Éditeur(s) : Monachii ; Lipsiae : apud R. Oldenbourg in comm.
Extrait de : Flora brasiliensis : enumeratio plantarum in Brasilia hactenus detectarum quas suis aliorumque botanicorum studiis descriptas et methodo naturali digestas partim icone illustratas
Résumé : Édition : 1840-1906
Siècle(s) traité(s) : 19
Droits : Domaine public
Provenance : Université Toulouse III - Paul Sabatier. Service Commun de la Documentation
Permalien : http://www.manioc.org/patrimon/TLS17055
TLS17055

Éditeur(s) : HAL CCSD
Résumé : International audience
Les recherches conduites dans le secteur du tourisme sont rapidement confrontées au manque d'éléments statistiques. Des enquêtes sont réalisées au niveau national et de multiples études sont effectuées sur des micro-régions, mais entre ces deux niveaux, l'activité touristique souffre d'une carence statistique.L'une des premières approches de l'activité touristique consiste à quantifier la fréquentation d'un espace donné (une région administrative, un département, une zone touristique). Les résultats actuellement disponibles sont obtenus à partir de méthodes diversifiées, leurs qualités inégales rendent toues comparaisons d'un espace à un autre extrêmement délicates. A partir d'un recensement des méthodes les plus classiques accompagnées d'applications réalisées au sein d'observatoires du tourisme, nos investigations vont s'étendre sur une approche nouvelle, "la méthode des flux" dont l'utilisation se généralise sur l'ensemble des régions méridionales de l'espace national.
Géo-Centre-Ouest, Poitiers

hal-01405840
https://hal.univ-antilles.fr/hal-01405840
https://hal.univ-antilles.fr/hal-01405840/document
https://hal.univ-antilles.fr/hal-01405840/file/1995%20l%27evaluation%20de%20la%20fr%C3%A9quentation%20touristique.pdf

Éditeur(s) : HAL CCSD Université des Antilles
Résumé : International audience
ISSN: 1779-0980

hal-01624730
https://hal.archives-ouvertes.fr/hal-01624730
DOI : 10.4000/etudescaribeennes.613

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The objective of the study was to evaluate the distribution of methotrexate (MTX) in cerebrospinal fluid (CSF) lateral ventricles and in cisterna magna after 3rd intraventricular CSF administration in a rabbit model.MTX or gadolinium chelate (Gd-DOTA) was administered in the 3rd ventricle with a local microdialysis to study the pharmacokinetics at the site of administration and with a simultaneous magnetic resonance imaging (MRI) acquisition in the 3rd ventricle, the lateral ventricles and in the cisterna magna. A specific CSF Physiologically Based Pharmacokinetic (PBPK) model was then extrapolated for MTX from Gd-DOTA data.The relative contribution of elimination and distribution processes to the overall disposition of MTX and Gd-DOTA in the 3rd ventricle was similar (i.e., around 60% for CLE and 40% for CLI) suggesting that Gd-DOTA was a suitable surrogate marker for MTX disposition in ventricular CSF. The PBPK predictions for MTX both in CSF of the 3rd ventricle and in plasma were in accordance with the in vivo results.The present study showed that the combination of local CSF microdialysis with MRI acquisition of the brain ventricles and a PBPK model could be a useful methodology to estimate the drug diffusion within CSF ventricles after direct brain CSF administration. Such a methodology would be of interest to clinicians for a rationale determination and optimization of drug dosing parameters in the treatment of leptomeningeal metastases.
ISSN: 0939-6411

hal-01335562
https://hal.archives-ouvertes.fr/hal-01335562
https://hal.archives-ouvertes.fr/hal-01335562/document
https://hal.archives-ouvertes.fr/hal-01335562/file/PBPK%20model%20of%20methotrexate%20in%20cerebrospinal%20fluid.pdf
DOI : 10.1016/j.ejpb.2016.04.012

