Éditeur(s) : HAL CCSD
Résumé : International audience
OBJECTIVE: To assess sperm production and aneuploidy in Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) before and after treatments. DESIGN: Multicenter, prospective, longitudinal study of lymphoma patients analyzed before treatment and after 3, 6, 12, and 24 months. SETTING: University hospitals. PATIENT(S): Forty-five HL and 13 NHL patients were investigated before and after treatment. Treatment regimens were classified in two groups: ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine) with or without (+/-) radiotherapy, and CHOP (doxorubicin, cyclophosphamide, vincristine, prednisone)/MOPP-ABV (mechlorethamine, oncovin, procarbazine, prednisone-doxorubicin, bleomycin, vinblastine). A control group of 29 healthy men was also studied. INTERVENTION(S): Semen analyses and aneuploidy study by FISH were performed at each time point. MAIN OUTCOME MEASURE(S): Comparison of mean sperm characteristics and percentage of sperm aneuploidy rates before and after treatment. RESULT(S): Before treatment, HL and NHL men had altered semen characteristics and higher sperm aneuploidy rates (median 0.76 [interquartile range 0.56-0.64]) than the control group (0.54 [0.46-0.74]). After treatment, sperm production was significantly lowered 3 and 6 months after ABVD +/- radiotherapy or CHOP/MOPP-ABV. After ABVD +/- radiotherapy, the aneuploidy rate increased significantly only at 3 months, and values obtained 1 or 2 years later were lower than pretreatment values. In contrast, in the CHOP/MOPP-ABV treatment group, semen characteristics and aneuploidy rate did not return to normal levels until 2 years after treatment. CONCLUSION(S): Lymphoma itself has consequences on sperm aneuploidy frequency before treatment. Moreover, lymphoma treatments have deleterious effects on sperm chromosomes related to treatment type and time since treatment. Patient counseling is essential concerning the transient but significant sperm aneuploidy induced by lymphoma and its treatments.
Fertility and sterility

hal-01477204
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01477204
DOI : 10.1016/j.fertnstert.2016.10.001
PUBMED : 27810161

Éditeur(s) : HAL CCSD
Résumé : International audience
To assess prognostic factors for survival and describe Model for End-Stage liver disease (MELD) dynamics in human immunodeficiency virus+/hepatitis C virus+ (HIV+/HCV+) patients after an initial episode of hepatic decompensation.An HIV+/HCV+ cohort of patients experiencing an initial decompensation episode within the year preceding enrollment were followed prospectively. Clinical and biological data were collected every 3 months. Predictors for survival were identified using Kaplan-Meier curves and Cox models. A 2-slope-mixed linear model was used to estimate MELD score changes as a function of survival.Sixty seven patients were included in 32 centers between 2009 and 2012 (72% male; median age: 48 years [interquartile ratio (IQR):45-52], median follow-up: 22.4 months [range: 0.5-65.3]). Overall survival rates were 86%, 78%, and 59% at 6, 12, and 24 months, respectively. Under multivariate analysis, the MELD score at initial decompensation was predictive of survival, adjusted for age, type of decompensation, baseline CD4 counts, and further decompensation during follow-up as a time-dependent variable. The adjusted hazard ratio of death was 1.32 for a score 3 points higher (95% CI: [1.06-1.63], P = 0.012). MELD score kinetics within the 6 months after initial decompensation differed significantly between non-deceased and deceased patients, with a decreased (-0.49/month; P = 0.016), versus a flat (+0.06/month, P = 0.753) mean change in score.MELD is an effective tool to predict survival in HIV+/HCV+ patients with decompensated cirrhosis. A non-decreasing MELD score within 6 months following this initial decompensation episode may benefit from privileged access to liver transplantation in this poor prognosis population
Medicine

hal-01205351
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01205351
DOI : 10.1097/MD.0000000000001239
PUBMED : 26222860

