Éditeur(s) : HAL CCSD
Résumé : International audience
Partant du présupposé selon lequel les sciences, par leurs prétentions à l'universalité, constitueraient un terrain privilégié pour réunir des communautés fonctionnant sur des valeurs très différentes, notre recherche vise deux objectifs : la conception d'un outil permettant l'apprentissage des sciences à des enfants roms âgés de 6 à 8 ans, non scolarisés ; une évaluation de l'impact de cet outil en terme de scolarisation.
Un premier prototype a été conçu : une mallette contenant du matériel non coûteux et généralement disponible dans les foyers, permettant aux enfants de conduire aisément des expérimentations sur des sujets en relation avec des préoccupations proches de leur milieu de vie.
L'étude en cours concerne trois communautés roms de Roumanie, ayant de jeunes enfants non scolarisés. Lors d'une première visite, le matériel est présenté aux familles et les participants volontaires sont accompagnés lors de la réalisation des premières expérimentations. La mallette étant laissée à leur disposition, les familles sont visitées une seconde fois, un mois plus tard, pour discuter avec les utilisateurs des activités qu'ils ont pu conduire et leur apporter des explications.
On s'attend à ce que, au moyen de cet outil, les enfants accèdent à des connaissances scientifiques inaccessibles d'ordinaire au sein de leurs communautés et à ce que les familles transforment leur regard sur l'école et l'investissent comme moyen d'accéder à des connaissances utiles.
Nous présenterons dans cette communication les principes à la base de la conception des activités contenues dans la mallette, leur mise en œuvre dans les trois communautés ainsi que l'évaluation réalisée.
Différences et inéquités : enjeux culturels et scolaires pour les sciences et les techniques
Chamonix, France

halshs-00280412
https://halshs.archives-ouvertes.fr/halshs-00280412

Éditeur(s) : HAL CCSD
Résumé : International audience
La relation des papy-boomers avec le numérique est fortement stigmatisée. Perçus comme incompétents en la matière, ces jeunes seniors sont marginalisés, au profit de générations plus jeunes et plus « branchées ». Or, cette situation ne tient plus. Comme le montrent certaines études , l'attrait de ce public pour le numérique augmente chaque année. Si l'appétence digitale des papy-boomers s'intensifie, cela veut-il pour autant dire qu'ils deviennent experts en la matière ?Notre article se base sur les résultats d'une enquête exploratoire réalisée durant les cours d'informatique d'un centre social Girondin. Il s'agit ainsi d'identifier les solutions de médiation du savoir numérique auprès de ce public et de mettre ainsi en lumière les impacts de cette dernière sur le développement de la démocratie informationnelle liée au numérique. Le transfert de connaissances numériques pour la démocratisation du savoirchez les papy-boomers.
Les écosystèmes numériques et la démocratisation informationnelle : Intelligence collective, Développement durable, Interculturalité, Transfert de connaissances
Schoelcher, France

hal-01264953
https://hal.univ-antilles.fr/hal-01264953
https://hal.univ-antilles.fr/hal-01264953/document
https://hal.univ-antilles.fr/hal-01264953/file/Eloria%20VIGOUROUX-ZUGASTI.pdf

Éditeur(s) : HAL CCSD Nature Publishing Group
Résumé : International audience
Polarization dependence second harmonic generation (P-SHG) microscopy is gaining increase popularity for in situ quantification of fibrillar protein architectures. In this report, we combine P-SHG microscopy, new linear least square (LLS) fitting and modeling to determine and convert the complex second-order non-linear optical anisotropy parameter ρ of several collagen rich tissues into a simple geometric organization of collagen fibrils. Modeling integrates a priori knowledge of polyhelical organization of collagen molecule polymers forming fibrils and bundles of fibrils as well as Poisson photonic shot noise of the detection system. The results, which accurately predict the known sub-microscopic hierarchical organization of collagen fibrils in several tissues, suggest that they can be subdivided into three classes according to their microscopic and macroscopic hierarchical organization of collagen fibrils. They also show, for the first time to our knowledge, intrahepatic spatial discrimination between genuine fibrotic and non-fibrotic vessels. CCl 4-treated livers are characterized by an increase in the percentage of fibrotic vessels and their remodeling involves peri-portal compaction and alignment of collagen fibrils that should contribute to portal hypertension. This integrated P-SHG image analysis method is a powerful tool that should open new avenue for the determination of pathophysiological and chemo-mechanical cues impacting collagen fibrils organization.
ISSN: 2045-2322

