Éditeur(s) : Society for the Study of Caribbean Ornithology Society for the Study of Caribbean Ornithology ( Camarillo Calif, Camarillo Calif )
Résumé : (Language) In English, with some Spanish.
(Dates or Sequential Designation) Vol. 1, no. 1 (Jan.-Feb. 1988)-
(Dates or Sequential Designation) Ceased in 2002.
(Numbering Peculiarities) Vol. 1, no. 3 covers the period May-Aug. 1988.
(Issuing Body) Newsletter of the Society for the Study of Caribbean Ornithology, Jan/Feb.-Mar./Apr. 1988; the Society of Caribbean Ornithology, May/Aug. 1988-
Editor, 1988- James W. Wiley.
Latest issue consulted: Vol. 15, no. 1 (spring 2002) (Surrogate)
Caribbean Area
Caribbean Area

23284416
sn 99004863
1527-7151

Éditeur(s) : Society for the Study of Caribbean Ornithology Society for the Study of Caribbean Ornithology ( Camarillo Calif, Camarillo, Calif )
Résumé : (Language) In English, with some Spanish.
(Dates or Sequential Designation) Vol. 1, no. 1 (Jan.-Feb. 1988)-
(Dates or Sequential Designation) Ceased in 2002.
(Numbering Peculiarities) Vol. 1, no. 3 covers the period May-Aug. 1988.
(Issuing Body) Newsletter of the Society for the Study of Caribbean Ornithology, Jan/Feb.-Mar./Apr. 1988; the Society of Caribbean Ornithology, May/Aug. 1988-
Editor, 1988- James W. Wiley.
Latest issue consulted: Vol. 15, no. 1 (spring 2002) (Surrogate)
Caribbean Area
Caribbean Area

23284416
sn 99004863
1527-7151

Éditeur(s) : Society for the Study of Caribbean Ornithology Society for the Study of Caribbean Ornithology ( Camarillo, Calif. )
Résumé : (Language) In English, with some Spanish.
(Dates or Sequential Designation) Vol. 1, no. 1 (Jan.-Feb. 1988)-
(Dates or Sequential Designation) Ceased in 2002.
(Numbering Peculiarities) Vol. 1, no. 3 covers the period May-Aug. 1988.
(Issuing Body) Newsletter of the Society for the Study of Caribbean Ornithology, Jan/Feb.-Mar./Apr. 1988; the Society of Caribbean Ornithology, May/Aug. 1988-
Editor, 1988- James W. Wiley.
Latest issue consulted: Vol. 15, no. 1 (spring 2002) (Surrogate)
Caribbean Area
Caribbean Area

23284416
sn 99004863
1527-7151

Éditeur(s) : Society for the Study of Caribbean Ornithology Society for the Study of Caribbean Ornithology ( Camarillo, Calif. )
Résumé : (Language) In English, with some Spanish.
(Dates or Sequential Designation) Vol. 1, no. 1 (Jan.-Feb. 1988)-
(Dates or Sequential Designation) Ceased in 2002.
(Numbering Peculiarities) Vol. 1, no. 3 covers the period May-Aug. 1988.
(Issuing Body) Newsletter of the Society for the Study of Caribbean Ornithology, Jan/Feb.-Mar./Apr. 1988; the Society of Caribbean Ornithology, May/Aug. 1988-
Editor, 1988- James W. Wiley.
Latest issue consulted: Vol. 15, no. 1 (spring 2002) (Surrogate)
Caribbean Area
Caribbean Area

23284416
sn 99004863
1527-7151

Éditeur(s) : Society for the Study of Caribbean Ornithology Society for the Study of Caribbean Ornithology ( Camarillo Calif, Camarillo, Calif )
Résumé : (Language) In English, with some Spanish.
(Dates or Sequential Designation) Vol. 1, no. 1 (Jan.-Feb. 1988)-
(Dates or Sequential Designation) Ceased in 2002.
(Numbering Peculiarities) Vol. 1, no. 3 covers the period May-Aug. 1988.
(Issuing Body) Newsletter of the Society for the Study of Caribbean Ornithology, Jan/Feb.-Mar./Apr. 1988; the Society of Caribbean Ornithology, May/Aug. 1988-
Editor, 1988- James W. Wiley.
Latest issue consulted: Vol. 15, no. 1 (spring 2002) (Surrogate)
Caribbean Area
Caribbean Area

