Éditeur(s) : HAL CCSD
Résumé : International audience
Two opposing visions of the Aegean backarc tectonics implicitly contain contrasting images of the rheological behaviour of the lihosphere, supported by different sets of observations. The propagation of the NAF and extension in the Corinth Rift suggest a strongly localising rheology whereas the formation of MCC in the Cyclades and the Rhodope suggests instead a more viscous behaviour. This paradox was the seminal question addressed by the ANR-EGEO programme (2007-2010) that leads to the following conclusions: (1) The exhumation of the Cycladic MCC's is accommodated by the N-dipping North Cycladic Detachment System (NCDS) that partly reworks the Vardar suture and at the base by a series of thrusts, including the basal contact of the Cycladic Blueschists (CBS) over the Cycladic Basement (CB). The activity of LANF is due to the reactivation of pre-existing discontinuities such as thrusts or earlier detachments and much less to the interaction with granitic plutons. (2) Exhumation in the Cyclades has proceeded in two stages: (a) Eocene syn-orogenic exhumation within the subduction lower/upperplate interface while the post-orogenic Rhodope MCC formed further north, (b) Oligo-Miocene post-orogenic extension in an MCC mode coeval with syn-orogenic exhumation in Crete and the Peloponnese. (3) Both stages were associated with slab retreat, as early as the Eocene with an acceleration at 30-35 Ma. (4) The localisation of the presently active steeply-dipping normal faults on the southern margin of the Corinth Rift may have been preceded by a partial reworking of thrusts and syn-orogenic detachments by shallow-dipping decollements. (5) The localisation of the NAF in the Marmara Sea region and the Northern Aegean Sea is now accurately dated between 5.3 and 5 Ma Ma using the erosion and deposition surfaces that mark the Messinian salinity Crisis and nannofossils ages. (6) The formation of MCCs in the Cyclades resulted in the draining of the low viscosity lower crust from the northern Aegean Sea and led to an easier coupling between upper mantle and upper crust, easing the localisation and propagation of the NAF. (7) A comparison between crustal and mantle finite strain suggests that mantle flow due to slab retreat controls the stretching of the crust. Our model involves progressive slab retreat and mantle flow below the overriding plate inducing the observed succession of tectonic episodes with a progressive localisation of extension due to several slab tearing events. There is no paradox in the tectonic history and rheological behaviour of the Aegean lithosphere but an evolution of the kinematic boundary conditions due to slab deformation at depth.
American Geophysical Union
San Francisco, United States

insu-00860518
https://hal-insu.archives-ouvertes.fr/insu-00860518
BIBCODE : 2010AGUFM.T13G..04J

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
We aimed to assess the impact of a postoperative drainage after RPN. A retrospective multicentric study included RPN performed at eight centers between 2010 and 2014. Three centers stopped using postoperative drainage early in their RPN experience, whereas other institutions systematically left a drain. Preoperative characteristics, complication rates, need for postoperative imaging or procedure (surgical or radiological) and length of hospital stay were compared between the two groups [drainage (D) and no drainage (ND)]. Among 636 RPNs, 140 were done without drainage (22 %). In the ND group, surgeons were more experienced (> 50 cases: 55.7 vs. 15.1 %; p < 0.0001), and tumors were more complex (RENAL score: 7.6 vs. 6.5; p < 0.0001). Complication rates were similar in both groups (21.9 vs. 20.2 %; p = 0.67). The omission of postoperative drainage did not increase requirement of CT scan (RR = 1.03; 95 % CI 0.64-1.67). Length of hospital stay was shorter in the ND group (4.5 vs. 5.5 days; p = 0.007). There were six urinary fistulas: four in the D group (0.8 %) and two in the ND group (1.4 %; p = 0.49). A CT scan was done to confirm the diagnosis of fistula in every case. In multivariate analysis, the omission of drainage was not associated with increased need of postoperative CT scan or major complications but was a predictor of decreased length of stay. The omission of postoperative drainage does not seem to increase the risk of postoperative complications and could safely be omitted after RPN.
ISSN: 0724-4983

hal-01361502
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01361502
DOI : 10.1007/s00345-015-1721-2
PUBMED : 26511751