hal-01592192
https://hal.archives-ouvertes.fr/hal-01592192
https://hal.archives-ouvertes.fr/hal-01592192/document
https://hal.archives-ouvertes.fr/hal-01592192/file/s41598-017-12398-0.pdf
DOI : 10.1038/s41598-017-12398-0

Éditeur(s) : HAL CCSD EDP Sciences
Résumé : International audience
In order to ensure a sustainable management of reef fisheries, data need to be collected regularly on the effect of these fisheries on both fish resources and the ecosystems that sustain them. Habitat and resources monitoring programs can provide such information, but are difficult to implement as they involve a range of technical, financial and human resources. Regarding these problems, the involvement of the local population in monitoring programs, called participatory monitoring, seems to offer solutions. Indeed, participatory monitoring has the potential of increasing the number of data collected at low cost, while taking advantage of the traditional ecological knowledge available locally. Some questions need clarifying, however: which methods can bring relevant information for the monitoring of reef fisheries while being appropriate to the motivations and skills of the local population? Is the degree of participation of the local population sufficient to make the monitoring program work, particularly over the long term? To answer these questions, participatory monitoring methods commonly used for coral reef ecosystems have been implemented to assess reef fisheries at three different sites: Moorea island and Tikehau atoll in French Polynesia, and the Bay of Tulear in Madagascar. While highlighting the relevance of some participatory monitoring programs for snapshot and large-scale surveys, the results of this study also show their lesser interest for regular data gathering on long-time scales. In any case, strong coordination and supervision by scientists are considered essential.
La gestion durable des écosystèmes coralliens nécessite de disposer d’informations régulières concernant l’impact des pêcheries sur les ressources récifales et sur les écosystèmes dont elles dépendent. Les suivis intégrés des ressources, des habitats et des espèces associées qui visent à fournir ce type d’informations sont difficiles à mettre en œuvre, car ils impliquent de nombreuses ressources humaines, techniques et financières. Face à ces problèmes, la participation de la société civile dans les programmes de suivi semble en mesure d’apporter des solutions. Dans le but de tester cette hypothèse, des méthodes de suivi participatif ont été mises en œuvre afin de caractériser des pêcheries récifales sur trois socio-écosystèmes contrastés : l’île de Moorea et l’atoll de Tikehau en Polynésie française, et le littoral de Tuléar à Madagascar. Les résultats de cette étude soulignent la pertinence de certains suivis participatifs pour fournir une vision écosystémique dans le cas de collecte de données ponctuelles et de large envergure, et leur intérêt moindre pour la collecte continue de données sur de longues échelles de temps. Dans tous les cas, une structure de coordination et l’implication de scientifiques s’avèrent primordiales pour assurer pérennité et fiabilité au système de suivi.
ISSN: 1240-1307

hal-01302983
https://hal-univ-perp.archives-ouvertes.fr/hal-01302983
DOI : 10.1051/nss/2013109

Éditeur(s) : HAL CCSD
Résumé : International audience
Divers auteurs ont relevé l'existence d'une épistémologie « spontanée » chez les enseignants, de nature empiriste et inductiviste, conforme à une certaine vision de l'histoire des sciences et de la pratique de la recherche scientifique. Le didacticien, s'il estime utile de tenter de déconstruire cette vision et d'en faire reconstruire une autre aux enseignants, afin que ceux-ci modifient dans ce sens leurs pratiques au nom d'une plus grande conformité avec le déroulement de la recherche scientifique, doit pouvoir justifier cette tentative, en s'appuyant sur les travaux des historiens des sciences et des épistémologues. Il lui sera dans le même temps utile de discerner certains des éléments qui sont à l'origine d'une conception qu'il juge erronée, ce que peut permettre, au moins partiellement, une analyse de l'impact des discours sur la méthode en sciences. Ces éléments permettent de dégager des pistes pour la formation des enseignants et des élèves.
ISSN: 2110-6460

