Éditeur(s) : HAL CCSD American Public Health Association
Résumé : International audience
BACKGROUND: It is well established that high adherence to HIV-infected patients on highly active antiretroviral treatment (HAART) is a major determinant of virological and immunologic success. Furthermore, psychosocial research has identified a wide range of adherence factors including patients' subjective beliefs about the effectiveness of HAART. Current statistical approaches, mainly based on the separate identification either of factors associated with treatment effectiveness or of those associated with adherence, fail to properly explore the true relationship between adherence and treatment effectiveness. Adherence behavior may be influenced not only by perceived benefits-which are usually the focus of related studies-but also by objective treatment benefits reflected in biological outcomes. METHODS: Our objective was to assess the bidirectional relationship between adherence and response to treatment among patients enrolled in the ANRS CO8 APROCO-COPILOTE study. We compared a conventional statistical approach based on the separate estimations of an adherence and an effectiveness equation to an econometric approach using a 2-equation simultaneous system based on the same 2 equations. RESULTS: Our results highlight a reciprocal relationship between adherence and treatment effectiveness. After controlling for endogeneity, adherence was positively associated with treatment effectiveness. Furthermore, CD4 count gain after baseline was found to have a positive significant effect on adherence at each observation period. This immunologic parameter was not significant when the adherence equation was estimated separately. In the 2-equation model, the covariances between disturbances of both equations were found to be significant, thus confirming the statistical appropriacy of studying adherence and treatment effectiveness jointly. CONCLUSIONS: Our results, which suggest that positive biological results arising as a result of high adherence levels, in turn reinforce continued adherence and strengthen the argument that patients who do not experience rapid improvement in their immunologic and clinical statuses after HAART initiation should be prioritized when developing adherence support interventions. Furthermore, they invalidate the hypothesis that HAART leads to "false reassurance" among HIV-infected patients.
ISSN: 0025-7079

hal-00875196
https://hal.archives-ouvertes.fr/hal-00875196
DOI : 10.1097/MLR.0b013e3182422f61
PUBMED : 22362167

Résumé : Cette thèse a pour objet l'étude de la contrôlabilité à zéro de systèmes d'équations aux dérivées partielles paraboliques, que l'on rencontre en physique, chimie ou en biologie. En chimie ou en biologie, ces systèmes modélisent l'évolution au cours du temps d'une concentration chimique ou de la densité d'une population (de bactéries, de cellules). Le but de la contrôlabilité à zéro est d'amener la solution du système à l'état nul à un temps donné T, en agissant sur le système à l'aide d'un contrôle. Nous recherchons donc un contrôle, de norme minimale, tel que la solution associée y vérifie y(T)=O dans le domaine Omega considéré. Les problèmes de contrôlabilité à zéro considérés dans cette thèse sont de trois types. Dans un premier temps, nous nous intéressons à la contrôlabilité à zéro avec un nombre fini de contraintes sur la dérivée normale de l'état, pour l'équation de la chaleur semi-linéaire. Puis, nous analysons la contrôlabilité simultanée à zéro avec contrainte sur le contrôle, pour un système linéaire de deux équations paraboliques couplées. Notre dernière étude concerne la contrôlabilité à zéro d'un système non linéaire de deux équations paraboliques couplées. Nous abordons ces problèmes de contrôlabilité principalement à l'aide d'inégalités de Carleman. En effet, l'étude des problèmes de contrôlabilité à zéro, et plus généralement de contrôlabilité exacte, peut se ramener à l'établissement d'inégalités d'observabilité pour le problème adjoint, conséquences d'inégalités de Carleman. Nous construisons le contrôle optimal en utilisant la méthode variationnelle et nous le caractérisons par un système d'optimalité
This thesis is devoted to the study of the null controllability of systems of parabolic partial differential equations, which we meet in physics, chemistry or in biology. In chemistry or in biology, the se systems model the evolution in time of a chemical concentration or the density of a population (of bacteria, cells). The aim of nu Il controllability is to lead the solution of the system to zero in a given time T, by acting on the system with a control. Thus we are looking for a control, of minimal norm, such as the associated solution y satisfies y(T)=O in the domain Omega under concern. We consider three types of null controllability problems in this thesis. At first, we are interested in the null controllability with afinite number of constraints on the normal derivative of the state, for the serni-Iinear heat equation. Then, we analyze the simultaneous null controllability with constraint on the control, for a linear system of two coupled parabolic equations. Our last study deals with the null controllability ofa non linear system oftwo coupled parabolic equations. We approach these controllability problems mainly by means of Carleman's inequalities. Indeed, the study of null controllability problems, and more generally exact controllability problems, is equivalent to obtain observability inequalities for the adjoint problem, consequences of Carleman's inequalities. We build the optimal controlusing the variationnal method and we characterize it by an optimality system

