Éditeur(s) : HAL CCSD American Physiological Society
Résumé : International audience
Excessive or persistent inflammation and hepatocyte death are the key triggers of liver diseases. The poly(ADP-ribose) polymerase (PARP) proteins induce cell death and inflammation. Chemical inhibition of PARP activity protects against liver injury during concanavalin A (ConA)-induced hepatitis. In this mice model, ConA activates immune cells, which promote inflammation and induce hepatocyte death, mediated by the activated invariant natural killer T (iNKT) lymphocyte population. We analyzed immune cell populations in the liver and several lymphoid organs, such as the spleen, thymus, and bone marrow in Parp2-deficient mice to better define the role of PARP proteins in liver immunity and inflammation at steady state and during ConA-induced hepatitis. We show that 1) the genetic inactivation of Parp2, but not Parp1, protected mice from ConA hepatitis without deregulating cytokine expression and leucocyte recruitment; 2) cellularity was lower in the thymus, but not in spleen, liver, or bone marrow of Parp2-/- mice; 3) spleen and liver iNKT lymphocytes, as well as thymic T and NKT lymphocytes were reduced in Parp2 knockout mice. In conclusion, our results suggest that the defect of T-lymphocyte maturation in Parp2 knockout mice leads to a systemic reduction of iNKT cells, reducing hepatocyte death during ConA-mediated liver damage, thus protecting the mice from hepatitis.NEW & NOTEWORTHY The genetic inactivation of Parp2, but not Parp1, protects mice from concanavalin A hepatitis. Immune cell populations are lower in the thymus, but not in the spleen, liver, or bone marrow of Parp2-deficient mice compared with wild-type mice. Spleen and liver invariant natural killer T (NKT) lymphocytes, as well as thymic T and NKT lymphocytes, are reduced in Parp2-deficient mice
ISSN: 0193-1857

hal-01630440
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01630440
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01630440/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01630440/file/102513_1_merged_1499199857-1.pdf
DOI : 10.1152/ajpgi.00436.2016

Éditeur(s) : HAL CCSD BRGM
Résumé : National audience
Proceedings 1ère Journée 'Alea Gravitaire'
Orléans, France

hal-00533951
https://hal.archives-ouvertes.fr/hal-00533951

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The Parentis and Arzacq-Mauleon basins located in front of the V-shaped oceanic propagator in the Bay of Biscay present evidence for extreme crustal thinning. In this paper we investigate the 3D structure of these rift basins, based on field observations and the interpretation of seismic data. We compare these results with those obtained from two different and independent inversion methods: first a 3D gravity inversion and second the standard Euler deconvolution.;For the Mauleon Basin our results show that the positive gravimetric anomaly identified above its southern margin is the consequence of two shallower high density bodies that are separated by the Pamplona fault and a deeper high density body. The high density bodies can be explained by the presence of mid-crustal and mantle rocks that were exhumed or uplifted at shallower depth during Early Cretaceous rifting before they were reworked and integrated to the Pyrenean chain during compression phase. Also, during this reactivation phase, some slices of the exhumed mid-crustal and mantle rocks were sheared off and were integrated in the present-day thrust belt in the Mauleon basin. For the Parentis Basin we can demonstrate, based on seismic data and gravimetric inversion methods, a decrease in extension from west to east, which is compatible with the V-shape geometry of the overall basin. Along strike, a change in the fault geometry from downward concave top-basement detachment faults to upward concave high-angle faults can be observed eastwards, i.e. towards the termination of the basin. A key structure, controlling the evolution of the Parentis Basin, is the east-west trending Ibis fault. We interpret this fault to have initially formed as a strike slip fault before it was reactivated during later crustal thinning. At present, it forms the limit between an upper plate sag basin to the north and a lower plate sag basin, floored at least locally by a top-basement detachment faults to the south. The strong asymmetry of the basin is supported by the shape of the basin and the results of standard Euler deconvolution.
ISSN: 0040-1951

hal-00523444
https://hal.archives-ouvertes.fr/hal-00523444
DOI : 10.1016/j.tecto.2010.04.023

