Éditeur(s) : HAL CCSD American Chemical Society
Résumé : International audience
Constitutive activation of the PI3K/mTOR signaling pathway contributes to carcinogenesis and metastasis in most, if not all, breast cancers. From a chromene backbone reported to inhibit class I PI3K catalytic subunits, several rounds of chemical syntheses led to the generation of a new collection of chromologues that showed enhanced ability to kill PI3K-addicted cancer cells and to inhibit Akt phosphorylation at serine 473, a hallmark of PI3K/mTOR activation. This initial screen uncovered a chromene designated DHM25 that exerted potent antitumor activity against breast tumor cell lines. Strikingly, DHM25 was shown to be a selective and covalent inhibitor of mTOR using biochemical and cellular analyses, modeling, and a large panel of kinase activity assays spanning the human kinome (243 kinases). Finally, in vivo, this novel drug was an efficient inhibitor of growth and metastasis of triple-negative breast cancer cells, paving the way for its clinical application in oncology
ISSN: 0022-2623

hal-01187307
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01187307
DOI : 10.1021/acs.jmedchem.5b00991
PUBMED : 26237138

Éditeur(s) : HAL CCSD
Résumé : The spreading ridge subduction is an unavoidable process during the subduction-related belt elovution. The aim of this thesis concerns the evolution of the Central Patagonian Cordillera, at the latitude of the Chile triple junction, in relation with the Chile spreading ridge subduction inducing the opening of a slab-window beneath the South American plate. By a morphologic, and a structural analysis, coupled with the analysis of satelittes and topographic images, we show the influence of the slab-window development at 3 Ma on the morphostructural evolution of the Central Patagonia. During the Pliocene, the Central Patagonian Cordillera experiences a major extensional phase inducing the formation of transverse and internal depressions. Negative tectonic inversion, responsible to the rift-type topography, induces the inversion of the morphotectonic front and the disruption of the volcano-sedimentary piedmont with the rest of the Cordillera at 3 Ma. Radial extensional regime is characterized by a magnitude comprises between 800 m and 3500 meters and vertical movements are localized along polyphazed faults. We suggest that the Plio-Quaternary morphostructural evolution is related to the opening of the slab-window at 3 Ma beneath the Central Patagonia. The upwelling of asthenospheric hot mantle through the slab window induces the regional collapse of the Central Patagonian Cordillera.
La subduction d'une dorsale active sous un continent est un processus inévitable dans l'évolution des chaînes de subduction. Le travail de cette thèse concerne l'évolution de la Cordillère de Patagonie Centrale, à la latitude du point triple du Chili, en relation avec la subduction de la dorsale active du Chili induisant le développement d'une fenêtre asthénosphérique sous la plaque sudaméricaine. A l'aide d'une approche morphologique, structurale, couplée à l'analyse d'images satellites et topographiques, nous montrons l'influence de la fenêtre asthénosphérique depuis 3 Ma sur l'évolution morphostructurale de la Patagonie Centrale. Au cours du Pliocène, la Cordillère de Patagonie Centrale est marquée par une phase d'extension majeure induisant la formation de dépressions transverses et internes à la chaîne. L'inversion négative du relief responsable de la topographie générale de type rift induit l'inversion du front morphotectonique et la déconnexion du piedmont volcano-sédimentaire du reste de la Cordillère à partir de 3 Ma. L'extension radiale dont l'amplitude est comprise entre 800 mètres et 3500 mètres, se localise dans la plupart des cas au niveau de failles polyphasées. L'évolution morphostructurale plioquaternaire proposée est directement reliée à l'ouverture de la fenêtre asthénosphérique à 3 Ma sous la Patagonie et à la remontée de matériel asthénosphérique chaud induisant la collapse régionale de la Cordillère de Patagonie Centrale.
https://tel.archives-ouvertes.fr/tel-00557618

tel-00557618
https://tel.archives-ouvertes.fr/tel-00557618
https://tel.archives-ouvertes.fr/tel-00557618/document
https://tel.archives-ouvertes.fr/tel-00557618/file/scalabrinothese.pdf

