Éditeur(s) : Himalayan Academy Himalayan Academy ( United States )
Résumé : (Funding) Support for the development of the technical infrastructure and partner training provided by the United States Department of Education TICFIA program.
(Acquisition) This article is published in Hinduism Today http://www.hinduismtoday.com and is shared by the author Vidyaratha Kissoon email vidyak1 (at) gmail dot com. The author Vidyaratha Kissoon has proposed the following corrections to the PDF version. Some corrections have been made in the print version and in the online edition. Errata Sheet for "Guyana's Hindus face Gay Quandary" Page 60 1) The caption on the photograph should be "Activists from the Caribbean at a human rights advocacy workshop in Guyana in August 2010" - 2) The line "After being ruled by the Dutch, the Spanish and finally the British ... " should read "After being ruled by the Dutch and the British".. 3) The line 'Revisions and amendments to the constitution are relatively common' to 'Revisions and amendments to the constitution are necessary to achieving this nationhood' 4) The phrase "Congress of Guyana" should be changed to "Parliament of Guyana" Page 61 4) The line "Hindu institutions were mostly absent from the 2001 debate except for a joint statement issued by a few organisations.." should read "Hindu institutions were mostly absent from the 2003 debate except for a joint multifaith statement which included a few organisations .." 6) The comments by Former UN Secretary General Kofi Annan - referred to laws like those in Guyana (the British colonial Caribbean) 7) The last sentence should read "Freedom of worship is ... and each of the main groups has national holidays [Christmas, Easter, Diwali, Phagwah, Eid ul Adha, Youman Nabi] Page 62 8) The line "Pandit Dhanesar was not able.. " to "Pandit Dhanesar did not provide any specific reference in the Vedas. In Guyana, many Pandits sustain traditions a mix of oral and written traditions" 9) The line "Active in helping the gay and lesbian communities, he advocates acceptance." should read "He advocates acceptance .. " The corrected version of the article appears online at http://hinduismtoday.com/modules/smartsection/item.php?itemid=5172

Droits : All rights reserved by the source institution.

Éditeur(s) : HAL CCSD
Résumé : International audience
Tsavorite is exclusively hosted in the Neoproterozoic Metamorphic Mozambique Belt (NMMB). The gemstone mines, widespread between Kalalani (Tanzania) and Mgama Ridge (Kenya), define a continuous corridor over a hundred kilometers in length. The tsavorite is hosted by a metasedimentary sequence defined as the Kurase tsavorite-bearing metasediments (Kurase-TB metasediments) that also hosts rubies. These metasediments underwent amphibolite-facies metamorphism and are surrounded by granulitic gneisses that are also of sedimentary origin (the Kurase high-temperature gneisses). All these rocks lie below the Kasigau Group, a unit dominated by granulite-facies metamagmatic rocks.To constrain the timing of events that led to this peculiar occurrence of tsavorite, we have performed geochronological analyses of thin sections and of separated grains of zircon, monazite, and rutile using LA-ICP-MS and ID-TIMS, as well as 40Ar/39Ar of muscovite and phlogopite from various lithologies. The results show that the different terranes were metamorphosed synchronously between 620–580 Ma but under different P-T strain conditions. The Kurase-HT gneisses and the rocks from the Kasigau Group are highly strained and underwent granulite-facies metamorphism with abundant partial melting and emplacement of felsic melts between 620 and 600 Ma. Textural observations also underlined a late regional water flux controlling the occurrence of V-free muscovite and monazite mineralizations at 585 Ma. The latter event can be related to the activity of the Galana shear zone, in the east. The Kurase-TB metasediments escaped strain and partial melting. They record amphibolite-facies conditions with static heating, since initial sedimentary structures were locally preserved. The age of the tsavorite mineralization was inferred at 600 Ma from metamorphic zircon rims and monazite from the closest host-rocks, sampled in the mines. Hence, tsavorite crystallization occurred statically at the end of the metamorphic event, probably when the temperature and the amount of volatiles were at maximum levels.Conversely, the ruby formed by local metasomatism of felsic dikes and isolated ultramafic bodies. The rubies are older and zircons and monazites from a ruby-bearing felsic dike (plumasite) were dated at 615 Ma. Finally, data from rutile and micas indicate a global cooling below 430 °C of the whole region between 510 and 500 Ma.
The Canadian Mineralogist

hal-01616037
https://hal.archives-ouvertes.fr/hal-01616037
https://hal.archives-ouvertes.fr/hal-01616037/document
https://hal.archives-ouvertes.fr/hal-01616037/file/JEM.pdf
DOI : 10.3749/canmin.1700019

