Éditeur(s) : Taylor and Francis
Résumé : A new cumacean genus and species, Thalycrocuma sarradini gen. et sp. nov., belonging to the family Nannastacidae is described from several sites of the Lucky Strike hydrothermal vent field (Mid-Atlantic Ridge, 37N, 1700 m depth). The new genus differs from others in the family by males lacking exopods on the pereopods 3 and 4 and having an antenna with a five-articulate peduncle and a short flagellum. This is the first cumacean species that could be considered, at the moment, as endemic from hydrothermal vent areas. Data on the accompanying fauna including other cumacean species (Cyclaspis longicaudata, Bathycuma brevirostre, Procampylaspis sp. and Makrokylindrus sp.) and some ecological remarks are included. A key for the currently known genera of the family Nannastacidae is provided and the taxonomic position of some genera is discussed.
Marine Biology Research (1745-1000) (Taylor and Francis), 2008-06 , Vol. 4 , N. 3 , P. 180-192

Droits : 2008 Taylor & Francis Group
http://archimer.ifremer.fr/doc/2008/publication-4358.pdf
DOI:10.1080/17451000801898576
http://archimer.ifremer.fr/doc/00000/4358/

Éditeur(s) : Elsevier
Résumé : Sediment cores were collected from April to August 2004 on tidal mudflats of the macrotidal Marennes-Oléron Bay (SW France), famous for the cultivation of Pacific oysters (Crassostrea gigas). The response of living (stained) benthic foraminifera to short-term biogeochemical disturbances in the sediment and overlying water, which may be involved in oyster summer mortality, was monitored. Short-term hypoxia occurred in early June, in conjunction with a sudden rise in temperature. In mid-June, the ammonia content of sediment porewater increased, leading to potentially maximal flux towards overlying waters. Foraminiferal assemblages, particularly in the topmost layer, were altered. Ammonia tepida was the most tolerant to temperature increase and hypoxic conditions whereas Brizalina variabilis and Haynesina germanica were sensitive to organic degradation and hypoxia. Cribroelphidium gunteri was the most opportunistic during recolonisation. Benthic foraminifera showed that short-term biochemical changes in the sediment are toxic and may be involved in the summer mortality of Pacific oysters.
Marine Environmental Research (0141-1136) (Elsevier), 2007-09 , Vol. 64 , N. 3 , P. 358-383

Droits : 2007 Elsevier Ltd All rights reserved
http://archimer.ifremer.fr/doc/2007/publication-2586.pdf
DOI:10.1016/j.marenvres.2007.02.007
http://archimer.ifremer.fr/doc/00000/2586/

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Cnidarians living in symbiosis with photosynthetic dinoflagellates (commonly named zooxanthellae) are exposed to high concentrations of reactive oxygen species (ROS) upon illumination. To quench ROS production, both the cnidarian host and zooxanthellae express a full suite of antioxidant enzymes. Studying antioxidative balance is therefore crucial to understanding how symbiotic cnidarians cope with ROS production. We characterized glutathione peroxidases (GPx) in the symbiotic cnidarian Anemonia viridis by analysis of their isoform diversity, their activity distribution in the three cellular compartments (ectoderm, endoderm and zooxanthellae) and their involvement in the response to thermal stress. We identified a GPx repertoire through a phylogenetic analysis showing 7 GPx transcripts belonging to the A. viridis host and 4 GPx transcripts strongly related to Symbiodinium sp. The biochemical approach, used for the first time with a cnidarian species, allowed the identification of GPx activity in the three cellular compartments and in the animal mitochondrial fraction, and revealed a high GPx electrophoretic diversity. The symbiotic lifestyle of zooxanthellae requires more GPx activity and diversity than that of free-living species. Heat stress induced no modification of GPx activities. We highlight a high GPx diversity in A. viridis tissues by genomic and biochemical approaches. GPx activities represent an overall constitutive enzymatic pattern inherent to symbiotic lifestyle adaptation. This work allows the characterization of the GPx family in a symbiotic cnidarian and establishes a foundation for future studies of GPx in symbiotic cnidarians.
ISSN: 0300-9084

hal-01404424
http://hal.upmc.fr/hal-01404424
http://hal.upmc.fr/hal-01404424/document
http://hal.upmc.fr/hal-01404424/file/Pey_Characterization_of.pdf
DOI : 10.1016/j.biochi.2016.10.016

