Éditeur(s) : ISTPM
Revue des Travaux de l'Institut des Pêches Maritimes (0035-2276) (ISTPM), 1953-12 , Vol. 18 , N. 69 , P. 65-74

Droits : Ifremer
http://archimer.ifremer.fr/doc/1953/publication-6744.pdf
http://archimer.ifremer.fr/doc/00000/6744/

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Aims: The aims of this study were to compare short-and long-term outcomes for clinical T2N0 oesophageal cancer with analysis of (i) primary surgery (S) versus neoadjuvant therapy plus surgery (NS), (ii) squamous cell carcinoma and adenocarcinoma subsets; and (iii) neoadjuvant chemoradiotherapy versus neoadjuvant chemotherapy.Methods: Data were collected from 30 European centres from 2000 to 2010. Among 2944 included patients, 355 patients (12.1%) had cT2N0 disease; 285 (S) and 70 (NS), were compared in terms of short-and long-term outcomes. Propensity score matching analyses were used to compensate for differences in baseline characteristics.Results: No significant differences between the groups were shown in terms of in hospital morbidity and mortality. Nodal disease was observed in 50% of S-group at the time of surgery, with 20% pN2/N3. Utilisation of neoadjuvant therapy was associated with significant tumour downstaging as reflected by increases in pT0, pN0 and pTNM stage 0 disease, this effect was further enhanced with neoadjuvant chemoradiotherapy. After adjustment on propensity score and confounding factors, for all patients and subset analysis of squamous cell and adenocarcinoma, neoadjuvant therapy had no significant effect upon survival or recurrence (overall, loco-regional, distant or mixed) compared to surgery alone. There were no significant differences between neoadjuvant chemotherapy and chemoradiotherapy in short-or long-term outcomes.Conclusion: The results of this study suggest that a surgery alone treatment approach should be recommended as the primary treatment approach for cT2N0 oesophageal cancer despite 50% of patients having nodal disease at the time of surgery.
ISSN: 0959-8049

hal-01666517
https://hal.univ-lorraine.fr/hal-01666517
DOI : 10.1016/j.ejca.2015.11.024

