Éditeur(s) : Paris : chez Pillet aîné
Siècle(s) traité(s) : 19
Droits : Domaine public
Provenance : Collectivité territoriale de Martinique. Bibliothèque Schoelcher
Permalien : http://www.manioc.org/patrimon/SCH13173
SCH13173

Extrait de : Écho des Mines et de la métallurgie Février 19523
Résumé : Article 20 p., 1 tiré à part
Siècle(s) traité(s) : 20
Droits : Domaine public
Provenance : ORkidé|Fonds privé Pierre Rostan
Permalien : http://www.manioc.org/patrimon/ORK12173
ORK12173

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Macrophages (MΦ), well-known to play an important role in immune response, also respond to environmental toxic chemicals such as diesel exhaust particles (DEP). Potential effects of DEPs towards MΦ polarization, a key hall-mark of MΦ physiology, remain however poorly documented. This study was therefore designed to evaluate the effects of a reference DEP extract (DEPe) on human MΦ polarization. Human blood monocytes-derived MΦ were incubated with IFNγ+LPS or IL-4 to obtain M1 and M2 subtypes, respectively; a 24 h exposure of polarizing MΦ to 10 μg/ml DEPe was found to impair expression of some macrophagic M1 and M2 markers, without however overall inhibition of M1 and M2 polarization processes. Notably, DEPe treatment increased the secretion of the M1 marker IL-8 and the M2 marker IL-10 in both MΦ subtypes, whereas it reduced lipopolysaccharide-induced IL-6 and IL-12p40 secretion in M1 MΦ. In M2 MΦ, DEPe exposure led to a reduction of CD200R expression and of CCL17, CCL18 and CCL22 secretion, associated with a lower chemotaxis of CCR4-positive cells. DEPe activated the Nrf2 and AhR pathways and induced expression of their reference target genes such as Hmox-1 and cytochrome P-4501B1 in M1 and M2 MΦ. Nrf2 or AhR silencing through RNA interference prevented DEPe-related down-regulation of IL-6. AhR silencing also inhibited the down-secretion of IL-12p40 and CCL18 in M1- and M2-DEPe-exposed MΦ, respectively. DEPs are therefore likely to alter expression of some M1 and M2 markers in an AhR- and Nrf2-dependent manner; such regulations may contribute to deleterious immune effects of atmospheric DEP.
ISSN: 1932-6203

hal-01122723
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01122723
PUBMED : 25710172
DOI : 10.1371/journal.pone.0116560

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
Hepatocellular carcinoma treatment by arterial infusion of cis-diamminedichloroplatinum-II (cisplatin) exhibits certain therapeutic efficacy. However, optimizations are required and the mechanisms underlying cisplatin proapoptotic effect remain unclear. The mitogen-activated protein kinase (MAPK) pathway plays a key role in cell response to cisplatin and the functional specificity of the isoform MAPK/ERK kinase 1 and 2 (MEK1/2) and ERK1/2 could influence this response. The individual contribution of each kinase on cisplatin-induced death was thus analyzed after a transient or stable specific inhibition by RNA interference in the human hepatocellular carcinoma cells Huh-7 or in knockout mice. We demonstrated here that ERK1 played a predominant role over ERK2 in cisplatin-induced death, whereas MEK1 and MEK2 acted in a redundant manner. Indeed, at clinically relevant concentrations of cisplatin, ERK1 silencing alone was sufficient to protect cells from cisplatin-induced death both in vitro, in Huh-7 cells and ERK1(-/-) hepatocytes, and in vivo, in ERK1-deficient mice. Moreover, we showed that ERK1 activity correlated with the induction level of the proapoptotic BH3-only protein Noxa, a critical mediator of cisplatin toxicity. On the contrary, ERK2 inhibition upregulated ERK1 activity, favored Noxa induction and sensitized hepatocarcinoma cells to cisplatin. Our results point to a crucial role of ERK1 in cisplatin-induced proapoptotic signal and lead us to propose that ERK2-specific targeting could improve the efficacy of cisplatin therapy by increasing ERK1 prodeath functions.
ISSN: 0143-3334

inserm-00814096
http://www.hal.inserm.fr/inserm-00814096
DOI : 10.1093/carcin/bgs317
PUBMED : 23042098