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
We investigate the contribution of atmospheric and its induced non-tidal oceanic loading effects on surface time-varying gravity and tilt measurements for several stations in Western Europe. The ocean response to pressure forcing can be modelled accordingly to the inverted barometer, i.e. assuming that air pressure variations are fully compensated by static sea height changes, or using ocean general circulation models.Wevalidate two runs of theHUGO-mbarotropic ocean model by comparing predicted sea surface height variations with hundred tide-gauge measurements along the European coasts. We then show that global surface pressure field, as well as a barotropic high-resolution ocean model forced by air pressure and winds allow in most cases a significant reduction of the variance of gravity residuals and, to a smaller extends tilt residuals. Wefinally show that precise gravity measurements with superconducting gravimeters allow the observation of large storm surges, occurring in the North Sea, even for inland stations. However, we also confirm that the continental hydrology contribution cannot be neglected. Thanks to their specific sensitivity feature, only tiltmeters closest to the coast can clearly detect the loading due to these storm surges.
ISSN: 0264-3707

hal-00708046
https://hal.archives-ouvertes.fr/hal-00708046
https://hal.archives-ouvertes.fr/hal-00708046/document
https://hal.archives-ouvertes.fr/hal-00708046/file/ETS2008_BOY.pdf
BIBCODE : 2009JGeo...48..182B

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
We present the 1998-2009 GPS-derived velocity field for the Armenia region based on a survey-mode observation network of 31 GPS sites.We combine our results with previous GPS studies of the region to better assess the deformation of the Lesser Caucasus and Kura basin region. The results show that the Kura basin and the Lesser Caucasus regions are two different blocks, and that the main fault (Pambak-Sevan-Sunik) between these two regions has a right-lateral slip rate of 2±1 mm/yr. This is consistentwithmorphotectonic estimates and suggests a fairly constant slip rate over the last 120-300 ka. The right-lateral slip rate on one of the southern branch of the Pambak-Sevan-Sunik fault is lower than 1 mm/yr and the good agreementwith a geologically estimated slip rate suggests a constant slip rate over the last 1.4 Myr. The Sardarapat and Akhurian faults experience some shortening. This shortening is consistentwith someindependent geological estimates and shows the Arabian push.However, NNW-SSE-orientated faults have an extensional fault normal component instead of the expected shortening due to the Arabia-Eurasia convergence. This substantial extensive strain, and the sharp azimuth change of the velocity vectors between the Arabia promontory and the Lesser Caucasus suggest that processes other than "extrusion", possibly related to old subduction or delamination, contribute to the geodynamics of the region.
ISSN: 0040-1951

hal-00812623
https://hal.archives-ouvertes.fr/hal-00812623
DOI : 10.1016/j.tecto.2013.02.002

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The island of Taiwan is located on the convergent boundary between the Philippine Sea plate and the Chinese continental margin. It offers very active mountain building and collapsing processes well illustrated by the rugged topography, rapid uplift and denudation, young tectonic landforms, active faulting and numerous earthquakes. In this paper, using simple models, we have estimated vertical movements and associated absolute gravity variations which can be expected along a profile crossing the southern part of the island and probably suffering the highest rates of rising. The two different tectonic styles proposed for the island, thin-skinned and thick-skinned, were taken into account. Horizontal and vertical movements were modeled by an elastic deformation code. Gravity variations due to these deformations are then modeled at a second step. They are dominated by plate and free-air effects, i.e. elevation of the topography, with several mu Gal yr(-1). By comparison, gravity changes generated by mass transfers are weak: maximum 0.1 mu Gal yr(-1) with the thin-skinned tectonic and 0.3 mu Gal yr(-1) with the thick-skinned tectonic. Though elastic rheology has limitations, this modeling offers interesting results on what gravity signal can be expected from the AGTO project (Absolute Gravity in the Taiwanese Orogen), which proposes to study the dynamic of these mountain ranges using absolute gravimetry (AG) and also including relative gravimetry (RG) and GPS measurements.
ISSN: 0264-3707

hal-00456035
https://hal.archives-ouvertes.fr/hal-00456035
DOI : 10.1016/j.jog.2009.09.004

