Résumé : The slides were taken on collecting trips sponsored by the William L. Bryant Foundation, where books, music and art indigenous to the regions were gathered. The are organized by geographical location.
A Jamaican man traveling on a donkey on a seaside road along Jamaica's East coast. The paved street is lined with palm trees, almond trees, and electric power lines. Slide labeled Jam. east coast.
Jamaica -- Caribbean region

Droits : All rights to images are held by the respective holding institution. This image is posted publicly for non-profit educational uses, excluding printed publication. For permission to reproduce images and/or for copyright information contact Special Collections & University Archives, University of Central Florida Libraries, Orlando, FL 32816 phone (407) 823-2576, email: speccoll@mail.ucf.edu
CFM1972_01a
http://ufdc.ufl.edu/AA00030859/00001

Résumé : The slides were taken on collecting trips sponsored by the William L. Bryant Foundation, where books, music and art indigenous to the regions were gathered. The are organized by geographical location.
Mechanical cranes are being used to load harvested sugarcane into the beds of awaiting trucks in Jamaica. In the distance are mountains, electrical power lines, and buildings. Slide labeled Jam. Cane.
Jamaica -- Caribbean region

Droits : All rights to images are held by the respective holding institution. This image is posted publicly for non-profit educational uses, excluding printed publication. For permission to reproduce images and/or for copyright information contact Special Collections & University Archives, University of Central Florida Libraries, Orlando, FL 32816 phone (407) 823-2576, email: speccoll@mail.ucf.edu
CFM1972_01a
http://ufdc.ufl.edu/AA00030877/00001

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Seven male subjects volunteered to participate in an investigation of whether the diurnalincrease in core temperature influences the effects of pre-cooling or passivewarm-up on muscular power. Morning (07:00-09:00 h) and afternoon (17:00-19:00 h) evaluation of maximal power output during a cycling sprint was performed on different days in a control condition (room at 21.8 °C, 69% rh), after 30 min of pre-cooling in a cold bath (16 °C), or after 30 min of passivewarm-up in a hot bath (38 °C). Despite an equivalent increase from morning to afternoon in core temperature in all conditions (+0.4 °C, P < 0.05), power output displayed a diurnalincrease in control condition only. A local cooling or heating of the leg in a neutral environment blunted the diurnal variation in muscular power. Because pre-cooling decreases muscle power, force and velocity irrespective of time-of-day, athletes should strictly avoid any cooling before a sprint exercise. In summary, diurnal variation in muscle power output seems to be more influenced by muscle rather than core temperature.
ISSN: 1440-2440

hal-00706159
https://hal.univ-antilles.fr/hal-00706159
DOI : 10.1016/j.jsams.2007.09.008

Résumé : The slides were taken on collecting trips sponsored by the William L. Bryant Foundation, where books, music and art indigenous to the regions were gathered. The are organized by geographical location.
Image showcases the use of a donkey for transportation in rural Jamaica. The donkey has a crocus bag saddle with a rope harness. The man riding the donkey is carrying sugarcane and herbs. The paved street is lined with palm trees, almond trees, and electric power lines. Slide labeled Jam. east coast.
Jamaica -- Caribbean region

Droits : All rights to images are held by the respective holding institution. This image is posted publicly for non-profit educational uses, excluding printed publication. For permission to reproduce images and/or for copyright information contact Special Collections & University Archives, University of Central Florida Libraries, Orlando, FL 32816 phone (407) 823-2576, email: speccoll@mail.ucf.edu
CFM1972_01a
http://ufdc.ufl.edu/AA00030858/00001