Éditeur(s) : Paris : Plon-Nourrit
Résumé : 3e édition revue et augmentée
Siècle(s) traité(s) : 20
Droits : Domaine public
Provenance : Collectivité territoriale de Guyane. Bibliothèque Alexandre-Franconie
Permalien : http://www.manioc.org/patrimon/FRA12063
FRA12063

Éditeur(s) : Gauthier-Villars
Résumé : The benthic macroinvertebrate assemblages of the Argentine continental shelf were studied from samples of molluscs, echinoderms and bryozoans collected by the RN Shinkai Maru. Two major faunal groups were distinguished: one inhabiting the warmer inner shelf off Buenos Aires and northern Patagonia, and the other occupying the colder middle and outer shelf off Buenos Aires and most of the Patagonian shelf. These results confirm the traditional biogeographic division of the Argentine continental shelf into two provinces: Argentine and Magellanic. Furthermore, the results suggest the possibility of subdividing the Atlantic sector of the Magellanic province into two districts: Patagonian and Malvinean, under the influence of the Patagonian and the Malvinas current, respectively.
Oceanologica Acta (0399-1784) (Gauthier-Villars), 1992 , Vol. 15 , N. 6 , P. 687-698

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/00101/21234/18851.pdf
http://archimer.ifremer.fr/doc/00101/21234/

Éditeur(s) : HAL CCSD Society for the Study of Reproduction
Résumé : International audience
ISSN: 0006-3363

hal-01122125
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01122125
PUBMED : 25609838
DOI : 10.1095/biolreprod.114.126250

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : International audience
Antisynthetase syndrome is an inflammatory myopathy frequently associated with pulmonary manifestations, especially interstitial lung diseases, and uncommonly pulmonary hypertension. In the context of a suggestive clinical and radiological picture, positive anti-RNA synthetase antibodies confirm the diagnosis. Anti-Jo1, anti-PL7, and anti-PL12 antibodies are the more commonly encountered. The presence of a number of extra-thoracic manifestations in association with pulmonary disease may suggest the diagnosis. These include: myalgia or muscular deficit, Raynaud's phenomenon, polyarthritis, fever, mechanics hands. Serum creatine kinase levels are usually increased. Electromyogram, muscular magnetic resonance imaging or muscle pathology are not mandatory to make the diagnosis. There is a high variability in symptoms and severity, between patients but also during the course of the disease in the same patient. The presence of an interstitial lung disease is a major prognostic factor and an indication for more intensive treatment, principally with systemic corticosteroids with or without immunosuppressive drugs. Improving respiratory physicians’ knowledge of this disease, which is often revealed by its pulmonary manifestations, should help diagnosis, therapeutic management, and possibly prognosis.
Le syndrome des antisynthétases correspond à une myopathie inflammatoire fréquemment associée à une atteinte pulmonaire, surtout parenchymateuse (pneumopathie infiltrante diffuse) et plus rarement vasculaire (hypertension pulmonaire). Devant un tableau clinique et radiologique évocateur, la présence d’anticorps anti-ARNt synthétases signe le diagnostic. Les plus fréquents de ces auto-anticorps sont les anti-Jo1, les anti-PL7 et les anti-PL12. De nombreuses manifestations cliniques extrathoraciques associées à l’atteinte pulmonaire peuvent orienter le diagnostic : myalgies ou déficit musculaire, phénomène de Raynaud, polyarthrite, fièvre et « mains de mécaniciens ». Une augmentation des créatine-phospho-kinases est quasi constante. Le recours à l’électromyogramme, à l’imagerie musculaire par résonance magnétique ou à l’histologie n’est pas systématique. Néanmoins, il existe une grande variabilité des symptômes et de leur sévérité d’un patient à l’autre ou au long de l’évolution de la maladie. L’atteinte pulmonaire est un facteur pronostic majeur et incite à traiter de manière intensive les patients, principalement par corticothérapie systémique, voire d’emblée par association corticoïdes et immunosuppresseurs. Mieux connaître cette pathologie qui est souvent de révélation pneumologique permettrait d’améliorer le diagnostic et la prise en charge thérapeutique, voire même le pronostic.
ISSN: 0761-8425

