Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
There are emerging concerns about potential effects on child health and development of early-life exposure to substances such as brominated flame retardants (BFRs), perfluorinated compounds (PFCs), phthalates and phenols (including bisphenol A (BPA)); pregnancy and birth cohort studies are ideally designed to study such concerns prospectively. As part of the ENRIECO project, we evaluated existing human biomonitoring data for these substances in European birth cohorts and develop recommendations for more harmonized methods that will enable combination and comparison of cohort data in the future. The ENRIECO inventory shows that 20 European birth cohorts have measured or are measuring BFRs (N=10), PFCs (N=11), phthalates (N=16) or phenols (N=8). Generally, samples were collected prenatally or at birth and measurements involved few subjects in each cohort (a few hundred maximum). Biological matrices, timing, and analytical methods of the measurements varied between cohorts. Few cohorts have measured at multiple time points or in children. In European cohorts, levels of BFRs were very low and at least 10-fold lower than in US; levels of PFCs and phthalates have decreased over the last decade since the phasing out of certain of these compounds; concentrations of phenols are comparable to those in the US. Although there is little published data in the cohorts now, many measurements are ongoing and we recommend that cohorts start working towards combined and comparison studies. Specific recommendations for use of existing data include the development of conversion models for the different media used for measurement of persistent chemicals, and inter-laboratory comparisons and calibrations. Recommendations for further data collection include more evaluation of exposure to these chemicals in children; repeated measurements of non-persistent chemicals; validation and harmonisation of questionnaires; and the development of mechanisms for fast European birth cohort response for the detection and prioritisation of new chemicals of concern.
ISSN: 1438-4639

hal-01118579
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118579
DOI : 10.1016/j.ijheh.2012.05.009
PUBMED : 22795704

Éditeur(s) : HAL CCSD Geological Society of America
Résumé : International audience
The long-lived Andean subduction zone underwent several flat slab episodes and is therefore ideal to study the consequences of a complete cycle of slab flattening and steepening on the upper plate deformation pattern. In the modern Peruvian forearc (15°–17°S), slab flattening caused a Paleogene (52–30 Ma) landward migration of volcanic activity. Combining structural geology and a source-to-sink thermochronological study, we show that the flat slab period is contemporaneous with uplift accommodated by large-scale crustal extension in the forearc. In this light, we argue that the study area is an ancient analog to the modern Mexican and northern Peruvian forearcs located above modern flat slab segments and currently undergoing widespread extension.
ISSN: 0091-7613

hal-01685553
https://hal.archives-ouvertes.fr/hal-01685553
DOI : 10.1130/G38990.1

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The Longmen Shan range is one of the major topographic and structural features of the easternmargin of the Tibetan Plateau. With an impressive topographic gradient and low convergence rates across the range this region has raised important questions concerning the dynamics of plateaumargin settings, such as the long-term mechanisms of topographic evolution. The investigation of the distribution in space and time of denudation can provide critical insight into such dynamics and shed light on still unresolved controversies. For that purpose, we present a new dataset that documents the intensity and distribution of denudation processes across this plateaumargin through field survey of fluvial incision markers, quantitative geomorphology and cosmogenic nuclide derived basin-wide erosion rates. Erosion is < 0.5 mm/year in the frontal region of the Longmen Shan and between 0.5 and 1 mm/year further west, with a gradual decrease when reaching the northern headwaters of the Min Jiang watershed, adjacent to the beginning of the Tibetan Plateau. The spatialdistribution of denudation inferred from the various methods we use suggests that most of the differential uplift in the Central Longmen Shan is accommodated by the Beichuan Fault and frontal structures located in the foothills. The denudation pattern seems also to reflect the large-scale propagation of erosion from the Sichuan Basin toward the Plateau. This suggests that the Longmen Shan range is submitted to the combined influences of slow thrusting activity on the frontal structures and progressive westward regressiveerosion as a probable response to a pulse of uplift of the Tibetan PlateauEasternmargin, that started 10 Ma ago.
ISSN: 0040-1951

hal-01564192
https://hal.archives-ouvertes.fr/hal-01564192
DOI : 10.1016/j.tecto.2009.10.026