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
This study presents the geochemical composition of superficial sediment under oxic and suboxic bottom water conditions along the Chilean continental margin (SE Pacific), where evidence for benthic chemosynthetic activity associated with diffuse seeping of chemically reduced fluids has been reported. The exploration was carried out at: (1) the Chilean Triple Junction (CTJ), at a water depth of ∼2900 m, with the additional indication of hydrothermal activity near a methane-rich cold-seep area (46°S) (German et al., 2010); and (2) the El Quisco methane seep site (EQSS), at ∼340 m water depth (33°S) (Melo et al., 2007; Krylova et al., 2014). While the deeper CTJ is located within an oxic environment (dissolved oxygen in the bottom waters: 164 μM), the shallower EQSS lies within a suboxic environment (dissolved oxygen in bottom water: 23 μM), located within the lower limit of the SE Pacific oxygen minimum zone (OMZ).Pore water from short cores was analyzed for dissolved major, minor, and trace elements (Cl, Na, Mg, K, Ca, Sr, Si, B, P, Ba, Pb, Mn, Fe, Cd, U, and Mo), δ13DIC, sulfide, sulfate, and methane. The solid sediment fraction was likewise analyzed for total organic carbon (TOC), metals, and redox potential. Elevated sediment temperatures were found in superficial sediments (5–13 °C) at the CTJ site, which could be due to warm fluids associated with the proximity of the ridge, where hydrothermal vents may occur. Reduced fluids were also present here, indicated by higher Mn fluxes toward the water column even in oxidized sediments (RPD > 8 cm), which contrasted with the lower fluxes in reduced sediments of the EQSS site (RPD ∼ 2 cm). 13C-depleted DIC, anomalously low pore water Cl (∼15 ppb), and low concentrations of other major elements may be the result of dilution by fluid seeping and precipitation of major elements, producing authigenic enrichment (Ca, Mg, Sr). The fluid could also: (a) be diluted by pure water produced during methane hydrate dissociation, as observed in other cold-seep areas; and (b) correspond to clay mineral dehydration, as reported in plate subduction systems. The reducing conditions established at the CTJ conduct the Cd enrichment at a similar magnitude of that seen at the shallower suboxic site (EQSS). Evidence of chimney or vent fauna was not observed. At the EQSS, higher TOC and total sulfide contents were consistent with enhanced deposition of organic matter and reducing conditions developed in the OMZ, favoring the authigenic enrichment of Cd, U and Pb. The geochemical evidence, based only on methane concentrations and δ13DIC, is insufficient to establish the presence of methane seeps, as previously reported.
ISSN: 0079-6611

hal-01412700
https://hal.archives-ouvertes.fr/hal-01412700
DOI : 10.1016/j.pocean.2016.09.002

Résumé : Le Réseau Hydrologique Littoral Normand (RHLN) pérenne a été approuvé en 2007 par ses partenaires, avec le triple objectif (1) de maintenir le suivi de la qualité des masses d’eau et évaluer leur niveau d’eutrophisation en réponse aux réglementations (Directive Nitrate, OSPAR, DCE), (2) de poursuivre la réflexion sur la définition des indicateurs DCE, puis (3) de développer les connaissances et de fournir des données à la modélisation. Ce rapport réalise la synthèse des résultats obtenus en 2008 première année de la mise en oeuvre du RHLN pérenne. L’analyse des cycles hydrobiologiques observés au sein des différentes masses d’eau normandes en 2008 a permis de mettre en évidence le caractère analogue de cette année 2008 du point de vue météorologique par rapport à l’année 2007. Malgré cela, les précipitations n’ont pas entrainé d’apports de nutriments aussi importants qu’en 2007 le long des côtes normandes dont les stocks sont restés modérés. Cependant, les périodes de carence en azote, phosphore ou silice dans le milieu ont été de nouveau très limitées, ce qui aurait pu favoriser la croissance du phytoplancton tout au long de la période productive. Or, comme en 2007, les niveaux de biomasses chlorophylliennes sont restés relativement faibles. L’évaluation du niveau d’eutrophisation (ou plus précisément de dystrophie) des masses d’eaux normandes au moyen des indicateurs retenus dans le cadre de la DCE, a permis de conclure que sur les 19 masses d’eau suivies dans le cadre du RHLN 2008 : 14 peuvent être classées en « très bon état » (dont deux par extrapolation) ; 2 en « bon état » ; et 5 en « état moyen », au vue des indicateurs actuellement validés pour l’élément de qualité « Phytoplancton », combiné à celui des « Conditions physico-chimiques » pour l’évaluation de l’état écologique des masses d’eau.