Éditeur(s) : Pêche thonière et dispositifs de concentration de poissons, Caribbean-Martinique, 15-19 Oct 1999
Résumé : Tuna world fisheries yield 3 million tons per year; the increase rate of whole production is constant and sustained since 30 years. This original figure for marine fisheries is due to enlargement of tuna fleets and fishing grounds over all the world ocean, the continuous increase of tuna fishing power by in board equipment and remote sensing equipment for searching and scouting (on board, aircraft, satellite, telecommunication_). During the last 20 years, the log-associated tuna fishing has contributed to the local individual and tuna fleets efficiency and fishing power either for large industrial tuna seiners by radio-equipped buoys on natural (debris) or artificial man-made logs. The same trend is noted for numerous artisanal tuna and large pelagic coastal fisheries on moored fishing aggregating devices and networks. The first part of the paper is a review of data and results to assess and rank the "Surfaces prospected by in board tuna seiners and associated aircraft and satellite technics" (visual, radar, sar-radar and satellite altimetry sensors). The final objective is the comparison with the surfaces and volumes associated to fads. Since 20 years, tuna ecology and behaviour data from ultrasonic tagging (short-term depth/distance/time migration around logs and fads) are used for fishing of tuna associated with floating objects, namely fads. The second part of this paper is an "Assessment of fad's aggregating associated surface and volume" linked with oceanographic data: large oceanic geostrophic current and observed drift speed of radio-equipped fads in the Indian Ocean. Using the available data on fads, tuna fishing technology linked with oceanographic and biological data results from ultrasonic tuna tracking experiments, the paper is an attempt to identify and place the fads technology in the scale of tuna fishing devices as a contribution to the increase of tuna fishing power either individual tuna boat or tuna fleets.Original Abstract: La production mondiale des pecheries thonieres est actuellement de l'ordre de 3 millions de tonnes par an et conserve depuis pres de 50 ans un taux de croissance annuel soutenu. Cette croissance, exceptionnelle pour un secteur des peches maritimes, est due a plusieurs causes: accroissement des effectifs et des puissances de peche des grandes flottes thonieres industrielles oceaniques qui exploitent les ressources thonieres de l'ocean mondial et le developpement conjoint de nouvelles techniques de peche et de nouvelles technologies d'aide a la peche, telles que les dispositifs de concentration de poissons (DCP). L'accroissement de la puissance individuelle des navires est du au developpement de la construction navale (mecanisation, propulsion, hydraulique, conservation et traitement a borda) et a l'utilisation d'une gamme diversifiee d'aides a la peche : navigation, telecommunication, localisation des zones favorables, detection visuelle ou radiometrique assistee par equipement a bord, en helicoptere et avion, detection acoustique, detection par radar de bord, radar-avion ou, a terme, antenne SAR sur satellite. Plus recemment, soit depuis 20 ans, les caracteristiques du comportement, migration de court terme, agregation et concentration des poissons pelagiques, fixation et retention des bancs de thons, sont utilisees, par les dispositifs de concentration de poissons (DCP) ancres ou derivants. Cette contribution a pour objectif de situer et placer les DCP fixes ou derivants sur cet ensemble de techniques d'aide a la peche thoniere. Les donnees pour cet essai de classement sont d'ordres biologique, ethologique et comportementaux (amplitude de deplacement des thons et dimension de la sphere d'attraction d'un DCP) et d'ordres environnemental et oceanographique : masse d'eau concernee par un DCP dans une large veine de courant oceanique ou cotier. On tente de quantifier et d'ordonner les surfaces et les volumes prospectes par les thoniers et particulierement les volumes et masses d'eau exploites par les thoniers utilisant des DCP. Ce classement des DCP dans la serie des dispositifs d'aide a la peche thoniere facilitera l'appreciation de leur contribution a l'augmentation des puissances de peche des thoniers.

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/00042/15297/12656.pdf
http://archimer.ifremer.fr/doc/00042/15297/