Éditeur(s) : HAL CCSD
Résumé : International audience
La Caraïbe, Cuba et les enjeux de la mondialisation : expériences nationales et coopérations régionales
La Havana, Cuba

hal-01634309
https://hal.archives-ouvertes.fr/hal-01634309

Éditeur(s) : HAL CCSD Université des Antilles
Résumé : International audience
Considering the increasing importance of the tourist mobilities worldwide, the questioning on the interrelationships between tourism and natural resources is more current more than ever. Tourism is a powerful vehicle of territory transformations which must be comprehended though flows, practices, consumptions. It means taking of the complexity of tourist system and of identifiyng the economic, social and environmental stakes linked to the use and the exploitation of the biodiversity by this activity.
Le questionnement sur les interactions entre le tourisme et les ressources naturelles est plus que jamais d’actualité compte tenu de l’importance croissante des mobilités touristiques à travers le monde. Le tourisme est un puissant vecteur de transformation du territoire qui doit être appréhendé à travers les flux, les pratiques, les consommations. Il s’agit de prendre la mesure de la complexité du système touristique et d’identifier les enjeux économiques, sociaux et environnementaux liés à l’utilisation et l’exploitation de la biodiversité par cette activité.
ISSN: 1779-0980

Droits : http://creativecommons.org/licenses/by-nc/
hal-01625317
https://hal.archives-ouvertes.fr/hal-01625317

Éditeur(s) : HAL CCSD Université des Antilles
Résumé : International audience
The development of the small island territories is often approached under the angle of the vulnerability, the limits and other handicaps which penalize inevitably their growth perspectives. However, it is noticed that some islands display nowadays among the most prosperous economies to the world. The object of this reflection is to propose a frame to study the small islands, the evolution of their positioning and trajectories of development. It’s interesting to see how small islands, with their different political statuses and economic dependences, manage their development in the globalized economy by using conveniently their peculiarity.
Le développement des petits territoires insulaires est souvent abordé sous l'angle de la vulnérabilité, des limites et autres handicaps qui pénalisent inéluctablement leurs perspectives de croissance. Or force est de constate que quelques îles s’affichent désormais parmi les économies les plus prospères au monde. L’objet de cette réflexion est de proposer un cadre pour étudier les petites îles, appréhender l’évolution de leurs positionnements et leurs trajectoires de développement. Il s’agit de voir dans quelle mesure ces petites îles, aux statuts juridiques variables et dépendantes sur le plan économique, peuvent opportunément tirer profit de leur situation – parfois en jouant sur leur singularité- pour se positionner avantageusement dans la configuration actuelle de l’économie mondialisée.
ISSN: 1779-0980

hal-01624763
https://hal.archives-ouvertes.fr/hal-01624763
DOI : 10.4000/etudescaribeennes.7250

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
In contrast to mammals that have limited proliferation and neurogenesis capacities, the Xenopus frog exhibit a great potential regarding proliferation and production of new cells in the adult brain. This ability makes Xenopus a useful model for understanding the molecular programs required for adult neurogenesis. Transcriptional factors that control adult neurogenesis in vertebrate species undergoing widespread neurogenesis are unknown. NeuroD1 is a member of the family of proneural genes, which function during embryonic neurogenesis as a potent neuronal differentiation factor. Here, we study in detail the expression of NeuroD1 gene in the juvenile and adult Xenopus brains by in situ hybridization combined with immunodetections for proliferation markers (PCNA, BrdU) or in situ hybridizations for cell type markers (Vimentin, Sox2). We found NeuroD1 gene activity in many brain regions, including olfactory bulbs, pallial regions of cerebral hemispheres, preoptic area, habenula, hypothalamus, cerebellum and medulla oblongata. We also demonstrated by double staining NeuroD1/BrdU experiments, after long post-BrdU administration survival times, that NeuroD1 gene activity was turned on in new born neurons during post-metamorphic neurogenesis. Importantly, we provided evidence that NeuroD1-expressing cells at this brain developmental stage were post-mitotic (PCNA-) cells and not radial glial (Vimentin+) or progenitors (Sox2+) cells.
ISSN: 1932-6203

hal-00877023
https://hal-univ-rennes1.archives-ouvertes.fr/hal-00877023
https://hal-univ-rennes1.archives-ouvertes.fr/hal-00877023/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-00877023/file/The_Neurogenic_Factor-accepted.pdf
DOI : 10.1371/journal.pone.0066487

