Éditeur(s) : HAL CCSD Landes Bioscience
Résumé : International audience
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
Autophagy

hal-00735751
https://hal.archives-ouvertes.fr/hal-00735751
PUBMED : 22966490

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Structural analysis along with 40Ar–39Ar and U–Pb datings in the Fuping massif provide new insight into the evolution of the eastern part of the Trans-North China Belt (North China Craton), from 2.7 Ga to 1.8 Ga. D1 is responsible for the development of a dome-and-basin structure coeval with crustal melting giving rise to migmatite and Nanying gneissic granites at 2.1 Ga. This dome-and-basin architecture resulted from the interference between a N–S compression of a weak ductile crust and gravity-driven vertical flow, in a high thermal regime. The next events involved flat lying ductile thrusting (D2) and normal faulting (D3) dated at around 1880 Ma and 1830 Ma, respectively. The D2 and D3 events belong to the Trans-North China Orogeny that results in the final amalgamation of the North China Craton. The D1 deformation is considered as evidence for an earlier orogen developed around 2.1 Ga prior to the Trans-North China Orogeny. The change in the deformation style between the 2.1 Ga and 1.8 Ga could be viewed as a consequence of the cooling of the continental crust in the North China Craton.
ISSN: 0191-8141

insu-00309553
https://hal-insu.archives-ouvertes.fr/insu-00309553
https://hal-insu.archives-ouvertes.fr/insu-00309553/document
https://hal-insu.archives-ouvertes.fr/insu-00309553/file/Trap-JStructuralGeology-2008.pdf
DOI : 10.1016/j.jsg.2008.05.001

Éditeur(s) : HAL CCSD Geological Society of London
Résumé : International audience
In Eastern China, the North China Block (NCB) has experienced a complex tectonic evolution during Late Palaeozoic to Mesozoic times. The unconformable sedimentary cover, which ranges in age from Neoproterozoic to Permian, underwent two tectonic episodes in Early Triassic and Cretaceous times. An early north–south compressional phase, D1, characterized by north-verging recumbent folds with east–west-trending axes and top-to-the-north ductile shear zones can be observed in a gabbroic pluton and the Neoproterozoic sedimentary host rocks. The available radiometric ages allow us to interpret this event as an Early Triassic back-thrusting related to the final stage of the collision between the North China and South China Blocks. During the LateMesozoic, an extensional event characterized by (1) half-grabens filled by continental terrigeneous red beds and lava flows, (2) low-angle detachment faults, (3) synkinematic granitic plutons, and (4) metamorphic core complexes is widespread in the Eastern Liaoning Peninsula. This extensional D2 event can be subdivided into a ductile deformation and a brittle deformation, corresponding to different expressions of crustal deformation. In every area studied in the Eastern Liaoning Peninsula, the ductile D2 deformation is characterized by a NW–SE-trending stretching lineation with a top-to-the-NWsense of shear.Mica and amphibole fromthe metamorphic country rocks, granodioritic or monzogranitic plutons and their mylonitized margins yield 40Ar/39Ar ages ranging from 130 to 120 Ma. These dates support fast cooling and exhumation rates coeval with the extensional tectonics. The brittle D2 deformation is responsible for the formation of high-angle normal faults marked by low-temperature cataclasites bounding half-grabens. During the Mesozoic, the tectonic regime of Eastern China experienced a significant inversion from compression to extension. The Eastern Liaoning Peninsula massif provides an example of this geodynamic transition.
ISSN: 2041-4927

hal-00134055
https://hal-insu.archives-ouvertes.fr/hal-00134055
DOI : 10.1144/SP280.7

