Éditeur(s) : HAL CCSD
Résumé : The aim of this thesis is to analyze the variations in slip rates along strike-slip faults, in intracontinental domain, producing large earthquakes (M > 7.5). To illustrate these variations, this work has focused in two area located in the most tectonically active continental domains in the world: in the western part of Mongolia (Bogd and Bulnay faults) and in the northern part of Iran (Astaneh and Tabriz faults). Using morphotectonic and paleoseismological analyses, the kinematics, the slip rates and the recurrence times have been estimated and allow us to describe the characteristics of seismic cycle along these faults. In Mongolia, the slip rates are estimated at ~ 1,2 and ~ 2,6 mm/yr along the Bogd and the Bulnay faults, respectively, with no variations of geological slip rates over the late Pleistocene-Holocene period. These two faults present characteristic slips and similar recurrence times between large earthquakes. The paleoseismological investigations suggest that a cluster occurred 3000 years ago, similar to the seismic cluster recorded in Mongolia during the XX century. In Iran, the slip rate was estimated to 2 mm/yr along the Astaneh fault and the recurrence times are ranging from 1600 to 2200 years, associated with offsets comprised between 3 and 4,5 m. We have also estimated a slip rate of ~ 7 mm/yr along the Tabriz fault, in agreement with the present day rate estimated by GPS, suggesting no variations in the slip rate over the past 45 ka.
Ce travail de thèse a pour but d'analyser les variations de vitesses sur des grandes failles décrochantes en contexte intracontinental, capables de produire des séismes de très fortes magnitudes (M > 7.5). Afin d'illustrer ces variations d'activités, cette analyse a été effectuée sur deux zones d'études situées en domaine continental et sismiquement actives: la région ouest de la Mongolie (failles de Bogd et Bolnay) et le nord de l'Iran (failles d'Astaneh et de Tabriz). À partir d'une approche morphotectonique et paléosismologique, les cinématiques, les vitesses de failles et les intervalles de récurrence entre les séismes majeurs ont été estimés, permettant d'analyser les caractéristiques du cycle sismique sur chacune des failles. En Mongolie, les failles de Bogd et Bolnay présentent respectivement des vitesses de ~ 1,2 et 2,6 mm/an, qui semblent être constantes sur la période Pleistocène supérieur-Holocène. Ces deux failles présentent également des glissements caractéristiques et des intervalles de temps similaires entre les séismes majeurs. Les analyses paléosismologiques suggèrent qu'un essaim sismique comparable à celui enregistré au XXème siècle a eu lieu il y a environ 3000 ans. En Iran, une vitesse géologique de 2 mm/an a été estimée sur la faille d'Astaneh et les données paléosismologiques suggèrent des intervalles de récurrence de 1800 ans, associés à des déplacements en surface compris entre 3 et 4,5 m. Nous avons également estimé une vitesse de 7 mm/an sur la faille de Tabriz, en accord avec les données GPS, suggérant que la vitesse sur cette faille est constante depuis 45 ka.
https://tel.archives-ouvertes.fr/tel-00591794

tel-00591794
https://tel.archives-ouvertes.fr/tel-00591794
https://tel.archives-ouvertes.fr/tel-00591794/document
https://tel.archives-ouvertes.fr/tel-00591794/file/these_rizza.pdf

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Leg ulcer is a disabling complication in patients with sickle cell anemia (SCA) but the exact pathophysiological mechanisms are unknown. The aim of this study was to identify the hematological and hemorheological alterations associated with recurrent leg ulcers. Sixty-two SCA patients who never experienced leg ulcers (ULC-) and 13 SCA patients with a positive history of recurrent leg ulcers (ULC+) - but with no leg ulcers at the time of the study - were recruited. All patients were in steady state condition. Blood was sampled to perform hematological, biochemical (hemolytic markers) and hemorheological analyses (blood viscosity, red blood cell deformability and aggregation properties). The hematocrit-to-viscosity ratio (HVR), which reflects the red blood cell oxygen transport efficiency, was calculated for each subject. Patients from the ULC+ group were older than patients from the ULC- group. Anemia (red blood cell count, hematocrit and hemoglobin levels) was more pronounced in the ULC+ group. Lactate dehydrogenase level was higher in the ULC+ group than in the ULC- group. Neither blood viscosity, nor RBC aggregation properties differed between the two groups. HVR was lower and RBC deformability tended to be reduced in the ULC+ group. Our study confirmed increased hemolytic rate and anemia in SCA patients with leg ulcers recurrence. Furthermore, our data suggest that although systemic blood viscosity is not a major factor involved in the pathophysiology of this complication, decreased red blood cell oxygen transport efficiency (i.e., low hematocrit/viscosity ratio) may play a role.
ISSN: 1932-6203

inserm-00922105
http://www.hal.inserm.fr/inserm-00922105
http://www.hal.inserm.fr/inserm-00922105/document
http://www.hal.inserm.fr/inserm-00922105/file/2013_Connes_-_Decreased_Hematocrit.pdf
DOI : 10.1371/journal.pone.0079680

