Éditeur(s) : HAL CCSD American Geophysical Union (AGU)
Résumé : International audience
The present-day topography of the Tian Shan range is considered to result from crustal shortening related to the ongoing India-Asia collision that started in the early Tertiary. In this study we report evidence for several episodes of localized tectonic activity which occurred prior to that major orogenic event. Apatite fission track analysis and (U-Th)/He dating on apatite and zircon indicate that inherited Paleozoic structures were reactivated in the late Paleozoic-early Mesozoic during a Cimmerian orogenic episode and also in the Late Cretaceous-Paleogene (around 65-60 Ma). These reactivations could have resulted from the accretion of the Kohistan-Dras arc or lithospheric extension in the Siberia-Mongolia zone. Activity resumed in the late Mesozoic prior to the major Tertiary orogenic phase. Finally, the ongoing deformation, which again reactivates inherited tectonic structures, tends to propagate inside the endoreic basins that were preserved in the range, leading to their progressive closure. This study demonstrates the importance of inherited structures in localizing the first increments of the deformation before it propagates into yet undeformed areas.
ISSN: 0278-7407

Droits : info:eu-repo/semantics/OpenAccess
hal-00551323
https://hal.archives-ouvertes.fr/hal-00551323
https://hal.archives-ouvertes.fr/hal-00551323/document
https://hal.archives-ouvertes.fr/hal-00551323/file/2010TC002712.pdf
DOI : 10.1029/2010TC002712

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The present study aims to apply the AMS method (Anisotropy of Magnetic Susceptibility) at a regional scale to track the fluid circulation direction that has produced an iron metasomatism within pre-existing dolomite host rock. The Urgonian formations hosting the Zn-Pb mineralizations in La Florida (Cantabria, northern Spain) have been taken as target for this purpose. Sampling was carried out, in addition to ferroan dolomite host rock enclosing the Zn-Pb mineralizations, in dolomite host rock and limestone to make the comparison possible between magnetic signals from mineralized rocks, where fluid circulation occurred, and their surrounding formations. AMS study was coupled with petrofabric analysis carried out by texture goniometry, Scanning Electron Microscopy (SEM) observations and also Shape Preferred Orientation (SPO) statistics. SEM observations of ferroan dolomite host rock illustrate both bright and dark grey ribbons corresponding respectively to Fe enriched and pure dolomites. SPO statistics applied on four images from ferroan dolomite host rock give a well defined orientation of ribbons related to the intermediate axis of magnetic susceptibility K2. For AMS data, two magnetic fabrics are observed. The first one is observed in ferroan dolomite host rock and characterised by a prolate ellipsoid of magnetic susceptibility with a vertical magnetic lineation. The magnetic susceptibility carrier is Fe-rich dolomite. These features are probably acquired during metasomatic fluid circulations. In Fe-rich dolomite host rock, ‹c› axes are vertical. As a rule, (0001) planes (i.e. planes perpendicular to ‹c› axes) are isotropic with respect to crystallographic properties. So, the magnetic anisotropy measured in this plane should reflect crystallographic modification due to fluid circulation. This is confirmed by the texture observed using the SEM. Consequently, AMS results show a dominant NE-SW elongation interpreted as the global circulation direction and a NW-SE secondary elongation that we have considered as sinuosities of the fluid trajectory. The second type of magnetic fabric is essentially observed in the limestone and characterised by an oblate form of the ellipsoid of magnetic susceptibility, a horizontal magnetic foliation and mixed magnetic susceptibility carriers. It is interpreted as a sedimentary fabric.
ISSN: 0012-821X

insu-00342499
https://hal-insu.archives-ouvertes.fr/insu-00342499
https://hal-insu.archives-ouvertes.fr/insu-00342499/document
https://hal-insu.archives-ouvertes.fr/insu-00342499/file/Essalhi-EPSL-2008.pdf
DOI : 10.1016/j.epsl.2008.11.011