Éditeur(s) : HAL CCSD
Résumé : International audience
10ème congrès international de l'association des chercheurs en activités physiques et sportives
Toulouse, France

hal-01633111
https://hal.archives-ouvertes.fr/hal-01633111
https://hal.archives-ouvertes.fr/hal-01633111/document
https://hal.archives-ouvertes.fr/hal-01633111/file/acaps%20robin%20nicolas%202003.pdf

Éditeur(s) : HAL CCSD
Résumé : International audience
Sedimentary basins, through the sedimentary successions and the nature of the deposits, reflect the geology of thearea from which the sediments were derived and thus provide valuable record of hinterland tectonism. As the collisionbetween the South China and the Indochina blocks (i.e. the Indosinian orogeny) is still the object of a numberof controversies regarding, for instance, its timing and the polarity of the subduction, the sedimentary basins associatedwith this mountain belt are likely to provide clues to reconstruct its geodynamic evolution. However, boththe Sam Nua Basin (located to the south of the inner zones of the Indosinian orogeny and the Song Ma ophiolites)and the Song Da Basin (located to the north of the inner zones), northern Vietnam, are still lacking importantinformation regarding the depositional environments and the ages of the main formations that they contain.Using sedimentological and dating analyses (foraminifers biostratigraphy and U-Pb dating on detrital zircon), weprovide a new stratigraphic framework for these basins and propose a geodynamic evolution of the present-daynorthern Vietnam.During the Early Triassic, the Sam Nua Basin was mainly supplied by volcaniclastic sediments originating froman active volcanic activity. Geochemical investigations, combined with sedimentological and structural analyses,support an arc-related setting for this magmatism. This magmatic arc resulted from the subduction of a south dippingoceanic slab that once separated the South China from the Indochina blocks. During the Middle to the LateTriassic, the Sam Nua Basin underwent erosion that lead to the formation of a major unconformity, termed theIndosinian unconformity. This unconformity is interpreted to result from the erosion of the Indosinian mountainbelt, built after the continental collision between the South China and the Indochina blocks. Later, during the LateTriassic, the Sam Nua Basin experienced the deposition of very coarse material, emplaced under continental settingand representing the product of the erosion of the Indosinian mountain belt.To the North, the Song Da Basin is characterized by strongly diachronous deposits over a basal unconformitydeveloped at the expense of volcanic and volcaniclastic deposits related to the Emeishan Large Igneous Province.The sedimentary succession indicates a foreland setting during the Early to the Middle Triassic, which contrastswith the commonly assumed rift setting for these sediments. Thus, the Song Da Basin documents the formation ofthe Indosinian thrust belt, located immediately to the South of the basin.
European Geosciences Union General Assembly 2017
Vienne, Austria

insu-01510331
https://hal-insu.archives-ouvertes.fr/insu-01510331

Éditeur(s) : HAL CCSD
Résumé : International audience
In vitro susceptibility of 933 Candida isolates, from 16 French hospitals, to micafungin was determined using the Etest in each center. All isolates were then sent to a single center for determination of MICs by the EUCAST reference method. Overall essential agreement between the two tests was 98.5% at ±2 log2 dilutions and 90.2% at ±1 log2 dilutions. Categorical agreement was 98.2%. The Etest is a valuable alternative to EUCAST for the routine determination of micafungin MICs in medical mycology laboratories. Copyright © 2016, American Society for Microbiology. All Rights Reserved.
Antimicrobial Agents and Chemotherapy

hal-01367142
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01367142
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01367142/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01367142/file/Multicenter%20comparison%20of%20the%20Etest.pdf
DOI : 10.1128/AAC.00630-16

