Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
127 patients from Tahiti who were suffering from elephantiasis were interviewed about their opinion of the origin of their disease. Ancestral beliefs are still widely held even after 25 years of antifilarial campaigns which have resulted in a drastic decrease in endemicity with almost no clinical incidence. It is disappointing that the responsibility of mosquitoes is denied by a majority of patients. The explanations are to be found in the unusual evolution of this disease and in the small importance attached to sanitary education.
ISSN: 0035-9203

hal-00715426
https://hal.univ-antilles.fr/hal-00715426
PUBMED : 45325

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
We use 3 yr of surface absolute gravity measurements at three sites on the Larzac plateau (France) to quantify the changes induced by topography and the building on gravity time-series, with respect to an idealized infinite slab approximation. Indeed, local topography and buildings housing ground-based gravity measurement have an effect on the distribution of water storage changes, therefore affecting the associated gravity signal. We first calculate the effects of surrounding topography and building dimensions on the gravity attraction for a uniform layer of water. We show that a gravimetric interpretation of water storage change using an infinite slab, the so-called Bouguer approximation, is generally not suitable. We propose to split the time varying gravity signal in two parts (1) a surface component including topographic and building effects (2) a deep component associated to underground water transfer. A reservoir modelling scheme is herein presented to remove the local site effects and to invert for the effective hydrological properties of the unsaturated zone. We show that effective time constants associated to water transfer vary greatly from site to site. We propose that our modelling scheme can be used to correct for the local site effects on gravity at any site presenting a departure from a flat topography. Depending on sites, the corrected signal can exceed measured values by 5-15 μGal, corresponding to 120-380 mm of water using the Bouguer slab formula. Our approach only requires the knowledge of daily precipitation corrected for evapotranspiration. Therefore, it can be a useful tool to correct any kind of gravimetric time-series data.
ISSN: 0956-540X

hal-00795590
https://hal.archives-ouvertes.fr/hal-00795590
DOI : 10.1093/gji/ggs007

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
Persistent organic pollutants have not been conclusively associated with length of gestation or with preterm birth. Chlordecone is an organochlorine pesticide that has been extensively used to control the banana root borer population in the French West Indies. Data from the Timoun Mother-Child Cohort Study conducted in Guadeloupe between 2004 and 2007 were used to examine the associations of chlordecone concentrations in maternal plasma with the length of gestation and the rate preterm birth in 818 pregnant women. Data were analyzed using multivariate linear regression for length of gestation and a Cox model for preterm birth. The median plasma chlordecone concentration was 0.39 µg/L (interquartile range, 0.18-0.83). No correlation was observed with plasma concentrations of p,p'-dichlorodiphenyl dichloroethene (ρ = 0.017) or polychlorinated biphenyl 153 (ρ = -0.016), the other main organochlorine compounds detected. A 1-log10 increase in chlordecone concentration was associated with a decreased length of gestation (-0.27 weeks; 95% confidence interval: -0.50, -0.03) and an increased risk of preterm birth (60%; 95% confidence interval: 10, 130). These associations may result from the estrogen-like and progestin-like properties of chlordecone. These results are of public health relevance because of the prolonged persistence of chlordecone in the environment and the high background rate of preterm births in this population.
ISSN: 0002-9262

hal-01010740
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01010740
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01010740/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01010740/file/Chlordecone%20Exposure%20final.pdf
DOI : 10.1093/aje/kwt313

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
Energy dissipation is observed on seismic data when a wave propagates through a porous medium, involving different frequency regimes depending on the nature of rock and fluid types. We focus here on the role of partial fluid saturation in unconsolidated porous media, looking in particular at P-wave phase velocity and attenuation. The study consists in running an experiment in a sand-filled tank partially saturated with water. Seismic propagation in the tank is generated in the kHz range by hitting a steel ball on a granite plate. Seismic data are recorded by buried accelerometers and injecting or extracting water controls the partial saturation. Several imbibition/drainage cycles were performed between the water and gas residual saturations. A Continuous Wavelet Transform applied on seismic records allowed us to extract the direct P-wave at each receiver.We observe an hysteresis in phase velocities and inverse quality factors between imbibition and drainage. Phase velocities and inverse quality factors are then jointly inverted to get a final poro-visco-elastic model of the partially saturated sand that satisfactorily reproduces the data. The model formulation consists in generalizing the Biot theory to effective properties of the fluid and medium (permeability and bulk modulus) in order to properly explain the phase velocity variation as a function of the saturation. The strong level of attenuation measured experimentally is further explained by an anelastic effect due to grain to grain sliding, adding to Biot's losses. This study shows that fluid distribution at microscopic scale has strong influence on the attenuation of direct P-waves at macroscopic scale and confirms that seismic prospection may be a powerful tool for the characterization of transport phenomena in porous media.
ISSN: 0956-540X