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
Benthic microbial fuel cells (BMFCs) are continuous electricity generators using electroactive microorganisms and organic matter from aquatic environment, respectively, as catalysts and substrate. In this paper, first a low-cost PVC-made structure is constructed to harvest electricity from mangrove environment located in French Guiana. An in situ BMFC has given power density of 30 mW/m2 of the anodic surface area. This performance has been confirmed by experience in laboratory where inter-electrode distance and electrode surface area appeared to be power increasing factors. However, the output power of one BMFC is not used to supply real devices such as autonomous sensors. Second, to meet this expectation, in parallel and in series associations were considered. These associations were made in order to increase the output voltage and consequently the power, to reach levels that can supply small sensors (about 3 V). Finally, to improve the performance of the series association and to avoid the voltage reversal phenomenon, a voltage balancing circuit was simulated and added to the series connections. With balancing method, the cell voltage of BMFCs can be equalized, and the performances can be improved. This allows an optimal energy harvesting and a better global efficiency of the set.
ISSN: 0363-907X

hal-01683128
https://hal.univ-antilles.fr/hal-01683128
DOI : 10.1002/er.3270

Résumé : The slides were taken on collecting trips sponsored by the William L. Bryant Foundation, where books, music and art indigenous to the regions were gathered. The are organized by geographical location.
The remains of an old water-powered stone sugar mill in Jamaica. Water from the mill is flowing into a pond. Slide labeled old sugar mill.
Jamaica -- Caribbean region

Droits : All rights to images are held by the respective holding institution. This image is posted publicly for non-profit educational uses, excluding printed publication. For permission to reproduce images and/or for copyright information contact Special Collections & University Archives, University of Central Florida Libraries, Orlando, FL 32816 phone (407) 823-2576, email: speccoll@mail.ucf.edu
CFM1972_01a
http://ufdc.ufl.edu/AA00030890/00001

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Wind energy production is very sensitive to instantaneous wind speed fluctuations. Thus rapid variation of wind speed due to changes in the local meteorological conditions can lead to electrical power variations of the order of the nominal power output. The high variability of this renewable energy source can caused a disruptive effect on power quality and reliability, in non-interconnected island networks as in Guadeloupe (French West Indies). To palliate these difficulties, it is essential to identify and characterize the wind speed distribution over very short time intervals. This allows anticipating the eventuality of power shortage or power surge. Therefore, it is of interest to categorize wind speed fluctuations into distinct classes and to estimate the probability of a distribution to belong to a class. This paper presents a method for classifying wind speed distributions by estimating a finite mixture of Dirichlet distributions. The SAEM algorithm that we use provides a fine distinction between three wind speed distribution classes. It is a new nonparametric method for wind speed classification.
ISSN: 0960-1481

hal-01527881
https://hal.archives-ouvertes.fr/hal-01527881
DOI : 10.1016/j.renene.2011.03.024

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Wind energy production is very sensitive to turbulent wind speed. Thus rapid variation of wind speed due to changes in the local meteorological conditions can lead to electrical power variations of the order of the nominal power output, in particular when wind power variations on very short time scales, range at few seconds to 1 h, are considered. In small grid as they exist on islands (Guadeloupean Archipelago: French West Indies) such fluctuations can cause instabilities in case of intermediate power shortages. The developed analysis in [14] reveals three main classes of time series for the wind speed fluctuations. In this work, Probability Density Functions (PDFs) are proposed to fit the wind speed fluctuations distributions in each class. After, to simulate wind speed fluctuations sequences, we use a stochastic differential equation, the Langevin equation considering Gaussian turbulence PDF (class I), Gram–Charlier PDF (class II) and a mixture of gaussian PDF (class III). The statistical and dynamical properties of simulated wind sequences are close to those of measured wind sequences, for each class
ISSN: 0306-2619

hal-01527885
https://hal.archives-ouvertes.fr/hal-01527885
DOI : 10.1016/j.apenergy.2012.05.007

Résumé : The slides were taken on collecting trips sponsored by the William L. Bryant Foundation, where books, music and art indigenous to the regions were gathered. The are organized by geographical location.
Six oxen pull a sugarcane filled cart along a road in Jamaica. Electric power lines and coconut trees can be seen. Slide labeled Sugar Cane.
Jamaica -- Caribbean region

Droits : All rights to images are held by the respective holding institution. This image is posted publicly for non-profit educational uses, excluding printed publication. For permission to reproduce images and/or for copyright information contact Special Collections & University Archives, University of Central Florida Libraries, Orlando, FL 32816 phone (407) 823-2576, email: speccoll@mail.ucf.edu
CFM1972_01a
http://ufdc.ufl.edu/AA00030875/00001