Éditeur(s) : HAL CCSD
Résumé : International audience
The present study was conducted to assess the effects of Cd exposure on estrogen signaling in the zebrafish brain, as well as the potential protective role of Zn against Cd-induced toxicity. For this purpose, the effects on transcriptional activation of the estrogen receptors (ERs), aromatase B (Aro-B) protein expression and molecular expression of related genes were examined in vivo using wild-type and transgenic zebrafish embryos. For in vitro studies, an ER-negative glial cell line (U251MG) transfected with different zebrafish ER subtypes (ERα, ERβ1 and ERβ2) was also used. Embryos were exposed either to estradiol (E2), Cd, E2+Cd or E2+Cd+Zn for 72 h and cells were exposed to the same treatments for 30 h. Our results show that E2 treatment promoted the transcriptional activation of ERs and increased Aro-B expression, at both the protein and mRNA levels. Although exposure to Cd, does not affect the studied parameters when administered alone, it significantly abolished the E2-stimulated transcriptional response of the reporter gene for the three ER subtypes in U251-MG cells, and clearly inhibited the E2 induction of Aro-B in radial glial cells of zebrafish embryos. These inhibitory effects were accompanied by a significant downregulation of the expression of esr1, esr2a, esr2b and cyp19a1b genes compared to the E2-treated group used as a positive control. Zn administration during simultaneous exposure to E2 and Cd strongly stimulated zebrafish ERs transactivation and increased Aro-B protein expression, whereas mRNA levels of the three ERs as well as the cyp19a1b remained unchanged in comparison with Cd-treated embryos. In conclusion, our results clearly demonstrate that Cd acts as a potent anti-estrogen in vivo and in vitro, and that Cd-induced E2 antagonism can be reversed, at the protein level, by Zn supplement.
Journal of Applied Toxicology

Droits : info:eu-repo/semantics/OpenAccess
hal-01274217
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01274217
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01274217/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01274217/file/Inhibitory%20effect%20of%20Cadmium%20on%20estrogen_accepted.pdf
DOI : 10.1002/jat.3285

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The South Liaodong Peninsula massif is the easternmost Mesozoic Metamorphic Core Complex, recognized in Eastern China. It provides a good example of the combination of ductile shearing, synkinematic plutonism and polyphase exhumation. The Jurassic granodioritic plutons, located at the footwall of the detachment normal fault, and dated here at ca 160 Ma, recorded two different phases of cooling. A slow cooling regime of about 3-10°C/my prevailing before 122 Ma, was followed by a significant increase in cooling rate of about 40-55°C/my after that time. By contrast, a single fast cooling path was recorded by the Cretaceous monzogranite situated in the footwall of the detachment normal fault. This result indicates that the Jurassic and Cretaceous plutons recorded different exhumation processes: a Jurassic slow or negligible exhumation and a Cretaceous fast one assisted by normal faulting. These two cooling stages correspond to distinct geodynamic processes during the Jurassic and Cretaceous. Extensional tectonics seems not significant before Early Cretaceous. The second stage, dominated by an extensional regime which develops after ca 120 Ma, is tentatively correlated to the lithosphere removal of the North China Craton.
ISSN: 1367-9120

Droits : http://creativecommons.org/licenses/by-nc-nd/
insu-00528171
https://hal-insu.archives-ouvertes.fr/insu-00528171
https://hal-insu.archives-ouvertes.fr/insu-00528171/document
https://hal-insu.archives-ouvertes.fr/insu-00528171/file/Lin-JAsianEarthSciences-2010.pdf
DOI : 10.1016/j.jseaes.2010.09.007