Droits : info:eu-repo/semantics/OpenAccess
hal-01535167
https://hal.univ-antilles.fr/hal-01535167
https://hal.univ-antilles.fr/hal-01535167/document
https://hal.univ-antilles.fr/hal-01535167/file/Cariou_RDSTn%C2%B03_2011_Histoire%20des%20d%C3%A9marches%20en%20sciences%20et%20%C3%A9pist%C3%A9mologie%20scolaire.pdf

Éditeur(s) : HAL CCSD Dipartamento di Scienze della Terra, Università degli Studi di Modena
Résumé : International audience
The aim or this paper is to give an overall view of the natural hazards and risks affecting the French West Indies. These are mainly connected with hurricanes, volcanic eruptions and earthquakes which have caused several deaths and seriously weakened the local economy during the last three centuries. First of all the geological and geographical conditions which determine the natural predisposition of the French West Indies to geophysical and atmospheric hazards are described. Then the risk for the population is taken into account, both in terms of' the direct effects of the above mentioned hazards and of the side-effects, that is tidal waves, floods and mass movements. Finally the economic and social impact of natural disasters on the French West Indies and the difficulties arising in risk mitigation are shown.
Lo scopo di questo lavoro è di fornire un quadro generale dei rischi naturali che interessano le Antille Francese. Questi sono principalmente connessi con uragani, eruzioni vulcaniche e terremoti che, nel corso degli ultirni tre secoli hanno causato parecchi decessi e seriamente indebolito la economia locale. Vengono dapprima descritte le condizioni geologiche e geografiche che determinano la naturale predisposizione delle Antille Francese a minacche di tipo sia endogeno che esogeno. Viene poi considerato il rischio per la.popolazione, sia in termiini di effetti diretti dei fenomeni sopra citati che in termini di effetti marginali dovuti allo sviluppo di marernotti, alluvioni e frane. Infine viene considerato l’impatto sul tessuto sociale ed economico dei disastri di origine naturale nelle Antille Francese e le difficoltà che insorgono nella mitigazione del rischio.
The Erasmus 93-94 Programme in Geomorphology : Intensive Course in the French Antilles and Student Mobility

Droits : info:eu-repo/semantics/OpenAccess
ISBN : 88-900094-0-3
hal-01191892
https://hal.archives-ouvertes.fr/hal-01191892
https://hal.archives-ouvertes.fr/hal-01191892/document
https://hal.archives-ouvertes.fr/hal-01191892/file/D%27Ercole%201995%20-%20Natural%20hazards%20in%20the%20French%20West%20Indies.pdf

Éditeur(s) : HAL CCSD Springer International Publishing
Résumé : International audience
Understanding the formation processes of maritime archaeological sites and the maritime landscape in the French West Indies is a new challenge in underwater archaeology. This chapter presents an analysis of formation and conservation processes of maritime archaeological sites in Guadeloupe using evidence from both historical and archaeological research. Formation parameters include contemporary events associated with maritime loss and the in situ geophysical regime. Questions considered include: what natural and/or anthropogenic parameters best classify maritime sites in the context of the French West Indies landscape? And: how do these parameters vary by site location? Field-tested case studies are used to assess the archaeological potential for submerged shipwreck sites for three locational typologies within the landscape: submerged, coastal, and micro-island. Geomorphic parameters, including erosion, sea level evolution, and tectonic activity, are evaluated with regard to the formation of coastal Amerindian and colonial sites. The location of shipwrecks are primarily determined by historic patterns in commercial trade and by topographical constraints associated with accessibility, risk, and the presence of natural harbors, parameters important in the Caribbean. A unique feature of Guadeloupe is the high variability of the structure of the coastline through time. The recent discovery of numerous underwater prehistoric artifacts confirms that several islands, coastal areas, and their archaeological sites have been completely submerged or eroded since their formation. The characterization of these formation processes provides both academically interesting and practical information valuable in assessing the impact of development and urbanization in Guadeloupe’s maritime landscape.
Formation Processes of Maritime Archaeological Landscapes