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Deep crustal and mantle rocks are exhumed in core complex mode of extension in three types of structures: metamorphic core complexes, oceanic core complexes and magma poor passive margins. Using available analogue and numerical models and their comparison with natural examples, the present paper reviews the mechanical processes involved in these different types of extensional setting. Three main aspects are considered: i) the primary role of lithosphere rheology, ii) the lithosphere-scale patterns of progressive deformation that lead to the exhumation of deep metamorphic or mantle rocks and iii) the initiation and development of detachment zones. Crustal core complexes develop in continental lithospheres whose Moho temperature is higher than 750 °C with “upper crust-dominated” strength profiles. Contrary to what is commonly believed, it is argued from analogue and numerical models that detachments that accommodate exhumation of core complexes do not initiate at the onset of extension but in the course of progressive extension when the exhuming ductile crust reaches the surface. In models, convex upward detachments result from a rolling hinge process. Mantle core complexes develop in either the oceanic lithosphere, at slow and ultra-slow spreading ridges, or in continental lithospheres, whose initial Moho temperature is lower than 750 °C, with “sub-Moho mantle-dominated” strength profiles. It is argued that the mechanism of mantle exhumation at passive margins is a nearly symmetrical necking process at lithosphere scale without major and permanent detachment, except if strong strain localization could occur in the lithosphere mantle. Distributed crustal extension, by upper crust faulting above a décollement along the ductile crust increases toward the rift axis up to crustal breakup. Mantle rocks exhume in the zone of crustal breakup accommodated by conjugate mantle shear zones that migrate with the rift axis, during increasing extension.
ISSN: 0040-1951

insu-01610186
https://hal-insu.archives-ouvertes.fr/insu-01610186
https://hal-insu.archives-ouvertes.fr/insu-01610186/document
https://hal-insu.archives-ouvertes.fr/insu-01610186/file/brun-tect-2017.pdf
DOI : 10.1016/j.tecto.2017.09.017

Éditeur(s) : HAL CCSD
Résumé : International audience
Traffic air pollution is a major health problem and is recognized as an important risk factor for cardiovascular disease. Even so the role of particles-induced adverse health effects is well established, recent studies outlined the contribution of nitrogen dioxide (NO2) in these effects, in particular on the cardiovascular function. The main sources of this pollutant are oxidation catalysts used to reduce emissions of carbon monoxide and non-methane hydrocarbons from the exhaust of diesel engines and also to facilitate filter regeneration. However, the contribution of NO2 compared to other gaseous and particulate pollutants remains unknown. Consequently, the main objective of this study was to analyze the specific contributions of NO2 in the traffic-related air pollution-induced cardiovascular adverse effects. For this, Wistar rats were exposed for 3 weeks (3h/day, 5 days/week) to either a continuous flow of catalyzed diesel exhaust (DE), particle free or whole DE (particles concentration 2mg/m3), either to a continuous flow of NO2 used at a concentration identical to that measured in the exhaust line. The composition of the emission and the NO2 analyses were monitored on-line during the whole experiment. We evaluated cardiac function and biological effects after 16h recovery in clean air. DE or NO2 exposures induced a modest cardiac dysfunction characterized by an increase in left ventricular diameters and a decrease in fractional shortening. In the case of DE, the presence of particles did not worsen the impairment of cardiac function. In parallel to this effect, mitochondrial function was altered as illustrated by the reduction of the oxygen consumption and of the ATP production. Mitochondrial reactive oxygen species was increased only by the NO2 exposure. In conclusion, these results suggest that DE-induced cardiac dysfunction is due to, at least in part, to NO2 present in DE.
Archives of Cardiovascular Diseases Supplements
Toulouse, France

hal-01150495
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01150495
DOI : 10.1016/S1878-6480(15)30036-7