Éditeur(s) : HAL CCSD European Geosciences Union
Résumé : International audience
During the GWADASEIS cruise (Lesser Antilles volcanic arc, February-March 2009) a very high resolution (VHR) seismic-reflection survey was performed in order to constrain Late Quaternary to Present faulting. The profiles we obtained evidence frequent "ponding" of reworked sediments in the deepest areas, similar to the deposition of Mediterranean "homogenites". These bodies are acoustically transparent (few ms t.w.t. thick) and are often deposited on the hanging walls of dominantly normal faults, at the base of scarps. Their thickness appears sufficient to compensate (i.e. bury) co-seismic scarps between successive earthquakes, resulting in a flat and horizontal sea floor through time. In a selected area (offshore Montserrat and Nevis islands), piston coring (4 to 7 m long) was dedicated to a sedimentological analysis of the most recent of these particular layers. It corresponds to non-stratified homogenous calcareous silty sand (reworked calcareous plankton and minor volcanoclastics). This layer can be up to 2 m thick, and overlies finegrained hemipelagites. The upper centimeters of the latter represent the normal RedOx water/sediment interface. 210Pb and 137Cs activities lack in the massive sands, while a normal profile of unsupported 210Pb decrease is observed in the hemipelagite below, together with a 137Cs peak correspond- ing to the Atmospheric Nuclear Experiments (1962). The RedOx level was thus capped by a recent instantaneous major sedimentary event considered as post-1970 AD; candidate seismic events to explain this sedimentary deposits are either the 16 March 1985 earthquake or the 8 October 1974 one (Mw=6.3 and Mw=7.4, respectively). This leads to consider that the syntectonic sedimentation in this area is not continuous but results from accumulation of thick homogenites deposited after the earthquakes (as observed in the following weeks after Haiti January 2010 event, McHugh et al., 2011). The existence of such deposits suggests that, in the area of study, vertical throw likely results from cumulated effects of separated earthquakes rather than from aseismic creep. Examination of VHR profiles shows that all major co-seismic offsets are recorded in the fault growth sequence and that co-seismic offsets can be precisely estimated. By using a sedimentation rate deduced from 210Pb decrease curve (0.5 mm yr−1) and taking into account minor reworking events detected in cores, we show that the Redonda system may have been responsible for five >M6 events during the last 34 000 yr. The approach presented in this work differs from fault activity analyses using displaced sets of isochronous surfaces and postulating co-seismic offsets. Combining VHR seismic imagery and coring we can decipher co-seismic vs. slow continuous displacement, and thus actually estimate the amplitude and the time distribution of major co-seismic offsets.
ISSN: 1561-8633

insu-00844581
https://hal-insu.archives-ouvertes.fr/insu-00844581
https://hal-insu.archives-ouvertes.fr/insu-00844581/document
https://hal-insu.archives-ouvertes.fr/insu-00844581/file/nhess-12-1755-2012.pdf
DOI : 10.5194/nhess-12-1755-2012

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
We use 36Cl surface exposure dating to determine the slip release pattern over the last ~ 15 kyr for the Velino-Magnola fault, a major active normal fault in Central Italy. We sampled the fault at five well-separated sites along its length, and modeled the 36Cl concentrations measured in the 376 samples. We find that the fault broke in at least 9 large earthquakes that occurred in two 5-6 ka-long supercycles. Each cycle included a 4-5 ka-long phase of relative quiescence, followed by a cluster of at least 3 large earthquakes or earthquake sequences that released most of the accumulated strain in ~ 1 ka. All 9 identified events broke the entire fault and produced maximum surface slips of 2-3 m. Though the Velino-Magnola fault seems presently in a stage of relative quiescence, it may re-enter a phase of paroxysmal seismic activity in a few hundred of years
ISSN: 0012-821X

hal-00667280
https://hal.archives-ouvertes.fr/hal-00667280
DOI : 10.1016/j.epsl.2011.05.022

