Éditeur(s) : HAL CCSD Impact journals
Résumé : International audience
Interleukin (IL)-33 has been recently reported to be strongly pro-fibrogenic in various models of liver disease. Our aim was to study the role of endogenous IL-33 in a diet-induced model of steatohepatitis. IL-33 deficient mice and wild type (WT) littermates received a high-fat diet (HFD), or a standard diet for 12 weeks. The HFD-induced steatohepatitis was associated with an upregulation of IL-33 transcripts and protein. An insulin tolerance test revealed lower systemic insulin sensitivity in IL33-/-HFD mice than in WT-HFD mice. Nevertheless, IL-33 deficiency did not affect the severity of liver inflammation by histological and transcriptomic analyses, nor the quantity of liver fibrosis. Livers from HFD mice had more myeloid populations, markedly fewer NKT cells and higher proportion of ST2+ Treg cells and ST2+ type 2 innate lymphoid cells (ILC2), all unaffected by IL-33 deficiency. In conclusion, deficiency of endogenous IL-33 does not affect the evolution of experimental diet-induced steatohepatitis towards liver fibrosis.
ISSN: 1949-2553

hal-01578584
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01578584
DOI : 10.18632/oncotarget.18335
PUBMED : 28611297

Éditeur(s) : HAL CCSD Cambridge University Press (CUP)
Résumé : We present detailed biostratigraphy based on conodonts and palaeoenvironmental trends deduced from microfacies and conodont abundance through the Famennian (Late Devonian) at Col des Tribes (Montagne Noire, France). The succession is characterized by micritic limestones deposited in settings oscillating between mid to outer ramp. Facies contain poor fauna, widely dominated by nektonic organisms. This section is complete and one of the most conodont-rich for the Famennian of the north Gondwana-related area. The Upper Kellwasser event (Frasnian–Famennian boundary) and the Hangenberg (Devonian–Carboniferous boundary) have been lithologically identified. They are characterized by decimetre-thick black dysoxic to anoxic argillaceous sediments. The Condroz and annulata events, although not materialized by lithological changes, have been positioned due to the precise stratigraphy. The first event occurred during the deposition of condensed ferruginous facies (griotte limestones) and the second event during the deposition of micrites barren of benthic fauna. The combination of information from both facies and conodont biofacies changes allows a general sea-level curve through the entire Famennian for north Gondwana to be proposed for the first time. At Col des Tribes, the general trend is a slight deepening upwards from triangularis to trachytera zones, then a pronounced shallowing-upwards trend from upper trachytera to praesulcata zones. This curve correlates with the well-known reference curve from Euramerica concerning the late Famennian (trachytera to praesulcata Zones). There are some discrepancies in minor cycles which can be explained by tectonical phenomena at the onset of the edification of the Variscan belt in Europe.
ISSN: 0016-7568

hal-01115222
https://hal.archives-ouvertes.fr/hal-01115222
DOI : 10.1017/S0016756813000927

Éditeur(s) : HAL CCSD
Résumé : International audience
International Journal of GreenhouseGas Control

hal-01314405
https://hal-brgm.archives-ouvertes.fr/hal-01314405

Éditeur(s) : HAL CCSD Borntraeger Science Publishers
Résumé : This study characterizes the stratigraphical context as well as the palaeoenvironmental and sealevel trends during the Late Frasnian and Famennian in the Buschteich section (Thuringia, Germany). An integrated approach combines conodont biostratigraphy, chemostratigraphy based on carbon and oxygen isotopes, conodont biofacies analyses and investigations of the morphotypes of foraminifera that occur in the section was applied. Conodonts provided a fine-scale biostratigraphical framework. All the Famennian conodont biozones were identified, with the exception of the three lowest. The Frasnian – Famennian transition was further identified by a positive carbon isotope excursion. This continuous Famennian record is developed in a condensed limestone succession. The reddish Griotte facies, typical of strata of this period, were not documented. Black shales were not developed except for an interval of dark colored mud rocks corresponding to the Hangenberg event at the top of the section. The carbonate succession of Buschteich was deposited in an outer ramp environment, pelagic organisms are the dominant fauna. This is corroborated by the overall dominance of the deep-water conodont genus Palmatolepis. Microfacies, conodont biofacies and foramini fera indicated a deepening trend from the Lower crepida to the Lower rhomboidea Zone, followed by a shallowing trend from the Upper rhomboidea to the praesulcata Zone. This sequence overall matches the sea level reference curve for Euramerica. The timing of maximum water depth at Buschteich, as well as the general sea-level reference record, differs from the Col des Tribes (Montagne Noire, France). Differential uplift or overprinting of the long-term eustatic changes may be the cause of the discrepancy in the local sea-level records.
ISSN: 0078-0421