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The Tarim and Junggar basins in central Asia are capped by a thick pile of conglomerates, called the Xiyu Formation, that are commonly linked to a change in climate and/or accelerated uplift near the Plio-Pleistocene boundary. In order to better understand their origin and significance, we carried out a combined structural and magnetostratigraphic study in the Quilitage syncline (southern Tianshan), where the base of the Xiyu conglomerates is observed at both sides of the syncline. A balanced cross-section shows that, even at a local-scale, the base of the Xiyu conglomerates cannot be regarded as a single continuous stratigraphic layer. On the southern flank of the Quilitage syncline, we collected 172 samples collected for magnetostratigraphic dating identify 17 polarity chrons that date the new section from 5.2 to ~ 1.7 Ma and constrain the base of the Xiyu conglomerate here at ~ 1.7 Ma. This is 4.2 Ma younger than the age of the Xiyu previously found on the northern limb of the same syncline. Together with other magnetostratigraphic studies carried out around the Tianshan, our study unambiguously demonstrates that the onset of deposition of the Xiyu conglomerates is diachronous, and that the conglomerates are systematically younger toward the basin. Consequently, the Xiyu Formation should not be considered as a chronostratigraphic marker related to any particular tectonic or climatic event, but is instead a prograding gravel wedge that has prograded over the underthrusting forelands. A synthesis of chronologic and structural results yields progradation rates over the last 10 Ma on the order of ~ 2.0 mm/yr and ~ 3.9 mm/yr south and north of the Tianshan Mountains respectively. These rates are comparable to the shortening rate across the Tianshan range, suggesting that underthrusting is the main factor governing the progradation rate of the Xiyu Formation.
ISSN: 0012-821X

insu-00414151
https://hal-insu.archives-ouvertes.fr/insu-00414151
https://hal-insu.archives-ouvertes.fr/insu-00414151/document
https://hal-insu.archives-ouvertes.fr/insu-00414151/file/Charreau-EPSL-2009.pdf
DOI : 10.1016/j.epsl.2009.07.035

Éditeur(s) : HAL CCSD American Geophysical Union (AGU)
Résumé : International audience
The current structure of the South Armorican Domain in the French Variscan Belt, provides an excellent record of the late orogenic evolution, as documented by the complex interactions between extensional structures and partial melting. In the Golfe du Morbihan, the South Brittany Migmatite Belt (SBMB), tectonically overlain by non-melted metamorphic units, was studied by combined structural and 40Ar/39Ar methods. The recognition of successive deformation stages points to a strain continuum initiated at depth at the end of a partial melting event, and continued to near-surface brittle faulting, encompassing ductile strain localization over a major top-to-the-ESE extensional shear zone (SSZ) consistent with an overall WNW-ESE orogen-parallel stretching. This multidisciplinary study making the link between structure, texture, microchemistry and 40Ar/39Ar geochronology allow distinguishing between cooling, recrystallization and syn-tectonic crystallization ages. The first extensional insights, witnessed by dyke intrusion were dated at ~319 ± 6 Ma immediately after the SBMB partial melting. Strain localization along the SSZ, occurred until ~302-298 Ma when SBMB crossed the ductile-brittle transition. Moreover, in situ 40Ar/39Ar analysis, of syn-tectonic white micas sampled in the ductile and brittle structures yield similar ~300 Ma. Formation or reactivation of the SSZ may have occurred during the rapid cooling of the SBMB settled at ~305 Ma by conventional 40Ar/39Ar analysis. Large-scale late orogenic extensional event of the previously overthickened Variscan crust thus lasted over ~20 ± 3 Myr in the same extensional tectonic regime guided by the South Armorican Shear Zone.
ISSN: 0278-7407

insu-00628699
https://hal-insu.archives-ouvertes.fr/insu-00628699
https://hal-insu.archives-ouvertes.fr/insu-00628699/document
https://hal-insu.archives-ouvertes.fr/insu-00628699/file/2010TC002788.pdf
DOI : 10.1029/2010TC002788

