Éditeur(s) : HAL CCSD Taylor & Francis (Routledge)
Résumé : International audience
The Maroni basin, an isolated region delineating the border between Suriname and French Guiana has been affected by the human immunodeficiency virus (HIV) epidemic 10 years after coastal French Guiana. However, the rise in HIV prevalence was sharp, exceeding 1% within 10 years. The aim of the present study is to compare, using the first quantitative data from the general population in remote villages, the knowledge, attitudes, and behaviors regarding HIV between Maroon and Amerindian populations, the two most frequent populations living along the Maroni. Data were collected in 2012 using a structured questionnaire among a random sample of 896 individuals residing in the remote villages on the Maroni river. Proportions were compared between the Maroni and the coastal general population, and between Maroon and Amerindian populations. The present study shows significant differences between territories and between communities living on the Maroni river: the multiple sexual partnerships, more common among population living on the Maroni river, were more frequently reported in Maroons than in Amerindians. Condom use was more frequently reported among men on the Maroni river than on the coast, but these findings were reversed for women. Moreover, among people living on the Maroni river, condom use was more frequently reported among Maroons than among Amerindians. Regarding genital factors that may affect transmission, penile implant seemed to have no ethnic boundaries, steam baths seemed specific to Maroon women. The present results should help to improve community-based specific interventions.
ISSN: 0954-0121

hal-01260915
https://hal.archives-ouvertes.fr/hal-01260915
https://hal.archives-ouvertes.fr/hal-01260915/document
https://hal.archives-ouvertes.fr/hal-01260915/file/2015%2C%20Van%20Melle%20-%20Knowledge%2C%20attitudes%2C%20behaviors%2C%20and%20practices%20differences%20regarding%20HIV.pdf
DOI : 10.1080/09540121.2015.1032203

Éditeur(s) : HAL CCSD Nature Publishing Group
Résumé : International audience
Androgen signaling, via the androgen receptor (AR), is crucial in mediating prostate cancer (PCa) initiation and progression. Identifying new downstream effectors of the androgens/AR pathway will allow a better understanding of these mechanisms and could reveal novel biomarkers and/or therapeutic agents to improve the rate of patient survival. We compared the microRNA expression profiles in androgen-sensitive LNCaP cells stimulated or not with 1 nM R1881 by performing a high-throughput reverse transcriptase-quantitative PCR and found that miR-135a was upregulated. After androgen stimulation, we showed that AR directly activates the transcription of miR-135a2 gene by binding to an androgen response element in the promoter region. Our findings identify miR-135a as a novel effector in androgens/AR signaling. Using xenograft experiments in chick embryos and adult male mice, we showed that miR-135a overexpression decreases in vivo invasion abilities of prostate PC-3 cells. Through in vitro wound-healing migration and invasion assays, we demonstrated that this effect is mediated through downregulating ROCK1 and ROCK2 expression, two genes that we characterized as miR-135a direct target genes. In human surgical samples from prostatectomy, we observed that miR-135a expression was lower in tumoral compared with paired adjacent normal tissues, mainly in tumors classified with a high Gleason score (⩾8). Moreover, miR-135a expression is lower in invasive tumors, showing extraprostatic extension, as compared with intraprostatic localized tumors. In tumor relative to normal glands, we also showed a more frequently higher ROCK1 protein expression determined using a semi-quantitative immunohistochemistry analysis. Therefore, in tumor cells, the lower miR-135a expression could lead to a higher ROCK1 protein expression, which could explain their invasion abilities. The highlighted relationship between miR-135a expression level and the degree of disease aggressiveness suggests that miR-135a may be considered as a prognostic marker in human PCa.Oncogene advance online publication, 28 July 2014; doi:10.1038/onc.2014.222.
ISSN: 0950-9232

hal-01063902
https://hal.archives-ouvertes.fr/hal-01063902
https://hal.archives-ouvertes.fr/hal-01063902/file/Androgen-regulated%20microRNA-135a.pdf
DOI : 10.1038/onc.2014.222
PUBMED : 25065599