23284416
sn 99004863
1527-7151

Éditeur(s) : Society for the Study of Caribbean Ornithology Society for the Study of Caribbean Ornithology ( Camarillo Calif, Camarillo Calif )
Résumé : (Language) In English, with some Spanish.
(Dates or Sequential Designation) Vol. 1, no. 1 (Jan.-Feb. 1988)-
(Dates or Sequential Designation) Ceased in 2002.
(Numbering Peculiarities) Vol. 1, no. 3 covers the period May-Aug. 1988.
(Issuing Body) Newsletter of the Society for the Study of Caribbean Ornithology, Jan/Feb.-Mar./Apr. 1988; the Society of Caribbean Ornithology, May/Aug. 1988-
Editor, 1988- James W. Wiley.
Latest issue consulted: Vol. 15, no. 1 (spring 2002) (Surrogate)
Caribbean Area
Caribbean Area

23284416
sn 99004863
1527-7151

Éditeur(s) : HAL CCSD Wiley
Résumé : A standardized rapid inventory method providing information on both tree species diversity and aboveground carbon stocks in tropical forests will be an important tool for evaluating efforts to conserve biodiversity and to estimate the carbon emissions that result from deforestation and degradation (REDD). Herein, we contrast five common plot methods differing in shape, size, and effort requirements to estimate tree diversity and aboveground tree biomass (AGB). We simulated the methods across six Neotropical forest sites that represent a broad gradient in forest structure, tree species richness, and floristic composition, and we assessed the relative performance of methods by evaluating the bias and precision of their estimates of AGB and tree diversity. For a given sample of forest area, a several small' (<1ha) sampling strategy led to a smaller coefficient of variation (CV) in the estimate of AGB than a few large' one. The effort (person-days) required to achieve an accurate AGB estimate (<10% CV), however, was greater for the smallest plots (0.1ha) than for a compromise approach using 0.5ha modified Gentry plots, which proved to be the most efficient method to estimate AGB across all forest types. Gentry plots were also the most efficient at providing accurate estimates of tree diversity (<10% CV of Hill number). We recommend the use of the 0.5ha modified Gentry plot method in future rapid inventories, and we discuss a set of criteria that should inform any choice of inventory method.
ISSN: 0006-3606

hal-01032408
https://hal.archives-ouvertes.fr/hal-01032408
DOI : 10.1111/btp.12006

Éditeur(s) : HAL CCSD Wiley-Blackwell
Résumé : International audience
This paper aims to decipher the thermal evolution of the Montagne Noire Axial Zone (MNAZ,southern French Massif Central) gneiss core and its metasedimentary cover through determination ofP–T paths and temperature gradients. Migmatitic gneiss from the core of the dome record a clock-wise evolution culminating at 725 25 °C and 0.8 0.1 GPa with partial melting, followed by adecompression path with only minor cooling to 690 25° C and 0.4 0.1 GPa. Field structuralanalyses as well as detailed petrological observations interpreted in a petrogenetic grid indicate thatthe cover sequence experienced LP-HT metamorphism at <0.4 GPa. Apparent thermal gradientswithin the cover were determined with garnet–biotite thermometry and Raman Spectroscopy on Car-bonaceous Matter. High-temperature apparent gradients (e.g. 530 °C km1 along one transect) areexplained by late brittle–ductile extensional shearing evidenced by phyllonites that post-date peakmetamorphism. In areas where normal faults are less abundant and closely spaced, gradients of 20to 50 °C km1 are calculated. These gradients can be accounted for by a combination of domeemplacement and ductile shearing (collapse of isotherms), without additional heat input. Finally, thethermal evolution of the MNAZ is typical for many gneiss domes worldwide as well as with otherLP-HT terranes in the Variscides.
ISSN: 0263-4929

Droits : http://creativecommons.org/licenses/by-nc-nd/
insu-01290388
https://hal-insu.archives-ouvertes.fr/insu-01290388
https://hal-insu.archives-ouvertes.fr/insu-01290388/document
https://hal-insu.archives-ouvertes.fr/insu-01290388/file/jmg12188.pdf
DOI : 10.1111/jmg.12188

