans la maladie, à l’échelle nationale, régionale et mondiale. La superposition ultérieure de ces cartes avec des données sociopolitiques, économiques et démographiques obtenues auprès de Systèmes d’information géographique (SIG) ont permis de dresser un portrait précis des disparités actuelles par pays ou sous-région. Cette thèse représente une importante collaboration avec plusieurs équipes de chercheurs travaillant également dans le domaine de l’épidémiologie moléculaire de la tuberculose. L’objectif à long terme de ce travail, est d’optimiser la structure de la base, et de pérenniser l’enrichissement de celle-ci (notamment par l’automatisation et la facilité de la saisie de données). Une représentation optimale et une meilleure accessibilité des données de la base conforteraient les efforts faits pour le contrôle et la surveillance de la TB dans monde.
Tuberculosis (TB) is a contagious infectious disease caused by mycobacteria belonging to the Mycobacterium tuberculosis complex (MTBC). Despite numerous campaigns of vaccination by the BCG (Bacillus Calmette-Guérin) vaccine, and TB treatments, there was a resurgence of the disease since the 80s. This disruption is due to coinfection with HIV/AIDS, disorganization of health systems and the emergence of bacteria resistant to anti-TB drugs. In this context, a better understanding of the movements and changes of circulating clones of tubercle bacilli would detect faster and more relevant emerging epidemics. The control and monitoring of the disease are essential means to fight against the worldwide spread of tuberculosis. Thus the TB and Mycobacteria unit of the Pasteur Institute of Guadeloupe (IPG) has developed a database of genotypic profiles for the study of global epidemiology of tuberculosis.In this thesis, we discuss the Bioinformatical methods that have been used for the management and development of the 6th version (SITVIT2) of this database of genotypes to better understand the evolution and global dissemination of the tubercle bacillus. The database also includes several molecular markers such as MIRU-VNTRs (mycobacterial interspersed repetitive units- variable number of tandem repeats) and Spoligotype43 allowing a better description and identification of the families of genotypic profiles of Mycobacterium tuberculosis complex. SITVIT2 database is constantly evolving, and it currently contains epidemiological information on 111,635 clinical isolates. This database is available online at the following address: http://www.pasteur-guadeloupe.fr:8081/SITVIT2/. We also developed a database named "SITVITBovis", which is dedicated to bovine tuberculosis. This database will be accessible at: http://www.pasteur-guadeloupe.fr:8081/SITVIT_Bovis/.Alongside the development and management of databases, this work was based on several epidemiological and phylogeographic studies correlating data on drug resistance or demographic characteristics (including sex, age, HIV status, and the origin of the patient). Our research initiative is thus focused to further improve in depth phylogenetic characterization of MTBC lineages, as well as the epidemiological analysis of circulating clones to generate evidence-based geographical mapping of predominant clinical isolates of tubercle bacilli causing the bulk of the disease both at country and regional level. Further superposition of these maps with socio-political, economical and demographical available through Geographic Information Systems (GIS) allows to have a precise view of prevailing disparities at the level of country or sub-region. This thesis represents an important collaboration with several researchers teams also working in the field of molecular epidemiology of tuberculosis.The long-term goal of this work is to further optimize the database structure, and sustain enriching it (including automation and ease of data entry). Optimum performance and accessibility of data in the database would reinforce efforts to control and surveillance of TB in the world.