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Growth hormone (GH) may stimulate water loss during exercise by activating sweating. This study investigated GH secretion and water loss during sequential cycling and running, taking postural changes into account. The two exercise segments had similar durations and were performed at the same relative intensity to determine their respective contributions to water loss and the plasma volume variation noted in such trials. Eight elite triathletes first performed an incremental cycle test to assess maximal oxygen consumption. Then, the triathletes performed one of two trials in randomized order: constant submaximal cycling followed by treadmill running (C 1 –R 2) or an inversed succession of running followed by cycling (R 1 –C 2). Each segment of both trials was performed for 20 minutes at ,75% of maximal oxygen consumption. The second trial, reversing the segment order of the first trial, took place two weeks later. During cycling, the triathletes used their own bicycles equipped with a profiled handlebar. Blood sampling (for GH concentrations, plasma viscosity and plasma volume variation) was conducted at rest and after each segment while water loss was estimated from the post-and pre-measures. GH increases were significantly lower in R 2 than C 2 (72.2650.1 vs. 164.06157 ng.ml 21 .min 21 , respectively; P,0.05). Water loss was significantly lower after C 1 –R 2 than R 1 –C 2 (11056163 and 12356153 ml, respectively; P,0.05). Plasma volume variation was significantly negative in C 1 and R 1 (26.1562.0 and 23.1665.0%, respectively; P,0.05), not significant in C 2 , and significantly positive for seven subjects in R 2 (4.0563.1%). We concluded that the lower GH increases in R 2 may have contributed to the smaller reduction in plasma volume by reducing sweating. Moreover, this lower GH response could be explained by the postural change during the transition from cycling to running. We recommend to pay particular attention to their hydration status during R 1 which could limit a potential dehydration during C 2 .
ISSN: 1932-6203

hal-01158212
https://hal.univ-antilles.fr/hal-01158212
DOI : 10.1371/journal.pone.0096145

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The chronostratigraphy of the lower Miocene deposits of northwestern Sardinia is refined in the Castelsardo Basin. The combination of new 40Ar/39Ar isotopic datings, 19 micropalaeontological datings (calcareous nannofossils, planktonic and large benthic foraminifers) and 16 palaeomagnetic polarity measurements led to a new chronostratigraphic framework. The continental deposits of the first megasequence (Valledoria and Casteldoria members) are possibly Aquitanian. The overlying marine sediments are early Burdigalian (Vaginella depressa Molasse). The marine transgression can be dated to around 19.7 Ma. Marine conditions ceased 18.83 ± 0.13 Ma, the age of the index aerial τ2 ignimbrite. The continental part of the second megasequence (“Lacustre” unit) is early–middle Burdigalian, between 18.8 and 18 Ma. The overlying marine part (Campulandu and Sedini members) is middle–late Burdigalian. The second marine transgression began in the earliest–late Burdigalian, during the Chron C5Dr reversal, at the time of the eustatic Bur 4 event. The Castelsardo basin went through two main extensional tectonic episodes. The first one occurred as the Valledoria Member was deposited and possibly dates back to the Aquitanian. The second one occurred as the uppermost part of the Vaginella depressa Molasse was deposited during the early Burdigalian. The second extensional episode is related to a rapid rotation of Sardinia. Palaeomagnetic results confirm that Corsica and Sardinia acted as a single block which suffered a 28 ± 17° ccw rotation after 19.2 Ma. The Castelsardo basin is held to be an Aquitanian–early Burdigalian intra-arc rift basin that later evolved in a thermally controlled subsident margin of the Ligurian-Provençal Basin during the middle–late Burdigalian.
ISSN: 0031-0182

hal-00498288
https://hal.archives-ouvertes.fr/hal-00498288
DOI : 10.1016/j.palaeo.2010.06.007

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
OBJECTIVES: To compare virological effectiveness in patients who continued on a virologically successful first-line boosted protease inhibitor (PI)-containing combination antiretroviral therapy (cART) regimen or who switched to a PI-free cART including efavirenz, nevirapine or abacavir. METHODS: From the French Hospital Database on HIV, we selected 439 patients with undetectable viral load (VL) on a first-line boosted PI-containing cART regimen who switched to a PI-free combination including efavirenz, nevirapine or abacavir. Each of these patients was matched with three patients who continued to take their first-line cART regimen, on the basis of gender, age, CD4 cell count, VL, date of cART initiation and the duration of VL undetectability. Time to virological failure (VF) was analysed with Kaplan-Meier curves and Cox models. RESULTS: The 12 month probabilities of VF were 3.7% and 5.7% in non-switch and switch patients, respectively, and 3.9%, 7.2% and 9.0% in patients switching to efavirenz-, nevirapine- and abacavir-containing cART, respectively. After adjustment, only patients switching to abacavir-containing cART had a higher risk of VF than non-switch patients (adjusted hazard ratio, 1.99; 95% confidence interval, 1.05-3.79). CONCLUSIONS: Switching from a virologically successful first-line boosted PI-containing cART regimen to a non-nucleoside reverse transcriptase inhibitor-containing cART regimen containing either efavirenz or nevirapine is virologically safe, while switching to abacavir-containing cART should be avoided.
ISSN: 0305-7453

hal-00875284
https://hal.archives-ouvertes.fr/hal-00875284
DOI : 10.1093/jac/dkr208
PUBMED : 21636583

