Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The aim of this study was to establish a new QuEChERS (quick, easy, cheap, effective, rugged and safe) method coupled to gas chromatography-mass spectrometry (GC-MS) detection for the evaluation of the pesticide biodistribution in specific maternal and fetal tissues. This method was validated for the quantification of pesticides such as chlorotriazines (atrazine, simazine and propazine), their chlorinated metabolites (DIA, DEA and DACT). This new QuEChERS method was developed to facilitate extraction from small tissues such as fetal tissues (mean value: 200mg). The limits of detection, quantification, recovery, precision and accuracy were evaluated for different tissues (liver and brain) and blood. LOD and LOQ ranged between 0.34 and 3.27 ng/g and 1.04 to 9.91 ng/g, respectively. Recovery exceeded 80% for all pesticides, except DACT, with an associated RSD<15%. Precision and accuracy satisfied the criteria usually applied in the validation of bioanalytical methods. The results obtained indicate that this technique is suitable for use in studies of the biodistribution of pesticides in fetal tissues and can be used to evaluate the risk of exposure to pesticides during gestation.
ISSN: 0731-7085

hal-01122837
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01122837
PUBMED : 25497890
DOI : 10.1016/j.jpba.2014.10.035

Éditeur(s) : HAL CCSD Lippincott, Williams & Wilkins
Résumé : International audience
Among 103 patients with multidrug-resistant HIV who initiated raltegravir, etravirine, and darunavir/ritonavir-containing regimen in the ANRS 139 TRIO trial, 100 participated in extended follow-up and continued study treatment until week 96. Among them, 87 (87%) received an optimized background therapy including either nucleoside reverse transcriptase inhibitors or enfuvirtide, they were 78 (78%) at week 96. At week 96, 88% achieved durable virologic response (<50 copies/mL). CD4 response was maintained (median change of +150 cells/mm(3)). No major toxicity was reported. This triple drug combination showed sustained efficacy and thus should be strongly considered for patients with multiclass-resistant virus.
ISSN: 1525-4135

hal-00875207
https://hal.archives-ouvertes.fr/hal-00875207
DOI : 10.1097/QAI.0b013e31824bb720
PUBMED : 22293546

Éditeur(s) : HAL CCSD Springer International Publishing
Résumé : The intensive farming practices that have been developed over the past 60 years are based mainly on the use of chemical inputs such as fertilisers and pesticides, mechanical tillage and monoculture. The limitations of these methods are now clear: long-term degradation of soil fertility, impacts on the environment and human health, high consumption of fossil fuels, low efficiency of inputs and threats to food security in a context of climate change. Would farming practices that rely on the activation of ecological processes be an alternative to achieve a balance between high productivity and environmental preservation? While many studies suggest a positive relationship between soil biodiversity and ecosystem services, there is considerable debate on the form such agricultural systems should take. This study reviewed the state of current knowledge and identified aspects requiring further research to achieve the aim of sustainable intensification of agriculture. The following major points emerged: 1) Most studies focused on the evaluation of individual practices. However, changes in farmers’ cropping practices to take advantage of soil biodiversity services would need to manage not only the interactions between various practices but also the trade-off between the technical and socio economic constraints of cropping systems. Advances in agricultural system design approaches may help to ensure appropriate trade-offs. 2) More attention should be given to drawing on knowledge from different sources: laboratory studies focusing on the ecological functions of soil biodiversity, experimental surveys on farmers’ fields to rank the farming practices and processes to be included in site-specific models, and on- station experiments to test hypotheses and acquire additional reference material. 3) Whereas advances in technical and scientific knowledge provide an increasing number of relevant indicators for characterizing biodiversity and ecological functions, studies are rarely targeted at the development of indicators that are accessible to farmers or their technical advisors. The lack of indicators accessible to grassroots players for evaluating the impacts of their decisions on soil biodiversity remains a serious obstacle to the development of innovative agro-ecological systems.
Sustainable Agriculture Reviews 14

ISBN : 978-3-319-06015-6
hal-01268743
https://hal.archives-ouvertes.fr/hal-01268743
DOI : 10.1007/978-3-319-06016-3_5
PRODINRA : 270786