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
Prostate cancer disparities have been reported in men of African descent who show the highest incidence, mortality, compared with other ethnic groups. Few studies have explored the genetic and environmental factors for prostate cancer in men of African ancestry. The glutathione-S-transferases family conjugates carcinogens before their excretion and is expressed in prostate tissue. This study addressed the role of GSTM1 and GSTT1 deletions on prostate cancer risk in populations of African descent. This multi-institutional case-control study gathered data from the Genetic Susceptibility to Environmental Carcinogens (GSEC) database, the African-Caribbean Cancer Consortium (AC3) and Men of African Descent and Carcinoma of the Prostate Consortium (MADCaP). The analysis included 10 studies (1715 cases and 2363 controls), five in African-Americans, three in African-Caribbean and two in African men. Both the GSTM1 and the GSTT1 deletions showed significant inverse associations with prostate cancer [odds ratio (OR): 0.90, 95% confidence interval (CI) 0.83-0.97 and OR 0.88, 95% CI: 0.82-0.96, respectively]. The association was restricted to Caribbean and African populations. A significant positive association was observed between GSTM1 deletion and prostate cancer in smokers in African-American studies (OR: 1.28, 95% CI: 1.01-1.56), whereas a reduced risk was observed in never-smokers (OR: 0.66, 95% CI: 0.46-0.95). The risk of prostate cancer increased across quartiles of pack-years among subjects carrying the deletion of GSTM1 but not among subjects carrying a functional GSTM1. Gene-environment interaction between smoking and GSTM1 may be involved in the etiology of prostate cancer in populations of African descent.
ISSN: 0143-3334

hal-00682901
https://hal.archives-ouvertes.fr/hal-00682901
DOI : 10.1093/carcin/bgr119
PUBMED : 21705483

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
In contrast to mammals that have limited proliferation and neurogenesis capacities, the Xenopus frog exhibit a great potential regarding proliferation and production of new cells in the adult brain. This ability makes Xenopus a useful model for understanding the molecular programs required for adult neurogenesis. Transcriptional factors that control adult neurogenesis in vertebrate species undergoing widespread neurogenesis are unknown. NeuroD1 is a member of the family of proneural genes, which function during embryonic neurogenesis as a potent neuronal differentiation factor. Here, we study in detail the expression of NeuroD1 gene in the juvenile and adult Xenopus brains by in situ hybridization combined with immunodetections for proliferation markers (PCNA, BrdU) or in situ hybridizations for cell type markers (Vimentin, Sox2). We found NeuroD1 gene activity in many brain regions, including olfactory bulbs, pallial regions of cerebral hemispheres, preoptic area, habenula, hypothalamus, cerebellum and medulla oblongata. We also demonstrated by double staining NeuroD1/BrdU experiments, after long post-BrdU administration survival times, that NeuroD1 gene activity was turned on in new born neurons during post-metamorphic neurogenesis. Importantly, we provided evidence that NeuroD1-expressing cells at this brain developmental stage were post-mitotic (PCNA-) cells and not radial glial (Vimentin+) or progenitors (Sox2+) cells.
ISSN: 1932-6203

hal-00877023
https://hal-univ-rennes1.archives-ouvertes.fr/hal-00877023
https://hal-univ-rennes1.archives-ouvertes.fr/hal-00877023/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-00877023/file/The_Neurogenic_Factor-accepted.pdf
DOI : 10.1371/journal.pone.0066487

Éditeur(s) : Université de Montpellier II
Résumé : Penaeid family shrimp constitute the first aquaculture product in the world in terms of commercial value. They are produced in third world countries of the sub-equatorial belt. Among the causes limiting their production, one is the presence of the WSSV (White Spot Syndrome Virus), a pathogenic agent that produces massive mortality. Our aim was to investigate the first stages of the viral infection, in order to be used as target of prophylactic actions. A fish cell line (SSN-1) was used as model to tentatively develop in vitro studies. Only defective particles were produced confirming the high specificity to crustacea of the infection with crustacean virus. Electron microscopy showed structural similarities between the WSSV and B, B2 and Baculo-B viruses of crabs. This suggests B2 may belong also to the family Nimaviridae, genus Whispovirus. This comparison with B2 virus gives the possibility to understand the role played by the tail-like extension of these viruses in the infectious process by attachment to the plasmic membrane at the beginning of the infection in its specific host.
Les crevettes de grande taille de la famille des Penaeidae constituent le premier produit aquacole en valeur commerciale à l'échelle planétaire. Elles sont produites à 99% dans les pays en voie de développement de la ceinture sub-équatoriale. Parmi les causes limitant leur production, le White Spot Syndrome Virus est l'agent pathogène ayant provoqué le plus des pertes dans le monde. Notre étude a été orientée vers la reconnaissance des premiers stades de l'infection, susceptibles d'être la cible d'une action prophylactique. Nous avons testé l'utilisation d'une lignée cellulaire de poisson SSN-1 afin d'étudier les possibilités d'un développement in vitro. Seules des particules défectives ont été produites confirmant la haute spécificité des infections à virus de crustacés. Les recherches en microscopie électronique ont montré une similarité structurale du WSSV avec les virus (B, B2 et Baculo-B) des crabes. Ceci suggère que ces agents (B2 et WSSV) seraient tout deux de la famille des Nimaviridae et du genre Whispovirus. La comparaison avec le virus B2 permet de comprendre le rôle clef joué par la partie caudale de ces virus dans l'infection par son attachement à la membrane plasmique lors de l'infection chez son hôte spécifique.