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
The extracellular signal-regulated kinase (ERK)1/2 mitogen-activated protein (MAP) kinase pathway has been involved in the positive and negative regulation of cell proliferation. Upon mitogen stimulation, ERK1/ERK2 activation is necessary for G1- to S-phase progression whereas when hyperactived, this pathway could elicit cell cycle arrest. The mechanisms involved are not fully elucidated but a kinase-independent function of ERK1/2 has been evidenced in the MAPK-induced growth arrest. Here, we show that p70S6K, a central regulator of protein biosynthesis, is essential for the cell cycle arrest induced by overactivation of ERK1/2. Indeed, whereas MEK1 silencing inhibits cell cycle progression, we demonstrate that active mutant form of MEK1 or MEK2 triggers a G1 phase arrest by stimulating an activation of p70S6K by ERK1/2 kinases. Silencing of ERK1/2 activity by shRNA efficiently suppresses p70S6K phosphorylation on Thr421/Ser424 and S6 phosphorylation on Ser240/244 as well as p21 expression, but these effects can be partially reversed by the expression of kinase-dead mutant form of ERK1 or ERK2. In addition, we demonstrate that the kinase p70S6K modulates neither the p21 gene transcription nor the stability of the protein but enhances the translation of the p21 mRNA. In conclusion, our data emphasizes the importance of the translational regulation of p21 by the MEK1/2-ERK1/2-p70S6K pathway to negatively control the cell cycle progression. J. Cell. Physiol. 229: 903-915, 2014. © 2013 Wiley Periodicals, Inc.
ISSN: 0021-9541

hal-01061238
https://hal.archives-ouvertes.fr/hal-01061238
https://hal.archives-ouvertes.fr/hal-01061238/document
https://hal.archives-ouvertes.fr/hal-01061238/file/MEK12_OveractivationArticle_GUEGAN_JCP_2014.pdf
DOI : 10.1002/jcp.24521

Éditeur(s) : HAL CCSD
Résumé : The North Tehran Fault is located at the southernmost piedmont of Central Alborz, north of Iran. It stands out as a major active fault menacing directly the city of Tehran, a 12 million people metropolis, and would have been the source of several major historical earthquakes in the past. The fault zone extends up to 110km and corresponds mainly to a reverse fault mostly crossing the northern suburbs of the Tehran metropolis, although NTF in its eastern part is characterized more as a left lateral strike slip active fault. We carried out a paleoseismological study of the fault zone in order to determine whether the fault was activated during the Holocene, and to define the characteristics of its activity in terms of kinematics and magnitude. Here in this paper we present only a part of our paleoseismological investigations trench TE2. Observations fromtwo trenches dug across the North Tehran fault scarp reveal evidence for a maximum of six surface-rupturing events within the late quaternary. According to the empirical relationships among average displacement per event and Moment magnitude [25], we can estimate six events Mw~ 6.5 associated with these ruptures in TE2 trench.
Journal of Seismology and Earthquake Engineering

hal-00758375
https://hal.archives-ouvertes.fr/hal-00758375

Éditeur(s) : HAL CCSD
Résumé : International audience
Many different proteins self-aggregate into insoluble fibrils growing apically by reversible addition of elementary building blocks. But beyond this common principle, the modalities of fibril formation are very disparate, with various intermediate forms which can be reshuffled by minor modifications of physico-chemical conditions or amino-acid sequences. To bypass this complexity, the multifaceted phenomenon of fibril formation is reduced here to its most elementary principles defined for a linear prototype of fibril. Selected generic features, including nucleation, elongation, and conformational recruitment, are modeled using minimalist hypotheses and tools, by separating equilibrium from kinetic aspects and in vitro from in vivo conditions. These reductionist approaches allow to bring out known and new rudiments, including the kinetic and equilibrium effects of nucleation, the dual influence of elongation on nucleation, the kinetic limitations on nucleation and fibril numbers, and the accumulation of complexes in vivo by rescue from degradation. Overlooked aspects of these processes are also pointed: the exponential distribution of fibril lengths can be recovered using various models because it is attributable to randomness only. It is also suggested that the same term "critical concentration" is used for different things, involved in either nucleation or elongation
Journal of Chemical Physics

hal-01263103
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01263103
DOI : 10.1063/1.4940149
PUBMED : 26801045

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
Color polymorphism is widespread in animals and can be associated with temporary adjustments to environmental variables (phenotypic plasticity). In teleost fishes, one of the most remarkable examples of color plasticity is background adaptation in flatfishes. However, such rapid and complete changes in body color and pattern remain relatively unreported in other species. The convict surgeonfish Acanthurus triostegus is a gregarious species whose body color pattern consists of black vertical bars on a whitish body. Here, we describe an entirely reverse body color pattern (white vertical bars on a blackish body) that we observed in some A. triostegus juveniles in a nursery area at Moorea Island, French Polynesia. In aquaria, we determined that change from one color pattern to the other is rapid, reversible, and corresponds to phenotypic plasticity associated with aggressive behavior.
ISSN: 0722-4028

hal-01628304
http://hal.upmc.fr/hal-01628304
http://hal.upmc.fr/hal-01628304/document
http://hal.upmc.fr/hal-01628304/file/Besson_2017_Complete_and_rapid.pdf
DOI : 10.1007/s00338-017-1631-4