Éditeur(s) : HAL CCSD MDPI
Résumé : International audience
The Taylor power law (or temporal fluctuation scaling), is a scaling relationship of the form σ ~ (P)λ where !! is the standard deviation and hPi the mean value of a sample of a time series has been observed for power output data sampled at 5 min and 1 s and from five wind farms and a single wind turbine, located at different places. Furthermore, an analogy with the turbulence field is performed, consequently allowing the establishment of a scaling relationship between the turbulent production IP and the mean value (P)
ISSN: 2079-9276

hal-01528077
https://hal.archives-ouvertes.fr/hal-01528077
https://hal.archives-ouvertes.fr/hal-01528077/document
https://hal.archives-ouvertes.fr/hal-01528077/file/resources-04-00787.pdf
DOI : 10.3390/resources4040787

Résumé : The slides were taken on collecting trips sponsored by the William L. Bryant Foundation, where books, music and art indigenous to the regions were gathered. The are organized by geographical location.
This photograph shows a large building which is part of Havana's public square, which was originally called la Plaza Cívica (Civic Square), but after the Cuban Revolution was renamed "Plaza de la Revolución" or "Revolution Square." The large tower is a memorial to Jose Marti, which was erected during the Presidency of Fulgencio Batista. The square and the memorial were completed in 1959, the year that Fidel Castro came to power. This picture includes many vehicles of the 1950. In front of the building are two billboards. The billboard on the right is a political ad for, then president Batista. It reads "Paz, Trabajo, progreso" - meaning "Peace, Work and Progress."
The 109 m (358 ft) tower, designed by a team of architects led by Enrique Luis Varela, is in the form of a five-pointed star, encased in grey Cuban marble from the Isla de la Juventud.
Cuba -- Caribbean region -- Havana

Droits : All rights to images are held by the respective holding institution. This image is posted publicly for non-profit educational uses, excluding printed publication. For permission to reproduce images and/or for copyright information contact Special Collections & University Archives, University of Central Florida Libraries, Orlando, FL 32816 phone (407) 823-2576, email: speccoll@mail.ucf.edu
CFM1972_01a
Sheet 26: 17
http://ufdc.ufl.edu/CA01200416/00001

Éditeur(s) : HAL CCSD
Résumé : International audience
This paper shows how the notion of “local site of a question” helps the teacher to get into this question in order to teach it. We discuss the relationship between the description of what has to be deeply known to answer the difficulties or the obstacles which arise for the pupils during the study of a question, and what Shulman, and his successors, model under the name of pedagogical content knowledge. A survey, conducted among current French teachers, shows how they are powerless when facing the difficulties of their pupils and a study of some old teaching books shows how this problem was addressed in former teaching practices. Based on these results, we open the discussion of the training of the teachers.
L’article montre l’usage possible de la notion de « site local d’une question » dans le travail du professeur se préparant à enseigner cette question. On discute à cette occasion les proximités entre la description de ce qu’il y a à savoir profondément, pour répondre aux difficultés ou obstacles que rencontreront les élèves au cours de l’étude d’une question, et ce que Shulman et ses successeurs modélisent sous le terme de « pedagogical content knowledge ». Une enquête auprès de professeurs actuels montre comment ils sont démunis face aux difficultés des élèves, et une enquête dans des ouvrages d’enseignement anciens montre comment le problème soulevé a été traité en pratique par l’enseignement traditionnel. L’article discute alors le problème de la formation que les professeurs seraient en droit d’attendre.
Education & Didactique

