Éditeur(s) : Université de Guyane
Extrait de : Séminaire préparatoire aux états généraux du multilinguisme dans les Outre-mer, le 27 mars 2021. Université de Guyane
Siècle(s) traité(s) : 21
Droits : Ce document est protégé par le droit d'auteur. Il ne peut en aucun cas être utilisé sans l'autorisation de l'auteur et des ayant droits
Permalien : http://www.manioc.org/fichiers/V21032
V21032

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
ISSN: 0003-4975

hal-01563338
http://hal.univ-brest.fr/hal-01563338
DOI : 10.1016/j.athoracsur.2016.03.093
PUBMED : 27262916

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Aims: The aims of this study were to compare short-and long-term outcomes for clinical T2N0 oesophageal cancer with analysis of (i) primary surgery (S) versus neoadjuvant therapy plus surgery (NS), (ii) squamous cell carcinoma and adenocarcinoma subsets; and (iii) neoadjuvant chemoradiotherapy versus neoadjuvant chemotherapy.Methods: Data were collected from 30 European centres from 2000 to 2010. Among 2944 included patients, 355 patients (12.1%) had cT2N0 disease; 285 (S) and 70 (NS), were compared in terms of short-and long-term outcomes. Propensity score matching analyses were used to compensate for differences in baseline characteristics.Results: No significant differences between the groups were shown in terms of in hospital morbidity and mortality. Nodal disease was observed in 50% of S-group at the time of surgery, with 20% pN2/N3. Utilisation of neoadjuvant therapy was associated with significant tumour downstaging as reflected by increases in pT0, pN0 and pTNM stage 0 disease, this effect was further enhanced with neoadjuvant chemoradiotherapy. After adjustment on propensity score and confounding factors, for all patients and subset analysis of squamous cell and adenocarcinoma, neoadjuvant therapy had no significant effect upon survival or recurrence (overall, loco-regional, distant or mixed) compared to surgery alone. There were no significant differences between neoadjuvant chemotherapy and chemoradiotherapy in short-or long-term outcomes.Conclusion: The results of this study suggest that a surgery alone treatment approach should be recommended as the primary treatment approach for cT2N0 oesophageal cancer despite 50% of patients having nodal disease at the time of surgery.
ISSN: 0959-8049

hal-01666517
https://hal.univ-lorraine.fr/hal-01666517
DOI : 10.1016/j.ejca.2015.11.024

Éditeur(s) : HAL CCSD
Résumé : International audience
Up-to-date estimates of the health outcomes of preterm children are needed for assessing perinatal care, informing parents, making decisions about care, and providing evidence for clinical guidelines. To determine survival and neonatal morbidity of infants born from 22 through 34 completed weeks' gestation in France in 2011 and compare these outcomes with a comparable cohort in 1997. The EPIPAGE-2 study is a national, prospective, population-based cohort study conducted in all maternity and neonatal units in France in 2011. A total of 2205 births (stillbirths and live births) and terminations of pregnancy at 22 through 26 weeks' gestation, 3257 at 27 through 31 weeks, and 1234 at 32 through 34 weeks were studied. Cohort data were collected from January 1 through December 31, 1997, and from March 28 through December 31, 2011. Analyses for 1997 were run for the entire year and then separately for April to December; the rates for survival and morbidities did not differ. Data are therefore presented for the whole year in 1997 and the 8-month and 6-month periods in 2011. Survival to discharge and survival without any of the following adverse outcomes: grade III or IV intraventricular hemorrhage, cystic periventricular leukomalacia, severe bronchopulmonary dysplasia, retinopathy of prematurity (stage 3 or higher), or necrotizing enterocolitis (stages 2-3). A total of 0.7% of infants born before 24 weeks' gestation survived to discharge: 31.2% of those born at 24 weeks, 59.1% at 25 weeks, and 75.3% at 26 weeks. Survival rates were 93.6% at 27 through 31 weeks and 98.9% at 32 through 34 weeks. Infants discharged home without severe neonatal morbidity represented 0% at 23 weeks, 11.6% at 24 weeks, 30.0% at 25 weeks, 47.5% at 26 weeks, 81.3% at 27 through 31 weeks, and 96.8% at 32 through 34 weeks. Compared with 1997, the proportion of infants surviving without severe morbidity in 2011 increased by 14.4% (P < .001) at 25 through 29 weeks and 6% (P < .001) at 30 through 31 weeks but did not change appreciably for those born at less than 25 weeks. The rates of antenatal corticosteroid use, induced preterm deliveries, cesarean deliveries, and surfactant use increased significantly in all gestational-age groups, except at 22 through 23 weeks. The substantial improvement in survival in France for newborns born at 25 through 31 weeks' gestation was accompanied by an important reduction in severe morbidity, but survival remained rare before 25 weeks. Although improvement in survival at extremely low gestational age may be possible, its effect on long-term outcomes requires further studies. The long-term results of the EPIPAGE-2 study will be informative in this regard.
ISSN: 2168-6211