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/2008/these-6650.pdf
http://archimer.ifremer.fr/doc/00000/6650/

Éditeur(s) : Société Française d'Ichtyologie
Résumé : In the present paper a new genus, Diretmoides, and a new species, Diretmoides parini, of the berycomorph family Diretmidae is described. The hitherto single genus of the family, Diretmus Johnson, 1863, therefore becomes monotypic while the new genus includes two species pauciradiatus (Woods, 1973) and parini sp. nov. The genus Diretmus is mainly charactcrized by three features (1) by its anus placed immediately anterior to the anal fin, (2) by a prepelvic ridge of ventral scutes and (3) by the high number of bony lamellae on the upper third of the operculum. The species of Diretmoides on the other hand have (1) their anus midway between the pelvics and the anal fin, (2) the ventral midline anterior to their pelvics is flat and is covered by normal body-scales and (3) there are only a few lamellae on the upper third of the operculum. Juveniles of the two Diretmoides-species differ from each other in their colour pattern,the adolescents and adults in meristic characters. All described species live meso-to bathypelagically. D. argenteus is widely distributed in tropical and temperate waters of all oceans. The two Diretmoides -species also live in the Atlantic as well as in the Pacific. However there is only one record of Diretmoides parini and none of D. pauciradiatus from the Indian Ocean. In addition to the described species, indication is given of the presumable existence of a third Diretmoides-species from off Japan. Artificial keys to adults and juveniJes are given at the end of this paper. NOT CONTROLLED OCR
Les auteurs décrivent un nouveau genre, Diretmoides, et une nouvelle espèce, Diretmoides parini. Le genre Diretmus ne comprend plus qu'une seule espèce D. argenteus Johnson, 1863; Diretmoides en comporte deux;D. pauciradiatus (Woods, 1973) d D. parini n.sp. Le genre Diretmus est caractérisé principalement par la position de l'anus juste en avant de l'anale par la présence en avant des pelviennes d'une carène épineuse ventrale et par la densité des lamelles osseuses sur le tiers supérieur de l'opercule. Chez Diretmoides l'anus est à mi-distance entre l'anale et les pelviennes; il n'y a pas de carène épineuse ventrale en avant des pelviennes et, sur le tiers supérieur de l'opercule, les lamelles osseuses sont peu nombreuses et éparses. Les jeunes Diretmoides se distinguent les uns des autres par leur coloration, les adolescents et les adultes par leurs caractères méristiques. Tous les Diretmidés actuellement connus sont des espèces méso à bathypélagiques. D. argenteus est largement distribué dans les eaux tropicales et tempérées de tous les océans. Les deux espèces de Diretmoides ont été signalées dans l'Atlantique et te Pacifique mais on ne connaît qu'une seule capture de D. parini dans l'océan indien et aucune de D. pauciradiatus. En outre. l'étude d'exemplaires provenant du Japon a amené les auteurs à souligner l'existence probable d'une troisième espèce de Diretmoides. Deux clés de détermination, l'une pour les adultes, l'autre pour les jeunes des trois espèces décrites, sont données à la fin de cette note. OCR NON CONTRÔLE
Cybium (Société Française d'Ichtyologie), 1981 , Vol. 5 , N. 1 , P. 33-60

Droits : 1981 Société Française d'Ichtyologie
http://archimer.ifremer.fr/doc/1981/publication-3746.pdf
http://archimer.ifremer.fr/doc/00000/3746/