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
We carried out morphotectonic studies along the left-lateral strike-slip Bogd Fault, the principal structure involved in the Gobi-Altay earthquake of 1957 December 4 (published magnitudes range from 7.8 to 8.3). The Bogd Fault is 260 km long and can be subdivided into five main geometric segments, based on variation in strike direction. West to East these segments are, respectively: the West Ih Bogd (WIB), The North Ih Bogd (NIB), the West Ih Bogd (WIB), the West Baga Bogd (WBB) and the East Baga Bogd (EBB) segments. Morphological analysis of offset streams, ridges and alluvial fans-particularly well preserved in the arid environment of the Gobi region-allows evaluation of late Quaternary slip rates along the different faults segments. In this paper, we measure slip rates over the past 200 ka at four sites distributed across the three western segments of the Bogd Fault. Our results show that the left-lateral slip rate is similar to 1 mm yr(-1) along the WIB and EIB segments and similar to 0.5 mm yr(-1) along the NIB segment. These variations are consistent with the restraining bend geometry of the Bogd Fault.;Our study also provides additional estimates of the horizontal offset associated with the 1957 earthquake along the western part of the Bogd rupture, complementing previously published studies. We show that the mean horizontal offset associated with the 1957 earthquake decreases progressively from 5.2 m in the west to 2.0 m in the east, reflecting the progressive change of kinematic style from pure left-lateral strike-slip faulting to left-lateral-reverse faulting. Along the three western segments, we measure cumulative displacements that are multiples of the 1957 coseismic offset, which may be consistent with a characteristic slip. Moreover, using these data, we re-estimate the moment magnitude of the Gobi-Altay earthquake at M-w 7.78-7.95.;Combining our slip rate estimates and the slip distribution per event we also determined a mean recurrence interval of similar to 2500-5200 yr for past earthquakes along the different segments of the western Bogd Fault. This suggests that the three western segments of the Bogd Fault and the Gurvan Bulag thrust fault (a reverse fault bounding the southern side of the Ih Bogd range that ruptured during the 1957 earthquake) have similar average recurrence times, and therefore may have ruptured together in previous earthquakes as they did in 1957. These results suggest that the western part of the Bogd Fault system, including the Gurvan Bulag thrust fault, usually behaves in a 'characteristic earthquake' mode.
ISSN: 0956-540X

hal-00639467
https://hal.archives-ouvertes.fr/hal-00639467
https://hal.archives-ouvertes.fr/hal-00639467v2/document
https://hal.archives-ouvertes.fr/hal-00639467/file/rizzaGJI2011.pdf
DOI : 10.1111/j.1365-246X.2011.05075.x

Éditeur(s) : HAL CCSD Elsevier
Résumé : Le titre a été changé Ancien titre: Roles for local crowding and pressure in counteracting density fluctuations at equilibrium
International audience
What is the probability that all the gas in a box accumulates in the same half of this box? Though amusing, this question underlies the fundamental problem of density fluctuations at equilibrium, which has profound implementations in many physical fields. The currently accepted solutions are derived from the studies of Brownian motion by Smoluchowski, but they are not appropriate for the directly colliding particles of gases. Two alternative theories are proposed here using self-regulatory Bernoulli distributions. A discretization of space is first introduced to develop a mechanism of matter congestion holding for high densities. In a second mechanism valid in ordinary conditions, the influence of local pressure on the location of every particle is examined using classical laws of ideal gases. This approach reveals that a negative feedback results from the reciprocal influences between individual particles and the population of particles, which strongly reduces the probability of atypical microstates. Finally, a thermodynamic quantum of time is defined to compare the recurrence times of improbable macrostates predicted through these different approaches.
Physica A: Statistical Mechanics and its Applications

hal-00920985
https://hal-univ-rennes1.archives-ouvertes.fr/hal-00920985
https://hal-univ-rennes1.archives-ouvertes.fr/hal-00920985v2/document
ARXIV : 1404.6223
DOI : 10.1016/j.physa.2014.03.067

Éditeur(s) : HAL CCSD AGU and the Geochemical Society
Résumé : International audience
The Ganos fault is the westernmost segment of the North Anatolian Fault that experienced the Mw = 7.4 earthquake of 9 August 1912. The earthquake revealed 45-km-long of surface ruptures inland, trending N70 E, and 5.5 m of maximum right lateral offset near Güzelköy. The long-term deformation of the fault is clearly expressed by several pull-apart basins and sag ponds, pressure and shutter ridges and offset streams. In parallel with detailed geomorphologic investigations, we measured co-seismic and cumulative displacements along the fault, and selected the Güzelköy site for paleoseismology. A microtopographic survey at the site yields 10.5 0.5 m and 35.4 1.5 m cumulative lateral offsets of stream channels and geomorphologic features. Seven paleoseismic parallel and cross-fault trenches document successive faulting events and provide the timing of past earthquakes on the Ganos fault segment. Radiocarbon dating of successive colluvial wedges in trench T1, and the fresh scarplet above (probably 1912 surface rupture) indicate the occurrence of three faulting events since the 14th century. Parallel trenches (3, 5, 6 and 7) expose paleo-channels and show a cumulative right-lateral offset of 16.5 1.5 m next to the fault, and 21.3 1.5 m total channel deflection. Radiocarbon dating of past channel units and fault scarp-related colluvial deposits imply an average 17 +/ 5 mm/year slip rate and 323 142 years recurrence interval of large earthquakes during the last 1000 years on the Ganos fault. The succession of past faulting events and inferred slip rate west of the Marmara Sea provide more constraint on the long-term faulting behavior in the seismic gap of the North Anatolian Fault and may contribute to a better seismic hazard assessment in the Istanbul region.
ISSN: 1525-2027

hal-00748218
https://hal.archives-ouvertes.fr/hal-00748218
DOI : 10.1029/2011GC003960