hal-01530862
https://hal.univ-antilles.fr/hal-01530862

Éditeur(s) : HAL CCSD
Résumé : Geothermal energy is considered as a green and infinite energy source at human scale. Currently, the yield of geothermal power plants is limited to temperatures of the operating fluid which 350 °C. From tectonic and volcanic activity at mid-ocean ridges, Iceland is a location where supercritical fluid extraction (T> 375 °C) can considered for the near future. Exploiting such fluids could theoretically multiply by a factor of ten the electrical power delivered by geothermal wells. Can such fluids circulate at the base of brittle oceanic crust? This work investigates the petrophysical properties of basalts in order to constrain geophysical observations in Iceland and predict the behavior of very high temperature geo-hydrothermal reservoirs. The first approach consisted in studying the physical properties of rocks that have hosted deep hydrothermal circulations at oceanic ridges. The study of these rocks at ODP Site 1256 shows that the porosity measured both in the field and in the lab is associated with amphibolite facies alteration minerals (T> 500 ° C). The second approach was to recreate in the laboratory the conditions of pressure, temperature and pore fluid pressure of high temperature to supercritical hydrothermal systems to predict the mechanical and electrical properties of basalts under these conditions. The mechanical results indicate that the brittle/ductile transition occurs at a temperature of about 550° C, where a strong permeability decrease is expected. The implementation and calibration of a new cell for measuring electrical conductivity at high temperature provide the first results for the interpretation of geophysical data. When applied to basaltic crustal conditions in Iceland, these results indicate that hydrothermal fluids could circulate, at least temporarily, in a supercritical state up to 5 km depth.
La géothermie est considérée comme une source d'énergie propre et inépuisable à échelle humaine. Actuellement, le rendement des centrales géothermiques est limité à l'exploitation de fluides de températures inférieures à 350 °C. L'association de l'activité tectonique et volcanique aux dorsales océaniques fait de l'Islande un lieu où l'extraction de fluides supercritiques (T> 375 °C) peut être envisagée. Cette exploitation pourrait multiplier par dix la puissance électrique délivrée par le système géothermal. Ces fluides peuvent-ils circuler dans la croûte océanique ? Ce travail propose de contraindre les observations géophysiques et de prédire le fonctionnement des réservoirs géo-hydrothermaux de très haute température par l'étude des propriétés physiques des basaltes. La première approche est focalisée sur l'étude de roches ayant accueilli une circulation hydrothermale par le passé. L'étude de ces roches au site ODP 1256, montre que leur porosité est associée à la présence de minéraux d'altération hydrothermale du facies amphibolite (T> 500 °C). La seconde approche a consisté à recréer, en laboratoire, les conditions des systèmes hydrothermaux, à très haute température, afin de prédire les propriétés mécaniques et électriques des basaltes dans ces conditions. Les résultats mécaniques indiquent que la transition fragile/ductile, souvent associée à une forte décroissance de perméabilité, intervient à une température d'environ 550 °C. La mise en place d'une cellule de mesure de la conductivité électrique de haute température a fourni les premiers résultats utiles à l'analyse des données géophysiques. Appliqués aux conditions de la croûte basaltique Islandaise, ces résultats indiquent que des fluides hydrothermaux pourraient circuler au moins transitoirement à l'état supercritique jusqu'à ~ 5 km de profondeur.
https://tel.archives-ouvertes.fr/tel-00591798

tel-00591798
https://tel.archives-ouvertes.fr/tel-00591798
https://tel.archives-ouvertes.fr/tel-00591798/document
https://tel.archives-ouvertes.fr/tel-00591798/file/THESE_MV_pro.pdf