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Mammalian spermatogenesis, which takes place in complex testicular structures called seminiferous tubules, is a highly specialized process controlled by the integration of juxtacrine, paracrine and endocrine information. Within the seminiferous tubules, the germ cells and Sertoli cells are surrounded by testicular fluid (TF), which probably contains most of the secreted proteins involved in crosstalk between these cells. It has already been established that germ cells can modulate somatic Sertoli cell function through the secretion of diffusible factors. We studied the germ cell secretome, which was previously considered inaccessible, by analyzing the TF collected by microsurgery in an "integrative omics" strategy combining proteomics, transcriptomics, genomics and interactomics data. This approach identified a set of proteins preferentially secreted by Sertoli cells or germ cells. An interaction network analysis revealed complex, interlaced cell-cell dialog between the secretome and membranome of seminiferous cells, mediated via the TF. We then focused on germ cell-secreted candidate proteins, and we identified several potential interacting partners located on the surface of Sertoli cells. Two interactions, APOH/CDC42 and APP/NGFR, were validated in situ, in a proximity ligation assay (PLA). Our results provide new insight into the crosstalk between germ cells and Sertoli cells occurring during spermatogenesis. Our findings also demonstrate that this "integrative omics" strategy is powerful enough for data mining and highlighting meaningful cell-cell communication events between different types of cells in a complex tissue, via a biological fluid. This integrative strategy could be applied more widely, to gain access to secretomes that have proved difficult to study whilst avoiding the limitations of in vitro culture.
ISSN: 1932-6203

hal-01129957
https://hal.archives-ouvertes.fr/hal-01129957
https://hal.archives-ouvertes.fr/hal-01129957/document
https://hal.archives-ouvertes.fr/hal-01129957/file/2014_FChalmel_PlosOne_%7B1236BFCE-4830-400D-B816-4B6651311900%7D.pdf
DOI : 10.1371/journal.pone.0104418

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
In this contribution we present a reconstruction of the overall lithotectonic architecture, from inner zones to external ones, of the Paleoproterozoic Trans North China Orogen, within the North China Craton. Moreover, forward thermobarometrical modeling on a kyanite-bearing gneiss yields a reliable prograde P-T-t-D path. In addition, 40Ar/39Ar dating on rocks from distinct litho-tectonic units helps us to distinguish several tectono-metamorphic events during the orogenic development. Considering these results, we propose a geodynamic model involving three cratonic blocks, namely the Western, Fuping and Eastern Blocks, separated by two oceans, the Lüliang and Taihang Oceans. The opening of oceanic basins occurred around 2.2-2.3 Ga. After the westward subductions of oceanic lithosphere, the Trans-North-China Orogen was built up through a polyphase tectonic evolution within the period 1900-1800 Ma. The first event (D1) corresponded to the emplacement of lower and upper nappes herein called the Orthogneiss-and-Volcanites Unit (OVU) and the Low-Grade-and-Mafic Unit (LGMU), respectively. The syn-metamorphic D1 deformation (1880 ± 10 Ma) is characterized by a NW-SE stretching and mineral lineation with a top-to-the SE sense of shear. During ongoing compression of the thickening orogenic crust, a second deformation event D2 (1850 ± 10 Ma) was responsible for (1) syn-anatectic lateral flow and exhumation of the orogenic root and (2) folding of the middle and upper parts of the orogenic wedge that consequently acquired a fan-type geometry. The late D3 (1830 ± 10 Ma) and D4 (1810 ± 10 Ma) events are related to late-orogenic normal and strike-slip shearing, respectively. In our present state of knowledge, the Paleoproterozoic Trans-North China Orogen might be regarded as the assemblage of two continent-continent collisional belts, both of which are characterized by nappe stacking accommodated by top-to-the E/SE ductile shearing. Continental subduction, crustal thickening, partial melting of overthickened crust, exhumation of HP rocks and deposition of syn-orogenic detrital basins are typical features of modern collisional-type orogens.
ISSN: 0301-9268

Droits : info:eu-repo/semantics/OpenAccess
insu-00628119
https://hal-insu.archives-ouvertes.fr/insu-00628119
https://hal-insu.archives-ouvertes.fr/insu-00628119/document
https://hal-insu.archives-ouvertes.fr/insu-00628119/file/Trap-PrecambrianResearch-2011.pdf
DOI : 10.1016/j.precamres.2011.09.008

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
ISSN: 0944-1344

hal-01344742
https://hal.archives-ouvertes.fr/hal-01344742
DOI : 10.1007/s11356-016-7141-z