Éditeur(s) : HAL CCSD Seoul National University
Résumé : http://www.episodes.org/backissues/302/abstract2.htm
International audience
The Trans-North China Belt (TNCB) is a Paleoproterozoic collisional orogen (ca. 1.9-1.8 Ga) responsible for the amalgamation of the North China Craton. Detail field works in Lüliangshan, Hengshan, Wutaishan and Fuping massifs where the belt is well exposed, allow us to draw new tectonic map and crustal-scale cross sections. The available petrologic, radiometric, geochronologic data are integrated in a geodynamic evolution scheme for this orogen. The Low Grade Mafic Unit (LGMU) is interpreted as an ophiolitic nappe rooted in a suture zone located in the western part of the Lüliangshan. This ophiolitic nappe overthrusts to the SE upon the Orthogneiss-Volcanites Unit (OVU) that consists of a bimodal volcanicsedimentary series metamorphosed under amphibolite facies conditions intruded by calcalkaline orthogneiss. The OVU is a composite Neoarchean-Paleoproterozoic magmatic arc developed during two stages (ca. 2500 and 2100 Ma) upon a continental basement corresponding to the western extension of the Neoarchean Fuping massif. The OVU overthrusts to the SE the Fuping massif along the Longquanguan shear zone. This stack of nappe, coeval with an amphibolite facies metamorphism, is dated at ca 1880 Ma. Subsequently, the metamorphic series experienced a widespread migmatization at 1850 Ma and was intruded by post-orogenic plutons dated at 1800 Ma. The weakly to unmetamorphosed Hutuo Supergroup unconformably overlies the metamorphosed and ductilely deformed units (OVU and LGMU), but it is also involved in a second tectonic phase developed in subsurface conditions. These structural features lead us to question the ca 2090 Ma age attributed to the Hutuo supergroup. Moreover, in the Fuping massif, several structural and magmatic lines of evidence argue for an earlier orogenic event at ca 2100 Ma that we relate to an older west-directed subduction below the Fuping Block. The Taihangshan Fault might be the location of a possible suture zone between the Fuping Block and an eastern one. A geodynamic model, at variance with previous ones, is proposed to account for the formation of the TNCB. In this scheme, three Archean continents, namely from West to East, the Ordos, Fuping and Eastern Blocks are separated by the Lüliang and Taihang Oceans. The closure of the Taihang Ocean at ca 2100 Ma by westward subduction below the Fuping Block accounts for the arc magmatism and the 2100 Ma orogeny. The second collision at 1900-1880 Ma between the Fuping and Ordos blocks is responsible for the main structural, metamorphic and magmatic features of the Trans-North China Belt.
ISSN: 0705-3797

insu-00152972
https://hal-insu.archives-ouvertes.fr/insu-00152972
https://hal-insu.archives-ouvertes.fr/insu-00152972/document
https://hal-insu.archives-ouvertes.fr/insu-00152972/file/Episodes_TNCB_Faure_et_al.pdf

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
In this contribution we present a reconstruction of the overall lithotectonic architecture, from inner zones to external ones, of the Paleoproterozoic Trans North China Orogen, within the North China Craton. Moreover, forward thermobarometrical modeling on a kyanite-bearing gneiss yields a reliable prograde P-T-t-D path. In addition, 40Ar/39Ar dating on rocks from distinct litho-tectonic units helps us to distinguish several tectono-metamorphic events during the orogenic development. Considering these results, we propose a geodynamic model involving three cratonic blocks, namely the Western, Fuping and Eastern Blocks, separated by two oceans, the Lüliang and Taihang Oceans. The opening of oceanic basins occurred around 2.2-2.3 Ga. After the westward subductions of oceanic lithosphere, the Trans-North-China Orogen was built up through a polyphase tectonic evolution within the period 1900-1800 Ma. The first event (D1) corresponded to the emplacement of lower and upper nappes herein called the Orthogneiss-and-Volcanites Unit (OVU) and the Low-Grade-and-Mafic Unit (LGMU), respectively. The syn-metamorphic D1 deformation (1880 ± 10 Ma) is characterized by a NW-SE stretching and mineral lineation with a top-to-the SE sense of shear. During ongoing compression of the thickening orogenic crust, a second deformation event D2 (1850 ± 10 Ma) was responsible for (1) syn-anatectic lateral flow and exhumation of the orogenic root and (2) folding of the middle and upper parts of the orogenic wedge that consequently acquired a fan-type geometry. The late D3 (1830 ± 10 Ma) and D4 (1810 ± 10 Ma) events are related to late-orogenic normal and strike-slip shearing, respectively. In our present state of knowledge, the Paleoproterozoic Trans-North China Orogen might be regarded as the assemblage of two continent-continent collisional belts, both of which are characterized by nappe stacking accommodated by top-to-the E/SE ductile shearing. Continental subduction, crustal thickening, partial melting of overthickened crust, exhumation of HP rocks and deposition of syn-orogenic detrital basins are typical features of modern collisional-type orogens.
ISSN: 0301-9268

Droits : info:eu-repo/semantics/OpenAccess
insu-00628119
https://hal-insu.archives-ouvertes.fr/insu-00628119
https://hal-insu.archives-ouvertes.fr/insu-00628119/document
https://hal-insu.archives-ouvertes.fr/insu-00628119/file/Trap-PrecambrianResearch-2011.pdf
DOI : 10.1016/j.precamres.2011.09.008

