Éditeur(s) : HAL CCSD
Résumé : International audience
Primary cultures of hepatocytes are powerful models in studying the sequence of events that are necessary for cell progression from a G0-like state to S phase. The models mimic the physiological process of hepatic regeneration after liver injury or partial hepatectomy. Many reports suggest that the mitogen-activated protein kinase (MAPK) ERK1/2 can support hepatocyte proliferation in vitro and in vivo and the MEK/ERK cascade acts as an essential element in hepatocyte responses induced by the EGF. Moreover, its disregulation has been associated with the promotion of tumor cell growth of a variety of tumors, including hepatocellular carcinoma. Whereas the strict specificity of action of ERK1 and ERK2 is still debated, the MAPKs may have specific biological functions under certain contexts and according to the differentiation status of the cells, notably hepatocytes. In this paper, we will focus on MEK1/2-ERK1/2 activations and roles in normal rodent hepatocytes in vitro and in vivo after partial hepatectomy and in human hepatocarcinoma cells. The possible specificity of ERK1 and ERK2 in normal and transformed hepatocyte will be discussed in regard to other differentiated and undifferentiated cellular models.
International Journal of Hepatology

Droits : info:eu-repo/semantics/OpenAccess
hal-00875664
https://hal.archives-ouvertes.fr/hal-00875664
https://hal.archives-ouvertes.fr/hal-00875664/document
https://hal.archives-ouvertes.fr/hal-00875664/file/TheMAPKMEK12-accepted.pdf
DOI : 10.1155/2012/328372

Résumé : Ce document présente comment saisir les métadonnées, compatibles à la norme ISO 19115 et à la Directive européenne INSPIRE, dans le serveur de données géographiques Sextant. L'approche de ce guide se veut pragmatique c'est-à-dire que la présentation des différents éléments se fait selon leur apparition dans l'ordre des onglets au niveau de la Vue avancée.

Droits : 2011 Ifremer
http://archimer.ifremer.fr/doc/00054/16516/14038.pdf
http://archimer.ifremer.fr/doc/00054/16516/

Éditeur(s) : Edp Sciences S A
Résumé : Reared sea bass were submitted to six stressful situations: hyperoxia with or without hypercapnia, increased stocking density in an open flow or recirculating system, transfer to another tank and nodavirus injection. The potentially negative impact of these factors on the lives of sea bass was investigated by measuring 9 water parameters and 19 fish parameters including total serum protein (TSP). TSP has already been used to evaluate stress. The present study investigates data of previous and new experiments, concentrating on the potential use of TSP as a routine indicator to assess welfare in sea bass reared on fish farms. In the current experiment, oxygen and carbon dioxide were seen to affect levels of TSP, but alterations were too erratic to enable proper comparison, probably because they are normal components of the fish environment and become toxic only by dose increase. TSP decreased when stocking density increased. After transfer to another tank, TSP decreased to 14% for three weeks and then increased during the fourth week through compensative overproduction, before returning to normal levels after 2 months. The results confirmed that transfer is an important stress factor for fish, with cumulative effects for successive transfers. TSP alteration of nodavirus-injected fish depends on the type of symptoms, which can be divided into 3 groups: (i) dying fish, in which TSP increased sharply due to over-production of protein involved in non-specific defences and inflammation, then decreased dramatically before death; (ii) whirling fish, a group that included both fish that later died, in which TSP decreased, and fish that subsequently survived, in which TSP increased due to development of specific immunity; and (iii) asymptomatic fish, in which TPS was similar to control levels and which were probably insensitive to nodavirus and/or had developed defences. In this paper, different mechanisms of TSP alteration are proposed and the interest of TSP as a field parameter is discussed. TSP is a non-destructive parameter that is robust, easy to measure everywhere and cheap, representing a suitable way of monitoring the overall welfare of fish by its regular increase. It can be used only as a "warning" of poor rearing conditions, however, and further investigations would be needed to identify the specific stress or health disorder.
Aquatic Living Resources (0990-7440) (Edp Sciences S A), 2011-04 , Vol. 24 , N. 2 , P. 121-127

Droits : EDP Sciences, IFREMER, IRD 2011
http://archimer.ifremer.fr/doc/00043/15382/12740.pdf
DOI:10.1051/alr/2011130
http://archimer.ifremer.fr/doc/00043/15382/

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
We investigate the timing of end of motion along the South Tibet Detachment System (STDS), a major normal fault system that runs parallel to the Himalayan range for more than 1500 km. Near Dinggye (similar to 28 degrees 10'N, 87 degrees 40'E), the STD dips similar to 10 +/- 5 degrees to the North and separates Paleozoic Tethyan series from Upper Himalayan Crystalline Series (UHCS). Immediately below the STD, the UHCS is highly deformed in the STD shear zone, lineations trend NNE and the shear senses are top to the NE. In micaschist, the P-T path constrained by pseudosection and garnet chemistry, shows successive metamorphic conditions of similar to 0.6 GPa and similar to 550 degrees C and 0.5 GPa and 625 degrees C. U/Pb dating of monazites and zircons in deformed and undeformed leucogranites suggests that ductile deformation lasted until at least similar to 16 Ma but ended prior to similar to 15 Ma in the STD shear zone similar to 100 m below the detachment. Ar/Ar micas ages in the footwall span between similar to 14.6 and 13.6 Ma, indicating rapid cooling down to similar to 320 degrees C, and suggesting persistence of normal faulting, at that time. The STDS is cut and offset by the N-S trending Dinggye active normal fault which initiated prior to 11 Ma thus providing a minimum bound for the end of STDS motion. These data are interpreted as reflecting 0.3 GPa (11 km) to 0.6 GPa (22 km) of exhumation along the STDS starting prior to similar to 16 Ma, ending between 13.6 and 11 Ma. The 1000 km long stretch of the STDS east of the Gurla Mandata probably stopped almost synchronously between 13 and 11 Ma ago, coevally with a sudden switch from NNE-SSW to E-W extension at the top of the accretionary prism, with a jump of the major thrust from the lower Main Central Thrust (MCTI) to the Main Boundary Thrust (MBT), and with a change in the India and Asia convergence direction. This synchronism is probably better explained in the frame of a thrust wedge or thrust system model than a lower channel flow model. West of the Gurla Mandata the STDS appears to stop 5 to 3 Ma earlier, possibly related to local interactions with the Karakorum fault in a way that needs to be understood.
ISSN: 0012-821X

