Éditeur(s) : DIREN : Direction Régionale de l'Environnement Université des Antilles et de la Guyane DIREN : Direction Régionale de l'Environnement Université des Antilles et de la Guyane

Droits : Document protégé par le droit d'auteur
fichiers:HASH01ca09b436a1cb186bb66245

Éditeur(s) : DIREN : Direction Régionale de l'Environnement Université des Antilles et de la Guyane DIREN : Direction Régionale de l'Environnement Université des Antilles et de la Guyane
Extrait de : Conférence Internationale "Biodiversité terrestre des Petites Antilles", 8-10 novembre 2010. Université des Antilles et de la Guyane, Faculté des Lettres et sciences humaines, campus de Schoelcher, Martinique.

Droits : CC-BY-NC-ND - Attribution - Pas d'utilisation commerciale - Pas de modification
Provenance : Université des Antilles et de la Guyane. Service commun de la documentation
Permalien : http://www.manioc.org/fichiers/HASH01ca09b436a1cb186bb66245
HASH01ca09b436a1cb186bb66245

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
Background: HCV treatment uptake has drastically increased in HIV-HCV coinfected patients in France since direct-acting antiviral (DAA) treatment approval, resulting in HCV cure in 63% of all HIV-HCV patients by the end of 2015. We investigated the impact of scaling-up DAA on HCV prevalence in the whole HIV population and in various risk groups over the next 10 years in France using a transmission dynamic compartmental model.Methods: The model was based on epidemiological data from the French Dat’AIDS cohort. Eight risk groups wereconsidered, including high-risk (HR) and low-risk (LR) men who have sex with men (MSM) and male/female heterosexuals,intra-venous drug users, or patients from other risk groups. The model was calibrated on prevalence and incidence dataobserved in the cohort between 2012 and 2015.Results: On January 1, 2016, 156,811 patients were registered as infected with HIV in France (24,900 undiagnosedpatients) of whom 7938 (5.1%) had detectable HCV-RNA (722 undiagnosed patients). Assuming a treatmentcoverage (TC) rate of 30%/year (i.e., the observed rate in 2015), model projections showed that HCV prevalenceamong HIV patients is expected to drop to 0.81% in 2026. Sub-analyses showed a similar decrease of HIV-HCVprevalence in most risk groups, including LR MSM. Due to higher infection and reinfection rates, predicted prevalencein HR MSM remained stable from 6.96% in 2016 to 6.34% in 2026. Increasing annual TC rate in HR MSM to 50/70%would decrease HCV prevalence in this group to 2.35/1.25% in 2026. With a 30% TC rate, undiagnosed patients wouldaccount for 34% of HCV infections in 2026.Conclusions: Our model suggests that DAA could nearly eliminate coinfection in France within 10 years for most riskgroups, including LR MSM. Elimination in HR MSM will require increased TC.
ISSN: 1741-7015

Droits : info:eu-repo/semantics/OpenAccess
inserm-01685739
http://www.hal.inserm.fr/inserm-01685739
http://www.hal.inserm.fr/inserm-01685739/document
http://www.hal.inserm.fr/inserm-01685739/file/2017%2C%20Virlogeux%20-%20Modeling%20HIV-HCV%20coinfection.pdf
DOI : 10.1186/s12916-017-0979-1

Éditeur(s) : HAL CCSD
Résumé : International audience
o abstract
Revue Des Maladies Respiratoires

hal-01647782
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01647782
DOI : 10.1016/j.rmr.2017.07.017
PUBMED : 28939155

Éditeur(s) : HAL CCSD
Résumé : International audience
o abstract
Revue Des Maladies Respiratoires

hal-01647076
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01647076
DOI : 10.1016/j.rmr.2017.07.022
PUBMED : 28935495

Éditeur(s) : HAL CCSD
Résumé : International audience
o abstract
Revue Des Maladies Respiratoires

hal-01647079
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01647079
DOI : 10.1016/j.rmr.2017.07.019
PUBMED : 28939154

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
In this study we attempt to understand the water storage variations in a karst aquifer on the Larzac Plateau (South of France) using ground-based gravimetry. Surface to 60 m depth gravity measurements are performed three times a year since 2006 down a pothole, in complement to monthly absolute gravity (AG) measurements at three sites. The time variations of the surface to depth (STD) gravity differences are compared with the AG variations. Using a simple Bouguer plate model, we find that the STD gravity differences are very similar to the AG variations. The STD gravity differences are then used to determine apparent density values. These integrative density values are compared with measured grain densities from core samples to obtain an apparent porosity and saturation change representative of the investigated depth. The apparent porosity ranges from 4.8 to 7.3 per cent. We then discuss on the repartition of the apparent physical properties with respect to the epikarst and infiltration zone karst structures. We argue that AG and STD differences monitor epikarst water storage variations. Within this scope, we discuss the fact that seasonal scale water storage variation occurs predominantly in the epikarst.
ISSN: 0956-540X

hal-00413528
https://hal.archives-ouvertes.fr/hal-00413528
DOI : 10.1111/j.1365-246X.2009.04118.x