hal-01448703
https://hal.archives-ouvertes.fr/hal-01448703

Éditeur(s) : HAL CCSD
Résumé : International audience
Graphomotor control constitutes a condition to the mastery of literacy and more widely to successful school apprenticeship. The Guadeloupian context is marked by significant rates of early school leaving and illiteracy. In such context, our research is concerned with two questions: “Does graphomotor training can help since kindergarten to strengthen graphomotor performances and the progression of literacy?” and “Which methodological approach can help to characterize the impact of graphomotor training?” By using online acquisition devices, we have tried to characterize the graphomotor skills for 132 pupils. These 3 to 5 years old children were submitted to 3 methods of graphomotor training. One of the methods that suppose family involvement, includes activities inspired by kid’s early scribbles. We considered the statistical analysis of the blind feedbacks of the teachers, of the features provided by the visuo-spatial processing of handwritten productions and of features provided by the sigma-lognormal modeling of the pupils’ movements. The results of this multimodal study show an increase in graphomotor control and in interest for drawing and handwriting tasks. The implication of these preliminary results on the pedagogical and co-educative choices is discussed.
Yves Mazabraud, Thomas Forissier, Alain Pietrus, Olivier Gros, Claire Anjou. CARIBBEAN ACADEMY OF SCIENCES 20 th GENERAL ASSEMBLY AND BIENNAL MEETING: Planning and Abstracts book. Nov 2016, Dehaies, Guadeloupe. 2016.
Deshaies, Guadeloupe

hal-01516420
https://hal.archives-ouvertes.fr/hal-01516420

Éditeur(s) : HAL CCSD
Résumé : International audience
Cette contribution souhaite réinterroger le modèle de gouvernance de la PME 2.0 (lui-même étant le résultat d’une combinatoire des actions stratégiques des différents groupes d’acteurs), modèle qui me semble impacté par un nouveau paradigme. C’est cette question que j’essaierai d’examiner sous la facette de l’apprentissage en double boucle d’Argirys et Schön, en lien avec les outils du web 2.0. Je pose par ailleurs l’hypothèse que les dirigeants doivent envisager un nouveau cadre cognitif pour la gouvernance de la PME. Celui-ci doit s’ancrer dans la vision d’une organisation en constante évolution et dont la dynamique est principalement issue de l’intelligence collective. Il convient dès lors de comprendre comment peut fonctionner cette intelligence collective et comment la stimuler ou tout du moins, ne pas entraver son rayonnement.
Les écosystèmes numériques et la démocratisation informationnelle : Intelligence collective, Développement durable, Interculturalité, Transfert de connaissances
Schoelcher, France

hal-01274179
https://hal.univ-antilles.fr/hal-01274179
https://hal.univ-antilles.fr/hal-01274179/document
https://hal.univ-antilles.fr/hal-01274179/file/Isabelle%20Choquet.pdf

Éditeur(s) : HAL CCSD John Libbey Eurotext
Résumé : International audience
The principal gynaecological cancers (breast, ovary, uterus, and cervix) account for over 40% of cancers found in women worldwide. However, large differences exist, in both their incidence and geographical distribution. The French West Indies, through their location, environment, socio-economic development, lifestyle, nutrition and the origins of their populations, constitute territories with a very particular character in the heart of the Caribbean. These characteristics have an impact on public health and can affect the incidence of tumours. We report for the first time the incidence of these major gynaecological cancers in Guadeloupe. Breast, ovary and uterine cancers have lower incidences in Guadeloupe than in mainland France. By contrast, cervical cancer is more frequent in Guadeloupe than in mainland France. The mortality rates associated with breast cancer, ovary and uterine cancer are also lower in Guadeloupe than in mainland France, whereas the opposite pattern is observed for cervical cancer. These observations may be accounted for in part by a difference in the prevalence of established or suspected risk factors for each of these types of cancer.
ISSN: 0007-4551

inserm-00504624
http://www.hal.inserm.fr/inserm-00504624
DOI : 10.1684/bdc.2008.0810
PUBMED : 19258222