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
A network of continuous GPS stations has been installed in NW Iran since 2005 to complement the survey GPS network already existing in the region. We present the 1999-2009 GPS-derived velocity field for this region based on the continuous and survey-mode observations. The results confirm a right lateral slip of 7 +/- 1 mm/yr for the North Tabriz fault, in agreement with previous studies. This rate is consistent with earthquakes of magnitude 7-7.3 and recurrence times of 250-300 yr. The higher spatial coverage of the new network shows that deformation is localized in the vicinity of the Chalderan, south Gailatu-Siah Cheshmeh-Khoy fault and the North Tabriz fault. However the eastern end of the North Tabriz fault appears to cross Mount Bozgush rather than following its southern foothills. This new velocity field does not indicate the 8 mm/yr of NNE-SSW extension suggested earlier for the region, but rather shows lower extension of 1-2 +/- 1 mm/yr across the eastern segment of the North Tabriz fault and the Talesh. To the west, the Chalderan and the western North Tabriz fault segment act like pure strike slip faults without significant extension or compression. The denser network in the Rudbar earthquake region (Ms 7.3, 1992) shows no significant motion across the fault, suggesting that the recurrence time of earthquakes like the Rudbar event must be very long. The lack of substantial compressive strain and the sharp azimuth change of the velocity vectors in the transition zone from Arabia to Lesser Caucasus motion imply that processes other than "extrusion", possibly related to old subduction or delamination, contribute to active deformation.
ISSN: 0012-821X

hal-00617666
https://hal.archives-ouvertes.fr/hal-00617666
DOI : 10.1016/j.epsl.2011.04.029

Éditeur(s) : HAL CCSD
Résumé : Background Acute splenic sequestration is one of the major clinical forms of sickle cell disease. This potentially life-threatening complication is defined by a rapid sequestration of sickle red blood cells in the spleen. Approximately 30% of young patients will develop this complication and 49% of them will have recurrences. Methods The decision tree method is a statistical method that can act as a medical decision tool in the case of a complex biological problem. The decision tree method is used here to determine the variables involved in the severity and recurrence of acute splenic sequestration crises. Results A prior decision tree shows that platelet level, variation in spleen size, patient age and hygrometry also called relative humidity define acute splenic sequestration severity. A second one shows that spleen size variation, atmospheric pressure and patient age define recurrence. Conclusions For the first time, biological and environmental parameters are combined to discover some interesting rules which can lead to more accurate evaluations of acute splenic sequestration severity and recurrence. Thus, this method provides a sharp diagnostic tool which could improve medical treatment for better patient care.
https://hal.archives-ouvertes.fr/hal-00201460

hal-00201460
https://hal.archives-ouvertes.fr/hal-00201460
https://hal.archives-ouvertes.fr/hal-00201460v2/document
https://hal.archives-ouvertes.fr/hal-00201460/file/DT_Marianne_v2.pdf

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
BACKGROUND: Hepatocellular carcinoma (HCC) is a particularly severe disease characterized by a high rate of recurrence and death even after surgical resection. Molecular characterization of HCC helps refine prognosis and may facilitate the development of improved therapy. Phosphatidylinositol 4-kinases have recently been identified as cellular factors associated with cancer. Also, phosphatidylinositol 4-kinase type IIIα (PI4KA) is necessary for the propagation of the hepatitis C virus, a major etiological factor for HCC. METHODS: Reverse transcription, quantitative real-time PCR was used to assay PI4KA mRNA. The expression levels were investigated both in a collection of molecularly and clinically characterized hepatic tissues from 344 patients with diverse liver diseases and in human hepatocyte cell lines whose proliferative and differentiation status was controlled by specific culture conditions. Analytical microarray data for 60 HCC and six normal liver tissue samples were exploited to study correlations between PI4KA mRNA levels and cell proliferation markers in vivo. Postoperative disease-specific survival and time to recurrence in a set of 214 patients with HCC were studied by univariate and multivariate analyses. RESULTS: PI4KA mRNA was more abundant in HCC than normal healthy tissues. This upregulation correlated significantly with both poor differentiation and the active proliferation rate in HCC. These associations were confirmed with in vitro models. Moreover, patients with HCC who had been treated by surgical resection and had higher PI4KA mRNA concentrations in their tumor tissue exhibited a higher risk of tumor recurrence (median time: 20 months versus 49 months, P = 0.0012) and shorter disease-specific survival (first quartile time: 16 months versus 48 months, P = 0.0004). Finally, the abundance of PI4KA mRNA proved to be an independent prognostic marker of survival for cases of HCC (hazard ratio = 2.36, P = 0.0064). CONCLUSIONS: PI4KA mRNA could be used as a new molecular marker to improve established prognostic models for HCC. These findings also indicate possible new lines of research for the development of innovative therapeutic approaches targeting PI4KA.
ISSN: 1471-2407

inserm-00934294
http://www.hal.inserm.fr/inserm-00934294
http://www.hal.inserm.fr/inserm-00934294/document
http://www.hal.inserm.fr/inserm-00934294/file/1471-2407-14-7.pdf
DOI : 10.1186/1471-2407-14-7

Éditeur(s) : HAL CCSD American Geophysical Union
Résumé : International audience
Knowing the slip amplitudes that large earthquakes produced in prehistorical times is one key to anticipate the magnitude of large forthcoming events. It is long known that the morphology is preserving remnants of paleoearthquake slips in the form of fault-offset landforms. However, the measured offsets that can be attributed to the most recent paleoearthquakes are generally few along a fault, so that they rarely allow recovering the slip distributions and largest slips of these earthquakes. We acquired ~1 m resolution airborne lidar data on a 30 km stretch of a fast-slipping strike-slip fault (eastern Hope Fault, New Zealand) located in a region of high alluvial dynamics where landforms are rapidly evolving. Data analysis reveals >200 offset landforms; only 30% allow a good to moderate quality offset measurement. From these good to moderate quality measures, we recover the slip-length distributions and largest slips of the four most recent large paleoearthquakes and find evidence of 4–6 prior events. The record suggests that large earthquake slip recurred in multiples of about 4 m along the 30 km stretch. Although they have larger uncertainties, the more numerous lower-quality offsets that we also measured reveal a similar earthquake slip record. This shows that, although offset landforms are partly degraded in dynamically active landscapes, they store valuable information on paleoearthquake slips. This information might be recovered provided that the morphology is analyzed at high resolution and " continuously " over a significant fault length. Remote lidar data are powerful to perform such analyses.
ISSN: 2169-9313

insu-01469219
https://hal-insu.archives-ouvertes.fr/insu-01469219
https://hal-insu.archives-ouvertes.fr/insu-01469219/document
https://hal-insu.archives-ouvertes.fr/insu-01469219/file/Manighetti_et_al-2015-Journalsur Geophysical_Research__Solid_Earth.pdf
DOI : 10.1002/2014JB011787