http://www.theses.fr/2014AGUY0791/document

Résumé : This report synthesizes the discussions of a workshop organized during the "Liteau II-AMP" project , a collaborative project involving scientists and MPA managers that aimed at developing diagnostic and exploratory tools for the assessment of Marine Protected Areas performance. This 2004-2006 project was funded by the Liteau program (http://www.liteau.ecologie.gouv.fr) of the French Ministry of Ecology and Sustainable Development. The workshop was organized on 30th November and 1st December at the EPHE (University of Perpignan, France). It was aimed at gathering a number of scientists and managers involved in MPA in France and in overseas French territories, in order to discuss the issue of interactions between managers and scientists in the context of MPAs. After this fruitful workshop, we felt it was useful to produce a synthesis about interactions between scientists and managers for the MPA or MPA projects present at the workshop. The topics discussed include how to interact, the degree of involvement of both sides in interactions, research versus monitoring, gaps and expectations.
Préambule : Cette synthèse s'inscrit dans le projet « Développement d'Outils Diagnostics et Exploratoires d'Aide à la Décision pour Evaluer la Performance d'Aires Marines Protégées », projet financé par le programme Lit'eau II du Ministère de l'Ecologie et du Développement Durable. L'objet de la réunion des 30 novembre et 1er décembre 2004 à l'EPHE de Perpignan était de rassembler un certain nombre de personnes impliquées dans la gestion d'Aires Marines Protégées en France et outremer, ainsi que des scientifiques concernés par la problématique des Aires Marines Protégées afin de discuter des relations et interactions entre scientifiques et gestionnaires dans ce domaine. A l'issue de cette réunion, il s'agissait d'établir un document synthétique qui ferait le point sur les interactions entre scientifiques et gestionnaires en ce qui concerne les AMP ou projets d'AMP représentés : mode de fonctionnement, degré d'implication, études plus recherche versus suivis périodiques, besoins couverts, non couverts, anticipation des évolutions en la matière. Ce document constitue une synthèse des différents éléments qui ont pu émerger des discussions de ces deux jours et des contributions -avant et après la réunion- de différents participants.

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/2005/rapport-6797.pdf
http://archimer.ifremer.fr/doc/00000/6797/

Éditeur(s) : Pêche thonière et dispositifs de concentration de poissons, Caribbean-Martinique, 15-19 Oct 1999
Résumé : Hawaii was one of the first locations to adapt the Philippine payao concept for use in high energy, deep-water environments. Initial experimental fad deployments were made by the National Marine Fisheries Service in 1977. In 1980, the State of Hawaii started deploying FADs in a programme that has since expanded to its current status of 52 approved surface fad sites. Funding is primarily derived from federal US programmes and the FADs are primarily focused on the sport fishing community. fad sites were selected to expedite access by sport fishermen; specific sites were chosen after consultation with fishermen at public hearings. Since 1997, the FAD system has been managed on a collaborative basis between the State of Hawaii and the University of Hawaii. Hawaiian FADs evolved through two previous designs before the current system of single-sphere spar-buoy was adopted. Today's FADs have an "inverse catenary" mooring system comprised of sections of floating and sinking rope attached to a "tripod" concrete block anchor system. fad sites range between 3.2 km and 46 km from shore. Mooring depths range between 200 and 3,000 metres. Average on-site longevity is 31 months; there is no correlation between longevity and depth of mooring. Windward locations have significantly shorter lifespans than leeward locations. Ten to twenty fads are replaced each year. Each FAD costs approximately us$ 7,500 to build and deploy. Hawaiian fads are heavily used by private and commercial sport fishermen and by small-scale artisanal and commercial fishermen. Commercial pole-and-line boats occasionally use the FADs to capture skipjack tuna. Hawaiian FADs will continue to be used for various types of pelagic fisheries research.

Droits : Ifremer
http://archimer.ifremer.fr/doc/00042/15280/12666.pdf
http://archimer.ifremer.fr/doc/00042/15280/

Éditeur(s) : HAL CCSD
Résumé : International audience
The INTERREG Caribbean IV program recommends the valorization and protection of the region's environmental core, through collaborative and sustainable management of resources. It uses Martinique as the test case. The French territories of Saint-Martin, Saint-Barthélemy, Guadeloupe, and Martinique, and the member states of the Organization of Eastern Caribbean States are part of a geographic continuum that can easily be identified through its similar landscapes, climates, and natural resources and also through the environmental degradation the states have to face, caused by human activity (pollution and deterioration of ecosystems and habitats), natural hazards, and climate change including sea level rise. Therefore the islands of the Lesser Antilles are faced with an important developmental and environmental challenge, which could be easily summarized as a struggle for balance.
Meteorological Technology International

ird-00742661
http://hal.ird.fr/ird-00742661
http://hal.ird.fr/ird-00742661/document
IRD : fdi:010057442

Résumé : Cet ouvrage est le fruit d’une collaboration entre l’Agence de l’Eau Artois-Picardie et le Laboratoire d’Océanologie et de Géosciences de Wimereux (LOG). Il recense les espèces marines animales et végétales introduites sur la Côte d’Opale, en région Nord - Pas-de-Calais: le but de l'ouvrage est de présenter la liste la plus exhaustive possible des espèces marines introduites. Sont présentés la biologie, l'habitat, la date d'introduction parfois estimée ou la date de première signalisation, la répartition de l'espèce dans les mers avoisinantes ainsi que les problèmes environnementaux qu'elle pose éventuellement.