Éditeur(s) : HAL CCSD
Résumé : National audience
Journées IODP France
Paris, France

insu-01133126
https://hal-insu.archives-ouvertes.fr/insu-01133126

Éditeur(s) : HAL CCSD
Résumé : International audience
The aim was to identify patterns of work organization characteristics using data from epidemiological surveillance program of musculoskeletal disorders (MSD) implemented in the Pays de la Loire region between 2002 and 2005. A total of 3710 workers were included and completed a administered questionnaire including 16 organizational variables. Ascendant hierarchical clustering (AHC) of organizational variables and AHC of workers had identified five patterns of work organization characteristics: technical constraints and weak decision latitude; internal/external demand and mean decision latitude; weak pace constraints and mean decision latitude; internal/external demand and high decision latitude; weak pace constraints and high decision latitude. Relationships with MSD diagnosed by occupational physicians were then studied.
The specific health programs (SHP) are one of the four mechanisms of prevention planned by the Health and Safety at work Law in the province of Quebec. If the Law appoints only a responsible doctor, it is in reality Health at work teams (HWT) that develop these SHP. In this communication, based on the model of the working situation and the diagram of inter professional practices of collaboration, we study the practices of inter professional collaboration (CIP) in the HWT. The observed practices vary between independent practices, in parallel, of consultation, of dialogue and in shared services. Formalization of the teams, coordination of communication, leadership, respect and professional identities influence particularly the practices of CIP.
L’objectif était d’identifier des patterns de caractéristiques d'organisation du travail à partir des données du programme de surveillance épidémiologique des troubles musculo-squelettiques (TMS) mis en œuvre dans les Pays de la Loire entre 2002 et 2005. Au total, 3 710 salariés ont été inclus et ont répondu à un questionnaire comportant notamment 16 variables organisationnelles. Une classification ascendante hiérarchique (CAH) des variables organisationnelles puis une CAH des salariés ont permis d’identifier cinq patterns de caractéristiques d’organisation du travail : contraintes techniques et faible latitude décisionnelle ; demande interne/externe et latitude décisionnelle moyenne ; faibles contraintes de rythme et latitude décisionnelle moyenne ; demande externe/interne et forte latitude décisionnelle ; faibles contraintes de rythme et forte latitude décisionnelle. Les associations avec les TMS diagnostiqués par des médecins du travail ont ensuite été étudiées.
Actes du 50ème congrès de la Société d'Ergonomie de Langue Française
Paris, France

halshs-01307785
https://halshs.archives-ouvertes.fr/halshs-01307785

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : International audience
We provide new constraints on the modes of mantle exhumation and denudation in the pre-orogenic Pyrenees by investigating the poorly known peridotites located east of the Lherz body, in eastern Ariè ge (Vicdessos, Urs, Bestiac, Caussou and Prades main peridotitic bodies). We show that: (1) numerous peridotite bodies, not described so far, are constituted by decametric to sub-metric outcrops scattered between and around the main outcrops identified by Monchoux (1970); (2) most of the peridotites form blocks and lenses of various sizes, from millimetric monocrystalline grains to hectometric olistoliths, embedded in debris flows involving mainly Mesozoic metasediments; these peridotites can therefore be linked to the S-type peridotites of Lagabrielle et al. (2010), and share similarities with the peridotites of Lherz region (Clerc et al., 2012). All originated from tectono-sedimentary processes associated with mantle exhumation in relation with extreme thinning and breakoff of the continental basement; (3) the various petrographic characters of these peridotites and their heterogeneity in serpentinisation degree imply a peculiar mode of exhumation, which merges mantle fragments inherited from different structural levels; (4) the lack of tectonic structures such as faults and shear planes associated with the ultramafic-rich breccia formation and the presence of neoformation of metamorphic minerals within the matrix preclude their origin as cataclasites related to the Latest Cretaceous and Tertiary Pyrenean contractional deformation. The peridotites of eastern Ariè ge are indisputable witnesses of the presence of an inverted hyper-extended Cretaceous passive margin forming the current North Pyrenean zone. The geometry of the extensional system was complex and probably associated with strike-slip faults and transcurrent motion. ß 2016 The Authors. Published by Elsevier Masson SAS on behalf of Acadé mie des sciences. This is an open access article under the CC BY-NC-ND license (http://creativecommons. org/licenses/by-nc-nd/4.0/).
ISSN: 1631-0713

