Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
BACKGROUND: In the context of recent guidelines on invasive candidiasis (IC), how French intensive care units (ICUs) are managing IC? METHODS: This is a prospective observational multicenter cohort study. During 1 year (2012-2013), 87 French ICUs enrolled consecutive patients with suspected or proven IC (SIC or PIC) and receiving systemic antifungal therapy (SAT). Data were collected up to 28 days after inclusion. RESULTS: We studied 835 patients, 291 with PIC and 544 with SIC. At SAT initiation, patients with SIC were significantly more severe (SAPS II 50.1 ± 18.7 vs. 46.2 ± 18.0). Severe sepsis or septic shock prompted to initiate empiric SAT in 70 % of SIC. Within 4 days in median, the initial SAT was modified in 49 % of patients with PIC vs. 33 % patients with SIC. Modifications were most often motivated by mycological results, and de-escalation was the most frequent change. Regarding compliance to IC management guidelines, echinocandin was used for 182 (62.5 %) patients with PIC, and 287 (52.7 %) of those with SIC; central venous catheter was removed in 87 (54.3 %) of patients with candidaemia, and 43 of the remaining patients received echinocandin; and de-escalation was undertaken after 5 days of SAT in 142 patients, after 10 days in 13 patients. As 20.6 % of SIC were secondarily documented, 403/835 (48 %) patients had finally a proven IC. Candida albicans was the main pathogen (65.3 %), then Candida glabrata (15.9 %). The 28-day mortality rates were 40.0 % in candidaemia, 25.4 % in cIAI, and 26.7 % in deep-seated candidiasis. In the overall population of patients with proven IC, four independent prognostic factors were identified: immunosuppression (Odds Ratio (OR) = 1.977: 1.03-3.794 95 % confidence interval (CI), p = 0.04), age (OR = 1.035; 1.017-1.053 95 % CI; p  extless 0.001), SAPS extgreater46 on ICU admission (OR = 2.894; 1.81-4.626 95 % CI; p  extless 0.001), and surgery just before or during ICU stay (OR = 0.473; 0.29-0.77 95 % CI; p  extless 0.001). CONCLUSION: When SAT is initiated in French ICUs, the IC is ultimately proven for 48 % of patients. Empiric SAT is initiated in severely ill ICU patients. The initial SAT is often adapted, with de-escalation to fluconazole when possible. Mortality rate remains high
ISSN: 2110-5820

hal-01259216
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01259216
DOI : 10.1186/s13613-015-0103-7
PUBMED : 26743881

Éditeur(s) : HAL CCSD Nature Publishing Group
Résumé : International audience
Androgen signaling, via the androgen receptor (AR), is crucial in mediating prostate cancer (PCa) initiation and progression. Identifying new downstream effectors of the androgens/AR pathway will allow a better understanding of these mechanisms and could reveal novel biomarkers and/or therapeutic agents to improve the rate of patient survival. We compared the microRNA expression profiles in androgen-sensitive LNCaP cells stimulated or not with 1 nM R1881 by performing a high-throughput reverse transcriptase-quantitative PCR and found that miR-135a was upregulated. After androgen stimulation, we showed that AR directly activates the transcription of miR-135a2 gene by binding to an androgen response element in the promoter region. Our findings identify miR-135a as a novel effector in androgens/AR signaling. Using xenograft experiments in chick embryos and adult male mice, we showed that miR-135a overexpression decreases in vivo invasion abilities of prostate PC-3 cells. Through in vitro wound-healing migration and invasion assays, we demonstrated that this effect is mediated through downregulating ROCK1 and ROCK2 expression, two genes that we characterized as miR-135a direct target genes. In human surgical samples from prostatectomy, we observed that miR-135a expression was lower in tumoral compared with paired adjacent normal tissues, mainly in tumors classified with a high Gleason score (⩾8). Moreover, miR-135a expression is lower in invasive tumors, showing extraprostatic extension, as compared with intraprostatic localized tumors. In tumor relative to normal glands, we also showed a more frequently higher ROCK1 protein expression determined using a semi-quantitative immunohistochemistry analysis. Therefore, in tumor cells, the lower miR-135a expression could lead to a higher ROCK1 protein expression, which could explain their invasion abilities. The highlighted relationship between miR-135a expression level and the degree of disease aggressiveness suggests that miR-135a may be considered as a prognostic marker in human PCa.Oncogene advance online publication, 28 July 2014; doi:10.1038/onc.2014.222.
ISSN: 0950-9232