Droits : Ifremer
http://archimer.ifremer.fr/doc/00006/11730/8404.pdf
http://archimer.ifremer.fr/doc/00006/11730/

Résumé : Nous avons étudié les phénomènes de polyploïdisation chez l'igname Dioscorea alata qui comprend trois cytotypes diploïde (2n=40), triploïde (2n=60) et tétraploïde (2n=80) en vue d'optimiser les stratégies de production d'hybrides polyploïdes. Chez ce complexe polyploïde l'augmentation de la ploïdie est corrélée avec une augmentation de la vigueur et des rendements plus élevés et plus stables. Dans un premier temps nous avons démontré l'autotétraploïdie des variétés tétraploïdes à l'aide de trois approches différentes: des analyses d'hérédité de marqueurs microsatellites, l'observation de phénomènes de double réduction et l'étude des méioses des cellules mères de pollen. Nous avons ensuite déterminé quels sont les mécanismes les plus probables à l'origine des polyploïdes naturels via l'étude de la transmission de l'hétérozygotie parentale à l'aide de microsatellites et par l'étude des incompatibilités au niveau de l'albumen lors de différents croisements intracytotypes et intercytotypes en utilisant la cytométrie en flux. Les résultats obtenus montrent que les polyploïdes de D. alata seraient apparus via la formation de gamètes non réduits de clones diploïdes. Le pool triploïde se serait édifié et diversifié uniquement par voie femelle, du fait de la non viabilité des croisements intercytotypes et de la stérilité des femelles et mâles triploïdes. Le pool tétraploïde serait apparu par union de deux gamètes non réduits de clones diploïdes (polyploidisation sexuelle bilatérale). Par la suite ce pool aurait été diversifié via des croisements intercy
We studied polyploidisation phenomena in the yam Dioscorea alata that includes three cytotypes -diploid (2n=40), triploid (2n=60) and tetraploid (2n=80) -in order to optimise polyploid hybrid production strategies. In this complex polyploid, the increase in ploidy is correlated with an increase in vigour and higher and more stable yields. We first showed the autotetraploidy of tetraploid varieties using three different approaches: heredity analyses of microsatellite markers, the observation of double reduction phenomena, and the study of meiosis of pollen mother cells. We then determined the mechanisms most likely to be at the origin of natural polyploids through the study of the transmission of parental heterozygoty using microsatellites and the study of incompatibilities at the endosperm level at the time of different intracytotypic and intercytotypic crosses using flow cytometry. The results obtained reveal that the polyploids of D. alata probably appeared through the formation of non-reduced gametes of diploid clones. The triploid pool would then have been constituted and diversified through the female pathway as a result of the non-viability of intercytotypic crosses and the sterility of female and male triploids. The tetraploid pool would have appeared as a result of the union of two non-reduced gametes of diploid clones (bilateral sexual polyploidisation). This pool would then have diversified through intercytotypic crosses with the formation of 2n gamètes through both the female and the male pathway, as well as by intracytotypic crosses within the 4X pool.

http://www.theses.fr/2012AGUY0519/document

Éditeur(s) : HAL CCSD
Résumé : In this paper we introduce k-laminar graphs a new class of graphs which extends the idea of Asteroidal triple free graphs. Indeed a graph is k-laminar if it admits a diametral path that is k-dominating. This bio-inspired class of graphs was motivated by a biological application dealing with sequence similarity networks of reads (called hereafter read networks for short). We briefly develop the context of the biological application in which this graph class appeared and then we consider the relationships of this new graph class among known graph classes and then we study its recognition problem. For the recognition of k-laminar graphs, we develop polynomial algorithms when k is fixed. For k=1, our algorithm improves a Deogun and Krastch's algorithm (1999). We finish by an NP-completeness result when k is unbounded.
https://hal.inria.fr/hal-01282715

hal-01282715
https://hal.inria.fr/hal-01282715
ARXIV : 1603.01179

Éditeur(s) : HAL CCSD American Geophysical Union
Résumé : International audience
GPS measurements adjacent to the southern Red Sea and Afar Triple Junction, indicate that the Red Sea Rift bifurcates south of 17 degrees N latitude with one branch following a continuation of the main Red Sea Rift (similar to 150 degrees Az.) and the other oriented more N-S, traversing the Danakil Depression. These two rift branches account for the full Arabia-Nubia relative motion. The partitioning of extension between rift branches varies approximately linearly along strike; north of similar to 16 degrees N latitude, extension (similar to 15 mm/yr) is all on the main Red Sea Rift while at similar to 13 degrees N, extension (similar to 20 mm/yr) has transferred completely to the Danakil Depression. The Danakil Block separates the two rifts and rotates in a counterclockwise sense with respect to Nubia at a present-day rate of 1.9 +/- 0.1 degrees/Myr around a pole located at 17.0 +/- 0.2 degrees N, 39.7 +/- 0.2 degrees E, accommodating extension along the rifts and developing the roughly triangular geometry of the Danakil Depression. Rotating the Danakil Block back in time to close the Danakil Depression, and assuming that the rotation rate with respect to Nubia has been roughly constant, the present width of the Danakil Depression is consistent with initiation of block rotation at 9.3 +/- 4 Ma, approximately coincident with the initiation of ocean spreading in the Gulf of Aden, and a concomitant similar to 70% increase in the rate of Nubia-Arabia relative motion.
ISSN: 0094-8276

hal-00475536
https://hal.archives-ouvertes.fr/hal-00475536
DOI : 10.1029/2009GL041127