Éditeur(s) : HAL CCSD Elsevier
Résumé : Une approche par datations multiples a été menée sur les dépôts de sédiments de crue retrouvés dans les gorges du Gardon (Languedoc). Le plomb-210, le césium-137 et l’analyse géochimique des sédiments contaminés par les mines ont été utilisés pour reconstruire l’histoire des dépôts de crue. Cette approche a été combinée avec l’historique des crues du Gardon depuis 1890 pour affiner l’approche géochronologique. Au niveau de la cavité GG et de la terrasse GE les analyses ont permis d’illustrer les mécanismes d’érosion-redéposition pouvant perturber les séquences de sédiments. Les enregistrements des dépôts de sédiments de crue sont complets sur la terrasse GE située à 10 m au-dessus du lit mineur à partir de 1958, et incomplets auparavant. Sur la période 1880-1958, 25 crues ont eu un débit suffisant (>1450 m3/s) pour recouvrir la terrasse, alors que l’on recense seulement 5 à 6 crues depuis 1958 (pour un débit de submersion supérieur à 1700 m3/s). L’augmentation progressive du débit de submersion et la fréquence moindre d’inondation de la terrasse ont pu permettre sur la période récente la stabilisation de la couche de surface par la végétation et limiter l’érosion lors de crues importantes. Les enregistrements semblent complets dans la cavité GG située à 15 m au-dessus du lit mineur. La fréquence moindre de submersion à ce niveau plus élevé peut expliquer une meilleure stabilisation des dépôts de crue, rendus moins vulnérables à l’érosion. La datation au radiocarbone a été testée même si elle ne permet pas de dater avec précision les dépôts de crue des derniers siècles. Sur la terrasse GE, 80% des dates au carbone 14 sur charbon de bois sont beaucoup trop vieilles par rapport aux autres techniques de datation, ce qui peut s’expliquer par une remobilisation/déstockage de charbons de bois anciens. Les datations radiocarbone sur graines donnent de meilleurs résultats, car issues d’une production annuelle, plus facilement décomposable et moins sujette à des dépôts intermédiaires. Au final, il apparaît que la technique de datation par radiocarbone sur des charbons de bois retrouvés dans les séquences sédimentaires n’est pas fiable, alors qu’elle est la plus pratiquée en paléo-hydrologie. L’utilisation combinée du plomb-210, du césium-137, de l’analyse géochimique des sédiments et des informations sur les crues historiques a permis de discriminer et de dater les différents dépôts de crue de ce dernier siècle dans la cavité GG et la terrasse GE. / A multidating approach was carried out on slackwater flood deposits, preserved in valley side rock cave and terrace, of the Gardon River in Languedoc, southeast France. Lead-210, caesium-137, and geochemical analysis of mining-contaminated slackwater flood sediments have been used to reconstruct the history of these flood deposits. These age controls were combined with the continuous record of Gardon flow since 1890, and the combined records were then used to assign ages to slackwater deposits. The stratigraphic records of terrace GE and cave GG were excellent examples to illustrate the effects of erosion/preservation in a context of a progressively self-censoring, vertically accreting sequence. The sedimentary flood record of the terrace GE located at 10 m above the channel bed is complete for years post-1958 but incomplete before. During the 78-year period 1880-1958, 25 floods of a sufficient magnitude (> 1450 m3/s) have covered the terrace. Since 1958, however, the frequency of inundation of the deposits has been lower:only 5 or 6 floods in 52 years have been large enough to exceed the necessary threshold discharge (> 1700 m3/s). The progressive increase of threshold discharge and the reduced frequency of inundation at the terrace could allow stabilisation of the vegetation cover and improved protection against erosion from subsequent large magnitude flood events. The sedimentary flood record seems complete for cave GG located at 15 m above the channel bed. Here, the low frequency of events would have enabled a high degree of stabilisation of the sedimentary flood record, rendering the deposits less susceptible to erosion. Radiocarbon dating are used in this study and compared to the other dating techniques.Eighty percent of radiocarbon dates on charcoals were considerably older than those obtained by the other techniques in the terrace. On the other hand, radiocarbon dating on seeds provided better results. This discrepancy between radiocarbon dates on charcoal and seeds is explained by the nature of the dated material (permanent wood vs. annual production and resistance to degradation process). Finally, we showed in this study that although the most common dating technique used in paleoflood hydrology is radiocarbon dating, usually on charcoal preserved within slackwater flood sediments, this method did not permitus to define a coherent age model. Only the combined use of lead-210, caesium-137, and geochemical analysis of mining-contaminated sediments with the instrumental flood record can be applied to discriminate and date the recent slackwater deposits of the terrace GE and cave GG.
ISSN: 0169-555X

hal-01059669
https://hal.archives-ouvertes.fr/hal-01059669
https://hal.archives-ouvertes.fr/hal-01059669/document
https://hal.archives-ouvertes.fr/hal-01059669/file/ly2014-pub00040953.pdf
IRSTEA : PUB00040953

Éditeur(s) : ISTPM
Résumé : Following a number of expeditions we have been in charge of (in 1949 in Reunion Island, - in spring 1950 in Madeira, Canaries and the Azores Islands, - in 1950- 1951 in Martinique and Guadeloupe, - at the beginning of the summer 1951 in the Azores Islands and on the Cantabrian coast, during the cruises of the "Président Théodore Tissier"), we got to study more specifically the Scombroid group, largely represented in the waters of the Mascareignes Islands, the Caribbean Sea and, closer to us, the Eastern Atlantic Ocean.
A la suite de différentes missions dont nous avons été chargé (en 1949 à l'île de la Réunion, - au printemps de 1950 à Madère, aux Canaries et aux Açores, - en 1950- 1951 à la Martinique et à la Guadeloupe, - au début de l'été 1951 aux Açores et sur la côte Cantabrique, lors des campagnes du navire océanographique «Président Théodore Tissier») nous avons été amené à étudier plus spécialement le groupe des Scombroïdes très largement représenté dans les eaux des îles Mascareignes, dans la Mer Caraïbe et, plus près de nous, dans l'Atlantique Oriental. [OCR NON CONTRÔLE]
Revue des Travaux de l'Institut des Pêches Maritimes (0035-2276) (ISTPM), 1953-12 , Vol. 18 , N. 69 , P. 35-63