http://www.theses.fr/2013AGUY0609/document

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
This paper is concerned with the simultaneous null controllability with constraint on the control, for a system of coupled linear heat equations. First, we show that, by means of a change of variable, a system of two linear heat equations with a same control can be rewritten in the form of a system of linear heat equations with a control function acting only in one equation. Then, we establish an observability inequality, and we state an appropriate Carleman estimate adapted to the constraint that we use to prove the main result.
ISSN: 0096-3003

hal-01679125
https://hal.archives-ouvertes.fr/hal-01679125
DOI : 10.1016/j.amc.2012.12.022

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Increasingly, health risk assessment is addressing multiple pathway exposures to multiple contaminants. We reviewed aggregated exposure and cumulative risk approaches for contemporary and ubiquitous semivolatile organic compounds (SVOC). We identified 22 studies aggregating exposure pathways, and 31 cumulating risk. Exposure aggregation is based on the addition of pathway-specific doses, using kinetic modeling where it exists, and classic external dose equations otherwise. In most cases, exposure is dominated by a single route or source of exposure - mainly the oral pathway - via dietary or non-dietary exposure. Preferential routes and sources of exposure are influenced by SVOC physical-chemical properties such as vapor pressure. The cumulative risk approach for contaminants is based on dose addition. Simple sum of hazard quotient (Hazard Index: HI) is the most commonly used cumulative risk assessment approach, while Relative Potency Factor (RPF) appeared to the best suited – although this calls for a level of toxicological information that limits the number of compounds that can be studied simultaneously. Where both were performed, moving from HI to more refined approach produced similar results. In conclusion, both approaches - exposure aggregation and cumulative risk - rely on simple assumptions. Nevertheless, they allow uncertainty to be reduced, in comparison with source-by-source or chemical-by-chemical approaches.
ISSN: 0013-9351

hal-01635759
https://hal.archives-ouvertes.fr/hal-01635759
https://hal.archives-ouvertes.fr/hal-01635759/document
https://hal.archives-ouvertes.fr/hal-01635759/file/Pelletier%202017%20Review%20%20rev2.pdf
DOI : 10.1016/j.envres.2017.06.022