Éditeur(s) : Wiley-blackwell Publishing, Inc
Résumé : Vibrio splendidus, strain LGP32, is an oyster pathogen associated with the summer mortalities affecting the production of Crassostrea gigas oysters worldwide. Vibrio splendidus LGP32 was shown to resist to up to 10 mu M Cg-Def defensin and Cg-BPI bactericidal permeability increasing protein, two antimicrobial peptides/proteins (AMPs) involved in C. gigas immunity. The resistance to both oyster Cg-Def and Cg-BPI and standard AMPs (polymyxin B, protegrin, human BPI) was dependent on the ompU gene. Indeed, upon ompU inactivation, minimal bactericidal concentrations decreased by up to fourfold. AMP resistance was restored upon ectopic expression of ompU. The susceptibility of bacterial membranes to AMP-induced damages was independent of the ompU-mediated AMP resistance. Besides its role in AMP resistance, ompU proved to be essential for the adherence of V. splendidus LGP32 to fibronectin. Interestingly, in vivo, ompU was identified as a major determinant of V. spiendidus pathogenicity in oyster experimental infections. Indeed, the V. splendidus-induced oyster mortalities dropped from 56% to 11% upon ompU mutation (Kaplan Meier survival curves, P < 0.01). Moreover, in co-infection assays, the ompU mutant was out competed by the wild-type strain with competitive indexes in the range of 0.1-0.2. From this study, ompU is required for virulence of V. splendidus. Contributing to AMP resistance, conferring adhesive properties to V. splendidus, and being essential for in vivo fitness, the OmpU porin appears as an essential effector of the C. gigas/V. splendidus interaction.
Environmental Microbiology (1462-2912) (Wiley-blackwell Publishing, Inc), 2010-04 , Vol. 12 , N. 4 , P. 951-963

Droits : 2010 Society for Applied Microbiology and Blackwell Publishing Ltd
http://archimer.ifremer.fr/doc/00003/11421/8044.pdf
DOI:10.1111/j.1462-2920.2009.02138.x
http://archimer.ifremer.fr/doc/00003/11421/

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
Background: Squamous cell carcinoma (SCC) is considered the most frequent skin cancer in black people. Its incidence is not known in the Afro-Caribbean population.Objective: To assess the incidence of SCC in Guadeloupe, the largest island of the Lesser Antilles (405 000 inhabitants, mostly black people of African and European descent). The second objective was to characterize clinical and histological patterns of SCC occurring in the Afro-Caribbean community.Methods: This retrospective study was conducted over an 11-year period (2000-2010). Data regarding 723 histological confirmed cases of SCC identified using the three Guadeloupean pathology laboratories computerized databases were retrieved from the records of 551 patients. Private practice dermatologists and general practitioners were contacted to obtain any missing data. Results: The annual age-adjusted incidence of SCC was 15 per 100.000 residents in Guadeloupe. In the Afro-Caribbean community, SCC had a greater size (i.e.: 2.8±2.8 cm versus 1.5±1.0 cm, p<0.001), was more often located on the anogenital area (i.e. :48/79-60.8% versus 14/320-4.4%, p<0.001) in association with an underlying dermatosis due to HPV infection (15/71- 21.1% versus 3/366, 0.8%, p<0.001) and led more frequently to metastasis (13/84-15.5% versus 10/366-2.7%, p<0.001) and/or fatal evolution (11/83-13.3% versus 7/365-1.9%, p<0.001). Conclusions: The results of this original study, which first estimated the incidence of SCC in West Indies, suggest that anogenital examination should be routinely performed in skin cancer screening of Afro-Caribbean people in order to detect the presence of SCC at an early stage.
ISSN: 0926-9959

inserm-01513116
http://www.hal.inserm.fr/inserm-01513116
http://www.hal.inserm.fr/inserm-01513116/document
http://www.hal.inserm.fr/inserm-01513116/file/2017%2C%20Cordel%20-%20Squamous%20cell%20carcinoma%20in%20the%20Afro-Caribbean%20community.pdf
http://www.hal.inserm.fr/inserm-01513116/file/CordeletalJ%20Eur%20Acad%20Dermatol%20Venereol2017.pdf