hal-01063902
https://hal.archives-ouvertes.fr/hal-01063902
https://hal.archives-ouvertes.fr/hal-01063902/file/Androgen-regulated%20microRNA-135a.pdf
DOI : 10.1038/onc.2014.222
PUBMED : 25065599

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
In intrauterine pregnancies of uncertain viability with a gestational sac without a yolk sac (with a mean of three orthogonal transvaginal ultrasound measurements <25 mm), the suspected pregnancy loss should only be confirmed after a follow-up scan at least 14 days later shows no embryo with cardiac activity (Grade C). In intrauterine pregnancies of uncertain viability with an embryo <7 mm on transvaginal ultrasound, the suspected pregnancy loss should only be confirmed after a follow-up scan at least 7 days later (Grade C). In pregnancies of unknown location after transvaginal ultrasound (i.e. not visible in the uterus), a threshold of at least 3510 IU/l for the serum human chorionic gonadotrophin assay is recommended; above that level, a viable intrauterine pregnancy can be ruled out (Grade C). Postponing conception after an early miscarriage in women who want a new pregnancy is not recommended (Grade A). A work-up for women with recurrent pregnancy loss should include the following: diabetes (Grade A), antiphospholipid syndrome (Grade A), hypothyroidism with anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-Tg) antibodies (Grade A), vitamin deficiencies (B9, B12) (Grade C), hyperhomocysteinaemia (Grade C), hyperprolactinaemia (Grade B), diminished ovarian reserve (Grade C), and a uterine malformation or an acquired uterine abnormality amenable to surgical treatment (Grade C). The treatment options recommended for women with a missed early miscarriage are vacuum aspiration (Grade A) or misoprostol (Grade B); and the treatment options recommended for women with an incomplete early miscarriage are vacuum aspiration (Grade A) or expectant management (Grade A). In the absence of both chorioamnionitis and rupture of the membranes, women with a threatened late miscarriage and an open cervix, with or without protrusion of the amniotic sac into the vagina, should receive McDonald cerclage, tocolysis with indomethacin, and antibiotics (Grade C). Among women with a threatened late miscarriage and an isolated undilated shortened cervix (<25 mm on ultrasound), cerclage is only indicated for those with a history of either late miscarriage or preterm delivery (Grade A). Among women with a threatened late miscarriage, an isolated undilated shortened cervix (<25 mm on ultrasound) and no uterine contractions, daily treatment with vaginal progesterone up to 34 weeks of gestation is recommended (Grade A). Hysteroscopic section of the septum is recommended for women with a uterine septum and a history of late miscarriage (Grade C). Correction of acquired abnormalities of the uterine cavity (e.g. polyps, myomas, synechiae) is recommended after three early or late miscarriages (Grade C). Prophylactic cerclage is recommended for women with a history of three late miscarriages or preterm deliveries (Grade B). Low-dose aspirin and low-molecular-weight heparin at a preventive dose are recommended for women with obstetric antiphospholipid syndrome (Grade A). Glycaemic levels should be controlled before conception in women with diabetes (Grade A)
ISSN: 0301-2115

hal-01295639
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01295639
DOI : 10.1016/j.ejogrb.2016.02.015
PUBMED : 27039249