hal-01258705
http://hal.univ-brest.fr/hal-01258705
PUBMED : 25621457
DOI : 10.1001/jamapediatrics.2014.3351

Éditeur(s) : HAL CCSD
Résumé : Les dossiers thématiques d'Agropolis, n° 11
Dans le contexte actuel de contraintes climatiques et socioéconomiques, les agricultures des zones sèches doivent évoluer afin de s’adapter et de répondre à un double défi : produire plus pour satisfaire les besoins alimentaires importants de populations en croissance, mais aussi produire mieux de façon viable et durable. Pour cela, les agricultures de ces zones doivent évoluer vers des modes de production à la fois plus productifs, économes en ressources naturelles et résistants aux aléas climatiques.Dans ce cadre, l’ingénierie écologique propose de nouvelles alternatives de gestion des systèmes agro-sylvo-pastoraux caractéristiques des régions arides et semi-arides d’Afrique subsaharienne. Ceci implique de maitriser la complexité des systèmes étudiés et de s’inspirer à la fois du fonctionnement des écosystèmes naturels de référence à la région agroécologique concernée — les savanes pour les zones sèches ouest-africaines — et des pratiques traditionnelles et savoir-faire locaux issus d’une longue adaptation face aux contraintes environnementales.À partir des expériences ouest-africaines notamment, différentes options pratiques sont exposées dans ce dossier. On pourra ainsi agir sur la biodiversité des organismes, que ce soit les plantes ou les microorganismes du sol par exemple, favoriser le recyclage des matières organiques et des éléments nutritifs pour les plantes qui sont associées, maitriser les cycles de l’eau et, enfin, agir sur l’organisation des paysages pour favoriser un meilleur contrôle des ravageurs de culture.Cependant, développer une telle approche demande une vision intégrée du fonctionnement et de l’évolution des systèmes agro-sylvo-pastoraux. Les questions sociales — le foncier, l’urbanisation et les migrations — et économiques — les marchés des denrées de première nécessité, la pauvreté, etc. — sont des déterminants essentiels qu’il convient de prendre en compte pour le développement durable des populations dans les zones sèches en Afrique subsaharienne.
https://hal.archives-ouvertes.fr/hal-01585038

hal-01585038
https://hal.archives-ouvertes.fr/hal-01585038

Éditeur(s) : HAL CCSD BioScientifica
Résumé : International audience
The general rules established from mammalian species for the regulation of spermatogenesis by gonadotropins may not be fully relevant in fish. Particularly, Fsh is as potent as Lh to stimulate steroidogenesis and the Fsh receptor is expressed in Leydig cells. In seasonal breeders, Fsh is likely the major gonadotropin involved in spermatogenesis onset and Lh is required to support spermatogenesis progression and gamete release. However, the genes that relay the action of Fsh and Lh have been poorly investigated in fish. The present study was aimed at identifying gonadotropin-dependent genes expressed in the testis during fish puberty. We cultured pubertal trout testicular explants for 96 h, with or without gonadotropin, and analyzed transcriptome variations using microarrays. Fsh and Lh had similar effects on a large group of genes while other genes were preferentially regulated by one or the other gonadotropin. We showed that most of the responsive genes were expressed in somatic cells and exhibited relevant patterns during the seasonal reproductive cycle. Some genes preferentially modulated by Lh could be involved in testicular cell fate (pvrl1 and bty) or sperm maturation (ehmt2 and racgap1) and will deserve further examination. Besides Fsh's effects on the steroidogenic pathway, our study demonstrates that Fsh coordinates relevant stimulatory and inhibitory paracrine factors known to regulate early germ cell proliferation and differentiation. Some of these genes belong to major regulatory pathways including the Igf pathway (igf1b/igf3 and igfbp6), the Tgfb pathway (amh, inha, inhba, and fstl3), the Wnt pathway (wisp1), and pleiotrophin (mdka).
ISSN: 0952-5041

inserm-00812401
http://www.hal.inserm.fr/inserm-00812401
DOI : 10.1530/JME-12-0197
PUBMED : 23045716