hal-01623111
https://hal.archives-ouvertes.fr/hal-01623111
DOI : 10.1127/nos/2016/0318

Éditeur(s) : HAL CCSD Cambridge University Press (CUP)
Résumé : International audience
The Ben Zireg anticline NW of Bechar yields the currently most-important Frasnian succession on the northern margin of the Algerian Sahara. It represents 26.5 m of calcilutites which are attributed to the middle–late Frasnian. As the early Frasnian is not represented, the succession rests conformably on undifferentiated, probably late Givetian, substrate. Fine-scaled conodont biostratigraphy reveals a continuous sequence of Montagne Noire Zones 5–13, superseded by the earliest Famennian Lower triangularis Zone. The deposits are organized into 15 sedimentary cycles that are initially condensed and become dilated upwards. Conodont biofacies indicate an overall deepening towards the top of the section with an episode of slight shallowing at the MN11/12 transition marked by an increase of ancyrodellids, which is also seen in the Marhouma section of the Ougarta region (SW Algeria). Homogeneous calcareous microfacies with only a few shaly intercalations determine a predominantly oxygenated depositional environment on an outer platform, submarine rise or ramp setting. This is also indicated by relatively low sedimentation rates which are similar in selected sections from the Tafilalt platform, and contrast with those from the Marhouma trough and the Maider basin. Unlike other Frasnian successions south of the Atlas Fault, but similar to the Moroccan Meseta, the Upper Kellwasser horizon is clearly discriminated at Ben Zireg by an outstanding occurrence of black shales on top of the oxygenated latest Frasnian deposits.
ISSN: 0016-7568

hal-01217151
https://hal.archives-ouvertes.fr/hal-01217151
DOI : 10.1017/S0016756814000715

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Fromthe Proterozoic to the Quaternary, the evolution of the Earthwas characterised by recurrent periods of glaciation.However, the margins of many ancient ice-sheets are poorly defined on palaeogeographic reconstructions.The extent and outlines of ancient ice sheets can be better understood through careful documentation ofsediments deposited at the ice-sheet margin. An outstanding example is provided herein based on an end-Ordovician archive in Libya (Tihemboka area, Murzuq Basin). The four sets of structures include: i) subglacialglaciotectonic structures and soft sediment deformations from flowing glacier ice, such as intraformational glacialstriae, intraformational deformation (shear planes, sheath folds), normal microfaults, and large-scaleglaciotectonic folds-and-thrusts; (ii) structures resulting from overpressured subglacial (meltwater) flowssuch as clastic dykes and tunnel valleys; (iii) proglacial depositional structures and facies related to highmagnitudemeltwater floods such as sandstone intraclasts, large-scale bedforms resulting from supercriticalflows, climbing-dune cross-stratification and kettle holes; and (iv) deformation structures resulting from freefloating and nonglacier ice such as ice-keel scours and ice-crystal marks. Such a set of structures points to anice-marginal (essentially continental) depositional setting, and provides an excellent suite of criteria to identifymargins of ancient ice sheets in the stratigraphic record. At a regional scale, a reconstruction through time andspace of the related depositional wedge is proposed. This corresponded to a seismic-scale (N120 m in thickness,40 km in length) ice-marginal wedge in front of an essentially warm-based ice-sheet inducing concomitantlarge-scale glaciotectonic deformation, glacial basin and tunnel valley downcuttings. The related ice-front wasassociated with high-energy meltwater flows feeding a network of deeply incised proglacial channels downstreamand, beyond them, a fluvioglacial deltaic system. Shallow ice-marginal permafrost most likely affectedthe depositional wedge. At a larger scale, the Tihemboka ice-marginal wedge is interpreted as related to a stillstandperiod over the Gondwana platform, developed over an estimated interval of a few thousands of years.Based on these data, the conditions that arose in a particularly favourable context for the development, the preservationand the identification of ice-marginal wedges in the geological record are reviewed. Significantmeltwater-derived sediment deposition and aggradation in an accommodation space resulting either frompreglacial inheritance, glacial downcuttings and/or glacio-isostatic lithospheric flexure, or active tectonic subsidence(>1 Myr) are required for their formation and subsequent preservation.
ISSN: 0012-8252

