Éditeur(s) : HAL CCSD
Résumé : 27 pages
Cascade Stochastic Differential Equation (SDE), a continuous time model for energy dissipation in turbulence, is a generalization of the Yaglom discrete cascade model. We extend this SDE to a model in random environment by assuming that its two parameters are switched by a continuous time Markov chain whose states represent the states of the environment. Moreover, a Dirichlet process is placed as a prior on the space of sample paths of this chain. We propose a Bayesian estimation method of this model which is tested both on simulated data and on real data of wind speed measured at the entrance of the mangrove ecosystem in Guadeloupe.
https://hal.archives-ouvertes.fr/hal-00286131

hal-00286131
https://hal.archives-ouvertes.fr/hal-00286131
https://hal.archives-ouvertes.fr/hal-00286131/document
https://hal.archives-ouvertes.fr/hal-00286131/file/Srik11_PhysicaDDspace.pdf

Éditeur(s) : HAL CCSD Taylor & Francis (Routledge)
Résumé : International audience
Border areas are particular “hot spots” generating high levels of HIV vulnerability and facing great challenges to control epidemics. The objective of this study is to describe the sociodemographic, clinical and biological profiles of newly HIV diagnosed people at the French Guiana - Suriname border, to construct an HIV care cascade and compare it with the Surinamese one. HIV-patients aged over 15 years newly diagnosed in western French Guiana in 2011 and 2012 were included in a retrospective cohort study. Patients were identified using different sources (n=121). The male-to-female ratio was 0.8, 85% of the patients were of foreign origin, 72% were undocumented migrants, 21% were living in Suriname and 48% had baseline CD4 cell counts <200 cells/mm3. After one year, 34% were lost to follow-up, 54% received treatment, 34% had controlled viremia and 6% died. We observed a disappointing HIV cascade, like that of Suriname, requiring to develop a coordinated healthcare offer on both sides of the border. Targeted efforts through a bi-national collaboration are needed to address the specific issues of cross-border patients to reach the 90*3 UNAIDS’s diagnosis, link to care and treatment targets and better control the local epidemic
ISSN: 0954-0121

inserm-01476267
http://www.hal.inserm.fr/inserm-01476267
http://www.hal.inserm.fr/inserm-01476267/document
http://www.hal.inserm.fr/inserm-01476267/file/2017%20Jaries%20-%20Population%20movements%20and%20the%20HIV%20cascade-1.pdf
DOI : 10.1080/09540121.2017.1291899

Éditeur(s) : Archives départementales de la Martinique
9Fi144
Fort-de-France
Centre ville (Fort-de-France)
Cascade de Gueydon (Fort-de-France)

Droits : Reproduction soumise à autorisation
http://www.patrimoines-martinique.org/ark:/35569/a0112730602545d35Ku

Éditeur(s) : Archives départementales de la Martinique
2Fi1121
Cascade d'Absalon (Fort-de-France)
Absalon (Fort-de-France)
Environs (Fort-de-France)
Fort-de-France

Droits : Reproduction soumise à autorisation
http://www.patrimoines-martinique.org/ark:/35569/a011273060190Mh25of

Éditeur(s) : Archives départementales de la Martinique
26Fi3/7
Saint-Pierre
Jardin des plantes (Saint-Pierre)

Droits : Reproduction soumise à autorisation
http://www.patrimoines-martinique.org/ark:/35569/a011414747009p05jm9

Éditeur(s) : Elsevier Science Inc
Résumé : The sex-determining system of Crassostrea gigas is still poorly known, especially regarding the potential influence of temperature. In order to address this question, mRNA expressions of actors of the molecular cascade (Cg-DMI, Cg-SoxE, Cg-beta-catenin, Cg-Foxl2/Cg-FoxI2os) and of Oyvlg, a germ cell marker, were investigated by real-time PCR in spat grown at different temperatures (18, 22, 25 and 28 degrees C). In parallel, gonadic differentiation, gametogenesis and sex ratios were assessed by histology at each of these temperatures. Whatever the temperature, Cg-DMI, Cg-SoxE, Cg-beta-catenin and Oyvlg expressions peaked at the same developmental stage, always after Cg-Foxl2/Cg-Foxl2os (around 40-44 dpf for spat grown at 18 degrees C). Temperatures increased the kinetics of first gonadic differentiation and gametogenesis. At 25 degrees C a significant switch occurred in sex ratio towards males and in the balance of expression between male and female genes, in favor of males. A slight gametogenesis disturbance was also observed. These results strengthen the hypotheses about the sex-determining time window and molecular cascade governing the development of C gigas, with notably the involvement of Cg-Foxl2/Cg-Foxl2os in the very early steps. They also suggest an influence of temperature on the oyster's sex determination which, associated to genetic control, would induce a mixed sex determination system (GSD +TSD). (C) 2013 Elsevier Inc. All rights reserved.
Comparative Biochemistry And Physiology A-molecular & Integrative Physiology (1095-6433) (Elsevier Science Inc), 2013-05 , Vol. 165 , N. 1 , P. 61-69