Éditeur(s) : HAL CCSD Springer Verlag/EDP Sciences
Résumé : International audience
Context: Woodcutting is a very old technology but scientific research is scarce on the subject. In the last 50 years much work on basic mechanisms as well as industrial processes has been done in France. Aims: The specific nature of wood introduces strong differences between wood and metal cutting processes. The paper focuses on French teams' contributions. Results: The basic aspects of the tool–material interaction for different basic modes in woodcutting are highlighted. In primary conversion such as sawing, veneer cutting or green wood chipping, huge progress comes from automation and the possibility of linking the process to log and product quality through new sensors. In secondary processing much has been done on the links between the cutting process, surface qualification and the properties of these surfaces for further processing, such as gluing or coating. Tool wear depends on the cutting process, timber quality, and species. Trade-offs are required in tool technology and coating technologies may improve tool life. Conclusion: A large amount of knowledge and innovation has come from 50 years of worldwide research effort, with France being particularly active in this period. The transfer of skills from metals cutting industry was often a key, but much is needed to move closer to both metal cutting sector and woodcutting skills among craftsmen.
ISSN: 1286-4560

hal-01135156
https://hal.archives-ouvertes.fr/hal-01135156
https://hal.archives-ouvertes.fr/hal-01135156/document
https://hal.archives-ouvertes.fr/hal-01135156/file/Wood_machining_focus_French_research_Thibaut_al_2015.pdf
DOI : 10.1007/s13595-015-0460-2

Éditeur(s) : HAL CCSD Landes Bioscience
Résumé : International audience
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
Autophagy

hal-00735751
https://hal.archives-ouvertes.fr/hal-00735751
PUBMED : 22966490

Éditeur(s) : HAL CCSD Société nationale de protection de la nature
Résumé : International audience
The island of Moorea in French Polynesia is representative of a relatively well preserved small tropical oceanic island but both its terrestrial and marine ecosystems are currently under strong anthropogenic pressures. The terrestrial ecosystems are facing an increasing urbanization, and the destruction and modification of their natural habitats by cultivation and forestry plantations, accidental or intentional fires, and particularly by the invasion of alien plant and animal species. Coastal areas and reef ecosystems are threatened by shoreline artificialization, sedimentation due to soil erosion, increasing uses of marine and lagoon resources and frequency of coral bleaching events. A significant erosion of terrestrial and marine biodiversity is observed on the island since the last decades. In the context of the Land Management Plan (PGA) and Marine Area Management Plan (PGEM) recently set up in the island by local authorities, scientific surveys and inventories were made in 2006 in order to assess the status of terrestrial biodiversity (vascular plants) and marine biodiversity (reef fishes) and compare areas with different anthropogenic pressures. Studies conducted on the flora and the vegetation at low and middle elevation along altitudinal transects show that the plant invasion process is related to climatic and topographic factors, and species autoecology. The marine study aims to compare the protected areas with control areas in order to test the effectiveness of protection measures and to propose a streamlined monitoring protocol. A methodological study in both terrestrial and marine ecosystems was conducted in order to propose biodiversity indicators which are crucial for decision making in conservation and sustainable development of island biodiversity. We used Geographic Information System (GIS) as a fast and intuitive tool for mapping indicators and their variability. This methodological approach developed on the island of Moorea could be used as a model for other tropical islands
Moorea est une petite île océanique tropicale de la Polynésie française relativement bien préservée, mais dont les écosystèmes terrestres et marins sont actuellement soumis à de fortes pressions anthropiques. Le milieu terrestre est confronté à une urbanisation croissante, à la destruction ou à la modification des habitats naturels pour l’extension des cultures ou des plantations forestières, aux incendies volontaires ou accidentels, et particulièrement à l’invasion d’espèces végétales et animales introduites. Les zones côtières et les récifs coralliens sont menacés par de multiples perturbations telles que l’artificialisation des lignes de rivage, l’apport de sédiments dus à l’érosion des sols, l’augmentation des usages des ressources marines et lagonaires et de la fréquence des phénomènes de blanchissement du corail. Une érosion sensible de la biodiversité terrestre et marine de l’île est observée depuis les dernières décennies. Dans le cadre du Plan Général d’Aménagement (PGA) et du Plan de Gestion de l’Espace Maritime (PGEM) mis en place par les autorités locales, des inventaires scientifiques ont été réalisés en 2006 dans le but d’évaluer l’état de la biodiversité terrestre (plantes vasculaires) et marine (poissons récifaux) et de comparer des zones soumises à différentes perturbations. Les études réalisées sur la flore et la végétation de basse et moyenne altitude le long de transects altitudinaux montrent des processus d’invasion végétale différents en relation avec les facteurs climatiques, topographiques et autoécologiques des espèces. Les études en milieu marin visent à comparer des aires protégées à des aires témoins afin de suivre l’efficacité des mesures de gestion. La réflexion méthodologique menée parallèlement sur les deux écosystèmes a pour but d’illustrer différents indices de biodiversité nécessaires à la prise de décision en matière de conservation ou de développement durable de la biodiversité insulaire et de réaliser un état de référence pour établir un diagnostic sur l’état de la biodiversité. La représentation cartographique des indices à l’aide d’un SIG, illustrée dans cette étude avec la richesse spécifique terrestre et marine, permet une lecture intuitive et rapide de la variabilité de cet indice dont la restitution est basée sur une standardisation du nombre d’espèces. Cette approche méthodologique développée sur l’île de Moorea pourrait servir de modèle pour d’autres îles tropicales
EISSN: 2429-6422