Éditeur(s) : HAL CCSD Wiley
Résumé : SUBSURF
International audience
Similarity of form between subaerial and submarine landscapes affected by erosion could suggest similarities in the process of erosion, such as by runoff and sedimentary flows, respectively. On the other hand, if aspects of form vary, its characteristics may be used to identify the environmental origin of erosion. Towards these goals, this contribution addresses the morphology of submarine volcanoes (seamounts) with widely differing histories of erosion. One set from the Pacific Ocean never exposed above sea level includes Cretaceous-age seamounts near Hawai'i (including Apu'upu'u Seamount), two seamounts of < 3 Ma in age near a mid-ocean ridge and the 11-4 Ma Jasper Seamount. These seamounts are all isolated from continents and hence from any erosion associated with mass wasting of unstable terrigenous deposits. In such isolated submarine environments, surfaces erode slowly from in situ weathering, mass wasting and scouring by sedimentary flows initiated by slope failure in pelagic or bedrock materials. The Pacific seamounts are compared with Valencia Seamount in the western Mediterranean, exposed subaerially for 100-400 k.y. during the Messinian Salinity Crisis before 5 Ma. Multibeam and deeply towed sidescan sonar data of Valencia Seamount reveal features typical of subaerial erosion of volcanic islands, such as canyons and relatively uneroded sectors (planezes) between them. Using a simple topographical reconstruction, the apparent erosion depth typically reaches 100 m within canyons and up to 180 m in places. Whereas the younger Pacific seamounts do not show these erosional features, the much older Cretaceous seamounts do have channels, which in one example suggests up to 200 m of incision. Both Valencia and Apu'upu'u seamounts have channel longitudinal profiles that are steep and typically linear to concave upwards. The erosion depth of Apu'upu'u Seamount is significant, despite the seamount's persistent submarine environment, because of its greater age, steeper flanks and greater contributing areas to channels compared with Valencia Seamount. These results illustrate that the channel morphology resulting from submarine erosion can become similar to that produced by subaerial erosion given sufficient time.
ISSN: 0950-091X

hal-00411425
https://hal.archives-ouvertes.fr/hal-00411425
DOI : 10.1111/j.1365-2117.2008.00355.x

Éditeur(s) : Wiley-blackwell
Résumé : The reef fauna connectivity of the West Indian Ocean (WIO) is one of the least studied globally. Here we use genetic analyses of the grouper Epinephelus merra (Bloch 1793) to determine patterns of connectivity and to identify barriers to dispersal in this WIO marine area. Phylogeographic and population-level analyses were conducted on cytochrome b sequences and microsatellites (13 loci) from 557 individuals sampled in 15 localities distributed across the West Indian Ocean. Additional samples from the Pacific Ocean were used to benchmark the WIO population structure. The high level of divergence revealed between Indian and Pacific localities (of about 4.5% in sequences) might be the signature of the major tectonic and climatic changes operating at the Plio-Pleistocene transition, congruently with numerous examples of Indo-Pacific speciation. In comparison, the E. merra sequences from the Indian Ocean constitute a monophyletic clade with a low average genetic distance (d < 0.5%). However both genetic markers indicated some structure within this ocean. The main structure revealed was the isolation of the Maldives from the WIO localities (a different group signature identified by clustering analysis, great values of differentiation). Both marker types reveal further significant structure within the WIO, mainly the isolation of the Mascarene Islands (significant AMOVA and isolation-by-distance patterns) and some patchy structure between the northernmost localities and within the Mozambique Channel. The WIO genetic structure of E. merra appeared congruent with main biogeographic boundaries and oceanographic currents.
Marine Ecology-an Evolutionary Perspective (0173-9565) (Wiley-blackwell), 2015-09 , Vol. 36 , N. 3 , P. 447-461

Droits : 2014 Blackwell Verlag GmbH
http://archimer.ifremer.fr/doc/00189/30046/28566.pdf
DOI:10.1111/maec.12153
http://archimer.ifremer.fr/doc/00189/30046/