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Mechanism and kinematics of the Late Mesozoic continental extension event of eastern Asia are still debated. In order to better constrain its evolution, two granodioritic plutons of the Jiaodong Peninsula have been chosen as targets for a time-constrained palaeomagnetic study. Indeed, plutons are devoid of visible deformation, did not experience rotation along horizontal axis and are precisely dated by U/Pb and 40Ar/39Ar methods. Multidomain (MD) magnetite has been identified as the principal magnetic remanent carrier. The interpolation of existing and new U/Pb and 40Ar/39Ar ages revealed that characteristic remanent magnetisation was acquired in a narrow range of 116 ± 2 Ma. Twenty out of 27 sites present stable magnetic directions calculated from high-temperature or high-coercive components. The observations of the solo normal magnetic polarity for this palaeomagnetic collection and of the magnetic remanent age consistent with the Cretaceous Normal Superchron (CNS) argue that the characteristic magnetic remanence may be considered as primary. Detailed field observations of the intrusive relationship between the plutons and country rocks and Anisotropy of Magnetic Susceptibility (AMS) study reveal the absence of the subsequent deformation of plutons, or rigid rotation of plutons along a horizontal axis. Two palaeomagnetic poles have been therefore calculated from these plutons. Among 12 out 15 Cretaceous palaeomagnetic poles, including the two new poles provided by this study, from the Jiaodong Peninsula and on both sides of Tan-Lu and Muping-Jimo faults are statistically consistent. As a result, the Jiaodong Peninsula behaved as a rigid block as internal deformation appears negligible. The remaining three derived poles are probably due to the secular variation or/and the vicinity of fault zones near of the palaeomagnetic sampling site. Thus, they can not be applied to the peninsula-scaled tectonics. Comparison of these time52 constrained Cretaceous palaeomagnetic results of the Jiaodong Peninsula with those of North China Block (NCB) indicate that the Jiaodong Peninsula was rigidly attached to NCB since, 3 at least, the Cretaceous as residual difference is clearly insignificant with respect to the error brackets. These new palaeomagnetic results confirm that the relative clockwise (CW) rotation of Eastern Liaoning-Korea Block (ELKB) with respect to NCB does not affect the Jiaodong Peninsula as a rigid block, nevertheless, some tectonic structures have been reactivated since Cenozoic and local rotations could be produced. This palaeomagnetic study reveals that the Late Mesozoic extension in Eastern Asia is heterogeneously expressed in time and space. The complete understanding of the mechanism(s) of this extensional event needs further multidisciplinary investigations.
ISSN: 0031-9201

insu-00599546
https://hal-insu.archives-ouvertes.fr/insu-00599546
https://hal-insu.archives-ouvertes.fr/insu-00599546/document
https://hal-insu.archives-ouvertes.fr/insu-00599546/file/Charles_et_al_PEPI2011.pdf
DOI : 10.1016/j.pepi.2011.05.006

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Growth charts are an essential clinical tool for evaluating a child's health and development. The current French reference curves, published in 1979, have recently been challenged by the 2006 World Health Organization (WHO) growth charts. To evaluate and compare the growth of French children who were born between 1981 and 2007, with the WHO growth charts and the French reference curves currently used. Anthropometric measurements from French children, who participated in 12 studies, were analyzed: 82,151 measurements were available for 27,257 children in different age groups, from birth to 18 years. We calculated and graphically compared mean z-scores based on the WHO and French curves, for height, weight and Body Mass Index (BMI) according to age and sex. The prevalence of overweight using the WHO, the French and International Obesity Task Force definitions were compared. Our population of children was on average 0.5 standard deviations taller than the French reference population, from the first month of life until puberty age. Mean z-scores for height, weight and BMI were closer to zero based on the WHO growth charts than on the French references from infancy until late adolescence, except during the first six months. These differences not related to breastfeeding rates. As expected, the prevalence of overweight depended on the reference used, and differences varied according to age. The WHO growth charts may be appropriate for monitoring growth of French children, as the growth patterns in our large population of French children were closer to the WHO growth charts than to the French reference curves, from 6 months onwards. However, there were some limitations in the use of these WHO growth charts, and further investigation is needed.
ISSN: 1932-6203

hal-01134193
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01134193
DOI : 10.1371/journal.pone.0120806
PUBMED : 25761138
PUBMEDCENTRAL : PMC4356547