Éditeur(s) : HAL CCSD
Résumé : International audience
Leishmania parasites induce an immunomodulation by subverting the host immune response towards a CD4(+) Th2 lymphocytic cell response that favors parasite persistence. Here, we report that after successful treatment of visceral leishmaniasis due to Leishmania infantum, an immune reconstitution syndrome revealing hip septic arthritis was associated with a switch from Th2 towards a Th1 cytokine profile, and a decrease in the level of immunomodulating factors, such as soluble HLA-G and indoleamine 2,3-dioxygenase (IDO) activity. We then measured IDO activity in a cohort of 39 patients and uninfected control subjects. Results showed significantly enhanced IDO activity in patients with visceral Leishmania infection, compared with uninfected control subjects (P < 0.001), but also compared with treated patients (P < 0.05). A decrease in IDO activity could constitute a relevant biomarker for the restoration of the immune response during visceral leishmaniasis.
Innate Immunity

inserm-00818884
http://www.hal.inserm.fr/inserm-00818884
DOI : 10.1177/1753425912473170
PUBMED : 23413147

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The complex electrical impedance of a garnet-biotite-sillimanite residual enclave in the Neogene dacite of El Hoyazo (SE Spain) has been determined up to 978 °C at 200-300 MPa. This well studied material represents a direct sampling of the Alborán Domain thinned lower crust undergoing partial melting. The paragenesis is garnet + biotite + sillimanite + plagioclase + graphite ± cordierite coexisting with widespread (~ 10 wt.%) rhyolitic melt occurring as inclusions and interstitial glass and developed during regional anatexis at 850 ± 50 °C and 500-700 MPa. The samples were used in cyclic measurements consisting in heating-cooling ramps at progressively higher maximum temperature to observe the effect of reactions on conductivity. In the first cycle up to 850 °C at 2-3 kbar, re-melting of the interstitial glass is achieved with no additional reactions and logarithmic conductivity (S/m) is up to − 1.5. At T > 950 °C new melt with orthopyroxene + ilmenite is produced from biotite partial breakdown and the logarithmic conductivity (S/m) is up to − 0.7. Application of mixing models as Hashin-Shtrikman bounds or Archie's Law, shows that once interconnected, melt controls the electrical conductivity of the enclave. The electrical conductivity of the rock can be simulated with the electrical conductivity data obtained on the starting Matrix glass of the enclave and with the new melt. Our experimental results obtained on a graphitic metasedimentary material evidence show that graphite does not contribute to the conductivity enhancement and that the electrical anomaly observed below the Betics can be explained as effect of partial melting of a residual crust. Comparison with previous works on mafic granulites shows that similar conductivity values can be achieved both by melting of a residual felsic crust or by melting of mafic materials and suggests that pelitic rocks can be more common at deep levels than expected.
ISSN: 0040-1951

hal-00823063
https://hal.archives-ouvertes.fr/hal-00823063
DOI : 10.1016/j.tecto.2012.11.003