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Aims: The aims of this study were to compare short-and long-term outcomes for clinical T2N0 oesophageal cancer with analysis of (i) primary surgery (S) versus neoadjuvant therapy plus surgery (NS), (ii) squamous cell carcinoma and adenocarcinoma subsets; and (iii) neoadjuvant chemoradiotherapy versus neoadjuvant chemotherapy.Methods: Data were collected from 30 European centres from 2000 to 2010. Among 2944 included patients, 355 patients (12.1%) had cT2N0 disease; 285 (S) and 70 (NS), were compared in terms of short-and long-term outcomes. Propensity score matching analyses were used to compensate for differences in baseline characteristics.Results: No significant differences between the groups were shown in terms of in hospital morbidity and mortality. Nodal disease was observed in 50% of S-group at the time of surgery, with 20% pN2/N3. Utilisation of neoadjuvant therapy was associated with significant tumour downstaging as reflected by increases in pT0, pN0 and pTNM stage 0 disease, this effect was further enhanced with neoadjuvant chemoradiotherapy. After adjustment on propensity score and confounding factors, for all patients and subset analysis of squamous cell and adenocarcinoma, neoadjuvant therapy had no significant effect upon survival or recurrence (overall, loco-regional, distant or mixed) compared to surgery alone. There were no significant differences between neoadjuvant chemotherapy and chemoradiotherapy in short-or long-term outcomes.Conclusion: The results of this study suggest that a surgery alone treatment approach should be recommended as the primary treatment approach for cT2N0 oesophageal cancer despite 50% of patients having nodal disease at the time of surgery.
ISSN: 0959-8049

hal-01666517
https://hal.univ-lorraine.fr/hal-01666517
DOI : 10.1016/j.ejca.2015.11.024

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
Coral reefs are increasingly being altered by a myriad of anthropogenic activities and natural disturbances. Long-term studies offer unique opportunities to understand how multiple and recurrent disturbances can influence coral reef resilience and long-term dynamics. While the long-term dynamics of coral assemblages have been extensively documented, the long-term dynamics of coral reef fish assemblages have received less attention. Here, we describe the changes in fish assemblages on Tiahura reef, Moorea, from 1979 to 2011. During this 33-yr period, Tiahura was exposed to multiple disturbances (crown-of-thorns seastar outbreaks and cyclones) that caused recurrent declines and recoveries of coral cover and changes in the dominant coral genera. These shifts in coral composition were associated with long-term cascading effects on fish assemblages. The composition and trophic structure of fish assemblages continuously shifted without returning to their initial composition, whereas fish species richness remained stable, albeit with a small increase over time. We detected nonlinear responses of fish density when corals were most degraded. When coral cover dropped below 10 % following a severe crown-of-thorns sea star outbreak, the density of most fish trophic groups sharply decreased. Our study shows that historical contingency may potentially be an important but largely underestimated factor explaining the contemporary structure of reef fish assemblages and suggests that temporal stability in their structure and function should not necessarily be the target of management strategies that aim at increasing or maintaining coral reef resilience.
ISSN: 0722-4028

hal-01282725
https://hal-univ-perp.archives-ouvertes.fr/hal-01282725
DOI : 10.1007/s00338-015-1371-2

