Éditeur(s) : CRILLASH : Centre de recherches interdisciplinaires en lettres, langues, arts et sciences humaines CRPLC : Centre de recherche sur les pouvoirs locaux dans la Caraïbe CEREGMIA : Centre d'études et de recherche en économie, gestion et modélisation informatique appliquée CRILLASH : Centre de recherches interdisciplinaires en lettres, langues, arts et sciences humaines

Droits : Document protégé par le droit d'auteur
fichiers:HASH8c9fca15ab53b3508914eb

Éditeur(s) : CRILLASH : Centre de Recherches Interdisciplinaires en Lettres, Langues, Arts et Sciences Humaines CRPLC : Centre de Recherche sur les Pouvoirs Locaux dans la Caraïbe CEREGMIA : Centre d'Etudes et de Recherche en Economie, Gestion et Modélisation Informatique Appliquée
Extrait de : "Les diasporas du nouveau monde" : symposium international des jeunes chercheurs de la Caraïbe, les 21 et 22 janvier 2010. Université des Antilles et de la Guyane

Droits : CC-BY-NC-ND - Attribution - Pas d'utilisation commerciale - Pas de modification
Provenance : Université des Antilles et de la Guyane. Service commun de la documentation
Permalien : http://www.manioc.org/fichiers/HASH8c9fca15ab53b3508914eb
HASH8c9fca15ab53b3508914eb

Éditeur(s) : Université de Guyane MINEA : Migrations, Interculturalité et Education en Amazonie
Extrait de : "Géographies de l'esclavage sur le plateau des Guyanes : héritages, mobilités, discours" : journées d'étude, les 7 et 8 juin 2018. Université de Guyane

Droits : CC-BY-NC-ND - Attribution - Pas d'utilisation commerciale - Pas de modification
Permalien : http://www.manioc.org/fichiers/V18288
V18288

Éditeur(s) : CRILLASH : Centre de Recherches Interdisciplinaires en Lettres, Langues, Arts et Sciences Humaines CRPLC : Centre de Recherche sur les Pouvoirs Locaux dans la Caraïbe CEREGMIA : Centre d'Etudes et de Recherche en Economie, Gestion et Modélisation Informatique Appliquée
Extrait de : "Les diasporas du nouveau monde" : symposium international des jeunes chercheurs de la Caraïbe, les 21 et 22 janvier 2010. Université des Antilles et de la Guyane

Droits : CC-BY-NC-ND - Attribution - Pas d'utilisation commerciale - Pas de modification
Provenance : Université des Antilles et de la Guyane. Service commun de la documentation
Permalien : http://www.manioc.org/fichiers/HASHbdc061b918dfc23d436840
HASHbdc061b918dfc23d436840

Éditeur(s) : CRILLASH : Centre de recherches interdisciplinaires en lettres, langues, arts et sciences humaines CRPLC : Centre de recherche sur les pouvoirs locaux dans la Caraïbe CEREGMIA : Centre d'études et de recherche en économie, gestion et modélisation informatique appliquée CRILLASH : Centre de recherches interdisciplinaires en lettres, langues, arts et sciences humaines

Droits : Document protégé par le droit d'auteur
fichiers:HASHbdc061b918dfc23d436840

Éditeur(s) : CSIA : Comité de soutien aux Indiens des Amériques
Extrait de : Nitassinan, notre terre
Siècle(s) traité(s) : 16
Droits : Ce document est protégé par le droit d'auteur. Il ne peut en aucun cas être utilisé sans l'autorisation de l'auteur et des ayant droits
Permalien : http://www.manioc.org/recherch/T17018
T17018

Éditeur(s) : Université de Guyane MINEA : Migrations, Interculturalité et Education en Amazonie
Extrait de : "Géographies de l'esclavage sur le plateau des Guyanes : héritages, mobilités, discours" : journées d'étude, les 7 et 8 juin 2018. Université de Guyane

Droits : CC-BY-NC-ND - Attribution - Pas d'utilisation commerciale - Pas de modification
Permalien : http://www.manioc.org/fichiers/V18285
V18285

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
ISSN: 0003-4975

hal-01563338
http://hal.univ-brest.fr/hal-01563338
DOI : 10.1016/j.athoracsur.2016.03.093
PUBMED : 27262916