Éditeur(s) : Université Bordeaux 1
Résumé : The mercury cycle was explored in the Petit-Saut reservoir / Sinnamary Estuary continuum in French Guiana. Main processes involve (i) photo-induced reduction, (ii) adsorption and desorption at the particle surfaces, (iii) methylating bacterial activity, (iv) precipitation and dissolution of iron oxyhydroxides and sulfides. Sources of mercury to the Petit-Saut reservoir consist of the partly impacted river-tributaries, the atmospheric deposition and the flooded soils or vegetation. Once into the reservoir, divalent mercury undergoes a large spectrum of transformations including speciation and phase changes. We, here, probe these processes and demonstrate that the Petit-Saut reservoir behaves as a privileged site for atmospheric recycling and in situ methylation. At the air / water interface, the mercury evasion exceeds by 50 % the direct atmospheric deposition. The in situ monomethylmercury (MMHg) production mostly occurs at the water-column chemocline and near the benthic interface. It reaches, for the whole reservoir, 8.1 moles yr-1 which corresponds to a 0.06 % d-1 methylation rate. We calculated that the 2003/04 period MMHg outputs from the reservoir to the Sinnamary Estuary averaged 13.5 moles yr-1 while the inputs were 5.4 moles yr-1. The dynamic Sinnamary Estuary is the genuine geochemical reactor of the continuum. There, the divalent mercury undergoes rapid yet profound partitioning among phases, recycling to the atmosphere and methylation processes. Those mostly originate from the long-scale oxygen paucity of the dam discharged waters. The expression of marked redox gradients and the intense organic matter turnover enhance the production of methylable inorganic mercurial species and tend to favor the sulfate reducing bacteria (methylating agents) activity. As a result, the dynamic Sinnamary Estuary exports 60 % more MMHg than it does import: 27 versus 17 moles yr-1. Further at large, in the saline estuary, we determined: (i) a non conservative behavior of dissolved (< 0.2 µm) mercury, (ii) a lowering of the mercury level of particles during mixing with the Amazon plume and (iii) a gradual dilution of the estuarine mercury concentrations by oceanic waters.
La retenue de Petit-Saut et, à l'aval, l'estuaire du Sinnamary sont deux centres d'altération du cycle naturel du mercure. Les processus sont, entre autres, (i) la photoréduction, (ii) la sorption / désorption en surface des particules, (iii) l'activité méthylante des bactéries, (iv) la dissolution / précipitation des oxyhydroxydes et des sulfures de fer. Les sources de mercure vers la retenue sont variées. Elles regroupent, en premier lieu, les affluents (partiellement orpaillés), l'atmosphère, les sols et la végétation ennoyés. Dans la colonne d'eau, les formes divalentes du mercure subissent un train complet de transformations couplant changements de phase et de spéciation. Nos résultats illustrent ces processus et démontrent que la retenue constitue un site privilégié de recyclage vers l'atmosphère et de méthylation. A l'interface air / eau, les exports en mercure de la retenue excèdent de 50 % le dépôt atmosphérique. La production endogène de monométhylmercure (MMHg) a lieu dans des sites particuliers : la chemocline et l'interface benthique. Elle atteint pour l'ensemble de la retenue 8,1 moles a-1 soit un taux de méthylation de 0,06 % j-1. On estime que la retenue exporte vers l'estuaire du Sinnamary 13,5 moles a-1 de MMHg alors qu'elle n'importe que 5,4 moles a-1. L'estuaire dynamique du Sinnamary constitue le véritable réacteur chimique du système fonctionnant en liaison avec celui de la retenue. Le mercure y décrit un cycle rapide aux processus de partition, de recyclage et de méthylation marqués. Ces processus résultent de l'oxygénation incomplète et durable des masses d'eau anoxiques exportées par la retenue de Petit-Saut. L'expression de gradients rédox prononcés conjuguée à un intense recyclage de la matière organique y favorise la production de formes méthylables de mercure ainsi que l'activité des bactéries sulfatoréductrices (agents de la méthylation). C'est pourquoi, l'estuaire dynamique du Sinnamary exporte 60 % plus de MMHg qu'il n'importe : 27 contre 17 moles a-1. Plus en aval, dans l'estuaire salin, nous avons mis en évidence : (i) un comportement non conservatif du mercure dissous, (ii) un appauvrissement du mercure des particules suite au mélange avec le panache de l'Amazone et (iii) une dilution des concentrations par les masses d'eau océaniques.

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/2006/these-1508.pdf
http://archimer.ifremer.fr/doc/00000/1508/

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Chronic liver damage due to viral or chemical agents leads to a repair process resulting in hepatic fibrosis. Fibrosis may lead to cirrhosis, which may progress to liver cancer or a loss of liver function, with an associated risk of liver failure and death. Chlordecone is a chlorinated pesticide used in the 1990s. It is not itself hepatotoxic, but its metabolism in the liver triggers hepatomegaly and potentiates hepatotoxic agents. Chlordecone is now banned, but it persists in soil and water, resulting in an ongoing public health problem in the Caribbean area. We assessed the probable impact of chlordecone on the progression of liver fibrosis in the population of contaminated areas, by developing a mouse model of chronic co-exposure to chlordecone and a hepatotoxic agent, carbon tetrachloride (CCl4). After repeated administrations of chlordecone and CCl4 by gavage over a 12-week period, we checked for liver damage in the exposed mice, by determining serum liver transaminase (AST, ALT) levels, histological examinations of the liver and measuring the expression of genes encoding extracellular matrix components. The co-exposure of mice to CCl4 and chlordecone resulted in significant increases in ALT and AST levels. Chlordecone also increased expression of the Col1A2, MMP-2, TIMP-1 and PAI-1 genes in CCl4-treated mice. Finally, we demonstrated, by quantifying areas of collagen deposition and alpha-SMA gene expression, that chlordecone potentiated the hepatic fibrosis induced by CCl4. In conclusion, our data suggest that chlordecone potentiates hepatic fibrosis in mice with CCl4-induced chronic liver injury
ISSN: 0378-4274

hal-01274228
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01274228
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01274228/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01274228/file/Chlordecone%20potentiates%20hepatic%20fibrosis%20%281%29.pdf
DOI : 10.1016/j.toxlet.2016.02.005

