Éditeur(s) : HAL CCSD Société géologique de France
Résumé : International audience
Age constraints on the protoliths, deformation, metamorphism and melting events are key parameters when correlating different continental lithospheric remnants among each other and disentangling their evolution within large-scale orogens. In situ U-Th-Pb chemical dating on monazites using Electron Probe Micro-Analyser (EPMA) has been performed on eight samples throughout the Variscan Maures-Tanneron massif (SE France) in order to date the medium to high-tectonothermal events related to the Variscan orogeny.Results indicate a polyphased crustal evolution : (i) U-Th-Pb ages obtained in polygenetic monazite grain cores gave inherited Upper Ordovician (456 ± 11 Ma) age, highlighting the large scale occurrence of the Ordovician magmatic activity in the North Gondwanian margin. An Early Devonian (404 ± 10 Ma) age may date a protolith emplacement related to calc-alkaline supra-subduction magmatism or could be associated to an early medium-grade metamorphism, prior to collisional stage. (ii) The crustal thickening stage has been further recorded in prograde metamorphic monazites formed during the underthrusting and subsequent nappe stacking events, under amphibolite facies conditions. This stage is dated between 382 ± 11 (Middle Devonian) and 331 ± 5 Ma (Late Visean). (iii) An orogenic partial melting event took place during Middle Carboniferous and is accompanied by the crystallization of crustal peraluminous magmas (Plan-de-la-Tour granite, 329 ± 3 Ma).This contribution demonstrates the capacity of monazite to record the prograde path of rocks during increasing metamorphic conditions related to stages of crustal thickening, and the robustness of the U-Th-Pb chronometer in monazite despite the overprinting of high-grade thermal events, including partial melting. The age ranges of the different orogenic stages reported in this study are in good agreement with those reported in adjacent Variscan Corsica and Sardinia; while correlations with other nearest Variscan massifs like the Argentera massif in the southwestern Alps or the French Massif Central remain more hypothetic. The Internal Zone of the Maures-Tanneron massif, and more widely the Internal Zone of the Maures-Tanneron-Corsica-Sardinia segment, is part of the southern orogenic root system of the Variscan belt.
EISSN: 1777-5817

insu-01140973
https://hal-insu.archives-ouvertes.fr/insu-01140973
DOI : 10.2113/gssgfbull.186.2-3.145

Éditeur(s) : HAL CCSD American Academy of Pediatrics
Résumé : International audience
OBJECTIVE: To explore the relationship between prenatal hemoglobin (Hb) concentration and infant cognitive and motor functions. METHODS: Our prospective cohort study included 1-year-old children born to women enrolled at their first antenatal care (ANC) visit in Allada, Benin, before 29 weeks of pregnancy, within a trial comparing the efficacy of sulfadoxine-pyrimethamine and mefloquine. Hb concentrations of pregnant women were determined from venous blood samples collected at first and second ANC visits of at least 1-month interval and at delivery. Women were prescribed oral iron, folic acid, and anthelminthics after the first ANC visit. A total of 636 children (76.8% of eligible children) were assessed by trained research nurses for cognitive and motor functions by using the Mullen Scales of Early Learning. RESULTS: Prevalence of anemia (Hb extless 110 g/L) decreased from 67.0% at first ANC visit (mean gestational age [SD], 22.1 [4.0] weeks) to 38.4% at delivery. Mean (SD) Hb concentrations increased from 103.7 (12.3) at first ANC visit to 112.4 (14.1) at delivery. We observed a significant negative quadratic relationship between infant gross motor (GM) function and Hb concentration at first and second ANC visits. Thus, infant GM scores increased sharply with increasing maternal Hb concentration until 90 g/L where increasing GM was mild, and began to decline after 110 g/L. CONCLUSIONS: There appears to be an Hb concentration range that may be optimal for GM function of 1-year-old children. This may reflect the importance of physiologic hemodilution, which occurs after the second trimester until 34 weeks of gestation
ISSN: 0031-4005

hal-01163752
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01163752
PUBMED : 26055847
DOI : 10.1542/peds.2015-0491