Éditeur(s) : HAL CCSD European Geosciences Union
Résumé : Xylem density is a physical property of wood that varies between individuals, species and environments. It reflects the physiological strategies of trees that lead to growth, survival and reproduction. Measurements of branch xylem density, ρx, were made for 1653 trees representing 598 species, sampled from 87 sites across the Amazon basin. Measured values ranged from 218 kg m−3 for a Cordia sagotii (Boraginaceae) from Mountagne de Tortue, French Guiana to 1130 kg m−3 for an Aiouea sp. (Lauraceae) from Caxiuana, Central Pará, Brazil. Analysis of variance showed significant differences in average ρx across regions and sampled plots as well as significant differences between families, genera and species. A partitioning of the total variance in the dataset showed that species identity (family, genera and species) accounted for 33% with environment (geographic location and plot) accounting for an additional 26%; the remaining "residual" variance accounted for 41% of the total variance. Variations in plot means, were, however, not only accountable by differences in species composition because xylem density of the most widely distributed species in our dataset varied systematically from plot to plot. Thus, as well as having a genetic component, branch xylem density is a plastic trait that, for any given species, varies according to where the tree is growing in a predictable manner. Within the analysed taxa, exceptions to this general rule seem to be pioneer species belonging for example to the Urticaceae whose branch xylem density is more constrained than most species sampled in this study. These patterns of variation of branch xylem density across Amazonia suggest a large functional diversity amongst Amazonian trees which is not well understood.
ISSN: 1726-4170

hal-01032137
https://hal.archives-ouvertes.fr/hal-01032137

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
In order to explain the durability of the Moraceae plant family, phytochemistry of Bagassa guianensis was performed. Ethyl acetate extract was obtained from the heartwood and 18 secondary metabolites were isolated, including 6 moracins [6-O-methyl-moracin M, 6-O-methyl-moracin N and moracin Z; previously identified: moracin M, moracin N and moracin P], 8 stilbenoids [presently identified: ( )-epialboctalol and arachidin 4; previously identified: alboctalol, trans-resveratrol, arachidin 2, trans-oxyresveratrol and artogomezianol], 3 previously identified flavonoids, steppogenin, katuranin and dihydromorin, bsitosterol and resorcinol. Previous studies suggest that stilbenoids are responsible for the natural durability of wood. Our study has determined that B. guianensis is closely related to Morus sp. in phylogeny and should be included in the Moreae sensu stricto tribe of the Moraceae family.
ISSN: 0031-9422

hal-00857200
https://hal.archives-ouvertes.fr/hal-00857200
https://hal.archives-ouvertes.fr/hal-00857200/document
https://hal.archives-ouvertes.fr/hal-00857200/file/Secondary_metabolites_Thibaut_al.pdf
DOI : 10.1016/j.phytochem.2010.06.020

Éditeur(s) : HAL CCSD
Résumé : In this thesis, we propose a method to solve some Cauchy problems with irregular or characteristic data by using the recent theories of generalized functions. We study a regular Cauchy problem and a regular Goursat problem in the first part with data on a monotonic curve. The second part is devoted to the setting up of an algebra adapted to the generalized Cauchy problem. In the third part, we give a meaning to a generalized Cauchy problem and we show that the problem admits a unique solution. We study a generalized Goursat problem in the same way. In the fourth part, we approach a characteristic Cauchy problem by a family of non-characteristic ones. The family of solutions is a representative of a generalized function we consider as the generalized solution of the problem in an appropriate algebra. We give a meaning to the characteristic Cauchy problem with irregular data by replacing it by a family of non-characteristic problems in an appropriate biparametric algebra. The first parameter permits to replace the given problem by a non-characteristic one, whereas the second parameter makes it regular. The family of solutions is a representative of a generalized function considered as the solution of the problem.
Dans cette thèse nous proposons une méthode pour résoudre certains problèmes de Cauchy à données irrégulières ou caractéristiques en utilisant les récentes théories des fonctions généralisées. Nous étudions dans la première partie un problème de Cauchy et un problème de Goursat réguliers avec des données sur une courbe monotone. La deuxième partie est consacrée à la mise en place d'une algèbre adaptée à la résolution du problème de Cauchy généralisé. Dans la troisième partie nous donnons un sens à un problème de Cauchy généralisé et nous montrons qu'il admet une unique solution. Nous étudions de même un problème de Goursat généralisé. Dans la quatrième partie nous approchons un problème de Cauchy caractéristique par une famille de problèmes non caractéristiques. La famille de solutions est un représentant d'une fonction généralisée que nous considérons comme la solution généralisée du problème dans une algèbre appropriée. Nous donnons un sens au problème de Cauchy caractéristique dans le cas de données irrégulières en le remplaçant par une famille de problèmes non caractéristiques dans une algèbre convenable dépendant de deux paramètres. Le premier paramètre permet de se ramener à un problème non caractéristique que le second rend régulier. La famille de solutions est un représentant d'une fonction généralisée que nous considérons comme la solution du problème.
https://tel.archives-ouvertes.fr/tel-00012098

Droits : info:eu-repo/semantics/OpenAccess
tel-00012098
https://tel.archives-ouvertes.fr/tel-00012098
https://tel.archives-ouvertes.fr/tel-00012098v2/document
https://tel.archives-ouvertes.fr/tel-00012098/file/These-Devoue-29-12-2006.pdf