Éditeur(s) : HAL CCSD European Respiratory Society
Résumé : International audience
Telomerase reverse transcriptase (TERT) or telomerase RNA (TERC) gene mutation is a major monogenic cause of pulmonary fibrosis. Sequencing of TERT/TERC genes is proposed to patients with familial pulmonary fibrosis. Little is known about the possible predictors of this mutation and its impact on prognosis. We retrospectively analysed all the genetic diagnoses made between 2007-2014 in patients with pulmonary fibrosis. We evaluated the prevalence of TERT/TERC disease-Associated variant (DAV), factors associated with a DAV, and the impact of the DAV on survival. 237 patients with pulmonary fibrosis (153 with familial pulmonary fibrosis, 84 with telomere syndrome features without familial pulmonary fibrosis) were tested for TERT/TERC DAV. DAV was diagnosed in 40 patients (16.8%), including five with non-idiopathic interstitial pneumonia. Prevalence of TERT/TERC DAV did not significantly differ between patients with familial pulmonary fibrosis or with only telomere syndrome features (18.2% versus 16.4%). Young age, red blood cell macrocytosis, and low platelet count were associated with the presence of DAV; the probability of DAV was increased for patients 40-60 years. Transplant-free survival was lower with than without TERT/TERC DAV (4.2 versus 7.2 years; p=0.046). TERT/TERC DAV were associated with specific clinical and biological features and reduced transplantfree survival. ©ERS 2016.
ISSN: 0903-1936

hal-01467555
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01467555
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01467555/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01467555/file/Prevalence%20and%20characteristics%20of%20TERT.pdf
DOI : 10.1183/13993003.02115-2015

Éditeur(s) : HAL CCSD
Résumé : International audience
In addition to soluble factors, mechanical constraints and extracellular matrix stiffness are important regulators of cell fate that are mediated by cytoskeletal modifications. The EMT (epithelial-mesenchymal transition) that occurs during normal development and malignant progression is a typical example of the phenotypic switch associated with profound actin remodelling and changes in gene expression. For instance, actin dynamics control motile cell functions in EMT, in part, through regulating the subcellular localization of the myocardin-related transcription factor MKL1 (megakaryoblastic leukaemia translocation 1), a co-activator of SRF (serum-responsive factor). In the present paper, we show that MKL1 participates also to the control of the cellular switch between growth and quiescence. Experimental disconnection between MKL1 and G-actin (globular actin), by using an MKL1 mutant or enhancing the F (filamentous)-/G-actin ratio, generates a widely open chromatin state and a global increase in biosynthetic activity, classically associated with cell growth. Conversely, G-actin accumulation favours nuclear condensation and cell quiescence. These large-scale chromatin changes rely upon extensive histone modifications, exemplified by that of H3K9 (H3 Lys9) shifting from trimethylation, a heterochromatin mark, to acetylation, a mark of euchromatin. The present study provides the first evidence for a global reversible hetero/euchromatinization phenomenon triggered by the actin/MKL1 signalling pathway.
The Biochemical Journal

hal-01063933
https://hal.archives-ouvertes.fr/hal-01063933
DOI : 10.1042/BJ20131240
PUBMED : 24762104

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
The capacity of testicular somatic cells to promote and sustain germ cell differentiation is largely regulated by sexual steroids and notably androgens. In fish species the importance of androgens is emphasized by their ability to induce sex reversal of the developing fries and to trigger spermatogenesis. Here we studied the influence of androgens on testicular gene expression in trout testis using microarrays. Following treatment of immature males with physiological doses of testosterone or 11-ketotestosterone, 418 genes that exhibit changes in expression were identified. Interestingly, the activity of testosterone appeared stronger than that of 11-ketotestosterone. Expression profiles of responsive genes throughout testis development and in isolated germ cells confirmed androgens to mainly affect gene expression in somatic cells. Furthermore, specific clusters of genes that exhibit regulation coincidently with changes in the natural circulating levels of androgens during the reproductive cycle were highlighted, reinforcing the physiological significance of these data. Among somatic genes, a phylogenetic footprinting study identified putative androgen response elements within the proximal promoter regions of 42 potential direct androgen target genes. Finally, androgens were also found to alter the germ line towards meiotic expression profiles, supporting the hypothesis of a role for the somatic responsive genes in driving germ cell fate. This study significantly increases our understanding of molecular pathways regulated by androgens in vertebrates. The highly cyclic testicular development in trout together with functions associated with regulated genes reveal potential mechanisms for androgen actions in tubule formation, steroid production, germ cell development and sperm secretion.
ISSN: 1932-6203

inserm-00825763
http://www.hal.inserm.fr/inserm-00825763
http://www.hal.inserm.fr/inserm-00825763/document
http://www.hal.inserm.fr/inserm-00825763/file/Rolland_et_al.pdf
DOI : 10.1371/journal.pone.0053302