Éditeur(s) : HAL CCSD MDPI
Résumé : International audience
The number and amount of man-made chemicals present in the aquatic environment has increased considerably over the past 50 years. Among these contaminants, endocrine-disrupting chemicals (EDCs) represent a significant proportion. This family of compounds interferes with normal hormonal processes through multiple molecular pathways. They represent a potential risk for human and wildlife as they are suspected to be involved in the development of diseases including, but not limited to, reprotoxicity, metabolic disorders, and cancers. More precisely, several studies have suggested that the increase of breast cancers in industrialized countries is linked to exposure to EDCs, particularly estrogen-like compounds. Estrogen receptors alpha (ERα) and beta (ERβ) are the two main transducers of estrogen action and therefore important targets for these estrogen-like endocrine disrupters. More than 70% of human breast cancers are ERα-positive and estrogen-dependent, and their development and growth are not only influenced by endogenous estrogens but also likely by environmental estrogen-like endocrine disrupters. It is, therefore, of major importance to characterize the potential estrogenic activity from contaminated surface water and identify the molecules responsible for the hormonal effects. This information will help us understand how environmental contaminants can potentially impact the development of breast cancer and allow us to fix a maximal limit to the concentration of estrogen-like compounds that should be found in the environment. The aim of this review is to provide an overview of emerging estrogen-like compounds in the environment, sum up studies demonstrating their direct or indirect interactions with ERs, and link their presence to the development of breast cancer. Finally, we emphasize the use of in vitro and in vivo methods based on the zebrafish model to identify and characterize environmental estrogens.
ISSN: 2073-4425

hal-01616486
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01616486
DOI : 10.3390/genes8090229
PUBMED : 28914763
PUBMEDCENTRAL : PMC5615362

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Sickle cell anemia (SCA) and hemoglobin SC (HbSC) disease are the two most common forms of sickle cell disease (SCD), a frequent hemoglobinopathy which exhibits a highly variable clinical course. Although high levels of microparticles (MPs) have been consistently reported in SCA and evidence of their harmful impact on the SCA complication occurrences have been provided, no data on MP pattern in HbSC patients has been reported so far. In this study, we determined and compared the MP patterns of 84 HbSC and 96 SCA children, all at steady-state, using flow cytometry. Most of circulating MPs were derived from platelets (PLTs) and red blood cells (RBCs) in the two SCD syndromes. Moreover, we showed that HbSC patients exhibited lower blood concentration of total MPs compared to SCA patients, resulting mainly from a decrease of MP levels originated from RBCs and to a lesser extent from PLTs. We did not detect any association between blood MP concentrations and the occurrence of painful vaso-occlusive crises, acute chest syndrome and pulmonary hyper-tension in both patient groups. We also demonstrated for the first time, that whatever the considered genotype, RBC-derived MPs exhibited higher externalized phosphatidylserine level and were larger than PLT-derived MPs.
ISSN: 1932-6203

hal-01668322
https://hal.univ-antilles.fr/hal-01668322
https://hal.univ-antilles.fr/hal-01668322/document
https://hal.univ-antilles.fr/hal-01668322/file/journal.pone.0177397.pdf
DOI : 10.1371/journal.pone.0177397