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Mechanism and kinematics of the Late Mesozoic continental extension event of eastern Asia are still debated. In order to better constrain its evolution, two granodioritic plutons of the Jiaodong Peninsula have been chosen as targets for a time-constrained palaeomagnetic study. Indeed, plutons are devoid of visible deformation, did not experience rotation along horizontal axis and are precisely dated by U/Pb and 40Ar/39Ar methods. Multidomain (MD) magnetite has been identified as the principal magnetic remanent carrier. The interpolation of existing and new U/Pb and 40Ar/39Ar ages revealed that characteristic remanent magnetisation was acquired in a narrow range of 116 ± 2 Ma. Twenty out of 27 sites present stable magnetic directions calculated from high-temperature or high-coercive components. The observations of the solo normal magnetic polarity for this palaeomagnetic collection and of the magnetic remanent age consistent with the Cretaceous Normal Superchron (CNS) argue that the characteristic magnetic remanence may be considered as primary. Detailed field observations of the intrusive relationship between the plutons and country rocks and Anisotropy of Magnetic Susceptibility (AMS) study reveal the absence of the subsequent deformation of plutons, or rigid rotation of plutons along a horizontal axis. Two palaeomagnetic poles have been therefore calculated from these plutons. Among 12 out 15 Cretaceous palaeomagnetic poles, including the two new poles provided by this study, from the Jiaodong Peninsula and on both sides of Tan-Lu and Muping-Jimo faults are statistically consistent. As a result, the Jiaodong Peninsula behaved as a rigid block as internal deformation appears negligible. The remaining three derived poles are probably due to the secular variation or/and the vicinity of fault zones near of the palaeomagnetic sampling site. Thus, they can not be applied to the peninsula-scaled tectonics. Comparison of these time52 constrained Cretaceous palaeomagnetic results of the Jiaodong Peninsula with those of North China Block (NCB) indicate that the Jiaodong Peninsula was rigidly attached to NCB since, 3 at least, the Cretaceous as residual difference is clearly insignificant with respect to the error brackets. These new palaeomagnetic results confirm that the relative clockwise (CW) rotation of Eastern Liaoning-Korea Block (ELKB) with respect to NCB does not affect the Jiaodong Peninsula as a rigid block, nevertheless, some tectonic structures have been reactivated since Cenozoic and local rotations could be produced. This palaeomagnetic study reveals that the Late Mesozoic extension in Eastern Asia is heterogeneously expressed in time and space. The complete understanding of the mechanism(s) of this extensional event needs further multidisciplinary investigations.
ISSN: 0031-9201

insu-00599546
https://hal-insu.archives-ouvertes.fr/insu-00599546
https://hal-insu.archives-ouvertes.fr/insu-00599546/document
https://hal-insu.archives-ouvertes.fr/insu-00599546/file/Charles_et_al_PEPI2011.pdf
DOI : 10.1016/j.pepi.2011.05.006

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
Investigation of an eclogite xenolith, discovered in a Cretaceous granite from the Central Domain of the Dabieshan massif in eastern China, yields new petrological insights into the high to ultrahigh-pressure metamorphism, experienced by the Qinling-Dabie orogen. Prior to inclusion as a xenolith in the granite during the Early Cretaceous, this eclogite xenolith had recorded a complex metamorphic evolution that complies with subduction and exhumation processes experienced by the continental crust of the South China Block. Well-preserved mineral parageneses substantiate the prograde and retrograde stages revealed by inclusions in porphyroblastic garnet and zoned minerals such as garnet, comphacite and amphibole in the matrix. The relatively low P/T re-equilibration during a latemetamorphic stage was textually inferred by the presence of aluminous and calcic-subcalcic amphiboles such as katophorite, edenite, taramite and pargasite as main matrix phases. According to our U/Pb, Rb/Sr and new 40Ar/39Ar geochronological results, namely 109 ± 1 and 112 ± 2 Ma plateau ages for muscovite and amphiboles, respectively, two successive but distinct cooling stages account for the thermal history of the granite–migmatite gneiss dome that forms the Central Dabieshan Domain. We argue that prior to the Cretaceous doming, the Central Dabieshan Domain experienced a tectono-metamorphic evolution similar to that observed in the high-pressure to ultra high-pressure units developed in the Southern Dabieshan Domain and Hong'an massif.
ISSN: 1437-3254

hal-00104224
https://hal-insu.archives-ouvertes.fr/hal-00104224
https://hal-insu.archives-ouvertes.fr/hal-00104224/document
https://hal-insu.archives-ouvertes.fr/hal-00104224/file/Lin-IntJEarthSciences-2007.pdf
DOI : 10.1007/s00531-006-0129-z