Droits : http://creativecommons.org/licenses/by-nc-nd/
insu-01280502
https://hal-insu.archives-ouvertes.fr/insu-01280502
https://hal-insu.archives-ouvertes.fr/insu-01280502/document
https://hal-insu.archives-ouvertes.fr/insu-01280502/file/1-s2.0-S1631071316000043-main.pdf
DOI : 10.1016/j.crte.2015.12.003

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : 14 pages
International audience
Central Africa hosts the world's second largest tropical forest after the Amazonian basin. However, as compared to its Amazonian counterpart, the Central Africa forests receive much less rain (∼1500 mm/year in mean spread over two rainy seasons in March-May and September-November, and two dry seasons). They also experience a slower deforestation rate, so that the main threat for the next decades might come from climate variations. Nonetheless, their response to the annual cycle of solar radiation and rainfall/clouds is still poorly known. Analysing high resolution remote sensing data of Enhanced Vegetation Index, rainfall, cloudiness, and solar radiation for a target region located between 0 and 5°N and 12–19°E, we explore the climatic drivers of the forests greenness mean annual cycle. Three main points emerge; first, the diurnal cycle is a key-scale for understanding the mean annual cycles of rainfall and incoming solar radiation at surface, then how climate shapes the greenness mean annual evolution; second, neither the two dry seasons nor the two rainy seasons resemble each other in terms of cloud cover, solar radiation and rainfall, and their links with greenness levels; third, whereas the first rainy season (March-May) appears optimal for greenness especially because of favorable light conditions, water availability is the main controlling factor during the main dry season and at the start of the first vegetative season (February). Regarding the little dry season (mid-June-mid-August) and the second rainy season (September-October), light availability might be the main limiting factor. These findings pave the way for further studies of the climate interannual variability and change impacts on the Central Africa forests, taking into account time-scale interactions.
ISSN: 0168-1923

hal-01309565
https://hal.archives-ouvertes.fr/hal-01309565
DOI : 10.1016/j.agrformet.2016.04.005

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Past studies have shown that high coastal uplift rates are restricted to active areas, especially in a subduction context. The origin of coastal uplift in subduction zones, however, has not yet been globally investigated. Quaternary shorelines correlated to the last interglacial maximum (MIS 5e) were defined as a global tectonic benchmark (Pedoja et al. (2011)). In order to investigate the relationships between the vertical motion and the subduction dynamic parameters, we cross-linked this coastal uplift database with the "geodynamical" databases from Heuret (2005), Conrad and Husson (2009) and Müller et al. (2008). Our statistical study shows that: [1] the most intuitive parameters one can think responsible for coastal uplift (e.g., subduction obliquity, trench motion, oceanic crust age, interplate friction and force, convergence variation, dynamic topography, overriding and subducted plate velocity) are not related with the uplift (and its magnitude); [2] the only intuitive parameter is the distance to the trench which shows in specific areas a decrease from the trench up to a distance of ~300 km; [3] the slab dip (especially the deep slab dip), the position along the trench and the overriding plate tectonic regime are correlated with the coastal uplift, probably reflecting transient changes in subduction parameters. Finally we conclude that the first order parameter explaining coastal uplift is small-scale heterogeneities of the subducting plate, as for instance subducting aseismic ridges. The influence of large-scale geodynamic setting of subduction zones is secondary.
ISSN: 0264-3707

hal-00968538
https://hal.archives-ouvertes.fr/hal-00968538
https://hal.archives-ouvertes.fr/hal-00968538/document
https://hal.archives-ouvertes.fr/hal-00968538/file/henryterraces_v2.pdf
DOI : 10.1016/j.jog.2014.04.001

