Éditeur(s) : Université des Antilles Études caribéennes
Résumé : El Caribe colombiano ha experimentado un acelerado proceso de urbanización y desarrollo turístico en los últimos 50 años. Solo en una ciudad como Cartagena de Indias (la ciudad turística por excelencia de Colombia), datos referidos al periodo noviembre 2009 – enero 2015, mostraron un incremento en la llegada de turistas cercano al 20%. Después de un gran número de encuestas realizadas alrededor del mundo, se encontró que los parámetros en que se basan los turistas a la hora de preferir una playa son: i) la seguridad, ii) el paisaje, iii) calidad del agua, iv) basuras, v) instalaciones. El paisaje es uno de los recursos costeros y por lo tanto su evaluación es una herramienta importante para los gestores y planificadores del litoral a la hora de la realización de planes de conservación, protección, desarrollo y manejo. Este trabajo se basa en la evaluación del valor paisajístico de las playas que constituyen la base de la economía de muchas ciudades costeras en el mundo y en especial de la zona central de litoral Caribe colombiano. Un problema importante en la evaluación del paisaje es la incapacidad de algunas metodologías de reflejar correctamente las percepciones de la gente, debido al alto peso que tienen algunos aspectos subjetivos (p. ej. altura de una geoforma).En este trabajo se presenta la evaluación del paisaje realizada para la zona central de Caribe colombiano (37 playas de los departamentos de Sucre, Bolívar y Atlántico) utilizando la lógica matemática y matrices ponderadas (fuzzy logic mathematics - parameter weighting matrices) las cuales permiten disminuir la subjetividad y cuantificar con exactitud la incertidumbre. Para la evaluación se utilizó una lista de chequeo que está conformada por 26 parámetros, 18 físicos (acantilados, playas, plataformas rocosas, dunas, características de los valles, forma del relieve, mareas, paisaje costero, color del agua y restos de vegetación), y 8 antropogénicos (ruido, basura, descarga de aguas residuales, grado de modificación y de construcción del medio, tipos de acceso, línea del horizonte y estructuras antrópicas). Los parámetros fueron calificados en una escala de 1 a 5 (presencia/ausencia o poca/alta calidad) y, con el fin de cuantificar la incertidumbre y excesos derivados de la subjetividad que pudo haber tenido la evaluación de los parámetros, se utilizó la lógica difusa (fuzzy logic). A la par, un sistema de matrices, se empleó para asignar valores de peso de acuerdo a las preferencias y prioridades de los usuarios. Como resultado de estos análisis lógico-estadísticos se obtuvo un valor (D) el cual resume la evaluación del paisaje en 5 clases que van desde la CLASE 1 (zona litoral sumamente atractiva) hasta la CLASE 5 (playas urbanas muy poco atractivas). De los 37 sectores estudiados, ninguno puede ser considerado como una zona litoral sumamente atractiva, mientras que 15 corresponden a zonas litorales urbanas poco atractivas, el resto de las playas (22) se ubicó entre las clases 2, 3 y 4. Los resultados obtenidos son útiles para los gestores costeros en la medida que, aunque no es posible mejorar los aspectos naturales de la clasificación, si es posible mejorar muchos de los parámetros antropogenicos y, de esta forma, hacer que una playa mejore su clasificación y sea paisajísticamente más atractiva.
In the past few years, the Colombian Caribbean coast has experienced rapid tourism development which has not been accompanied with a similar increase in urbanization facilities. For example, the city of Cartagena de Indias (the most famous tourist destination of Colombia), data related to November 2009 – January 2015 period, showed an increase of 20% in tourist arrivals. A large number of surveys developed in Europe found that the most critical parameters for tourists, when they choose a beach, are: i) security, ii) scenery, iii) water quality, iv) litter, v) facilities. Scenery is one of the most significant coastal resources. Therefore, its evaluation is a valuable tool for coastal managers when developing conservation and protection plans. This proposal provides coastal scenery assessment of 37 beaches along the North Colombian Caribbean littoral by analysing 26 physical and human factors. Results were weighted (not all parameters have equal weight) and subjected to fuzzy logic mathematics in order to reduce recorder judgment subjectivity. The sites were categorised into five classes; Class 1 locations had top grade scenery; Class 5 poor scenery. Of the 37 sectors studied, currently none can be considered as an extremely attractive coastal area (class1), while 15 were unattractive urban coastal areas (class 5), the rest of the beaches (22) placed in classes 2, 3 and 4. Classification of analysed sites depends on the geological setting and degree of human occupation. The technique opens new perspectives for analysis of the potential for coastal tourism development in natural areas and scenic quality improvement of current tourist developed areas. Concerning coastal management issues, emphasis should be given to the upgrading of human parameters eliminating litter and sewage evidence, vegetation debris and enhancing beach nourishment works. This proposal can help in moving some locations from their present status to a higher one.
Caraïbes
Colombie

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.9326
http://journals.openedition.org/etudescaribeennes/9326