hal-00779920
https://hal.archives-ouvertes.fr/hal-00779920
https://hal.archives-ouvertes.fr/hal-00779920/document
https://hal.archives-ouvertes.fr/hal-00779920/file/Barriere_et_al_HAL.pdf
DOI : 10.1111/j.1365-246X.2012.05691.x

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
STUDY QUESTION: Do mild analgesics affect the endocrine system of the human adult testis? SUMMARY ANSWER: Mild analgesics induce multiple endocrine disturbances in the human adult testis in vitro. WHAT IS KNOWN ALREADY: Mild analgesics have recently been incriminated as potential endocrine disruptors. Studies of the effects of these widely used molecules on the androgenic status of men are limited and somewhat contradictory. This prompted us to investigate whether these compounds could alter the adult human testicular function. We therefore assessed in parallel the effects of paracetamol, aspirin and indomethacin on organo-cultured adult human testis and on the NCI-H295R steroid-producing human cell line. STUDY DESIGN, SIZE, DURATION: Adult human testis explants or NCI-H295R adrenocortical human cells were cultured with 10(-4) or 10(-5) M paracetamol, aspirin or indomethacin for 24-48 h. The effect of 10(-5) M ketoconazole, used as an anti-androgenic reference molecule, was also assessed. PARTICIPANTS/MATERIALS, SETTING, METHODS: Testes were obtained from prostate cancer patients, who had not received any hormone therapy. The protocol was approved by the local ethics committee of Rennes, France and informed consent was given by the donors. Only testes displaying spermatogenesis, as assessed by transillumination, were used in this study. Hormone levels in the culture media were determined by radioimmunoassay (testosterone, insulin-like factor 3), Enzyme-Linked Immunosorbent Assay (inhibin B) or Enzyme Immunosorbent Assay [prostaglandin (PG) D2, and PGE2]. Tissues were observed and cells counted using classical immunohistochemical methods. MAIN RESULTS AND THE ROLE OF CHANCE: The three mild analgesics caused multiple endocrine disturbances in the adult human testis. This was particularly apparent in the interstitial compartment. Effective doses were in the same range as those measured in blood plasma following standard analgesic treatment. The production of testosterone and insulin-like factor 3 by Leydig cells was altered by exposure to all these drugs. Inhibin B production by Sertoli cells was marginally affected by aspirin only. Our experiments also revealed that mild analgesics display direct anti-PG activity, which varied depending on the drug used, the dose and the duration of exposure. Nevertheless, associations between the alteration of the PG and testosterone profiles were not systematically observed, suggesting that a combination of mechanisms of endocrine disruption is at play. LIMITATIONS, REASONS FOR CAUTION: Our studies were performed in vitro. WIDER IMPLICATIONS OF THE FINDINGS: We provide the first evidence that direct exposure to mild analgesics can result in multiple endocrine disturbances in the human adult testis. Caution, concerning the consumption of mild analgesics by men, should be strengthened, particularly in high-risk population subgroups such as elite athletes.
ISSN: 0268-1161

inserm-00866016
http://www.hal.inserm.fr/inserm-00866016
PUBMED : 23670170
DOI : 10.1093/humrep/det112