Éditeur(s) : HAL CCSD Elsevier
Résumé : DNA metabarcoding on soil samples is increasingly used for large-scale and multi-taxa biodiversity studies. However, DNA extraction may be a major bottleneck for such wide uses. It should be cost/time effective and allow dealing with large sample volumes so as to maximise the representativeness of both micro- and macro-organisms diversity. Here, we compared the performances of a fast and cheap extracellular DNA extraction protocol with a total DNA extraction method in retrieving bacterial, eukaryotic and plant diversity from tropical soil samples of ca. 10 g. The total DNA extraction protocol yielded more high-quality DNA. Yet, the extracellular DNA protocol provided similar diversity assessments although it presented some differences in clades relative abundance and undersampling biases. We argue that extracellular DNA is a good compromise between cost, labor, and accuracy for high throughput DNA metabarcoding studies of soil biodiversity.
ISSN: 0038-0717

hal-01532638
https://hal.archives-ouvertes.fr/hal-01532638
DOI : 10.1016/j.soilbio.2016.01.008
PRODINRA : 384522

Éditeur(s) : HAL CCSD
Résumé : National audience
Epidemiological researches in the field of DOHaD are in favor of a role of early environment, including chemical (pesticides), physical (air pollution), nutritional or psychosocial environment, on child and adult health. Disentangling the different factors of environment that may affect health, especially over time, and identifying critical periods of exposure remains a major challenge. The biological mechanisms involved remain elusive in human beings. Nevertheless, it seems that whatever the nature of the exposure, epigenetic mechanisms are currently discussed to explain how the environment may alter biological systems over time.
Les résultats épidémiologiques dans le domaine de la DOHaD (developmental origins of health and disease) sont en faveur d’un rôle de l’environnement précoce sur la santé immédiate mais aussi future, qu’il s’agisse de l’environnement physique, chimique, nutritionnel ou encore psychosocial. Faire la part des différents facteurs de l’environnement susceptibles de modifier la santé, notamment sur le long terme, et des périodes critiques d’exposition reste un enjeu majeur. De même, les multiples mécanismes biologiques impliqués restent encore, pour une grande part, à identifier chez l’homme. Il semble néanmoins que, quelle que soit la nature de l’exposition considérée, des mécanismes épigénétiques sont actuellement évoqués pour expliquer comment l’environnement est susceptible de modifier des systèmes biologiques sur le long terme.
Médecine Sciences: M/S

hal-01274219
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01274219
DOI : 10.1051/medsci/20163201005
PUBMED : 26850603

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
Iran is an active continental domain accommodating the convergence between the Arabia and Eurasia plates. In northwestern Iran, deformation between the Central Iranian block and the Caucasus domain is mainly accommodated by right lateral strike-slip on the Tabriz fault. Cities and villages, including the city of Tabriz, have been destroyed by several strong historical earthquakes (M similar to 7). In this study, we compare the slip-rates estimated from geodetic measurements (radar interferometry and UPS) with those determined by dating a geomorphological offset of an alluvial fan along the Tabriz fault. The GPS measurements along two profiles normal to the Tabriz fault suggest a slip-rate of 7.3 +/- 1.3 mm yr(-1). The persistent scatterer radar interferometry analysis of Envisat satellite archives from 2003 to 2010 shows a velocity gradient (6 +/- 3 mm yr(-1)) across the Tabriz fault in agreement with GPS results. Moreover, it reveals that most of the area located south of the Tabriz fault is affected by subsidence, and that some sections of the fault probably act as barriers to fluid migration which may have an impact on its mechanical behaviour. West of Tabriz morphotectonic investigations on an alluvial fan surface show a right-lateral cumulative offset of 320 +/- 40 m Luminescence analyses of the coarse matrix alluvial fan deposits provide an age of 46 +/- 3 ka. This yields a slip-rate comprised between 6.5 and 7.3 mm yr(-1) along this segment. These results suggest that the Late Quaternary slip-rate is in agreement with the present-day slip-rate estimated by geodetic measurements, showing no slip-rate changes during the past 45 000 yr. Short-term variations within the 45 000 yr related to temporal earthquake clustering over few seismic cycles cannot be ruled out, but if they exist, they do not affect the geodetic and the geomorphological estimates. This study is in agreement with previous ones suggesting that long-term slip-rates (i.e. averaged over several tens of seismic cycles) are consistent with geodetic estimated slip-rates (i.e. extrapolated from few years of interseismic observations), and suggests that perturbations of fault slip-rates are related to variations over few seismic cycles.
ISSN: 0956-540X

hal-00844695
https://hal.archives-ouvertes.fr/hal-00844695
https://hal.archives-ouvertes.fr/hal-00844695v2/document
https://hal.archives-ouvertes.fr/hal-00844695/file/rizza2013.pdf
DOI : 10.1093/gji/ggt041