Droits : 2011 Agence de l'Eau Artois Picardie, LOG
http://archimer.ifremer.fr/doc/00158/26894/25125.pdf
http://archimer.ifremer.fr/doc/00158/26894/

Éditeur(s) : HAL CCSD Ethnobotany Research and Applications
Résumé :  
We examined the limitations of parataxonomic inventories for developing management plans for woody plant resources in tropical rain forests of southwestern Amazonia. Using compilations of herbarium labels, forest personnel interviews and published species descriptions, we assessed the accuracy of common names as parataxonomic units (PUs). We identified 384 common names for 310 harvested woody plant species in the Brazilian state of Acre, of which only 50% were unique to a single taxonomic species. About 10% of common names referred to more than one species, more than half of which included multiple genera. For the 106 species from the Acre sample common to the MAP region including Madre de Dios, Peru and Pando, Bolivia, we identified 198 common names. Splitting was much more frequent in this sample, with more than 80% of species having more than one common name. When the Acre sample was expanded to 131 species from the Brazilian Amazon region, including the states of Amazonas and Para, we identified 740 common names, with nearly 90% of species being represented by more than one common name. Errors and inaccuracy of parataxonomy may contribute to market instability if product orders can not be homogenized within regional markets, and to unsustainable harvests if species are mistakenly lumped into single parataxonomic units. We discuss several programs currently being implemented by our collaborative team in the region to address this issue, including field guides based on digital photography, field courses, and workshops featuring discussions between regional inventory personnel and botanists.
Ethnobotany Research and Applications

hal-01032130
https://hal.archives-ouvertes.fr/hal-01032130

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Given a graph, its hyperbolicity is a measure of how close its distance distribution is to the one of a tree. This parameter has gained recent attention in the analysis of some graph algorithms and the classification of complex networks. We study on practical improvements for the computation of hyperbolicity in large graphs. Precisely, we investigate on relations between the hyperbolicity of a graph G and the hyperbolicity of its atoms, that are the subgraphs output by the clique-decomposition invented by Tarjan [51, 65]. We prove that the maximum hyperbolicity taken over the atoms is at most one unit off from the hyperbol-icity of G and the bound is sharp. We also give an algorithm to slightly modify the atoms, called the " substitution method " , which is at no extra cost than computing the clique-decomposition, and so that the maximum hyperbolicity taken over the resulting graphs is exactly the hyperbolicity of the input graph G. An experimental evaluation of our method for computing the hyperbolicity of a given graph from its atoms is provided for collaboration networks and biological networks. Finally, on a more theoretical side, we deduce from our results the first linear-time algorithm for computing the hyperbolicity of an outerplanar graph.
ISSN: 0304-3975

hal-01540756
https://hal.inria.fr/hal-01540756
https://hal.inria.fr/hal-01540756/document
https://hal.inria.fr/hal-01540756/file/CCDL-2017.pdf
DOI : 10.1016/j.tcs.2017.06.001

Éditeur(s) : Physiomar 08, Book of abstracts - Brest, France - 1-4 September, 2008
Résumé : This second mollusc physiology meeting has being organized jointly by LEMAR (IUEM: European Institute for Marine Studies) and LPI (Ifremer: French Institute for the Exploitation of the Sea), as both laboratories conduct research in this field. Physiomar 08 followed the very successful workshop 'Physiological aspects of reproduction and nutrition in marine mollusks' held in La Paz (Mexico) in November 2006 under the guidance of Maria Concepcion Lora Vilchis and Elena Palacios Metchenov from CIBNOR. This year's meeting has focus on Reproduction, Growth, Nutrition and Genetics and genomics of marine molluscs, and included a specific session on the effects of climate change on mollusc physiology: Global change. This conference has served as a forum for the communication of recent advances in all aspects of the physiology in molluscs. Researchers, students, stakeholders and mollusc farmers have had the opportunity to communicate personally in a friendly environment with leaders in the field. This meeting aimed to provide a vehicle for continuing exchanges, cooperation, and collaboration in the field of the physiology of marine molluscs to better understand their adaptation ability in a changing environment, their ecological significance, and to promote their sustainable culture.