Éditeur(s) : HAL CCSD American Chemical Society
Résumé : Four new sesquiterpene alkaloids (1-4) with a β-dihydroagrofuran skeleton and a new triterpenoid (5) were isolated from an ethyl acetate extract of Maytenus oblongata stems. Their structures were elucidated using 1D and 2D NMR spectroscopy as well as MS and ECD experiments. The M. oblongata stem EtOAc extract and the pure compounds isolated were tested for larvicidal activity against Aedes aegypti under laboratory conditions, and compounds 2 and 3 were found to be active.
ISSN: 0163-3864

hal-01603411
https://hal.archives-ouvertes.fr/hal-01603411
DOI : 10.1021/acs.jnatprod.6b00850
PUBMED : 28186749
PRODINRA : 406747

Éditeur(s) : HAL CCSD American Physiological Society
Résumé : International audience
Excessive or persistent inflammation and hepatocyte death are the key triggers of liver diseases. The poly(ADP-ribose) polymerase (PARP) proteins induce cell death and inflammation. Chemical inhibition of PARP activity protects against liver injury during concanavalin A (ConA)-induced hepatitis. In this mice model, ConA activates immune cells, which promote inflammation and induce hepatocyte death, mediated by the activated invariant natural killer T (iNKT) lymphocyte population. We analyzed immune cell populations in the liver and several lymphoid organs, such as the spleen, thymus, and bone marrow in Parp2-deficient mice to better define the role of PARP proteins in liver immunity and inflammation at steady state and during ConA-induced hepatitis. We show that 1) the genetic inactivation of Parp2, but not Parp1, protected mice from ConA hepatitis without deregulating cytokine expression and leucocyte recruitment; 2) cellularity was lower in the thymus, but not in spleen, liver, or bone marrow of Parp2-/- mice; 3) spleen and liver iNKT lymphocytes, as well as thymic T and NKT lymphocytes were reduced in Parp2 knockout mice. In conclusion, our results suggest that the defect of T-lymphocyte maturation in Parp2 knockout mice leads to a systemic reduction of iNKT cells, reducing hepatocyte death during ConA-mediated liver damage, thus protecting the mice from hepatitis.NEW & NOTEWORTHY The genetic inactivation of Parp2, but not Parp1, protects mice from concanavalin A hepatitis. Immune cell populations are lower in the thymus, but not in the spleen, liver, or bone marrow of Parp2-deficient mice compared with wild-type mice. Spleen and liver invariant natural killer T (NKT) lymphocytes, as well as thymic T and NKT lymphocytes, are reduced in Parp2-deficient mice
ISSN: 0193-1857

hal-01630440
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01630440
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01630440/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01630440/file/102513_1_merged_1499199857-1.pdf
DOI : 10.1152/ajpgi.00436.2016

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Since the Shea, J.B. and Morgan (1979) study, investigators have repeatedly shown that the learning of a set of movement patterns (as evaluated in a retention test) is enhanced when acquisition occurred under a random rather than a blocked schedule of practice. Supposedly, this is the case because a random schedule of practice necessitates more elaborate cognitive activities than a blocked schedule before each acquisition trial can be initiated. Our main objective was to determine whether the advantage for learning found for random practice increases as a function of the number of acquisition trials. During acquisition, the results indicated a general tendency for smaller movement reproduction errors under a blocked rather than a random schedule of practice. However, this effect disappeared with larger amount of acquisition trials. In retention, larger errors were observed when acquisition occurred under a blocked rather than a random schedule of practice. Finally, the disadvantage for learning observed for the blocked schedule of practice disappeared under a block-repeated condition in which each movement pattern was first practiced under a blocked schedule which was then repeated a second time. The results are discussed in terms of the so-called contextual interference effect and indicates some of its limitations.
ISSN: 0001-6918

hal-01662846
https://hal.archives-ouvertes.fr/hal-01662846
DOI : 10.1080/00222895.1994.9941657
PUBMED : 8165923