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Marine protected areas (MPAs) are a global conservation and management tool to enhance the resilience of linked social-ecological systems with the aim of conserving biodiversity and providing ecosystem services for sustainable use. However, MPAs implemented worldwide include a large variety of zoning and management schemes from single to multiple-zoning and from no-take to multiple-use areas. The current IUCN categorisation of MPAs is based on management objectives which many times have a significant mismatch to regulations causing a strong uncertainty when evaluating global MPAs effectiveness. A novel global classification system for MPAs based on regulations of uses as an alternative or complementing the current IUCN system of categories is presented. Scores for uses weighted by their potential impact on biodiversity were built. Each zone within a MPA was scored and an MPA index integrates the zone scores. This system classifies MPAs as well as each MPA zone individually, is globally applicable and unambiguously discriminates the impacts of uses.
ISSN: 0308-597X

Droits : http://creativecommons.org/licenses/by-nc-nd/
hal-01358706
https://hal-univ-perp.archives-ouvertes.fr/hal-01358706
https://hal-univ-perp.archives-ouvertes.fr/hal-01358706/document
https://hal-univ-perp.archives-ouvertes.fr/hal-01358706/file/1-s2.0-S0308597X16300197-main.pdf
DOI : 10.1016/j.marpol.2016.06.021

Éditeur(s) : HAL CCSD Frontiers Media
Résumé : International audience
To date 142 species have been described in the Vibrionaceae family of bacteria, classified into seven genera; Aliivibrio, Echinimonas, Enterovibrio, Grimontia, Photobacterium, Salinivibrio and Vibrio. As vibrios are widespread in marine environments and show versatile metabolisms and ecologies, these bacteria are recognized as one of the most diverse and important marine heterotrophic bacterial groups for elucidating the correlation between genome evolution and ecological adaptation. However, on the basis of 16S rRNA gene phylogeny, we could not find any robust monophyletic lineages in any of the known genera. We needed further attempts to reconstruct their evolutionary history based on multilocus sequence analysis (MLSA) and/or genome wide taxonomy of all the recognized species groups. In our previous report in 2007, we conducted the first broad multilocus sequence analysis (MLSA) to infer the evolutionary history of vibrios using nine housekeeping genes (the 16S rRNA gene, gapA, gyrB, ftsZ, mreB, pyrH, recA, rpoA, and topA), and we proposed 14 distinct clades in 58 species of Vibrionaceae. Due to the difficulty of designing universal primers that can amplify the genes for MLSA in every Vibrionaceae species, some clades had yet to be defined. In this study, we present a better picture of an updated molecular phylogeny for 86 described vibrio species and 10 genome sequenced Vibrionaceae strains, using 8 housekeeping gene sequences. This new study places special emphasis on (1) eight newly identified clades (Damselae, Mediterranei, Pectenicida, Phosphoreum, Profundum, Porteresiae, Rosenbergii, and Rumoiensis); (2) clades amended since the 2007 proposal with recently described new species; (3) orphan clades of genomospecies F6 and F10; (4) phylogenetic positions defined in 3 genome-sequenced strains (N418, EX25, and EJY3); and (5) description of V. tritonius sp. nov., which is a member of the “Porteresiae” clade.
ISSN: 1664-302X

hal-01546980
http://hal.upmc.fr/hal-01546980
DOI : 10.3389/fmicb.2013.00414

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
CK chondrites are highly oxidized meteorites containing abundant magnetite and trace amounts of Fe,Ni metal. Although the group is predominately composed of equilibrated meteorites (types 4-6), in recent years a significant number of new samples have been classified as being either CK3 or CK3-anomalous. These unequilibrated CKs often display a close affinity with members of the CV oxidized subgroup. CKs and CVs (oxidized subgroup) may therefore form a continuum and by implication could be derived from a single common parent body. To investigate the relationship between these two groups a detailed study of the oxygen isotope composition, opaque mineralogy and major and trace element geochemistry of a suite of CV and CK chondrites has been undertaken. The results of oxygen isotope analysis confirm the close affinity between CV and CK chondrites, while excluding the possibility of a linkage between the CO and CK groups. Magnetites in both CV and CK chondrites show significant compositional similarities, but high Ti contents are a diagnostic feature of the latter group. The results of major and trace element analysis demonstrate that both CV and CK chondrites show overlapping variation. Supporting evidence for a single common source for both groups comes from their similar cosmic-ray exposure age distributions. Recent reflectance spectral analysis is consistent with both the CVs and CKs being derived from Eos family asteroids, which are believed to have formed by the catastrophic disruption of a single large asteroid. Thus, a range of evidence appears to be consistent with CV and CK chondrites representing samples from a single thermally stratified parent body. In view of the close similarity between CV and CK chondrites some modification of the present classification scheme may be warranted, possibly involving integration of the two groups. One means of achieving this would be to reassigned CK chondrites to a subgroup of the oxidized CVs. It is recognized that a full evaluation of this proposal may require further study of the still poorly understood CK3 chondrites.
ISSN: 0016-7037

hal-00474633
https://hal.archives-ouvertes.fr/hal-00474633
DOI : 10.1016/j.gca.2009.11.029