Éditeur(s) : HAL CCSD Editions Paralia CFL
Résumé : Les lagunes du Golfe du Lion constituent un patrimoine naturel reconnu ainsi qu'un enjeu essentiel pour les activités économiques locales. Leur évolution morphologique est donc une question importante dans le contexte actuel de changements climatiques et environnementaux. L'analyse de données topo-bathymétriques du système des étangs Palavasiens a permis de mieux cerner son évolution depuis le XVIIIème siècle. Les actions anthropiques et les apports du bassin versant apparaissent comme les facteurs principaux de l'évolution du système. Au cours des 40 dernières années, le système montre une tendance à se combler lentement avec une accumulation moyenne de 1,3 mm/an. Des différences de fonctionnement sur chacun des étangs sont mises en lumière en fonction des forçages naturels et anthropiques locaux. Lagoons of the Gulf of Lion, recognized for their natural heritage, are a key challenge for local economic activities. Their morphological evolution is an important issue in the current context of climate and environmental changes. Analysis of topo-bathymetric data of the Palavasian lakes system has helped to clarify its evolution since the XVIII th century. Human impacts and contributions from the watershed appear to be the main drivers governing the evolutionof the system. Over the past40 years, the system shows a tendency to slowly fill at an accumulation rate of 1.3 mm/year. Differences between lagoons are highlighted according to local natural and anthropogenic forcings.
ISSN: 1760-8716

hal-00854075
https://hal.archives-ouvertes.fr/hal-00854075
DOI : 10.5150/revue-paralia.2011.007

Éditeur(s) : HAL CCSD Wiley-VCH Verlag
Résumé : International audience
Proteomic profiling plays a decisive role in the elucidation of molecular signatures representative of a specific clinical context. MuStem cell-based therapy represents a promising approach for clinical applications to cure Duchenne Muscular Dystrophy (DMD). To expand our previous studies collected in the clinically relevant DMD animal model, we decided to investigate the skeletal muscle proteome four months after systemic delivery of allogenic MuStem cells. Quantitative proteomics with isotope-coded protein labelling (ICPL) was used to compile quantitative changes in the protein expression profiles of muscle in transplanted Golden Retriever Muscular Dystrophy (GRMD) dogs as compared to GRMD dogs. A total of 492 proteins were quantified, including 25 that were overrepresented and 46 that were underrepresented after MuStem cell transplantation. Interestingly, this study demonstrates that somatic stem cell therapy impacts on the structural integrity of the muscle fascicle by acting on fibres and its connections with the extracellular matrix. We also show that cell infusion promotes protective mechanisms against oxidative stress and favours the initial phase of muscle repair. This study allows us to identify putative candidates for tissue markers that might be of great value in objectively exploring the clinical benefits resulting from our cell-based therapy for DMD.
ISSN: 1615-9853

Droits : info:eu-repo/semantics/OpenAccess
hal-01332030
https://hal.archives-ouvertes.fr/hal-01332030
https://hal.archives-ouvertes.fr/hal-01332030/document
https://hal.archives-ouvertes.fr/hal-01332030/file/Quantitative%20proteome%20profiling%20of%20dystrophic%20dog%20skeletal%20muscle_accepted.pdf
DOI : 10.1002/pmic.201600002

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Millimeter Waves (MMW) will be used in the next-generation of high-speed wireless technologies, especially in future Ultra-Broadband small cells in 5G cellular networks. Therefore, their biocompatibilities must be evaluated prior to their massive deployment. Using a microarray- based approach, we analyzed modifications to the whole genome of a human keratinocyte model that was exposed at 60.4 GHz-MMW at an incident power density (IPD) of 20 mW/cm2 for 3 hours in athermic conditions. No keratinocyte transcriptome modifications were observed. We tested the effects of MMWs on cell metabolism by co-treating MMW-exposed cells with a glycolysis inhibitor, 2-deoxyglucose (2dG, 20 mM for 3 hours), and whole genome expression was evaluated along with the ATP content.We found that the 2dG treatment decreased the cellular ATP content and induced a high modification in the transcriptome (632 coding genes). The affected genes were associated with transcriptional repression, cellular communication and endoplasmic reticulum homeostasis. The MMW/ 2dG co-treatment did not alter the keratinocyte ATP content, but it did slightly alter the transcriptome, which reflected the capacity of MMWto interfere with the bioenergetic stress response. The RT-PCR-based validation confirmed 6 MMW-sensitive genes (SOCS3, SPRY2, TRIB1, FAM46A, CSRNP1 and PPP1R15A) during the 2dG treatment. These 6 genes encoded transcription factors or inhibitors of cytokine pathways, which raised questions regarding the potential impact of long-term or chronic MMW exposure on metabolically stressed cells. © 2016 Soubere Mahamoud et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ISSN: 1932-6203