Éditeur(s) : Université des Antilles Études caribéennes
Résumé : El presente artículo tiene como objetivo, valorar la conducta ética del profesional en turismo como elemento incidente en el servicio innovador y sostenible de la actividad turística. Es un análisis crítico ya que en él se da una relación constructiva de la teoría y la práctica, de lo que es y el deber ser de las ejecuciones de los profesionales del turismo. Para su abordaje se procedió a un estudio documental, basado en la revisión bibliográfica de material actualizado sobre el tema en cuestión, llegando a la conclusión de que toda innovación turística, desde la identificación y conversión de recurso turístico hasta su puesta en valor como producto turístico, requiere de un sistema de información turística, de una tecnología. Además el turismo sostenible es una estrategia que promueve el desarrollo de comunidades con riquezas paisajísticas, culturales, ambientales, etc. La práctica ética del profesional en turismo es determinante en la calidad del servicio hotelero innovador y en esa medida se contribuye a que éste sea sostenible en el tiempo.
This article aims, assess the ethical conduct of professional tourism as an element incident innovative and sustainable tourism service. It is a critical analysis since it constructive relationship of theory and practice, of what is and what ought to be the executions of tourism professionals is given. For your approach proceeded to a desk study, based on a literature review of current on the subject matter material concluding that all tourism innovation, from identification and conversion of resource to its value as a tourism product requires a tourist information system, a technology. Furthermore sustainable tourism is a strategy that promotes the development of communities Scenic, cultural, environmental wealth, etc. The practice of professional ethics in tourism is crucial to the quality of service and innovative Hotelier this measure helps to make it sustainable over time.

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.9452
http://journals.openedition.org/etudescaribeennes/9452

Éditeur(s) : Littoral 2004, Aberdeen, Scotland, UK, September 2004
Résumé : NAMIBIE (a french acronym for Integrated Multimedia Navigator Within Coastal Environment Data Bases) is a specific tool which first concept has been established by Ifremer and has been developped by an association between research in the field of coastal environment, innovation in the field of new information and communication technologies and services in the field of coastal integrated management and impact studies. The objectives of this tool are to facilitate research, direct access and display of relevant multimedia coastal integrated data and information according to an interactive, widely opened and playfull interface. The principles are based upon the fact that sustainable decision making needs an optimized unterstanding of coastal processes and better consultation between actors. In this purpose the development of the tool has considered that the end-user should and could be free to look after the data and the information he needs for a particular site or environment of interest and for a specific ICZM question according to easy navigation interfaces. That is why NAMIBIE concept is based upon : - a coherent 3D representation of the coasts (i.e. from catchement areas to continental shelf and deep sea), which considers a coherent DEM from land to sea and textural representation of the environment using satellite imagery textural displays, - a 3D navigator which allows the user to fly or dive over and within the coastal environment of interest, - a multimedia database (text, graphs, image, maps, geographic objects, modelling results...) specific to the territory of interest, - an interactive interface which helps in finding relevant information associated to specific questions. The technologies used include VRML data format, integration of standard GIS format (shp, grid, img) within the navigator, integration and display of modelling data. The production chain is realized in C++ and Java scripts allow dialogue between web pages and 3D windows. Applications are presented on the coasts of Languedoc Roussillon region (French Mediterranean border) in the framework of ICZM problematics

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/00089/20055/17696.pdf
http://archimer.ifremer.fr/doc/00089/20055/

Éditeur(s) : HAL CCSD
Résumé : The modernization of agriculture is under scrutiny. It is currently debated within the growing concept and practice of agroecology that applies ecological fundaments to the design and the management of sustainable agroecosystems. In matter of ecologization of agriculture, agroecological transition may be considered as a privileged pathway. It relies on two main forms: the weak (that intends to reduce the use of chemicals by alternative practices such as their substitution by biological inputs) versus strong modernization of agriculture (based on the valorization of biodiversity providing ecosystemic services). In this article, through an analysis of the technological innovations used for the enhancement of mycorrhiza (symbiotic interactions between plants and soil microorganisms) as an illustration of the implementation of the agroecological transition in France, we wonder in what extent a strong modernization of agriculture is likely to occur.This paper shows how the conceptual framework of socio-technical regime is useful to analyze the dynamics of the agroecological transition. Our demonstration relies on an empirical material (survey of the main actors of the mycorrhiza supply chain) that permits to understand how is structured the dominant system and how it impedes the development of the alternative niche. We then give some prerequisites in terms of public action to define in what extent the niche can be supported and can compete the current system.
54. ERSA Congress "Regional development & globalization: Best practices"
Saint-Petersburg, Russia

hal-01606449
https://hal.archives-ouvertes.fr/hal-01606449
PRODINRA : 387723