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Glioblastoma (GB), the most frequent primary tumor of the central nervous system, remains one of the most lethal human cancers despite intensive researches. Current paradigm in the study of GB has been focused on inter-patient variability and on trying to isolate new classification elements or prognostic factors. Here, using ICPL, a technique for protein relative quantification by mass spectrometry, we investigated protein expression between the four regions of GB on clinically relevant biopsies from 5 patients. We identified 584 non-redundant proteins and 31 proteins were found to be up-regulated in the tumor region compared to the peri-tumoral brain tissue, among which, 24 proteins belong to an interaction network linked to 4 biological processes. The core of this network is mainly constituted of interactions between beta-actin (ACTB) with heat shock proteins (HSP90AA1, HSPA8) and 14-3-3 proteins (YWHAZ, YWHAG, YWHAB). A cluster of three isoforms of the sodium pump α-subunit (ATP1A1, ATP1A2, ATP1A3) was also identified outside this network. The differential expression observed for ACTB and 14-3-3γ was further validated by western blot and/or immunohistochemistry. Our study confirms the identity of previously proposed molecular targets, highlights several functional processes altered in GB such as energy metabolism and synaptic transmission and could thus provide added value to new therapeutic trails.
ISSN: 1874-3919

hal-00877756
https://hal.archives-ouvertes.fr/hal-00877756
DOI : 10.1016/j.jprot.2012.04.034
PUBMED : 22575386

Éditeur(s) : HAL CCSD Society for the Study of Reproduction
Résumé : International audience
Matrix-assisted laser desorption/ionization (MALDI) tissue imaging mass spectrometry is particularly promising among the numerous applications of mass spectrometry. It is used for probing and analyzing the spatial arrangement of a wide range of molecules, including proteins, peptides, lipids, drugs, and metabolites, directly in thin slices of tissue. In the field of proteomics, the technology avoids tedious and time-consuming extraction and fractionation steps classically required for sample analysis. MALDI imaging mass spectrometry is increasingly recognized as a powerful method for clinical proteomics, particularly in cancer research. The technology has particular potential for the discovery of new tissue biomarker candidates, classification of tumors, early diagnosis or prognosis, elucidating pathogenesis pathways, and therapy monitoring. Over recent years, MALDI imaging mass spectrometry has been used for molecular profiling and imaging directly in male and female reproductive tissues. This review will consider some of the recent publications in the field, addressing a range of issues covering embryo development, gene expression product profiling during gametogenesis, and seeking and identifying biomarkers of reproductive cancers. The wealth of advances in mass spectrometry imaging will inevitably attract biologists and clinicians as the advantages and power of this technology become more widely known. This review will also discuss bottlenecks and the many technical issues that remain to be resolved before laboratories in the field can adopt the technology. We foresee that MALDI imaging mass spectrometry will have a major impact in reproductive research by opening new avenues to the understanding of various molecular mechanisms and the diagnosis of reproductive pathologies.
ISSN: 0006-3363

hal-00877851
https://hal.archives-ouvertes.fr/hal-00877851
DOI : 10.1095/biolreprod.111.094896
PUBMED : 22156474

Éditeur(s) : HAL CCSD
Résumé : Over the last decade, distance-based methods have been introduced and then improved in the field of spatial economics to gauge the geographic concentration of activities. There is a growing literature on this theme including new tools, discussions on their specific properties and various applications. However, there is currently no typology of distance-based methods. This paper fills that gap. The proposed classification helps understand all the properties of distance-based methods and proves that they are variations on the same framework.
https://halshs.archives-ouvertes.fr/halshs-00679993

halshs-00679993
https://halshs.archives-ouvertes.fr/halshs-00679993
https://halshs.archives-ouvertes.fr/halshs-00679993v5/document
https://halshs.archives-ouvertes.fr/halshs-00679993/file/MARCON-PUECH-Hal%2000679993v5.pdf

Éditeur(s) : John Libbey Eurotext ltd
Résumé : The new sustainable development data repository requires new analysis grids, in particular for factors accounted for in productive system typologies. This paper, based on the aquaculture example, analyses the diversity in aquaculture systems with respect to sustainable development. Various typologies are obtained by evaluating structural and functional approaches integrating variables related to production and regulation systems and to the territorial insertion of fish farms. Categories have been defined on a scale based on a set of five sites, which are representative of a wider range of aquaculture systems. Use of these categories goes beyond the local typologies and prepares a generic meta-typology classification for the systems. This generic classification is then compared to the views of sustainable development held by the fish farmers working on the various types of farms.
Cahiers Agricultures (1166-7699) (John Libbey Eurotext ltd), 2009-04 , Vol. 18 , N. 2 , P. 199-210

Droits : 2009 John Libbey Eurotext ltd
http://archimer.ifremer.fr/doc/2009/publication-6560.pdf
DOI:10.1684/agr.2009.0297
http://archimer.ifremer.fr/doc/00000/6560/