Éditeur(s) : HAL CCSD American Geophysical Union (AGU)
Résumé : International audience
Located east of Guadeloupe, the island of La Désirade exhibits the oldest rocks of the Lesser Antilles arc and the eastern Caribbean plate. An old magmatic basement is composed of (1) late Jurassic ophiolitic complex with meta-basaltic pillow lavas and interbedded radiolarites, (2) acid igneous complex comprising meta-quartz-diorite and meta-rhyolitic lavas flows, and (3) meta-diabasic/microdioritic dyke swarm complex. We present and discuss the discovery of synmetamorphic thrust tectonics in this island. Based on detailed structural analysis we evidenced two main compressive events. The first event (D1) is characterized by pervasive folding associated with thrust development. In the northeastern part of the island, a major thrust fault, the Grand Abaque Thrust, has been discovered which displaces for several kilometers the acid igneous complex onto the ophiolitic unit. The second deformation event (D2) is featured by a main pervasive cleavage S2 observed at the regional scale associated with upright folding (F2) and by the development of two sets of conjugated steeply dipping strike-slip shear zones, dextral 130°N and sinistral 20°N striking, respectively. Microstructural observations indicate that Greenschist facies metamorphism is clearly contemporaneous with the development of D1 and D2 superimposed tectonic structures. Ar/Ar geochronology was performed on two bulk of adularia minerals sampled in the northeast volcanic complex within a deformed zone related to a D2 event. These analyses yield well-defined and concordant plateau ages at 106.2 ± 1.7 Ma and 107.2 ± 1.8 Ma. Thus, shortening and thickening tectonics occurred during Lower Cretaceous (Albian). In the available framework of Caribbean geodynamics, the synmetamorphic thrust tectonics we discovered in the French Lesser Antilles is related to the collision between an Aptian-Albian oceanic plateau and the Andean-Cordilleran east-dipping subduction zone. Our results support subduction polarity reversal during Lower Cretaceous.
ISSN: 0278-7407

hal-00620555
https://hal.archives-ouvertes.fr/hal-00620555
DOI : 10.1029/2011TC002875

Éditeur(s) : HAL CCSD Oxford University Press (OUP): Policy C - Option B
Résumé : International audience
We report the characterization of a DNA primase/ polymerase protein (PolpTN2) encoded by the pTN2 plasmid from Thermococcus nautilus. Sequence analysis revealed that this protein corresponds to a fusion between an N-terminal domain homologous to the small catalytic subunit PriS of heterodimeric archaeal and eukaryotic primases (AEP) and a C-terminal domain related to their large regulatory subunit PriL. This unique domain configuration is not found in other virus-and plasmid-encoded primases in which PriS-like domains are typically fused to different types of helicases. PolpTN2 exhibited primase, polymerase and nucleotidyl transferase activities and specifically incorporates dNTPs, to the exclusion of rNTPs. PolpTN2 could efficiently prime DNA synthesis by the T. nautilus PolB DNA polymerase, suggesting that it is used in vivo as a primase for pTN2 plasmid replication. The N-terminal PriS-like domain of PolpTN2 exhibited all activities of the full-length enzyme but was much less efficient in priming cellular DNA polymerases. Surprisingly, the N-terminal domain possesses reverse transcriptase activity. We speculate that this activity could reflect an ancestral function of AEP proteins in the transition from the RNA to the DNA world.
ISSN: 0305-1048

Droits : http://creativecommons.org/licenses/by/
hal-01332620
http://hal.upmc.fr/hal-01332620
http://hal.upmc.fr/hal-01332620/document
http://hal.upmc.fr/hal-01332620/file/Nucl.%20Acids%20Res.-2014-Gill-3707-19.pdf
DOI : 10.1093/nar/gkt1385