Éditeur(s) : Society for the Study of Caribbean Ornithology Society for the Study of Caribbean Ornithology ( Camarillo Calif, Camarillo, Calif )
Résumé : (Language) In English, with some Spanish.
(Dates or Sequential Designation) Vol. 1, no. 1 (Jan.-Feb. 1988)-
(Dates or Sequential Designation) Ceased in 2002.
(Numbering Peculiarities) Vol. 1, no. 3 covers the period May-Aug. 1988.
(Issuing Body) Newsletter of the Society for the Study of Caribbean Ornithology, Jan/Feb.-Mar./Apr. 1988; the Society of Caribbean Ornithology, May/Aug. 1988-
Editor, 1988- James W. Wiley.
Latest issue consulted: Vol. 15, no. 1 (spring 2002) (Surrogate)
Caribbean Area
Caribbean Area

23284416
sn 99004863
1527-7151

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
BACKGROUND: This study examines gene-environment interaction between the MTHFR C667T polymorphism and folic acid in the etiology of orofacial clefts (OFC). We used a pooled-analytical approach on four studies that used similar methods. METHODS: We used logistic regression to analyze the pooled sample of 1149 isolated cases and 1161 controls. Fetal and maternal MTHFR C677T genotypes, and maternal periconceptional exposure to smoking, alcohol, vitamin containing folic acid and folic acid supplements were contrasted between the cleft types [non-syndromic clefts lip or without cleft palate (CL(P)) and non-syndromic cleft palate (CP)] and control groups. RESULTS: There was a reduced risk of CL(P) with maternal folic acid use (p = 0.008; OR = 0.70, 95% CI: 0.65-0.94) and with supplements containing folic acid (p = 0.028, OR = 0.80, 95% CI: 0.65-0.94). Maternal smoking increased the risk of both CL(P) (p < 10 e-3; OR = 1.62, 95% CI: 1.35-1.95) and CP (p = 0.028; OR = 1.38, 95% CI: 1.04-1.83). No significant risk was observed with either maternal or fetal MTHFR C677T genotypes. CONCLUSION: This individual participant data (IPD) meta-analysis affords greater statistical power and can help alleviate the problems associated with aggregate-level data-sharing. The result of this IPD meta-analysis is consistent with previous reports suggesting that folic acid and smoking influence OFC outcomes.
ISSN: 1542-0752

hal-00875899
https://hal.archives-ouvertes.fr/hal-00875899
DOI : 10.1002/bdra.23133
PUBMED : 23670871

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
BACKGROUND: African Americans with head and neck squamous cell carcinoma (HNSCC) have a lower survival rate than whites. This study investigated the functional importance of ancestry-informative single-nucleotide polymorphisms (SNPs) in HNSCC and also examined the effect of functionally important genetic elements on racial disparities in HNSCC survival. METHODS: Ancestry-informative SNPs, RNA sequencing, methylation, and copy number variation data for 316 oral cavity and laryngeal cancer patients were analyzed across 178 DNA repair genes. The results of expression quantitative trait locus (eQTL) analyses were also replicated with a Gene Expression Omnibus (GEO) data set. The effects of eQTLs on overall survival (OS) and disease-free survival (DFS) were evaluated. RESULTS: Five ancestry-related SNPs were identified as cis-eQTLs in the DNA polymerase beta (POLB) gene (false discovery rate [FDR]<0.01). The homozygous/heterozygous genotypes containing the African allele showed higher POLB expression than the homozygous white allele genotype (P<.001). A replication study using a GEO data set validated all 5 eQTLs and also showed a statistically significant difference in POLB expression based on genetic ancestry (P=.002). An association was observed between these eQTLs and OS (P<.037; FDR<0.0363) as well as DFS (P=.018 to.0629; FDR<0.079) for oral cavity and laryngeal cancer patients treated with platinum-based chemotherapy and/or radiotherapy. Genotypes containing the African allele were associated with poor OS/DFS in comparison with homozygous genotypes harboring the white allele. CONCLUSIONS: Analyses show that ancestry-related alleles could act as eQTLs in HNSCC and support the association of ancestry-related genetic factors with survival disparities in patients diagnosed with oral cavity and laryngeal cancer. (C) 2016 American Cancer Society.
ISSN: 0008-543X

hal-01519253
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01519253
DOI : 10.1002/cncr.30457
PUBMED : 27906459