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
We performed forward modelling of seismic anisotropy beneath a migrating strike-slip plate boundary to: (1) test if such a geodynamic context might explain teleseismic shear wave splitting data in the vicinity of the central part of the San Andreas Fault and (2) constrain the power of such data to unravel vertical and lateral variations in deformation patterns in the upper mantle. The modelling involves five steps: (1) thermomechanical modelling, using a finite-element code, of the deformation field, (2) viscoplastic self-consistent modelling of the resulting olivine and pyroxene crystal preferred orientations, (3) calculation of the elasticity tensors for different domains of the finite elements (FEs) model, (4) forward modelling of seismic wave propagation through the model using ray theory, finite-frequency theory and a full-wave approach and (5) performing splitting measurements on the synthetic seismograms. SKS splitting data in central California are best fitted by a model with a hotter geotherm within 60 km of the plate boundary accounting for the opening of an asthenospheric window due to the northward migration of the Mendocino Triple Junction. The westward motion of the plate boundary cannot however explain the rotation of fast polarization directions east of the San Andreas Fault in central California. Comparison between modelled and measured individual shear wave splitting also implies that the homogeneity of the two-layer models accounting for the observations in the vicinity of the San Andreas Fault indicates a sharp transition between lithospheric and asthenospheric deformations beneath this plate boundary. The ability of different synthetic approaches to localize horizontally and vertically the plate boundary-related deformation differs significantly. Splitting in ray theory synthetics closely follow variations in olivine crystallographic preferred orientations in the model. In contrast, splitting analysis on full-wave synthetics, which should be more representative of actual long-period SKS waves, results in smooth apparent lateral variations of anisotropy; the exact location and width of the plate boundary may only be retrieved by comparing fast-polarization profiles obtained using a multichannel analysis on waves with different periods.
ISSN: 0956-540X

hal-01236150
http://hal.univ-reunion.fr/hal-01236150
http://hal.univ-reunion.fr/hal-01236150/document
http://hal.univ-reunion.fr/hal-01236150/file/Bonnin_San_Andreas_modelling_GJI2012.pdf
DOI : 10.1111/j.1365-246X.2012.05650.x

Éditeur(s) : HAL CCSD Geological Society of America
Résumé : International audience
We present a regional model of plate geometry and kinematics of Southeast Asia since the Late Cretaceous, embedded in a global plate model. The model involves subduction polarity reversals and sheds new light on the origin of the subduction polarity reversal currently observed in Taiwan. We show that this subduction zone reversal is inherited from subduction of the proto–South China Sea plate and owes its current location to triple junction migration and slab rollback. This analysis sheds new light on the plate tectonic context of the Taiwan orogeny and questions the hypothesis that northern Taiwan can be considered an older, more mature equivalent of southern Taiwan.
ISSN: 0091-7613

hal-01397683
https://hal.archives-ouvertes.fr/hal-01397683
DOI : 10.1130/G37821.1

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/2003/rapport-2077.pdf
http://archimer.ifremer.fr/doc/00000/2077/

Éditeur(s) : Université de Bretagne Occidentale
Résumé : Le plateau des Açores est une région volcanique située à 38°N-30°W dans l'océan Atlantique nord. Il se trouve à une profondeur d'eau moyenne comprise entre 1000 et 2000 mètres et se caractérise par la présence de 8 îles volcaniques, d'une dizaine de petits segments de dorsale et par une activité hydrothermale. Il constitue une triple limite de plaque entre l'Amérique, l'Europe et l'Afrique. L'éloignement des continents et sa localisation dans le gyre subtropical en font, vis à vis de l'Atlantique nord, une région à faibles apports terrigènes et biogènes. Il se situe également au sud de limite d'extension du front polaire (42°N) lors des époques glaciaires, et n'est pas soumis à la forte variabilité climatique de l'Atlantique nord.