Éditeur(s) : HAL CCSD EDP Sciences
Résumé : The physiological ageing, the chronic conditions and the psycho-social environment are source of vulnerability to the old subject. These factors impact on the oral pathologies while the oral affections can deteriorate them on the contrary and lead the patient in the spiral of the decompensation. The clinical examination has to consist of a global approach of the eldely person, what confers it a specific character. Within the framework of this article, we propose a methodology of diagnostic survey bringing to light the necessity of interdisciplinary collaboration between the medical participants
Le vieillissement physiologique, les pathologies chroniques et l’environnement psychosocial sont source de vulnérabilité chez le sujet âgé. Ces facteurs impactent les pathologies bucco-dentaires alors que les affections orales peuvent à l’inverse les aggraver et conduire le patient dans la spirale de la décompensation. L’examen clinique doit consister en une approche globale de la personne âgée, ce qui lui confère son caractère spécifique. Dans le cadre de cet article, nous proposons une méthodologie d’enquête diagnostique mettant en évidence la nécessité de collaboration interdisciplinaire entre les intervenants médicaux
ISSN: 1760-611X

hal-01136939
https://hal.archives-ouvertes.fr/hal-01136939
DOI : 10.1 0 5 1 / a o s / 2 0 1 2 1 0 9

Éditeur(s) : HAL CCSD Muséum national d'histoire naturelle
Résumé :  
Le rôle déterminant de la faune dans les processus de dissémination, de prédation des graines et de régénération naturelle des arbres en forêt tropicale américaine a été mis en évidence par de nombreuses études menées notamment en Guyane française. Nombreux sont les arbres qui offrent des ressources alimentaires aux animaux frugivores et granivores et sont également des essences recherchées par les exploitants forestiers de ce département d'Outre-Mer. Les pistes forestières ouvertes pour l'exploitation du bois sont des voies facilitant l'accès de la forêt aux chasseurs, professionnels ou non, lorsque ce ne sont pas les exploitants eux-mêmes qui exercent une forte pression cynégétique. La question se pose alors de savoir si, dans l'optique d'une meilleure gestion des formations forestières pour une utilisation à long terme de la ressource bois, il ne faut pas se soucier sérieusement de la préservation de cette faune, maillon indispensable au maintien de la diversité en forêt. Autrement dit, les deux activités, exploitation forestière et chasse, sont-elles compatibles avec le maintien des processus de régénération forestière ?
ISSN: 0183-5173

hal-01032077
https://hal.archives-ouvertes.fr/hal-01032077

Éditeur(s) : HAL CCSD Thieme Publishing
Résumé : International audience
The aim of the present study was to compare the effects of prior cycling and a successive run on respiratory muscle performance during a cycle-run succession as performed in the triathlon. We hypothesized that despite the moderate intensity of exercise and the absence of exhaustion, the crouched cycling position would induce a decrease in respiratory muscle performance that would be reversed by the successive vertical run position. Ten male triathletes (22.6 +/- 1.1 yr) performed a four-trial protocol: (1) an incremental cycle test to assess maximal oxygen uptake (VO2max), (2) 20 min of cycling (C), (3) 20 min of running (R), and (4) 20 min of cycling followed by 20 min of running (C-R). Trials 2, 3 and 4 were performed at the same metabolic intensity, i. e., 75 % of VO2max. Respiratory muscle force was assessed by measuring maximal expiratory (P(Emax)) and inspiratory (P(Imax)) pressures from the functional residual capacity (FRC) before and 10 min after C, R, and C-R. Respiratory muscle endurance was assessed one day before and 30 min after C, R, and C-R, by measuring the time limit (T(lim)), which corresponds to the length of time a respiratory load can be sustained before the process of fatigue develops sufficiently to cause task failure. The results showed a similar significant decrease in P(Imax) (132.4 +/- 4.9 versus 125.7 +/- 5.6 cm H2O, p < 0.05) and T(lim) (5.22 +/- 0.28 versus 3.68 +/- 0.32 min, p < 0.05) post-C and post-C-R (133.7 +/- 4.0 versus 126.9 +/- 5.2 cm H2O, and 5.29 +/- 0.18 versus 3.49 +/- 0.41 min, respectively, p < 0.05) compared with the pre-trial values. In contrast, P(Imax) and T(lim) were not significantly decreased post-R (131.8 +/- 6.1 cm H2O versus 129.6 +/- 6.4 cm H2O, and 4.90 +/- 0.69 versus 4.40 +/- 0.56 min, respectively, p > 0.05). We concluded that moderate intensity exercise not performed to exhaustion induced a decrease in respiratory muscle performance. Moreover, the respiratory muscle fatigue induced by prior cycling was maintained, and neither reversed nor worsened, by the successive run.
ISSN: 0172-4622