hal-01085369
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01085369
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01085369/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01085369/file/Manifestations%20pulmonaires%20du%20syndrome%20des%20antisynth%C3%A9tases_accepted.pdf
DOI : 10.1016/j.rmr.2014.07.013

Éditeur(s) : Paris : Imprimerie nationale
Siècle(s) traité(s) : 18
Droits : Domaine public
Provenance : Communauté d'agglomération de La Rochelle. Médiathèque Michel-Crépeau
Permalien : http://www.manioc.org/patrimon/MMC16112-22
MMC16112-22

Éditeur(s) : HAL CCSD
Résumé : Diffusion du document : INRA Documentation de Centre, Domaine de Duclos, 97170 Petitt-Bourg (Guadeloupe, France) Diplôme : DEA
il s'agit d'un type de produit dont les métadonnées ne correspondent pas aux métadonnées attendues dans les autres types de produit : DISSERTATION
Because soil respiration representes 80% of ecosystem respiration, it is a major flux between biosphere and atmosphere. We examined the effects of root and litter exclusion on soil CO! efflux (Rsu1) using trenching and litter exclusion in a tropical plantation constituted of trees seedlings installed in 16 mono-specific stands 20 years ago near Kourou, French Guyana. Soil CO2 efflux was measured using an infra red gas analyser (PP System,EGM4 ) at 16 randomly distributed plot in each treatment: control, root exclusion, litter exclusion and both root and litter exclusion. in the plantation. We measured R'1l1during four periods, and we have collected soil samples, litter biomass and measured moisture at 5 cm depth in the soil. Soil CO, efflux varied significantly among species from 2,8±O,7f1mo l. m''. s' (mean ± standard deviation) to 7.4± 1.7fLmol. n'-' . s ' for Qualea rosea and Vochys ia tomentosa, respectively. 1'0 significant correlation was found between RSIlI variability and soil moisture, which is mostly related to soil texture in the experimental site. Soil CO2 efflux was significantly reduced in litter exclusion treatment and root exclusion plots (6 months litter and/or root exclusion) during ail measurements period and for ail species, compared to control plots. The reduction of soil CO, efflux was higher in plot without root than in plot without litter of control plot (42% and 25%, respectively). There was an import ant specific diversity in these reductions . We estimated the contribution of roof respiration (Rr) to total Rso1 by calculating the difference between Rso1 control and Rsn l root exclusion plot corrected for the decomposition of root that were killed following t re n e h in ~. Thus the heterotrophic component of soil carbon efflux accounts for 46% of total carbon efflux (1,9f1 mol. rn" . s•') while root respiration accounts for 54% of soil carbon release (2,3 ~t mo l. m-2 S-I) . Because there was a negative and significant correlation between microbial respiration (Rrn) and C/N of mature leaves it seemed to be possible to predict Rm if we known the mature leaves quality. In addition a good estimate theorical R ~, values from R~, measured in different treatments.
La respiration du sol en représentant une part de 80% de la respiration de l'écosystème apparaît être un flux majeur entre la biosphère et l'atmosphère. Nous avons étudié les effets de l'exclusion racinaire et de la litière sur le flux de CO, du sol (R ~ , ) en utilisant la méthode de " Trench-plots" et de suppression de litière dans une plantation d'arbres tropicaux. Ces arbres, âgés de 20 ans ont été plantés sur un sol uniforme, près de Kourou en Guyane française, en 16 placeaux mono-spécifiques. Pour mesurer les flux de CO2 provenant du sol, nous avons utilisé un analyseur différentiel de gaz infrarouge portable muni d'une chambre. Les mesures ont été faites sur 4 traitements différents tels que : le contrôle, l'exclusion racinaire, l'exclusion de litière et l'exclusion de litière et de racine et ce, répétés sur chacune des 16 placettes mono-spécifiques. Cette étude comporte 4 campagnes de mesures. Nous avons également effectué des prélèvements de sol de litière et nous avons fait des mesures d’humidité de sol à une profondeur de 5 cm. Les flux de C01 du sol varient fortement entre espèces de 2.8±O.7 ~t m o 1. m-2. sol à 7 A± 1. 7 ~t m o l. m•1 sol pour Qua/ev rosea ct Vochysto tomentasa, respectivement. Il n'existe pas de corrélation significative entre les variations de Rw l ct celles de l'humidité du sol (indication sur la texture du sol de la plantation ). Nous avons observé que Rso1 était significativement plus faible dans les placeaux sans racines et/ou sans litière (6 mois après la mise en place de l'expérimentation) pour toutes les campagnes de mesures et pour toutes les espèces que dans les placeaux contrôlés. Cette réduction du flux de CO2 du sol est plus forte dans les "trench-plots " que dans les traitement s d'exclusion de litière avec 42 et 25% respectivement. Un effet "traitement " et un effet "espèce" important expliquent 3 1"/.. ct 13% de la variabilité totale de R~. Nous avons cherché à connaître la contribution des racines dans les valeurs de R""I. en comparant le flux de CO2 provenant du sol sur des "trench -plot s'' au flux de COl provenant du sol dans les placeaux contrôlés . Cette estimation a été corrigée pour prendre en compte la décomposition des racines tuées par les tranchées. Ainsi, la composante appartenant aux micro -organismes représente 46% du flux total de carbone provenant du sol (1.9Jlmo l. m-2 S•I ) alors que la respiration des racines représente 54% du dégagement de carbone (2 ,3~lmol. m ol . 5-La respiration des micro-organismes pourrait être estimée en mesurant le C/N des feuilles matures puisqu'il existe une corrélation significative et négative entre les deux. Enfin les résultats obtenus sur les différents traitements permettent d'obtenir une bonne estimation de la respiration du sol avec un RSIlI théorique corrélé à 66% avec les valeurs réelles mesurées.
https://hal.archives-ouvertes.fr/hal-01189239