Résumé : Les travaux de recherche présentés dans ce mémoire s'inscrivent dans la lignée des approches de modélisation hydrologiques prédictives dirigées par les données. Nous avons particulièrement développé leur application sur le contexte difficile des phénomènes de crue éclairs caractéristiques des bassins versants de la région Caraïbe qui pose un dé fi sé.curi taire. En envisageant le problème de la prévision de crues comme un problème d'optimisation combinatoire difficile nous proposons d'utiliser la notion de métaneuristiques, à travers les algorithmes évolutionnaire notamment pour leur capacité à parcourir efficacement de grands espaces de recherche et fi fournir des solutions de bOlIDe qualité en des temps d'exécution raisonnables. Nous avons présenté l'approche de prédiction AV2D : Aggregate Variable Data Driven dom le concept central est la notion de variable agrégée. L'idée sous-jacente à ce concept est de considérer le pouvoir prédictif de nouvelles variables définies comme le résultat de fonctions tatistiques, dites d'agrégation calculées sur de donnée' correspondant à des périodes de temps précédent uo événem nt à prédire. Ces variable sont caractérisées par des ensembles de paramètres correspondant a leur pJ:opriétés. Nous avons imroduitle variables agrégées hydrométéorologiques permettant de répondre au problème de la classification d événements hydrologiques. La complexité du parcours de l'espace de recherche engendré par les paramètres définissant ces variables a été prise en compte grâce à la njse en oeuvre d'un algorithme évolutionnaire particulier dont les composants ont été spécifiquement définis pour ce problème. Nous avons montré, à travers une étude comparative avec d'autres approches de modélisation dirigées par les données, menée sur deux cas d'études de bassins versant caribéens, que l'approche AV2D est particulièrement bien adaptée à leur contexte. Nous étudions par la suite les bénéfices offerts par les approches de modélisation hydrologiques modulaires dirigées par les données, en définissant un procédé de division en sous-processus prenant en compte les caractéristiques paniculières des bassins versants auxquels nous nous intéressons. Nou avons proposé une extension des travaux précédents à travers la définition d'une approche de modélisation modulaire M2D: Spatial Modular Data Driven, consistant à considérer des sous-processus en divisant l'ensemble des exemples à classifier en sous-ensembles correspondant à des comportements hydrologiques homogènes. Nous avons montré à travers une étude comparative avec d autres approches dU'igées par les données mises en oeuvre sur les mêmes sous-ensembles de données que celte approche permet d améliorer les résultats de prédiction particulièrement à coun Lenne. Nous avons enfin proposé la modélisation d un outil de pi
The work presented in this thesis is in the area of data-driven hydrological modeling approaches. We particularly investigared their application on the difficult problem of flash flood phenomena typically observed in Caribbean watersheds. By considering the problem of flood prediction as a combinatorial optimization problem, we propose to use the notion of Oleraheuristics, through evolutionary algorithms, especially for their capacity ta visit effjciently large search space and to provide good solutions in reasonable execution times. We proposed the hydrological prediction approach AV2D: Aggregate Variable Data Driven which central concept is the notion of aggregate variable. The underlying idea of this [concept is to consider the predictive power of new variables defined as the results of statistical functions, called aggregation functions, computed on data corresponding ta time periods before an event ta predict. These variables are characterized by sets of parameters corresponding ta their specifications. We introduced hydro-meteorological aggregate variables allowing ta address the classification problem of hydrological events. We showed through a comparative study on two typical caribbean watersheds, using several common data driven modelling techniques that the AV2D approach is panicul.rly weil fitted ta the studied context. We also study the benefits offered by modulaI' approaches through the definition of the SM2D: Spatial Modular DataDriven approach, consisting in considering sub-processes partly defined by spatial criteria. We showed that the results obtained by the AV2D on these sub-processes allows to increase the performances particularly for short term prediction. Finally we proposed the modelization of a generic control tool for hydro-meteorological prediction systems, H2FCT: Hydro-meteorological Flood Forecasting Control 1'001