Éditeur(s) : HAL CCSD Botanical Society of America
Résumé : Premise of the study : Wood density correlates with mechanical and physiological strategies of trees and is important for estimating global carbon stocks. Nonetheless, the relationship between branch and trunk xylem density has been poorly explored in neotropical trees. Here, we examine this relationship in trees from French Guiana and its variation among different families and sites, to improve the understanding of wood density in neotropical forests. Methods : Trunk and branch xylem densities were measured for 1909 trees in seven sites across French Guiana. A major-axis fit was performed to explore their general allometric relationship and its variation among different families and sites. Key results : Trunk xylem and branch xylem densities were significantly positively correlated, and their relationship explained 47% of the total variance. Trunk xylem was on average 9% denser than branch xylem. Family-level differences and interactions between family and site accounted for more than 40% of the total variance, whereas differences among sites explained little variation. Conclusions : Variation in xylem density within individual trees can be substantial, and the relationship between branch xylem and trunk xylem densities varies considerably among families and sites. As such, whole-tree biomass estimates based on non-destructive branch sampling should correct for both taxonomic and environmental factors. Furthermore, detailed estimates of the vertical distribution of wood density within individual trees are needed to determine the extent to which relying solely upon measures of trunk wood density may cause carbon stocks in tropical forests to be overestimated.
ISSN: 0002-9122

hal-01032401
https://hal.archives-ouvertes.fr/hal-01032401
DOI : 10.3732/ajb.1000034

Éditeur(s) : HAL CCSD Springer Verlag
Résumé :  
Genetic variation for intrinsic water use efficiency (W i) and related traits was estimated in a full-sib family of Quercus robur L. over 3 years. The genetic linkage map available for this F1 family was used to locate quantitative trait loci (QTL) for W i, as estimated by leaf carbon stable isotope composition (δ 13C) or the ratio of net CO2 assimilation rate (A) to stomatal conductance to water vapour (g w) and related leaf traits. Gas exchange measurements were used to standardize estimates of A and g w and to model the sensitivity of g w to leaf-to-air vapour pressure deficit (sgVPD). δ 13C varied by more than 3‰ among the siblings, which is equivalent to 40% variation of W i. Most of the studied traits exhibited high clonal mean repeatabilities (>50%; proportion of clonal mean variability in global variance). Repeatabilities for δ 13C, leaf mass per area (LMA) and leaf nitrogen content were higher than 70%. For δ 13C, ten QTLs were detected, one of which was detected repeatedly for all 3 years and consistently explained more than 20% of measured variance. Four genomic regions were found in which co-localizing traits linked variation in W i to variations in leaf chlorophyll and nitrogen content, LMA and sgVPD. A positive correlation using clonal means between δ 13C and A/g w, as well as a co-localisation of QTL detected for both traits, can be seen as validation of the theoretical model linking the genetic architecture of these two traits.
ISSN: 1614-2942

hal-01032066
https://hal.archives-ouvertes.fr/hal-01032066
DOI : 10.1007/s11295-007-0107-z

Éditeur(s) : Université des Antilles Études caribéennes
Résumé : Sur l'île de Bali, en Indonésie, paradis touristique et culturel, aujourd'hui en proie à un développement trop rapide, les rizières en terrasses constituent une véritable marque de fabrique du paysage local. La campagne autour de Jatiluwih est désormais le site naturel phare récemment reconnu par l'Unesco. Ses fameuses rizières représentent aussi un parfait exemple du fonctionnement des subak balinais, ces systèmes d’irrigation et de gestion de l’eau qui sont traditionnellement ancrés dans la culture balinaise. Ici, culture et agriculture sont intrinsèquement liées, et de plus en plus menacées. Cet article traite du présent et du devenir de la riziculture, patrimonialisée ou non, face à un essor du tourisme qui tous les jours s'affirme plus massif que culturel. Un défi majeur pour les Balinais qui souhaiteraient que leur paradis ne soit pas perdu mais préservé.
On the island of Bali, in Indonesia, a touristic and cultural heaven, nowadays confronted with a too fast development, the typical rice fields form a real distinguishable brand of the local landscape. The countryside around Jatiluwih become now the main natural site recently approved by UNESCO. Its famous rice fields also represent a perfect case of the Balinese system named Subak, a traditional water network deeply rooted in the local culture. Here, culture and agriculture are strongly tied together, but always more threatened these days. This contribution discuss the present and the future of the rice culture, whether put in heritage or not, in the context of a tourism growth which everyday looks more mass than cultural oriented. A major challenge for the Balinese who would prefer to see their paradise not lost but better preserved.
Bali
Indonésie