hal-00720715
https://hal.univ-antilles.fr/hal-00720715

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
Glioblastoma (GB) is the most frequent and aggressive type of primary brain tumor. Recurrences are mostly located at the margin of the resection cavity in the peritumoral brain zone (PBZ). Although it is widely believed that infiltrative tumor cells in this zone are responsible for GB recurrence, few studies have examined this zone. In this study, we analyzed PBZ left after surgery with a variety of techniques including radiology, histopathology, flow cytometry, genomic, transcriptomic, proteomic, and primary cell cultures. The resulting PBZ profiles were compared with those of the GB tumor zone and normal brain samples to identify characteristics specific to the PBZ. We found that tumor cell infiltration detected by standard histological analysis was present in almost one third of PBZ taken from an area that was considered normal both on standard MRI and by the neurosurgeon under an operating microscope. The panel of techniques used in this study show that the PBZ, similar to the tumor zone itself, is characterized by substantial inter-patient heterogeneity, which makes it difficult to identify representative markers. Nevertheless, we identified specific alterations in the PBZ such as the presence of selected tumor clones and stromal cells with tumorigenic and angiogenic properties. The study of GB-PBZ is a growing field of interest and this region needs to be characterized further. This will facilitate the development of new, targeted therapies for patients with GB and the development of approaches to refine the per-operative evaluation of the PBZ to optimize the surgical resection of the tumor.
ISSN: 0167-594X

hal-01117083
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01117083
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01117083/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01117083/file/Characterizing%20the%20Peritumoral%20Brain%20Zone_accepted.pdf
DOI : 10.1007/s11060-014-1695-8

Éditeur(s) : HAL CCSD International Medical Press
Résumé : International audience
BACKGROUND: Psychiatric disorders are relatively common among HIV-infected patients. However, there are few studies about their potential risk factors. This analysis aimed to measure the incidence of severe psychiatric events (PE) among patients receiving combination antiretroviral therapy (cART) of the French APROCO-COPILOTE (ANRS CO8) cohort, and to identify the medical and socio-behavioural correlates of their first episode of depression, suicide or suicide attempt (D/S/SA). METHODS: APROCO-COPILOTE is a cohort of patients started on a protease inhibitor regimen between 1997 and 1999, with prospective medical standardized records and self-administered questionnaires collecting socio-demographic and socio-behavioural data. This analysis included all 11-year follow-up visits for 1,095 patients having completed baseline self-administered questionnaires. A proportional hazard Cox model was used to identify the correlates of a first D/S/SA event. RESULTS: The overall prevalence of severe PE remained low: 50 patients experienced 67 events (incidence rate [95% CI] =1.04 [0.82, 1.32] per 100 person-years). Depression (n=16), suicides (n=5) and suicide attempts (n=14) were the most frequently diagnosed PE (0.54 [0.39, 0.76] per 100 person-years) among 25 patients. Multivariate results showed that unemployment, unstable housing, detectable viral load and smoking more than 20 cigarettes/day were independently associated with D/S/SA. CONCLUSIONS: Although the incidence of severe PE remained relatively low among the patients of APROCO-COPILOTE cohort, this study's results underline a clinically important problem in HIV-infected patients receiving cART. Furthermore, our findings not only emphasize the importance of comprehensive care, especially for socially vulnerable patients, but may also help future studies designed to assess the effectiveness of interventions in reducing the risk of PE during cART.
ISSN: 1359-6535

hal-00875183
https://hal.archives-ouvertes.fr/hal-00875183
DOI : 10.3851/IMP2102
PUBMED : 22544079