Éditeur(s) : Gauthier-Villars
Résumé : The wind, temperature and current data collected during the joined French-USA FOCAL/SEQUAL programme carried in the equatorial Atlantic band in 1983 and 1984, allowed for the first time a simultaneous study of both the equatorial and coastal (5-degrees-N) upwellings along 4-degrees-W. At the equator, the decreases of both the surface temperature and the depth of the thermocline in boreal summer are correlated with the zonal component of the local windstress in the period band 1-2 months. This corresponds to the time required by the thermocline to lift up at 0-4-degrees-W in the presence of an easterly wind. The local wind cannot however explain the entire vertical variability of the thermal structure at 0-4-degrees-W. The correlation function shows in addition that the temperature there is highly correlated to the wind recorded at St Peter and St Paul Rocks (SPP) in the period band 0-2 months. This time scale is the one required by the Kelvin and Rossby waves to propagate along the equator through equatorial wave guide dynamics. The influence of these waves seems particularly important when considering the upward displacements of the thermocline both in February-March when the winds abruptly relax and in November-December when the wind at 0-4-degrees-W is southwesterly with no secondary negative maximum in the wind record at 1-degrees-N-29-degrees-W (SPP), contrary to the climatological wind field. The computation of the different terms of the heat equation applied to an homogeneous surface layer shows that the cooling is entirely due to vertical advection and eddy diffusion. The cooling would be more effective without the atmospheric heat flux and the horizontal advection of heat transported both by the South Equatorial Current at the surface and the southward current at the bottom of the mixed layer. At the coast, the amplitude and duration of the upwellings are not constant all along the coast: in boreal summer, they are maximum east of the two capes (Palmas and Three Pointes) while in winter the strength of the cooling is maximum in the east of Cape Palmas and then decreases eastward. The meridional slope of the thermocline off the coast concerns a distance which is much larger than the internal Rossby radius of deformation and is coherent with the latitudinal extension and intensity of the Guinea current both in summer and winter. In addition to this geostrophic adjustment, the upward tilt of the thermocline in summer is enhanced by the intensification of the component of the wind parallel to the coast. The application of a simple linear model forced with an eastward wind at that time explains the surface maximum cooling at the coast and the current distribution in both vertical and meridional directions. The two maxima of the zonal component of the Guinea current, in summer (main one) and in winter are in phase with the intensity of the vertical component of the windcurl. The application of the Sverdrup equations shows that the current speeds computed, for both seasons, are of the same order of magnitude as the speeds observed.
Oceanologica Acta (0399-1784) (Gauthier-Villars), 1991 , Vol. 14 , N. 3 , P. 223-240

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/00101/21252/18865.pdf
http://archimer.ifremer.fr/doc/00101/21252/

Éditeur(s) : Elsevier
Résumé : Previous studies conducted on the continental shelf in the Southeast Bay of Biscay influenced by Gironde waters (one of the two largest rivers on the French Atlantic coast) showed the occurrence of late winter phytoplankton blooms and phosphorus limitation of algal growth thereafter. In this context, the importance of dissolved organic phosphorus (DOP) for both algae and bacteria was investigated in 1998 and 1999 in terms of stocks and fluxes. Within the mixed layer, although phosphate decreased until exhaustion from winter to spring, DOP remained high and phosphate monoesters made up between I I to 65% of this pool. Total alkaline phosphatase activity (APA, V-max) rose gradually from winter (2-8 nM h(-1)) to late spring (100-400 nM h-1), which was mainly due to an increase in specific phytoplankton (from 0.02 to 3.0 nmol mu gC(-1) h(-1)) and bacterial APA (from 0.04 to 4.0 nmol mu gC(-1) h(-1)), a strategy to compensate for the lack of phosphate. At each season, both communities had equal competitive abilities to exploit DOP but, taking into account biomass, the phytoplankton community activity always dominated (57-63% of total APA) that of bacterial community (9-11%). The dissolved APA represented a significant contribution. In situ regulation of phytoplanktonic APA by phosphate (induction or inversely repression of enzyme synthesis) was confirmed by simultaneously conducted phosphate-enrichment bioassays. Such changes recorded at a time scale of a few days could partly explain the seasonal response of phytoplankton communities to phosphate depletion.
Journal of Experimental Marine Biology and Ecology (0022-0981) (Elsevier), 2005-05 , Vol. 318 , N. 2 , P. 213-225

Droits : 2005 Elsevier B.V. All rights reserved
http://archimer.ifremer.fr/doc/2005/publication-608.pdf
DOI:10.1016/j.jembe.2004.12.017
http://archimer.ifremer.fr/doc/00000/608/