hal-01189239
https://hal.archives-ouvertes.fr/hal-01189239
PRODINRA : 18212

Éditeur(s) : Paris : Baudinière
Siècle(s) traité(s) : 20
Droits : Domaine public
Provenance : Collectivité territoriale de Guyane. Bibliothèque Alexandre-Franconie
Permalien : http://www.manioc.org/patrimon/FRA12233
FRA12233

Éditeur(s) : Genève : chez Jean-Leonard Pellet

Droits : Domaine public
Provenance : Université de Nantes. Service commun de la documentation
Permalien : http://www.manioc.org/patrimon/NAN13054-1
NAN13054-1

Éditeur(s) : Paris : Panckouke
Extrait de : Histoire de l'Amérique
Siècle(s) traité(s) : 16
Droits : Domaine public
Provenance : Ville de Pointe-à-Pitre. Réseau des bibliothèques
Permalien : http://www.manioc.org/patrimon/PAP11075
PAP11075

Éditeur(s) : Paris : Firmin Didot Frères

Droits : Domaine public
Provenance : Archives territoriales de Guyane
Permalien : http://www.manioc.org/patrimon/GAD12001
GAD12001

Droits : 1998 Ifremer, Ministère de l'Aménagement du Territoire et de l'Environnement
http://archimer.ifremer.fr/doc/00314/42561/41932.pdf
http://archimer.ifremer.fr/doc/00314/42561/