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : International audience
Alveolar proteinosis (AP) is a rare disease characterized by alveolar accumulation of surfactant components, which impairs gas exchange. AP is classified into three groups: auto-immune AP defined by the presence of plasma autoantibodies anti-GM-CSF, the most frequent form (90 % of all AP); secondary AP, mainly occurring as a consequence of haematological diseases, or following on from toxic inhalation or infections, and genetic AP, which affects almost exclusively children. AP diagnosis is suspected where chest CT-scan demonstrates interstitial lung disease with a crazy paving aspect; and confirmed by bronchoalveolar lavage, which has a milky appearance and contains periodic acid Schiff positive proteinaceous alveolar deposits. The use of surgical lung biopsy to confirm AP is less frequent nowadays. In this context, positive antibodies against GM-CSF indicates an auto-immune etiology of the AP. Concerning management, whole lung lavage is the gold standard therapy. In refractory AP, new treatments are available such as subcutaneous or inhaled GM-CSF supplementation, or rituximab infusions. The clinical course is unpredictable. Spontaneous improvement or even cure can occur, and the 5-year actuarial survival is 95 %. The most frequent complications are infectious etiology.
La protéinose alvéolaire pulmonaire (PAP) est une maladie rare caractérisée par l’accumulation alvéolaire de composants du surfactant qui gêne les échanges gazeux. Les PAP sont séparées en trois groupes : les PAP auto-immunes caractérisées par la présence d’anticorps sériques anti-GM-CSF qui sont les plus fréquentes ; les PAP secondaires à une maladie sous-jacente, le plus souvent hématologique, mais aussi à l’inhalation de toxiques et à des infections ; enfin, les PAP d’origine génétique. Le diagnostic de PAP est évoqué sur le scanner thoracique avec une pneumopathie infiltrante diffuse ayant un aspect classique de crazy paving, puis confirmé par l’aspect laiteux du lavage bronchoalvéolaire, et la présence de matériel lipoprotéinacé PAS positif. La confirmation du diagnostic de PAP par biopsie pulmonaire chirurgicale est désormais rarement nécessaire. La positivité des anticorps sériques anti-GM-CSF signe le caractère auto-immun de la maladie. Le traitement de référence des PAP auto-immunes est le « grand lavage pulmonaire thérapeutique ». En cas de maladie réfractaire, d’autres traitements sont disponibles, tels que le GM-CSF en injection sous-cutanée ou en aérosol et le rituximab. L’évolution de la maladie est imprévisible. Une évolution spontanément favorable ou même une guérison spontanée peuvent survenir et la survie actuarielle à 5 ans est de 95 %. Les principales complications sont infectieuses.
ISSN: 0761-8425

hal-01085907
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01085907
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01085907/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01085907/file/Prot%C3%A9inose%20alv%C3%A9olaire%20pulmonaire_accepted.pdf
DOI : 10.1016/j.rmr.2014.08.009

Éditeur(s) : HAL CCSD
Résumé : International audience
Island barriers are common features along the world coastlines. They have a crucial role in protecting inland and rich lagoonal ecosystems. Erosion and sand transfers on these island barriers during extreme events such as tropical storms or typhoons remain poorly investigated. This work focuses on a multi-scales nalysis (season to decade) of the morphodynamics of Wan-Tzu-Liao sand barrier subjected to extreme waves and sea surges. We combine topographic measurements of the emerged beach at seasonal scale between 2011 to 2012 and long-term (1993-2009) shoreline changes using aerial photographs and satellite images. At the seasonal scale, during Monsoon, the sand was taken from the beach-front and transported seaward outside the study area. During typhoons season, 12 typhoons drove a beach recovery process resulting in a seaward shoreline shift. This annual behavior is discussed in term of roll-over process of the barrier. At the decadal scale, the shoreline changes evidence cross-shore processes in the north part of the barrier and longshore processes in the south. Although the chronic landward migration displays several stages, the strong losses of the barrier area occurs only since 2004 and call into question the general concept of conservation of mass during the roll-over of a barrier.
Revue Paralia, XIIIème Journées Nationales Génie CIvil Génie Côtier
Dunkerque, France