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
Background: An environmental health inequality is a major public health concern in Europe. However just few studies take into account a large set of characteristics to analyze this problematic. The aim of this study was to identify and describe how socioeconomic, health accessibility and exposure factors accumulate and interact in small areas in a French urban context, to assess environmental health inequalities related to infant and neonatal mortality.Methods: Environmental indicators on deprivation index, proximity to high-traffic roads, green space, and healthcare accessibility were created using the Geographical Information System. Cases were collected from death certificates in the city hall of each municipality in the Nice metropolitan area. Using the parental addresses, cases were geocoded to their census block of residence. A classification using a Multiple Component Analysis following by a Hierarchical Clustering allow us to characterize the census blocks in terms of level of socioeconomic, environmental and accessibility to healthcare, which are very diverse definition by nature. Relation between infant and neonatal mortality rate and the three environmental patterns which categorize the census blocks after the classification was performed using a standard Poisson regression model for count data after checking the assumption of dispersion.Results: Based on geographic indicators, three environmental patterns were identified. We found environmental inequalities and social health inequalities in Nice metropolitan area. Moreover these inequalities are counterbalance by the close proximity of deprived census blocks to healthcare facilities related to mother and newborn. So therefore we demonstrate no environmental health inequalities related to infant and neonatal mortality.Conclusion: Examination of patterns of social, environmental and in relation with healthcare access is useful to identify census blocks with needs and their effects on health. Similar analyzes could be implemented and considered in other cities or related to other birth outcomes.
ISSN: 1476-069X

halshs-01366285
https://halshs.archives-ouvertes.fr/halshs-01366285
https://halshs.archives-ouvertes.fr/halshs-01366285/document
https://halshs.archives-ouvertes.fr/halshs-01366285/file/art_10.1186_s12940-016-0163-7.pdf
PUBMED : 27449640

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : CCBY
National audience
ISSN: 0761-8425

hal-01117879
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01117879
PUBMED : 24314711
DOI : 10.1016/j.rmr.2013.09.007

Éditeur(s) : HAL CCSD
Résumé : International audience
o abstract
Revue Des Maladies Respiratoires

hal-01647079
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01647079
DOI : 10.1016/j.rmr.2017.07.019
PUBMED : 28939154

Éditeur(s) : HAL CCSD
Résumé : International audience
Idiopathic pulmonary fibrosis (IPF) is the most frequent chronic idiopathic interstitial pneumonia in adults. The management of rare diseases in France has been organised by a national plan for rare diseases, which endorsed a network of expert centres for rare diseases throughout France. This article is an overview of the executive summary of the French guidelines for the management of IPF, an initiative that emanated from the French National Reference Centre and the Network of Regional Competence Centres for Rare Lung Diseases. This review aims at providing pulmonologists with a document that: 1) combines the current available evidence; 2) reviews practical modalities of diagnosis and management of IPF; and 3) is adapted to everyday medical practice. The French practical guidelines result from the combined efforts of a coordination committee, a writing committee and a multidisciplinary review panel, following recommendations from the Haute Autorité de Santé. All recommendations included in this article received at least 90% agreement by the reviewing panel. Herein, we summarise the main conclusions and practical recommendations of the French guidelines.
Eur Respir Rev

hal-01063982
https://hal.archives-ouvertes.fr/hal-01063982
DOI : 10.1183/09059180.00001814
PUBMED : 24881074

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Volumetrically minor microsyenites, alkali microgranite and related trachytic dykes intrude early Pliocene OIB-like alkali basaltic and basanitic flows of the Meseta del Lago Buenos Aires in Central Patagonia (47 degrees S-71 degrees 30'W), and occur together with scarce trachytic lava flows. Whole-rock K-Ar ages between 3.98 and 3.08 Ma indicate that the emplacement of these felsic rocks occurred more or less synchronously with that of the post-plateau basaltic sequence that they intrude, during a bimodal mafic-felsic magmatic episode devoid of intermediate compositions. Chemically, these rocks have A(1)-type granitoid affinities and are characterized by high silica and alkali contents (60-68 wt.% SiO2; 8.7-10.8 wt.% Na2O+K2O), major and trace elements patterns evidencing evolution by low-pressure fractional crystallization, and Sr and Nd isotopic signatures similar to those of coeval basalts ((Sr-87/Sr-86)o=0.70488-0.70571; (Nd-143/Nd-144)(o)=0.512603-0.512645). Nevertheless, some of them have the most radiogenic Sr values ever reported for a magmatic rock in the Meseta and even in the whole Neogene Patagonian Plateau Lavas province ((Sr-17/Sr-86)(o)= 0.70556-0.70571; (Nd-143/Nd-144)(o)=0.512603-0.512608). In addition, very high contents of strongly incompatible elements in the most evolved rocks, together with Sr isotopic ratios higher than those of coeval basalts, suggest the occurrence of open-system magmatic processes. Continuous fractional crystallization from a primitive basaltic source, similar to post-plateau coeval basalts, towards alkali granites combined with small rates of assimilation of host Jurassic tuffs (AFC) in a shallow magmatic reservoir, best explains the geochemical and petrographic features of the felsic rocks. Therefore, A(1)-type magmatic rocks can be generated by open-system crystallization of deep asthenospheric melts in back-are tectonic settings. In Central Patagonia, these similar to 3-4 Ma old alkaline intrusions occur aligned along a similar to N160-170 trending lineament, the Zeballos Fault Zone, stacking the morphotectonic front of one segment of the Patagonian Cordillera. Intrusion along this fault zone
ISSN: 0024-4937