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/2008/acte-4600.pdf
http://archimer.ifremer.fr/doc/00000/4600/

Éditeur(s) : HAL CCSD
Résumé : International audience
The purpose of this study is to identify links between the geothermal context and the conceptions in different initial teachers training, from the Caribbean and North America. The Caribbean Islands are located in a subduction zone, creating a great potential for geothermal energy. In Guadeloupe, this potential has been harnessed and a geothermal power plant produces about 5% of the local demand for electricity. It is called high temperature geothermy. In Quebec the bedrock mainly consists of ancient Precambrian rocks from the Canadian Shield, which does not allow for electricity production. The geothermal heat is used to regulate the temperature in buildings, to create spars, to grow crops and other purposes. It is called low temperature geothermy. This design-based research (Sandoval, W. et Al., 2004) takes part in the contextualization of sciences education research works (Blanchet, P. et Al., 2009, Anciaux, F. et Al., 2013) and in the continuation of the Gounouy project (Fecil, S. et Al., 2014). A project-based learning on geothermal energy has been set up with two groups of initial teachers training from the Université du Québec à Montréal (UQAM) and from the French West Indies University (UA). The purpose is to create collaborations between each group in order to enable them to encounter, recognize and formulate their conceptions. Further, they will collectively elaborate a more complex understanding of conceptions about geothermy. More specifically, the design used in this experiment aims to highlight context effects (Merlo-Leurette, S., Forissier, T., 2009). Context effects are pedagogical events occurring when there is a clash between the different conceptions of students, observed uring courses regarding different problematics related to geothermal energy. Communications via videoconferences were arranged so that the counterpart teams may discuss their investigative findings. Videos from the exchanges have been collected, as well as weekly summaries about student’s accomplishment, ideas, questions and feelings. Pre-test and post-test questionnaires on geothermal energy were submitted at the beginning and at the end of the project, to compare conceptions before and after the learning process. Collected data enables to bring out the student’s contextuality. Therefore, they highlight context effects, due to the differences between the geothermal contexts in Guadeloupe and in Montreal.This study is supported by the Geotref project.
CARIBBEAN ACADEMY OF SCIENCES 20 th GENERAL ASSEMBLY AND BIENNAL MEETING
Dehaies, Guadeloupe, France

hal-01534665
https://hal.univ-antilles.fr/hal-01534665

Éditeur(s) : HAL CCSD Taylor & Francis (Routledge)
Résumé : International audience
Border areas are particular “hot spots” generating high levels of HIV vulnerability and facing great challenges to control epidemics. The objective of this study is to describe the sociodemographic, clinical and biological profiles of newly HIV diagnosed people at the French Guiana - Suriname border, to construct an HIV care cascade and compare it with the Surinamese one. HIV-patients aged over 15 years newly diagnosed in western French Guiana in 2011 and 2012 were included in a retrospective cohort study. Patients were identified using different sources (n=121). The male-to-female ratio was 0.8, 85% of the patients were of foreign origin, 72% were undocumented migrants, 21% were living in Suriname and 48% had baseline CD4 cell counts <200 cells/mm3. After one year, 34% were lost to follow-up, 54% received treatment, 34% had controlled viremia and 6% died. We observed a disappointing HIV cascade, like that of Suriname, requiring to develop a coordinated healthcare offer on both sides of the border. Targeted efforts through a bi-national collaboration are needed to address the specific issues of cross-border patients to reach the 90*3 UNAIDS’s diagnosis, link to care and treatment targets and better control the local epidemic
ISSN: 0954-0121

inserm-01476267
http://www.hal.inserm.fr/inserm-01476267
http://www.hal.inserm.fr/inserm-01476267/document
http://www.hal.inserm.fr/inserm-01476267/file/2017%20Jaries%20-%20Population%20movements%20and%20the%20HIV%20cascade-1.pdf
DOI : 10.1080/09540121.2017.1291899