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
To estimate the seismic hazard, the geometry (dip, length and orientation) and the dynamics (type of displacements and amplitude) of the faults in the area of interest need to be understood. In this paper, in addition to geomorphologic observations, we present the results of two ground penetrating radar (GPR) campaigns conducted in 2010 and 2011 along the Emeelt fault in the vicinity of Ulaanbaatar, capital of Mongolia, located in an intracontinental region with low deformation rate that induces long recurrence time between large earthquakes. As the geomorphology induced by the fault activity has been highly smoothed by erosion processes since the last event, the fault location and geometry is difficult to determine precisely. However, by using GPR first, a non-destructive and fast investigation, the fault and the sedimentary deposits near the surface can be characterized and the results can be used for the choice of trench location. GPR was performed with a 50 MHz antenna over 2-D lines and with a 500 MHz antenna for pseudo-3-D surveys. The 500 MHz GPR profiles show a good consistency with the trench observations, dug next to the pseudo-3-D surveys. The 3-D 500 MHz GPR imaging of a palaeochannel crossed by the fault allowed us to estimate its lateral displacement to be about 2 m. This is consistent with a right lateral strike-slip displacement induced by an earthquake around magnitude 7 or several around magnitude 6. The 2-D 50 MHz profiles, recorded perpendicular to the fault, show a strong reflection dipping to the NE, which corresponds to the fault plane. Those profiles provided complementary information on the fault such as its location at shallow depth, its dip angle (from 23 • to 35 •) and define its lateral extension. Central Asia is known for its high level of seismic hazards, especially Mongolia, which has been one of the most seismically active intracontinental regions in the world with four large earthquakes (magnitude around 8) along its active faults in the western part of the country during the last century (Khilko et al. 1985). The deformation in Mongolia is located between compressive structures related to the collision and penetration of the Indian plate into the Eurasian plate and extensive structures in the north of the country related with the Baykal rift (Tapponnier & Molnar 1979; Baljinnyam et al. 1993; Schlupp 1996; Bayasgalan & Jackson 1999). The seismic activity observed in the vicinity of Ulaanbaatar (UB), capital of Mongolia, is relatively low compared to the activity observed in western Mongolia. Nevertheless, since 2005, the seismic activity around UB not only has increased, but is also organized (see Fig. 1) at the west of UB along two perpendicular directions, which determine two active faults: Emeelt fault, discovered in 2008 (NNW-SSE direction, 25-km-long minimum and situated about 10 km W of UB) and Hustai fault (WSW–ENE direction, 80 km long, with its NE tip at less than 20 km west of UB); their length and morphology indicate that they can produce earthquakes of magnitude 6.5–7.5 (Schlupp et al. 2012). Most of the Mongolian population (1.2 million over 3 million) is concentrated at UB, which is the main political and economical centre of the country. Hence, the study of seismic hazard and the estimation of the probability of future destructive earthquakes are of primary importance for the country (Dugarmaa et al. 2006). Since the last large earthquake, the faults geomorphology has been highly smoothed by erosional processes and the exact location of the fault plane surface rupture is thus hidden within a several metre wide strip. The GPR method has been proven to give good and useful results to characterize faults by identifying offsets of radar reflections (Malik et al. 2007; Christie et al. 2009; Yalçiner et al. 2013) and
ISSN: 0956-540X

hal-01342629
https://hal.archives-ouvertes.fr/hal-01342629
https://hal.archives-ouvertes.fr/hal-01342629/document
https://hal.archives-ouvertes.fr/hal-01342629/file/Dujardin_Bano_etal_Geoph.%20J.%20Int._2014_final.pdf
DOI : 10.1093/gji/ggu130

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
ISSN: 0022-1899

hal-01123839
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01123839
DOI : 10.1093/infdis/jiv129
PUBMED : 25737560

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
Functional ecology has long considered the support function as important, but its biomechanical complexity is only just being elucidated. We show here that it can be described on the basis of four biomechanical traits, two safety traits against winds (SW) and self-buckling (SB), and two motricity traits involved in sustaining an upright position, tropic motion velocity (MV) and posture control (PC). All these traits are integrated at the tree scale, combining tree size and shape together with wood properties. The assumption of trait constancy has been used to derive allometric scaling laws, but it was more recently found that observing their variations among environments and functional groups, or during ontogeny, provides more insights into adaptive syndromes of tree shape and wood properties. However, over-simplified expressions have often been used, possibly concealing key adaptive drivers. An extreme case of over-simplification is the use of wood basic density as a proxy for safety. Actually, since wood density is involved in stiffness, loads and construction costs, the impact of its variations on safety is non-trivial. Moreover, other wood features, especially the microfibril angle (MFA), are also involved. Furthermore, wood is not only stiff and strong, but it also acts as a motor for MV and PC. The relevant wood trait for that is maturation strain asymmetry. Maturation strains vary with cell wall characteristics such as MFA, rather than with wood density. Finally, the need for further studies about the ecological relevance of branching patterns, motricity traits and growth responses to mechanical loads is discussed.
ISSN: 0022-0957

hal-00909904
https://hal.archives-ouvertes.fr/hal-00909904
https://hal.archives-ouvertes.fr/hal-00909904/document
https://hal.archives-ouvertes.fr/hal-00909904/file/Integrative_biomechanics_for_tree_Fournier_al.pdf
DOI : 10.1093/jxb/ert279

