Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
Background: Neonatal infection constitutes one of Senegal’s most important public health problems, with amortality rate of 41 deaths per 1,000 live births.Methods: Between January 2007 and March 2008, 242 neonates with suspected infection were recruited at threeneonatal intensive care units in three major tertiary care centers in Dakar, the capital of Senegal. Neonatal infections wereconfirmed by positive bacterial blood or cerebrospinal fluid culture. The microbiological pattern of neonatal infectionsand the antibiotic susceptibility of the isolates were characterized. In addition, the genetic basis for antibiotic resistanceand the genetic background of third-generation cephalosporin-resistant (3GC-R) Enterobacteriaceae were studied.Results: A bacteriological infection was confirmed in 36.4 % (88/242) of neonates: 22.7 % (30/132) during the early-onsetand 52.7 % (58/110) during the late-onset periods (p > 0.20). Group B streptococci accounted for 6.8 % of the 88 collectedbacterial isolates, while most of them were Enterobacteriaceae (n = 69, 78.4 %). Of these, 55/69 (79.7 %) were 3GC-R. TheblaCTX-M-15 allele, the blaSHV and the blaTEM were highly prevalent (63.5, 65.4 and 53.8 %, respectively), usually associatedwith qnr genes (65.4 %). Clonally related strains of 3GC-R Klebsiella pneumoniae and 3GC-R Enterobacter cloacae, the twomost commonly recovered 3GC-R Enterobacteriaceae (48/55), were detected at the three hospitals, underlining the roleof cross-transmission in their spread. The overall case fatality rate was 18.6 %.Conclusions:Measures should be taken to prevent nosocomial infections and the selection of resistant bacteria
ISSN: 1471-2334

Droits : http://creativecommons.org/licenses/by/
hal-01473613
https://hal.archives-ouvertes.fr/hal-01473613
https://hal.archives-ouvertes.fr/hal-01473613/document
https://hal.archives-ouvertes.fr/hal-01473613/file/High%20third-generation%20cephalosporin%20resistant%20Enterobacteriaceae%20prevalence%20rate%20among%20neonatal%20infections%20in%20Dakar%2C%20Senegal.pdf
DOI : 10.1186/s12879-016-1935-y

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
ISSN: 1935-2727

inserm-00919502
http://www.hal.inserm.fr/inserm-00919502
http://www.hal.inserm.fr/inserm-00919502/document
http://www.hal.inserm.fr/inserm-00919502/file/2013_Nacher_-_Disseminated_histo_in_hiv_in_south_america_a_neglected_killer_continues_on_its_rampage.pdf
DOI : 10.1371/journal.pntd.0002319

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
BACKGROUND: In the context of recent guidelines on invasive candidiasis (IC), how French intensive care units (ICUs) are managing IC? METHODS: This is a prospective observational multicenter cohort study. During 1 year (2012-2013), 87 French ICUs enrolled consecutive patients with suspected or proven IC (SIC or PIC) and receiving systemic antifungal therapy (SAT). Data were collected up to 28 days after inclusion. RESULTS: We studied 835 patients, 291 with PIC and 544 with SIC. At SAT initiation, patients with SIC were significantly more severe (SAPS II 50.1 ± 18.7 vs. 46.2 ± 18.0). Severe sepsis or septic shock prompted to initiate empiric SAT in 70 % of SIC. Within 4 days in median, the initial SAT was modified in 49 % of patients with PIC vs. 33 % patients with SIC. Modifications were most often motivated by mycological results, and de-escalation was the most frequent change. Regarding compliance to IC management guidelines, echinocandin was used for 182 (62.5 %) patients with PIC, and 287 (52.7 %) of those with SIC; central venous catheter was removed in 87 (54.3 %) of patients with candidaemia, and 43 of the remaining patients received echinocandin; and de-escalation was undertaken after 5 days of SAT in 142 patients, after 10 days in 13 patients. As 20.6 % of SIC were secondarily documented, 403/835 (48 %) patients had finally a proven IC. Candida albicans was the main pathogen (65.3 %), then Candida glabrata (15.9 %). The 28-day mortality rates were 40.0 % in candidaemia, 25.4 % in cIAI, and 26.7 % in deep-seated candidiasis. In the overall population of patients with proven IC, four independent prognostic factors were identified: immunosuppression (Odds Ratio (OR) = 1.977: 1.03-3.794 95 % confidence interval (CI), p = 0.04), age (OR = 1.035; 1.017-1.053 95 % CI; p  extless 0.001), SAPS extgreater46 on ICU admission (OR = 2.894; 1.81-4.626 95 % CI; p  extless 0.001), and surgery just before or during ICU stay (OR = 0.473; 0.29-0.77 95 % CI; p  extless 0.001). CONCLUSION: When SAT is initiated in French ICUs, the IC is ultimately proven for 48 % of patients. Empiric SAT is initiated in severely ill ICU patients. The initial SAT is often adapted, with de-escalation to fluconazole when possible. Mortality rate remains high
ISSN: 2110-5820

hal-01259216
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01259216
DOI : 10.1186/s13613-015-0103-7
PUBMED : 26743881