hal-00412030
https://hal.archives-ouvertes.fr/hal-00412030
DOI : 10.1016/j.lithos.2007.07.002

Éditeur(s) : HAL CCSD
Résumé : International audience
2010 ASCO Annual Meeting
Chicago, United States

hal-01127991
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01127991

Éditeur(s) : HAL CCSD Coastal Education and Research Foundation, Inc.
Résumé : International audience
Morphodynamics of sandy, macrotidal, embayed beaches is complex because of the numerous physical processes interacting at the same location over a wide range of temporal scales. As most of these processes are controlled by beach morphology, dynamic feedbacks are generally observed between hydro- and morphodynamics. Investigating short-term processes is essential in order to improve long term morphological prediction. A key question is to understand how beach slope reacts to forcing conditions, in particular the response time of the beach profile, how long the transient state lasts. This study deals with the spatial and temporal responses of beach morphology to varying incident conditions. Here we report main observations, preliminary results and on-going investigations on the DYNATREZ1 field campaign, which was conducted in the framework of the National Observation Service Dynalit. Beach profiles are shown to adapt rapidly to forcing conditions, within two days, with more intense variations observed in the high tide swash zone. The presence of infragravity waves and their dissipation on the beach is highlighted. It is likely that the very large variability in beach slope observed over a single neapspring cycle is responsible for the accordingly large variability in wave skewness, asymmetry and breaking processes, and thus in sediment fluxes and morphological changes.
ICS 2016 Sydney
Sydney, Australia

hal-01254465
https://hal.archives-ouvertes.fr/hal-01254465
DOI : 10.2112/SI75-075.1

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Middle to Late Triassic lavas were sampled within three tectonostratigraphic groups of the Hawasina Nappes in the Oman Mountains. They are predominantly alkali basalts and trachybasalts, associated with minor sub-alkaline basalts, trachyandesites, trachytes and rhyolites. Their major, trace elements and Nd-Pb isotopic compositions are very similar to those of the Permian plume-related high-Ti basalts which also occur in the Hawasina Nappes. The Triassic lavas derive from low-degree melting of an enriched OIB-type mantle source, characterized by εNdi = 0.3-5.3 and (206Pb/204Pb)i = 16.96-19.31 (for t = 230 My). With time, melting depths decreased from the garnet + spinel to the spinel lherzolite facies and the degree of melting increased. The oldest are distinguished from the others by unradiogenic Nd and Pb signatures, with εNdi = − 4.5 to − 1.2 and (206Pb/204Pb)i = 16.35-17.08, which we attribute to their contamination by Arabo-Nubian lower crust. The lavas likely derived from the Oman lithospheric mantle, the original DMM-HIMU signature of which was overprinted during its pervasive metasomatism by the Permian plume-related melts. We suggest that these lavas were emplaced during post-breakup decompression-triggered melting in the Middle Triassic during global kinematic reorganization of the Tethyan realm.
ISSN: 0024-4937

insu-00559080
https://hal-insu.archives-ouvertes.fr/insu-00559080
https://hal-insu.archives-ouvertes.fr/insu-00559080/document
https://hal-insu.archives-ouvertes.fr/insu-00559080/file/FC_TriasOman.pdf
DOI : 10.1016/j.lithos.2010.12.006