hal-01018203
https://hal.archives-ouvertes.fr/hal-01018203

Éditeur(s) : HAL CCSD EDP Sciences
Résumé : International audience
This study determined the movements of a Giant Grouper, Epinephelus lanceolatus, in which an acoustictag was surgically implanted and monitored by an array of six VR2W acoustic receiver units from August 2010 toJanuary 2013 in the remote, uninhabited Chesterfield Islands, Coral Sea (800 km West of New Caledonia). Our datarevealed a home reef area (residency rate of 44.9%) with an increased activity revealed by movements at dawn anddusk toward and between two adjacent reef passages, probably for foraging. The fish was absent from its residentreef between October and December 2010 and 2012, corresponding to the time known for spawning aggregationsof this species in New Caledonia. A skipped spawning seems to have occurred in 2011. We hope these data will becomplemented in the future by locating the spawning site or sites and thus provide adequate conservation measures.The Coral Sea links two World Heritage Sites, the Australian Great Barrier Reefs and the New Caledonian coral reefs.It would be fitting to create a Marine Protected Area for the Chesterfield Islands between these two major conservationareas of the sea.
ISSN: 0990-7440

hal-01238809
https://hal-univ-perp.archives-ouvertes.fr/hal-01238809
DOI : 10.1051/alr/2015006

Éditeur(s) : HAL CCSD
Résumé : International audience
The most active deep convection area in the western Mediterranean Sea is located in the Gulf of Lions. Recent studies in this area provides some insights on the complexity of the physical dynamics of convective regions, but very little is known about their impacts on the biogeochemical properties. The CASCADE (CAscading, Surge, Convection, Advection and Downwelling Events) cruise, planed in winter 2011, give us the opportunity to compare vertical profiles of properties sampled either during stratified conditions or after/during a convection event. In the present study, we focus on the distributions of the carbonate system properties (mainly total alkalinity, AT; and total dissolved inorganic carbon, CT) because, in the context of the climate change, deep convection areas are suspected to significantly increase the sequestration of anthropogenic CO2 (CANT). Given its limited size, the impact of the Mediterranean Sea on the global carbon budget is probably minor but this marginal sea can be used as a laboratory to better understand carbon sequestration and its transfer to the basin interior by deep convection processes. Distributions of AT and CT, both measured from bottle samples, and that of CANT (estimated with the TrOCA approach) are first analyzed in the light of other key properties (salinity, temperature, and dissolved oxygen). An objective interpolation procedure is then applied to estimate CT and AT from CTD measured properties. With this procedure, the vertical resolution goes from a maximum of 32 samples per station to one property estimate every meter (more detailed distributions are obtained). Results provide arguments to conclude that CANT is rapidly transferred to the deepest layer due to deep convection events. During deep convection events, the increase of CANT in the water column is positively correlated to that of potential density and oxygen content. The challenge of quantifying the amount of sequestered carbon is however not resolved due to the complexity and the highly dynamical nature of the convective regions. Deep convection in the Gulf of Lions, in parallel with cascading along the continental slope, could thus potentially explain the very high levels of both CANT and acidification estimated in the deep layers of the western Mediterranean Sea.
Deep Sea Research Part I: Oceanographic Research Papers

hal-01336725
https://hal-univ-perp.archives-ouvertes.fr/hal-01336725
DOI : 10.1016/j.dsr.2016.04.003