Éditeur(s) : HAL CCSD
Résumé : International audience
L’agrotourisme, entre identité et développement : éclairages méditerranéens et insulaires
Corte, France

hal-01634312
https://hal.archives-ouvertes.fr/hal-01634312

Éditeur(s) : HAL CCSD Wiley/Blackwell
Résumé : 4 pages
International audience
This article documents the addition of 268 microsatellite marker loci to the Molecular Ecology Resources Database. Loci were developed for the following species: Alburnoides bipunctatus, Chamaerops humilis, Chlidonias hybrida, Cyperus papyrus, Fusarium graminearum, Loxigilla barbadensis, Macrobrachium rosenbergii, Odontesthes bonariensis, Pelteobagrus vachelli, Posidonia oceanica, Potamotrygon motoro, Rhamdia quelen, Sarotherodon melanotheron heudelotii, Sibiraea angustata, Takifugu rubripes, Tarentola mauritanica, Trimmatostroma sp. and Wallago attu. These loci were cross-tested on the following species: Alburnoides fasciatus, Alburnoides kubanicus, Alburnoides maculatus, Alburnoides ohridanus, Alburnoides prespensis, Alburnoides rossicus, Alburnoides strymonicus, Alburnoides thessalicus, Alburnoides tzanevi, Carassius carassius, Fusarium asiaticum, Leucaspius delineatus, Loxigilla noctis dominica, Pelecus cultratus, Phoenix canariensis, Potamotrygon falkneri, Trachycarpus fortune and Vimba vimba.
ISSN: 1755-098X

hal-00823716
https://hal.archives-ouvertes.fr/hal-00823716
DOI : 10.1111/1755-0998.12095
PUBMED : 23521844

Éditeur(s) : Leipzig : Duncker und Humblot
Siècle(s) traité(s) : 19
Droits : Domaine public
Provenance : Université Toulouse 1 Capitole. Service Commun de la Documentation
Permalien : http://www.manioc.org/patrimon/TLS17022
TLS17022

Date de création : 1928-01-01

Éditeur(s) : Paris : E. Flammarion
Siècle(s) traité(s) : 15
Droits : Domaine public
Provenance : Ville de Pointe-à-Pitre. Réseau des bibliothèques
Permalien : http://www.manioc.org/patrimon/PAP11064
PAP11064

Éditeur(s) : HAL CCSD
Résumé : International audience
OBJECTIVE: Contemporary pesticides, such as triazines or organophosphates, possess immunotoxic properties. We aimed to determine whether prenatal environmental exposure to these current-use pesticides was associated with otitis media (OM) during the first 2 years of life among children from the PELAGIE mother-child cohort. METHODS: The PELAGIE cohort enrolled 3421 women at the beginning of pregnancy in Brittany (France). At the 2-year follow-up, 1505 families completed a self-administered questionnaire, including the domestic use of pesticides and consumption of organic diet during pregnancy and occurrences of OM in the child. Two health outcomes were considered: at least one OM and recurrent OM (at least three). Multivariate logistic regression models that adjusted for known risk factors of OM were performed. Metabolites of triazine herbicides and organophosphate insecticides measured in urine collected before the 19th week of gestation (248 mothers) were considered in a subgroup analysis. Multiple imputation was used to handle missing values for the covariates. RESULTS: Children whose mothers reported an organic diet during pregnancy had a reduced risk of OM (at least one episode, p trend=0.01). No association was found between any outcome and residential proximity to crops. The presence in maternal urine of dealkylated triazine metabolites (OR=2.12 (1.01 to 4.47)) was positively associated with recurrent OM. CONCLUSIONS: To the best of our knowledge, this is the first work to suggest a positive association between prenatal exposure to current-use pesticides and the occurrence of parent-reported OM in young children
Occupational and Environmental Medicine

hal-01201944
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01201944
DOI : 10.1136/oemed-2015-103039
PUBMED : 26347056