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
Bone Morphogenetic Protein 9 (BMP9) has been recently found to be the physiological ligand for the activin receptor-like kinase 1 (ALK1), and to be a major circulating vascular quiescence factor. Moreover, a soluble chimeric ALK1 protein (ALK1-Fc) has recently been developed and showed powerful anti-tumor growth and anti-angiogenic effects. However, not much is known concerning BMP9. This prompted us to investigate the human endogenous sources of this cytokine and to further characterize its circulating form(s) and its function. Analysis of BMP9 expression reveals that BMP9 is produced by hepatocytes and intrahepatic biliary epithelial cells. Gel filtration analysis combined with ELISA and biological assays demonstrate that BMP9 circulates in plasma (1) as an unprocessed inactive form that can be further activated by furin a serine endoprotease, and (2) as a mature and fully active form (composed of the mature form associated with its prodomain). Analysis of BMP9 circulating levels during mouse development demonstrates that BMP9 peaks during the first 3 weeks after birth and then decreases to 2 ng/mL in adulthood. We also show that circulating BMP9 physiologically induces a constitutive Smad1/5/8 phosphorylation in endothelial cells. Taken together, our results argue for the role of BMP9 as a hepatocyte-derived factor, circulating in inactive (40%) and active (60%) forms, the latter constantly activating endothelial cells to maintain them in a resting state.
ISSN: 1420-682X

hal-00681969
https://hal.archives-ouvertes.fr/hal-00681969
DOI : 10.1007/s00018-011-0751-1
PUBMED : 21710321

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The Demerara plateau, located offshore French Guiana and Suriname, is part of a passive transform continental margin particularly prone to develop slope instabilities, probably in relation to the presence of a free distal border along its steep continental slope. Slope failure occurred at different periods (Cretaceous to Neogene) and shows an overall retrogressive evolution through time. Upslope these failure headscarp, an enigmatic regional Mio-Pliocene unconformity has been discovered through the interpretation of new academic and industrial datasets. The aim of this work is to describe and understand the origin of this surface. Our analysis shows that this unconformity is made of a series of valleys that cross-cut sedimentary strata. Each one of these valleys has a short lateral extent and is closed along two perpendicular directions, which suggests that it could correspond to a highly meandering system, or to some sub-circular depressions. The infill of these features is equivalent to the regional stratigraphic strata found outside the structures, but in a subdued position. This seems to imply that the structures have originated by a local loss of sediments at their base or by sliding processes. Furthermore, these depressions intersect each other through time, while migrating progressively downslope.We discuss a series of hypotheses that try to explain the onset and evolution of these depressions forming the Mio-Pliocene unconformity (Canyons? Slope failures? Contourite moats? Hydrate pockmarks?). Having established that these structures are depressions formed by collapse, and have many similarities with structures recently described in the literature as pockmarks associated with gas hydrate dissolution, we favor this hypothesis.We propose that these hydrate pockmarks form with a mass failure that was triggered by fluid-overpressure development at the base of the hydrate stability zone.
ISSN: 0025-3227

hal-01365920
https://hal.archives-ouvertes.fr/hal-01365920
DOI : 10.1016/j.margeo.2015.04.001