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The Oman ophiolite, a fossil fast-spreading oceanic ridge had a melt lens perched on top of the magma chamber wherein the gabbro unit was crystallizing. In ophiolites, this melt lens is reduced to a horizon that has been identified in the field. The gabbros that subsided from the lens horizon and drifted out of the magma chamber, while developing a steep magmatic foliation, provide insights into the active melt lens processes. A gabbro, sampled right below the horizon where the lens closed, has virtually not subsided and it offers a direct glance at the floor of the lens. Below, the deeper the gabbros are sampled, the more they have subsided before drifting out of the magma chamber, and the closer they derive from the center of the lens floor. Cross sections in these gabbros record successive events occurring within the lens. In particular, anorthosite layers and lenses that are interlayered within the foliated gabbros record the intrusion of a new melt where plagioclase is the first mineral to crystallize on liquidus. Detailed mapping of anorthosite swarms suggest that melt intrusions are massive, lasting less than 4 yr and that their frequency is similar to 100 yr. Their large volume controls the stability of melt lenses. A new melt surge induces rapid and large inflation of the lens. Melt lens deflation follows, that is due to the ongoing process of crustal accretion both in the gabbro unit by continuous subsidence of a thick gabbroic mush from the lens floor, and in the lid above the lens roof by sheeted dike intrusions feeding basalt extrusions at the higher frequency of similar to 10 yr.
ISSN: 0012-821X

hal-00617444
https://hal.archives-ouvertes.fr/hal-00617444
DOI : 10.1016/j.epsl.2011.01.029

Éditeur(s) : HAL CCSD American Medical Association (AMA)
Résumé : International audience
IMPORTANCE Although frequently used in treating intensive care unit (ICU) patients with sepsis, empirical antifungal therapy, initiated for suspected fungal infection, has not been shown to improve outcome. OBJECTIVE To determine whether empirical micafungin reduces invasive fungal infection (IFI)-free survival at day 28. DESIGN, SETTING, AND PARTICIPANTS Multicenter double-blind placebo-controlled study of 260 nonneutropenic, nontransplanted, critically ill patients with ICU-acquired sepsis, multiple Candida colonization, multiple organ failure, exposed to broad-spectrum antibacterial agents, and enrolled between July 2012 and February 2015 in 19 French ICUs. INTERVENTIONS Empirical treatment with micafungin (100mg, once daily, for 14 days) (n = 131) vs placebo (n = 129). MAIN OUTCOMES AND MEASURES The primary end pointwas survival without proven IFI 28 days after randomization. Key secondary end points included new proven fungal infections, survival at day 28 and day 90, organ failure, serum (1-3)-beta-D-glucan level evolution, and incidence of ventilator-associated bacterial pneumonia. RESULTS Among 260 patients (mean age 63 years; 91 [35%] women), 251 (128, micafungin group; 123, placebo group) were included in the modified intent-to-treat analysis. Median values were 8 for Sequential Organ Failure Assessment (SOFA) score, 3 for number of Candida-colonized sites, and 99 pg/mL for level of (1-3)-beta-D-glucan. On day 28, there were 82 (68%) patients in the micafungin group vs 79 (60.2%) in the placebo group who were alive and IFI free (hazard ratio [HR], 1.35 [95% CI, 0.87-2.08]). Results were similar among patients with a (1-3)-beta-D-glucan level of greater than 80 pg/mL (n = 175; HR, 1.41 [95% CI, 0.85-2.33]). Day-28 IFI-free survival in patients with a high SOFA score (> 8) was not significantly different when compared between the micafungin vs placebo groups (HR, 1.69 [95% CI, 0.96-2.94]). Use of empirical micafungin decreased the rate of new invasive fungal infection in 4 of 128 patients (3%) in the micafungin group vs placebo (15/123 patients [12%]) (P =.008). CONCLUSIONS AND RELEVANCE Among nonneutropenic critically ill patients with ICU-acquired sepsis, Candida species colonization at multiple sites, and multiple organ failure, empirical treatment with micafungin, compared with placebo, did not increase fungal infection-free survival at day 28.
ISSN: 0098-7484

hal-01405822
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01405822
DOI : 10.1001/jama.2016.14655
PUBMED : 27706483