Droits : Ifremer
http://archimer.ifremer.fr/doc/1953/publication-6743.pdf
http://archimer.ifremer.fr/doc/00000/6743/

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
A decreased global autonomic nervous system (ANS) activity and increased sympathetic activation in patients with sickle cell anemia (SCA) seem to worsen the clinical severity and could play a role in the pathophysiology of the disease, notably by triggering vaso-occlusive crises. Because exercise challenges the ANS activity in the general population, we sought to determine whether a short (,15 min) and progressive moderate exercise session conducted until the first ventilatory threshold had an effect on the ANS activity of a group of SCA patients and a group of healthy individuals (CONT group). Temporal and spectral analyses of the nocturnal heart rate variability were performed before and on the 3 nights following the exercise session. Standard deviation of all normal RR intervals (SDNN), total power, low frequencies (LF) and high frequencies powers (HF) were lower but LF/HF was higher in SCA patients than in the CONT group. Moderate exercise did not modify ANS activity in both groups. In addition, no adverse clinical events occurred during the entire protocol. These results imply that this kind of short and moderate exercise is not detrimental for SCA patients.
ISSN: 1932-6203

hal-01136725
https://hal.univ-antilles.fr/hal-01136725
https://hal.univ-antilles.fr/hal-01136725/document
https://hal.univ-antilles.fr/hal-01136725/file/Hedreville%20et%20al.%20-%202014%20-%20Acute%20moderate%20exercise%20does%20not%20further%20alter%20the%20autonomic%20nervous%20system%20activity%20in%20patients%20with%20sick%282%29.pdf
DOI : 10.1371/journal.pone.0095563

Éditeur(s) : HAL CCSD American Geophysical Union (AGU)
Résumé : International audience
[1] Zircons and monazites from 6 samples of the North Ayilari dextral shear zone (NAsz), part of the Karakorum fault zone (KFZ), have been dated with the U-Th-Pb method, using both ID-TIMS and SIMS techniques. The ages reveal (1) inheritance from several events spanning a long period between the late Archean and the Jurassic; (2) an Eocene-Oligocene magmatic event (similar to 35-32 Ma); (3) an Oligo-Miocene magmatic event (similar to 25-22 Ma), at least partly synkinematic to the right-lateral deformation; and (4) a period of metamorphism metasomatism (similar to 22-14 Ma) interpreted as thermal and fluid advection in the shear zone. The Labhar Kangri granite located similar to 375 km farther Southeast along the KFZ is dated at 21.1 +/- 0.3 Ma. Such occurrence of several Oligo-Miocene granites along the KFZ, some of which show evidence for synkinematic emplacement, suggests that the fault zone played an important role in the genesis and /or collection of crustal melts. We discuss several scenarios for the onset and propagation of the KFZ, and offset estimates based on the main sutures zones. Our preferred scenario is an Oligo-Miocene initiation of the fault close to the NA range, and propagation along most of its length prior to similar to 19 Ma. In its southern half, the averaged long-term fault-rate of the KFZ is greater than 8 to 10 mm/a, in good agreement with some shorter-term estimates based on the Indus river course, or Quaternary moraines and geodesy. Our results show the KFZ cannot be considered as a small transient fault but played a major role in the collision history.
ISSN: 0278-7407

hal-00412570
https://hal.archives-ouvertes.fr/hal-00412570
DOI : 10.1029/2007TC002184