Droits : 2013 Elsevier Inc. All rights reserved
http://archimer.ifremer.fr/doc/00136/24767/22874.pdf
DOI:10.1016/j.cbpa.2013.02.007
http://archimer.ifremer.fr/doc/00136/24767/

Éditeur(s) : Archives départementales de la Martinique
21Fi6/59
Absalon (Fort-de-France)
Environs (Fort-de-France)
Fort-de-France

Droits : Reproduction soumise à autorisation
http://www.patrimoines-martinique.org/ark:/35569/a011273060472pFg5YC

Éditeur(s) : Archives de la Martinique
15Fi6
Lamentin (Le)
Rivière Lézarde

Droits : Reproduction soumise à autorisation des Archives de la Martinique
http://www.patrimoines-martinique.org/ark:/35569/a011470672738lojjzl

Éditeur(s) : Archives départementales de la Martinique
2Fi2533
Fort-de-France
Absalon (Fort-de-France)

Droits : Reproduction soumise à autorisation
http://www.patrimoines-martinique.org/ark:/35569/a011414681885za6dFv

Éditeur(s) : Archives départementales de la Martinique
34Fi84
Cascade de l'Alma (Fort-de-France)
Environs (Fort-de-France)
Fort-de-France
Alma (Fort-de-France)

Droits : Reproduction soumise à autorisation
http://www.patrimoines-martinique.org/ark:/35569/a011273060777gNBXCU

Éditeur(s) : Archives départementales de la Martinique
34Fi83
Pitons du Carbet
Cascade de l'Alma (Fort-de-France)
Environs (Fort-de-France)
Fort-de-France
Alma (Fort-de-France)

Droits : Reproduction soumise à autorisation
http://www.patrimoines-martinique.org/ark:/35569/a01127306077653Xfzi

Éditeur(s) : HAL CCSD
Résumé : International audience
Primary cultures of hepatocytes are powerful models in studying the sequence of events that are necessary for cell progression from a G0-like state to S phase. The models mimic the physiological process of hepatic regeneration after liver injury or partial hepatectomy. Many reports suggest that the mitogen-activated protein kinase (MAPK) ERK1/2 can support hepatocyte proliferation in vitro and in vivo and the MEK/ERK cascade acts as an essential element in hepatocyte responses induced by the EGF. Moreover, its disregulation has been associated with the promotion of tumor cell growth of a variety of tumors, including hepatocellular carcinoma. Whereas the strict specificity of action of ERK1 and ERK2 is still debated, the MAPKs may have specific biological functions under certain contexts and according to the differentiation status of the cells, notably hepatocytes. In this paper, we will focus on MEK1/2-ERK1/2 activations and roles in normal rodent hepatocytes in vitro and in vivo after partial hepatectomy and in human hepatocarcinoma cells. The possible specificity of ERK1 and ERK2 in normal and transformed hepatocyte will be discussed in regard to other differentiated and undifferentiated cellular models.
International Journal of Hepatology

Droits : info:eu-repo/semantics/OpenAccess
hal-00875664
https://hal.archives-ouvertes.fr/hal-00875664
https://hal.archives-ouvertes.fr/hal-00875664/document
https://hal.archives-ouvertes.fr/hal-00875664/file/TheMAPKMEK12-accepted.pdf
DOI : 10.1155/2012/328372

Éditeur(s) : HAL CCSD
Résumé : International audience
The most active deep convection area in the western Mediterranean Sea is located in the Gulf of Lions. Recent studies in this area provides some insights on the complexity of the physical dynamics of convective regions, but very little is known about their impacts on the biogeochemical properties. The CASCADE (CAscading, Surge, Convection, Advection and Downwelling Events) cruise, planed in winter 2011, give us the opportunity to compare vertical profiles of properties sampled either during stratified conditions or after/during a convection event. In the present study, we focus on the distributions of the carbonate system properties (mainly total alkalinity, AT; and total dissolved inorganic carbon, CT) because, in the context of the climate change, deep convection areas are suspected to significantly increase the sequestration of anthropogenic CO2 (CANT). Given its limited size, the impact of the Mediterranean Sea on the global carbon budget is probably minor but this marginal sea can be used as a laboratory to better understand carbon sequestration and its transfer to the basin interior by deep convection processes. Distributions of AT and CT, both measured from bottle samples, and that of CANT (estimated with the TrOCA approach) are first analyzed in the light of other key properties (salinity, temperature, and dissolved oxygen). An objective interpolation procedure is then applied to estimate CT and AT from CTD measured properties. With this procedure, the vertical resolution goes from a maximum of 32 samples per station to one property estimate every meter (more detailed distributions are obtained). Results provide arguments to conclude that CANT is rapidly transferred to the deepest layer due to deep convection events. During deep convection events, the increase of CANT in the water column is positively correlated to that of potential density and oxygen content. The challenge of quantifying the amount of sequestered carbon is however not resolved due to the complexity and the highly dynamical nature of the convective regions. Deep convection in the Gulf of Lions, in parallel with cascading along the continental slope, could thus potentially explain the very high levels of both CANT and acidification estimated in the deep layers of the western Mediterranean Sea.
Deep Sea Research Part I: Oceanographic Research Papers