Éditeur(s) : HAL CCSD
Résumé : International audience
Understand the dynamics of the fresh-salt water interface in aquifers is a key issue to comprehend mixing processand to quantity the discharge of nutrients in to coastal areas. In order to go beyond the current knowledge inthis issue an experimental site has been set up at the alluvial aquifer Riera Argentona (Barcelona – Spain). Thesite comprises 16 shallow piezometers installed between 30 and 90 m from the seashore, with depths rangingbetween 15 and 25 meters. The seawater interface is being monitored using several techniques, the combinationof which will help us to understand the spatial and temporal behaviour of the mixing zone and the geochemicalprocesses occurring there. Specially the deepest piezometers are equipped with electrodes in order to performcross-hole electrical resistivity tomography (CHERT). In addition, all piezometers are also equipped with FiberOptic cable to perform distributed temperature measurements. Two single steel armoured fibre optic cable lines ofaround 600m length were installed in all boreholes. The objective is to use the cable both as passive and activetemperature sensor. The first is being done for the continuous monitoring of temperature whereas; the secondprovides a higher temperature resolution used to monitor field experiments.Periodic CHERT measurements are carried out between the piezometer equipped with electrodes, resultingin parallel and perpendicular vertical cross sections of the site resistivity. The position of the fresh-salt waterinterface can be identified due to the resistivity contrast between the saline and fresh water. Preliminary resultsof periodic distributed temperature measurements will be also be used to monitor the position of the mixing zonethanks to the contrast and seasonal temperature changes. Periodic down-hole EC profiles will be used to validatethe method.AcknowledgementsThis work was funded by the projects CGL2013-48869-C2-1 y CGL2013-48869-C2-2-R of the Spanish Government.We would like to thank SIMMAR (Serveis Integrals de Manteniment del Maresme) and the ConsellComarcal del Maresme in the construction of the research site
European Geosciences Union General Assembly 2016
Vienne, Austria

insu-01308757
https://hal-insu.archives-ouvertes.fr/insu-01308757

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Orogenic wedges locally present chaotic tectonostratigraphic units that contain exotic blocks of various size, origin, age and lithology, embedded in a sedimentary matrix. The occurrence of ophiolitic blocks, sometimes huge, in such “mélanges” raises questions on (i) the mechanisms responsible for the incorporation of oceanic basement rocks into an accretionary wedge and (ii) the mechanisms allowing exhumation and redeposition of these exotic elements in “mélanges” during wedge growth.To address these questions, we present the results of a series of analogue experiments performed to characterize the processes and parameters responsible for accretion, exhumation and tectonosedimentary reworking of oceanic basement lithospheric fragments in an accretionary wedge.The experimental setup is designed to simulate the interaction between tectonics, erosion and sedimentation. Different configurations are applied to study the impact of various parameters, such as irregular oceanic floor due to structural inheritance, or the presence of layers with contrasted rheology that can affect deformation partitioning in the wedge (frontal accretion vs basal accretion) influencing its growth. Image correlation technique allows extracting instantaneous velocity field, and tracking of passive particles. By retrieving the particle paths determined from models, the pressure-temperature path of mélange units or elementary blocks can be discussed. The experimental results are then compared with observations from ophiolite-bearing mélanges in Taiwan (Lichi and Kenting mélanges) and Raman spectroscopy of carbonaceous material (RSCM) Thermometry data on rocks from the northern Apennines (Casanova mélange). A geological scenario is proposed following basic observations. The tectonic evolution of the retroside of doubly vergent accretionary wedges is mainly controlled by backthrusting and backfolding. The retro wedge is characterized by steep slopes that are prone to gravitational instabilities. It triggers submarine landslides inducing huge mass transfers. This erosion combined with backthrusting could favour exhumation of the ophiolitic fragments formerly accreted at the base of the wedge along the rough seafloor-sediments interface. Such an exhumed material can be reworked and deposited as debris- flows in proximal basins located at the foot of the retrowedge slope forming a tectono-sedimentary mélange. These syntectonic basins are continuously deformed and involved in prograding backthrusting-induced deformation.
ISSN: 0264-3707

hal-01395127
https://hal.archives-ouvertes.fr/hal-01395127
DOI : 10.1016/j.jog.2016.05.008