hal-00475652
https://hal.archives-ouvertes.fr/hal-00475652
DOI : 10.1016/j.epsl.2009.12.035

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The South Liaodong Peninsula massif is the easternmost Mesozoic Metamorphic Core Complex, recognized in Eastern China. It provides a good example of the combination of ductile shearing, synkinematic plutonism and polyphase exhumation. The Jurassic granodioritic plutons, located at the footwall of the detachment normal fault, and dated here at ca 160 Ma, recorded two different phases of cooling. A slow cooling regime of about 3-10°C/my prevailing before 122 Ma, was followed by a significant increase in cooling rate of about 40-55°C/my after that time. By contrast, a single fast cooling path was recorded by the Cretaceous monzogranite situated in the footwall of the detachment normal fault. This result indicates that the Jurassic and Cretaceous plutons recorded different exhumation processes: a Jurassic slow or negligible exhumation and a Cretaceous fast one assisted by normal faulting. These two cooling stages correspond to distinct geodynamic processes during the Jurassic and Cretaceous. Extensional tectonics seems not significant before Early Cretaceous. The second stage, dominated by an extensional regime which develops after ca 120 Ma, is tentatively correlated to the lithosphere removal of the North China Craton.
ISSN: 1367-9120

Droits : http://creativecommons.org/licenses/by-nc-nd/
insu-00528171
https://hal-insu.archives-ouvertes.fr/insu-00528171
https://hal-insu.archives-ouvertes.fr/insu-00528171/document
https://hal-insu.archives-ouvertes.fr/insu-00528171/file/Lin-JAsianEarthSciences-2010.pdf
DOI : 10.1016/j.jseaes.2010.09.007

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The timing of E–W extension of the Tibetan plateau provides a test of mechanical models of the geodynamic evolution of the India–Asia convergence zone. In this work we focus on the Kung Co half graben (Southern Tibet, China), bounded by an active N–S normal fault with a minimum vertical offset of 1600 m. To estimate the onset of normal faulting we combined high and medium temperature (U–Pb, Ar/Ar) and low temperature ((U–Th)/He) thermochronometry of the Kung Co pluton, a two-mica granite of the northern Himalayan granitic belt that outcrop in the footwall of the fault. Biotite and muscovite Ar/Ar ages , are close from each other [not, vert, similar 16 Ma ± 0.2 (Ms) and not, vert, similar 15 ± 0.4 Ma (Bt)], which is typical of fast cooling. The zircon and apatite (U–Th)/He ages range from 11.3 to 9.6 Ma and 9.9 to 3.7 Ma respectively. These He ages are indicative of (1) fast initial cooling, from 11.3 to not, vert, similar 9 Ma, gradually decreasing with time and (2) a high geothermal gradient (not, vert, similar 400 °C/km), close to the surface at not, vert, similar 10 Ma. The Kung Co pluton was emplaced at about 22 Ma (U–Pb on zircon) at less than 10 km depth and 520–545 °C. Subsequent to its shallow emplacement, the pluton underwent fast thermal re-equilibration ending around 7.5 Ma, followed by a period of slow cooling caused either by the end of the thermal re-equilibration or by very slow exhumation (0.02–0.03 mm/yr) from not, vert, similar 7.5 Ma to at least 4 Ma. In either case the data suggest that the exhumation rate increased after 4 Ma. We infer this increase to be related to the initiation of the Kung Co normal fault. A critical examination of previously published data show that most not, vert, similar N–S Tibetan normal faults may have formed less than 5 Ma ago rather than in the Miocene as assumed by several authors. Such a young age implies that E–W extension is not related to the Neogene South Tibetan magmatism (25 to 8 Ma). Consequently, models relating E–W extension to magmatism, such as convective removal of the lower lithosphere, may be inappropriate. We rather think that this extension is related with local accommodation of boundary forces and displacements.
ISSN: 0012-821X

hal-00311791
https://hal.archives-ouvertes.fr/hal-00311791
DOI : 10.1016/j.epsl.2007.01.029