Résumé : Nous avons étudié les marqueurs hémorhéologiques, hématologiques et biochimiques chez des sujets drépanocytaires homozygotes SS (HbS/HbS) et hétérozygotes composites SC (HbS/HbC) dans deux cohortes, pédiatriques et adultes, de patients drépanocytaires, et ce, à travers 7 complications récurrentes de la drépanocytose : 2 appartenant au profil hémolytique (l’ulcère de jambes et la glomérulopathie) et 5 appartenant au phénotype visqueux/vaso-occlusif (l’hypertension artérielle, le syndrome thoracique aigu (STA), la crise vaso-occlusive (CVO), la rétinopathie et l’ostéonécrose). Nous avons montré que : 1) une viscosité sanguine et une déformabilité érythrocytaire élevées sont des facteurs de risques de CVO chez les enfants homozygotes ; 2) Une viscosité sanguine élevée est associée à une hypertension artérielle systémique relative chez des adultes SS ; 3) les enfants SC présente une fonction vasculaire mieux préservée que les enfants SS pour faire face à une augmentation de la viscosité sanguine ; 4) les patients adultes SS avec une ostéonécrose présentent une déformabilité érythrocytaire plus élevée que les patients sans ostéonécrose ; 5) une viscosité sanguine élevée est associée à la présence d’une rétinopathie chez les adultes SC mais pas chez les SS ; 6) les patients adultes SS présentant une glomérulopathie ont un taux d’hémolyse élevé, une déformabilité érythrocytaire réduite et des agrégats érythrocytaires très robustes ; 7) les patients adultes SS avec des ulcères de jambes récurrents ont un taux d’hémolyse accru et une déformabilité érythrocytaire réduite. De plus, nos travaux confirment que l’-thalassémie module les propriétés de déformabilité érythrocytaire, mais montrent pour la première fois qu’elle module aussi les propriétés d’agrégation érythrocytaire, et notamment la force des agrégats érythrocytaires. En conclusion, ces travaux permettent de préciser le rôle de la rhéologie sanguine dans un certain nombre de complications de la drépanocytose et d’enrichir le modèle préexistant divisant les complications de la drépanocytose selon 2 phénotypes : hémolytique versus visqueux/vaso-occlusif. Nous montrons pour la première fois que le phénotype hémolytique est caractérisé aussi par des anomalies de la rhéologie du globule rouge : rigidité accrue et agrégats érythrocytaire robustes.
Hemorheological, hemathological, and biochemical marquers of patients with sickle cell anemia (SS) and patients with sickle cell SC disease (SC) were studied in 2 cohorts: children and adults. We focused on 7 recurrent complications: 5 belonging to the viscosity/vaso-occlusion phenotype (systemic hypertension, acute chest syndrome (ACS), vaso-occlusive crisis (VOC), retinopathy and osteonecrosis) and 2 belonging to the hemolytic phenotype (leg ulcer and glomerulopathy). Our results show that 1) high viscosity is associated with increased risk for VOC in SS children; 2) blood viscosity is increased in SS adults with systemic relative hypertension; 3) SC children have preserved vascular function compared to SS children; 4) SS adults with osteonecrosis are characterized by higher red blood cell (RBC) deformability than SS adults without osteonecrosis; 5) high blood viscosity is associated with retinopathy in SC adults but not in SS adults; 6) SS adults affected by glomerulopathy have high hemolytic rate, low RBC deformability and increased RBC aggregates strenght; 7) SS adults with recurrent leg ulcers have high hemolytic rate and reduced RBC deformability. Moreover, our studies shows that alpha-thalassemia modulate RBC deformability and RBC aggregation properties. In conclusion, this work shows for the first time that the hemolytic phenotype is characterized by an abnormal RBC rheology which may play a role in several sickle cell complications.

http://www.theses.fr/2013AGUY0684/document

Éditeur(s) : Université de Bretagne Occidentale
Résumé : The negative impact of the man on the environment unquestionably increases. The coastal environment as a whole is the maritime environment which is the most exposed to man-made eutrophication. For instance, nitrate loads to coastal waters off Brittany (France) have increased 10 times (from 3 to s 30mg L-1NO3) during the four last decades. Eutrophication of this coastal zone is now a recurrent problem, more and more worrying. This eutrophication exhibits two main forms : " green tides ", which are caused by local proliferations and stranding of green macro-algae (particularly the Ulva species) in nitrogen-enriched areas ; phytoplanktonic blooms, which are responsible for coloured water events, toxic species can be present (Pseudo-Nitzschia, Alexandrium, Dinophysis), and induce banning of shellfish consumption. The objectives of this study are to assess the respective role of various rivers (especially the Loire and the Vilaine) in the eutrophication of the Brittany shelf ecosystem and test the impact of nitrogen enrichment in the triggering of Pseudo-Nitzchia toxicity. For these purposes, a coupled hydrodynamical/ biogeochemical 3D model has been developed and validated against past measured time-series and satellite images. After a brief analysis of primary production over the Brittany shelf under different conditions, we show a description of the real time adaptation of this model. Daily results are currently presented in real time on www.previmer.org web site. The inability of the model to correctly simulate near shore phytoplankton is worsened in this model by the fact that the turbidity field used is a climatological one, made by satellite images averaged on a decadal basis. First, near shore pixels of satellite images are scarcely reliable, secondly a climatological mean cannot represent the sudden bursts or drops of the real turbidity, highly dependent on the actual sea-state : this can explain also why the model at this moment fails to reproduce a sudden bloom occurring in a short period of sunny and calm weather. The simulated Pseudo-Nitzschia biomass and induced risk of toxicity in the water column cannot really be validated offshore, because monitoring measurements are available only near the coast, and deal only with toxicity in benthic filter feeders. To get temporarily rid of that problem, an interesting improvement would be to add to the operational model the bio-accumulation of toxin in the shellfishes : simulated concentrations in shellfish fresh would become directly comparable with usual measurements of the monitoring networks. Our model points out the important impact of Loire river loads on the primary production on the western and southern Brittany. This result is crucial for administrations in charge of reducing the terrestrial loadings responsible for eutrophication, because it can delay reduction programs on small tributaries until the main input from the Loire has been significantly reduced. A question arises, about the reliability of the haline stratification in the model, because the horizontal extent of the Loire plume will be enhanced by a stronger stratification.
L'eutrophisation des milieux marins côtiers, de plus en plus importante, représente un des impacts majeurs des activités humaines sur l'environnement. Les phénomènes d'eutrophisation sont en constante augmentation ; ces dernières décennies ont vu le nombre de sites touchés augmenter de par le monde. La bande côtière bretonne est particulièrement concernée par ce phénomène. L'eutrophisation s'y manifeste de deux façons : "Des phénomènes de marée vertes, très localisées, qui sont provoqués par la croissance excessive et l'échouage de macro-algues du genre Ulva dans ces zones riches en azote ; Des blooms de phytoplancton à l'origine des phénomènes d'eaux colorées, qui peuvent aussi provoquer des interdictions de consommation de coquillages lorsque les espèces mises en jeu sont toxiques (Pseudo-Nitzschia, Alexandrium, Dinophysis). L'objectif de ce travail est multiple : il vise à mettre en évidence et à comprendre l'impact et le rôle des apports en nutriments sur la production primaire et l'eutrophisation des milieux côtiers. Ce travail a aussi pour ambition l'identification et la compréhension des causes des phénomènes d'eutrophisation et permettre ainsi d'apporter des solutions ou des pistes d'amélioration. En n, il a aussi un objectif de prévision à court terme de l'état biologique sur la zone. Pour atteindre ces objectifs, un modèle en temps réel a été mis en oeuvre. Les résultats de simulations numériques et de mesures satellitaires sont présentés sur internet : www.previmer.org. L'outil principal de ce travail est un modèle couplé physique/biogéochimie. La partie hydrodynamique est fournie par le code Mars3D (3D hydrodynamical Model for Application at Regional Scale) développé à IFREMER. Au code hydrodynamique Mars3D est couplé le modèle des cycles de l'azote, du phosphore et du silicium d'IFREMER. Le modèle couplé permet de simuler en 3 dimensions et de manière dynamique les courants, le brassage horizontal et vertical, les champs de température et de salinité, mais aussi les principaux cycles de nutriments, reproduisant ainsi les conditions déterminantes de la production primaire. La croissance des algues est modélisée, et nous permet de voir l'influence des panaches de dilution des principales rivières bretonnes sur leur croissance. Les diffcultés du modèle à correctement simuler les concentrations en phytoplancton près des zones côtières, sont probablement dues à l'utilisation d'une climatologie de concentration en matière en suspension fondée sur des données satellitaires. Tout d'abord, les pixels côtiers des images satellitaires sont entachés d'erreurs, ensuite une climatologie n'est pas capable de représenter les apports soudains des fleuves lors des crues. Cela peut expliquer l'incapacité du modèle a représenter certains blooms liés à des périodes ensoleilées et calmes. A ce modèle de base nous avons ajouté un genre spécifique de phytoplancton : le genre Pseudo-Nitzschia. Certaines espèces de Pseudo-Nitzschia sont réputées toxiques. En effet, ce phytoplancton a la capacité de synthétiser une toxine : l'acide domoïque. Cette toxine est responsable du syndrome ASP (Amnesic Shellfish Poisoning). Le modèle reproduit globalement les mêmes zones de toxicité que les mesures du REPHY, et donne des résultats encourageants. L'étude montre que la Loire influence une large partie de la bande côtière bretonne ; son panache remonte jusqu'au nord de la mer d'Iroise, et contribue pour une grande part à l'enrichissement du sud et de l'ouest de la Bretagne. Le traçage de l'azote en provenance de la Loire au sein des cycles biogéochimiques nous a permis de quantifier cet enrichissement.