Éditeur(s) : HAL CCSD
Résumé : International audience
The host-parasite genera Proformica-Rossomyrmex present four pairs of species with a very wide range of distribution from China to Southeastern Spain, from huge extended plains to the top of high mountains. Here we review (1) the published data on these pairs in comparison to other slave-makers; (2) the different dispersal ability in hosts and parasites inferred from genetics (chance of migration conditions the evolutionary potential of the species); (3) the evolutionary potential of host and parasite determining the coevolutionary process in each host-parasite system that we treat to define using cuticular chemical data. We find a lower evolutionary potential in parasites than in hosts in fragmented populations, where selective pressures give advantage to a limited female parasite migration due to uncertainty of locating a host nest. A similar evolutionary potential is detected for hosts and parasites when the finding of host nests is likely (i.e., in continuous and extended populations). Moreover, some level of local adaptation at CHC profiles between host and parasite exists independently of the kind of geographic distribution and the ability of dispersal of the different populations. Similarity at CHC profiles appears to be a trait imposed by natural selection for the interaction between hosts and slave-makers.
Psyche

hal-01322574
https://hal.archives-ouvertes.fr/hal-01322574
DOI : 10.1155/2013/541804

Éditeur(s) : HAL CCSD Human Kinetics
Résumé : International audience
ISSN: 1063-8652

hal-01633114
https://hal.archives-ouvertes.fr/hal-01633114
https://hal.archives-ouvertes.fr/hal-01633114/document
https://hal.archives-ouvertes.fr/hal-01633114/file/Main%20document%20pour%20HAL.pdf
DOI : 10.1123/japa.2017-0069

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
Geochronological, mineralogical, and geochemical analyses have been focussed on the Mont-Loze're- Borne plutonic complex and surrounding rocks (Ce'vennes, French Massif Central) in which B-W-Sn and As-Au-Sb mineralization is encountered. Two main results are highlighted: (1) the existence of a 301-306 Ma magmatohydrothermal event unrelated to the emplacement of the Pont-de-Montvert-Borne plutonic body at 316 Ma; (2) the magmatic and hydrothermal features are strongly associated, both in time and in space, thus demonstrating an intimate connection between mineralizing processes and magmatism in this part of the French Massif Central. We also show that mineralization and associated hydrothermal occurrences do not correspond to a simple and single geochemical signature and that a contamination model must be invoked in order to account for the complexity of isotopic results. This study demonstrates that the application of the O and H isotopic signatures as tracers of the source and nature of fluids in an orogenic context requires some specific care. Finally, a model of the tectonic-magmatic- hydrothermal evolution of the study area is suggested in which we discuss two alternative scenarios. The first one implies the existence of two different hydrothermal/ mineralizing events (Bo-W-Sn and As-Au-Sb ones). The second one suggests the same source for all hydrothermal and mineralized structures.
ISSN: 1437-3254

insu-00576546
https://hal-insu.archives-ouvertes.fr/insu-00576546
https://hal-insu.archives-ouvertes.fr/insu-00576546/document
https://hal-insu.archives-ouvertes.fr/insu-00576546/file/Chauvet-InternationalJournalEarthSciences-2012.pdf
DOI : 10.1007/s00531-011-0639-1

Éditeur(s) : HAL CCSD
Résumé : International audience
Up-to-date estimates of the health outcomes of preterm children are needed for assessing perinatal care, informing parents, making decisions about care, and providing evidence for clinical guidelines. To determine survival and neonatal morbidity of infants born from 22 through 34 completed weeks' gestation in France in 2011 and compare these outcomes with a comparable cohort in 1997. The EPIPAGE-2 study is a national, prospective, population-based cohort study conducted in all maternity and neonatal units in France in 2011. A total of 2205 births (stillbirths and live births) and terminations of pregnancy at 22 through 26 weeks' gestation, 3257 at 27 through 31 weeks, and 1234 at 32 through 34 weeks were studied. Cohort data were collected from January 1 through December 31, 1997, and from March 28 through December 31, 2011. Analyses for 1997 were run for the entire year and then separately for April to December; the rates for survival and morbidities did not differ. Data are therefore presented for the whole year in 1997 and the 8-month and 6-month periods in 2011. Survival to discharge and survival without any of the following adverse outcomes: grade III or IV intraventricular hemorrhage, cystic periventricular leukomalacia, severe bronchopulmonary dysplasia, retinopathy of prematurity (stage 3 or higher), or necrotizing enterocolitis (stages 2-3). A total of 0.7% of infants born before 24 weeks' gestation survived to discharge: 31.2% of those born at 24 weeks, 59.1% at 25 weeks, and 75.3% at 26 weeks. Survival rates were 93.6% at 27 through 31 weeks and 98.9% at 32 through 34 weeks. Infants discharged home without severe neonatal morbidity represented 0% at 23 weeks, 11.6% at 24 weeks, 30.0% at 25 weeks, 47.5% at 26 weeks, 81.3% at 27 through 31 weeks, and 96.8% at 32 through 34 weeks. Compared with 1997, the proportion of infants surviving without severe morbidity in 2011 increased by 14.4% (P < .001) at 25 through 29 weeks and 6% (P < .001) at 30 through 31 weeks but did not change appreciably for those born at less than 25 weeks. The rates of antenatal corticosteroid use, induced preterm deliveries, cesarean deliveries, and surfactant use increased significantly in all gestational-age groups, except at 22 through 23 weeks. The substantial improvement in survival in France for newborns born at 25 through 31 weeks' gestation was accompanied by an important reduction in severe morbidity, but survival remained rare before 25 weeks. Although improvement in survival at extremely low gestational age may be possible, its effect on long-term outcomes requires further studies. The long-term results of the EPIPAGE-2 study will be informative in this regard.
ISSN: 2168-6211