hal-01367149
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01367149
DOI : 10.1371/journal.pone.0160810
PUBMED : 27529420

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Perinatal exposure to endocrine-disrupting chemicals may affect thyroid hormones homeostasis and impair brain development. Chlordecone, an organochlorine insecticide widely used in the French West Indies has known estrogenic and progestin properties, but no data is available, human or animal, on its action on thyroid hormone system. Our aim was to evaluate the impact of perinatal exposure to chlordecone on the thyroid hormone system of a sample of infants from the Timoun mother-child cohort in Guadeloupe and their further neurodevelopment. Chlordecone was measured in cord blood and breast milk samples. Thyroid stimulating hormone (TSH), free tri-iodothyronine (FT3), free thyroxine (FT4) were determined in child blood at 3 months (n=111). Toddlers were further assessed at 18 months using an adapted version of the Ages and Stages Questionnaire (ASQ). Cord chlordecone was associated with an increase in TSH in boys, whereas postnatal exposure was associated with a decrease in FT3 overall, and in FT4 among girls. Higher TSH level at 3 months was positively associated with the ASQ score of fine motor development at 18 months among boys, but TSH did not modify the association between prenatal chlordecone exposure and poorer ASQ fine motor score. Perinatal exposure to chlordecone may affect TSH and thyroid hormone levels at 3 months, differently according to the sex of the infant. This disruption however did not appear to intervene in the pathway between prenatal chlordecone exposure and fine motor child development.
ISSN: 0013-9351

hal-01134317
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01134317
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01134317/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01134317/file/Perinatal%20exposure%20to%20chlordecone_accepted.pdf
PUBMED : 25747818

Éditeur(s) : HAL CCSD
Résumé : International audience
In real world situations, each person is generally in contact with only a small fraction of the entire population and exchange information through these interactions. Their number and their frequency vary from one to another individual and may be much depending on mobility of individuals. The objective of this article is to better understand how human mobility may have an impact on mobile social networking systems. This should help to answer a question as: "How might an information, a rumor, a pathogen, etc., driven by physical proximity, spread through a population?". We present a first stage of our work in which we focus on percolation processes as information flow mechanisms. We propose a synthetic mobility model and we define an artificial world populated by heterogeneous agents who differ in their mobility. Simulations are conducted on a multi-agent programmable environment. Our experimental results clearly demonstrate positive correlations between agent mobility factors and percolation thresholds.
Procedia CS

hal-00767043
https://hal.archives-ouvertes.fr/hal-00767043
DOI : 10.1016/j.procs.2012.06.007