Éditeur(s) : Université des Antilles Études caribéennes
Résumé : El desbordamiento ocasionado por el modelo desarrollista de nuestra economía dio lugar a que el gobierno canario promoviera el Decreto (4/2001) para formular las Directrices de Ordenación General y del Turismo por entender que el territorio y los recursos naturales, en general, y la actividad turística, en particular, precisaban de una acción que articulase la orientación del desarrollo insular hacia un modelo sostenible. Se acompañó esa intervención con una serie de medidas cautelares tendentes a congelar el crecimiento y suspender el otorgamiento de licencias para la creación de nuevos establecimientos turísticos alojativos. Poco después, el ejecutivo canario emitió el Decreto 126/2001 para contener el crecimiento, y, finalmente, el Parlamento aprueba y pone en vigor la Ley de Medidas Urgentes en Materia de Ordenación del Territorio y del Turismo de Canarias (julio, 2001) para regular las condiciones que deben reunir los establecimientos de la modalidad hotelera con la máxima categoría. Por último, los diputados regionales dan el visto bueno a la Ley 19/2003 de Directrices de Ordenación General y las Directrices de Ordenación del Turismo de Canarias.
Confronté à une surfréquentation touristique, le Gouvernement local des Îles Canaries a publié un Arrêt (4/2001) qui reformule les Orientations Générales du Territoire et du Tourisme. L’objectif est de s’entendre sur les bases d’un modèle de développement insulaire soutenable, en mettant l’accent sur la gestion des ressources naturelles en général et le tourisme plus particulièrement. Cet Arrêt a été accompagné de normes dont l’objectif est de limiter la construction de nouveaux bâtiments hôteliers. Peu après, le Gouvernement a publié l’Arrêt 126/2001 qui limitait le développement touristique. Le Parlement adopta un autre Arrêt, la «Ley de Medidas Urgentes en Materia de Ordenación del Territorio y del Turismo de Canarias » (juillet 2001) qui détermine les conditions exigées aux établissements hôteliers de plus haute catégorie. Le Parlement donne aussi son accord à l’Arrêt 19/2003, «Directrices de Ordenación General y Directrices de Ordenación del Turismo de Canarias ».
Faced with excesses tourism, the local government of the Canary Islands issued a judgement (4 / 2001), which reformulates General Guidelines of Territory and Tourism. The aim is to set up the basis of a model of sustainable island development, with emphasis on natural resource management in general and tourism in particular. This decision was accompanied by standards whose objective is to limit the construction of new buildings for hotels. Shortly thereafter, the Government issued the ruling 126/2001 which limited the development of tourism. Parliament adopted another decree, "Ley de Medidas Urgent en Materia de Ordenación del Territorio y del Turismo de Canarias" (July 2001) which determines the conditions required for hotels higher category. The Parliament also gives its agreement to stop 19/2003, "Directrices de Ordenación General y Directrices de Ordenación del Turismo de Canarias."
Canaries

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.1232
http://journals.openedition.org/etudescaribeennes/1232

Éditeur(s) : HAL CCSD Société géologique de France
Résumé : New-Caledonia island consists of an ultramafic nappe thrusted over a continental and arc-derived basement as the result of the closure of a back-arc basin during the upper Eocene. The morphology of New-Caledonia is mostly characterized by its elongated shape and rectilinear coastline. Indeed, the western and eastern edges of the island are delineated by N140 trending normal faults that are well imaged on seismic lines. Major tectonic lineaments onland, including the scarps corresponding to the main boundary of the ultramafic nappe, also trend N140 suggesting a morphotectonic control by faults having similar kinematics (longitudinal flexure-fault of previous authors). We provide detailed observations from some of these scarps demonstrating indeed that these are not erosional features in origin. We explore the possibility that such surfaces do represent major tectonic limits that accommodated extension and significant tectonic thinning of both the peridotite nappe and its basement. Remnants of a complex extensional fault zone, 200 m wide, are still preserved along the western scarp of the Mont Dore mountain, close to Noumea city. The deformed zone is composed of an early shallow dipping detachment fault, some decimeters thick, offset by a group of late high angle normal faults and is bounded by cataclastic breccias that progressively pass into the fractured host peridotite. The late high angle fault zones have been the site of important syn-tectonic fluid circulation and are underlined by cm-thick silica infills bearing vertical striae. Typical morphology of the main scarps with break of slope is related to the combination of high angle normal faults and low angle detachment. Similar shallow dipping detachment surfaces have been observed along the east coast of southern New-Caledonia as well as within the ultramafic nappe itself and its basement. This study confirms that N140 oriented, large fault zones, with pure-normal to transtensional component of displacement, controlled the morphotectonic evolution of New-Caledonia at the regional scale, after the obduction of ophiolite nappe at the end of the Eocene. Such a fact has to be taken into account when attempting to reconstruct the post-obduction evolution of the island and more particularly when considering the development and distribution of the Ni-rich lateritic surfaces.
EISSN: 1777-5817

hal-00411855
https://hal.archives-ouvertes.fr/hal-00411855
DOI : 10.2113/gssgfbull.179.3.315