Éditeur(s) : HAL CCSD MDPI
Résumé : International audience
Lead in childhood is well known to be associated with poor neurodevelopment. As part of a study on maternal anemia and offspring neurodevelopment, we analyzed blood lead level (BLL) with no prior knowledge of lead exposure in 225 mothers and 685 offspring 1 to 2 years old from Allada, a semi-rural area in Benin, sub-Saharan Africa, between May 2011 and May 2013. Blood samples were analyzed by inductively coupled plasma mass spectrometry. Environmental assessments in households and isotopic ratio measurements were performed for eight children with BLL extgreater 100 µg/L. High lead levels (BLL extgreater 50 µg/L) were found in 44% of mothers and 58% of children. The median BLL was 55.1 (interquartile range 39.2-85.0) and 46.6 (36.5-60.1) µg/L, respectively. Maternal BLL was associated with offspring's consumption of piped water and animals killed by ammunition. Children's BLL was associated with presence of paint chips in the house and consumption of animals killed by ammunition. In this population, with 98% of children still breastfed, children's BLL was highly associated with maternal BLL on multivariate analyses. Environmental measures and isotopic ratios supported these findings. Offspring may be highly exposed to lead in utero and probably via breastfeeding in addition to lead paint exposure
ISSN: 1660-4601

hal-01296778
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01296778
DOI : 10.3390/ijerph13030316
PUBMED : 26978384

Éditeur(s) : HAL CCSD
Résumé : International audience
We present a chronological (K-Ar), petrologic and geochemical study (major and trace elements, Sr-Nd isotopes) of Middle Miocene (ca. 16-14 Ma) calc-alkaline rocks (basalts to andesites) extruded in the present-day back-arc region of Central Patagonia (Zeballos Volcanic Sequence (ZVS), 47 S). This magmatism started shortly after mafic plutonism ceased in the arc region (ca. 16 Ma, 200 km west), and ended ca. 2 My before the onset of voluminous slab tear-related back-arc alkaline basaltic magmatism (ca. 12 to Pliocene). The studied calc-alkaline rocks have a typical subduction-related signature (high LILE/HFSE ratios, depletion in Nb, Ta and Ti; Ba/La >20; Ta/Hf <1.5; (Sr-87/Sr-86)(o)=0.70366-0.70402, epsilon(Nd)=+0.1-+3.8). Major and trace elements contents are consistent with their evolution by closed system fractional crystallization of a presumed parental liquid similar in composition to the most basic rock of the suite. Moreover, a strong subducted sediment imprint is recognized (increasing Th/HFSE and decreasing Ce/Pb during differentiation). However, these rocks show striking similarities with volcanic complexes emplaced above areas where a gently dipping slab occurs (high K contents; similar LREE/HREE, Nb/Zr, Ba/Nb; Th/Hf; Th/Ta, Ta/Hf<0.3), particularly the present-day Andean flat-slab region and the Neuquen Basin during the Late Miocene. A comprehensive tectono-magmatic model is here presented to explain the generation and extrusion of these calc-alkaline magmas during the Middle Miocene. The development of a transient low-angle subduction and the resulting eastward migration of the volcanic front are then proposed. Mixing between stored remnants of calc-alkaline magmatism and later primitive alkaline melts is envisioned as the most likely process accounting for the transitional signature (i.e., intermediate between calc-alkaline and alkaline, La/Nb >I; TiO2 <2 wt%) of some basalts extruded synchronously with genuine alkaline lavas in the Neogene Patagonian Plateau Lavas province.
Volcanismo calcoalcalino durante el Mioceno Medio en Patogonia Central (47°S): petrogenesis e implicaciones en la dinamica de placas. En este trabajo se presenta un estudio cronologico (K-Ar), petrologico y geoquimico (elementos mayores y trazas, isotopos de Sr-Nd) de rocas calcoalcalinas (basaltos a andesitas) del Mioceno Medio (16-14 Ma) que ocurren en una posicion de trasarco en Patagonia Central (47°S; Secuencia Volcanica Zeballos, SVZ). Este magmatismo comenzo poco despees de que el plutonismo mafico cesara en la region bajo el arco (ca. 16 Ma, 200 km al oeste), y termino ca. 2 My antes del comienzo de un voluminoso evento magmatico basaltico alcalino desarrollado en el trasarco, relacionado con ventanas astenosfericas, que continuo hasta el Pleistoceno. Las rocas calcoalcalinas estudiadas tienen una quimica tipicamente relacionada con procesos de subduccion (altas razones LILE/HFSE, empobrecimientos en Nb, Ta y Ti; Ba/La>20; Ta/Hf l,5; (87Sr/86Sr)0=0,70366-0,70402, End~O,1±3,8); y sus contenidos de elementos mayores y trazas son consistentes con una evolucion por cristalizacion fraccionada, en un sistema cerrado, desde un liquido parental de composicion similar a la de la roca mas basica del conjunto analizado. Se reconoce, ademas, la influencia de sedimentos subductados en la composicion de estos magmas (aumento de la razon Tb/HFSE y disminucion de la razon Ce/Pb durante la diferenciacion). Sin embargo, estas rocas muestran importantes similitudes composicionales con las de complejos volcanicos emplazados sobre areas donde ocurre subduccion de bajo angulo (altos contenidos de K, similares razones LREF/HREE, Nb/Zr, Ba/Nb; TblHf; TblTa, Ta/Hf O,3), particularmente rocas de la actual region de subduccion plana en Chile central-Argentina y de la cuenca de Neuquen durante el Mioceno Superior. Se propone aqui un modelo tectono-magmatico que explica la generacion y extension de magmas calcoalcalinos en una posicion de trasarco durante el Mioceno Medio en Patagonia mediante el desarrollo de un fenomeno transiente de subduccion de bajo angulo y el consiguiente desplazamiento hacia el este del frente volcanico. Ademas, la mezcla entre remanentes de este magmatismo calcoalcalino almacenados en la corteza y fundidos alcalinos posteriores, provenientes de la astenosfera, se presenta como el proceso responsable de la generacion de la signatura transicional (i.e., intermedia entre calcoalcalina y alcalina, La/Nb>1; TiO2 2 wt%) reconocida en algunos basaltos que ocurren contemporaneamente con otros puramente alcalinos en la provincia de las Lavas Neogenas de Plateau de la Patagonia.
ANDEAN GEOLOGY