Éditeur(s) : HAL CCSD
Résumé : International audience
Among infertile couples, approximately half have to face with male infertility. In men with non-obstructive azoospermia, surgical retrieval testicular sperm extraction (TESE) of spermatozoa can be attempted, but with low success rates. A specific biomarker that could predict residual spermatogenesis would obviously be of interest before performing TESE. Thus, our aim was to identify biomarkers of residual spermatogenesis in seminal plasma of patients with non-obstructive azoospermia (NOA) using an isotope-coded protein label (ICPL)-based proteomic strategy coupled with conventional protein assay. This retrospective study was conducted in 40 men with NOA at the University Hospital of Nantes and Proteomics Core facility Biogenouest - Inserm U1085 - IRSET, Rennes, France. Comparative ICPL proteomic screening of frozen seminal plasma and correlation with TESE outcome allowed the identification of some differentially expressed proteins. Among them, lectin galactoside-binding, soluble 3 binding protein (LGALS3BP) expression was further confirmed using conventional protein assay, and its interest as a predictor of TESE outcome was then evaluated and compared with conventional clinical and hormonal markers of residual spermatogenesis. Among the 12 differentially expressed proteins identified with comparative ICPL proteomic strategy, seminal LGALS3BP expression was found to be significantly higher in men with successful TESE. Finally, comparative ICPL proteomic screening of seminal plasma appears to be a promising approach for the identification of biomarkers of residual spermatogenesis. LGALS3BP, associated with clinical and hormonal markers, could potentially be used as a predictive marker of successful TESE outcome in patients with NOA.
Andrology

inserm-00818514
http://www.hal.inserm.fr/inserm-00818514
DOI : 10.1111/j.2047-2927.2012.00059.x
PUBMED : 23427166

Éditeur(s) : Université des Antilles Études caribéennes
Résumé : Depuis le passage du cyclone Hugo en 1989, la Guadeloupe est plus ou moins préparée à affronter un nouvel évènement cyclonique (alerte météo, abris anti-cycloniques, etc.). En revanche, pour ce qui concerne les tsunamis, ce n’est que depuis quelques années (après le tsunami de 2004 dans l’océan indien, le séisme de Haïti de 2010 et le tsunami du Japon de 2011) qu’une prise de conscience du risque encouru dans la Caraïbe et plus particulièrement dans l’archipel guadeloupéen s’est faite. Des projets d’évaluation de ces risques ont alors vu le jour et c’est dans le cadre de l’un d’eux (projet INTERREG IV TSUNAHOULE) que l’étude de l’aléa submersion marine pour la réserve naturelle de Petite-Terre a été réalisée. Au travers de 3 scénarios extrêmes choisis en accord avec les connaissances météorologiques et géologiques de la région, les impacts modélisés d’un tsunami, d’une houle de nord longue période et d’un cyclone de catégorie 4-5 sont présentés et discutés distinctement après avoir dressé un bilan des différents enjeux de la réserve, ce qui mène à une réflexion sur la vulnérabilité des occupants de la réserve face à ces aléas naturels.
Since the tropical hurricane Hugo devastated Guadeloupe Archipelago in 1989, the island is more or less prepared to face another cyclonic event (alerts, shelters, etc.). On the other hand, tsunamis have only become a great concern in the Caribbean and more particularly in Guadeloupe for a couple of years (after the 2004 Indian Ocean tsunami, the 2010 Haiti earthquake and the 2011 Japan tsunami). Thus research projects have been led to try to assess marine submersion hazards as the INTERREG IV TSUNAHOULE project in which this study of the natural sanctuary of Petite-Terre has been done. Through 3 extreme scenarios chosen in agreement with meteorological and geological knowledge in the region, the modeled impact of a tsunami, a long period north swell, and a 4-5 category hurricane are presented and discussed separately after having detailed the different stakes of the sanctuary, which leads to start on thought about the vulnerability of its inhabitants, temporary or not, in front of those natural hazards.
Guadeloupe
Petite-Terre