Éditeur(s) : HAL CCSD Société Géologique de France
Résumé : International audience
The seaward extension of onshore formations and structures were previously almost unknown in Provence. The interpretation of 2D high-resolution marine seismic profiles together with the integration of sea-bottom rock samples provides new insights into the stratigraphic, structural and paleogeographic framework of pre-Messinian Salinity Crisis (MSC) deposits of the Provence continental shelf. Seven post-Jurassic seismic units have been identified on seismic profiles, mapped throughout the offshore Provence area and correlated with the onshore series. The studied marine surface and sub-surface database provided new insights into the mid and late Cretaceous paleogeography and structural framework as well as into the syn-and post-rift deformation in Provence. Thick (up to 2000 m) Aptian-Albian series whose deposition is controlled by E-W-trending faults are evidenced offshore. The occurrence and location of the Upper Cretaceous South-Provence basin is confirmed by the thick (up to 1500 m) basinal series downlaping the Aptian-Albian unit. This basin was fed in terrigenous sediments by a southern massif (" Massif Méridional ") whose present-day relict is the Paleozoic basement and its sedimentary cover from the Sicié imbricate. In the bay of Marseille, thick syn-rift (Rupelian to Aquitanian) deposition occurred (>1000 m). During the rifting phase, syn-sedimentary deformations consist of dominant N040 to N060 sub-vertical faults with a normal component and N050 drag-synclines and anticlines. The syn-rift and early post-rift units (Rupelian to early Burdigalian) are deformed and form a set of E-W-trending en echelon folds that may result from sinistral strike-slip reactivation of N040 to N060 normal faults during a N-S com-pressive phase of early-to-mid Burdigalian age (18-20 Ma). Finally, minor fault reactivation and local folding affect post-rift deposits within a N160-trending corridor localized south of La Couronne, and could result from a later, post-Burdigalian and pre-Pliocene compressive phase.
Cadre tectonostratigraphique des formations anté-pliocènes du plateau continental de Provence (golfe du Lion oriental, SE France) Mots-clés. – Géologie marine, Tectonostratigraphie, Stratigraphie sismique, Paléogéographie crétacée, Rifting oligo-miocène, Compression post-rift Résumé. – Le prolongement en mer des formations et des structures provençales était jusqu'alors largement inconnu.L'interprétation de profils de sismique-réflexion marine 2D et l'intégration de dragages et carottages du fond-marin ont permis d'apporter des éléments nouveaux concernant le cadre stratigraphique, structural et paléogéographique des dé-pôts anté-Messiniens du plateau continental de Provence. Sept unités sismiques post-jurassiques ont été identifiées sur les profils sismiques, cartographiées à travers le plateau continental et corrélées avec les séries affleurant à terre. Une épaisse unité apto-albienne (jusqu'à 2000 m) dont le dépôt est contrôlé par des failles E-W a été mise en évidence en mer. L'existence d'un bassin subsident au Crétacé supérieur sur le plateau continental de Provence a été confirmée par le développement d'une épaisse série de bassin (jusqu'à 1500 m) reposant en downlap sur l'Apto-Albien. Le socle mé-tamorphique de l'écaille de Sicié et sa couverture sédimentaire peut être considéré comme une relique allochtone du « Massif Méridional » ayant alimenté le Bassin sud-provençal en éléments terrigènes au Crétacé supérieur. Dans la rade de Marseille, une épaisse unité syn-rift (Rupélien à Aquitanien) a été mise en évidence (>1000 m), structurée en une série de synformes en échelon d'axe E-W et affectée par des failles d'orientation dominante N040 à N060. Sur le flanc sud des synformes, la formation de plis d'axe N050 est associée à une déformation syn-sédimentaire. La formation des synformes en échelon d'axe E-W résulterait d'une réactivation en décrochement des failles N040 à N060 pendant une phase de compression N-S dont l'âge est compris entre le Burdigalien inférieur et moyen (18-20 Ma). Enfin, les dépôts post-rift sont affectés par des déformations mineures (réactivation de failles et plis associés), le long d'un couloir d'orientation N160 à l'ouest de la baie de Marseille, attribuables à une phase de compression post-burdigalienne et anté-pliocène.
ISSN: 0037-9409

hal-01463727
https://hal-amu.archives-ouvertes.fr/hal-01463727
https://hal-amu.archives-ouvertes.fr/hal-01463727/document
https://hal-amu.archives-ouvertes.fr/hal-01463727/file/Fournier_et_al_Provence_2016.pdf
DOI : 10.2113/gssgfbull.187.4-5.187

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
BACKGROUND:In French Guiana, cervical cancer is the second most frequent cancer in females. The objective of the present study was to describe the prevalence of HPV infections in women with normal cervical cytology living in the remote villages of French Guiana.METHODS:Before the study, the study team communicated in the remote villages on the importance of screening. All women from the target population were offered to participate. They signed informed consent during inclusion and then had a concomitant HPV-test and cervical smear. Only women with normal cytology and a good quality smear were analyzed. The detection of HPV-DNA was performed using the GREINER-BIO-ONE kit.RESULTS:Overall, 27.2% of women with normal cervical cytology had a positive HPV-test. There was a U-shaped evolution of prevalence with women over 50 years having the highest HPV prevalence, followed by the 20 to 29 years group. The most prevalent HPV genotypes were HPV 53(3.52%), 68(3.33%), 52(2.59%), 31(2.22%) and 16 (1.85%). The proportion of HPV 16 among HPV-infected women was 6.8%.CONCLUSIONS:HPV prevalence in cytologically normal women was very high. The most prevalent genotypes were very different from what is usually described in the world, and notably in South America.
ISSN: 1471-2458

pasteur-01583545
https://hal-riip.archives-ouvertes.fr/pasteur-01583545
https://hal-riip.archives-ouvertes.fr/pasteur-01583545/document
https://hal-riip.archives-ouvertes.fr/pasteur-01583545/file/2017%20Adenis%20et%20al.BMC%20Public%20Health.pdf
DOI : 10.1056/NEJMoa0808516