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
Varicella zoster virus (VZV) is a leading cause of acute viral encephalitis but little is known about its clinical, biological and imaging features. Furthermore, the most favourable treatment regimen has not been determined. We studied a prospective cohort of 20 HIV-negative patients presenting with acute VZV encephalitis caused by primary infection or reactivation. VZV was identified in 16 of 20 cases by PCR detection of the DNA in the cerebrospinal fluid. The four remaining cases occurred during or soon after a VZV rash. The median age of the 17 adults was 76 (19-86) years; the three other patients were children (0.5-5 years). Three patients were immunocompromised. Nine adult patients presented with a rash. Eighteen patients presented with fever and an acute encephalitic syndrome: diffuse brain dysfunction, focal neurological signs, seizures and cranial nerve palsies. Three patients presented with either ventricular or subdural haemorrhage, one with myelitis, and one with asymptomatic stenosis of the middle cerebral artery. The imaging was either normal or revealed non-specific abnormalities such as cortical atrophy but no evidence of stroke. All patients were given acyclovir at various dosages and durations but the case fatality rate remained high (15%) and sequelae were frequently observed either at discharge or at follow-up 3 years later.
ISSN: 1198-743X

hal-00875232
https://hal.archives-ouvertes.fr/hal-00875232
PUBMED : 22085160
DOI : 10.1111/j.1469-0691.2011.03705.x

Éditeur(s) : HAL CCSD
Résumé : International audience
Metamorphic soles correspond to m to 500m thick tectonic slices welded beneath most of the large-scale ophiolites.They typically show a steep inverted metamorphic structure where the pressure and temperature conditions ofcrystallization increase upward (from 500100ºC at 0.50.2 GPa to 800100ºC at 1.00.2 GPa), with isogradssubparallel to the contact with the overlying ophiolitic peridotite. The proportion of mafic rocks in metamorphicsoles also increases from the bottom (meta-sediments rich) to the top (approaching the ophiolite peridotites). Thesesoles are interpreted as the result of heat transfer from the incipient mantle wedge toward the nascent slab (associatedwith large-scale fluid transfer and possible shear heating) during the first My of intra-oceanic subduction(as indicated by radiometric ages). Metamorphic soles provide therefore major constraints on early subductiondynamics (i.e. thermal structure, fluid migration and rheology along the nascent slab interface).We present a detailed structural and petrological study of the metamorphic sole from 4 major cross-sections alongthe Oman ophiolite. We show precise pressure–temperature estimates obtained by pseudosection modelling andEBSD measurements performed on both the garnet-bearing and garnet-free high-grade sole. Results allow quantificationof the micro-scale deformation and highlight differences in pressure–temperature–deformation conditionsbetween the 4 different locations, showing that the inverted metamorphic gradient through the sole is not continuousin all locations.Based on these new constraints, we suggest a new tectonic–petrological model for the formation of metamorphicsoles below ophiolites. This model involves the stacking of several homogeneous slivers of oceanic crust leadingto the present-day structure of the sole. In this view, these thrusts are the result of rheological contrasts between thesole and the peridotite as the plate interface progressively cools down. These slivers later underwent several stagesof retrogression (partly mediated by ascending fluids from the slab) from amphibolite- to prehnite/pumpellite-faciesconditions.
Geophysical Research Abstracts
Vienne, Austria

insu-01309369
https://hal-insu.archives-ouvertes.fr/insu-01309369

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
Most kimberlites contain abundant dunitic nodules. These are centimetre-sized, rounded and multi-grained assemblages of xenocrystic olivine with a wide range of compositions (Fo83 to Fo94). The absence of orthopyroxene and other mantle minerals and the range of olivine compositions have been attributed to reaction between mantle peridotite and (proto)kimberlitic fluid or melt, but the timing of the reaction is a subject of debate. In a kimberlite from the Kangamiut region of Greenland, nodule cores are surrounded by fine-grained outer margins with near-constant Fo contents (∼Fo88) but highly variable minor element contents (e.g. 500–2500 ppm Ni). These margins crystallized from the kimberlite melt and we show that their compositions can be explained by crystallization of olivine alone, if a high partition coefficient for Ni between melt and olivine (DNi > 20) is assumed. Orthopyroxene assimilation is not required, removing the constraint that its dissolution occurred during ascent of the kimberlite magma. Within some nodules, in addition to the usual core-to-margin gradients, we observe asymmetric compositional changes (variable Fo but near-constant minor element contents) across mobile grain boundaries. These changes document fluid percolation at the grain scale that occurred during dynamic recrystallization in the deforming lithospheric mantle. We note that chemical gradients associated with mobile grain boundaries are observed in olivines that cover the entire compositional range of the nodules, and propose that fluid-assisted dynamic recrystallization took place in dunite that was already compositionally heterogeneous. Reaction between peridotite and protokimberlitic melt or fluid and dissolution of orthopyroxene thus occurred within the lithospheric mantle, immediately (a few days) prior to the ascent of the kimberlite melt and the entrainment of the dunite nodules. We propose that the grain boundary zones probably mimic, at a fine scale, the fluid–peridotite interaction that caused, at a larger scale, orthopyroxene dissolution and formation of compositionally diverse olivine in kimberlites.
ISSN: 0022-3530