Éditeur(s) : HAL CCSD American Geophysical Union (AGU)
Résumé : International audience
In south China the Lushan massif forms a topographic high of the South China Block south of the Qinling-Dabie belt. The Lushan massif consists of two main lithotectonic units separated by a major tectonic contact: a Neoproterozoic (upper Sinian)-Paleozoic unit comprising primarily unmetamorphosed sandstones overlies a Paleoproterozoic unit mainly composed of low-pressure, high-temperature gneisses and micaschists. Both units are cut by Cretaceous granitic intrusions. Three primary tectono-metamorphic and magmatic events are recognized. The eastern part of the Lushan massif is cut by a NNE-SSW trending ductile normal fault (D3 deformation) coeval to the emplacement of a 100-110 Ma leucogranite dated by 40Ar/39Ar laserprobe on biotite and muscovite. D2 deformation is responsible for the formation of a decakilometer-scale NE-SW trending upright anticline characterized by NE-SW stretching and NW-SE shortening. The age of this folding event is defined by a 127±1 (2σ) Ma U/Pb titanite date obtained for a syntectonic granodiorite and 40Ar/39Ar ages of 133 Ma for amphibole. This Cretaceous age also corresponds to the 40Ar/39Ar ages of 126 Ma found on syntectonic muscovites at the base of the Sinian unit. An older deformation event, D1, characterized by a top-to-the-NW extensional decollement of the Sinian-Paleozoic series above Proterozoic metamorphic rocks is related to the Triassic tectonics of the Dabieshan. Lastly, in the lower part of Sinian rocks, the occurrence of kyanite cataclased during D1 documents an older, poorly preserved, late Paleozoic-early Mesozoic tectonometamorphic event (Dx) related to a blind thrust in the continental crust of the South China Block in the southern foreland of the Dabieshan.
ISSN: 0278-7407

insu-00717721
https://hal-insu.archives-ouvertes.fr/insu-00717721
https://hal-insu.archives-ouvertes.fr/insu-00717721/document
https://hal-insu.archives-ouvertes.fr/insu-00717721/file/Lin-Tectonics-2000.pdf
DOI : 10.1029/2000TC900009

Éditeur(s) : HAL CCSD University of Chicago Press
Résumé : International audience
In the North China block, the south Liaodong Peninsula massif is an elliptical metamorphic core complex (MCC) with a long axis trending NE‐SW. In cross‐section view, it is asymmetric, with a steeply dipping northwestern flank and a gently dipping southeastern flank. It consists of three lithotectonic units: a gneissic migmatite unit, a Paleo‐ to Meso‐Proterozoic micaschist‐slate unit, and a Neoproterozoic to Mesozoic sedimentary cover. Three deformation events related to extensional tectonics are distinguished in the study area: D1 is a ductile deformation related to the exhumation of the MCC; the following event, D2, corresponds to the development of recumbent folds formed during the early exhumation of the MCC; and the youngest event, D3, corresponds to brittle normal faulting that controlled the opening of a Cretaceous continental half‐graben basin. A pre‐D1 event characterized as northward verging is interpreted as the result of N‐S shortening that occurred in the Late Triassic during the final stages of the collision between the North and South China blocks. The ductile and brittle structures were developed coevally, with synkinematic plutonism and formation of half‐grabens. New 40Ar/39Ar and U/Pb Cretaceous ages obtained from the mylonitic granodiorite, gneissic migmatite, orthogneiss, and granite indicate that the south Liaodong Peninsula MCC is contemporaneous with other Cretaceous extensional structures, such as numerous syntectonic plutons bounded by ductile normal faults, MCC, and half‐graben basins, described in eastern China. Among the several hypotheses proposed to account for the Mesozoic extension along the eastern margin of Eurasia, lithosphere convective removal appears to be the most likely.
ISSN: 0022-1376

insu-00362879
https://hal-insu.archives-ouvertes.fr/insu-00362879
https://hal-insu.archives-ouvertes.fr/insu-00362879/document
https://hal-insu.archives-ouvertes.fr/insu-00362879/file/WeiLin-TheJournalofGeology-2008.pdf
DOI : 10.1086/527456