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
Glioblastoma (GB) is the most frequent and aggressive type of primary brain tumor. Recurrences are mostly located at the margin of the resection cavity in the peritumoral brain zone (PBZ). Although it is widely believed that infiltrative tumor cells in this zone are responsible for GB recurrence, few studies have examined this zone. In this study, we analyzed PBZ left after surgery with a variety of techniques including radiology, histopathology, flow cytometry, genomic, transcriptomic, proteomic, and primary cell cultures. The resulting PBZ profiles were compared with those of the GB tumor zone and normal brain samples to identify characteristics specific to the PBZ. We found that tumor cell infiltration detected by standard histological analysis was present in almost one third of PBZ taken from an area that was considered normal both on standard MRI and by the neurosurgeon under an operating microscope. The panel of techniques used in this study show that the PBZ, similar to the tumor zone itself, is characterized by substantial inter-patient heterogeneity, which makes it difficult to identify representative markers. Nevertheless, we identified specific alterations in the PBZ such as the presence of selected tumor clones and stromal cells with tumorigenic and angiogenic properties. The study of GB-PBZ is a growing field of interest and this region needs to be characterized further. This will facilitate the development of new, targeted therapies for patients with GB and the development of approaches to refine the per-operative evaluation of the PBZ to optimize the surgical resection of the tumor.
ISSN: 0167-594X

hal-01117083
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01117083
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01117083/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01117083/file/Characterizing%20the%20Peritumoral%20Brain%20Zone_accepted.pdf
DOI : 10.1007/s11060-014-1695-8

Résumé : Three unburied ocean bottom seismometers (OBS) equipped with Trillium 240 s broad-band seismometers recorded spheroidal free oscillations of the Earth out to periods over 1000 s period, for the M = 8.1, April 1, 2007 Solomon Islands earthquake. In contrast to broadband observatories of the global network that operate in quiet continental locations, these instruments were dropped on the several-km thick layer of sediments of the forearc and accretionary wedge of the Lesser Antilles subduction zone. Furthermore, a high ambient noise level due to the ocean surface infragravity waves is expected to cover the frequency band of Earth's normal modes band when recorded at these sites. In spite of these hostile environmental conditions, the frequency of clearly defined peaks of the Earth's normal modes were measured after the earthquake. This suggests that the recording of normal modes and long period waves can be extended to parts of the hitherto inaccessible ocean with currently available OBS technology.
Geophysical Research Letters (0094-8276), 2011-12 , Vol. 38 , N. 24 , P. L24305

Droits : 2011 by the American Geophysical Union
http://archimer.ifremer.fr/doc/00185/29606/27971.pdf
DOI:10.1029/2011GL049533
http://archimer.ifremer.fr/doc/00185/29606/

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
In Western Mediterranean, the Rif belt in Morocco is part of the Gibraltar Arc built during the Tertiary in the framework of Eurasia-Africa convergence. The structural and metamorphic evolution of the internal units of this belt as well as their timing, crucial to constrain the geodynamic evolution of the Alboran Sea, is still largely debated.Our study on the Ceuta Peninsula (Northern Rif) provides new structural, petrological and geochronological data (U-Th-Pb, Ar-Ar), which allow to precise the tectono-metamorphic evolution of the Lower Sebtides metamorphic units with:(1) a syn-metamorphic thrusting event developed under granulite facies conditions (7–10 kbar and 780–820 °C). A major thrust zone, the Ceuta Shear Zone, drove the emplacement of metapelites and peridotitic lenses from the Ceuta Upper Unit over the orthogneisses of the Monte Hacho Lower Unit. This compressional event ended during the Upper Oligocene.(2) an extensional event developed at the boundary between amphibolite and greenschist facies conditions (400–550 °C and 1–3 kbar). During this event, the Ceuta Shear Zone has been reactivated as a normal fault. Normal ductile shear zones contributed to the final exhumation of the metamorphic units during the Early Miocene.We propose that the compressional event is related to the formation of an orogenic wedge located in the upper plate, in a backward position, of the subduction zone driving the geodynamic evolution of the Alboran domain. In this context, the episode of lithospheric thinning could be related to the opening of the Alboran basin in a back-arc position.Furthermore, unlike the previous models proposed for the Rif belt, the tectonic coupling between mantle peridotites and crustal metamorphic rocks occurred in Ceuta Peninsula at a depth of 20–30 km under high temperature conditions, before the extensional event, and thus cannot be related to the back-arc extension.
ISSN: 0040-1951

insu-01682810
https://hal-insu.archives-ouvertes.fr/insu-01682810
DOI : 10.1016/j.tecto.2017.11.028

Éditeur(s) : HAL CCSD American Geophysical Union (AGU)
Résumé : International audience
The Ama Drime range located at the transition between the high Himalayan range and south Tibet is a N-S active horst that offsets the South Tibetan Detachment System (STDS). Within the horst, a paragneissic unit, possibly attributed to the upper Himalayan crystalline series, overly the lower Himalayan crystalline series Ama Drime orthogneissic unit containing large metabasite layers and pods that have experienced pressure >= 1.4 GPa. Combining structural analysis with new and published pressure-temperature (P-T) estimates as well as U-Th/Pb, Ar-39/Ar-40 and (U-Th)/He ages, the P-T-deformation-time (P-T-D-t) paths of the main units within and on both sides of the horst are reconstructed. They imply that N-S normal faults initiated prior to 11 Ma and have accounted for a total exhumation <= 0.6 GPa (22 km) that probably occurred in two phases: the first one until similar to 9 Ma and the second one since 6 to 4 Ma at a rate of similar to 1 mm/yr. In the Ama Drime unit, 1 to 1.3 GPa (37 to 48 km) of exhumation occurred after partial melting since similar to 30 Ma until similar to 13 Ma, above the Main Central Trust (MCT) and below the STDS when these two fault systems were active together. The switch from E-W (STDS) to N-S (Ama Drime horst) normal faulting between 13 and 12 Ma occurs at the time of propagation of thrusting from the MCT to the Main Boundary Thrust. These data are in favor of a wedge extrusion or thrust system rather than a crustal flow model for the building of the Himalaya. We propose that the kinematics of south Tibet Cenozoic extension phases is fundamentally driven by the direction and rate of India underthrusting.
ISSN: 0278-7407

hal-00486405
https://hal.archives-ouvertes.fr/hal-00486405
DOI : 10.1029/2009TC002551