Éditeur(s) : Saunders & Otley Saunders & Otley ( London )
Résumé : " ... it is taken from a very voluminous manuscript, which partakes of the mixed nature of memoirs, a journal, an autobiography, and a collection of letters and essays. These bore, in their title-page the following inscription : "The life, adventures, and opinions, of Warner Arundell, Esquire"--Editor's Introd.
(Statement of Responsibility) [edited and compiled] by E.L. Joseph.
West Indies
West Indies
Venezuela
London (England)

Droits : Applicable rights reserved.
47961383
ocm47961383

Éditeur(s) : HAL CCSD
Résumé : International audience
The aim of this study was to optimize the extraction and characterization of lycopene, a carotenoid, from a tropical fruit, Psidium guajava L. and to demonstrate its health benefits. Deionised water, mixed with organic solvents, was used for extraction, and the depletion stage was reached in order to define the number of extractions needed to extract most of the lycopene. Optimum extraction was achieved with petroleum ether combined with guava puree:deionised water ratio of 40% using 15 ml of water. Four extractions were a satisfactory compromise to maximize the amount of lycopene recovered and to minimize the use of organic solvent. Excellent purification of lycopene was obtained by HPLC-VIS detection (470 nm) with acetonitrile/methanol/tetrahydrofuran mobile phase. Characterization was confirmed by FTIR analysis. A modification of the DPPH test made it possible to assess the EC50, thereby ranking lycopene among good antioxidants. As Psidium guajava is already widely used in the food industry, these results support claims for health benefits for products derived from guava.
ISSN: 23192399

hal-01672063
https://hal.univ-antilles.fr/hal-01672063
DOI : 10.9790/2402-1104016773

Éditeur(s) : Amer Geophysical Union
Résumé : At its seasonal peak the Amazon/Orinoco plume covers a region of 10^6 km2 in the western tropical Atlantic with more than 1m of extra freshwater, creating a near-surface barrier layer (BL) that inhibits mixing and warms the sea surface temperature (SST) to >29oC. Here new sea surface salinity (SSS) observations from the Aquarius/SACD and SMOS satellites help elucidate the ocean response to hurricane Katia, which crossed the plume in early fall, 2011. Its passage left a 1.5psu high haline wake covering >10^5 km2 (in its impact on density, the equivalent of a 3.5oC cooling) due to mixing of the shallow BL. Destruction of this BL apparently decreased SST cooling in the plume, and thus preserved higher SST and evaporation than outside. Combined with SST, the new satellite SSS data provide a new and better tool to monitor the plume extent and quantify tropical cyclone upper ocean responses with important implications for forecasting.
Geophysical Research Letters (0094-8276) (Amer Geophysical Union), 2012-10 , Vol. 39 , N. L20603 , P. 1-8

Droits : 2012. American Geophysical Union. All Rights Reserved.
http://archimer.ifremer.fr/doc/00094/20540/18943.pdf
DOI:10.1029/2012GL053335
http://archimer.ifremer.fr/doc/00094/20540/

Éditeur(s) : HAL CCSD Nature Publishing Group
Résumé : International audience
Hepatocyte death is a central event during liver disease progression, in which immune cells play key roles by activating members of the Tumor Necrosis Factor Receptor Superfamily (TNFRSF), including TNFR1 (TNFRSF1A), Fas (TNFRSF6) and TRAIL-R2 (TNFRSF10B). Receptor Interacting Protein Kinase 1 (RIPK1) emerged as a signaling node downstream of these receptors. In the case of TNFR1, RIPK1 has been demonstrated to paradoxically serve as a scaffold to promote the survival of hepatocytes and as a kinase to kill them. To evaluate whether RIPK1 also protects hepatocytes from death in response to FasL or TRAIL, we took advantage of liver parenchymal cell-specific Ripk1 knockout mice (Ripk1 (LPC-KO)). We found that Ripk1 (LPC-KO) mice, as well as primary hepatocytes derived from them, were more susceptible to Fas-mediated apoptosis than their respective WT counterparts. Fas-induced hepatocyte death was independent of TNF-α signaling. Interestingly, while TRAIL administration did not induce hepatitis in Ripk1 (LPC-KO) mice or in their WT counterparts, its combination with IFN-γ only induced TNF-α dependent apoptosis in the Ripk1 (LPC-KO) mice. Together, our data demonstrate the protective role of RIPK1 downstream of Fas and highlight the general protective function of RIPK1 in hepatocytes exposed to inflammatory conditions, where TNF-α, FasL and/or TRAIL are present.
ISSN: 2045-2322

hal-01579612
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01579612
DOI : 10.1038/s41598-017-09789-8
PUBMED : 28835677