Éditeur(s) : HAL CCSD American Geophysical Union
Résumé : International audience
The Oman ophiolite is regarded as derived from a fast spreading oceanic ridge. As in its present-day marine analogs, expectedly, the gabbro unit crystallized in a large magma chamber underneath a small melt lens. In ophiolites, this melt lens is reduced to a horizon mapped in the field, where the floor and the roof of the melt lens joined. The magmatic activity of the former melt lens has been studied in gabbros located below the melt lens horizon. Beneath a stable melt lens, gabbros subside and drift through the steep walls of the magma chamber as steeply foliated gabbros. In contrast, in unstable melt lenses more specifically considered here, flat-lying gabbros are exposed beneath the lens. These gabbros were settling on the floor while the melt lens was retreating. Their strong magmatic foliations and lineations point to a dynamic deposition on the floor, and lineation trends record the structure of convection rolls within the lens. Time constraints suggest a similar to 100 year periodicity of melt recharge by short and powerful melt pulses followed by a shorter time of convection activity after recharge and a longer period of static magma settling, as recently proposed for the East Pacific Rise. At each new melt pulse, the lens nearly doubles its volume by surface expansion, within a short time lapse, before slowly and progressively retreating to feed crustal accretion. Large horizontal surface inflation of the lens better explains the seawater hydration of the accreting crust than melt lens vertical motion through the lid.
ISSN: 0148-0227

hal-00617452
https://hal.archives-ouvertes.fr/hal-00617452
DOI : 10.1029/2010JB007934

Éditeur(s) : HAL CCSD Nature Publishing Group
Résumé : International audience
Meiotic recombination predominantly occurs at discrete genomic loci called recombination hotspots, but the features defining these areas are still largely unknown (reviewed in refs 1-5). To allow a comprehensive analysis of hotspot-associated DNA and chromatin characteristics, we developed a direct molecular approach for mapping meiotic DNA double-strand breaks that initiate recombination. Here we present the genome-wide distribution of recombination initiation sites in the mouse genome. Hotspot centres are mapped with approximately 200-nucleotide precision, which allows analysis of the fine structural details of the preferred recombination sites. We determine that hotspots share a centrally distributed consensus motif, possess a nucleotide skew that changes polarity at the centres of hotspots and have an intrinsic preference to be occupied by a nucleosome. Furthermore, we find that the vast majority of recombination initiation sites in mouse males are associated with testis-specific trimethylation of lysine 4 on histone H3 that is distinct from histone H3 lysine 4 trimethylation marks associated with transcription. The recombination map presented here has been derived from a homogeneous mouse population with a defined genetic background and therefore lends itself to extensive future experimental exploration. We note that the mapping technique developed here does not depend on the availability of genetic markers and hence can be easily adapted to other species with complex genomes. Our findings uncover several fundamental features of mammalian recombination hotspots and underline the power of the new recombination map for future studies of genetic recombination, genome stability and evolution.
ISSN: 0028-0836

hal-00877681
https://hal.archives-ouvertes.fr/hal-00877681
DOI : 10.1038/nature09869
PUBMED : 21460839

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
A good knowledge of the intermittency of global solar radiation is crucial for selecting the location of a solar power plant and predicting the generation of electricity. This paper presents a multifractal analysis study of 367 daily global solar radiation sequences measured with a sampling rate of 1 Hz over one year at Guadeloupean Archipelago (French West Indies) located at 16 150N latitude and 60 300W longitude. The mean power spectrum computed follows a power law behavior close to the Kolmogorov spectrum. The intermittent and multifractal properties of global solar radiation data are investigated using several methods. Under this basis, a characterization for each day using three multifractal parameters is proposed.
ISSN: 0038-092X

hal-00903410
https://hal.archives-ouvertes.fr/hal-00903410
DOI : 10.1016/j.solener.2013.09.018

Éditeur(s) : HAL CCSD Springer
Résumé : International audience
Wind energy production is very sensitive to turbulent wind, in particular when wind power variations range from few seconds to 1 hour, are considered. Indeed rapid changes in the local meteorological condition as observed in tropical climate can provoke large variations of wind speed. Consequently the electric grid security can be jeopardized due to these fluctuations. This is particularly the case of island networks as in the Guadeloupean archipelago (French West Indies) where the installed 20 MW wind power already represents 11% of the electrical consumption. From 1 million wind sequences of duration 10 minutes, sampled at 1 Hz during the trade season, we proceed toward two objectives: i) the characterization of the wind speed sequences, ii) the dynamical simulation of the wind sequences using Langevin equation.
Progress in Turbulence and Wind Energy IV