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The non-classical human leukocyte antigen-G, HLA-G, plays an important role in inducing tolerance, through its immunosuppressive effects on all types of immune cells. Immune tolerance is a key issue in the liver, both in liver homeostasis and in the response to liver injury or cancer. It would therefore appear likely that HLA-G plays an important role in liver diseases. Indeed, this molecule was recently shown to be produced by mast cells in the livers of patients infected with hepatitis C virus (HCV). Furthermore, the number of HLA-G-positive mast cells was significantly associated with fibrosis progression. The generation of immune tolerance is a role common to both HLA-G, as a molecule, and the liver, as an organ. This review provides a summary of the evidence implicating HLA-G in liver diseases. In the normal liver, HLA-G transcripts can be detected, but there is no HLA-G protein. However, HLA-G protein is detectable in the liver tissues and/or plasma of patients suffering from hepatocellular carcinoma, hepatitis B or C, or visceral leishmaniasis and in liver transplant recipients. The cells responsible for producing HLA-G differ between diseases. HLA-G expression is probably induced by microenvironmental factors, such as cytokines. The expression of HLA-G receptors, such as ILT2, ILT4, and KIRD2L4, on liver cells has yet to be investigated, but these receptors have been detected on all types of immune cells, and such cells are present in liver. The tolerogenic properties of HLA-G explain its deleterious effects in cancers and its beneficial effects in transplantation. Given the key role of HLA-G in immune tolerance, new therapeutic agents targeting HLA-G could be tested for the treatment of these diseases in the future.
ISSN: 0168-8278

hal-01134468
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01134468
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01134468/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01134468/file/Biology%20of%20the%20immunomodulatory%20molecule%20HLA-G.pdf
DOI : 10.1016/j.jhep.2015.03.007

Éditeur(s) : Amer Geophysical Union
Résumé : The oblique convergence between North American and Caribbean plates is accommodated in a bookshelf faulting manner by active, oblique-normal faults in the northern part of the Lesser Antilles arc. In the last 20 years, two M > 6 earthquakes occurred along a large, arc parallel, en echelon fault system, the 16 March 1985 in Redonda and 21 November 2004 in Les Saintes. A better understanding of active faulting in this region permit us to review the location and magnitude of historical earthquakes by using a regional seismic attenuation law. Several others moderate earthquakes may have occurred along the en echelon fault system implying a strong seismic hazard along the arc. These faults control the effusion of volcanic products and some earthquakes seem to be correlated in time with volcanic unrest. Shallow earthquakes on intraplate faults induced normal stress and pressure changes around neighboring volcano and may have triggered volcanic activity. The Redonda earthquake could have initiated the 1995 eruption of Montserrat's Soufriere Hills by compressing its plumbing system. Conversely, pressure changes under the volcano increased Coulomb stress changes and brought some faults closer to failure, promoting seismicity. We also discuss the magnitude of the largest 11 January 1839 and 8 February 1843 megathrust interplate earthquakes. We calculate that they have increased the stress on some overriding intraplate faults and the extensional strain beneath several volcanoes. This may explain an increase of volcanic and seismic activity in the second half of the 19th century culminating with the devastating, 1902 Mount Pelee eruption.
Journal Of Geophysical Research-solid Earth (0148-0227) (Amer Geophysical Union), 2011-10 , Vol. 116 , N. B10308 , P. 1-26

Droits : Copyright 2011 by the American Geophysical Union
http://archimer.ifremer.fr/doc/00200/31097/29515.pdf
DOI:10.1029/2011JB008443
http://archimer.ifremer.fr/doc/00200/31097/

Éditeur(s) : HAL CCSD
Résumé : International audience
Trees can control their shape and resist gravity thanks to their ability to produce wood under tensile stress. This stress is known to be produced during the maturation of wood fibres but the mechanism of its generation remains unclear. This study focuses on the formation of the secondary wall in tension wood produced in artificially tilted poplar saplings. Thickness of secondary wall layer (SL) and gelatinous layer (GL) were measured from cambium to mature wood in several trees sampled at different times after tilting. Measurements on wood fibres produced before tilting show the progressive increase of secondary wall thickness during the growing season. After the tilting date, SL thickness decreased markedly from normal wood to tension wood while the total thickness increased compared to normal wood, with the development of a thick GL. However, even after GL formation, SL thickness continues to increase during the growing season. GL thickening was observed to be faster than SL thickening. The development of the unlignified GL is proposed to be a low cost, efficient strategy for a fast generation of tensile stress in broadleaved trees.
IAWA journal / International Association of Wood Anatomists.

hal-01229277
https://hal.archives-ouvertes.fr/hal-01229277
https://hal.archives-ouvertes.fr/hal-01229277/document
https://hal.archives-ouvertes.fr/hal-01229277/file/AbediniClair-Iawa-TensionCellWallThickening_preprint_HAL.pdf
DOI : 10.1163/22941932-00000084

