Éditeur(s) : HAL CCSD American Geophysical Union (AGU)
Résumé : International audience
The Calabro-Peloritan belt constitutes the eastward termination of the southern segment of the Alpine Mediterranean belt. This orogenic system was built up during the convergence between the Eurasian and the African plates, roughly directed North-South since the Upper Cretaceous. It was subsequently fragmented during the opening of the Western Mediterranean basins since Oligocene times. The curved shape of the Calabro-Peloritan belt was acquired during the opening of the Tyrrhenian basin since Tortonian. The origin, kinematics and significance of the Calabro-Peloritan tectonic pile are still debated. Our data in the Aspromonte Massif of Southern Calabria reveal an Alpine history marked by two main superimposed kinematic regimes. (i) A first phase corresponds to the piling up of basement nappes with a top-to-the-SE vergence, i.e in a direction orthogonal to the belt trend and towards the Adriatic foreland. This external vergence is similar to what is observed in both Northeastern Sicily and Northern Calabria. In Sicily, the age of nappe piling is Alpine, as evidenced by pinched slices of Mesozoïc sediments. In the Aspromonte Massif, thrusting age is less constrained. Our data suggest remnants of late Hercynian structuration before the Alpine stacking. (ii) A second phase corresponds to the thinning of the continental crust, dated at around 30 Ma by both geochronological and stratigraphical data. This extension is mainly localized on two low-angle detachment contacts, with top-to-the-NE displacement. The lower one corresponds to the reworking of the former main nappe contact. The upper one is a large detachment fault cutting across the pile from upper sedimentary levels down to metamorphic basement. Extension of similar Alpine age and similar internal vergence has been already recognized in other parts of the Calabro-Peloritan Arc: in the basement nappes of Northeastern Sicily and in the ophiolitic units of Northern Calabria. Coming back to the original geometry and position of the Calabro-Peloritan belt, before its bending and the opening of the Liguro-Provençal and Tyrrhenian basins, we evidence a homogeneous Oligocene NE-SW extension all along the Calabro-Peloritan segment of the Alpine Mediterranean belt. This tectonometamorphic history is best explained within the framework of the continuous Tertiary westward dipping subduction of the Tethyan oceanic domain below the European active margin and the progressive eastward retreat of the Apennine trench since Oligocene times.
ISSN: 0278-7407

hal-00283182
https://hal.archives-ouvertes.fr/hal-00283182
https://hal.archives-ouvertes.fr/hal-00283182/document
https://hal.archives-ouvertes.fr/hal-00283182/file/Heymes_et_al_2008.pdf
DOI : 10.1029/2007TC002157

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
Persistent organic pollutants have not been conclusively associated with length of gestation or with preterm birth. Chlordecone is an organochlorine pesticide that has been extensively used to control the banana root borer population in the French West Indies. Data from the Timoun Mother-Child Cohort Study conducted in Guadeloupe between 2004 and 2007 were used to examine the associations of chlordecone concentrations in maternal plasma with the length of gestation and the rate preterm birth in 818 pregnant women. Data were analyzed using multivariate linear regression for length of gestation and a Cox model for preterm birth. The median plasma chlordecone concentration was 0.39 µg/L (interquartile range, 0.18-0.83). No correlation was observed with plasma concentrations of p,p'-dichlorodiphenyl dichloroethene (ρ = 0.017) or polychlorinated biphenyl 153 (ρ = -0.016), the other main organochlorine compounds detected. A 1-log10 increase in chlordecone concentration was associated with a decreased length of gestation (-0.27 weeks; 95% confidence interval: -0.50, -0.03) and an increased risk of preterm birth (60%; 95% confidence interval: 10, 130). These associations may result from the estrogen-like and progestin-like properties of chlordecone. These results are of public health relevance because of the prolonged persistence of chlordecone in the environment and the high background rate of preterm births in this population.
ISSN: 0002-9262

hal-01010740
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01010740
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01010740/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01010740/file/Chlordecone%20Exposure%20final.pdf
DOI : 10.1093/aje/kwt313