ISBN : 978-3-642-28968-2.
hal-01527883
https://hal.archives-ouvertes.fr/hal-01527883
DOI : 10.1007/978-3-642-28968-2-50

Éditeur(s) : HAL CCSD American Geophysical Union
Résumé : International audience
Knowing the slip amplitudes that large earthquakes produced in prehistorical times is one key to anticipate the magnitude of large forthcoming events. It is long known that the morphology is preserving remnants of paleoearthquake slips in the form of fault-offset landforms. However, the measured offsets that can be attributed to the most recent paleoearthquakes are generally few along a fault, so that they rarely allow recovering the slip distributions and largest slips of these earthquakes. We acquired ~1 m resolution airborne lidar data on a 30 km stretch of a fast-slipping strike-slip fault (eastern Hope Fault, New Zealand) located in a region of high alluvial dynamics where landforms are rapidly evolving. Data analysis reveals >200 offset landforms; only 30% allow a good to moderate quality offset measurement. From these good to moderate quality measures, we recover the slip-length distributions and largest slips of the four most recent large paleoearthquakes and find evidence of 4–6 prior events. The record suggests that large earthquake slip recurred in multiples of about 4 m along the 30 km stretch. Although they have larger uncertainties, the more numerous lower-quality offsets that we also measured reveal a similar earthquake slip record. This shows that, although offset landforms are partly degraded in dynamically active landscapes, they store valuable information on paleoearthquake slips. This information might be recovered provided that the morphology is analyzed at high resolution and " continuously " over a significant fault length. Remote lidar data are powerful to perform such analyses.
ISSN: 2169-9313

insu-01469219
https://hal-insu.archives-ouvertes.fr/insu-01469219
https://hal-insu.archives-ouvertes.fr/insu-01469219/document
https://hal-insu.archives-ouvertes.fr/insu-01469219/file/Manighetti_et_al-2015-Journalsur Geophysical_Research__Solid_Earth.pdf
DOI : 10.1002/2014JB011787

Éditeur(s) : HAL CCSD American Society for Biochemistry and Molecular Biology
Résumé : International audience
Background: We used evolutionary analysis of alkaline phosphatase (tissue nonspecific alkaline phosphatase, TNSALP) to predict missense mutations leading to hypophosphatasia. Results: We found 469 sensitive positions and validated 99% of the 204 known mutations. Conclusion: It is a more powerful method than in silico models to validate missense mutations in TNSALP. Significance: Such an approach should be widely used to support genetic diagnostics. ALPL encodes the tissue nonspecific alkaline phosphatase (TNSALP), which removes phosphate groups from various substrates. Its function is essential for bone and tooth mineralization. In humans, ALPL mutations lead to hypophosphatasia, a genetic disorder characterized by defective bone and/or tooth mineralization. To date, 275 ALPL mutations have been reported to cause hypophosphatasia, of which 204 were simple missense mutations. Molecular evolutionary analysis has proved to be an efficient method to highlight residues important for the protein function and to predict or validate sensitive positions for genetic disease. Here we analyzed 58 mammalian TNSALP to identify amino acids unchanged, or only substituted by residues sharing similar properties, through 220 millions years of mammalian evolution. We found 469 sensitive positions of the 524 residues of human TNSALP, which indicates a highly constrained protein. Any substitution occurring at one of these positions is predicted to lead to hypophosphatasia. We tested the 204 missense mutations resulting in hypophosphatasia against our predictive chart, and validated 99% of them. Most sensitive positions were located in functionally important regions of TNSALP (active site, homodimeric interface, crown domain, calcium site, ...). However, some important positions are located in regions, the structure and/or biological function of which are still unknown. Our chart of sensitive positions in human TNSALP (i) enables to validate or invalidate at low cost any ALPL mutation, which would be suspected to be responsible for hypophosphatasia, by contrast with time consuming and expensive functional tests, and (ii) displays higher predictive power than in silico models of prediction.
ISSN: 0021-9258

hal-01545479
https://hal.archives-ouvertes.fr/hal-01545479
DOI : 10.1074/jbc.M114.576843