Éditeur(s) : HAL CCSD MDPI
Résumé : International audience
Marine micro-and macroorganisms are well known to produce metabolites with high biotechnological potential. Nearly 40 years of systematic prospecting all around the New Caledonia archipelago and several successive research programs have uncovered new chemical leads from benthic and planktonic organisms. After species identification, biological and/or pharmaceutical analyses are performed on marine organisms to assess their bioactivities. A total of 3582 genera, 1107 families and 9372 species have been surveyed and more than 350 novel molecular structures have been identified. Along with their bioactivities that hold promise for therapeutic applications, most of these molecules are also potentially useful for cosmetics and food biotechnology. This review highlights the tremendous marine diversity in New Caledonia, and offers an outline of the vast possibilities for natural products, especially in the interest of pursuing collaborative fundamental research programs and developing local biotechnology programs.
EISSN: 1660-3397

Droits : http://creativecommons.org/licenses/by/
hal-01292225
http://hal.upmc.fr/hal-01292225
http://hal.upmc.fr/hal-01292225/document
http://hal.upmc.fr/hal-01292225/file/marinedrugs-14-00058.pdf
DOI : 10.3390/md14030058

Éditeur(s) : HAL CCSD
Résumé : La gouvernance informationnelle de l'environnement en Guyane : état des lieux et perspectives de collaboration, Cayenne, 8-9 septembre 2016
https://hal-agroparistech.archives-ouvertes.fr/hal-01503812

hal-01503812
https://hal-agroparistech.archives-ouvertes.fr/hal-01503812

Éditeur(s) : HAL CCSD
Résumé : International audience
The active selection of recent volcanic habitats by juvenile fish following a cyclone could explain the unusual mass-settlement of the Indian Ocean blacktip grouper Epinephelus oceanicus observed on 25 May 2006, few weeks after tropical storm Diwa on the latest lava flows of the Piton de la Fournaise volcano at Reunion Island. Following a cyclonic depression, shallow underwater habitats are devoid of resident fishes, including predators, favouring juvenile fish survival. Otherwise, the recent origin of the volcanic habitats, which vary in age, could facilitate the spatial segregation of adult and juvenile fish on the lava flows, reducing intraspecific competition and adult aggression toward juveniles. Regional characteristics of larval recruitment could also contribute to the infrequency of the described event; the isolated situation of the island would be expected to result in an average density of fish postlarvae 0.25 % to 1 % of that seen on some reefs in the Pacific. The supposed origin of juvenile groupers in the neighbouring island of Mauritius should encourage Reunionese managers to look beyond their own jurisdictions to adopt a collaborative approach to conservation of the entire connected network.
Environmental Biology of Fishes

hal-01306707
http://hal.univ-reunion.fr/hal-01306707
http://hal.univ-reunion.fr/hal-01306707/document
http://hal.univ-reunion.fr/hal-01306707/file/Mass-settlement%20of%20the%20Indian%20ocean%20black-tip%20grouper_hal.pdf
DOI : 10.1007/s10641-014-0303-2

Éditeur(s) : HAL CCSD
Résumé : Food-grade dairy propionibacteria are nutraceutical producers. They release short chain fatty acids (SCFAs), folic acid and cobalamin, which play a role in intestinal physiology. SCFAs induce apoptosis via the mitochondrial death pathway. We investigated the potential of dairy propionibacteria-fermented products to synergize with drugs used in gastric and colorectal cancer.Fermented milk contained high and viable populations of propionibacteria. This product, as well as its cell-free supernatant, were tested in vitro on gastric HGT-1 and colic HT-29 cells with respect to apoptosis and synergy with known anti-cancer molecules, camptothecin and the human cytokine TRAIL (TNF Related Apoptosis Inducing Ligand). Viability was monitored and apoptosis quantified by Hoescht staining, ROS production, mitochondrial membrane potential perturbation and caspases activity assay. A transcriptomic study on genome-wide microarray was performed in collaboration with the company Miltenyi.Fermented milk induced cell death in both gastric and colon cancer cells. Characterization of cells revealed cell cycle arrest, drop in intracellular ATP, depolarization of mitochondria, translocation of key apoptosis proteins, processing of caspases and fragmentation of the nucleus. Interestingly, the fermented milk was shown to potentiate the cytotoxic effect of molecules used in cancer chemotherapy, camptothecin and TRAIL. The observed synergistic pro-apoptotic effect between TRAIL and propionibacterial SCFAs depended on death receptors and on caspases, was more lethal on cancer cells than on normal human intestinal epithelial cells (HIEC), and was inhibited by Bcl-2 expression. Transcriptomics revealed that propionibacterial metabolites boosted TRAIL-induced modulation of gene expression in human colon cancer cells.These results open new perspectives in the field of colon cancer cells prevention and/or treatment. The synergy with pro-apoptotic chemotherapy molecules suggests that such a fermented product, or the propionibacterium alone, may be proposed as a food supplement to enhance the effects of anticancer treatments.
The 2nd International conference on Cell Death In Cancer (CDIC)
La Baule, France