insu-01184739
https://hal-insu.archives-ouvertes.fr/insu-01184739
DOI : 10.1016/j.earscirev.2015.06.006

Éditeur(s) : HAL CCSD Wiley-Blackwell
Résumé : International audience
UNLABELLED: Interleukin (IL)-33, a member of the IL-1 cytokine family, positively correlates with acute hepatitis and chronic liver failure in mice and humans. IL-33 is expressed in hepatocytes and is regulated by natural killer T (NKT) cells during concanavalin A (ConA)-induced acute liver injury. Here, we investigated the molecular mechanisms underlying the expression of IL-33 during acute hepatitis. The expression of IL-33 and its regulation by death receptor pathways was investigated after the induction of ConA-acute hepatitis in wildtype (WT), perforin(-/-) , tumor necrosis factor related apoptosis inducing ligand (TRAIL)(-/-) , and NKT cell-deficient (CD1d(-/-) ) mice. In addition, we used a model of acute liver injury by administering Jo2/Fas-antibody or D-galactosamine-tumor necrosis factor alpha (TNFα) in WT mice. Finally, the effect of TRAIL on IL-33 expression was assessed in primary cultured murine hepatocytes. We show that IL-33 expression in hepatocytes is partially controlled by perforin during acute liver injury, but not by TNFα or Fas ligand (FasL). Interestingly, the expression of IL-33 in hepatocytes is blocked during ConA-acute hepatitis in TRAIL-deficient mice compared to WT mice. In contrast, administration of recombinant murine TRAIL associated with ConA-priming in CD1d-deficient mice or in vitro stimulation of murine hepatocytes by TRAIL but not by TNFα or Jo2 induced IL-33 expression in hepatocytes. The IL-33-deficient mice exhibited more severe ConA liver injury than WT controls, suggesting a protective effect of IL-33 in ConA-hepatitis. CONCLUSION: The expression of IL-33 during acute hepatitis is dependent on TRAIL, but not on FasL or TNFα.
ISSN: 0270-9139

hal-00874194
https://hal.archives-ouvertes.fr/hal-00874194
PUBMED : 22961755
DOI : 10.1002/hep.25893

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
Pituitary adenomas are currently classified by histological, immunocytochemical and numerous ultrastructural characteristics lacking unequivocal prognostic correlations. We investigated the prognostic value of a new clinicopathological classification with grades based on invasion and proliferation. This retrospective multicentric case-control study comprised 410 patients who had surgery for a pituitary tumour with long-term follow-up. Using pituitary magnetic resonance imaging for diagnosis of cavernous or sphenoid sinus invasion, immunocytochemistry, markers of the cell cycle (Ki-67, mitoses) and p53, tumours were classified according to size (micro, macro and giant), type (PRL, GH, FSH/LH, ACTH and TSH) and grade (grade 1a: non-invasive, 1b: non-invasive and proliferative, 2a: invasive, 2b: invasive and proliferative, and 3: metastatic). The association between patient status at 8-year follow-up and age, sex, and classification was evaluated by two multivariate analyses assessing disease- or recurrence/progression-free status. At 8 years after surgery, 195 patients were disease-free (controls) and 215 patients were not (cases). In 125 of the cases the tumours had recurred or progressed. Analyses of disease-free and recurrence/progression-free status revealed the significant prognostic value (p < 0.001; p < 0.05) of age, tumour type, and grade across all tumour types and for each tumour type. Invasive and proliferative tumours (grade 2b) had a poor prognosis with an increased probability of tumour persistence or progression of 25- or 12-fold, respectively, as compared to non-invasive tumours (grade 1a). This new, easy to use clinicopathological classification of pituitary endocrine tumours has demonstrated its prognostic worth by strongly predicting the probability of post-operative complete remission or tumour progression and so could help clinicians choose the best post-operative therapy.
ISSN: 0001-6322