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
Anisotropy of low-field magnetic susceptibility (AMS) of basaltic lava flows can give some clues about post-emplacement tilting occurring in volcanic sequences. Such a study has been carried out on a sequence of 19 successive lava flows from Kerguelen Archipelago. Surprisingly, two different patterns were observed. The first one - herein called normal fabric - is consistent with the lava-flow direction inferred from geological observations, whereas the second one observed for about 70 per cent of the analysed samples - herein called abnormal fabric - appears to be unrelated to the shear history of the lava flows during their emplacements. These abnormal fabrics are not strictly inverse fabric but seem to have a more complex origin. The unusual nature of these abnormal fabrics has been confirmed by lattice preferred orientation of plagioclases obtained from high-resolution electron backscattered diffraction measurements. The aim of this study is to propose a physical interpretation of these fabrics. A first step in our understanding was to clearly identify the nature and the magnetic properties of the Fe-Ti oxides assemblage. Thus, we present a comprehensive rock magnetic analysis relying on low- and high-temperature thermomagnetic curves (K-T), crossover diagrams, first-order reversal curves, ore-microscopy, Mössbauer measurements and electron backscattered images. We found that in the present case the abnormal fabrics are probably linked to a mixture of prevailing single domain (SD) strongly interacting grains population and a subsidiary multidomain grains population. SD grains are identified as small magnetite crystallized within the interstitial glass in globular aggregates along the silicate framework. Then a question arises: to what extent such SD interacting grains in globular aggregates can affect the magnetic susceptibility and its anisotropy? To answer this question, we developed a physical model in which the total energy density of an SD grain with an uniaxial anisotropy is minimized. In this model, the distribution function of the direction of the magnetic interaction field is comprised between two boundary states. It is either isotropic, which formally corresponds to the thermal demagnetized state, or it is ordered, which formally corresponds to the Alternative Field demagnetized state. We show that in both cases the degree of anisotropy decreases as the interaction field increases. Thus, we conclude that the abnormal fabric encountered in this study can be simply explained by strong magnetostatic interactions that would explain the large scattering of AMS often observed in basaltic lava flows.
ISSN: 0956-540X

hal-00716449
https://hal.archives-ouvertes.fr/hal-00716449
https://hal.archives-ouvertes.fr/hal-00716449/document
https://hal.archives-ouvertes.fr/hal-00716449/file/gji-S-12-HAL.pdf
DOI : 10.1111/J.1365-246X.2012.05421.X

Éditeur(s) : Elsevier
Résumé : injection of non-specific dsRNA initiates a broad-spectrum innate antiviral immune response in the Pacific white shrimp, Litopenaeus vannamei, however, the receptor involved in recognition of this by-product of viral infections remains unknown. In vertebrates, dsRNA sensing is mediated by a class of Toll-like receptors (TLRs) and results in activation of the interferon system. Because a TLR (lToll) was recently characterized in L. vannamei, we investigated its potential role in dsRNA recognition. We showed that injection of non-specific RNA duplexes did not modify lToll gene expression. A reverse genetic approach was therefore implemented to study its role in vivo. Silencing of lToll did not impair the ability of nonspecific dsRNA to trigger protection from white spot syndrome virus and did not increase the shrimp susceptibility to viral infection, when compared to controls. In contrast, gene-specific dsRNA injected to specifically silence lToll expression activated an antiviral response. These data strongly suggest that shrimp lToll plays no role in dsRNA-induced antiviral immunity. (C) 2009 Elsevier Ltd. All rights reserved.
Developmental & Comparative Immunology (0145-305X) (Elsevier), 2009-07 , Vol. 33 , N. 7 , P. 806-810

Droits : 2009 Elsevier Ltd All rights reserved.
http://archimer.ifremer.fr/doc/2009/publication-6428.pdf
DOI:10.1016/j.dci.2009.02.005
http://archimer.ifremer.fr/doc/00000/6428/

Éditeur(s) : HAL CCSD American Geophysical Union
Résumé : International audience
We present the results of a paleomagnetic study of seven new volcanic sections (146 flows) from Kerguelen Archipelago. For two of these sections, preliminary (;40;Ar/;39;Ar) ages are reported to aid in the calibration of the paleomagnetic results. The primary contribution of this report, however, is a compilation of these new data with those already published in order to describe statistically the characteristics of the paleomagnetic field as recorded by the Kerguelen flood basalts. In total, 258 paleomagnetic directions sampled at 13 stratigraphic sections through the lava pile are available and span an approximately 5 Ma window: from 25 to 30 Ma. The composite section represents at least 11 polarity zones that are correlated to the reference geomagnetic polarity timescale. Our approach is to investigate the average normal and reversed polarity field directions over this 5 Ma window. We calculated a paleomagnetic pole found to be located at ;λ; = 85.5°N, = 189.3°E (A;95; = 2.3°, K = 16.5, N = 233). This pole is in close agreement with the coeval paleomagnetic poles obtained from different worldwide places when analyzed in the Indo-Atlantic hot spot reference frame. In the statistical analysis we tackle the specific question: Is the secular variation isotropic? This question is directly related to the occurrence of a longitudinal confinement of the virtual geomagnetic poles, which is still a matter of debate among paleomagnetists. By means of statistical tests we show that the paleomagnetic data from Kerguelen agree with an isotropic model for paleosecular variation. Finally, we present adjustments to Camps and Prévot's (1996) statistical model, developed for some Northern Hemisphere latitudes, to the Southern Hemisphere paleomagnetic data from Kerguelen.
ISSN: 0148-0227

hal-00407636
https://hal.archives-ouvertes.fr/hal-00407636
https://hal.archives-ouvertes.fr/hal-00407636/document
https://hal.archives-ouvertes.fr/hal-00407636/file/pcamps-JGR2007.pdf
DOI : 10.1029/2006JB004648