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
Sensitive instruments like strainmeters and tiltmeters are necessary for measuring slowly varying low amplitude Earth deformations. Nonetheless, laser and fibre interferometers are particularly suitable for interrogating such instruments due to their extreme precision and accuracy. In this paper, a practical design of a simple pendulum borehole tiltmeter based on laser fibre interferometric displacement sensors is presented. A prototype instrument has been constructed using welded borosilicate with a pendulum length of 0.85 m resulting in a main resonance frequency of 0.6 Hz. By implementing three coplanar extrinsic fibre Fabry-Perot in-terferometric probes and appropriate signal filtering, our instrument provides tilt measurements that are insensitive to parasitic deformations caused by temperature and pressure variations. This prototype has been installed in an underground facility (Rustrel, France) where results show accurate measurements of Earth strains derived from Earth and ocean tides, local hydro-logic effects, as well as local and remote earthquakes. The large dynamic range and the high sensitivity of this tiltmeter render it an invaluable tool for numerous geophysical applications such as transient fault motion, volcanic strain and reservoir monitoring.
ISSN: 0956-540X

hal-01265967
https://hal.archives-ouvertes.fr/hal-01265967
https://hal.archives-ouvertes.fr/hal-01265967/document
https://hal.archives-ouvertes.fr/hal-01265967/file/HCS1.pdf
DOI : 10.1093/gji/ggv358

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
OBJECTIVES: To compare virological effectiveness in patients who continued on a virologically successful first-line boosted protease inhibitor (PI)-containing combination antiretroviral therapy (cART) regimen or who switched to a PI-free cART including efavirenz, nevirapine or abacavir. METHODS: From the French Hospital Database on HIV, we selected 439 patients with undetectable viral load (VL) on a first-line boosted PI-containing cART regimen who switched to a PI-free combination including efavirenz, nevirapine or abacavir. Each of these patients was matched with three patients who continued to take their first-line cART regimen, on the basis of gender, age, CD4 cell count, VL, date of cART initiation and the duration of VL undetectability. Time to virological failure (VF) was analysed with Kaplan-Meier curves and Cox models. RESULTS: The 12 month probabilities of VF were 3.7% and 5.7% in non-switch and switch patients, respectively, and 3.9%, 7.2% and 9.0% in patients switching to efavirenz-, nevirapine- and abacavir-containing cART, respectively. After adjustment, only patients switching to abacavir-containing cART had a higher risk of VF than non-switch patients (adjusted hazard ratio, 1.99; 95% confidence interval, 1.05-3.79). CONCLUSIONS: Switching from a virologically successful first-line boosted PI-containing cART regimen to a non-nucleoside reverse transcriptase inhibitor-containing cART regimen containing either efavirenz or nevirapine is virologically safe, while switching to abacavir-containing cART should be avoided.
ISSN: 0305-7453

hal-00875284
https://hal.archives-ouvertes.fr/hal-00875284
DOI : 10.1093/jac/dkr208
PUBMED : 21636583

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
Two types of olivine occur in kimberlites from Greenland, Canada and southern Africa. The first, xenocrystic olivine, displays several different forms. Most distinctive are 'nodules', a term we use to describe the large (1-5 mm), rounded, single crystals or polycrystalline aggregates that are a common constituent of many kimberlites. Olivine compositions are uniform within single nodules but vary widely from nodule to nodule, from Fo81 to 93. Within many nodules, sub- to euhedral asymmetric tablets have grown within larger anhedral olivine grains. Dislocation structures, particularly in the anhedral grains, demonstrate that this olivine was deformed before being incorporated into the kimberlite magma. Olivine grains in the kimberlite matrix between the nodules have morphologies similar to those of the tablets, suggesting that most matrix olivine grains are parts of disaggregated nodules. We propose that a sub- to euhedral form is not sufficient to identify phenocrysts in kimberlites and provide some criteria, based on morphology, internal deformation and composition, that distinguish phenocrysts from xenocrysts. The second type of olivine is restricted to rims surrounding xenocrystic grains. Only this olivine crystallized from the kimberlite magma. Major and trace element data for the rim olivine are used to calculate the composition of the parental kimberlite liquid, which is found to contain between about 20 and 30% MgO. The bulk compositions of many kimberlites contain higher MgO contents as a result of the presence of xenocrystic olivine. The monomineralic, dunitic, character of the nodules, and the wide range from Fo-rich to Fo-poor olivine compositions, provide major constraints on the origin of the nodules. Dunite is a relatively rare rock in the mantle and where present its olivine is persistently Fo-rich. The dunitic source of the nodules in kimberlites lacked minerals such as pyroxene and an aluminous phase, which make up about half of most mantle-derived rocks. It appears that these minerals were removed from the mantle peridotite that was to become the source of the nodules, and the Fo content of the retained olivine was modified during interaction with CO2-rich fluids whose arrival at the base of the lithosphere immediately preceded the passage of the kimberlite magmas. Fragments of the resultant dunite were entrained into the kimberlite, where they were retained both as intact nodules and as disaggregated grains in the matrix.
ISSN: 0022-3530