insu-00561888
https://hal-insu.archives-ouvertes.fr/insu-00561888
DOI : 10.5027/andgeo2010-678

Éditeur(s) : HAL CCSD Société géologique de France
Résumé : National audience
Late Triassic submarine alkali basalts and hawaiites were collected from two superimposed tectonic slices belonging to the Kara Dere – Sayrun unit of the Middle Antalya nappes, southwestern Turkey. New determinations on conodont faunas allow to date this sequence to the Lower Carnian (Julian). The volcanic rocks show rather homogeneous compositions, with high TiO2 and relatively low MgO and Ni contents which suggest olivine fractionation. Their primitive mantle-normalised multi-elements plots show Nb and Ta enrichments relative to La, Pb negative anomalies and heavy rare earth element and Y depletions typical of intraplate ocean island basalts. These characteristics are consistent with the major and trace element compositions of their primary clinopyroxene phenocrysts, which do not show any feature ascribable to crustal contamination. The studied lavas display a restricted range of {varepsilon}Nd (+4.6 to +5.2) which falls within the range of ocean island basalts. Their initial (143Nd/144Nd)i ratios are too low to be explained by a simple mixing line between depleted MORB mantle (DMM) and HIMU components. Their Pb and Nd isotopic compositions plot along a mixing line between HIMU component and an enriched mantle, the composition of which could be the result of the addition of about 5 to 8% of an EM2 component (recycled marine sediments) to DMM. The lack of evidence for any continental crustal component in their genesis could be consistent with their emplacement in an intra-oceanic setting.
EISSN: 1777-5817

insu-00338829
https://hal-insu.archives-ouvertes.fr/insu-00338829
DOI : 10.2113/gssgfbull.179.4.397