Éditeur(s) : HAL CCSD American Chemical Society
Résumé : International audience
Chlordecone is an organochlorine pesticide that was extensively used in the French West Indies to fight weevils in banana plantations from 1973 to 1993. This has led to a persistent pollution of the environment and to the contamination of the local population for several decades with effects demonstrated on human health. Chlordecone accumulates mainly in the liver where it is known to potentiate the action of hepatotoxic agents. However, there is currently no information on its in situ localization in the liver. We have thus evaluated a matrix-assisted laser desorption ionization (MALDI) imaging quantification method based on labeled normalization for the in situ localization and quantification of chlordecone. After validating the linearity and the reproducibility of this method, quantitative MALDI imaging was used to study the accumulation of chlordecone in the mouse liver. Our results revealed that normalized intensities measured by MALDI imaging could be first converted in quantitative units. These quantities appeared to be different from absolute quantities of chlordecone determined by gas chromatography (GC), but they were perfectly correlated (R(2) = 0.995). The equation of the corresponding correlation curve was thus efficiently used to convert quantities measured by MALDI imaging into absolute quantities. Our method combining labeled normalization and calibration with an orthogonal technique allowed the in situ absolute quantification of chlordecone by MALDI imaging. Finally, our results obtained on the pathological mouse liver illustrate the advantages of quantitative MALDI imaging which preserves information on in situ localization without radioactive labeling and with a simple sample preparation.
ISSN: 0003-2700

hal-01118103
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118103
PUBMED : 24837422
DOI : 10.1021/ac500313s

Éditeur(s) : HAL CCSD Cambridge University Press (CUP)
Résumé : International audience
ISSN: 1431-9276

hal-01680427
https://hal.univ-antilles.fr/hal-01680427
DOI : 10.1017/S1431927614010654

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
BACKGROUND: Recent studies suggest that a Mediterranean dietary pattern during pregnancy may influence pregnancy outcomes. The aim of this study was to evaluate the effect of adherence to a Mediterranean diet (MD) during pregnancy on fetal growth restriction (FGR) and preterm delivery (PTD) in a French Caribbean island where the population is largely of African descent and presents dietary patterns similar to MD. METHODS: Using data from the TIMOUN Mother-Child Cohort Study conducted in Guadeloupe (French West Indies) between 2004 and 2007, we analysed data for 728 pregnant women who delivered liveborn singletons without any major congenital malformations. Degree of adherence to MD during pregnancy was evaluated with a semi-quantitative food frequency questionnaire based on nine dietary criteria. Multiple logistic regression models were used to analyse birth outcomes while taking potential confounders into account. RESULTS: Overall there was no association between MD adherence during pregnancy and the risk of PTD or FGR. However, pre-pregnancy body mass index was a strong effect modifier, and MD adherence was associated with a decreased risk of PTD specifically in overweight and obese women (adjusted odds ratio 0.7, 95% confidence interval 0.6, 0.9) (P heterogeneity <0.01). CONCLUSIONS: These results suggest that Caribbean diet during pregnancy may carry some benefits of MD and may contribute to reduce the risk of PTD in overweight and obese pregnant women.
ISSN: 0269-5022

hal-00988172
https://hal-univ-rennes1.archives-ouvertes.fr/hal-00988172
DOI : 10.1111/ppe.12113
PUBMED : 24754337

Éditeur(s) : HAL CCSD
Résumé : International audience
Journées internationales sur la communication, l'éduaction et la culture scientifiques et industrielles
Chamonix, France

hal-01620774
https://hal.univ-antilles.fr/hal-01620774

Éditeur(s) : HAL CCSD
Résumé : International audience
Journées internationalessur la communication, l'éducation et la culture scientifique et industrielle
chamonix, France

hal-01620769
https://hal.univ-antilles.fr/hal-01620769
https://hal.univ-antilles.fr/hal-01620769/document
https://hal.univ-antilles.fr/hal-01620769/file/Mouelhi%20et%20al_JIES%202002-FINAL.pdf