hal-01258705
http://hal.univ-brest.fr/hal-01258705
PUBMED : 25621457
DOI : 10.1001/jamapediatrics.2014.3351

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Mammalian spermatogenesis, which takes place in complex testicular structures called seminiferous tubules, is a highly specialized process controlled by the integration of juxtacrine, paracrine and endocrine information. Within the seminiferous tubules, the germ cells and Sertoli cells are surrounded by testicular fluid (TF), which probably contains most of the secreted proteins involved in crosstalk between these cells. It has already been established that germ cells can modulate somatic Sertoli cell function through the secretion of diffusible factors. We studied the germ cell secretome, which was previously considered inaccessible, by analyzing the TF collected by microsurgery in an "integrative omics" strategy combining proteomics, transcriptomics, genomics and interactomics data. This approach identified a set of proteins preferentially secreted by Sertoli cells or germ cells. An interaction network analysis revealed complex, interlaced cell-cell dialog between the secretome and membranome of seminiferous cells, mediated via the TF. We then focused on germ cell-secreted candidate proteins, and we identified several potential interacting partners located on the surface of Sertoli cells. Two interactions, APOH/CDC42 and APP/NGFR, were validated in situ, in a proximity ligation assay (PLA). Our results provide new insight into the crosstalk between germ cells and Sertoli cells occurring during spermatogenesis. Our findings also demonstrate that this "integrative omics" strategy is powerful enough for data mining and highlighting meaningful cell-cell communication events between different types of cells in a complex tissue, via a biological fluid. This integrative strategy could be applied more widely, to gain access to secretomes that have proved difficult to study whilst avoiding the limitations of in vitro culture.
PLoS ONE

hal-01063901
https://hal.archives-ouvertes.fr/hal-01063901
DOI : 10.1371/journal.pone.0104418
PUBMED : 25111155

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
BACKGROUND: Mutations in the telomerase complex (TERT and TR) are associated with pulmonary fibrosis and frequent hematologic manifestations. The aim of this study was to characterize the prognosis of lung transplantation in patients with TERT or TR mutations. METHODS: Patients with documented TERT or TR mutations who received a lung transplant between 2007 and 2013 in France were identified via an exhaustive search of the lung transplantation network, one expert genetic laboratory, and the clinical research network on rare pulmonary diseases. RESULTS: There were 9 patients (7 men) with TERT (n = 6) or TR (n = 3) mutations who received a single (n = 8) or a double (n = 1) lung transplant for pulmonary fibrosis. Median age was 50 years (range, 35-61 years) at diagnosis and 52 years (range, 37-62 years) at the time of lung transplantation. Thrombocytopenia was present in 7 patients before lung transplantation. After lung transplantation, 6 patients developed myelodysplasia and/or bone marrow failure, directly contributing to death in 4 cases. Anemia was observed in 9 patients, and neutropenia was observed in 3 patients. The median survival after lung transplantation was 214 days (range, 59-1,709 days). CONCLUSIONS: Patients with mutations of the telomerase complex are at high risk of severe hematologic complications after lung transplantation, in particular, bone marrow failure. Specific recommendations should be developed for appropriate guidance regarding hematologic risk assessment before transplantation and management of the post-transplantation immunosuppressive regimen.
ISSN: 1053-2498

hal-01146848
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01146848
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01146848/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01146848/file/Severe%20hematological%20complications%20after%20lung%20transplantation_accepted.pdf
DOI : 10.1016/j.healun.2014.11.010