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Field evidence for syn-deformation migmatization and crystallization along the Karakorum fault contradicts the study of Wang et al. (2012). The ages of such magmatic rocks provide minimum ages for the onset of deformation at similar to 23 Ma in North Ayilari and similar to 19 Ma in Tangtse. The onset of deformation at 12 Ma in the Ayilari range inferred by Wang et al. (2012) from a muscovite Ar/Ar age is a cooling age, thus only a minimum age. The similar to 60 Ma granodiorite bodies, the ophiolitic rocks and the south Kailash thrust that are correlated across the fault to provide a 52 +/- 2 km finite offset do not define reliable piercing points. Such observations as well as our previous work concur to show that the Karakorum fault initiated in the Oligo-Miocene, and has a long-term dextral slip-rate between 7.5 and 13 mm/yr, approximately twice that proposed by Wang et al. (2012).
ISSN: 0012-821X

hal-00829469
https://hal.archives-ouvertes.fr/hal-00829469
DOI : 10.1016/j.epsl.2012.12.012

Éditeur(s) : HAL CCSD EDP Sciences
Résumé : International audience
This paper presents a paleo-hydrological study conducted on sediment flood deposits at two sites located in the Gardon Gorges, Southeast France. The first study site is a valley‑side terrace (referred to as site GE, located 10m above the channel bed) and the second is located in a cave (referred to as site GG, perched 15m above the bed level). Paleo‑flood events were identified by carefully analyzing each slackwater flood deposits. The flood units were then dated using a variety of dating techniques, namely 137Cs, 210Pbex, 14C geochemical analysis of mining‑contaminated slackwater flood sediments, archeological objects and the historic flood record. Hydraulic modeling was also carried out in order to verify the coherence between the stratigraphic records of flood deposits at the sites and the historic flood levels known along the river Gardon. It is demonstrated that all the major flood events of the 20th century can be identified at terrace GE. This type of geomorphological unit can therefore be used as a sound basis for a paleo-hydrological analysis of the Gardon Gorges. Furthermore, the analysis of the stratigraphic record at site GG demonstrates that the site can be used to trace the largest flood events that have occurred within the past 600 years. The study reveals that the frequency of extreme flood events increased during the Little Ice Age
Une étude paléo-hydrologique a été entreprise dans les Gorges du Gardon, où deux coupes sédimentaires ont été étudiées. La première provient d'une terrasse (coupe GE située à 10 m de hauteur au dessus de la rivière) et l'autre, d'une cavité (coupe GG localisée à 15 m au-dessus de la rivière). L'identification et la mise en évidence des différents paléo-événements de crue ont été établies grâce à l'inspection minutieuse de chaque dépôt sédimentaire et d'une étude géochronologique fine (137Cs, 210Pbex, 14C, métaux traces, objets archéologiques, historiques des crues). Nous avons souhaité évaluer la capacité des terrasses fluviatiles du Gardon à enregistrer des paléo-événements en comparant les coupes sédimentaires aux données historiques des hauteurs d'eau et aux résultats d'un modèle hydraulique 1D. Nous montrons que la terrasse GE enregistre la quasi-totalité des évènements du 20ème siècle et qu'à priori, ce type d'objet géomorphologique peut être utilisé pour toute étude paléo-hydrologique sur le Gardon. De plus, l'étude de la coupe GG (cavité perchée à 15 m) permet de reconstituer les évènements intenses au cours des 600 dernières années. Nous montrons une augmentation des crues extrêmes dans le Haut-Languedoc au cours du "Petit âge glaciaire".
ISSN: 0018-6368

hal-01108400
https://hal.archives-ouvertes.fr/hal-01108400
https://hal.archives-ouvertes.fr/hal-01108400/document
https://hal.archives-ouvertes.fr/hal-01108400/file/ly2014-pub00041935.pdf
DOI : 10.1051/lhb/2014037