Éditeur(s) : Université des Antilles et de la Guyane. Faculté des lettres et sciences humaine CNFG : Comité National Français de Géographie. Comission de géographie des transports AIHP-GEODE : Archéologie Industrielle, Histoire, Patrimoine/Géographie- Développement Environnement de la Caraïbe
Extrait de : "Transports et territoires insulaires" : colloque, les 4 et 5 avril 2011. Université des Antilles et de la Guyane
Description : Deuxième débat de la séance "Dessertes inter-îles ; circulation intra-insulaire" entre les intervenants et le public.
Siècle(s) traité(s) : 21
Droits : CC-BY-NC-ND - Attribution - Pas d'utilisation commerciale - Pas de modification
Permalien : http://www.manioc.org/fichiers/V11027
V11027

Éditeur(s) : Université des Antilles et de la Guyane. Service commun de la documentation
Extrait de : Les rencontres culturelles de la BU 2010-2011. Université des Antilles et de la Guyane
Description : La bibliothèque de l'Université des Antilles et de la Guyane a organisé le 10 mai 2011, une réflexion autour des mouvements de grèves survenus de janvier à mars 2009 en Guadeloupe, en Martinique, en Guyane et à la Réunion. 38 jours de grèves en Martinique, 44 jours en Guadeloupe, accompagnés de cortèges de plusieurs milliers de manifestants dans les rues de Fort-de-France et de Pointe-à-Pitre pour dénoncer la vie chère et les bas salaires au rythme d'un chant de contestation. Chaque intervenant présente son analyse géographique, historique, sociologique et politique des évènements de 2009. Et que reste-t-il aujourd'hui de ces mouvements sociaux ? Un débat intéressant suit ces interventions.
Siècle(s) traité(s) : 21
Droits : CC-BY-NC-ND - Attribution - Pas d'utilisation commerciale - Pas de modification
Permalien : http://www.manioc.org/fichiers/V12001
V12001

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Aims: The aims of this study were to compare short-and long-term outcomes for clinical T2N0 oesophageal cancer with analysis of (i) primary surgery (S) versus neoadjuvant therapy plus surgery (NS), (ii) squamous cell carcinoma and adenocarcinoma subsets; and (iii) neoadjuvant chemoradiotherapy versus neoadjuvant chemotherapy.Methods: Data were collected from 30 European centres from 2000 to 2010. Among 2944 included patients, 355 patients (12.1%) had cT2N0 disease; 285 (S) and 70 (NS), were compared in terms of short-and long-term outcomes. Propensity score matching analyses were used to compensate for differences in baseline characteristics.Results: No significant differences between the groups were shown in terms of in hospital morbidity and mortality. Nodal disease was observed in 50% of S-group at the time of surgery, with 20% pN2/N3. Utilisation of neoadjuvant therapy was associated with significant tumour downstaging as reflected by increases in pT0, pN0 and pTNM stage 0 disease, this effect was further enhanced with neoadjuvant chemoradiotherapy. After adjustment on propensity score and confounding factors, for all patients and subset analysis of squamous cell and adenocarcinoma, neoadjuvant therapy had no significant effect upon survival or recurrence (overall, loco-regional, distant or mixed) compared to surgery alone. There were no significant differences between neoadjuvant chemotherapy and chemoradiotherapy in short-or long-term outcomes.Conclusion: The results of this study suggest that a surgery alone treatment approach should be recommended as the primary treatment approach for cT2N0 oesophageal cancer despite 50% of patients having nodal disease at the time of surgery.
ISSN: 0959-8049

hal-01666517
https://hal.univ-lorraine.fr/hal-01666517
DOI : 10.1016/j.ejca.2015.11.024