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : CCBY
National audience
ISSN: 0761-8425

hal-01117879
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01117879
PUBMED : 24314711
DOI : 10.1016/j.rmr.2013.09.007

Éditeur(s) : HAL CCSD
Résumé : International audience
After the 2009 Morakot typhoon, which triggered numerous large landslides in Taiwan, Mouyen et al. (2013)showed for the first time the potential of time-lapse gravity survey to infer the mass of sediments transferringby landsliding or through rivers. By providing an integrated measurement of masses, gravimetry might thus becomplementary to common methods used to assess the sediments discharge of rivers. But the masses of rocksdisplaced by Morakot were exceptionally large as a result of the record-breaking rainfalls brought by this typhoonand one might wonder to what extent time-lapse gravimetry could record such sediment transfers. In order tobetter assess the capabilities of this method, we set a time-lapse gravity network dedicated to the monitoring ofsuch sediments transfers in Paolai village (south-central Taiwan). Paolai is located near the large Laonong riverwhere temporary alluvial deposits of sediments exist and face steep mountain slopes likely to experience landslides.Both features are considered as potential source of mass transfers, and in turn of temporal gravity changes. Thefirst base gravity measurements were done in November 2015, using absolute and relative gravimeters, and will berepeated every year, before and after the typhoon season. In the same time, we also use a terrestrial lidar to scan thegeometry of both the river and the mountain slopes, hence providing a detailed topographical survey of the studiedarea. Adding Lidar measurements is an efficient strategy to solve for the non-uniqueness of gravity solutions.Meanwhile, we use the Eros morphodynamic model, that combine landsliding and flooding models, to investigatevarious scenarios of landsliding and subsequent sediment transport and compute the gravity changes on a virtualnetwork of gravimeters. This gives us insights on the expected order of magnitudes for these surface sedimenttransfers, which are useful to unravel the induced gravity signal from others sources such as local hydrology orvertical ground displacements. The modeling results also enable us to set network location that are best defined todetect mass changes associated with sediment transfer. The main objective of this study is to test whether timelapsegravity brings a new and reliable information compared to present methods monitoring sediments transfersand landscape evolution.
European Geosciences Union General Assembly 2016
Vienne, Austria

insu-01308554
https://hal-insu.archives-ouvertes.fr/insu-01308554

Éditeur(s) : HAL CCSD
Résumé : International audience
Idiopathic pulmonary fibrosis (IPF) is the most frequent chronic idiopathic interstitial pneumonia in adults. The management of rare diseases in France has been organised by a national plan for rare diseases, which endorsed a network of expert centres for rare diseases throughout France. This article is an overview of the executive summary of the French guidelines for the management of IPF, an initiative that emanated from the French National Reference Centre and the Network of Regional Competence Centres for Rare Lung Diseases. This review aims at providing pulmonologists with a document that: 1) combines the current available evidence; 2) reviews practical modalities of diagnosis and management of IPF; and 3) is adapted to everyday medical practice. The French practical guidelines result from the combined efforts of a coordination committee, a writing committee and a multidisciplinary review panel, following recommendations from the Haute Autorité de Santé. All recommendations included in this article received at least 90% agreement by the reviewing panel. Herein, we summarise the main conclusions and practical recommendations of the French guidelines.
Eur Respir Rev

hal-01063982
https://hal.archives-ouvertes.fr/hal-01063982
DOI : 10.1183/09059180.00001814
PUBMED : 24881074

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
ISSN: 0035-9009

hal-00372548
https://hal.archives-ouvertes.fr/hal-00372548
DOI : 10.1002/qj.386