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Field study, thermochronology and geochemistry of the east Lungmu Co (LMC) range highlight some of the geological events that shaped western Tibet. The LMC fault zone has long been interpreted as the boundary between the Tianshuihai terrane of Laurasian affinity and the Qiangtang block of Gondwanian affinity. In the LMC range, the Paleozoic series is intruded by the Mangtsa leucogranite whose zircon have a U/Pb age of 116.9 ± 1 Ma and by mafic rocks with U/Pb zircon ages ranging from 116.9 ± 1 to 95.1 ± 1.7 Ma. Geochemistry of the mafic rocks indicates that they have been emplaced in a supra-subduction zone setting, probably the north dipping Nujiang suture zone. 40Ar/39Ar micas ages of the granite indicate that cooling below ~ 350 °C occurred between 105 and 85 Ma. 40Ar/39Ar K-feldspar data suggest a fast cooling event at 60-55 Ma, which we relate to the reactivation of the LMC suture zone as a thrust at the onset of the India-Eurasia collision. The last, and still active, deformation event corresponds to left-lateral strike-slip faulting along the ENE-WSW LMC fault.
ISSN: 1342-937X

hal-00660491
https://hal.archives-ouvertes.fr/hal-00660491
DOI : 10.1016/j.gr.2011.07.026

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
A dense, local network of 30 geodetic markers covering a 50 × 60 km2 area in the southwestern European Alps (Briançon region) has been temporarily surveyed in 1996, 2006 and 2011 by GPS. The aim is to measure the current deformation in this seismically active area. The study zone is characterized by a majority of extensional and dextral focal mechanisms, along north–south to N160 oriented faults. The combined analysis of the three measurement campaigns over 15 years and up to 16 years of permanent GPS data from the French RENAG network now enables to assess horizontal velocities below 1 mm/year within the local network. The long observation interval and the redundancy of the dense campaign network measurement help to constrain a significant local deformation pattern in the Briançon region, yielding an average E–W extension of 16 ± 11 nanostrain/year. We compare the geodetic deformation field to the seismic deformation rate cumulated over 37 years, and obtain good coherencies both in amplitude and direction. Moreover, the horizontal deformation localized in the Briançon region represents a major part of the Adriatic-European relative plate motion. However, the average uplift of the network in an extensional setting needs the presence of buoyancy forces in addition to plate tectonics.
ISSN: 0264-3707

hal-01119724
https://hal.archives-ouvertes.fr/hal-01119724
DOI : 10.1016/j.jog.2015.02.001