Éditeur(s) : Saunders & Otley Saunders & Otley ( London )
Résumé : " ... it is taken from a very voluminous manuscript, which partakes of the mixed nature of memoirs, a journal, an autobiography, and a collection of letters and essays. These bore, in their title-page the following inscription : "The life, adventures, and opinions, of Warner Arundell, Esquire"--Editor's Introd.
(Statement of Responsibility) [edited and compiled] by E.L. Joseph.
West Indies
West Indies
Venezuela
London (England)

Droits : Not in copyright per Internet Archive: http://archive.org/details/warnerarundella00josegoog
47961383
ocm47961383
http://ufdc.ufl.edu/AA00012102/00001

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
BACKGROUND: Environmental factors such as pesticides can cause phenotypic changes in various organisms, including mammals. We studied the effects of the widely used herbicide atrazine (ATZ) on meiosis, a key step of gametogenesis, in male mice. METHODS: Gene expression pattern was analysed by Gene-Chip array. Genome-wide mapping of H3K4me3 marks distribution was done by ChIP-sequencing of testis tissue using Illumina technologies. RT-qPCR was used to validate differentially expressed genes or differential peaks. RESULTS: We demonstrate that exposure to ATZ reduces testosterone levels and the number of spermatozoa in the epididymis and delays meiosis. Using Gene-Chip and ChIP-Seq analysis of H3K4me3 marks, we found that a broad range of cellular functions, including GTPase activity, mitochondrial function and steroid-hormone metabolism, are affected by ATZ. Furthermore, treated mice display enriched histone H3K4me3 marks in regions of strong recombination (double-strand break sites), within very large genes and reduced marks in the pseudoautosomal region of X chromosome. CONCLUSIONS: Our data demonstrate that atrazine exposure interferes with normal meiosis, which affects spermatozoa production
ISSN: 1471-2164

hal-01225493
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01225493
DOI : 10.1186/s12864-015-2095-y
PUBMED : 26518232

Éditeur(s) : University of Tasmania, Université de Bretagne Occidentale
Résumé : Empirical evidence and the theoretical literature both point to stock sustainability and the protection of marine biodiversity as important fisheries management issues. Decision-support tools are increasingly required to operationalize the ecosystem-based approach to fisheries management. These tools need to integrate (i) ecological and socio-economic drivers of changes in fisheries and ecosystems; (ii) complex dynamics; (iii) deal with various sources of uncertainty; and (iv) incorporate multiple, rather than single objectives. The stochastic co-viability approach addresses the trade-offs associated with balancing ecological, economic and social objectives throughout time, and takes into account the complexity and uncertainty of the dynamic interactions which characterize exploited ecosystems and biodiversity. This thesis proposes an application of this co-viability approach to the sustainable management of mixed fisheries, using two contrasting case studies: the French Bay of Biscay (BoB) demersal mixed fishery and the Australian Northern Prawn Fishery (NPF). Both fisheries entail direct and indirect impacts on mixed species communities while also generating large economic returns. Their sustainability is therefore a major societal concern. A dynamic bio-economic modelling approach is used to capture the key biological and economic processes governing these fisheries, combining age- (BoB) or size- (NPF) structured models of multiple species with recruitment uncertainty, and multiple fleets (BoB) or fishing strategies (NPF). Economic uncertainties relating to input and output prices are also considered. The bioeconomic models are used to investigate how the fisheries can operate within a set of constraints relating to the preservation of Spawning Stock Biomasses (BoB) or Spawning Stock Size Indices (NPF) of a set of key target species, maintenance of the economic profitability of various fleets (BoB) or the fishery as a whole (NPF), and limitation of fishing impacts on the broader biodiversity (NPF), under a range of alternative scenarios and management strategies. Results suggest that under a status quo strategy both fisheries can be considered as biologically sustainable, while socio-economically (and ecologically in the NPF case) at risk. Despite very different management contexts and objectives, viable management strategies suggest a reduction in the number of vessels in both cases. The BoB simulations allow comparison of the trade-offs associated with different allocations of this decrease across fleets. Notably, co-viability management strategies entail a more equitable allocation of effort reductions compared to strategies aiming at maximizing economic yield. In the NPF, species catch diversification strategies are shown to perform well in controlling the levels of economic risk, by contrast with more specialized fishing strategies. Furthermore analyses emphasize the importance to the fishing industry of balancing global economic performance with inter-annual economic variability. Promising future developments based on this research involve the incorporation of a broader set of objectives including social dimensions, as well as the integration of ecological interactions, to better address the needs of ecosystem-based approaches to the sustainable harvesting of marine biodiversity.
L’objectif général de la thèse est de modéliser les principaux processus biologiques et économiques régissant des pêcheries multi-espèces et multi-flottilles afin de proposer des stratégies viables pour la gestion durable de ces pêcheries mixtes, dans un contexte stochastique et multiobjectif. Plus spécifiquement, cette thèse utilise des analyses de co-viabilité stochastique pour étudier les arbitrages entre des objectifs contradictoires de gestion (conservation, et viabilité économique et sociale) des pêcheries mixtes. Deux pêcheries mixtes sont analysées dans cette thèse: la pêcherie française mixte démersale du golfe de Gascogne et la pêcherie crevettière australienne du Nord (NPF). Ces deux pêcheries sont multi-espèces, et utilisent des stratégies multiples de pêche, induisant des impacts directs et indirects sur les écosystèmes. Cette thèse propose une application de la co-viabilité stochastique à ces deux cas, en prenant en compte leur histoire, leur contexte socio-politique et les différences dans les stratégies et objectifs de gestion. Les résultats suggèrent que le status quo peut être considéré comme une stratégie biologiquement durable mais socio économiquement à risque dans les deux pêcheries (ainsi qu’à risque écologique dans le cas de la pêcherie australienne). Les simulations réalisées pour le golfe de Gascogne permettent de comparer les arbitrages associés à différentes réductions de capacités par flottille et de montrer qu’il existe des solutions de gestion permettant la co-viabilité du système (viabilité biologique des différentes espèces considérées et viabilité socio-économique des flottilles) contrairement à des stratégies de gestion mono-spécifiques ou basées sur la maximisation de la rente. Dans la pêcherie crevettière australienne, l’analyse montre que les stratégies de diversification permettent de limiter le risque économique contrairement aux stratégies plus spécialisées.