http://www.theses.fr/2013AGUY0673/document

Éditeur(s) : HAL CCSD INVS
Résumé : National audience
Context – Cervical cancer is the second most frequent cancer of women in French Guiana. Studies have shown that populations living in remote villages in the interior of the territory have early sexual relations and that multiple sexual partnerships are frequent. Hence, the main objective of the study was to determine the prevalence of Human Papilloma Virus (HPV) in these areas.Methods – This multicentric cross sectional study was conducted in women aged 20 to 65 years, living in theremote villages along the Maroni and Oyapock rivers. Women were included on a voluntary basis after beinginformed of the study team schedule through radio address and key opinion leaders.The search for HPV and cytologic examinations were performed on each sample. HPV infection was defined bythe detection of viral DNA using the Greiner Bio One® kit. Cytologic analyses were performed using the 2001Bethesda classification.Results – Overall, 643 women were included in the study. Age-standardized HPV prevalence was 35%. Theprevalence curve by age group showed a U-shaped pattern: women over 50 years had the highest risk of being infected by HPV, followed by women aged 20-29 years. In addition, 26.1% of women with a normal smear test had HPV infection. The most frequent genotypes were HPV52, HPV58, and HPV16. On interpretable smears 1.16% of women had high grade superficial intra-epithelial (HSIL) lesions.Conclusions – The standardized prevalence of HPV in French Guiana is among the highest in the world. HSILcytological lesions were nearly 4 times more frequent than in the Île-de-France region. Given the importance of the incidence of cervical cancer in French Guiana, these results suggest it may be preferable to use HPV testing than cytology. Vaccination against HPV, preferably with the new nonavalent vaccine seems an appropriate prevention measure. However, this intervention will be a challenge to implement in this region where a significant proportion of the population is not covered by health insurance.
Contexte – Le cancer du col de l’utérus est le deuxième cancer féminin le plus fréquent en Guyane française.Des études ont montré que les populations résidant dans les communes isolées de l’intérieur du départementdébutent leur vie sexuelle de façon précoce et que le multipartenariat sexuel y est fréquent. Dans ce contexte, l’objectif principal de cette étude était de déterminer la prévalence de l’infection à papillomavirus humains (HPV) dans ces zones.Méthodes – Cette étude transversale multicentrique a été conduite auprès des femmes âgées de 20 à 65 ansrésidant dans les communes isolées des fleuves Maroni et Oyapock. Les femmes étaient incluses sur la basedu volontariat après avoir été informées du passage de l’équipe de l’étude via la radio locale et par les leadersd’opinion. La recherche d’infection à HPV et les analyses cytologiques ont été réalisées sur chaque prélèvement. L’infection à HPV était définie par la détection d’ADN viral par le kit de dépistage Greiner Bio One®. Les analyses cytologiques ont été décrites selon la classification de Bethesda 2001.Résultats – Au total, 643 femmes ont été incluses. La prévalence de l’infection à HPV, standardisée sur l’âge,était de 35%. La courbe de prévalence par classe d’âge présentait une forme en U : les femmes de plus de50 ans avaient le plus haut risque d’être infectées par HPV, suivies par les femmes âgées de 20 à 29 ans.Par ailleurs, 26,1% des femmes ayant un frottis normal étaient infectées par le HPV. Les génotypes les plusfréquents étaient HPV52, HPV58 et HPV16. Sur les frottis interprétables, 1,16% des femmes avaient des lésions de haut grade (type HSIL).Conclusions – Le taux standardisé de prévalence de l’infection par le HPV en Guyane est parmi les plus élevésau monde. Les lésions cytologiques de type HSIL étaient près de 4 fois plus fréquentes qu’en Île-de-France.Étant donné l’importance de l’incidence du cancer du col de l’utérus en Guyane, ces résultats montrent qu’il est peut être préférable d’utiliser le test HPV plutôt que la cytologie. La vaccination anti-HPV, de préférence avec le nouveau vaccin nonavalent, semble être une mesure de prévention appropriée. Pour autant, cela reste un challenge de mettre en oeuvre ces interventions dans cette région où une part importante de la population n’a pas d’assurance maladie.
ISSN: 1953-8030

Droits : info:eu-repo/semantics/OpenAccess
inserm-01407222
http://www.hal.inserm.fr/inserm-01407222
http://www.hal.inserm.fr/inserm-01407222/document
http://www.hal.inserm.fr/inserm-01407222/file/2016%2C%20Dufit%20et%20al.pdf

Éditeur(s) : HAL CCSD
Résumé : 32 pages
Wind energy production is very sensitive to instantaneous wind speed fluctuations. Thus rapid variation of wind speed due to changes in the local meteorological conditions can lead to electrical power variations of the order of the nominal power output. In small grids, as they exist for example on some islands in the French West Indies, such fluctuations can cause instabilities in case of intermediate power shortages. To palliate these difficulties, it is essential to identify and characterize the wind speed distributions. This allows to anticipate the eventuality of power shortage or power surge. Therefore, it is of interest to categorize wind speed fluctuations into distinct classes and to estimate the probability of a distribution to belong to a class. This paper presents a method for classifying wind speed histograms by estimating a finite mixture of Dirichlet distributions. The SAEM algorithm that we use provides a fine distinction between wind speed distribution classes. It's a new nonparametric method for wind speed sequences classification. However, we show that the wind speed distributions in each class correspond to specific Gram- Charlier densities.
https://hal.archives-ouvertes.fr/hal-00319608

hal-00319608
https://hal.archives-ouvertes.fr/hal-00319608
https://hal.archives-ouvertes.fr/hal-00319608v2/document
https://hal.archives-ouvertes.fr/hal-00319608/file/Article_dirichlet.pdf
ARXIV : 0810.4422