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The occurrence of cyanobacterial blooms is drastically increasing in temperate countries and drinking water resources are threatened. As a result, cyanotoxins should be considered in water treatment to protect human health. This study presents a state of the art on cyanotoxins in water and their behaviour towards chlorination, a common drinking water disinfection process. Chlorination efficiency on cyanotoxins alteration depends on pH, chlorine dose and oxidant nature. Microcystins and cylindrospermopsin are efficiently transformed by chlorine, with respectively 6 and 2 by-products identified. In addition, chlorination of microcystins and cylindrospermopsin is associated with a loss of acute toxicity. Even though they have been less investigated, saxitoxins and nodularins are also altered by chlorine. For these toxins, no by-products have been identified, but the chlorinated mixture does not show acute toxicity. On the contrary, the fact that anatoxin-a has a very slow reaction kinetics suggests that this toxin resists chlorination.
ISSN: 0041-0101

hal-01122372
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01122372
DOI : 10.1016/j.toxicon.2009.10.028
PUBMED : 19874838

Éditeur(s) : HAL CCSD Elsevier Academic Press
Résumé : International audience
Marines Protected Areas (MPAs) are commonly used around the world as management tools to promote the sustainable use of marine resources. It is assumed that MPAs secure human livelihoods and well-being by protecting marine ecosystems and ecosystem services. However, the links between ecological effects of MPAs and services have rarely been explored. Here we review the different impacts of MPAs on ecosystem functioning and service provision. Results highlight that empirical evidence for positive effects of MPAs on ecosystem service provision by coastal marine ecosystems is accumulating. Finally, we identified knowledge gaps on which future research efforts could focus and empower marine resource managers to make more informed decisions and maximize the value derived from their natural resource base.
Aquatic Functional Biodiversity: an Ecological and Evolutionary Perspective

ISBN : 978-0-12-417015-5
hal-01199217
https://hal-univ-perp.archives-ouvertes.fr/hal-01199217
DOI : 10.1016/B978-0-12-417015-5.00009-8

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
Background: Neonatal infection constitutes one of Senegal’s most important public health problems, with amortality rate of 41 deaths per 1,000 live births.Methods: Between January 2007 and March 2008, 242 neonates with suspected infection were recruited at threeneonatal intensive care units in three major tertiary care centers in Dakar, the capital of Senegal. Neonatal infections wereconfirmed by positive bacterial blood or cerebrospinal fluid culture. The microbiological pattern of neonatal infectionsand the antibiotic susceptibility of the isolates were characterized. In addition, the genetic basis for antibiotic resistanceand the genetic background of third-generation cephalosporin-resistant (3GC-R) Enterobacteriaceae were studied.Results: A bacteriological infection was confirmed in 36.4 % (88/242) of neonates: 22.7 % (30/132) during the early-onsetand 52.7 % (58/110) during the late-onset periods (p > 0.20). Group B streptococci accounted for 6.8 % of the 88 collectedbacterial isolates, while most of them were Enterobacteriaceae (n = 69, 78.4 %). Of these, 55/69 (79.7 %) were 3GC-R. TheblaCTX-M-15 allele, the blaSHV and the blaTEM were highly prevalent (63.5, 65.4 and 53.8 %, respectively), usually associatedwith qnr genes (65.4 %). Clonally related strains of 3GC-R Klebsiella pneumoniae and 3GC-R Enterobacter cloacae, the twomost commonly recovered 3GC-R Enterobacteriaceae (48/55), were detected at the three hospitals, underlining the roleof cross-transmission in their spread. The overall case fatality rate was 18.6 %.Conclusions:Measures should be taken to prevent nosocomial infections and the selection of resistant bacteria
ISSN: 1471-2334

Droits : http://creativecommons.org/licenses/by/
hal-01473613
https://hal.archives-ouvertes.fr/hal-01473613
https://hal.archives-ouvertes.fr/hal-01473613/document
https://hal.archives-ouvertes.fr/hal-01473613/file/High%20third-generation%20cephalosporin%20resistant%20Enterobacteriaceae%20prevalence%20rate%20among%20neonatal%20infections%20in%20Dakar%2C%20Senegal.pdf
DOI : 10.1186/s12879-016-1935-y