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Two of the crucial aspects of human immunodeficiency virus (HIV) infection are (i) viral persistence in reservoirs (precluding viral eradication) and (ii) chronic inflammation (directly associated with all-cause morbidities in antiretroviral therapy (ART)-controlled HIV-infected patients). The objective of the present study was to assess the potential involvement of adipose tissue in these two aspects. Adipose tissue is composed of adipocytes and the stromal vascular fraction (SVF); the latter comprises immune cells such as CD4+ T cells and macrophages (both of which are important target cells for HIV). The inflammatory potential of adipose tissue has been extensively described in the context of obesity. During HIV infection, the inflammatory profile of adipose tissue has been revealed by the occurrence of lipodystrophies (primarily related to ART). Data on the impact of HIV on the SVF (especially in individuals not receiving ART) are scarce. We first analyzed the impact of simian immunodeficiency virus (SIV) infection on abdominal subcutaneous and visceral adipose tissues in SIVmac251 infected macaques and found that both adipocytes and adipose tissue immune cells were affected. The adipocyte density was elevated, and adipose tissue immune cells presented enhanced immune activation and/or inflammatory profiles. We detected cell-associated SIV DNA and RNA in the SVF and in sorted CD4+ T cells and macrophages from adipose tissue. We demonstrated that SVF cells (including CD4+ T cells) are infected in ART-controlled HIV-infected patients. Importantly, the production of HIV RNA was detected by in situ hybridization, and after the in vitro reactivation of sorted CD4+ T cells from adipose tissue. We thus identified adipose tissue as a crucial cofactor in both viral persistence and chronic immune activation/inflammation during HIV infection. These observations open up new therapeutic strategies for limiting the size of the viral reservoir and decreasing low-grade chronic inflammation via the modulation of adipose tissue-related pathways
ISSN: 1553-7366

Droits : http://creativecommons.org/licenses/by/
hal-01207287
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01207287
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01207287/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01207287/file/journal.ppat.1005153.pdf
DOI : 10.1371/journal.ppat.1005153

Éditeur(s) : Amer Geophysical Union
Résumé : The freshest surface waters in the tropical Pacific are found at its eastern boundary. Using in situ observations, we depict the quasi-permanent presence of a far eastern Pacific fresh pool with Sea Surface Salinity (SSS) lower than 33, which is confined between Panama's west coast and 85W in December and extends westward to 95W in April. Strong SSS fronts are found at the outer edge of this fresh pool. We investigate the seasonal dynamics of the fresh pool using complementary satellite wind, rain, sea level and in situ oceanic current data at the surface, along with hydrographic profiles. The fresh pool appears off Panama due to the strong summer rains associated with the northward migration of the ITCZ over Central America in June. During the second half of the year, the eastward-flowing North Equatorial Counter Current keeps it trapped to the coast and strengthens the SSS front on its western edge. During winter, as the ITCZ moves southward, the north-easterly Panama gap wind creates a south-westward jet-like current in its path with a dipole of Ekman pumping/eddies on its flanks. As a result, upwelling in the Panama Bight brings to the surface cold and salty waters which erode the fresh pool on its eastern side while both the jet current and the enhanced South Equatorial Current stretch the fresh pool westward until it nearly disappears in May. New SMOS satellite SSS data proves able to capture the main seasonal features of the fresh pool and monitor its spatial extent.
Journal Of Geophysical Research-oceans (0148-0227) (Amer Geophysical Union), 2012-04 , Vol. 117 , P. -

Droits : 2012 AGU
http://archimer.ifremer.fr/doc/00072/18311/16581.pdf
DOI:10.1029/2011JC007802
http://archimer.ifremer.fr/doc/00072/18311/

Éditeur(s) : Université des Antilles et de la Guyane. Faculté des lettres et sciences humaine AIHP-GEODE : Archéologie Industrielle, Histoire, Patrimoine/Géographie- Développement Environnement de la Caraïbe CNFG : Comité National Français de Géographie. Comission de géographie des transports
Extrait de : "Transports et territoires insulaires" : colloque, les 4 et 5 avril 2011. Université des Antilles et de la Guyane
Description : Monsieur Thierry Nicolas s'interroge sur les inégalités en matière de désenclavement dans les petites Antilles. Et quels sont les facteurs contribuant à cette différenciation spatiale des îles des petites Antilles comme la Guadeloupe et la Martinique.
Siècle(s) traité(s) : 20
Droits : CC-BY-NC-ND - Attribution - Pas d'utilisation commerciale - Pas de modification
Permalien : http://www.manioc.org/fichiers/V11022
V11022