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/00015/12603/9481.pdf
http://archimer.ifremer.fr/doc/00015/12603/

Éditeur(s) : Springer
Résumé : Two recurring syndromes threaten the viability of the shrimp industry in New Caledonia, which represents the second largest export business. The "Syndrome 93" is a cold season disease due to Vibrio penaeicida affecting all shrimp farms, while the "Summer Syndrome" is a geographically restricted vibriosis caused by a virulent lineage of Vibrio nigripulchritudo. Microbiological procedures for diagnosis of these diseases are time-consuming and do not have the ability to discriminate the range of virulence potentials of V. nigripulchritudo. In this study, we developed a multiplex PCR method to simultaneously detect these two bacterial species and allow for pathotype discrimination. The detection limits of this assay, that includes an internal amplification control to eliminate any false-negative results, were determined at 10 pg purified DNA and 200 cfu/ml. After confirming the effectiveness of our method using experimentally infected animals, its accuracy was compared to standard biochemical methods during a field survey using 94 samples collected over 3 years from shrimp farms encountering mortality events. The multiplex PCR showed very high specificity for the detection of V. penaeicida and V. nigripulchritudo (inclusivity and exclusivity 100%) and allowed us to detect the spreading of highly pathogenic isolates of V. nigripulchritudo to a farm adjoining the "Summer Syndrome area." This assay represents a simple, rapid, and cost-effective diagnostic tool for implementing timely risk management decisions but also understanding the seasonal and geographical distribution of these pathogens.
Microbial Ecology (0095-3628) (Springer), 2012-01 , Vol. 63 , N. 1 , P. 127-138

Droits : Springer Science+Business Media, LLC 2011
http://archimer.ifremer.fr/doc/00063/17398/15169.pdf
DOI:10.1007/s00248-011-9951-3
http://archimer.ifremer.fr/doc/00063/17398/

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
We develop a block model for the Aegean and surrounding areas, constrained by Global Positioning System (GPS), in order to investigate the degree of coupling on the Hellenic subduction interface (i.e., the fraction of the motion across the plate boundary accommodated by elastic strain accumulation). We use previously published models, and seismicity to define the geometry of the interface separating the down-going Nubian slab from the overriding Aegean. This model provides a good fit to the GPS observations; for the ∼200,000 km2 Aegean block the wrms of the residual velocities is 1.4 mm/yr for 80 GPS velocity estimates, approximately the 95% level of the GPS velocity uncertainties. We investigate the degree of coupling on the seismically active plate interface, the Hellenic trench splay fault (believed to be the source of the 365 AD Great Crete Earthquake and Tsunami), and the Kephalonia transform fault by comparing the modeled GPS residual velocity field for a range of coupling values. The GPS observations are almost insensitive to coupling on the Kephalonia transform fault, because of the vertical dip of the fault that creates interseismic deformation only close to the fault where few GPS sites exist. The absence of resolvable shortening of the leading edge of the Aegean Plate precludes coupling of more than 0.2 (20% of the full Nubia-Aegean convergence rate) on the modeled plate interface. Because of the shallow dip of the plate interface and trench splay fault, and high rate of convergence, if these boundaries were fully coupled, high elastic strain rates would be expected to extend well into the overriding Aegean plate. Based on our preferred value for the degree of coupling (0.1), and assuming characteristic earthquake behavior, we estimate a recurrence time for great earthquakes with slip similar to that for the 365 Crete event of 5700-8300 yr, consistent with the absence of subsequent great earthquakes on this segment of the subduction zone.
ISSN: 0012-821X

hal-01053486
https://hal.archives-ouvertes.fr/hal-01053486
DOI : 10.1016/j.epsl.2013.10.018