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.6957
http://journals.openedition.org/etudescaribeennes/6957

Éditeur(s) : Université des Antilles Études caribéennes
Résumé : The Gold Coast in Australia is one of these coastal places, which developed through taking advantage of its environmental assets, such as direct access to the sea, a white sandy shoreline, an extensive and naturally protected broadwater and several large accessible rivers. While many other coastal cities relied on port facilities to develop commercial and naval activities, the City of Gold Coast emerged and grew as a tourism destination. Largely because of this phenomenon, the pattern of settlement and subsequent development of the city differs from most traditional Australian settlement and development patterns. Today, the Gold Coast is one of the most famous tourist cities in Australia and it accommodates more than ten million visitors annually.In the wider Australian context, 85% of the population lives within 50 km of the beach, evidencing popular lifestyle cultural preferences of many Australians. Given this preoccupation with the coast, one may expect that Australia would be at the forefront of coastal tourism developments and coastal protection. There is, however, no overriding jurisdiction covering planning law enforcement in maritime areas and, this situation has led to many social and environmental conflicts. The City of Gold Coast is a case in point and no more so than currently (2017) with proposals to build a cruise terminal or/and a casino, and high rise residential towers on its protected coastal strip (the Spit).This paper demonstrates how the evolution and resolution of development conflicts on the Spit (Gold Coast) are symptomatic of the evolution of place values and the national coastal management and how, this informs a shift towards coastal protection.
La ville côtière de Gold Coast, en Australie, s’est développée grâce à un environnement naturel exceptionnel, qui comprend un accès direct à la mer, un littoral de sable blanc, une large baie naturellement protégée et plusieurs rivières. Si la plupart des autres villes du littoral australien se sont appuyées sur leur port pour développer leurs activités commerciales et navales, la ville de Gold Coast est, depuis ses débuts, une ville touristique. De ce fait, son mode et ses formes de développement se différencient de ceux que l’on rencontre traditionnellement dans les autres villes. Aujourd’hui la ville de Gold Coast est l’une des principales destinations touristiques australiennes et accueille plus de dix millions de visiteurs par an.En Australie, 85% de la population habite dans un rayon de 50km de la plage, avec les préférences de style de vie qui y sont associées. Vu cette attraction pour le littoral, on pourrait présumer que l’Australie soit à l’avant-garde des développements touristiques et de la protection de son littoral. Cependant, du point de vue national, comme, historiquement, il n’y a eu qu’une faible jurdiction concernant l’aménagement et la protection des zones maritimes et du littoral, de nombreux conflits sociaux et environmentaux ont vu le jour. La ville de Gold Coast concentre malheureusement nombre de ces conflits ; le dernier en date concernant le projet de construction d’un terminal de bateaux de croisière et/ou d’un casino avec quelques tours residentielles sur une langue de terre protégée (le Spit).L’objectif de cet article est de montrer comment l’évolution et la résolution des conflits sur le Spit de Gold Coast, tous liés à des projets de développements touristiques, reflètent non seulement l’évolution de la valeur d’un lieu et l’approche nationale du développement du littoral, mais aussi le changement vers une meilleure protection du littoral.
Australie

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.10496
http://journals.openedition.org/etudescaribeennes/10496

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
Cell proliferation is a hallmark of cancer and depends on complex signaling networks that are chiefly supported by protein kinase activities. Therapeutic strategies have been used to target specific kinases but new methods are required to identify combined targets and improve treatment. Here, we propose a small interfering RNA genetic screen and an integrative approach to identify kinase networks involved in the proliferation of cancer cells. The functional siRNA screen of 714 kinases in HeLa cells identified 91 kinases implicated in the regulation of cell growth, most of them never being reported in previous whole-genome siRNA screens. Based on gene ontology annotations, we have further discriminated between two classes of kinases that, when suppressed, result in alterations of the mitotic index and provoke cell-cycle arrest. Extinguished kinases that lead to a low mitotic index mostly include kinases implicated in cytosolic signaling. In contrast, extinguished kinases that result in a high mitotic index mostly include kinases implicated in cell division. By mapping hit kinases in the PhosphPOINT phosphoprotein database, we generated scale-free networks consisting of 449 and 661 protein-protein interactions for kinases from low MI and high MI groups, respectively. Further analyses of the kinase interactomes revealed specific modules such as FER- and CRKL-containing modules that connect three members of the epidermal growth factor receptor (EGFR) family, suggesting a tight control of the mitogenic EGF-dependent pathway. Based on experimental studies, we confirm the involvement of these two kinases in the regulation of tumor cell growth. Based on a combined approach of large kinome-wide siRNA screens and ontology annotations, our study identifies for the first time two kinase groups differentially implicated in the control of cell proliferation. We further demonstrate that integrative analysis of the kinase interactome provides key information which can be used to facilitate or optimize target design for new therapeutic strategies. The complete list of protein-protein interactions from the two functional kinase groups will provide a useful database for future investigations.
ISSN: 1471-2164

hal-01118475
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118475
DOI : 10.1186/1471-2164-15-1169
PUBMED : 25540073