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.6643
http://journals.openedition.org/etudescaribeennes/6643

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
OBJECTIVES: Tracheobronchial stenosis (TBS) is noted in 12-23% of patients with granulomatosis with polyangiitis (GPA), and includes subglottic stenosis and bronchial stenosis. We aimed to analyse the endoscopic management of TBS in GPA and to identify factors associated with the efficacy of endoscopic interventions. METHODS: We conducted a French nationwide retrospective study that included 47 patients with GPA-related TBS. RESULTS: Compared with patients without TBS, those with TBS were younger, more frequently female and had less frequent kidney, ocular and gastrointestinal involvement and mononeuritis multiplex. Endoscopic procedures included 137 tracheal and 50 bronchial interventions, mainly endoscopic dilatation, local steroid injection and conservative laser surgery, and less frequently stenting. After the first endoscopic procedure, the cumulative incidence of endoscopic treatment failure was 49% at 1 year, 70% at 2 years and 80% at 5 years. Factors significantly associated with a higher cumulative incidence of treatment failure were a shorter time from GPA diagnosis to endoscopic procedure [hazard ratio (HR) 1.08 (95% CI 1.01, 1.14); P = 0.01] and a bronchial stenosis [HR 1.96 (95% CI 1.28, 3.00); P = 0.002]. A prednisone dose ≥30 mg/day at the time of the procedure was associated with a lower cumulative incidence of treatment failure [HR 0.53 (95% CI 0.31, 0.89); P = 0.02]. CONCLUSION: TBS represents severe and refractory manifestations with a high rate of restenosis. High-dose systemic CSs at the time of the procedure and increased time from GPA diagnosis to bronchoscopic intervention are associated with a better event-free survival. In contrast, bronchial stenoses are associated with a higher rate of restenosis than subglottic stenosis.
ISSN: 1462-0324

hal-01155105
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01155105
DOI : 10.1093/rheumatology/kev129
PUBMED : 26001634

Éditeur(s) : HAL CCSD
Résumé : In the bay of Aigues-Mortes, the managers of the co astal cities try to preserve the socio-economic and patrimonial stakes against the coastal hazards, such as contamination, storm surge and erosion. In this context, a massive beach nourishment of sand (1 million of m3 for 10km of coastline) was made at the beginning of year 2008 to reduce erosion. The REPBAM project (REchargements et Panaches sédiment aires dans la Baie d'Aigues-Mortes) aims to qualify and quantify by in-situ measurements and numerical modelling: 1. the geomorphological evolution of this modified coast and 2. the impact of the sediment's resuspension on the coastal ecosystems, in particular the one of the Posidonia oceanica seagrass. A numerical modelling "wave/current/sediment" is first implemented for December 2008. Nested and curvilinear grids allow a very high resolution for the beach area but also include the inner shelf where the seagrasses are located. Hydrodynamic and topo-bathymetric measurements were acquired from January to May 2012. Model and measurements results show the same trends during storms: strong currents, seaward migrationof the innerbar, sediment resuspension and turbid on the inner shelf.
Coastal Dynamics 2013
Arcachon, France