Éditeur(s) : Université des Antilles Études caribéennes
Résumé : Cette étude s’attache à rendre compte des difficultés auxquelles l’île de La Réunion est confrontée de longue date et qui ne trouvent, jusqu’à présent, aucune issue satisfaisante en termes de développement. De crises en conflits, récurrents dans leurs formes comme dans leurs schémas spatiaux, La Réunion demeure enfermée dans des impasses multiples, économiques et sociétales. Aucune issue réelle ne se dessine : la confusion des responsabilités perdure et permet à des schémas éculés, présentés comme des innovations, de se reproduire sans fin.
This study aims to realize the difficulties that the island of Reunion is facing a long time and without satisfactory outcome in terms of development. Crises to conflicts, recurring forms, as in their spatial patterns, Reunion remains locked in an impasse multiple, economic and societal. No actual outcome does is emerging: the responsibilities confusion continues and allows worn patterns, presented as innovations, reproduced endlessly.
Réunion

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.4930
http://journals.openedition.org/etudescaribeennes/4930

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The Taiwan area, where the Philippine Sea Plate collides with Eurasia, is one of the most seismically active areas in the world and has been consequently struck repeatedly by destructive earthquakes. To better constrain the occurrence of large earthquakes, we have conducted two cruises in 2012 and 2013 from which five piston, gravity and box-cores were retrieved from selected sites in targeted areas that contain continuous and accurate turbidite deposition offshore eastern Taiwan. Forty-seven turbidite layers deposited between 675 BC and 2012 AD have been described in the cores with facies varying from silty clay to coarse sand. We modeled each turbidite layer using the sedimentation rate deduced from radiocarbon age measurements performed on planktonic foraminifers. Precise dating based on 210Pb–137Cs chronology provided ages for the XXth century turbidites. Coring sites' locations, biotic association within turbidites beds and seismic calibration over the instrumental period, suggest that earthquakes are the most likely triggering mechanisms of turbidity currents over the last 2700 years. Calibration of correlations between turbidites and instrumental earthquakes allowed us to determine the minimum magnitude of recorded events (Mw = 6.8) and the maximum distance between the epicenter and the slope failure. Turbidites' synchroneity between cores has been tested but results showed that this criterion cannot be used in our study area because of the high level of seismicity, i.e., a M > 6.8 earthquake recurrence interval much smaller than the uncertainty on radiocarbon ages. The excellent accuracy of dating allows correlating all the turbidites deposited since 1920 with instrumental earthquakes. For each core, we established a return time ranging between 112 and 147 years for the period pre-1900 and ~ 27 and 34 years for the period post-1900. The discrepancy between pre-1900 and post-1900 recurrence either suggests, that slope stability varies, with higher slope instability after 1900 possibly due to increased sediment delivery by rivers.
ISSN: 0040-1951

hal-01467627
https://hal.archives-ouvertes.fr/hal-01467627
DOI : 10.1016/j.tecto.2016.04.030

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
To estimate the seismic hazard, the geometry (dip, length and orientation) and the dynamics (type of displacements and amplitude) of the faults in the area of interest need to be understood. In this paper, in addition to geomorphologic observations, we present the results of two ground penetrating radar (GPR) campaigns conducted in 2010 and 2011 along the Emeelt fault in the vicinity of Ulaanbaatar, capital of Mongolia, located in an intracontinental region with low deformation rate that induces long recurrence time between large earthquakes. As the geomorphology induced by the fault activity has been highly smoothed by erosion processes since the last event, the fault location and geometry is difficult to determine precisely. However, by using GPR first, a non-destructive and fast investigation, the fault and the sedimentary deposits near the surface can be characterized and the results can be used for the choice of trench location. GPR was performed with a 50 MHz antenna over 2-D lines and with a 500 MHz antenna for pseudo-3-D surveys. The 500 MHz GPR profiles show a good consistency with the trench observations, dug next to the pseudo-3-D surveys. The 3-D 500 MHz GPR imaging of a palaeochannel crossed by the fault allowed us to estimate its lateral displacement to be about 2 m. This is consistent with a right lateral strike-slip displacement induced by an earthquake around magnitude 7 or several around magnitude 6. The 2-D 50 MHz profiles, recorded perpendicular to the fault, show a strong reflection dipping to the NE, which corresponds to the fault plane. Those profiles provided complementary information on the fault such as its location at shallow depth, its dip angle (from 23 • to 35 •) and define its lateral extension. Central Asia is known for its high level of seismic hazards, especially Mongolia, which has been one of the most seismically active intracontinental regions in the world with four large earthquakes (magnitude around 8) along its active faults in the western part of the country during the last century (Khilko et al. 1985). The deformation in Mongolia is located between compressive structures related to the collision and penetration of the Indian plate into the Eurasian plate and extensive structures in the north of the country related with the Baykal rift (Tapponnier & Molnar 1979; Baljinnyam et al. 1993; Schlupp 1996; Bayasgalan & Jackson 1999). The seismic activity observed in the vicinity of Ulaanbaatar (UB), capital of Mongolia, is relatively low compared to the activity observed in western Mongolia. Nevertheless, since 2005, the seismic activity around UB not only has increased, but is also organized (see Fig. 1) at the west of UB along two perpendicular directions, which determine two active faults: Emeelt fault, discovered in 2008 (NNW-SSE direction, 25-km-long minimum and situated about 10 km W of UB) and Hustai fault (WSW–ENE direction, 80 km long, with its NE tip at less than 20 km west of UB); their length and morphology indicate that they can produce earthquakes of magnitude 6.5–7.5 (Schlupp et al. 2012). Most of the Mongolian population (1.2 million over 3 million) is concentrated at UB, which is the main political and economical centre of the country. Hence, the study of seismic hazard and the estimation of the probability of future destructive earthquakes are of primary importance for the country (Dugarmaa et al. 2006). Since the last large earthquake, the faults geomorphology has been highly smoothed by erosional processes and the exact location of the fault plane surface rupture is thus hidden within a several metre wide strip. The GPR method has been proven to give good and useful results to characterize faults by identifying offsets of radar reflections (Malik et al. 2007; Christie et al. 2009; Yalçiner et al. 2013) and
ISSN: 0956-540X