Éditeur(s) : HAL CCSD Lippincott, Williams & Wilkins
Résumé : International audience
OBJECTIVES: The ANRS-112 INTERPRIM trial assessed whether fixed-cycles of antiretroviral treatment interruption (ART-STI) combined or not with pegylated interferon alpha-2b (peg-IFN) could lower viral load and achieve a healthier immune system in patients diagnosed during primary HIV-1-infection (PHI). DESIGN AND METHODS: Patients were randomized to receive either continuous ART (cART) during 72 weeks, or cART during 36 weeks followed by three ART-STIs, or the same ART-STIs associated with peg-IFN during the first 14 weeks and each interruption (ART-STI-IFN). Treatment was stopped at week 72. Final evaluation was based on plasma HIV-RNA level 6 months after the last treatment interruption. RESULTS: Eighty-seven percent of patients achieved undetectable HIV-RNA at week 32, with no deleterious impact of sequential treatment interruptions (STIs). Viral rebounds during interruptions were lower in the ART-STI-IFN than in the ART-STI group and during the second and third interruptions compared with the first one. However, HIV-RNA levels, CD4 T-cell counts and CD4 T/CD8 T ratios were similar between groups after the 6-month interruption, with a persistent effect on CD4 T cells and total cell-associated HIV-DNA levels. Predictive factors of virological outcome were HIV-RNA and HIV-DNA levels at PHI and HIV-DNA levels at treatment interruption. HIV-specific responses did not differ between strategies and were not associated with outcome. Forty-eight percent of patients experienced treatment resumption during long-term follow-up without difference between groups. CONCLUSION: When initiated during PHI, STIs associated or not with IFN did not result in a different outcome as compared to cART. All regimens showed a high response rate and a sustained immunological benefit after cessation.
ISSN: 0269-9370

hal-00875175
https://hal.archives-ouvertes.fr/hal-00875175
DOI : 10.1097/QAD.0b013e32835844d9
PUBMED : 22842994

Éditeur(s) : HAL CCSD American Society for Investigative Pathology
Résumé : International audience
Recent studies suggest that psoriasis may be more severe in patients with nonalcoholic fatty liver disease, particularly in those with the inflammatory stage of steatohepatitis [nonalcoholic steatohepatitis (NASH)]. Herein, we investigated the impact of diet-induced steatohepatitis on the severity of imiquimod-induced psoriasiform dermatitis. Mice fed with a high-fat diet developed steatohepatitis reminiscent of human NASH with ballooning hepatocytes and significant liver fibrosis. Mice with steatohepatitis also displayed moderate cutaneous inflammation characterized by erythema, dermalinfiltrates of CD45(+) leukocytes, and a local production of IL-17A. Moreover, steatohepatitis was associated with an epidermal activation of caspase-1 and cutaneous overexpression of IL-1 beta. Imiquimod-induced psoriasiform dermatitis was exacerbated in mice with steatohepatitis as compared to animals fed with a standard diet. Scale formation and acanthosis were aggravated, in correlation with increased IL-17A and IL-22 expression in inflamed skins. Finally, intradermal injection of IL-17A in standard diet-fed mice recapitulated the cutaneous pathology of mice with steatohepatitis. The results show that high-fat diet induced steatohepatitis aggravates the inflammation in psoriasiform dermatitis, via the cutaneous production of IL-17A. In agreement with clinical data, this description of a novel extrahepatic manifestation of NASH should sensitize dermatologists to the screening and the management of fatty liver in psoriatic patients.
ISSN: 0002-9440

hal-01390977
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01390977
DOI : 10.1016/j.ajpath.2016.05.012
PUBMED : 27423696

Éditeur(s) : HAL CCSD Wiley
Résumé : Genetic variation is generally considered a prerequisite for adaptation to new environmental conditions. Thus the discovery of genetically depauperate but geographically widespread species is unexpected. We used 12 paternally inherited chloroplast microsatellites to estimate population genetic variation across the full range of an emblematic circum-Mediterranean conifer, stone pine (Pinus pinea L.). The same chloroplast DNA haplotype is fixed in nearly all of the 34 investigated populations. Such a low level of variation is consistent with a previous report of very low levels of diversity at nuclear loci in this species. Stone pine appears to have passed through a severe and prolonged demographic bottleneck, followed by subsequent natural- and human-mediated dispersal across the Mediterranean Basin. No other abundant and widespread plant species has as little genetic diversity as P. pinea at both chloroplast and nuclear markers. However, the species harbors a nonnegligible amount of variation at adaptive traits. Thus a causal relationship between genetic diversity, as measured by marker loci, and the evolutionary precariousness of a species, cannot be taken for granted
ISSN: 0014-3820

hal-01032062
https://hal.archives-ouvertes.fr/hal-01032062
DOI : 10.1111/j.1558-5646.2007.00294.x