Droits : UBO, Univ. Tasmania
http://archimer.ifremer.fr/doc/00206/31731/30134.pdf
http://archimer.ifremer.fr/doc/00206/31731/

Éditeur(s) : Pergamon-elsevier Science Ltd
Résumé : The late Quaternary has experienced large glacial/interglacial climatic variations and related 10's to 100 meters high-amplitude sea level fluctuations at Milankovich frequencies from 10's to 100 kyr during which carbonate platform tops have been exposed and re-flooded in many occasions. This study focuses on the accumulation of calci-turbidites, the aragonite onset/sharp increase in fine sediments and their timing in deep basins adjacent to carbonate platforms. A particular emphasis is developed on the occurrence of the first gravity flow event and aragonite onset/sharp increase and their linkage to the initial re-flooding of the platform tops during deglaciations. Three basins adjacent to isolated platforms in the Bahamas, the Northern Nicaragua Rise, and the Gulf of Papua, were selected to represent pure carbonate versus mixed systems, in quiescent versus tectonically active settings, and various carbonate bank top morphologies, ranging from atoll to relatively deeply and narrowly flooded flat top banks. In spite of these differences, each record illustrates a clear relationship between the timing of platform top re-flooding and initiation of significant carbonate export by gravity flows and low-density plumes into the surrounding basins. The concept of "re-flooding window" is introduced to characterize the prolific period of time during which bank and atoll-tops are flooded enough to produce large export of bank-derived aragonite and of calci-turbidites in adjacent basins. According to our datasets, the main re-flooding windows have occurred mainly on the last part of the sea level rise at each glacial termination (T), those periods being marked by some of the highest rates of sea level rise. The analysis of a long-piston core from the earthquakes-prone Walton Basin (Northern Nicaragua Rise) demonstrates that sea level, not seismic activities, played a major role as trigger mechanism for the initiation of gravity flows since the last four glacial/interglacial transitions, and supports the existence of an extra glacial termination during the early portion of the transition from MIS 7.4 to MIS 7.3 (TIIIA). (C) 2010 Elsevier Ltd. All rights reserved.
Quaternary Science Reviews (0277-3791) (Pergamon-elsevier Science Ltd), 2010-08 , Vol. 29 , N. 17-18 , P. 2010-2026

Droits : 2010 Elsevier Ltd All rights reserved.
http://archimer.ifremer.fr/doc/00012/12298/9095.pdf
DOI:10.1016/j.quascirev.2010.04.016
http://archimer.ifremer.fr/doc/00012/12298/

Éditeur(s) : HAL CCSD
Résumé : National audience
We propose a method to solve the problem of clustering individuals described by mixed variables structured in blocks. It is a hierarchical method with two levels similar to Hierarchical Principal Component Analysis presented by Wold, based on the mixed topology maps (MTM). The first step consists in establishing, for each block of mixed variables, a clustering representing a synthesis of local individuals at the block level. The second step is to re-apply MTM on the weighted results of the first level. We obtain a global clustering of individuals, consensus among the partitions from level 1. The proposed method is illustrated on data from the national survey in the French housing stock carried out in 2003-2005 by the Observatory for Indoor Air Quality (OQAI).
Fouille de Données Complexes, complexité liée aux données multiples et massives (FDC)
bordeaux, France

hal-00748841
https://hal.archives-ouvertes.fr/hal-00748841
https://hal.archives-ouvertes.fr/hal-00748841/document