Éditeur(s) : HAL CCSD BMJ Publishing Group
Résumé : International audience
OBJECTIVES: The time from the prenatal period through early childhood is an important window of vulnerability for the developing immune and respiratory systems, both sensitive to environmental chemicals such as solvents. This study sought to examine the effects of solvent exposure during the prenatal and postnatal periods on wheezing, eczema and food allergies in early childhood. METHODS: This study, based on the PELAGIE cohort, included 1505 mother-child pairs with measurements of prenatal and postnatal solvent exposures and data on wheezing, eczema or food allergies. The maternal occupation reported at inclusion, in early pregnancy allowed us to define prenatal occupational solvent exposure (by three specific job-exposure matrices). Data on prenatal and postnatal domestic solvent exposure, that is exposure to products that contain solvents, were obtained from self-administered questionnaires, once at inclusion and again when the child was 2 years old. Outcome data was collected at the 2-year follow-up. Associations between exposures and outcomes were estimated by logistic regression models, after adjustment for potential confounders. RESULTS: No association was observed between prenatal exposure to solvents and the outcomes studied. Postnatal exposure was associated with an increased risk of wheezing (OR=1.80 (95% CI 1.25 to 2.59)) which persisted after adjustment for prenatal exposure. No significant association was observed with eczema or food allergies. CONCLUSIONS: Postnatal exposure to solvent-containing products in the home may increase the risk of wheezing in early childhood. Follow-up studies are needed to determine if the health effects observed at age 2 persist at later ages.
ISSN: 1351-0711

hal-01063913
https://hal.archives-ouvertes.fr/hal-01063913
DOI : 10.1136/oemed-2013-102036
PUBMED : 24996679

Éditeur(s) : Paris : Libraire de Ch. Delagrave
Extrait de : Bulletin de la société de géographie
Résumé : Contient l'article : Notices géologiques sur la haute Guyanne française, d'après les explorations du docteur Crevaux. Articles manquants.
Siècle(s) traité(s) : 19
Provenance : Archives départementales de Guadeloupe
Permalien : http://www.manioc.org/patrimon/ADG18105
ADG18105

Éditeur(s) : HAL CCSD
Résumé : International audience
Island Tourism Sustainable Perspectives
Schoelcher, Martinique

hal-01641005
https://hal.univ-antilles.fr/hal-01641005

Éditeur(s) : HAL CCSD Wiley-Blackwell
Résumé : International audience
UNLABELLED: Interleukin (IL)-33, a member of the IL-1 cytokine family, positively correlates with acute hepatitis and chronic liver failure in mice and humans. IL-33 is expressed in hepatocytes and is regulated by natural killer T (NKT) cells during concanavalin A (ConA)-induced acute liver injury. Here, we investigated the molecular mechanisms underlying the expression of IL-33 during acute hepatitis. The expression of IL-33 and its regulation by death receptor pathways was investigated after the induction of ConA-acute hepatitis in wildtype (WT), perforin(-/-) , tumor necrosis factor related apoptosis inducing ligand (TRAIL)(-/-) , and NKT cell-deficient (CD1d(-/-) ) mice. In addition, we used a model of acute liver injury by administering Jo2/Fas-antibody or D-galactosamine-tumor necrosis factor alpha (TNFα) in WT mice. Finally, the effect of TRAIL on IL-33 expression was assessed in primary cultured murine hepatocytes. We show that IL-33 expression in hepatocytes is partially controlled by perforin during acute liver injury, but not by TNFα or Fas ligand (FasL). Interestingly, the expression of IL-33 in hepatocytes is blocked during ConA-acute hepatitis in TRAIL-deficient mice compared to WT mice. In contrast, administration of recombinant murine TRAIL associated with ConA-priming in CD1d-deficient mice or in vitro stimulation of murine hepatocytes by TRAIL but not by TNFα or Jo2 induced IL-33 expression in hepatocytes. The IL-33-deficient mice exhibited more severe ConA liver injury than WT controls, suggesting a protective effect of IL-33 in ConA-hepatitis. CONCLUSION: The expression of IL-33 during acute hepatitis is dependent on TRAIL, but not on FasL or TNFα.
ISSN: 0270-9139