hal-00908082
https://hal.archives-ouvertes.fr/hal-00908082

Éditeur(s) : Université des Antilles Études caribéennes
Résumé : Este trabajo propone una lectura interpretativa de la historia urbana y cultural de Mar del Plata, territorio cuyo escenario costero fue intervenido con importantes modificaciones. Ubicados en este contexto de transformación, se indagarán las prácticas publicitarias que contribuyan a la comprensión de las características del sitio, con el fin de ofrecer interpretaciones en torno a los cambios en la construcción de la imagen de la ciudad, las representaciones sociales que las sustentan y los códigos visuales y discursivos usados para su transmisión. Para alcanzar tales objetivos, se analizarán los productores de mensajes; las imágenes y los textos escritos que las acompañan; el enlace entre estas dos instancias y la interpretación que surge de ellas. Por otro lado, entendemos que la recuperación y lectura interpretativa de las piezas gráficas, elaboradas para la promoción de la ciudad, permiten trazar e interpretar los rasgos fundamentales de la transición de un balneario de elite a uno abierto a todos los grupos sociales. Así, el estudio de las sucesivas imágenes de Mar del Plata, resulta una empresa que favorece el estudio de estas huellas visibles, reveladas en las diferentes campañas e impulsadas por las políticas turísticas de los gobiernos y entidades privadas, entre 1930 y 1945.
Cette étude propose une lecture interprétative de l’histoire urbaine et culturelle de Mar del Plata, un territoire dont le paysage côtier a connu d’importances modifications. Dans ce contexte de transformation, l’article étudie les pratiques publicitaires qui contribuent à la compréhension des caractéristiques de cet endroit, dans le but de proposer des interprétations autour des changements dans la construction de l’image de la ville, les représentations sociales qui les supportent, les codes visuels et discursifs utilisés pour les transmettre.Pour atteindre ces objectifs, l’auteur analyse les émetteurs de messages, les images et les textes qui les accompagnent, le lien entre les deux instances, et l’interprétation qui émane d’elles. La récupération et la lecture interprétative de pièces graphiques, élaborées pour promouvoir la ville, permettent d’identifier et d’interpréter les caractéristiques fondamentales de la transition d’une station balnéaire élitiste qui devient une station qui se popularise. Par conséquent, l’étude des images successives de Mar del Plata entre 1930 et 1945 permet de suivre l’évolution de la station à travers les différentes campagnes definies par les politiques touristiques du gouvernement et les entreprises privées.
This work proposes an interpretative reading of the urban and cultural history of Mar del Plata, a territory whose coastal scenery has been modified in a very important way. Once in this transformational context, we will analyse the advertising practices that contribute to understand the characteristics of the area, in order to offer an interpretation of the changes undergone in the construction of the city image, the social representations that support them and the visual and discursive codes used to transmit them.In order to achieve those aims, we are going to analyse the producers of those messages, the images and the written texts that are included in them, the link between both those instances, and their interpretation. On the other hand, we understand that the recuperation and the interpretative reading of the graphic pieces, elaborated to promote the city, allow a better interpretation of the fundamental characteristics of the transition from an élite seaside resort into one open to all social groups. Thus, the study of the successive images of Mar del Plata favours the study of the visible traces, revealed by the different campaigns and encouraged by the tourist policies of the government and private enterprises, between 1930 and 1945.
Mar del Plata
Argentine

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.3729
http://journals.openedition.org/etudescaribeennes/3729

Éditeur(s) : HAL CCSD
Résumé : 32 pages
Wind energy production is very sensitive to instantaneous wind speed fluctuations. Thus rapid variation of wind speed due to changes in the local meteorological conditions can lead to electrical power variations of the order of the nominal power output. In small grids, as they exist for example on some islands in the French West Indies, such fluctuations can cause instabilities in case of intermediate power shortages. To palliate these difficulties, it is essential to identify and characterize the wind speed distributions. This allows to anticipate the eventuality of power shortage or power surge. Therefore, it is of interest to categorize wind speed fluctuations into distinct classes and to estimate the probability of a distribution to belong to a class. This paper presents a method for classifying wind speed histograms by estimating a finite mixture of Dirichlet distributions. The SAEM algorithm that we use provides a fine distinction between wind speed distribution classes. It's a new nonparametric method for wind speed sequences classification. However, we show that the wind speed distributions in each class correspond to specific Gram- Charlier densities.
https://hal.archives-ouvertes.fr/hal-00319608

hal-00319608
https://hal.archives-ouvertes.fr/hal-00319608
https://hal.archives-ouvertes.fr/hal-00319608v2/document
https://hal.archives-ouvertes.fr/hal-00319608/file/Article_dirichlet.pdf
ARXIV : 0810.4422