hal-01209622
https://hal.archives-ouvertes.fr/hal-01209622
PRODINRA : 261291

Éditeur(s) : HAL CCSD American College of Physicians
Résumé : International audience
BACKGROUND: Most clinical guidelines recommend that AIDS-free, HIV-infected persons with CD4 cell counts below 0.350 × 10(9) cells/L initiate combined antiretroviral therapy (cART), but the optimal CD4 cell count at which cART should be initiated remains a matter of debate. OBJECTIVE: To identify the optimal CD4 cell count at which cART should be initiated. DESIGN: Prospective observational data from the HIV-CAUSAL Collaboration and dynamic marginal structural models were used to compare cART initiation strategies for CD4 thresholds between 0.200 and 0.500 × 10(9) cells/L. SETTING: HIV clinics in Europe and the Veterans Health Administration system in the United States. PATIENTS: 20, 971 HIV-infected, therapy-naive persons with baseline CD4 cell counts at or above 0.500 × 10(9) cells/L and no previous AIDS-defining illnesses, of whom 8392 had a CD4 cell count that decreased into the range of 0.200 to 0.499 × 10(9) cells/L and were included in the analysis. MEASUREMENTS: Hazard ratios and survival proportions for all-cause mortality and a combined end point of AIDS-defining illness or death. RESULTS: Compared with initiating cART at the CD4 cell count threshold of 0.500 × 10(9) cells/L, the mortality hazard ratio was 1.01 (95% CI, 0.84 to 1.22) for the 0.350 threshold and 1.20 (CI, 0.97 to 1.48) for the 0.200 threshold. The corresponding hazard ratios were 1.38 (CI, 1.23 to 1.56) and 1.90 (CI, 1.67 to 2.15), respectively, for the combined end point of AIDS-defining illness or death. Limitations: CD4 cell count at cART initiation was not randomized. Residual confounding may exist. CONCLUSION: Initiation of cART at a threshold CD4 count of 0.500 × 10(9) cells/L increases AIDS-free survival. However, mortality did not vary substantially with the use of CD4 thresholds between 0.300 and 0.500 × 10(9) cells/L.
ISSN: 0003-4819

hal-00875307
https://hal.archives-ouvertes.fr/hal-00875307
PUBMED : 21502648
DOI : 10.7326/0003-4819-154-8-201104190-00001

Éditeur(s) : HAL CCSD Ecole nationale du génie rural
Résumé :  
La conservation des ressources génétiques forestières garantit le maintien d'une diversité élevée, donc l'adaptation des espèces forestières tropicales aux conditions écologiques actuelles et futures. Elle nécessite d'élaborer des stratégies appropriées à l'aménagement des forêts et, pour cela, d'appréhender tout d'abord le niveau et la structure de la diversité génétique, de comprendre et prévoir ensuite sa dynamique. C'est dans cet esprit qu'une collaboration a été entreprise entre la Guyane française et le Brésil, malgré les différences existant entre les deux systèmes de gestion. À partir de résultats sur les parcelles expérimentales de Paracou (Guyane) et Tapajós (Brésil), un ensemble intégré d'outils a été élaboré, allant d'une base de données et d'utilitaires cartographiques jusqu'à un modèle de simulation de la dynamique des structures génétiques et à un logiciel de gestion.
ISSN: 0035-2829