hal-00874194
https://hal.archives-ouvertes.fr/hal-00874194
PUBMED : 22961755
DOI : 10.1002/hep.25893

Éditeur(s) : HAL CCSD
Résumé : International audience
In vitro evaluation of P-glycoprotein (P-gp) inhibitory potential is now a regulatory issue during drug development, in order to predict clinical inhibition of P-gp and subsequent drug-drug interactions. Assays for this purpose, commonly based on P-gp-expressing cell lines and digoxin as a reference P-gp substrate probe, unfortunately exhibit high variability, raising thus the question of developing alternative or complementary tests for measuring inhibition of P-gp activity. In this context, the present study was designed to investigate the use of the fluorescent dye rhodamine 123 as a reference P-gp substrate probe for characterizing P-gp inhibitory potential of 16 structurally-unrelated drugs known to interact with P-gp. 14/16 of these P-gp inhibitors were found to increase rhodamine 123 accumulation in P-gp-overexpressing MCF7R cells, thus allowing the determination of their P-gp inhibitory potential, i.e., their half maximal inhibitor concentration (IC50) value towards P-gp-mediated transport of the dye. These IC50 values were in the range of variability of previously reported IC50 for P-gp and can be used for the prediction of clinical P-gp inhibition according to Food and Drug Administration (FDA) criteria, with notable sensitivity (80%). Therefore, the data demonstrated the feasibility of the use of rhodamine 123 for evaluating the P-gp inhibitory potential of drugs
Pharmaceutics

hal-01305488
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01305488
DOI : 10.3390/pharmaceutics8020012
PUBMED : 27077878

Éditeur(s) : HAL CCSD Université des Antilles
Résumé : International audience
At the end of this year 2013, the Etudes Caribéennes Review reached its tenth birthday. This editorial proposes to trace the main stages of the construction of this academic journal and outlines its editorial policy. The Etudes Caribéennes Review is a space for sharing and meeting, from the Caribbean to Latino-Caribbean America, from insularity worlds to the "Tout-Monde" through a multidisciplinary approach while providing a privileged place to the land-use planning as a discipline carrefour. The making of the territory, its resources and their uses, interactions between actors and power, rethinking the “common”... All dimensions that gather our reflections.
Au terme de cette année 2013, la Revue Etudes Caribéennes atteint son dixième anniversaire. Cet éditorial propose de retracer les grandes étapes de la construction de cette revue universitaire et présente les grandes lignes de sa politique éditoriale. La Revue Etudes Caribéennes constitue un espace de partage et de rencontre, de la Caraïbe à l’Amérique latino-caribéenne, des mondes insulaires au « Tout-Monde », à travers une approche multidisciplinaire tout en accordant une place privilégiée à l’aménagement du territoire en tant que discipline carrefour. La fabrication du territoire, les ressources et leurs usages, les interactions entre les acteurs et les rapports au pouvoir, repenser le « commun »… Autant de dimensions qui fédèrent nos réflexions.
ISSN: 1779-0980

Droits : http://creativecommons.org/licenses/by-nc/
hal-01368443
https://hal.univ-antilles.fr/hal-01368443
https://hal.univ-antilles.fr/hal-01368443/document
https://hal.univ-antilles.fr/hal-01368443/file/revue-etudes-caribeennes-dix-ans-deja-dix-ans-enfin.pdf