hal-00875723
https://hal.archives-ouvertes.fr/hal-00875723
DOI : 10.1007/s00401-013-1084-y
PUBMED : 23400299

Éditeur(s) : HAL CCSD Wiley-VCH Verlag
Résumé : International audience
Deciphering the assembly history of the Milky Way is a formidable task, which becomes possible only if one can produce high-resolution chrono-chemo-kinematical maps of the Galaxy. Data from large-scale astrometric and spectroscopic surveys will soon provide us with a well-defined view of the current chemo-kinematical structure of the Milky Way, but will only enable a blurred view on the temporal sequence that led to the present-day Galaxy. As demonstrated by the (ongoing) exploitation of data from the pioneering photometric missions CoRoT, Kepler, and K2, asteroseismology provides the way forward: solar-like oscillating giants are excellent evolutionary clocks thanks to the availability of seismic constraints on their mass and to the tight age-initial-mass relation they adhere to. In this paper we identify five key outstanding questions relating to the formation and evolution of the Milky Way that will need precise and accurate ages for large samples of stars to be addressed, and we identify the requirements in terms of number of targets and the precision on the stellar properties that are needed to tackle such questions. By quantifying the asteroseismic yields expected from PLATO for red-giant stars, we demonstrate that these requirements are within the capabilities of the current instrument design, provided that observations are sufficiently long to identify the evolutionary state and allow robust and precise determination of acoustic-mode frequencies. This will allow us to harvest data of sufficient quality to reach a 10% precision in age. This is a fundamental pre-requisite to then reach the more ambitious goal of a similar level of accuracy, which will only be possible if we have to hand a careful appraisal of systematic uncertainties on age deriving from our limited understanding of stellar physics, a goal which conveniently falls within the main aims of PLATO's core science.
ISSN: 0004-6337

hal-01541393
https://hal.archives-ouvertes.fr/hal-01541393
ARXIV : 1706.3778
BIBCODE : 2017AN....338..644M
DOI : 10.1002/asna.201713385

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Cytokine
Genève, Switzerland

hal-01118456
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118456
DOI : 10.1016/j.cyto.2012.06.182

Éditeur(s) : HAL CCSD
Résumé : International audience
A CO 2 migration field laboratory for testing of monitoring methods has been established in the glaciofluvial-glaciomarine Holocene deposits of the Svelvik ridge, near Oslo. A shallow CO 2 injection experiment was conducted in September 2011 in which approximately 1700 kg of CO 2 was injected at 18 m depth below surface. The objectives of this experiment were to (i) detect and, where possible, quantify migrated CO 2 concentrations, (ii) evaluate the sensitivity of the monitoring tools and (iii) study the impact of the vadose zone on measurements. This paper describes the injection, discusses the joint interpretation of the results and suggests some recommendations for further work.
The 7th Trondheim CCS Conference
Trondheim, Norway

hal-01314396
https://hal-brgm.archives-ouvertes.fr/hal-01314396
https://hal-brgm.archives-ouvertes.fr/hal-01314396/document
https://hal-brgm.archives-ouvertes.fr/hal-01314396/file/1-s2.0-S1876610214008704-main.pdf
DOI : 10.1016/j.egypro.2014.07.008