Éditeur(s) : HAL CCSD Oxford University Press
Résumé : International audience
We report on a fatal invasive infection due to the ascomycetous fungus Neocosmospora vasinfecta, in a 20-year-old European patient suffering from an acute lymphoblastic leukemia. The infection could not be controlled by a bitherapy combining liposomal amphotericin B and voriconazole. This is the second case of disseminated infection reported with this unusual fungus, which develops under its teleomorphic state, is fully resistant to all systemic antifungals, and which is known to live in tropical countries.
ISSN: 1369-3786

hal-01101419
https://hal.archives-ouvertes.fr/hal-01101419
PUBMED : 24432214

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Diamond-bearing UHP metamorphic rocks witness for subduction of lithospheric slabs into the mantle and their return to shallow levels. In this study we present U–Pb and trace elements analyses of zircon and rutile inclusions from a diamond-bearing garnet megacryst collected in a mélange unit exposed on the northern margin of Africa (Edough Massif, NE Algeria). Large rutile crystals (up to 300 μm in size) analyzed in situ provide a U–Pb age of interpreted as dating the prograde to peak subduction stage of the mafic protolith. Trace element analyses of minute zircons (≤30 μm) indicate that they formed in equilibrium with the garnet megacryst at a temperature of 740–810 °C, most likely during HP retrograde metamorphism. U–Pb analyses provide a significantly younger age of attributed to exhumation of the UHP units. This study allows bracketing the age of UHP metamorphism in the Western Mediterranean Orogen to the Oligocene/early Miocene, thus unambiguously relating UHP metamorphism to the Alpine history. Exhumation of these UHP units is coeval with the counterclockwise rotation of the Corsica–Sardinia block and most likely resulted from subduction rollback that was driven by slab pull.
ISSN: 0012-821X

hal-01622789
https://hal.archives-ouvertes.fr/hal-01622789
DOI : 10.1016/j.epsl.2017.06.043

Éditeur(s) : HAL CCSD Inter Research
Résumé : International audience
The main objective of the VULSACO (VULnerability of SAndy COasts to climate change and anthropic pressure) project was to investigate present day and potential future vulnerability of sandy coasts at the 2030 horizon, i.e. on a time scale related to climate variability. The method, based on a multidisciplinary approach bringing together geologists, geographers, physicists, social psychologists, engineers and stakeholders, was structured around 4 axes: field data analysis; numerical modelling; analysis of governance and stakeholder perceptions; and development of vulnerability indexes. This approach was designed to investigate vulnerability at a local scale and was applied to 4 contrasting beaches located in France: Sète Lido (Mediterranean Sea), Truc Vert and La Tresson beaches (Atlantic Ocean), and Dewulf (English Channel). The results focus on decadal and multi-annual beach trends at the Truc Vert beach site. There is almost no trend in beach volume at Truc Vert beach, although there is a variation in this parameter on a cycle of 2 to 3 yr, with variations related to wave energy and probably to indexes of climate variability. Numerical modelling identified the sensitivity of beach responses to changes in wave height and direction, especially in terms of subtidal morphology and the potential development of shoreline instability. Together with the observed offshore wave angle at the Biscay Buoy, these model results suggest that a potential change in wave angle due to climate variability could significantly modify the bars' morphology. The combination of data analysis and numerical modelling contributed to the development of vulnerability indexes designed for sandy coasts, which take into account climate-dependant variables such as waves. This allowed the differentiation of the sites in terms of vulnerability to erosion: Sète Lido and Truc Vert beach were the most and least vulnerable sites, respectively. These indexes help in identifying the dominant components of beach vulnerability, and provide potential for the study of how anthropogenic factors affect vulnerability. The study of stakeholder perceptions and decision-making with regard to climate-related risk also highlighted potential anthropogenic effects on beach vulnerability, and identified possible site-specific outcomes.
ISSN: 0936-577X

hal-00843946
https://hal-brgm.archives-ouvertes.fr/hal-00843946
DOI : 10.3354/cr01153

Résumé : The necessity of improving knowledge in fisheries and especially small-scale coastal fisheries in order to analyse the conditions for their sustainable development is increasingly recognized. The three main requirements for the sustainable development of fisheries are the simultaneous present and future well being of the bio-ecological system, the human system and the management process. Knowledge on these aspects of small-scale coastal fisheries (SSCF) in Europe is generally limited, although there has been an improvement in information on the fishing sector and inshore marine resources due to the EU Data Collection Regulations (DCR) 1. SSCF are strongly represented in all EU Member States (81% and 87% of the EU 25 whole fleet is composed of vessels less than 12 and 15 meters respectively)2 and approximately 100,000 crew are involved in SSCF in Europe. SSCF are present all around the European coast, even in isolated and sensitive areas.

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/2007/rapport-6348.pdf
http://archimer.ifremer.fr/doc/00141/25204/23312.pdf
http://archimer.ifremer.fr/doc/00000/6348/