Éditeur(s) : HAL CCSD
Résumé : Guadeloupe Island (West French Indies) is one of the twenty islands that compose the Lesser Antilles Arc, which results from the subduction of the Atlantic Ocean plate beneath the Caribbean one. The island lies in a complex volcano-tectonic system and the need to understand its geological context has led to numerous on- and offshore geophysical investigations. This work presents the compilation and processing of available, on-land, airborne and marine, gravity and magnetic data acquired during the last 40 years on Guadeloupe Islands and at the scale of the Lesser Antilles Arc. The overall dataset provides new Bouguer and reduced to the pole magnetic anomaly maps at the highest achievable resolution. Regionally, the main central negative gravity trend of the arc allows defining two subsident areas. The first one is parallel to the arc direction (~N160°E) to the north, whereas the second unexpected southern one is oriented parallel to oceanic ridges (N130°E). Along the Outer Arc, the long wavelength positive anomaly is interpreted, at least along the Karukera Spur, as an up-rise of the volcanic basement in agreement with the seismic studies. To the NE of Guadeloupe, the detailed analysis of the geophysical anomalies outlines a series of structural discontinuities consistent with the main bathymetric morphologies, and in continuity of the main fault systems already reported in this area. Based on geophysical evidences, this large scale deformation and faulting of the Outer Arc presumably primarily affects the Atlantic subducting plate and secondarily deforms the upper Caribbean plate and the accretion prism. At the scale of Guadeloupe Island, joined gravity and magnetic modeling has been initiated based on existing interpretation of old seismic refraction profiles, with a general structure in three main layers. According to our geophysical anomalies, additional local structures are also modeled in agreement with geological observations: i) the gravity and magnetic signals confirm an up-rise of the volcanic basement below the limestone platforms outcropping on Grande-Terre Island ; ii) the ancient volcanic complexes of Basse-Terre Island are modeled with high density and reverse magnetized formations; iii) the recent volcanic centre is associated with formations consistent with the low measured density and the underlying hydrothermal system. The EW models coherently image a NNW-SSE depression structure in half-graben beneath Basse-Terre Island, its western scarp following the arc direction in agreement with bathymetric and seismic studies to the north of the island. The so-defined depressed area, and particularly its opening in half-graben toward the SW, is interpreted as the present-day front of deformation of the upper plate associated with the recent volcanic activity on and around Guadeloupe. Based on this regional deformation model, perspectives are given for further integrated investigation of key targets to address the internal structure and evolution of the Lesser Antilles Arc and Guadeloupe volcanic system.
Colloque 2012 du Comité National Français de Géodésie et Géophysique (CNFGG)
Clermont-Ferrand, France

hal-00742653
https://hal-brgm.archives-ouvertes.fr/hal-00742653
https://hal-brgm.archives-ouvertes.fr/hal-00742653/document
https://hal-brgm.archives-ouvertes.fr/hal-00742653/file/CNFGG_Caraibes.pdf

Éditeur(s) : HAL CCSD American Geophysical Union
Résumé : International audience
After the January 12, 2010, Haiti earthquake, we deployed a mainly offshore temporary network of seismologic stations around the damaged area. The distribution of the recorded aftershocks, together with morphotectonic observations and mainshock analysis, allow us to constrain a complex fault pattern in the area. Almost all of the aftershocks have a N‐S compressive mechanism, and not the expected left‐lateral strike‐slip mechanism. A first‐order slip model of the mainshock shows a N264°E north‐dipping plane, with a major left‐lateral component and a strong reverse component. As the aftershock distribution is sub‐parallel and close to the Enriquillo fault, we assume that although the cause of the catastrophe was not a rupture along the Enriquillo fault, this fault had an important role as a mechanical boundary. The azimuth of the focal planes of the aftershocks are parallel to the north‐dipping faults of the Transhaitian Belt, which suggests a triggering of failure on these discontinuities. In the western part, the aftershock distribution reflects the triggering of slip on similar faults, and/or, alternatively, of the south‐dipping faults, such the Trois‐Baies submarine fault. These observations are in agreement with a model of an oblique collision of an indenter of the oceanic crust of the Southern Peninsula and the sedimentary wedge of the Transhaitian Belt: the rupture occurred on a wrench fault at the rheologic boundary on top of the under‐thrusting rigid oceanic block, whereas the aftershocks were the result of the relaxation on the hanging wall along pre‐existing discontinuities in the frontal part of the Transhaitian Belt.
ISSN: 0094-8276

insu-00643489
https://hal-insu.archives-ouvertes.fr/insu-00643489
https://hal-insu.archives-ouvertes.fr/insu-00643489/document
https://hal-insu.archives-ouvertes.fr/insu-00643489/file/GRL-haiti.2011.pdf
DOI : 10.1029/2011GL049799