hal-01336725
https://hal-univ-perp.archives-ouvertes.fr/hal-01336725
DOI : 10.1016/j.dsr.2016.04.003

Éditeur(s) : HAL CCSD
Résumé : International audience
Smoking is well-known to impair pharmacokinetics, through inducing expression of drug metabolizing enzymes. In the present study, we demonstrated that cigarette smoke condensate (CSC) also alters activity and expression of hepatic drug transporters, which are now recognized as major actors of hepatobiliary elimination of drugs. CSC thus directly inhibited activities of sinusoidal transporters such as OATP1B1, OATP1B3, OCT1 and NTCP as well as those of canalicular transporters like P-glycoprotein, MRP2, BCRP and MATE1, in hepatic transporters-overexpressing cells. CSC similarly counteracted constitutive OATP, NTCP and OCT1 activities in human highly-differentiated hepatic HepaRG cells. In parallel, CSC induced expression of BCRP at both mRNA and protein level in HepaRG cells, whereas it concomitantly repressed mRNA expression of various transporters, including OATP1B1, OATP2B1, OAT2, NTCP, OCT1 and BSEP, and enhanced that of MRP4. Such changes in transporter gene expression were found to be highly correlated to those caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin, a reference activator of the aryl hydrocarbon receptor (AhR) pathway, and were counteracted, for some of them, by siRNA-mediated AhR silencing. This suggests that CSC alters hepatic drug transporter levels via activation of the AhR cascade. Importantly, drug transporter expression regulations as well as some transporter activity inhibitions occurred for a range of CSC concentrations similar to those required for inducing drug metabolizing enzymes and may therefore be hypothesized to be relevant for smokers. Taken together, these data established human hepatic transporters as targets of cigarette smoke, which could contribute to known alteration of pharmacokinetics and some liver adverse effects caused by smoking. © 2016 Elsevier Ireland Ltd
Toxicology

hal-01367143
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01367143
DOI : 10.1016/j.tox.2016.07.011
PUBMED : 27450509

Éditeur(s) : Archives de la Martinique
15Fi11
Saint-Pierre

Droits : Reproduction soumise à autorisation des Archives de la Martinique
http://www.patrimoines-martinique.org/ark:/35569/a011470672738wZL6mV

Éditeur(s) : HAL CCSD Nature Publishing Group
Résumé : International audience
The variation of elastic- wave velocities as a function of the direction of propagation through the Earth's interior is a widely documented phenomenon called seismic anisotropy. The geometry and amount of seismic anisotropy is generally estimated by measuring shearwave splitting, which consists of determining the polarization direction of the fast shear- wave component and the time delay between the fast and slow, orthogonally polarized, waves. In subduction zones, the teleseismic fast shear- wave component is oriented generally parallel to the strike of the trench(1), although a few exceptions have been reported (Cascadia(2) and restricted areas of South America(3,4)). The interpretation of shear- wave splitting above subduction zones has been controversial and none of the inferred models seems to be sufficiently complete to explain the entire range of anisotropic patterns registered worldwide(1). Here we show that the amount and the geometry of seismic anisotropies measured in the forearc regions of subduction zones strongly depend on the preferred orientation of hydrated faults in the subducting oceanic plate. The anisotropy originates from the crystallographic preferred orientation of highly anisotropic hydrous minerals (serpentine and talc) formed along steeply dipping faults and from the larger- scale vertical layering consisting of dry and hydrated crust - mantle sections whose spacing is several times smaller than teleseismic wavelengths. Fault orientations and estimated delay times are consistent with the observed shear- wave splitting patterns in most subduction zones.
ISSN: 0028-0836

hal-00412016
https://hal.archives-ouvertes.fr/hal-00412016
DOI : 10.1038/nature07376