Droits : UBO
http://archimer.ifremer.fr/doc/00034/14505/11847.pdf
http://archimer.ifremer.fr/doc/00034/14505/

Éditeur(s) : HAL CCSD
Résumé : International audience
Background: Geographical disparities in breast cancer incidence and outcomes are reported worldwide. Women of African descent show lower incidence, higher mortality rates and earlier age of onset. We analyzed data from the cancer registry of Guadeloupe for the period 2008-2013. Methods: We describe breast cancer characteristics by molecular subtype, as well as estimated observed and net survival. We used Cox proportional hazard models to determine associations between cancer subtypes and death rate, adjusted for variables of interest. Results: Overall, 1275 cases were recorded with a mean age at diagnosis of 57(+/- 14) years. World standardized incidence and mortality were respectively 71.9/100,000 and 14.1/100,000 person-years. Age-specific incidence rates were comparable to European and US populations below the age of 45, and higher in Guadeloupean women aged between 45 and 55 years. Overall, 65.1% of patients were hormone receptor (HR)+ and 20.1% were HR-. Triple negative breast cancers (TNBC) accounted for 14% of all cases, and were more frequent in patients under 40 (21.6% vs. 13.4%, p = 0.02). Five-year net survival was 84.9% [81.4-88.6]. It was higher for HR+/Her2+ and HR+/Her2-subtypes, and lower for HR-/Her2+ and TNBC patients. Conclusion: We found high age-specific incidence rates of breast cancer in women aged 45 to 55 years, which warrants further investigation in our population. However, this population of mainly African descent had good overall survival rates, and data according to subtypes are consistent with those reported internationally. These results may suggest that poorer survival in other African descent populations may not be an inherent feature of the disease but may be amenable to improvement. (C) 2017 Elsevier Ltd. All rights reserved.
Cancer Epidemiology

hal-01519252
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01519252
DOI : 10.1016/j.canep.2017.01.004
PUBMED : 28119121

Éditeur(s) : HAL CCSD Wiley-Blackwell
Résumé : International audience
We explore the tectono-magmatic processes in the western West Philippine Basin, Philippine Sea Plate, using bathymetric data acquired in 2003 and 2004. The northwestern part of the basin formed through a series of northwestward propagating rifts. We identify at least five sequences of propagating rifts, probably triggered by mantle flow away from the mantle thermal anomaly that is responsible for the origin of the Benham and Urdenata plateaus. Gravitational forces caused by along-axis topographic gradient and a ∼30° ridge reorientation appear to also be driving the rift propagations. The along-axis mantle flow appears to be reduced and deflected along the Luzon-Okinawa fracture zone, because the spreading system remained stable west of this major fault zone. North-east of the Benham plateau, a left-lateral fracture zone has turned into a NE–SW-trending spreading axis. As a result, a microplate developed at the triple junction.
ISSN: 0954-4879

insu-00304360
https://hal-insu.archives-ouvertes.fr/insu-00304360
DOI : 10.1111/j.1365-3121.2008.00824.x

Éditeur(s) : HAL CCSD American Geophysical Union
Résumé : International audience
[1] Based on geological and geophysical data collected from the West Philippine Basin and its boundaries, we propose a comprehensive Cenozoic history of the basin. Our model shows that it is a back arc basin that developed between two opposed subduction zones. Rifting started around 55 Ma and spreading ended at 33/30 Ma. The initial spreading axis was parallel to the paleo-Philippine Arc but became inactive when a new spreading ridge propagated from the eastern part of the basin, reaching the former one at an R-R-R triple junction. Spreading occurred mainly from this second axis, with a quasi-continuous counterclockwise rotation of the spreading direction. The Gagua and Palau-Kyushu ridges acted as transform margins accommodating the opening. Arc volcanism occurred along the Palau-Kyushu Ridge (eastern margin) during the whole opening of the basin, whereas the paleo-Philippine Arc decreased its activity between 43 and 36 Ma. The western margin underwent a compressive event in late Eocene-early Oligocene time, leading to the rising of the Gagua Ridge and to a short subduction episode along Eastern Luzon. In the western part of the basin, the spreading system was highly disorganized due to the presence of a mantle plume. Overlapping spreading centers and ridge jumps occurred toward the hot region and a microplate developed. Shortly after the end of the spreading, a late stage of amagmatic extension occurred between 30 and 26 Ma in the central part of the basin, being responsible for the deep rift valley that cut across the older spreading fabric. Citation: Deschamps, A., and S. Lallemand, The West Philippine Basin: An Eocene to early Oligocene back arc basin opened between two opposed subduction zones,
ISSN: 2169-9313

hal-01261388
https://hal.archives-ouvertes.fr/hal-01261388
https://hal.archives-ouvertes.fr/hal-01261388/document
https://hal.archives-ouvertes.fr/hal-01261388/file/DeschampsJGR2002.pdf
DOI : 10.1029/2001JB001706