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
The CoPanFlu-France cohort of households was set up in 2009 to study the risk factors for infection by the pandemic influenza virus (H1N1pdm) in the French general population. The authors developed an integrative data-driven approach to identify individual, collective and environmental factors associated with the post-seasonal serological H1N1pdm geometric mean titer, and derived a nested case-control analysis to identify risk factors for infection during the first season. This analysis included 1377 subjects (601 households). The GMT for the general population was 47.1 (95% confidence interval (CI): 45.1, 49.2). According to a multivariable analysis, pandemic vaccination, seasonal vaccination in 2009, recent history of influenza-like illness, asthma, chronic obstructive pulmonary disease, social contacts at school and use of public transports by the local population were associated with a higher GMT, whereas history of smoking was associated with a lower GMT. Additionally, young age at inclusion and risk perception of exposure to the virus at work were identified as possible risk factors, whereas presence of an air humidifier in the living room was a possible protective factor. These findings will be interpreted in light of the longitudinal analyses of this ongoing cohort.
ISSN: 1932-6203

Droits : http://creativecommons.org/licenses/by-sa/
hal-01122215
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01122215
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01122215/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01122215/file/journal.pone.0060127.pdf
PUBMED : 23613718

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
After Jurassic rifting, numerous carbonate platforms (i.e., the Orizaba, Cordoba and Golden Lane-Tuxpan platforms) developed during the Lower and Middle Cretaceous episode of thermal subsidence along the western passive margin of the Gulf of Mexico, with intervening basinal domains (i.e., the Tampico-Misantla, Zongolica, Veracruz and Deep Gulf of Mexico - DGM - basins).;During the Late Cretaceous-Paleocene, the east-verging Sierra Madre Oriental thrust belt developed, resulting in tectonic uplift and unroofing of the allochthonous units (i.e. tectonic units made up of former Orizaba and Cordoba platforms and Zongolica Basin series). This new topography provided also an important source of clastics to feed the adjacent foredeep, where coeval tectonic loading accounted for the bending of the foreland lithosphere. However, shallow water facies or even emersion persisted until the Eocene in the forebulge area (at the present location of the Golden Lane), preventing locally the clastics to reach the DGM. This topographic barrier was ultimately bypassed by the clastics only during the Oligocene and Neogene, once (1) the prograding clastic wedge had exceeded accommodation, and (2) the long lasting thermal subsidence of the passive margin could overpass the effect of the bending and force the former bulge to sink.;Numerous paleo-thermo-meters (Tmax, Ro), paleo-thermo-barometers (fluid inclusions), PVT and coupled forward kinematic and thermal modeling have been used to calibrate and date the progressive unroofing of the thrust belt. Coupled tectonic and sedimentologic modeling was applied in the foreland to predict the distribution of sand versus shale ratios in the Oligocene to Plio-Quaternary clastic sedimentary wedge of the passive margin, where gravitational gliding of post-Eocene series occurred during the Neogene along major listric faults.;Mantle dynamics are advocated as the main process accounting for post-orogenic uplift and regional tilting of the basement, which initiated a massive transfer of sediments from the Cordillera towards the Gulf of Mexico, from Oligocene onward, resulting in a destabilization and gravitational collapse of the western slope of the Gulf of Mexico in Neogene times.
ISSN: 0040-1951

hal-00445248
https://hal.archives-ouvertes.fr/hal-00445248
DOI : 10.1016/j.tecto.2009.04.012