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
During the treatment process of drinking water, disinfectants (chlorine, ozone, chlorine dioxide) react on water containing organic matter and bromide to produce disinfection by-products at trace levels. Among them, five of the nine existing halo-acetic acids (HAAs) are commonly found in drinking water (monochloroacetic acid (MCAA), dichloroacetic acid (DCAA), monobromoacetic acid (MBAA), dibromoacetic acid (DBAA), and Trichloroacetic acid (TCAA)), including four classified in the 2B IARC group of potential carcinogens (BCAA, DBAA, DCAA, TCAA). With respect to drinking water quality, guidelines are proposed by WHO (2006) and water quality standards are imposed in many countries such as less than 100 μg/L for the sum of the five HAAs by US EPA (1998) and Canadian Health Department (2008). For this purpose, two analytical methods are commonly used, GC/MS with derivatization and LC/MS, UV or conductivity. A new method, based on two-dimensional ion chromatography (IC 2D) with suppressed conductivity is proposed. This method presents the main advantage of offering a quick implementation compared to GC or LC methods: direct injection, slight maintenance, lower cost of investment, by leading to good performances (specificity and sensitivity). The use of two different selectivity columns, and the fractionation on the first dimension canceling interferences, improves the specificity. The sensitivity is enabled by interfacing a preconcentration column between the two different internal diameter columns. The analytical conditions are optimized for the analysis of nine HAAs. The performances of the method are evaluated. The optimized method applied to natural water samples demonstrates its ability to quantify HAAs at trace levels in drinking water.
Microchemical Journal

hal-00877151
https://hal-univ-rennes1.archives-ouvertes.fr/hal-00877151
https://hal-univ-rennes1.archives-ouvertes.fr/hal-00877151/document
DOI : 10.1016/j.microc.2013.07.012

Éditeur(s) : HAL CCSD
Résumé : International audience
Half away between edge detection and object recognition this study aim to characterize singularities in order to guide this two phases. The caracterization is obtained with a generalization of the Lipschitz exponents .for complex structures. This new characterization is called " maxima chain " and integrates the notion of value and spatial repartition of the maxima. The maxima chains are obtained with a multiscale decomposition using a Diadic Discrete Wavelet Transform (DDWT). We use the maxima of the gradient image computed with the wavelet details. The local maxima detect the position of irregular structures (edges) in the image (Canny algorithm). Then we characterize each maxima using their evolution across the different scales. A classification is made using the maxima chains. We integrate the classification to eliminate unwanted maxima (from noise or other objects) to drive the search of closed contours. In fact, there is a totally different signature from one maxima to another depending on the parameters of the objects : nature, shape, size, gray scale, texture, ...
RFIA Proceedings
Toulouse, France

hal-00602265
https://hal.archives-ouvertes.fr/hal-00602265

Éditeur(s) : HAL CCSD Elsevier
Résumé : Over the last decades distance-based methods have been introduced and then improved in the field of spatial economics to gauge the geographic concentration of activities. There is a growing literature on this theme including new tools, discussions on their specific properties and various applications. However, there is currently no typology of distance-based methods. This paper fills that gap. The proposed classification helps understand all the properties of distance-based methods and proves that they are variations on the same framework.
ISSN: 0166-0462

hal-01606265
https://hal.archives-ouvertes.fr/hal-01606265
DOI : 10.1016/j.regsciurbeco.2016.10.004
PRODINRA : 407314

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Numerous archeomagnetic studies have provided high quality data for both the direction and the intensity of the geomagnetic field, essentially in Europe for the last 10 millennia. In particular, Greece supplies a lot of archeological materials due to its impressive cultural heritage and volcanic activity, so that numerous data have been obtained from burnt clays or historical lava flows. The most recent Greek secular variation curves are available for the last 8 millennia for the intensity and the last 6 millennia for the direction. Nevertheless, the coverage still presents several gaps for periods older than 2500 BC. In an effort to complete the Greek curve and extend it to older times, we present the archeointensity results from three Neolithic settlements in Northern Greece. The samples are of two different natures: burnt structures from Avgi (5250 ± 150 BC) and Vasili (4800 ± 200 BC), as well as ceramics from Dikili Tash (4830 ± 80 BC) and Vasili (4750 ± 250 BC). The samples have been subjected to standard rock magnetic analyses in order to estimate the thermal stability and the domain state of the magnetic carriers before archeointensity measurements. Surprisingly, very few ceramic samples provided reliable archeointensities whereas samples from burnt structures presented a very good success rate. Complementary studies showed that a detailed examination of the matrix color, following archeological information and classification standards can be a decisive test for pre-selection of sherds. In spite of these unsuccessful measurements from ceramics, we obtained an intensity value of 73.5 ± 1.1 μT for Dikili Tash, a higher value than the other data obtained in the same area, during the same period. However we do not have evidences for a technical artefact during the experiment. The burnt structures yielded two reliable archeointensities of 36.1 ± 1.8 μT and 46.6 ± 3.4 μT for Avgi and Vasili, respectively. Finally, we achieved a new archeomagnetic dating for these sites by comparing these new archeointensity values, combined to the directional measurements already published, with the Bulgarian secular variation curve. These new results contribute to extend the Greek secular variation reference curve towards older periods.
ISSN: 0031-9201

hal-00805575
https://hal.archives-ouvertes.fr/hal-00805575
DOI : 10.1016/j.pepi.2012.10.011