hal-01342629
https://hal.archives-ouvertes.fr/hal-01342629
https://hal.archives-ouvertes.fr/hal-01342629/document
https://hal.archives-ouvertes.fr/hal-01342629/file/Dujardin_Bano_etal_Geoph.%20J.%20Int._2014_final.pdf
DOI : 10.1093/gji/ggu130

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
A relevant and accurate description of three-dimensional (3D) protein structures can be achieved by characterizing recurrent local structures. In a previous study, we developed a library of 120 3D structural prototypes encompassing all known 11-residues long local protein structures and ensuring a good quality of structural approximation. A local structure prediction method was also proposed. Here, overlapping properties of local protein structures in global ones are taken into account to characterize frequent local networks. At the same time, we propose a new long local structure prediction strategy which involves the use of evolutionary information coupled with Support Vector Machines (SVMs). Our prediction is evaluated by a stringent geometrical assessment. Every local structure prediction with a Calpha RMSD less than 2.5 A from the true local structure is considered as correct. A global prediction rate of 63.1% is then reached, corresponding to an improvement of 7.7 points compared with the previous strategy. In the same way, the prediction of 88.33% of the 120 structural classes is improved with 8.65% mean gain. 85.33% of proteins have better prediction results with a 9.43% average gain. An analysis of prediction rate per local network also supports the global improvement and gives insights into the potential of our method for predicting super local structures. Moreover, a confidence index for the direct estimation of prediction quality is proposed. Finally, our method is proved to be very competitive with cutting-edge strategies encompassing three categories of local structure predictions. Proteins 2009. (c) 2009 Wiley-Liss, Inc.
ISSN: 0887-3585

inserm-00348740
http://www.hal.inserm.fr/inserm-00348740
http://www.hal.inserm.fr/inserm-00348740/document
http://www.hal.inserm.fr/inserm-00348740/file/Bornot_Proteins_2009_preprint_version.pdf
http://www.hal.inserm.fr/inserm-00348740/file/inserm-00348740_edited.pdf

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Fromthe Proterozoic to the Quaternary, the evolution of the Earthwas characterised by recurrent periods of glaciation.However, the margins of many ancient ice-sheets are poorly defined on palaeogeographic reconstructions.The extent and outlines of ancient ice sheets can be better understood through careful documentation ofsediments deposited at the ice-sheet margin. An outstanding example is provided herein based on an end-Ordovician archive in Libya (Tihemboka area, Murzuq Basin). The four sets of structures include: i) subglacialglaciotectonic structures and soft sediment deformations from flowing glacier ice, such as intraformational glacialstriae, intraformational deformation (shear planes, sheath folds), normal microfaults, and large-scaleglaciotectonic folds-and-thrusts; (ii) structures resulting from overpressured subglacial (meltwater) flowssuch as clastic dykes and tunnel valleys; (iii) proglacial depositional structures and facies related to highmagnitudemeltwater floods such as sandstone intraclasts, large-scale bedforms resulting from supercriticalflows, climbing-dune cross-stratification and kettle holes; and (iv) deformation structures resulting from freefloating and nonglacier ice such as ice-keel scours and ice-crystal marks. Such a set of structures points to anice-marginal (essentially continental) depositional setting, and provides an excellent suite of criteria to identifymargins of ancient ice sheets in the stratigraphic record. At a regional scale, a reconstruction through time andspace of the related depositional wedge is proposed. This corresponded to a seismic-scale (N120 m in thickness,40 km in length) ice-marginal wedge in front of an essentially warm-based ice-sheet inducing concomitantlarge-scale glaciotectonic deformation, glacial basin and tunnel valley downcuttings. The related ice-front wasassociated with high-energy meltwater flows feeding a network of deeply incised proglacial channels downstreamand, beyond them, a fluvioglacial deltaic system. Shallow ice-marginal permafrost most likely affectedthe depositional wedge. At a larger scale, the Tihemboka ice-marginal wedge is interpreted as related to a stillstandperiod over the Gondwana platform, developed over an estimated interval of a few thousands of years.Based on these data, the conditions that arose in a particularly favourable context for the development, the preservationand the identification of ice-marginal wedges in the geological record are reviewed. Significantmeltwater-derived sediment deposition and aggradation in an accommodation space resulting either frompreglacial inheritance, glacial downcuttings and/or glacio-isostatic lithospheric flexure, or active tectonic subsidence(>1 Myr) are required for their formation and subsequent preservation.
ISSN: 0012-8252

insu-01184739
https://hal-insu.archives-ouvertes.fr/insu-01184739
DOI : 10.1016/j.earscirev.2015.06.006