Éditeur(s) : HAL CCSD
Résumé : The territory of Armenia was located in the collision zone between Arabia and Eurasia, and is the seat of active intercontinental deformations, which was attested by the many historical earthquakes that have occurred in this region. All these destructive earthquakes show a strong regional seismic activity, and therefore it is important to evaluate the seismic hazard associated with active structures that generates this seismicity.This study presents the results of the analysis of the active tectonics within the northwestern and southeastern extensions of the Pambak-Sevan-Syunik fault (PSSF), a major right-lateral strike-slip fault cutting through Armenia (NW - SE). Quantifying the deformations in terms of geometry, kinematics, slip rates and earthquake activity, using cosmogenic 3He, OSL/IRSL and radiocarbon dating techniques, reveal different behaviors between the two regions.Within the northwestern extension, in the region of Amassia, the PSSF bends to the west and splits into two main WNW-ESE trending reverse faults defining a compressional pop-up structure. We estimate an uplift rate and a shortening rate of 0.5 ± 0.1 mm/y and 1.4 ± 0.6 mm/y, respectively. This suggests that most of the ~2 mm/y right lateral movement of the PSSF seems to be absorbed within the Amasia pop-structure.Within the southeastern extension, in the region of Tsghuk volcano, the PSSF shows signs of dying out at the southernmost tip of the Syunik graben. A very slow NS trending normal faulting associated with a slight right-lateral movement characterizes the tectonic activity in the region of Tsghuk volcano. We estimate vertical slip rates, EW stretching rate, and right-lateral slip rate of ~0.2 mm/y, ~0.1 mm/y and ~0.05 mm/y, respectively. These results lead to the conclusion that the right lateral movement observed further north along the PSSF is mainly transferred within other active faults further west within the Karabagh (Hagari fault or other structures further northwestwards).
L’Arménie se situe dans la zone de collision entre Arabie et Eurasie et est le siège d’une déformation intracontinental active comme l’atteste les nombreux tremblements de terre historiques qui s’y sont produits. Tous ces séismes, destructeurs, attestent d’une forte activité sismique régionale, et il est par conséquent important d'évaluer l’aléa sismique associé aux structures actives qui génère cette sismicité.Le travail présenté ici, expose les résultats de l’analyse de la tectonique active au niveau des terminaisons nord-ouest et sud-est de la faille de Pambak-Sevan-Syunik (PSSF), une des failles décrochant majeure qui traverse l'Arménie du NW au SE. La quantification des déformations en termes de géométrie, cinématique, vitesse de glissement et paléosismicité, en utilisant les méthodes de datation 3He cosmogénique, OSL/IRSL et radiocarbone, révèlent des comportements différents entre les deux régions.Au niveau de la terminaison nord-ouest, dans la région d’Amassia, la faille PSSF s’incurve vers l'ouest et se subdivise en deux branches de direction WNW-ESE, et de cinématique inverse, définissant une structure en pop-up. Nous estimons une vitesse de soulèvement de 0.5 ± 0.1 mm/an et une vitesse de raccourcissement NNE-SSW de 1.4 ± 0.6 mm/an. Ces résultats suggère que l’essentiel des ~2 mm/an de mouvement dextre estimés le long de la faille de PSSF sont absorbés au niveau du pop-up d’Amassia.Au niveau de la terminaison sud-est, dans la région du volcan Tsghuk, la faille PSSF semble disparaitre. Le peu d’activité tectonique est caractérisée par des failles normales sub-méridiennes associées à une légère composante décrochant dextre. Nous déterminons une vitesse de glissement vertical de ~0,2 mm/an, une vitesse d’extension ~EW de ~0,1 mm/an associée à une composante dextre de ~0,05 mm/an. Ces résultats suggèrent que le mouvement dextre observé le long de la faille de PSSF plus au nord, a été transféré sur d'autres failles plus à l'ouest dans le Karabakh (faille Hagari ou autres structures situés encore plus au NW).
https://tel.archives-ouvertes.fr/tel-01621440

NNT : 2016MONTT152
tel-01621440
https://tel.archives-ouvertes.fr/tel-01621440
https://tel.archives-ouvertes.fr/tel-01621440v2/document
https://tel.archives-ouvertes.fr/tel-01621440/file/2016_MKRTCHYAN_archivage.pdf