Éditeur(s) : HAL CCSD
Résumé : When the upper crust below the mountain ranges shows crustal extension with a direction collinear to the convergence direction, it is generally accepted that it is the result of gravitational collapse. However, recent studies challenge this paradigm by showing that erosion induces uplift and extension in the central part of the low convergent mountain ranges. In this study, we investigate the impact of denudation on the seismotectonic regime of mountain ranges.In order to identify a relationship between seismotectonic regime and erosion, the first part of this work presents a compilation of data in the mountain ranges. Based on these observations, a simple kinematic model is proposed to predict the seismotectonic regime of the study ranges.For low convergence rate and moderate mean elevation ranges, this model predicts an extension regime when the denudation rate is 15% higher than the convergence rate.The second part is devoted to the development of thermomechanical 2D finite element models to study the impact of surface processes on the deformation of the Pyrenees. The results show that the isostatic response to erosion reactivates pre-existing structures. The kinematics of an inherited fault plane can be predicted due to the gradient of the horizontal surface velocity profile. Thus, a plane located in the eroded zone is reactivated in normal fault when near the border of the erosion area, this same plane is reactivated in reverse fault. These results suggest that the current deformation in the North Pyrenean Zone could be the result of surface processes.Given the small number of studies quantifying erosion rates in the Pyrenees, the models developed in the second part suffer from high uncertainty. To remedy this, we study the central Pyrenees through a study that combines two types of data : watershed denudation rates from cosmogenic isotopes concentration, and incision rates from sediments buried in the karst. These results are presented in chapter 3. Denudation profiles obtained are consistent with reactivation of a normal fault plane located in the North Zone of the Central Pyrenees.From our study in the Pyrenees, a good correlation appears between the value of the rate of erosion and the glacier occupation. Given that the glaciers where more developed in the Alps, it raises the question of the impact of the late-würmian deglaciation on the present deformation of this range. A numerical model detailing this relationship is presented in the fourth chapter. Theresults show that deglaciation of the western Alps is controlled by the rheological heterogeneity of the crust. Some of our models predict uplift rates consistent with those highlighted by geodesy.
Lorsque l’extension de la croûte sous les parties hautes des chaînes de montagnes est colinéaire à la direction de convergence, il est traditionnellement admis que le moteur est l’effondrement gravitaire. Pourtant, des études récentes remettent en cause ce paradigme en montrant que l’érosion induit un soulèvement et de l’extension dans la partie centrale des chaînes de montagne à faible taux de convergence. L’objectif de notre étude est d’étudier l’impact de la dénudation de la topographie sur le régime sismo-tectonique des chaînes de montagnes.La première partie de ce travail présente une compilation de données dans les chaînes de montagnes afin de dégager des relations entre régime sismo-tectonique et érosion. Sur la base de ces observations, un modèle cinématique simple permettant de prévoir le régime de la chaîne est proposé. Ainsi, pour les chaînes à faible taux de convergence et d’élévation moyenne, ce modèleprédit de l’extension lorsque le taux de dénudation est 15% plus élevé que le taux de convergence.La deuxième partie est consacrée au développement d’un modèle thermo-mécanique 2D en éléments finis pour étudier l’impact des processus de surface sur la déformation des Pyrénées.Les résultats montrent que la réponse isostatique à l’érosion permet de réactiver des structurespré-existantes. La cinématique d’un plan de faille hérité peut être prédite grâce au gradient du profil des vitesses de surface horizontales. Ainsi, un plan situé dans la zone d’érosion est réactivé en faille normale alors qu’en bordure de cette zone une faille est réactivée en régime inverse. Ces résultats suggèrent que la déformation actuelle des Pyrénées pourrait être la conséquence d’unprocessus d’érosion.Compte tenu du faible nombre d’études quantifiant les taux d’érosion dans les Pyrénées, les modèles développés dans la deuxième partie souffrent d’une forte incertitude. Pour y remédier, nous avons cherché à les quantifier dans les Pyrénées Centrales grâce à une étude qui combine deux types de données : taux de dénudation des bassins versants à partir des isotopes cosmogéniques, et vitesses d’incision à partir des sédiments piégés dans les karsts. Ces résultats sontprésentés dans la troisième partie. Les profils de dénudation obtenus sont compatibles avec unrejeu en faille normale d’un plan situé dans la Zone Nord Pyrénéenne des Pyrénées Centrales.Notre étude dans les Pyrénées, montre une bonne corrélation entre la valeur du taux d’érosion et la cartographie de l’occupation glaciaire. Les glaciers ayant été plus développés dans les Alpes, cela pose la question de l’impact de la déglaciation tardi-Wurmienne sur la déformation actuelle de cette chaîne. Un modèle numérique détaillant cette relation est présenté dans le quatrième chapitre. Les résultats montrent que la déglaciation des Alpes occidentales est contrôléepar l’hétérogénéité rhéologique de la croute. Certains de nos modèles prédisent des vitesses de surrection compatibles avec celles mises en évidence par la géodésie.
https://hal.archives-ouvertes.fr/tel-01262333

tel-01262333
https://hal.archives-ouvertes.fr/tel-01262333
https://hal.archives-ouvertes.fr/tel-01262333/document
https://hal.archives-ouvertes.fr/tel-01262333/file/these-Genti-2015-postjury.pdf