Éditeur(s) : Université des Antilles Études caribéennes
Résumé : Dans la période post-abolitionniste - entre 1848 et 1861 - des milliers de Kongos arrivèrent en Guadeloupe avec le statut d’immigrés pour relancer la production sucrière. Méprisés, ils eurent beaucoup de mal à s'intégrer dans la société créole et ne le firent qu'au prix d'un abandon progressif de leurs traditions, de leur langue, de leur culture et de leur identité. La famille Massembo, malgré un coût social et psychologique, avait conservé et perpétué ses traditions culturelles kongos à travers la cérémonie du « grapp a kongo ». Aujourd’hui, elle est quasiment sortie des ténèbres et son identité affirmée et reconnue.
In the post-abolitionist - between 1848 and 1861 - thousands of Kongos arrived in Guadeloupe with the status of immigrants to boost sugar production. Despised, they had great difficulty integrating into society Creole and did not at the cost of a move away from their traditions, language, culture and identity. Massembo family, despite a high social and psychological had preserved and perpetuated cultural traditions Kongos through the ceremony of "cluster has Kongo". Today it is virtually out of the darkness and identity affirmed and recognized.
Guadeloupe
Congo

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.5795
http://journals.openedition.org/etudescaribeennes/5795

Éditeur(s) : HAL CCSD
Résumé : International audience
The Duffy Antigen/Receptor for Chemokine (DARC) is a seven segment transmembrane protein. It was firstly discovered as a blood group antigen and was the first specific gene locus assigned to a specific autosome in man. It became more famous as an erythrocyte receptor for malaria parasites (Plasmodium vivax and Plasmodium knowlesi), and finally for chemokines. DARC is an unorthodox chemokine receptor as (i) it binds chemokines of both CC and CXC classes and (ii) it lacks the Asp-Arg-Tyr consensus motif in its second cytoplasmic loop hence cannot couple to G proteins and activate their signaling pathways. DARC had also been associated to cancer progression, numerous inflammatory diseases, and possibly to AIDS. In this review, we will summarize important biological data on DARC. Then we shall focus on recent development of the elaboration and analyzes of structural models of DARC. We underline the difficulty to propose pertinent structural models of transmembrane protein using comparative modeling process, and other dedicated approaches as the Protein Blocks. The chosen structural models encompass most of the biochemical data known to date. Finally, we present recent development of protein - protein docking between DARC structural models and CXCL-8 structures. We propose a hierarchal search based on separated rigid and flexible docking.
Infectious disorders drug targets

Droits : info:eu-repo/semantics/OpenAccess
inserm-00366309
http://www.hal.inserm.fr/inserm-00366309
http://www.hal.inserm.fr/inserm-00366309/document
http://www.hal.inserm.fr/inserm-00366309/file/de_Brevern_Autin_Bertrand_Colin_Etchebest.pdf
http://www.hal.inserm.fr/inserm-00366309/file/inserm-00366309_edited.pdf

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
BACKGROUND: A prospective study of infectious encephalitis was conducted in France in 2007. In total, 253 patients were enrolled with a proven etiological diagnosis for 52%. The cohort of surviving patients with encephalitis was assessed for sequelae and impairment 3 years after enrollment. METHODS: Patients, their family, and general practitioners (GPs) were interviewed by phone to document persisting symptoms, return to work, and past and current leisure activities, with standardized questionnaires. The IQCODE (Informant Questionnaire on Cognitive Decline in the Elderly) was completed with relatives. The global outcome was determined in all patients with the Glasgow outcome scale. RESULTS: In 2010, 20 patients (10%) were unavailable for follow-up, 2 (1%) were excluded, and 18 (9%) had died since hospital discharge. Data were available for 167 survivors and 9 patients whose death was related to the encephalitis. The outcome was favorable in 108 of 176 patients (61%) (71 with complete resolution), 31 (18%) were mildly impaired, 25 (14%) were severely impaired, and 3 (1%) were in a vegetative state. The most frequent symptoms were difficulty concentrating (42%), behavioral disorders (27%), speech disorders (20%), and memory loss (19%). Fifteen of 63 patients (24%) previously employed were still unable to resume work. Long-term outcome was significantly associated with comorbid conditions, age, level of education, and the causative agent of encephalitis. CONCLUSIONS: Most patients with encephalitis experienced a favorable outcome 3 years after hospital discharge. However, minor to severe disability persists in a high number of cases with consequences for everyday life. Physical and mental impairment should be evaluated in all patients with encephalitis, and neuropsychological rehabilitation implemented whenever needed.
ISSN: 1058-4838

hal-00875190
https://hal.archives-ouvertes.fr/hal-00875190
DOI : 10.1093/cid/cis226
PUBMED : 22460967