Éditeur(s) : HAL CCSD Université des Antilles
Résumé : International audience
In this study, we propose to analyze the limits of mass tourism in the French Antilles, specifically the decline of tourism, economic limits, and ecological degradation). The recognition of these limits is overdue, and signals a need to define another model for tourism development.The popular coastal sector in the south of Martinique has been subject new regulations to protect marine resources. These regulations require the development of new practices and a greater level of awareness for tourists, for example, around coral reefs and mangroves. Ecotourism programs aim to demonstrate to visitors the forests rich natural resources and biodiversity in general. It also features the inclusion of small rural businesses that benefit from additional sources of revenue as a result of ecotourism.The situation in the French Antilles is complex: Urbanization is fraught with serious consequences for the coastline. Tourism products currently being marketed on the island are not competitive (particularly against the political dynamics of the neighbouring island of Dominica). Ecotourism and sustainable tourism are just beginning to develop in such destinations, where tourism has been declining in the last ten years. The situation of the French Antilles is paradoxical in a region that generally has a very favourable tourism. Assessing these limits through the scope of ecotourism helps to highlight the causes of these difficulties and to adapting to new tourism practices.
En el contexto de este estudio, nos proponemos analizar los límites del turismo de masas en las Antillas Francesas (depreciación del turismo, las limitaciones económicas, ecológicas y las molestias). Este reconocimiento de esos límites está en el origen de la conciencia tardía de la necesidad de definir otro modelo de desarrollo turístico.En el sector costero de la más popular, como en el sur de Martinica, se pone en la normativa nuevo lugar para proteger los recursos marinos. Esto requiere el desarrollo de nuevas prácticas y la sensibilización de los turistas, por ejemplo, alrededor de los arrecifes de coral y los manglares.Programas en torno al ecoturismo también tienen como objetivo dar al visitante la riqueza de los recursos forestales y la biodiversidad en general. También incluye las pequeñas empresas rurales que reciben los nuevos ingresos a través del turismo.Pero la situación es compleja en las Antillas francesas: la urbanización está llena de importantes consecuencias para la costa. Productos turísticos que se comercializan actualmente no son competitivos (en particular, contra la dinámica política de la cercana isla de Dominica). Ecoturismo y desarrollo sostenible están empezando a desarrollar en este destino turístico, donde el turismo está en problemas en los últimos diez años.Esta situación es bastante paradójico en un turismo regional muy favorable. Sin lugar a dudas, pensando en el ecoturismo contribuye a identificar los destinos de estos retrasos y dificultades para adaptarse a nuevas prácticas de turismo.
Dans le cadre de cette étude, l’accent est mis sur les limites du tourisme de masse dans les Antilles françaises (dépréciation du tourisme, les contraintes économiques et les nuisances écologiques). La reconnaissance de ces limites est à l'origine de la prise de conscience tardive de la nécessité de définir un autre modèle de développement touristique.Dans le sud de la Martinique, le secteur le plus populaire du littoral, de nouvelles règlementations sont mises en place pour protéger les ressources marines. Cela nécessite le développement de nouvelles pratiques et de sensibilisation des touristes notamment autour des récifs coralliens et les mangroves. Les programmes autour de l'écotourisme visent également à montrer aux visiteurs la richesse des ressources forestières et de la biodiversité en général. Il comprend également les petites entreprises rurales qui reçoivent de nouveaux revenus grâce au tourisme.La situation est complexe dans les Antilles françaises: l'urbanisation est lourde de conséquences importantes sur la côte. Les produits touristiques commercialisés actuellement ne sont pas compétitifs (notamment contre la dynamique politique de l'île voisine de la Dominique). L'écotourisme et le tourisme durable commencent tout juste à se développer dans ces destinations où le tourisme classique est en difficulté depuis une dizaine d’années ; situation assez paradoxale au regard du dynamisme de ce secteur d’activité dans la région.
ISSN: 1779-0980

hal-01624756
https://hal.archives-ouvertes.fr/hal-01624756
DOI : 10.4000/etudescaribeennes.5262