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The correlation between the flow turbulence and the performances of a ma- rine current turbine is studied. First, the incoming flow encountered in the flume tank is characterized in the framework of fully developed turbulent cascades in the inertial range. The Reynolds number, the Kolmogorov dissipation scale and the integral scale, are estimated from flow measurements. The intermittency of the turbulence is characterized in the lognormal multifractal framework, and the influence of the turbulent flow on the turbine power is assessed. The rotor speed control unit characteristics used for the turbine regulation induces non-negligible effects on the turbine behavior under fluctuations loads. Even if the power spectrum does not reveal any scale invariance, a multiscale analysis allows us to show the correlations between the turbulence time se- ries and the power produced. The classical Mean Square Coherency function shows that for scales larger than 10 seconds, the upstream velocity and power have large correlations. In the framework of the Empirical Mode Decomposition method, such correlations are studied using the time-dependence intrinsic corre- lation analysis method. This method allows to zoom into time-frequency scales where the flow perturbations induced some modifications in power production
ISSN: 0960-1481

hal-01528296
https://hal.archives-ouvertes.fr/hal-01528296
DOI : 10.1016/j.renene.2017.05.024

Éditeur(s) : HAL CCSD
Résumé : 15 pages
A Stochastic Differential Equation appearing in the statistical theory of turbulence is extended in random environment by assuming that its two parameters are switched by an unobserved continuoustime Markov chain whose states represent the states of the environment. A Dirichlet process is placed as a prior on the space of the sample paths of this chain, leading to a hierarchical Dirichlet model whose estimation is done both on simulated data and on real data of wind speed measured at the entrance of a mangrove ecosystem.
https://hal.archives-ouvertes.fr/hal-00455050

hal-00455050
https://hal.archives-ouvertes.fr/hal-00455050
https://hal.archives-ouvertes.fr/hal-00455050/document
https://hal.archives-ouvertes.fr/hal-00455050/file/CSDA06_Srik_Hal.pdf

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Binding of ligand FasL to its receptor Fas triggers apoptosis via the caspase cascade. FasL itself is homotrimeric, and a productive apoptotic signal requires that FasL be oligomerized beyond the homotrimeric state. We generated a series of FasL chimeras by fusing FasL to domains of the Leukemia Inhibitory Factor receptor gp190 which confer homotypic oligomerization, and analyzed the capacity of these soluble chimeras to trigger cell death. We observed that the most efficient FasL chimera, called pFasL, was also the most polymeric, as it reached the size of a dodecamer. Using a cellular model, we investigated the structure-function relationships of the FasL/Fas interactions for our chimeras, and we demonstrated that the Fas-mediated apoptotic signal did not solely rely on ligand-mediated receptor aggregation, but also required a conformational adaptation of the Fas receptor. When injected into mice, pFasL did not trigger liver injury at a dose which displayed anti-tumor activity in a model of human tumor transplanted to immunodeficient animals, suggesting a potential therapeutic use. Therefore, the optimization of the FasL conformation has to be considered for the development of efficient FasL-derived anti-cancer drugs targeting Fas.
ISSN: 1932-6203

hal-00873684
https://hal.archives-ouvertes.fr/hal-00873684
https://hal.archives-ouvertes.fr/hal-00873684/document
https://hal.archives-ouvertes.fr/hal-00873684/file/Functional_Characterization-accepted.pdf
DOI : 10.1371/journal.pone.0054000

Éditeur(s) : Inter-research
Résumé : Marine protected areas (MPAs) have the potential to enhance the long-term sustainability of coastal resources, and the artisanal fisheries which depend on them. However, recreational fisheries, which are increasing their impacts on coastal resources worldwide, may reduce the benefits that MPAs provide to declining artisanal fisheries. Here we used the Bonifacio Straits Natural Reserve (BSNR) Corsica as a study case to simulate the combined effects on coastal resources of artisanal and recreational fishing efforts. The BSNR ecosystem was modelled using mass-balance modelling of trophic interactions. This model was compared to another built on a non-protected area from the same region. We aggregated fishing fleets into artisanal and recreational categories, and we simulated various combinations of fishing effort over a 20 yr dynamic simulation using Ecosim. We showed that fishing activities have an additional top-down effect on the food web and that they decrease the targeted group's biomass, such as piscivorous species. We found, for some trophic groups, non-trivial patterns of biomass variation through trophic cascades. Our trophic approach revealed that some groups may suffer a biomass decrease when MPAs are set or enforced, due to the combined effect of artisanal and recreational fisheries. Overall, our results illustrate the value of modelling to manage MPAs, as a complementary tool to surveys. Models provide the opportunity to anticipate the potential consequences, at the ecosystem level, of socio-political decisions that aim to sustain coastal resources while managing artisanal and recreational fisheries.
Marine Ecology-progress Series (0171-8630) (Inter-research), 2010-08 , Vol. 412 , P. 207-221

Droits : Inter-Research 2010
http://archimer.ifremer.fr/doc/00013/12436/9246.pdf
http://archimer.ifremer.fr/doc/00013/12436/9247.pdf
DOI:10.3354/meps08679
http://archimer.ifremer.fr/doc/00013/12436/