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
Interleukin-27 (IL-27) belongs to the IL-6/IL-12 family of cytokines, associated with different inflammatory diseases and orchestrates its biological activity via common heterodimeric receptor composed of WSX-1 (IL-27Rα) and gp130. The present study was aimed to investigate the regulation of CXCL9, CXCL10, and CXCL11 chemokines in hepatic cells (human LX-2 cell line derived from normal human stellate cells (HSC), primary human hepatocytes, HSC, and HepG2 cells) and concanavalin A (ConA)-induced liver inflammation. We demonstrated that IL-27, but not IL-6, induced/up-regulated CXCR3 ligand genes (CXCL9, CXCL10, and CXCL11; out of 26 selected genes) in a STAT1-dependent manner in hepatic cells in vitro both at transcript and protein levels. In ConA-induced T cell-mediated hepatic model, we showed that soluble IL-27/IFNγ was elevated following ConA hepatitis in association with increased CXCL9, CXCL10, and CXCL11 expression in the liver. The exogenous IL-27 administration induced CXCR3 ligands in mouse liver at 4 h with any significant effect on recruitment of CXCR3(+) immune cells in the liver. The neutralization of IL-27 during ConA hepatitis differentially modulated (transcript vs protein expression) CXCR3 ligands and IFNγ during ConA-induced hepatitis with down-regulated expression of CXCL9 and CXCL10 at transcript level. The IFNγ, complementary regulated the expression of CXCR3 ligands as their up-regulation during ConA hepatitis, was abolished in IFNγ KO mice. In summary, IL-27 up-regulated the CXCL9, CXCL10, and CXCL11 chemokine expression in hepatic cells. IL-27 regulated CXCR3 ligand expression in IFNγ-dependent manner during acute hepatitis suggesting a complementary role of IL-27 and IFNγ to moderate liver inflammation via regulation of CXCR3 ligands. KEY MESSAGE: IL-27 up-regulated CXCR3 ligand expression in human hepatic cells in vitro. IL-27 up-regulated CXCR3 ligand expression and secretion in ConA hepatitis in vivo. CXCR3 ligand expression was down-regulated by blocking IL-27 or IFNγ deficiency. IL-27 modulated liver injury by regulation of CXCR3 ligands in IFNγ-dependent manner.
ISSN: 0946-2716

hal-01214006
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01214006
DOI : 10.1007/s00109-015-1319-6
PUBMED : 26199110

Éditeur(s) : The Japanese Society of Systematic Zoology
Résumé : Prior to this study, two species of ophiuroid had been described from hydrothermal vent sites, and another from methane cold seeps, all from the Atlantic Ocean. Although ophiuroids have occasionally been reported from vents in the Pacific Ocean as well, none has been described before. This study presents two new species, Spinophiura jolliveti gen. et sp. nov., family Ophiuridae, and Ophiolamina eprae gen. et sp. nov., family Ophiacanthidae, which are most likely endemic to reducing environments in the East Pacific. We also include detailed descriptions of the post-metamorphic development of these species. Spinophiura jolliveti is characterized by up to five rather long, semi-erect arm spines and a relatively small oral shield. Its postlarva is unusual in lacking a buccal scale and in that the tooth forms later in development than in all other species the postlarvae of which have been examined. The most characteristic features of O. eprae are the attitude of the three proximal laminar mouth papillae, standing almost vertically on the oral plate, and the presence of two oval, scale-like, distal papillae. Additional migrant (non-vent-endemic) species found at Pacific vent sites are tabularized, but not identified below genus level due to the poor taxonomic state of the Pacific ophiuroid fauna. Biogeographic and ecological issues are discussed.
Species Diversity (1342-1670) (The Japanese Society of Systematic Zoology), 2006-02 , Vol. 11 , N. 1 , P. 7-32

Droits : 2006 The Japanese Society of Systematic Zoology
http://archimer.ifremer.fr/doc/2006/publication-6475.pdf
http://archimer.ifremer.fr/doc/00000/6475/