Éditeur(s) : HAL CCSD Wiley-Blackwell
Résumé : International audience
UNLABELLED: Interleukin (IL)-33, a member of the IL-1 cytokine family, positively correlates with acute hepatitis and chronic liver failure in mice and humans. IL-33 is expressed in hepatocytes and is regulated by natural killer T (NKT) cells during concanavalin A (ConA)-induced acute liver injury. Here, we investigated the molecular mechanisms underlying the expression of IL-33 during acute hepatitis. The expression of IL-33 and its regulation by death receptor pathways was investigated after the induction of ConA-acute hepatitis in wildtype (WT), perforin(-/-) , tumor necrosis factor related apoptosis inducing ligand (TRAIL)(-/-) , and NKT cell-deficient (CD1d(-/-) ) mice. In addition, we used a model of acute liver injury by administering Jo2/Fas-antibody or D-galactosamine-tumor necrosis factor alpha (TNFα) in WT mice. Finally, the effect of TRAIL on IL-33 expression was assessed in primary cultured murine hepatocytes. We show that IL-33 expression in hepatocytes is partially controlled by perforin during acute liver injury, but not by TNFα or Fas ligand (FasL). Interestingly, the expression of IL-33 in hepatocytes is blocked during ConA-acute hepatitis in TRAIL-deficient mice compared to WT mice. In contrast, administration of recombinant murine TRAIL associated with ConA-priming in CD1d-deficient mice or in vitro stimulation of murine hepatocytes by TRAIL but not by TNFα or Jo2 induced IL-33 expression in hepatocytes. The IL-33-deficient mice exhibited more severe ConA liver injury than WT controls, suggesting a protective effect of IL-33 in ConA-hepatitis. CONCLUSION: The expression of IL-33 during acute hepatitis is dependent on TRAIL, but not on FasL or TNFα.
ISSN: 0270-9139

hal-00874194
https://hal.archives-ouvertes.fr/hal-00874194
PUBMED : 22961755
DOI : 10.1002/hep.25893

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The South Liaodong Peninsula massif is the easternmost Mesozoic Metamorphic Core Complex, recognized in Eastern China. It provides a good example of the combination of ductile shearing, synkinematic plutonism and polyphase exhumation. The Jurassic granodioritic plutons, located at the footwall of the detachment normal fault, and dated here at ca 160 Ma, recorded two different phases of cooling. A slow cooling regime of about 3-10°C/my prevailing before 122 Ma, was followed by a significant increase in cooling rate of about 40-55°C/my after that time. By contrast, a single fast cooling path was recorded by the Cretaceous monzogranite situated in the footwall of the detachment normal fault. This result indicates that the Jurassic and Cretaceous plutons recorded different exhumation processes: a Jurassic slow or negligible exhumation and a Cretaceous fast one assisted by normal faulting. These two cooling stages correspond to distinct geodynamic processes during the Jurassic and Cretaceous. Extensional tectonics seems not significant before Early Cretaceous. The second stage, dominated by an extensional regime which develops after ca 120 Ma, is tentatively correlated to the lithosphere removal of the North China Craton.
ISSN: 1367-9120

Droits : http://creativecommons.org/licenses/by-nc-nd/
insu-00528171
https://hal-insu.archives-ouvertes.fr/insu-00528171
https://hal-insu.archives-ouvertes.fr/insu-00528171/document
https://hal-insu.archives-ouvertes.fr/insu-00528171/file/Lin-JAsianEarthSciences-2010.pdf
DOI : 10.1016/j.jseaes.2010.09.007

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Isotopic fractionation of tritium is a highly relevant issue in radiation protection and requires certain radioecological considerations. Sound evaluation of this factor is indeed necessary to determine whether environmental compartments are enriched/depleted in tritium or if tritium is, on the contrary, isotopically well-distributed in a given system. The ubiquity of tritium and the standard analytical methods used to assay it may induce biases in both the measurement and the signification that is accorded to the so-called fractionation: based on an exhaustive review of the literature, we show how, sometimes large deviations may appear. It is shown that when comparing the non-exchangeable fraction of organically bound tritium (neOBT) to another fraction of tritium (e.g. tritiated water) the preparation of samples and the measurement of neOBT reported frequently led to underestimation of the ratio of tritium to hydrogen (T/H) in the non-exchangeable compartment by a factor of 5 % to 50 %. In the present study, corrections are proposed for most of the biological matrices studied so far. Nevertheless, the values of isotopic fractionation reported in the literature remain difficult to compare with each other, especially since the physical quantities and units often vary between authors. Some improvements are proposed to better define what should encompass the concepts of exchangeable and non-exchangeable fractions.
ISSN: 0160-4120

hal-01117744
https://hal.archives-ouvertes.fr/hal-01117744
https://hal.archives-ouvertes.fr/hal-01117744/document
https://hal.archives-ouvertes.fr/hal-01117744/file/Article%20review%20discrimination%20isotopique-envoy%C3%A9.pdf
DOI : 10.1016/j.envint.2013.12.020