Éditeur(s) : Université des Antilles Études caribéennes
Résumé : Este trabajo indaga en la forma de componer la apariencia femenina hacia el inicio del siglo XX, como signo altamente valorado de un estilo de vida. Se hará hincapié en la moda para el ocio en la playa. En el marco de una práctica insipiente, se priorizó la necesidad de exaltar la distinción por sobre la vivencia de las sensaciones que podrían provocar el contacto con la naturaleza. Se entiende que para esto fueron decisivas las pautas tipológicas, tecnológicas y funcionales del vestir. Los atributos como forma, materialidad, modos de confección y de uso trascendieron su rol técnico para volverse condicionantes de las formas de comportamiento e interacción social y para comunicar los modos que podía asumir el gusto por el lujo.
Ce travail de recherche est consacré à la construction de l'apparence féminine, au début du xxe siècle, comme style de vie jouissant d’une grande considération. L’accent est mis sur le développement de la mode sur les plages, dans un cadre d’oisiveté. Dans le cadre de l’émergence de ces pratiques naïves, la priorité fut l’exaltation d’un besoin de distinction plutôt que la recherche de sensations au contact de la nature. De nouvelles normes émergent en combinant les types, les technologies et la fonctionnalité de l’habillement. Les attributs comme la forme, la matérialité, la confection et l’usage constituent des éléments déterminants dans les formes de comportement et les interactions sociales et ils illustrent les différentes manières d’assumer le goût du luxe.
This work investigates in the way of composing the feminine appearance to the beginning of the 20th century, as sign highly valued of a way of life. It will be emphasized in the mode used for the leisure in the beach. In the frame of an ignorant practice, there was prioritized the need to exalt the distinction for on the experience of the sensations that might provoke the contact with the nature. There is understood that for it were decisive the guidelines typological, technological and functional of to dress. The attributes like form, materiality, confection and use, came out his technical role to become determining of the forms of behavior and social interaction and to communicate the manners that the taste could assume for the luxury.

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.7348
http://journals.openedition.org/etudescaribeennes/7348

Éditeur(s) : HAL CCSD
Résumé : Today, one of the main challenges in the oil industry is the exploitation of new resources in naturally fractured reservoirs often located in structurally complex areas such as plate boundaries, mountain ranges or near salt structures. While numerical models of rock deformation based on continuum mechanics are becoming industry standard in providing efficient means for modelling natural fractures in reservoirs, the knowledge of past perturbed stress fields, which is referred as the type (normal, wrench or reverse), orientation and magnitude of the regional or local tectonic stresses that needs to be applied as boundary condition in numerical simulations, is often unknown or approximated.The essence of this thesis is to improve the recovery of the paleostress field needed to constrain numerical simulations. I first described and discuss through a comprehensive mechanically-based multi-parametric study how far we can rely on the commonly used paleostress inversion methods based on fault slip data and the Wallace and Bott assumptions. I then compared this method with a new generation technique based on geomechanics using field observations. Since slip markers on faults are hardly observed in core or image log, I used observed natural fracture data as main drivers for the inversion of the paleostress using geomechanically-based method. I demonstrated, through various outcrop and subsurface examples, how this can efficiently be done. Finally, I aimed at addressing the problem of polyphase fracture data sets with unknown mechanical type (joints, faults, stylolites ...) and expanded the mechanical stress inversion to the separation of tectonic phases.
Aujourd'hui, l'un des principaux défis dans l'industrie pétrolière est l'exploitation de nouvelles ressources dans les réservoirs naturellement fracturés souvent situés dans des zones structurellement complexes tels que les frontières de plaques, les chaînes de montagnes ou les structures de proches des dômes de sel. Alors que les modèles numériques de déformation des roches basée sur la mécanique des milieux continus fournissant des moyens efficaces pour la modélisation de fractures naturelles dans les réservoirs, sont devenus la norme dans l'industrie, les paléo-contraintes régionales ou locales appliquées comme condition aux limites dans les simulations numériques, définies par le régime (normal, décrochant ou inverse), l'orientation, et la magnitude des contraintes tectoniques, sont souvent inconnues ou approximées.L'essence de cette thèse est d'améliorer la prédiction du champ de paléo-contrainte nécessaire pour contraindre les simulations numériques. J’ai décrit dans un premier temps à travers une étude comparative multi-paramétrique complète basée sur la mécanique, dans quelle mesure nous pouvions compter sur les méthodes d'inversion des paléo-contraintes basées sur les hypothèses de Wallace et Bott et les données de glissement sur les failles. J’ai ensuite comparé ces méthodes avec une technique d’inversion de nouvelle génération basée sur la géomécanique en utilisant les observations de terrain. Puisque les marqueurs de glissement sur les failles sont rarement observés le long du forage, j’ai utilisé l’inversion géomécanique des contraintes pour les données de fractures naturelles observées. J’ai alors démontré, l’efficacité de cette technique à travers divers exemples d'affleurements et de subsurface. Enfin, j’ai proposé une solution afin de résoudre le problème des données de fractures polyphasées à type cinématique inconnu (joints, failles, stylolites ...) et étendu l’inversion de contrainte basée sur la géomécanique à la séparation des phases tectoniques.
https://hal.archives-ouvertes.fr/tel-01324110

tel-01324110
https://hal.archives-ouvertes.fr/tel-01324110
https://hal.archives-ouvertes.fr/tel-01324110/document
https://hal.archives-ouvertes.fr/tel-01324110/file/theselejri.pdf