hal-01032246
https://hal.archives-ouvertes.fr/hal-01032246

Éditeur(s) : ICES 2008 Annual Science Conference, 22-26 september 2008, HALIFAX, CANADA
Résumé : Since 2000, Ifremer has been implemented a Fisheries Information System (FIS), in strong collaboration with the DPMA (Direction of fisheries and aquaculture of the French Ministry of Agriculture and Fisheries). The FIS aims at building an operational and multidisciplinary monitoring network for scientific purposes, allowing a comprehensive view of fishery systems including their biological, technical, environmental and economical components. The objectives of the FIS are (i) to provide the specifications and methodologies for the collection, storage and processing of fisheries data, with the constant concern to harmonise all these procedures on a national scale, (ii) to improve data management system and access to data for a wide-spread public, and (iii) to produce and distribute relevant datasets, indicators and synthesis, for understanding and evaluation, including bio-economic diagnostics of the fisheries, and assessment of the short and long-term impacts of fisheries management scenario and measures. The FIS covers all the French fisheries, including overseas territories and small-scale fisheries, for which data are often hardly available or missing, whereas two thirds of the French vessels are less than 12 meters long. The challenge was to establish a statistical and an integrated approach supporting bio-ecological and economic issues. To further an integrated analysis of the fishery systems, the wide range kinds of data - including acoustic surveys, biological in-situ observations, environmental observations, as well as fishing statistics (landings and efforts) or economic data - are managed in a single data management system, based on an integrated relational data base with geographical facilities.

Droits : 2008 ICES
http://archimer.ifremer.fr/doc/00059/17002/14504.pdf
http://archimer.ifremer.fr/doc/00059/17002/

Éditeur(s) : HAL CCSD Endocrine Society
Résumé : International audience
The Developmental Origins of Health and Disease (DOHaD) paradigm is one of the most rapidly expanding areas of biomedical research. Environmental stressors that can impact on DOHaD encompass a variety of environmental and occupational hazards as well as deficiency and oversupply of nutrients and energy. They can disrupt early developmental processes and lead to increased susceptibility to disease/dysfunctions later in life. Presentations at the fourth Conference on Prenatal Programming and Toxicity in Boston, in October 2014, provided important insights and led to new recommendations for research and public health action. The conference highlighted vulnerable exposure windows that can occur as early as the preconception period and epigenetics as a major mechanism than can lead to disadvantageous "reprogramming" of the genome, thereby potentially resulting in transgenerational effects. Stem cells can also be targets of environmental stressors, thus paving another way for effects that may last a lifetime. Current testing paradigms do not allow proper characterization of risk factors and their interactions. Thus, relevant exposure levels and combinations for testing must be identified from human exposure situations and outcome assessments. Testing of potential underpinning mechanisms and biomarker development require laboratory animal models and in vitro approaches. Only few large-scale birth cohorts exist, and collaboration between birth cohorts on a global scale should be facilitated. DOHaD-based research has a crucial role in establishing factors leading to detrimental outcomes and developing early preventative/remediation strategies to combat these risks
ISSN: 0013-7227

hal-01187409
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01187409
DOI : 10.1210/EN.2015-1350
PUBMED : 26241067

Éditeur(s) : HAL CCSD CERAMAC
Résumé : International audience
Nous présentons les résultats de la mise en œuvre du " jeu de territoire " réalisé par des élèves-ingénieurs dans le cadre de la révision du plan stratégique menée par les acteurs du Témiscamingue (Québec, Canada). Trois phases de réflexion et d'argumentation favorisant une élaboration collaborative : la constitution d'un portait du territoire et d'un diagnostic des enjeux, l'élaboration de scénarios d'évolution prospective à 15 ans et l'énoncé de premières pistes d'orientation pour le prochain plan stratégique. Nous discutons les apports du jeu comme dispositif d'apprentissage collectif pour la mobilisation et le partage des connaissances et comme dispositif de production iconographique pour la construction de représentations partagées et leur appropriation collective. Nous mettons en évidence l'intérêt d'une hybridation des compétences et des savoirs, entre recherche, formation et action, pour faciliter la mobilisation des acteurs dans les démarches participatives de conception de projets de territoire.
Développement durable des territoires : de la mobilisation des acteurs aux démarches participatives
Clermont-Ferrand, France

hal-00982919
https://hal-agroparistech.archives-ouvertes.fr/hal-00982919