Éditeur(s) : HAL CCSD Wiley-Blackwell
Résumé : International audience
The Lanzo peridotite massif is a fragment of oceanic lithosphere generated in an ocean-continent transition context and eclogitized during alpine collision. Despite the subduction history, the massif has preserved its sedimentary oceanic cover, suggesting that it may have preserved its oceanic structure. It is an exceptional case for studying the evolution of a fragment of the lithosphere from its oceanization to its subduction and then exhumation. We present a field and petrological study retracing the different serpentinization episodes and their impact on the massif structure. The Lanzo massif is composed of slightly serpentinized peridotites (<20% serpentinization) surrounded by an envelope of foliated serpentinites (100% serpentinization) bordered by oceanic metabasalts and metasedimentary rocks. The limit between peridotites and serpentinites defines the front of serpentinization. This limit is sharp: it is marked by the presence of massive serpentinites (80% serpentinization) and, locally, by dykes of metagabbros and mylonitic gabbros. The deformation of these gabbros is contemporaneous with the emplacement of the magma. The presence of early lizardite in the peridotites testifies that serpentinization began during the oceanization, which is confirmed by the presence of meta-ophicarbonates bordering the foliated serpentinite envelope. Two additional generations of serpentine occur in the ultramafic rocks. The first is a prograde antigorite that partially replaced the lizardite and the relict primary minerals of the peridotite during subduction, indicating that serpentinization is an active process at the ridge and in the subduction zone. Locally, this episode is followed by the deserpentinization of antigorite at peak P-T (estimated in eclogitized metagabbros at 2-2.5 GPa and 550-620 °C): it is marked by the crystallization of secondary olivine associated with chlorite and/or antigorite and of clinopyroxene, amphibole and chlorite assemblages. A second antigorite formed during exhumation partially to completely obliterating previous textures in the massive and foliated serpentinites. Serpentinites are an important component of the oceanic lithosphere generated in slow to ultraslow spreading settings, and in these settings, there is a serpentinization gradient with depth in the upper mantle. The seismic Moho limit could correspond to a serpentinization front affecting the mantle. This partially serpentinized zone constitutes a less competent level where, during subduction and exhumation, deformation and fluid circulation are localized. In this zone, the reaction kinetics are increased and the later steps of serpentinization obliterate the evidence of this progressive zone of serpentinization. In the Lanzo massif, this zone fully recrystallized into serpentinite during alpine subduction and collision. Thus, the serpentinite envelope represents the oceanic crust as defined by geophysicists, and the sharp front of serpentinization corresponds to an eclogitized seismic palaeo-Moho.
ISSN: 0263-4929

hal-00823051
https://hal.archives-ouvertes.fr/hal-00823051
DOI : 10.1111/jmg.12008

Éditeur(s) : Wiley-blackwell Publishing, Inc
Résumé : Oceanic larvae of the European (Anguilla anguilla) and American (A. rostrata) eels have to cross the Atlantic Ocean from the Sargasso Sea to European or North American coasts before entering continental habitats. In some European rivers, eel recruitment is now < 1% of levels in the 1980s. A better understanding of the effects of anthropogenic pressures and environmental fluctuations on eel larvae and subsequent recruitment is a prerequisite to build efficient management plans. The present paper provides insight into the critical oceanic phase of the eel life cycle with a focus on the duration of the larval migration whose estimates varies between 7 months and more than 2 years in both species. Does this range correspond to a natural variability in larval duration or does it stem from methodological artefacts? We first review the different methods used to estimate the duration of larval migration and critically describe their possible sources of misinterpretation. We then evaluate the consistency of these methods with the current knowledge about the ecology and physiology of eel larvae and the physical oceanography. While a moderate discrepancy in migration duration was found between methods for the American eel, the discrepancy was large in the European eel. In this species, otolith microstructure studies indicated migration durations between 7 and 9 months, while other methods pointed to durations of about 2 years. We show that estimates in favour of a long migration duration seem more robust to methodological caveats than methods estimating short durations of migration.
Fish And Fisheries (1467-2960) (Wiley-blackwell Publishing, Inc), 2010-09 , Vol. 11 , N. 3 , P. 289-306

Droits : 2010 Blackwell Publishing Ltd.
http://archimer.ifremer.fr/doc/00011/12208/9033.pdf
DOI:10.1111/j.1467-2979.2010.00362.x
http://archimer.ifremer.fr/doc/00011/12208/