Éditeur(s) : HAL CCSD
Résumé : International audience
INTRODUCTION: The syndrome of combined pulmonary fibrosis and emphysema (CPFE) is characterized by imaging features consisting of the association of centrilobular and/or paraseptal emphysema and pulmonary fibrosis. Virtually all patients are smokers and thus at high risk of developing lung cancer. METHODS: This retrospective multicentre study was conducted by the Groupe d'Etudes et de Recherche sur les Maladies "Orphelines" Pulmonaires (GERM"O"P). RESULTS: A total of 47 patients presenting with lung cancer and CPFE syndrome were identified. All patients were smokers, with a mean of 47 pack-years. A pathological diagnosis of lung cancer was obtained for 38 (81%) patients. Histological type was squamous cell carcinoma in 17 (36%) patients, adenocarcinoma in 14 (30%), non-small-cell lung cancer not otherwise specified in three (6%), small-cell lung cancer in three (6%), and sarcomatoid carcinoma in one (2%). Overall, 20 of the 47 patients could not receive standard-of-care treatment for lung cancer, as per international recommendations or guidelines; this limitation was considered to be directly related to the CPFE syndrome in eight (40%) cases. CONCLUSION: Lung cancer in patients with CPFE syndrome represents a specific entity with a poor prognosis, that further represents the most characteristic and severe model of tobacco-related disease.
Journal of Thoracic Oncology: Official Publication of the International Association for the Study of Lung Cancer

hal-01063912
https://hal.archives-ouvertes.fr/hal-01063912
DOI : 10.1097/JTO.0000000000000209
PUBMED : 25157769

Éditeur(s) : HAL CCSD
Résumé : International audience
In the external Western Alps, the collision started with the shortening of the proximal European (Dauphinois) margin. One peculiar feature is the crustal thickening that finally led to the exhumation of the basement External Crystalline Massifs (ECM) during the Neogene. In these massifs, various age of shortening, structural style and sequence of deformation have been proposed leading to different kinematics along the Alpine arc that in turn do not imply the same crustal/lithospheric strength. In this contribution, we present new structural and microstructural data along with Ar/Ar ages from field studies in the Oisans-Grandes Rousses massifs, between Grenoble and Briançon). From balanced cross-sections, we show that about half of the external zone crustal shortening is accommodated within the ECM with similar Ar/Ar ages in all massifs. Furthermore, the shear zones present very large thicknesses (several hundred meters) and do not reactivated either the inherited Liassic normal faults or the Variscan foliation. Finally, the main shortening structures are localized beneath inherited Liassic syn-rift basins. These results suggest that the crust was weak during its shortening. Such behavior is most likely due to the combination of several factors: the crust burial (below the overthrusting internal units) down to about 10km, the presence of weak inherited syn-rift basins, and the strain softening in shear zones that evolve in mica-rich phyllonites. These results are consistent with the studies in the Aar massif and should most likely apply to the Mont Blanc massif, whose relationships with its cover are still debated.
EGU General Assembly
Vienne, Austria

insu-00839426
https://hal-insu.archives-ouvertes.fr/insu-00839426
BIBCODE : 2013EGUGA..15.8837B

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
o abstract
ISSN: 0306-4530

hal-01390972
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01390972
DOI : 10.1016/j.psyneuen.2016.07.096

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The Liver X Receptors (LXRs) α and β and the Peroxisome Proliferator-Activated Receptor α (PPARα) are transcription factors that belong to class II nuclear receptors. They drive the expression of genes involved in hepatic lipid homeostasis and therefore are important targets for the prevention and treatment of nonalcoholic fatty liver disease (NAFLD). LXRs and PPARα are regulated by endogenous ligands, oxysterols and fatty acid derived molecules, respectively. In the liver, pharmacological activation of LXRs leads to the over-expression of genes involved in de novo lipogenesis, while PPARα is critical for fatty acid catabolism in nutrient deprivation. Even if these two nuclear receptors seemed to play opposite parts, recent studies have highlighted that PPARα also influence the expression of genes involved in fatty acids synthesis. In this study, we used pharmacological approaches and genetically engineered mice to investigate the cross-talk between LXRs and PPARα in the regulation of genes responsible for lipogenesis. We first investigated the effect of T0901317 and fenofibrate, two synthetic agonists of LXRs and PPARα, respectively. As expected, T0901317 and fenofibrate induce expression of genes involved LXR-dependent and PPARα-dependent lipogenic responses. Considering such overlapping effect, we then tested whether LXR agonist may influence PPARα driven response and vice versa. We show that the lack of PPARα does not influence the effects of T0901317 on lipogenic genes expression. However, PPARα deficiency prevents the up-regulation of genes involved in ω-hydroxylation that are induced by the LXR agonist. In addition, over-expression of lipogenic genes in response to fenofibrate is decreased in LXR knockout mice as well as the expression of PPARα target genes involved in fatty acid oxidation. Altogether, our work provides in vivo evidence for a central interconnection between nuclear receptors that drive hepatic lipid metabolism in response to oxysterol and fatty acids.
ISSN: 0300-9084