Éditeur(s) : HAL CCSD Berlin: A. Asher & Co.
Résumé : International audience
In this work, we compare IASI-retrieved vertical water vapour profiles and related precipitable water over a complex region, namely the Rhine Valley area, during the pre-operational period of IASI exploitation (June?August 2007). Both IASI water vapour mixing ratio profiles and integrated water vapour content are retrieved from L1C radiances spectra using two techniques and compared with water vapour related observations acquired during the Convective and Orographically-induced Precipitation Study (COPS) field campaign that took place in this area at that time (i.e. lidars, radiosoundings and a global positioning system - GPS - station network). This work addresses the issue of IASI vertical spatial resolution and its capability to detect two-layer water vapour structures such as those observed in a mountainous area and which play an important role in convective initiation or inhibition. We found that this capability mostly relies on the type of a-priori background vector (climatology or space-time colocated ECMWF analysis), which is used within the retrieval scheme. Systematic comparison of water vapour products derived from 71 IASI spectra confirms that IASI can retrieve water vapour amounts in 2 km width layers, in the lower troposphere, with an accuracy of approximately 10%.
ISSN: 0369-1845

hal-00923710
https://hal.archives-ouvertes.fr/hal-00923710
https://hal.archives-ouvertes.fr/hal-00923710/document
https://hal.archives-ouvertes.fr/hal-00923710/file/masiello.pdf
DOI : 10.1127/0941-2948/2013/0430

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
ISSN: 0147-6513

hal-01679434
https://hal.univ-antilles.fr/hal-01679434
DOI : 10.1016/j.ecoenv.2017.03.043

Éditeur(s) : HAL CCSD
Résumé : International audience
Critical analysis of school science textbook, International organisation for science and technology education
Hammamet, Tunisia

hal-01621796
https://hal.archives-ouvertes.fr/hal-01621796
https://hal.archives-ouvertes.fr/hal-01621796/document
https://hal.archives-ouvertes.fr/hal-01621796/file/IOSTE.pdf

Éditeur(s) : HAL CCSD
Résumé : International audience
Si la production d'énergie renouvelable solaire, éolienne et géothermique est bien développée en Guadeloupe, il n'en est pas de même de l'éducation au développement durable dont la mise en place est très récente. Issu de travaux portant sur les mécanismes de contextualisation des savoirs scientifiques, l'enquête exposée ici vise à caractériser les conceptions d'élèves de CM2 sur la géothermie en fonction du contexte géologique dans lequel ils vivent. L'impact de l'opinion de l'enseignant sur celles de ses élèves est également mis en question par le fait que les élèves ayant un enseignant impliqué de manière critique ou positive ont une opinion plus positive de l'usine géothermique voisine. La détermination de l'opinion des élèves sur cet exemple semble donc soit être plus influencée par le contexte familial que par le scolaire, soit ne se construire plus nettement, par accord ou par opposition, face à l'implication de l'enseignant. Abstract If the production of solar, wind and geothermal energy is important in Guadeloupe, it is not the same for sustainable development education. Deriving from work on the mechanisms of contextualization of scientific knowledge, the investigation presented here aims to characterize the concepts of 10 years pupils about geothermal energy as a function of geological setting in which they live. The impact of the views of the teachers on those students is also questioned. Pupils with one teacher involved in citizen group critical or positive about geothermal plant, have a more positive view of the nearby geothermal plant. The determination of students' opinions on this example seems to be more influenced by family background than by the school or not to build more significantly, by agreement or opposition, given the involvement of the teacher.
19th Caribbean Geological conference
Gosier, Guadeloupe

hal-01539490
https://hal.univ-antilles.fr/hal-01539490
https://hal.univ-antilles.fr/hal-01539490/document
https://hal.univ-antilles.fr/hal-01539490/file/FORMACOR.pdf

Éditeur(s) : HAL CCSD Nature Publishing Group
Résumé : International audience
The main familial focal epilepsies are autosomal dominant nocturnal frontal lobe epilepsy, familial temporal lobe epilepsy and familial focal epilepsy with variable foci. A frameshift mutation in the DEPDC5 gene (encoding DEP domain-containing protein 5) was identified in a family with focal epilepsy with variable foci by linkage analysis and exome sequencing. Subsequent pyrosequencing of DEPDC5 in a cohort of 15 additional families with focal epilepsies identified 4 nonsense mutations and 1 missense mutation. Our findings provided evidence of frequent (37%) loss-of-function mutations in DEPDC5 associated with a broad spectrum of focal epilepsies. The implication of a DEP (Dishevelled, Egl-10 and Pleckstrin) domain-containing protein that may be involved in membrane trafficking and/or G protein signaling opens new avenues for research.
ISSN: 1061-4036