hal-01306285
https://hal-univ-perp.archives-ouvertes.fr/hal-01306285

Éditeur(s) : HAL CCSD American Geophysical Union
Résumé : International audience
This study investigates three-dimensional flow modes of orogenic plateaus by means of physical modeling. Experiments consist of shortening two contiguous lithospheres of contrasting strength, one being a weak plateau-type lithosphere and the other a strong craton-type lithosphere. The lateral boundaries are either totally confined or allow escape toward a lateral foreland on one side. Two synconvergence flow regimes are distinguished, which are governed by the balance between the gravity potential and the strength of the plateau crust and the resistance of its lateral foreland. The first regime implies transversal (orogen-normal) injection of plateau lower crust into the collision zone as a result of confinement of the plateau by an increasingly stiffer lateral boundary. As a precursor mechanism to channel flow, transversal injection responds to downward thickening of the plateau crust that is forcedly extruded into the orogenic wedge. The second regime is that of collapse-driven lateral escape of the plateau. This regime is established after a threshold is attained in the interplate coupling in the collision zone, which allows the gravity potential of the plateau to overcome the resistance of its lateral boundary. Under the collapse-driven escape regime (orogen parallel), such as that governing Tibet during the last 13 Ma, most of the convergence in the plateau and the top and rear of the collisional wedge is transformed into lateral flow and extension.
ISSN: 0148-0227

hal-01229107
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01229107
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01229107/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01229107/file/2015JB012110_revised.pdf
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01229107/file/SupplementaryMaterial_final.pdf

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
The capacity of testicular somatic cells to promote and sustain germ cell differentiation is largely regulated by sexual steroids and notably androgens. In fish species the importance of androgens is emphasized by their ability to induce sex reversal of the developing fries and to trigger spermatogenesis. Here we studied the influence of androgens on testicular gene expression in trout testis using microarrays. Following treatment of immature males with physiological doses of testosterone or 11-ketotestosterone, 418 genes that exhibit changes in expression were identified. Interestingly, the activity of testosterone appeared stronger than that of 11-ketotestosterone. Expression profiles of responsive genes throughout testis development and in isolated germ cells confirmed androgens to mainly affect gene expression in somatic cells. Furthermore, specific clusters of genes that exhibit regulation coincidently with changes in the natural circulating levels of androgens during the reproductive cycle were highlighted, reinforcing the physiological significance of these data. Among somatic genes, a phylogenetic footprinting study identified putative androgen response elements within the proximal promoter regions of 42 potential direct androgen target genes. Finally, androgens were also found to alter the germ line towards meiotic expression profiles, supporting the hypothesis of a role for the somatic responsive genes in driving germ cell fate. This study significantly increases our understanding of molecular pathways regulated by androgens in vertebrates. The highly cyclic testicular development in trout together with functions associated with regulated genes reveal potential mechanisms for androgen actions in tubule formation, steroid production, germ cell development and sperm secretion.
ISSN: 1932-6203

inserm-00825763
http://www.hal.inserm.fr/inserm-00825763
http://www.hal.inserm.fr/inserm-00825763/document
http://www.hal.inserm.fr/inserm-00825763/file/Rolland_et_al.pdf
DOI : 10.1371/journal.pone.0053302