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Analog sandbox models have been set up to study the impact of syntectonic erosion on thrust wedges with one and two decollement levels. Different accretion mechanisms are activated depending on interactions between surface processes and wedge mechanics: frontal accretion, backthrusting, underthrusting and underplating due to decollement induced duplex formation at depth. These mechanisms may function simultaneously, being located at different parts across the wedge. For all the experiments, a high friction is imposed at the base of models and the volume of eroded material remains equal to the volume of newly accreted material, maintaining a constant surface slope during the shortening. Erosion limits the forward propagation of thrust wedges and favors the underthrusting of basal layers allowing duplex formation. Erosion promotes development of major backthrusts in the thrust wedges without or with one decollement, but no backthrusts was formed in the wedges with two decollements. Slow erosion allows lower extent of basal underthrusting in comparison with regular-rate erosion. Variations in the erosion taper lead to changes in duplex geometry and exhumation rate in thrust wedges with one or two decollements. The 6 degrees erosion taper promotes formation of antiformal stack at the rear part of thrust wedge, high rate of basal underthrusting and high extent of erosional removal. The cover layers are nearly completely eroded above the antiformal stack and form the synformal klippe in frontal part of thrust wedges. The 8 degrees erosion taper allows development of individual ramp-anticlines and active forward thrusting of cover layers above the decollement and low rate of basal underplating below it, with consequent low extent of erosional removal. The results of our experiments support the observations on structural evolution and erosion in the Alberta Foothills of the Canadian Rockies.
ISSN: 0040-1951

hal-00617769
https://hal.archives-ouvertes.fr/hal-00617769
DOI : 10.1016/j.tecto.2011.01.020

Éditeur(s) : HAL CCSD
Résumé : International audience
Increasingly, health risk assessment is addressing multiple pathway exposures to multiple contaminants. We reviewed aggregated exposure and cumulative risk approaches for contemporary and ubiquitous semivolatile organic compounds (SVOC). We identified 22 studies aggregating exposure pathways, and 31 cumulating risk. Exposure aggregation is based on the addition of pathway-specific doses, using kinetic modeling where it exists, and classic external dose equations otherwise. In most cases, exposure is dominated by a single route or source of exposure - mainly the oral pathway - via dietary or non-dietary exposure. Preferential routes and sources of exposure are influenced by SVOC physical-chemical properties such as vapor pressure. The cumulative risk approach for contaminants is based on dose addition. Simple sum of hazard quotient (Hazard Index: HI) is the most commonly used cumulative risk assessment approach, while Relative Potency Factor (RPF) appeared to the best suited - although this calls for a level of toxicological information that limits the number of compounds that can be studied simultaneously. Where both were performed, moving from HI to more refined approach produced similar results. In conclusion, both approaches - exposure aggregation and cumulative risk - rely on simple assumptions. Nevertheless, they allow uncertainty to be reduced, in comparison with source-by-source or chemical-by-chemical approaches.
Environmental Research

hal-01579608
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01579608
DOI : 10.1016/j.envres.2017.06.022
PUBMED : 28732321

Éditeur(s) : HAL CCSD
Résumé : The convex feasibility problem (CFP) is to find a member of the intersection of finitely many closed convex sets in Euclidean space. When the intersection is empty, one can minimize a proximity function to obtain an approximate solution to the problem. The split feasibility problem (SFP) and the split equality problem (SEP) are generalizations of the CFP. The approximate SFP (ASFP) and approximate SEP (ASEP) involve finding only approximate solutions to the SFP and SEP, respectively. We present here the SSEA, a simultaneous iterative algorithm for solving the ASEP. When this algorithm is applied to the ASFP it resembles closely, but is not equivalent to, the CQ algorithm. The SSEA involves orthogonal projection onto the given closed convex sets. The relaxed SSEA (RSSEA) is an easily implementable variant of the SSEA that uses orthogonal projection onto half-spaces at each step to solve the SEP. The perturbed version of the SSEA (PSSEA) is similar to the RSSEA, but uses orthogonal projection onto a sequence of epi-convergent closed convex sets.
https://hal.univ-antilles.fr/hal-00776640

Droits : info:eu-repo/semantics/OpenAccess
hal-00776640
https://hal.univ-antilles.fr/hal-00776640
https://hal.univ-antilles.fr/hal-00776640/document
https://hal.univ-antilles.fr/hal-00776640/file/CBAM10.pdf