hal-01544763
https://hal.archives-ouvertes.fr/hal-01544763
DOI : 10.1038/ng.2601

Éditeur(s) : HAL CCSD American Association for Cancer Research
Résumé : International audience
Triple-negative breast cancers (TNBC) lacking estrogen and progesterone receptors and HER2 amplification have a relatively high risk of metastatic dissemination, but the mechanistic basis for this risk is not understood. Here we report that serum levels of CD95L are higher in TNBC patients compared to other breast cancer patients. Metalloprotease-mediated cleavage of CD95L expressed by endothelial cells surrounding tumors generates a gradient that promotes cell motility, due to formation of an unconventional CD95-containing receptosome termed the motility-inducing signaling complex. Formation of this complex was instrumental for Nox3-driven ROS generation. Mechanistic investigations revealed a Yes-Orai1-EGFR-PI3K pathway that triggered migration of TNBC cells exposed to CD95L. Our findings establish a pro-metastatic function for metalloprotease-cleaved CD95L in triple-negative breast cancers, revisiting its role in carcinogenesis.
ISSN: 0008-5472

hal-00873634
https://hal.archives-ouvertes.fr/hal-00873634
PUBMED : 24072745
DOI : 10.1158/0008-5472.CAN-13-1794

Éditeur(s) : HAL CCSD
Actes du 38ème Congres Groupe Français des pesticides
Brest, France

hal-00672031
https://hal.archives-ouvertes.fr/hal-00672031

Éditeur(s) : HAL CCSD
Résumé : International audience
OBJECTIVE: To assess sperm production and aneuploidy in Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) before and after treatments. DESIGN: Multicenter, prospective, longitudinal study of lymphoma patients analyzed before treatment and after 3, 6, 12, and 24 months. SETTING: University hospitals. PATIENT(S): Forty-five HL and 13 NHL patients were investigated before and after treatment. Treatment regimens were classified in two groups: ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine) with or without (+/-) radiotherapy, and CHOP (doxorubicin, cyclophosphamide, vincristine, prednisone)/MOPP-ABV (mechlorethamine, oncovin, procarbazine, prednisone-doxorubicin, bleomycin, vinblastine). A control group of 29 healthy men was also studied. INTERVENTION(S): Semen analyses and aneuploidy study by FISH were performed at each time point. MAIN OUTCOME MEASURE(S): Comparison of mean sperm characteristics and percentage of sperm aneuploidy rates before and after treatment. RESULT(S): Before treatment, HL and NHL men had altered semen characteristics and higher sperm aneuploidy rates (median 0.76 [interquartile range 0.56-0.64]) than the control group (0.54 [0.46-0.74]). After treatment, sperm production was significantly lowered 3 and 6 months after ABVD +/- radiotherapy or CHOP/MOPP-ABV. After ABVD +/- radiotherapy, the aneuploidy rate increased significantly only at 3 months, and values obtained 1 or 2 years later were lower than pretreatment values. In contrast, in the CHOP/MOPP-ABV treatment group, semen characteristics and aneuploidy rate did not return to normal levels until 2 years after treatment. CONCLUSION(S): Lymphoma itself has consequences on sperm aneuploidy frequency before treatment. Moreover, lymphoma treatments have deleterious effects on sperm chromosomes related to treatment type and time since treatment. Patient counseling is essential concerning the transient but significant sperm aneuploidy induced by lymphoma and its treatments.
Fertility and sterility

hal-01477204
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01477204
DOI : 10.1016/j.fertnstert.2016.10.001
PUBMED : 27810161

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
ISSN: 0002-9262

hal-01010674
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01010674
DOI : 10.1093/aje/kwt315
PUBMED : 24401564