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
We report chlorine (Cl) and fluorine (F) abundances in minerals, interstitial glasses, and melt inclusions in 12 andesite-hosted, spinel harzburgite xenoliths and crosscutting pyroxenite veins exhumed from the sub-arc lithospheric mantle beneath Avacha volcano in the Kamchatka Arc (NE Russia). The data are used to calculate equilibrium mineral-melt partition coefficients (Dmineral/meltDmineral/melt) for Cl and F relevant to subduction-zone processes and unravel the history of volatile depletion and enrichment mechanisms in an arc setting.Chlorine is ∼100 times more incompatible in pyroxenes (View the MathML sourceDClmineral/melt = 0.005–0.008 [±0.002–0.003]) than F (View the MathML sourceDFmineral/melt = 0.50–0.57 [±0.21–0.24]), which indicates that partial melting of mantle sources leads to strong depletions in Cl relative to F in the residues. The data set in this study suggests a strong control of melt composition on View the MathML sourceDCl,Fpyroxene/melt, in particular H2O contents and Al/(Al + Si), which is in line with recent experiments. Fluorine is compatible in Ca-amphibole in the ‘wet’ sub-arc mantle (View the MathML sourceDFamphibole/melt = 3.5–3.7 [±1.5]) but not Cl (View the MathML sourceDClamphibole/melt = 0.03–0.05 [±0.01–0.03]), indicating that amphibole may fractionate F from Cl in the mantle wedge. The inter-mineral partition coefficients for Cl and F in this study are consistent amongst different harzburgite samples, whether they contain glass or not. In particular, disseminated amphibole hosts much of the Cl and F bulk rock budgets of spinel harzburgites (View the MathML sourceDClamphibole/pyroxene up to 14 and View the MathML sourceDFamphibole/pyroxene up to 40). Chlorine and fluorine are variably enriched (up to 1500 ppm Cl and 750 ppm F) in the parental arc picrite and boninite melts of primitive pyroxenite veins (and related melt inclusions) crosscutting spinel harzburgites.Based on the data in this study, the main inferences on the behaviour of Cl and F during melting and metasomatic processes in the sub-arc mantle are as follow:(i) Melting models show that most depleted mantle protoliths of intra-oceanic arc sources can have extremely low Cl/F (0.002–0.007) before being overprinted by subduction-derived components.(ii) Chlorine has a higher percolation distance in the mantle than F. Even for small fluid or melt volumes, Cl and F signatures of partial melting are overprinted by those of pervasive percolation, which increases Cl/F in percolating agents and bulk peridotites during chromatographic interaction and/or amphibole-forming metasomatic reactions. These processes ultimately control the bulk Cl and F compositions of the residual mantle lithosphere beneath arcs, and likely in other tectonic settings.(iii) Fluxed melting models suggest that Cl enrichment in arc picrite and boninite melts in this study, and in many arc melt inclusions reported in the literature, could be related to the infiltration of high Cl/F fluids derived from subducted serpentinite or altered crust in mantle wedge sources. However, these high Cl/F signatures should be re-evaluated with new models in light of the possible overprint of pervasive percolation effects in the mantle. The breakdown of amphibole (and/or mica) in the deep metasomatised mantle at higher pressure and temperature conditions than in the slab may explain, at least in part, the positive correlations between F abundances and Cl/F in primitive arc melt inclusions and slab depth.
ISSN: 0016-7037

hal-01553610
https://hal.archives-ouvertes.fr/hal-01553610
DOI : 10.1016/j.gca.2016.10.035

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : International audience
ISSN: 0168-1923

hal-01086595
https://hal-agroparistech.archives-ouvertes.fr/hal-01086595
DOI : 10.1016/j.agrformet.2009.06.020

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The present study investigated cerebral and muscle hemoglobin oxygen saturation (tissue oxygen index, TOI) in children with sickle cell anemia (SS), sickle cell hemoglobin C disease (SC) and healthy children (AA). TOI was measured by near-infrared spectroscopy (NIRS) and spectral analysis of the TOI variability was used to assess flowmotion and vasomotion. Arterial oxyhemoglobin saturation (SpO2), hemorheological and hematological parameters were also measured in SS and SC children. Both TOI were lower in SS compared to both AA and SC children, with SC exhibiting lower values than AA children. Cerebral vasomotion expressed in absolute values was enhanced in SS compared to AA and SC children. Muscle vasomotion did not differ between the three groups. Hematocrit, SpO2 and red blood cell deformability were positively associated with cerebral TOI in SS children. We demonstrated that 1) cerebral and muscle TOI were markedly decreased in SS children while the decrease of TOI was milder in SC children, 2) cerebral TOI level was associated with several biological markers in SS children only and 3) cerebral vasomotion was enhanced in SS, possibly to counterbalance the effects of chronic cerebral hypoxia.
ISSN: 1079-9796

inserm-01519106
http://www.hal.inserm.fr/inserm-01519106
http://www.hal.inserm.fr/inserm-01519106/document
http://www.hal.inserm.fr/inserm-01519106/file/2017%2C%20Charlot%20-%20Cerebral%20and%20muscle%20microvascular%20oxygenation%20in%20children%20with%20sickle%20celle%20disease.pdf
DOI : 10.1016/j.bcmd.2017.03.015