hal-01277963
https://hal.archives-ouvertes.fr/hal-01277963
DOI : 10.1093/petrology/egv054

Éditeur(s) : HAL CCSD Nature Publishing Group
Résumé : International audience
Androgen signaling, via the androgen receptor (AR), is crucial in mediating prostate cancer (PCa) initiation and progression. Identifying new downstream effectors of the androgens/AR pathway will allow a better understanding of these mechanisms and could reveal novel biomarkers and/or therapeutic agents to improve the rate of patient survival. We compared the microRNA expression profiles in androgen-sensitive LNCaP cells stimulated or not with 1 nM R1881 by performing a high-throughput reverse transcriptase-quantitative PCR and found that miR-135a was upregulated. After androgen stimulation, we showed that AR directly activates the transcription of miR-135a2 gene by binding to an androgen response element in the promoter region. Our findings identify miR-135a as a novel effector in androgens/AR signaling. Using xenograft experiments in chick embryos and adult male mice, we showed that miR-135a overexpression decreases in vivo invasion abilities of prostate PC-3 cells. Through in vitro wound-healing migration and invasion assays, we demonstrated that this effect is mediated through downregulating ROCK1 and ROCK2 expression, two genes that we characterized as miR-135a direct target genes. In human surgical samples from prostatectomy, we observed that miR-135a expression was lower in tumoral compared with paired adjacent normal tissues, mainly in tumors classified with a high Gleason score (⩾8). Moreover, miR-135a expression is lower in invasive tumors, showing extraprostatic extension, as compared with intraprostatic localized tumors. In tumor relative to normal glands, we also showed a more frequently higher ROCK1 protein expression determined using a semi-quantitative immunohistochemistry analysis. Therefore, in tumor cells, the lower miR-135a expression could lead to a higher ROCK1 protein expression, which could explain their invasion abilities. The highlighted relationship between miR-135a expression level and the degree of disease aggressiveness suggests that miR-135a may be considered as a prognostic marker in human PCa.Oncogene advance online publication, 28 July 2014; doi:10.1038/onc.2014.222.
ISSN: 0950-9232

hal-01063902
https://hal.archives-ouvertes.fr/hal-01063902
https://hal.archives-ouvertes.fr/hal-01063902/file/Androgen-regulated%20microRNA-135a.pdf
DOI : 10.1038/onc.2014.222
PUBMED : 25065599

Éditeur(s) : HAL CCSD
Résumé : International audience
The development of transport infrastructures lead to increase the exposure of population to high noise levels. The objective of this work is to define an indicator representative of the health risk induced by noise pollution in urban environment and adapted to the geographical resolution of IRIS. The methodology for the definition of the indicator considers in a first part the health aspect with the health data for the following effects: annoyance, sleep disturbance and cardiovascular diseases. Then, in a second part, methodology considers some effects related to the urban context since the configuration of urban space can change the exposure of population to noise and the perception of noise. The work is achieved with a GIS software and the input acoustical data comes from noise maps calculated for the END. The indicator seems to be relevant and interesting as it brings health information.
InterNoise 2010 Noise and Sustainability
Lisbonne, Portugal

halshs-00664636
https://halshs.archives-ouvertes.fr/halshs-00664636