Éditeur(s) : HAL CCSD Springer Verlag (Germany)
Résumé : International audience
Environmental Science and Pollution Research

hal-01110873
https://hal.archives-ouvertes.fr/hal-01110873
DOI : 10.1007/s11356-014-3272-2

Éditeur(s) : HAL CCSD
Résumé : International audience
o abstract
Revue Des Maladies Respiratoires

hal-01647079
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01647079
DOI : 10.1016/j.rmr.2017.07.019
PUBMED : 28939154

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
This paper presents a reappraisal of the tectonic evolution of the Zanhuang Massif that lies at the eastern margin of the Trans-North China Orogen, a continent–continent collision belt that marked the amalgamation of the North China Craton in Late Paleoproterozoic. Detailed field work with focus on geometries of structures and kinematics was performed. This was completed with LA-ICP-MS U–Pb analyses on zircon, EPMA U–Th/Pb dating on monazite and 40Ar/39Ar dating on amphibole. These studies led us to propose a new three-fold litho-tectonic subdivision of the massif: The Western Zanhuang Domain (WZD) made of TTG, migmatite and pink anatectic granite is correlated to the Fuping Massif that crops out to the north-west. Both areas represent a continental block, called the Fuping Block, which acquired most of its architecture around 2100 Ma ago. The Eastern Zanhuang Domain (EZD) made of TTG and migmatite represents the western edge of an Eastern Neoarchean Block. In between, the Central Zanhuang Domain (CZD) is a NE–SW trending stack of supracrustal, gneiss and mafic magmatic rocks thrust sheets displaced toward the ESE upon the Eastern Block. The lithological features suggest that the CZD represents the remnant of an oceanic basin, called the Taihang Ocean that closed during the amalgamation of the Eastern Block and the Fuping Block around 1880–1850 Ma. In agreement with recent work done along the western margin of the belt, in the Lüliang Massif, this study documents the amalgamation of the North China Craton in response to the closure of two oceanic basins, namely the Lüliang Ocean and the Taihang Ocean. West-dipping subductions and collisions involving three distinct continental blocks, called the Western, the Fuping and the Eastern Blocks, took place around 1880–1850 Ma.
ISSN: 0301-9268

insu-00403871
https://hal-insu.archives-ouvertes.fr/insu-00403871
https://hal-insu.archives-ouvertes.fr/insu-00403871/document
https://hal-insu.archives-ouvertes.fr/insu-00403871/file/Trap-PrecambrianResearch-2009.pdf
DOI : 10.1016/j.precamres.2009.03.011

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Syn-orogenic detachments in accretionary wedges make the exhumation of high-pressure and low-temperature metamorphic rocks possible with little erosion. The velocity of exhumation within the subduction channel or the accretionary complex, and thus the shape of P-T paths, depend upon the kinematic boundary conditions. A component of slab retreat tends to open the channel and facilitates the exhumation. We document the effect of slab retreat on the shape of P-T paths using the example of the Phyllite-Quartzite Nappe that has been exhumed below the Cretan syn-orogenic detachment during the Miocene in Crete and the Peloponnese. Data show a clear tendency toward colder conditions at peak pressure and during exhumation where the intensity of slab retreat is larger. This spatial evolution of P-T gradient is accompanied with an evolution from a partly coaxial regime below the Peloponnese section of the detachment toward a clearly non-coaxial regime in Crete.
ISSN: 0040-1951

insu-00411771
https://hal-insu.archives-ouvertes.fr/insu-00411771
https://hal-insu.archives-ouvertes.fr/insu-00411771/document
https://hal-insu.archives-ouvertes.fr/insu-00411771/file/Jolivet-Tectonophysics-2010.pdf
DOI : 10.1016/j.tecto.2009.10.002