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
Two genome-wide association studies (GWASs) recently highlighted the HLA-DRA and HLA-DRB5 genes as associated with Parkinson disease (PD). However, because HLA-DRA displays a low level of polymorphisms and HLA-DRB5 is only present in approximately 20% of the population, these findings are difficult to interpret. Our aims were: (1) to replicate and investigate in greater detail the association between PD and the HLA-DR region; (2) to identify PD-associated HLA alleles; and (3) to perform a meta-analysis of our top finding. As part of 2 French population-based case-control studies of PD including highly ethnically homogeneous participants, we investigated the association between PD and 51 Single-nucleotide polymorphisms (SNPs) in the HLA-DR region. HLA-DRB1 alleles were imputed using the HLA(*) IMP software. HLA typing was performed in a subsample of the participants. We performed a meta-analysis of our top finding based on 4 GWAS data sets. Among 499 cases and 1123 controls, after correction for multiple testing, we found an association with rs660895 (OR/minor allele, 0.70; 95% CI, 0.57-0.87) within the HLA-DRB1 gene, which encodes the most polymorphic HLA-DR chain (DRβ). A meta-analysis (7996 cases, 36455 controls) confirmed this association (OR, 0.86; 95% CI, 0.82-0.91; P < .0001). SNP-based imputation of HLA alleles showed an inverse association between PD and the HLA-DRB1(*) 04 allele. We replicated an association between PD and the HLA-DR region and provided further insight into the loci and alleles involved. The highly polymorphic HLA-DRB1 locus contains rs660895, which represents a more legitimate candidate than previous ones. Our finding is in agreement with the hypothesis of an immune component in PD pathophysiology. © 2012 Movement Disorder Society.
ISSN: 0885-3185

inserm-00721562
http://www.hal.inserm.fr/inserm-00721562
http://www.hal.inserm.fr/inserm-00721562/document
http://www.hal.inserm.fr/inserm-00721562/file/Table1.pdf
http://www.hal.inserm.fr/inserm-00721562/file/Table2.pdf

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
BACKGROUND: Recent studies suggest that a Mediterranean dietary pattern during pregnancy may influence pregnancy outcomes. The aim of this study was to evaluate the effect of adherence to a Mediterranean diet (MD) during pregnancy on fetal growth restriction (FGR) and preterm delivery (PTD) in a French Caribbean island where the population is largely of African descent and presents dietary patterns similar to MD. METHODS: Using data from the TIMOUN Mother-Child Cohort Study conducted in Guadeloupe (French West Indies) between 2004 and 2007, we analysed data for 728 pregnant women who delivered liveborn singletons without any major congenital malformations. Degree of adherence to MD during pregnancy was evaluated with a semi-quantitative food frequency questionnaire based on nine dietary criteria. Multiple logistic regression models were used to analyse birth outcomes while taking potential confounders into account. RESULTS: Overall there was no association between MD adherence during pregnancy and the risk of PTD or FGR. However, pre-pregnancy body mass index was a strong effect modifier, and MD adherence was associated with a decreased risk of PTD specifically in overweight and obese women (adjusted odds ratio 0.7, 95% confidence interval 0.6, 0.9) (P heterogeneity <0.01). CONCLUSIONS: These results suggest that Caribbean diet during pregnancy may carry some benefits of MD and may contribute to reduce the risk of PTD in overweight and obese pregnant women.
ISSN: 0269-5022

hal-00988172
https://hal-univ-rennes1.archives-ouvertes.fr/hal-00988172
DOI : 10.1111/ppe.12113
PUBMED : 24754337

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
A nested case-control association study was designed to investigate the influence of maternal and fetal copy number variants (CNVs) on reproductive outcomes. Genotypes of ten CNVs encompassing GST and CYP genes were assessed. Significant associations were only found for child CNV genotypes. In particular, the child GSTM1 insertion allele was associated with prematurity protection (odds ratio, 95% CI: 0.67, 0.51-0.89; P < 0.01), whereas the child GSTT2B insertion allele was associated with an increased risk of being small for gestational age (odds ratio, 95% CI: 1.33, 1.07-1.67; P = 0.01). The study highlights the role of the fetal genome in prenatal development and also the need to analyse CNVs in a systematic manner.
ISSN: 1470-0328

hal-00875955
https://hal.archives-ouvertes.fr/hal-00875955
DOI : 10.1111/j.1471-0528.2012.03400.x
PUBMED : 22676722