Éditeur(s) : HAL CCSD
Résumé : Les dossiers thématiques d'Agropolis, n° 11
Dans le contexte actuel de contraintes climatiques et socioéconomiques, les agricultures des zones sèches doivent évoluer afin de s’adapter et de répondre à un double défi : produire plus pour satisfaire les besoins alimentaires importants de populations en croissance, mais aussi produire mieux de façon viable et durable. Pour cela, les agricultures de ces zones doivent évoluer vers des modes de production à la fois plus productifs, économes en ressources naturelles et résistants aux aléas climatiques.Dans ce cadre, l’ingénierie écologique propose de nouvelles alternatives de gestion des systèmes agro-sylvo-pastoraux caractéristiques des régions arides et semi-arides d’Afrique subsaharienne. Ceci implique de maitriser la complexité des systèmes étudiés et de s’inspirer à la fois du fonctionnement des écosystèmes naturels de référence à la région agroécologique concernée — les savanes pour les zones sèches ouest-africaines — et des pratiques traditionnelles et savoir-faire locaux issus d’une longue adaptation face aux contraintes environnementales.À partir des expériences ouest-africaines notamment, différentes options pratiques sont exposées dans ce dossier. On pourra ainsi agir sur la biodiversité des organismes, que ce soit les plantes ou les microorganismes du sol par exemple, favoriser le recyclage des matières organiques et des éléments nutritifs pour les plantes qui sont associées, maitriser les cycles de l’eau et, enfin, agir sur l’organisation des paysages pour favoriser un meilleur contrôle des ravageurs de culture.Cependant, développer une telle approche demande une vision intégrée du fonctionnement et de l’évolution des systèmes agro-sylvo-pastoraux. Les questions sociales — le foncier, l’urbanisation et les migrations — et économiques — les marchés des denrées de première nécessité, la pauvreté, etc. — sont des déterminants essentiels qu’il convient de prendre en compte pour le développement durable des populations dans les zones sèches en Afrique subsaharienne.
https://hal.archives-ouvertes.fr/hal-01585038

hal-01585038
https://hal.archives-ouvertes.fr/hal-01585038

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
Interleukin-27 (IL-27) belongs to the IL-6/IL-12 family of cytokines, associated with different inflammatory diseases and orchestrates its biological activity via common heterodimeric receptor composed of WSX-1 (IL-27Rα) and gp130. The present study was aimed to investigate the regulation of CXCL9, CXCL10, and CXCL11 chemokines in hepatic cells (human LX-2 cell line derived from normal human stellate cells (HSC), primary human hepatocytes, HSC, and HepG2 cells) and concanavalin A (ConA)-induced liver inflammation. We demonstrated that IL-27, but not IL-6, induced/up-regulated CXCR3 ligand genes (CXCL9, CXCL10, and CXCL11; out of 26 selected genes) in a STAT1-dependent manner in hepatic cells in vitro both at transcript and protein levels. In ConA-induced T cell-mediated hepatic model, we showed that soluble IL-27/IFNγ was elevated following ConA hepatitis in association with increased CXCL9, CXCL10, and CXCL11 expression in the liver. The exogenous IL-27 administration induced CXCR3 ligands in mouse liver at 4 h with any significant effect on recruitment of CXCR3(+) immune cells in the liver. The neutralization of IL-27 during ConA hepatitis differentially modulated (transcript vs protein expression) CXCR3 ligands and IFNγ during ConA-induced hepatitis with down-regulated expression of CXCL9 and CXCL10 at transcript level. The IFNγ, complementary regulated the expression of CXCR3 ligands as their up-regulation during ConA hepatitis, was abolished in IFNγ KO mice. In summary, IL-27 up-regulated the CXCL9, CXCL10, and CXCL11 chemokine expression in hepatic cells. IL-27 regulated CXCR3 ligand expression in IFNγ-dependent manner during acute hepatitis suggesting a complementary role of IL-27 and IFNγ to moderate liver inflammation via regulation of CXCR3 ligands. KEY MESSAGE: IL-27 up-regulated CXCR3 ligand expression in human hepatic cells in vitro. IL-27 up-regulated CXCR3 ligand expression and secretion in ConA hepatitis in vivo. CXCR3 ligand expression was down-regulated by blocking IL-27 or IFNγ deficiency. IL-27 modulated liver injury by regulation of CXCR3 ligands in IFNγ-dependent manner.
ISSN: 0946-2716