Éditeur(s) : HAL CCSD Nature Publishing Group
Résumé : International audience
Androgen signaling, via the androgen receptor (AR), is crucial in mediating prostate cancer (PCa) initiation and progression. Identifying new downstream effectors of the androgens/AR pathway will allow a better understanding of these mechanisms and could reveal novel biomarkers and/or therapeutic agents to improve the rate of patient survival. We compared the microRNA expression profiles in androgen-sensitive LNCaP cells stimulated or not with 1 nM R1881 by performing a high-throughput reverse transcriptase-quantitative PCR and found that miR-135a was upregulated. After androgen stimulation, we showed that AR directly activates the transcription of miR-135a2 gene by binding to an androgen response element in the promoter region. Our findings identify miR-135a as a novel effector in androgens/AR signaling. Using xenograft experiments in chick embryos and adult male mice, we showed that miR-135a overexpression decreases in vivo invasion abilities of prostate PC-3 cells. Through in vitro wound-healing migration and invasion assays, we demonstrated that this effect is mediated through downregulating ROCK1 and ROCK2 expression, two genes that we characterized as miR-135a direct target genes. In human surgical samples from prostatectomy, we observed that miR-135a expression was lower in tumoral compared with paired adjacent normal tissues, mainly in tumors classified with a high Gleason score (⩾8). Moreover, miR-135a expression is lower in invasive tumors, showing extraprostatic extension, as compared with intraprostatic localized tumors. In tumor relative to normal glands, we also showed a more frequently higher ROCK1 protein expression determined using a semi-quantitative immunohistochemistry analysis. Therefore, in tumor cells, the lower miR-135a expression could lead to a higher ROCK1 protein expression, which could explain their invasion abilities. The highlighted relationship between miR-135a expression level and the degree of disease aggressiveness suggests that miR-135a may be considered as a prognostic marker in human PCa.Oncogene advance online publication, 28 July 2014; doi:10.1038/onc.2014.222.
ISSN: 0950-9232

hal-01063902
https://hal.archives-ouvertes.fr/hal-01063902
https://hal.archives-ouvertes.fr/hal-01063902/file/Androgen-regulated%20microRNA-135a.pdf
DOI : 10.1038/onc.2014.222
PUBMED : 25065599

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : International audience
Alveolar proteinosis (AP) is a rare disease characterized by alveolar accumulation of surfactant components, which impairs gas exchange. AP is classified into three groups: auto-immune AP defined by the presence of plasma autoantibodies anti-GM-CSF, the most frequent form (90 % of all AP); secondary AP, mainly occurring as a consequence of haematological diseases, or following on from toxic inhalation or infections, and genetic AP, which affects almost exclusively children. AP diagnosis is suspected where chest CT-scan demonstrates interstitial lung disease with a crazy paving aspect; and confirmed by bronchoalveolar lavage, which has a milky appearance and contains periodic acid Schiff positive proteinaceous alveolar deposits. The use of surgical lung biopsy to confirm AP is less frequent nowadays. In this context, positive antibodies against GM-CSF indicates an auto-immune etiology of the AP. Concerning management, whole lung lavage is the gold standard therapy. In refractory AP, new treatments are available such as subcutaneous or inhaled GM-CSF supplementation, or rituximab infusions. The clinical course is unpredictable. Spontaneous improvement or even cure can occur, and the 5-year actuarial survival is 95 %. The most frequent complications are infectious etiology.
La protéinose alvéolaire pulmonaire (PAP) est une maladie rare caractérisée par l’accumulation alvéolaire de composants du surfactant qui gêne les échanges gazeux. Les PAP sont séparées en trois groupes : les PAP auto-immunes caractérisées par la présence d’anticorps sériques anti-GM-CSF qui sont les plus fréquentes ; les PAP secondaires à une maladie sous-jacente, le plus souvent hématologique, mais aussi à l’inhalation de toxiques et à des infections ; enfin, les PAP d’origine génétique. Le diagnostic de PAP est évoqué sur le scanner thoracique avec une pneumopathie infiltrante diffuse ayant un aspect classique de crazy paving, puis confirmé par l’aspect laiteux du lavage bronchoalvéolaire, et la présence de matériel lipoprotéinacé PAS positif. La confirmation du diagnostic de PAP par biopsie pulmonaire chirurgicale est désormais rarement nécessaire. La positivité des anticorps sériques anti-GM-CSF signe le caractère auto-immun de la maladie. Le traitement de référence des PAP auto-immunes est le « grand lavage pulmonaire thérapeutique ». En cas de maladie réfractaire, d’autres traitements sont disponibles, tels que le GM-CSF en injection sous-cutanée ou en aérosol et le rituximab. L’évolution de la maladie est imprévisible. Une évolution spontanément favorable ou même une guérison spontanée peuvent survenir et la survie actuarielle à 5 ans est de 95 %. Les principales complications sont infectieuses.
ISSN: 0761-8425

hal-01085907
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01085907
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01085907/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01085907/file/Prot%C3%A9inose%20alv%C3%A9olaire%20pulmonaire_accepted.pdf
DOI : 10.1016/j.rmr.2014.08.009