Éditeur(s) : HAL CCSD Geological Society of London
Résumé : International audience
In Eastern China, the North China Block (NCB) has experienced a complex tectonic evolution during Late Palaeozoic to Mesozoic times. The unconformable sedimentary cover, which ranges in age from Neoproterozoic to Permian, underwent two tectonic episodes in Early Triassic and Cretaceous times. An early north–south compressional phase, D1, characterized by north-verging recumbent folds with east–west-trending axes and top-to-the-north ductile shear zones can be observed in a gabbroic pluton and the Neoproterozoic sedimentary host rocks. The available radiometric ages allow us to interpret this event as an Early Triassic back-thrusting related to the final stage of the collision between the North China and South China Blocks. During the LateMesozoic, an extensional event characterized by (1) half-grabens filled by continental terrigeneous red beds and lava flows, (2) low-angle detachment faults, (3) synkinematic granitic plutons, and (4) metamorphic core complexes is widespread in the Eastern Liaoning Peninsula. This extensional D2 event can be subdivided into a ductile deformation and a brittle deformation, corresponding to different expressions of crustal deformation. In every area studied in the Eastern Liaoning Peninsula, the ductile D2 deformation is characterized by a NW–SE-trending stretching lineation with a top-to-the-NWsense of shear.Mica and amphibole fromthe metamorphic country rocks, granodioritic or monzogranitic plutons and their mylonitized margins yield 40Ar/39Ar ages ranging from 130 to 120 Ma. These dates support fast cooling and exhumation rates coeval with the extensional tectonics. The brittle D2 deformation is responsible for the formation of high-angle normal faults marked by low-temperature cataclasites bounding half-grabens. During the Mesozoic, the tectonic regime of Eastern China experienced a significant inversion from compression to extension. The Eastern Liaoning Peninsula massif provides an example of this geodynamic transition.
ISSN: 2041-4927

hal-00134055
https://hal-insu.archives-ouvertes.fr/hal-00134055
DOI : 10.1144/SP280.7

Éditeur(s) : HAL CCSD Nature Publishing Group
Résumé : International audience
Cell death of hepatocytes is a prominent characteristic in the pathogenesis of liver disease, while hepatolysis is a starting point of inflammation in hepatitis and loss of hepatic function. However, the precise molecular mechanisms of hepatocyte cell death, the role of the cytokines of hepatic microenvironment and the involvement of intracellular kinases, remain unclear. Tumor necrosis factor alpha (TNF-α) is a key cytokine involved in cell death or survival pathways and the role of RIPK1 has been associated to the TNF-α-dependent signaling pathway. We took advantage of two different deficient mouse lines, the RIPK1 kinase dead knock-in mice (Ripk1K45A) and the conditional knockout mice lacking RIPK1 only in liver parenchymal cells (Ripk1LPC-KO), to characterize the role of RIPK1 and TNF-α in hepatitis induced by concanavalin A (ConA). Our results show that RIPK1 is dispensable for liver homeostasis under steady-state conditions but in contrast, RIPK1 kinase activity contributes to caspase-independent cell death induction following ConA injection and RIPK1 also serves as a scaffold, protecting hepatocytes from massive apoptotic cell death in this model. In the Ripk1LPC-KO mice challenged with ConA, TNF-α triggers apoptosis, responsible for the observed severe hepatitis. Mechanism potentially involves both TNF-independent canonical NF-κB activation, as well as TNF-dependent, but canonical NF-κB-independent mechanisms. In conclusion, our results suggest that RIPK1 kinase activity is a pertinent therapeutic target to protect liver against excessive cell death in liver diseases. © The Author(s) 2016.
ISSN: 2041-4889

hal-01414916
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01414916
DOI : 10.1038/cddis.2016.362
PUBMED : 27831558