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
We sought transversotrematid trematodes from French Polynesian fishes by examining 304 individual scaled fishes of 53 species from seven families known to harbour the family elsewhere. A single species was found at two locations in the Tuamotus Archipelago on two species of Chaetodontidae (Chaetodon auriga and Chaetodon ephippium) and one species of Lutjanidae (Lutjanus gibbus). The species closely resembles Transversotrema borboleta Hunter & Cribb, 2012 from chaetodontids and lutjanids of the northern Great Barrier Reef (GBR) but differs from it consistently in 8 base positions of ITS2 rDNA. This level of variation exceeds that between some clearly morphologically distinct pairs of species of Transversotrema and the form from French Polynesia is thus interpreted as a distinct, though cryptic, species and named Transversotrema polynesiae n. sp. The new species forms part of a complex of species, here characterised as the T. borboleta complex, associated with chaetodontids and lutjanids in the tropical Indo-West Pacific. Most of the putative species within this complex are yet to be described. Comparison of identical numbers of matched samples of fishes from French Polynesia, Heron Island (southern GBR) and Lizard Island (northern GBR) revealed 1, 4 and 10 species of Transversotrema respectively suggesting that the French Polynesian fauna is depauperate for this family. In addition to those species apparently missing from suitable hosts in French Polynesia, several species from further west infect fishes (especially Nemipteridae) that are themselves absent from French Polynesia. This dramatic east–west decline in richness contrasts strongly with what is known for monogeneans, which appear to maintain their richness over the same scale, and is more precipitate than is known for other groups of trematodes. The decline might be explained in part by the absence of the as yet unknown first intermediate hosts in French Polynesia. However, we predict that it is explained by other life cycle traits. We hypothesise that the characters of large short-lived cercariae, short-lived miracidia, the absence in the life-cycle of second intermediate hosts that are capable of transporting the species, and definitive and first intermediate hosts that have limited vagility combine to give marine Transversotrematidae limited dispersal capacity and a propensity for localised speciation.
ISSN: 1383-5769

hal-01333467
https://hal-univ-perp.archives-ouvertes.fr/hal-01333467
DOI : 10.1016/j.parint.2013.11.009

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
We investigate the contribution of atmospheric and its induced non-tidal oceanic loading effects on surface time-varying gravity and tilt measurements for several stations in Western Europe. The ocean response to pressure forcing can be modelled accordingly to the inverted barometer, i.e. assuming that air pressure variations are fully compensated by static sea height changes, or using ocean general circulation models.Wevalidate two runs of theHUGO-mbarotropic ocean model by comparing predicted sea surface height variations with hundred tide-gauge measurements along the European coasts. We then show that global surface pressure field, as well as a barotropic high-resolution ocean model forced by air pressure and winds allow in most cases a significant reduction of the variance of gravity residuals and, to a smaller extends tilt residuals. Wefinally show that precise gravity measurements with superconducting gravimeters allow the observation of large storm surges, occurring in the North Sea, even for inland stations. However, we also confirm that the continental hydrology contribution cannot be neglected. Thanks to their specific sensitivity feature, only tiltmeters closest to the coast can clearly detect the loading due to these storm surges.
ISSN: 0264-3707

hal-00708046
https://hal.archives-ouvertes.fr/hal-00708046
https://hal.archives-ouvertes.fr/hal-00708046/document
https://hal.archives-ouvertes.fr/hal-00708046/file/ETS2008_BOY.pdf
BIBCODE : 2009JGeo...48..182B

Éditeur(s) : HAL CCSD
International conference on Environmental Epidemiology and Exposure ISEE/ISEA
Paris, France

hal-00697382
https://hal.archives-ouvertes.fr/hal-00697382

Éditeur(s) : Pergamon-elsevier Science Ltd
Résumé : Bivalve larvae and hydrographic parameters were sampled over a range of spatio-temporal scales in a deep atoll lagoon. Bivalve larvae abundances were very high throughout the year: 18,550 m(-3) in average. Larvae were (i) concentrated at mid-depth with nocturnal ascent and diurnal descent, (ii) heterogeneously dispersed at the lagoon scale, (iii) subject to day-to-day variation in abundance and (iv) transferred between different parts of the lagoon providing evidence of intra-lagoonal connectivity. The primacy of physical factors was seen on large spatial scale with the diluting effect of water renewal and transfers by hydrodynamics. On smaller spatial scale, the primacy of biological processes was recognised, with larval swimming activity leading to dial vertical migration correlated with food concentration. Variations in larval abundance were driven by bivalve reproductive activity correlated with meteorological conditions (i.e. windy periods). Finally, relationship between bivalve larvae patterns and pearl oyster (Pinctada margaritifera) settlement structuring is discussed. (C) 2012 Elsevier Ltd. All rights reserved.
Marine Pollution Bulletin (0025-326X) (Pergamon-elsevier Science Ltd), 2012 , Vol. 65 , N. 10-12 , P. 453-462

Droits : 2012 Elsevier Ltd. All rights reserved.
http://archimer.ifremer.fr/doc/00101/21200/20690.pdf
DOI:10.1016/j.marpolbul.2011.12.028
http://archimer.ifremer.fr/doc/00101/21200/