hal-01214006
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01214006
DOI : 10.1007/s00109-015-1319-6
PUBMED : 26199110

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Archives of Cardiovascular Diseases Supplements
Strasbourg, France

hal-01118035
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118035
DOI : 10.1016/S1878-6480(14)71283-2

Éditeur(s) : HAL CCSD Wiley-VCH Verlag
Résumé : International audience
Saccharopolyspora rectivirgula is the principal cause of farmer's lung disease (FLD). Serodiagnosis is based on immunoprecipitation techniques or enzyme immunoassays with homemade crude antigens and is not standardized. We aimed to produce specific recombinant antigens for the development of a standardized ELISA. We recruited 41 patients and 43 healthy exposed controls from five university hospital pneumology departments in France and Switzerland. S. rectivirgula proteins were extracted, separated by 2D electrophoresis, and subjected to Western blotting, with sera from FLD patients or controls. FLD-specific proteins were identified by MS and were produced as recombinant antigens. The diagnostic performance of ELISA tests using the recombinant antigens was assessed with all the sera from FLD patients and controls. We identified 25 FLD-specific proteins, some of which play important roles in transport, nutrition, or virulence. We produced 17 of these proteins as recombinant antigens and assessed their suitability for inclusion in the ELISA test. A combination of three of these proteins (SR1FA, SR17, and SR22) proved remarkably effective at discriminating between patients and controls, with a sensitivity of 83% and a specificity of 77%. The recombinant antigens produced in this study constitute a major step toward the improvement of diagnostic performance and the standardization of FLD serodiagnosis.
ISSN: 1862-8346

hal-01115880
https://hal.archives-ouvertes.fr/hal-01115880
DOI : 10.1002/prca.201400024
PUBMED : 25264606

Éditeur(s) : HAL CCSD
Résumé : International audience
Occupational exposure constitutes a common risk factor for lung cancer. We observed molecular alterations in 73% of never-smokers, 35% of men and 8% of women were exposed to at least one occupational carcinogen. We report herein associations between molecular patterns and occupational exposure.BioCAST was a cohort study of lung cancer in never-smokers that reported risk factor exposure and molecular patterns. Occupational exposure was assessed via a validated 71-item questionnaire. Patients were categorised into groups that were unexposed and exposed to polycyclic aromatic hydrocarbons (PAH), asbestos, silica, diesel exhaust fumes (DEF), chrome and paints. Test results were recorded for EGFR, KRAS, HER2, BRAF and PIK3 mutations, and ALK alterations.Overall, 313 out of 384 patients included in BioCAST were analysed. Asbestos-exposed patients displayed a significantly lower rate of EGFR mutations (20% versus 44%, p=0.033), and a higher rate of HER2 mutations (18% versus 4%, p=0.084). ALK alterations were not associated with any occupational carcinogens. The DEF-exposed patients were diagnosed with a BRAF mutation in 25% of all cases. Chrome-exposed patients exhibited enhanced HER2 and PIK3 mutation frequency.Given its minimal effects in the subgroups, we conclude that occupational exposure slightly affects the molecular pattern of lung cancers in never-smokers. In particular, asbestos-exposed patients have a lower chance of EGFR mutations.
European Respiratory Journal

hal-01647080
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01647080
DOI : 10.1183/13993003.00716-2017
PUBMED : 29074543