Éditeur(s) : HAL CCSD American Geophysical Union (AGU)
Résumé : International audience
The Tian Shan Mountains constitute central Asia's longest and highest mountain range. Understanding their Cenozoic uplift history thus bears on mountain building processes in general, and on how deformation has occurred under the influence of the India-Asia collision in particular. In order to help decipher the uplift history of the Tian Shan, we collected 970 samples for magnetostratigraphic analysis along a 4571-m-thick section at the Jingou River (Xinjiang Province, China). Stepwise alternating field and thermal demagnetization isolate a linear magnetization component that is interpreted as primary. From this component, a magnetostratigraphic column composed of 67 polarity chrons are correlated with the reference geomagnetic polarity timescale between ~1 Ma and ~23.6 Ma, with some uncertainty below ~21 Ma. This correlation places precise temporal control on the Neogene stratigraphy of the southern Junggar Basin and provides evidence for two significant stepwise increases in sediment accumulation rate at ~16–15 Ma and ~11–10 Ma. Rock magnetic parameters also undergo important changes at ~16–15 Ma and ~11–10 Ma that correlate with changes in sedimentary depositional environments. Together with previous work, we conclude that growth history of the modern Tian Shan Mountains includes two pulses of uplift and erosion at ~16–15 Ma and ~11–10 Ma. Middle to upper Tertiary rocks around the Tian Shan record very young (<~5 Ma) counterclockwise paleomagnetic rotations, on the order of 15° to 20°, which are interpreted as because of strain partitioning with a component of sinistral shear that localized rotations in the piedmont.
ISSN: 0278-7407

insu-00376345
https://hal-insu.archives-ouvertes.fr/insu-00376345
https://hal-insu.archives-ouvertes.fr/insu-00376345/document
https://hal-insu.archives-ouvertes.fr/insu-00376345/file/2007TC002137.pdf
DOI : 10.1029/2007TC002137

Éditeur(s) : HAL CCSD
Résumé : International audience
Objective To guide nosology and classification of patients with eosinophilic granulomatosis with polyangiitis (EGPA) based on phenotype and presence or absence of ANCA. Methods Organ manifestations and ANCA status were retrospectively analyzed based on the presence or not of predefined definite vasculitis features or surrogates of vasculitis in patients asthma, eosinophilia, and at least one systemic organ manifestation attributable to systemic disease. Results The study population included 157 patients (mean age 49.4 ± 14.1), with a follow-up of 7.4 ± 6.4 years. Patients with ANCA (31%) more frequently had weight loss, myalgias, arthralgias, biopsy-proven vasculitis, glomerulonephritis on biopsy, hematuria, leukocytoclastic capillaritis and/or eosinophilic infiltration of arterial wall on biopsy, and other renal disease. A total of 41% of patients had definite vasculitis manifestations (37%) or strong surrogates of vasculitis (4%), of whom only 53% had ANCA. Mononeuritis multiplex was associated with systemic vasculitis (p = 0.005) and with the presence of ANCA (p < 0.001). Overall, 59% of patients had polyangiitis as defined by definite vasculitis, strong surrogate of vasculitis, mononeuritis multiplex, and/or ANCA with at least one systemic manifestation other than ENT or respiratory. Patients with polyangiitis had more systemic manifestations including arthralgias (p = 0.02) and renal disease (p = 0.024), had higher peripheral eosinophilia (p = 0.027), and a trend towards less myocarditis (p = 0.057). Using predefined criteria of vasculitis and surrogates of vasculitis, ANCA alone were found to be insufficient to categorise patients with vasculitis features. Conclusion We suggest a revised nomenclature and definition for EGPA and a new proposed entity referred to as hypereosinophilic asthma with systemic (non vasculitic) manifestations. © 2016 Elsevier B.V.
Autoimmunity Reviews

hal-01467544
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01467544
DOI : 10.1016/j.autrev.2016.09.018
PUBMED : 27671089

Éditeur(s) : HAL CCSD
Résumé : International audience
Idiopathic pulmonary fibrosis (IPF) is the most frequent chronic idiopathic interstitial pneumonia in adults. The management of rare diseases in France has been organised by a national plan for rare diseases, which endorsed a network of expert centres for rare diseases throughout France. This article is an overview of the executive summary of the French guidelines for the management of IPF, an initiative that emanated from the French National Reference Centre and the Network of Regional Competence Centres for Rare Lung Diseases. This review aims at providing pulmonologists with a document that: 1) combines the current available evidence; 2) reviews practical modalities of diagnosis and management of IPF; and 3) is adapted to everyday medical practice. The French practical guidelines result from the combined efforts of a coordination committee, a writing committee and a multidisciplinary review panel, following recommendations from the Haute Autorité de Santé. All recommendations included in this article received at least 90% agreement by the reviewing panel. Herein, we summarise the main conclusions and practical recommendations of the French guidelines.
Eur Respir Rev

hal-01063982
https://hal.archives-ouvertes.fr/hal-01063982
DOI : 10.1183/09059180.00001814
PUBMED : 24881074