Éditeur(s) : HAL CCSD
Résumé : International audience
Extract the features for a multi-touch gesture is difficult due to the complex temporal and motion relations between multiple trajectories. In this paper we present a new generic graph model to quantify the shape, temporal and motion information from multi-touch gesture. To make a comparison between graph, we also propose a specific graph matching method based on graph edit distance. Results prove that our graph model can be fruitfully used for multi-touch gesture pattern recognition purpose with the classifier of graph embedding and SVM.
17th Biennial Conference of the International Graphonomics Society
Pointe-à-Pitre, Guadeloupe

hal-01165768
https://hal.univ-antilles.fr/hal-01165768
https://hal.univ-antilles.fr/hal-01165768/document
https://hal.univ-antilles.fr/hal-01165768/file/IGS_2015_submission_6.pdf

Éditeur(s) : HAL CCSD IWA Publishing
Résumé : International audience
This study proposes a new approach for improving resource quality management, monitoring and treatment plant management, whatever the environmental and climatic stressors. First trend analysis of water quality at a river basin scale, based on historical water quality data and multivariate exploitation (principal component analysis, PCA), led to a classification of the monitoring stations with regard to the main pressures (land use, urbanization and hydroclimatic impacts). This method was applied to the Vilaine's watershed, the largest river basin in Brittany, western France, and one which is under agricultural and urban pressure. A complementary research using a UV index was proposed for the evaluation of spatial and temporal variations of water quality. This approach may be considered as a useful and relevant tool to quickly assess the variation of water quality and the main explanatory factors. It also points out monitoring stations under specific stressors considered as outliers regarding UV parameters. Finally, PCA and UV index give complementary results. PCA allows factors influencing drinking water resource to be highlighted and the UV index allows global water quality under specific times and impacts to be reflected.
Water Science and Technology: Water Supply

hal-00878159
https://hal.archives-ouvertes.fr/hal-00878159
DOI : 10.2166/ws.2012.047

Éditeur(s) : HAL CCSD
Résumé : This thesis has been conducted on a fractured crystalline basement located in Ploemeur (South of Brittany, France). The detailed study of this basement requires a good understanding of their internal structures, namely their intrinsic properties, flow mode, density and fractures distribution. This work is focused on the petrophysical characterization of the granitic formations. Physical properties were determined from downhole geophysical measurements and images, and petrophysical measurements with thin sections made for each mini-core in the laboratory. Fresh-altered schist and fresh-altered granite separated by a normal angle fault are the main lithology of the Ploemeur crystalline basement. The results showed that the petrophysical properties were function of both porosity variation and degree of alteration and that the pore-space topology was found to be porositydependent. This thesis introduces a new formula between electrical resistivity and porosity. In addition, the laboratory measurements of Ploemeur revealed that seismic wave velocity was a function not only of porosity, but also of the predominant pore type. In general, the pore aspect ratio inverted from velocity measurements were classified roughly into crack shape. In the Ploemeur crystalline basement, the downhole geophysical measurements and images were used to measure changes in physical and chemical properties in the borehole fluid and the bedrock surrounding the boreholes. The effective integration of different geophysical methods, hydrogeological tests and lithological description was the best way to characterize the fractures in the crystalline basement, and is critical for a suitable estimation of fluid circulation.
Le socle cristallin fracturé, situé à Ploemeur (Bretagne sud, France) est l'objet de ce travail de thèse. L'étude détaillée du socle nécessite une bonne compréhension de la structure interne, à savoir les propriétés intrinsèques, le mode d'écoulement, la densité et la distribution des fractures. Ce travail de thèse est consacré à la caractérisation pétrophysique des formations granitiques. Les propriétés physiques ont été déterminées à partir de l'interprétation des données de mesures de géophysique en forage, des images de paroi du puits et des mesures pétrophysiques réalisées sur carottes en laboratoire. Afin de replacer les mesures dans leur contexte lithologique, une lame mince a été analysée pour chaque mini-carotte. Les formations lithologiques rencontrées dans le socle cristallin de Ploemeur sont des schistes et granites sains et altérés, ces deux lithologies étant séparées par une zone de faille. Les résultats ont montré que les propriétés pétrophysiques des roches étaient fonction à la fois de la variation de la porosité et du degré d'altération des roches et que la topologie de l'espace poreux était fortement dépendante de la porosité. Cette thèse introduit une nouvelle formule entre la résistivité électrique et la porosité. De plus, les mesures en laboratoire sur les échantillons de Ploemeur révèlent que les vitesses sismiques ne sont pas seulement fonction de la quantité de porosité, mais aussi fonction de facteur de forme. Ce dernier a été calculé sur les échantillons du socle de Ploemeur à partir des vitesses acoustiques. Les résultats ont montré que la porosité est de forme fissurale. L'intégration des données issues des images optiques et acoustiques, des mesures de géophysique en forage, et de la description des carottes a permis d'étudier de façon détaillée la géologie et l'hydrodynamique du socle de Ploemeur. L'intégration effective de ces différentes méthodes avec les tests hydrogéologiques ressort comme la meilleure façon de caractériser les fractures et les circulations en eau dans le socle.
https://tel.archives-ouvertes.fr/tel-00444175

Droits : info:eu-repo/semantics/OpenAccess
tel-00444175
https://tel.archives-ouvertes.fr/tel-00444175
https://tel.archives-ouvertes.fr/tel-00444175/document
https://tel.archives-ouvertes.fr/tel-00444175/file/thesebelghoul.pdf