Résumé : Label 7439 / 4 plates
Around the turn of the 20th century, cigars were advertised and sold mainly by the colourful, intricate labels that adorned the boxes. Intense competition encouraged manufacturers to see who could create the most beautiful, eye-catching labels. A diffrent stone was required to print each colour. It was not unusual for as many as 20 stones to be used to create a single label. The register for each printing had to be perfect. The process became known as STONE LITHOGRAPHY or CHROMOLITHOGRAPHY. Once this exacting printing process was completed, the labels were then gilded with hand-applied gold leaf. Finally, the labels were embossed using huge 30-ton presses. According to Joe Davidson, the eminent American art dealer and collector, the "Golden Era" of cigar labels is associated with the introduction of gilding and embossing in the 1890's up to the late 1920's when the less attractive full-colour or photo-mechanical labels began to appear. Genuine gold leaf was used primarily by German and Cuban printers and "bronzing" in which bronze powder was mixed with lacquer or sizing, applied like ink, then burnished with brushes or polished rollers to make them gleam like gold. These particular labels were produced by the German factory, Gerhard Meinesz in Bentheim, near the Dutch border, and closed in 1932. The labels were used during the 1920's. These spectacular lithographs lithographs wound up lying unused and undiscovered for generations. Because they were printed on special long-fibre, acid-free rage paper, these old labels retained their original brilliant colours. Consequently, they are available in very limited quantities.
(Funding) Funded in part by the Institute for Museum and Library Services (IMLS), Ephemeral Cities Project.
Tampa |z 1271000 |2 ceeus
Hillsborough County |z 12057 |2 ceeus
United States of America -- Florida -- Hillsborough County -- Tampa

Droits : All rights reserved. 2005.
C24-05394

Éditeur(s) : HAL CCSD
Résumé : International audience
The SOX8 and SOX9 transcription factors are involved in, among others, sex differentiation, male gonad development and adult maintenance of spermatogenesis. Sox8(-/-) mice lacking Sox9 in Sertoli cells fail to form testis cords and cannot establish spermatogenesis. Although genetic and histological data show an important role for these transcription factors in regulating spermatogenesis, it is not clear which genes depend upon them at a genome-wide level. To identify transcripts that respond to the absence of Sox8 in all cells and Sox9 in Sertoli cells we measured mRNA concentrations in testicular samples from mice at 0, 6 and 18 days post-partum. In total, 621 and 629 transcripts were found at decreased or increased levels, respectively, at different time points in the mutant as compared to the control samples. These mRNAs were categorized as preferentially expressed in Sertoli cells or germ cells using data obtained with male and female gonad samples and enriched testicular cell populations. Five candidate genes were validated at the protein level. Furthermore, we identified putative direct SOX8 and SOX9 target genes by integrating predicted SOX-binding sites present in potential regulatory regions upstream of the transcription start site. Finally, we used protein network data to gain insight into the effects on regulatory interactions that occur when Sox8 and Sox9 are absent in developing Sertoli cells. The integration of testicular samples with enriched Sertoli cells, germ cells and female gonads enabled us to broadly distinguish transcripts directly affected in Sertoli cells from others that respond to secondary events in testicular cell types. Thus, combined RNA profiling signals, motif predictions and network data identified putative SOX8/SOX9 target genes in Sertoli cells and yielded insight into regulatory interactions that depend upon these transcription factors. In addition, our results will facilitate the interpretation of genome-wide in vivo SOX8 and SOX9 DNA binding data.
Andrology

hal-00877013
https://hal.archives-ouvertes.fr/hal-00877013
DOI : 10.1111/j.2047-2927.2012.00049.x
PUBMED : 23315995

Éditeur(s) : Neidine Editeurs
Résumé : This text presents a review of the various technologies for exploitation of renewable marine energy resources. Il exposes the solutions offered by tide and currents, swell and waves, the marine wind energy, the Ocean Thermal Energy, the osmotic energy and specifies the various degrees of technological maturity for each solution. This new economic activity on the littoral and coastal areas also contains indirect effects in terms of management which are called back. The inter-tropical islands benefit from a very vast potential for the insertion of these renewable sources of energy in their mix of energy production. Although the exploitation of these energies is not still the object of a programming in New Caledonia, an overview of the specificities of the country allows to think that certain medium term solutions will be possible.
Ce texte présente une revue des différentes technologies d’exploitation des ressources énergétiques qui peuvent être tirées de la mer. On expose ainsi les solutions offertes par la marée et les courants, la houle et les vagues, l’éolien marin, l’énergie thermique des mers, l’énergie osmotique et on précise les degrés de maturité technologique très échelonnés de chaque solution. Cette nouvelle activité économique sur l’espace littoral et côtier comporte également des effets indirects en termes d’aménagement qui sont rappelés. Les îles inter-tropicales bénéficient d’un très vaste potentiel pour l’insertion de ces EMR dans leur mix de production énergétique. Bien que l’exploitation de ces énergies ne fasse pas encore l’objet d’une programmation en Nouvelle-Calédonie, un rappel des spécificités du pays permet de penser que certaines solutions seront envisageables à moyen terme.
Tai Kona (2269-7535) (Neidine Editeurs), 2013-09 , N. 4 , P. 24-40

Droits : Tai kona
http://archimer.ifremer.fr/doc/00174/28504/26853.pdf
http://archimer.ifremer.fr/doc/00174/28504/