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, has emerged as an active mediator in many essential functions in the central nervous system of mammals. BDNF plays significant roles in neurogenesis, neuronal maturation and/or synaptic plasticity and is involved in cognitive functions such as learning and memory. Despite the vast literature present in mammals, studies devoted to BDNF in the brain of other animal models are scarse. Zebrafish is a teleost fish widely known for developmental genetic studies and is emerging as model for translational neuroscience research. In addition, its brain shows many sites of adult neurogenesis allowing higher regenerative properties after traumatic injuries. To add further knowledge on neurotrophic factors in vertebrate brain models, we decided to determine the distribution of bdnf mRNAs in the larval and adult zebrafish brain and to characterize the phenotype of cells expressing bdnf mRNAs by means of double staining studies. Our results showed that bdnf mRNAs were widely expressed in the brain of 7 days old larvae and throughout the whole brain of mature female and male zebrafish. In adults, bdnf mRNAs were mainly observed in the dorsal telencephalon, preoptic area, dorsal thalamus, posterior tuberculum, hypothalamus, synencephalon, optic tectum and medulla oblongata. By combining immunohistochemistry with in situ hybridization, we showed that bdnf mRNAs were never expressed by radial glial cells or proliferating cells. By contrast, bdnf transcripts were expressed in cells with neuronal phenotype in all brain regions investigated. Our results provide the first demonstration that the brain of zebrafish expresses bdnf mRNAs in neurons and open new fields of research on the role of the BDNF factor in brain mechanisms in normal and brain repairs situations.
ISSN: 1932-6203

hal-01359562
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01359562
DOI : 10.1371/journal.pone.0158057
PUBMED : 27336917

Éditeur(s) : HAL CCSD Nature Publishing Group
Résumé : International audience
The regulatory mechanisms involved in the acquisition of thermal tolerance are unknown in insects. Reversible phosphorylation is a widespread post-translational modification that can rapidly alter proteins function(s). Here, we conducted a large-scale comparative screening of phosphorylation networks in adult Drosophila flies that were cold-acclimated versus control. Using a modified SIMAC method followed by a multiple MS analysis strategy, we identified a large collection of phosphopeptides (about 1600) and phosphoproteins (about 500) in both groups, with good enrichment efficacy (80%). The saturation curves from the four biological replicates revealed that the phosphoproteome was rather well covered under our experimental conditions. Acclimation evoked a strong phosphoproteomic signal characterized by large sets of unique and differential phosphoproteins. These were involved in several major GO superclusters of which cytoskeleton organization, positive regulation of transport, cell cycle, and RNA processing were particularly enriched. Data suggest that phosphoproteomic changes in response to acclimation were mainly localized within cytoskeletal network, and particularly within microtubule associated complexes. This study opens up novel research avenues for exploring the complex regulatory networks that lead to acquired thermal tolerance.
ISSN: 2045-2322

hal-01532256
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01532256
DOI : 10.1038/s41598-017-01974-z
PUBMED : 28490779

Éditeur(s) : Para : Typographia de Santos & Menor
Siècle(s) traité(s) : 19
Droits : Domaine public
Provenance : Collectivité territoriale de Guyane. Bibliothèque Alexandre-Franconie
Permalien : http://www.manioc.org/patrimon/FRA11209
FRA11209

Éditeur(s) : Paris : Imprimerie nationale
Résumé : An V-VII : 22 sept. 1797 - 22 sept. 1799
Siècle(s) traité(s) : 18
Droits : Domaine public
Provenance : Communauté d'agglomération de La Rochelle. Médiathèque Michel-Crépeau
Permalien : http://www.manioc.org/patrimon/MMC16051-2
MMC16051-2

Éditeur(s) : Basse-terre : Imp. Du Roi
Siècle(s) traité(s) : 19
Provenance : Archives départementales de Guadeloupe
Permalien : http://www.manioc.org/patrimon/ADG18146
ADG18146