inserm-00872582
http://www.hal.inserm.fr/inserm-00872582
DOI : 10.1016/j.biochi.2012.09.028
PUBMED : 23063693

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The Oisans Massif, located in the external zones of the western Alps, experienced significant shortening during the Alpine collision. While a series of major top-to-the west shear zones was recently described, the general low grade of the metamorphism has not attracted much petrological and geochronological studies. This paper provides combined temperature and age constraints on the evolution of the Oisans Massif. Temperature was estimated with the Raman Spectrometry of Carbonaceous Material (RSCM) method and chlorite geothermometry. Maximum temperature reached by the Mesozoic cover (Tmax) from Grenoble to the Galibier pass (E-W) and from Saint Jean de Maurienne to Embrun (N-S) yielded almost constant ca. 330 °C temperatures all through the Massif. Temperatures however strongly decrease either westward towards the top of the Vercors sedimentary sequence or eastward towards the Penninic Frontal Thrust. Age constraints were retrieved using 40Ar/39Ar in situ analyses performed on variously strained samples from Alpine shear zones. Over strain gradients, incipient Alpine recrystallizations progressively develop at the expense of former Variscan parageneses. A combined textural and EPMA approach permitted to identify newly formed chlorite and phengite that unequivocally grew in response to deformation or to low grade metamorphism. Chlorites recorded temperatures from ca. 350–150 °C during the activity of shear zones. In parallel, 40Ar/39Ar in situ experiments enabled dating deformation using both synkinematic phengites crystallized below the closure temperature of white-micas and former Variscan muscovite whose isotopic system have been, at least partially re-opened. Activity of top-to-the-west shear zones responsible for the shortening and thickening of the Oisans massif thus occurred between 34 and 33 and 25 Ma. Integrating these new age-constraints, Tmax estimates, and published geological data on the Oisans Massif and neighbouring areas allow proposing a new shortening scenario for the external zones. From ca. 34–33 Ma, the Oisans Massif was buried as a rigid block below more internal units and reached a temperature of ca. 330 °C. Shearing progressively localized along a series of top-to-the-W shear zones in the basement until 25 Ma. Deformation then localized along a major thrust at the base of the ECM massif and propagated along the basement-cover interface below the Vercors massif after 16 Ma.
ISSN: 0264-3707

Droits : info:eu-repo/semantics/OpenAccess
insu-01093878
https://hal-insu.archives-ouvertes.fr/insu-01093878
https://hal-insu.archives-ouvertes.fr/insu-01093878/document
https://hal-insu.archives-ouvertes.fr/insu-01093878/file/GEOD1326RA.pdf
DOI : 10.1016/j.jog.2014.09.004

Éditeur(s) : HAL CCSD CRC Press
Résumé : Among the ecosystem services provided by forests, wood provisioning takes a central position. Wood and derived products have played a critical role in the evolution of human kind and demand for raw material is increasing in a foreseeable future. Wood is used for energy production, construction and a wide variety of products for which different properties are required. Anatomical, chemical and physical properties of wood are determined through a complex process called xylogenesis controlled by internal and external signals and occurring during the life of the tree. In this chapter we describe i/how wood is formed and ii/the different factors controlling this developmental process with emphasis on the molecular machinery involved, iii/the functions of wood and iv/the biotechnology approaches developed to improve wood biomass production and properties genetically.
Tree Biotechnology

ISBN : 978-1466597143
hal-01032436
https://hal.archives-ouvertes.fr/hal-01032436