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
This paper presents a reappraisal of the tectonic evolution of the Zanhuang Massif that lies at the eastern margin of the Trans-North China Orogen, a continent–continent collision belt that marked the amalgamation of the North China Craton in Late Paleoproterozoic. Detailed field work with focus on geometries of structures and kinematics was performed. This was completed with LA-ICP-MS U–Pb analyses on zircon, EPMA U–Th/Pb dating on monazite and 40Ar/39Ar dating on amphibole. These studies led us to propose a new three-fold litho-tectonic subdivision of the massif: The Western Zanhuang Domain (WZD) made of TTG, migmatite and pink anatectic granite is correlated to the Fuping Massif that crops out to the north-west. Both areas represent a continental block, called the Fuping Block, which acquired most of its architecture around 2100 Ma ago. The Eastern Zanhuang Domain (EZD) made of TTG and migmatite represents the western edge of an Eastern Neoarchean Block. In between, the Central Zanhuang Domain (CZD) is a NE–SW trending stack of supracrustal, gneiss and mafic magmatic rocks thrust sheets displaced toward the ESE upon the Eastern Block. The lithological features suggest that the CZD represents the remnant of an oceanic basin, called the Taihang Ocean that closed during the amalgamation of the Eastern Block and the Fuping Block around 1880–1850 Ma. In agreement with recent work done along the western margin of the belt, in the Lüliang Massif, this study documents the amalgamation of the North China Craton in response to the closure of two oceanic basins, namely the Lüliang Ocean and the Taihang Ocean. West-dipping subductions and collisions involving three distinct continental blocks, called the Western, the Fuping and the Eastern Blocks, took place around 1880–1850 Ma.
ISSN: 0301-9268

insu-00403871
https://hal-insu.archives-ouvertes.fr/insu-00403871
https://hal-insu.archives-ouvertes.fr/insu-00403871/document
https://hal-insu.archives-ouvertes.fr/insu-00403871/file/Trap-PrecambrianResearch-2009.pdf
DOI : 10.1016/j.precamres.2009.03.011

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The Hengshan–Wutaishan area forms part of the Trans-North-China Belt developed in response to the final amalgamation of the North China Craton. The Hengshan–Wutaishan domain and the adjacent Fuping massif constitute the largest and the most representative rock exposure of the belt. A structural study allows us to redefine the lithological and tectonic units that compose the architecture of the Hengshan–Wutaishan domain and to propose that the Trans-North-China Belt was built up through a polyphase tectonic evolution within the period 1900–1800 Ma. The first event (D1) corresponds to the emplacement of lower and upper nappes herein called the Orthogneiss and Volcanites Unit (OVU) and the Low Grade Mafic Unit (LGMU), respectively. The OVU mainly consists of rocks formed in an arc system and metamorphosed under amphibolite facies conditions whereas the LGMU represents oceanic crust rocks with an arc component that underwent greenschist facies metamorphism. The syn-metamorphic D1 deformation is characterized by a NW–SE stretching and mineral lineation with a top-to-the SE sense of shear that corresponds to the sense of nappe motion. U–Th–Pb EPM chemical dating on monazite from three metapelites of the OVU gives isochron ages of 1884 ± 11 Ma, 1886 ± 5 Ma and 1887 ± 4 Ma interpreted as the age of the prograde amphibolite facies metamorphism coeval with nappe stacking during the D1 event. The D2 event corresponds to a widespread crustal melting of the OVU and underlying basement rocks in Hengshan related to the exhumation of deep structures about 20–30 Ma after nappe emplacement. The migmatite contains blocks of retrograded eclogite or HP-granulitic restites, and is characterized by the development of a pervasive foliation and lineation. A late D2 event represents the folding stage of the migmatitic foliation during the completion of a dome. The Orthogneiss and Volcanics Unit and the Low Grade Mafic Unit are unconformably covered by weakly metamorphosed to unmetamorphosed sediments belonging to the Hutuo Supergroup. These rocks were deformed by a ductile D3 event, characterized by a NW–SE trending stretching lineation, south verging folds associated with an axial planar slaty cleavage and an E–W crenulation lineation. Lastly, a left-lateral wrenching along the Zhujiafang Shear Zone separates the northern and southern parts of Hengshan. Our structural study shows that there is no significant difference between the southern part of Hengshan and the lower part of Wutaishan, both areas belong to OVU and show a structural continuity. We suggest that this polyphase deformation developed in response to a north-westward subduction of an old ocean, named the Lüliang Ocean, beneath the Western Block, followed by collision with a micro-continent named the Fuping Block at not, vert, similar1890–1880 Ma.
ISSN: 0301-9268

insu-00151594
https://hal-insu.archives-ouvertes.fr/insu-00151594
https://hal-insu.archives-ouvertes.fr/insu-00151594/document
https://hal-insu.archives-ouvertes.fr/insu-00151594/file/Trap-PrecambrainResearch-2007.pdf
DOI : 10.1016/j.precamres.2007.03.001

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : International audience
The Qinling–Dabie Belt represents the boundary between the North and South China Blocks (NCB, SCB, respectively), where ultrahigh-pressure (UHP) rocks are widespread. A structural study in eastern Qinling and zircon LA ICPMS dating of the migmatite that form the core of the Central Qinling Unit allows us to argue that continental collision occurred in Silurian, before 400 Ma. In the Late Palaeozoic, from Devonian to Permian, the northern margin of SCB experienced a continental rifting. From Late Permian to Middle Triassic, northward continental subduction of SCB is responsible for the development of a high-pressure metamorphism. The age of the UHP metamorphism remains unsettled yet. A two-time genesis, Early Palaeozoic and Early Triassic, is often preferred, but a single Palaeozoic age followed by a Triassic resetting cannot be ruled out.
ISSN: 1631-0713

Droits : info:eu-repo/semantics/OpenAccess
insu-00191534
https://hal-insu.archives-ouvertes.fr/insu-00191534
https://hal-insu.archives-ouvertes.fr/insu-00191534/document
https://hal-insu.archives-ouvertes.fr/insu-00191534/file/Faure-ComptesRendusGeoscience.pdf
DOI : 10.1016/j.crte.2007.10.007

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
BACKGROUND AND AIMS: Infection by hepatitis C virus is a worldwide health problem. An inadequate Th2 cytokine response promotes the fibrosis-cirrhosis fate. Immune-modulating molecules favoring a Th2 profile, such as HLA-G molecules of the HLA class Ib family, may play a role in chronic hepatitis. HLA-G contributes to the escape of tumors, and their involvement in viral infections has been increasingly described. The aim of this work was to study the expression of HLA-G in the liver, its cellular source and its regulation in cases of chronic C hepatitis. METHODS: HLA-G cells in blocks of liver derived from patients infected with HCV were labeled by immunohistochemistry and enumerated. Double immunofluorescence allowed the identification of the cellular source. HLA-G secretion by a human mast cell line was quantified by ELISA after various stimulations. After treatment with IFN-α real-time PCR was performed to determine the kinetics of cytokine expression profiles, followed by heat map clustering analysis. RESULTS: The number of HLA-G + cells was significantly associated with the area of fibrosis. For the first time, we identify the HLA-G+ cells as being mast cells. HLA-G secretion was significantly induced in human mast cells stimulated by IL-10 or interferons of class I. The transcriptome of the secretome of this cell line stimulated by IFN-α revealed that i) the HLA-G gene is upregulated late, ii) T lymphocytes and NK cells are recruited. CONCLUSIONS: These findings suggest an autocrine loop in the genesis of HCV liver fibrosis, based on mast cells expressing HLA-G.
ISSN: 0168-8278

hal-00874106
https://hal.archives-ouvertes.fr/hal-00874106
https://hal.archives-ouvertes.fr/hal-00874106/document
https://hal.archives-ouvertes.fr/hal-00874106/file/Amiot-Expression-HLA-G-revised.pdf
DOI : 10.1016/j.jhep.2013.09.006