insu-00543321
https://hal-insu.archives-ouvertes.fr/insu-00543321
BIBCODE : 10.1093/petrology/egp080
DOI : 10.1093/petrology/egp080

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
The processes active in the deep crust above an oceanic subduction zone during its evolution have been constrained through a detailed geochemical study (major and trace elements and Sr, Nd and Pb isotopes) of representative samples through an 30 km thick exhumed crustal section of the Cretaceous Kohistan oceanic island arc (Northern Pakistan). The use of both trace elements and radiogenic isotopes reveals two distinct geochemical suites (suites A and B) within the JijalPatanKiruKamila (JPKK) complex. Suite A is characterized by a progressive enrichment in Pb-207 and a decrease in Nd-143/Nd-144 with increasing La-N/Sm-N. Suite B has higher Pb-207/Pb-204 and lower Nd-143/Nd-144 ratios with approximately constant La-N/Sm-N. By combining trace elements with different partitioning behaviour it is demonstrated that there is an increasing contribution of the subduction component in the magmas with time. It is also possible to distinguish a slab component imprint carried by aqueous fluids from one corresponding to sediment melts. Intrusive granites are abundant in the upper levels of the JPKK section. All were generated at the arc root level (Jijal crustal section) during dehydration-melting of hornblende-rich plutonic rocks. A three-stage geodynamic model is proposed for the evolution of the arc over a period of 30 Myr. The first stage (117105 Ma) starts with the onset of subduction, which was followed by the building of the volcanic arc. The second stage (10599 Ma to 9691 Ma) corresponds to a major igneous event, which was characterized by abundant magma underplating and granulite-facies metamorphism at the arc base. Recycling of the residualcumulative lower crust into the convective asthenospheric mantle was efficient during this stage, and was probably related to thermo-mechanical erosion of the base of the crust. The last stage (9585 Ma) corresponds to a period of low magmatic activity, which marked the end of the intra-oceanic subduction. This is related to the formation of a cold blanket above the slab surface as a result of thermo-mechanical erosion of the cold walls of the subduction zone (i.e. the upper part of the slab and the base of the overriding plate), and corner flow dragging the cold material into the zone of melt generation. Ultimately, a voluminous magmatic pulse occurred around 85 Ma (forming the Chilas complex), before arccontinent collision.
ISSN: 0022-3530

hal-00420068
https://hal.archives-ouvertes.fr/hal-00420068
DOI : 10.1093/petrology/egp010

Éditeur(s) : HAL CCSD Oxford University Press (OUP): Policy B - Oxford Open Option B
Résumé : Variability of leaf traits related to photosynthesis was assessed in seedlings from 14 tree species growing in the tropical rain forest of French Guiana. Leaf photosynthetic capacity (maximum rate of carboxylation and maximum rate of electron transport) was estimated by fitting a biochemical model of photosynthesis to response curves of net CO2 assimilation rate versus intercellular CO2 mole fraction. Leaf morphology described by leaf mass per unit leaf area (LMA), density and thickness, as well as area- and mass-based nitrogen (N) and carbon (C) concentrations, were recorded on the same leaves. Large interspecific variability was detected in photosynthetic capacity as well as in leaf structure and leaf N and C concentrations. No correlation was found between leaf thickness and density. The correlations between area- and massbased leaf N concentration and photosynthetic capacity were poor. Conversely, the species differed greatly in relativeNallocation to carboxylation and bioenergetics. Principal component analysis (PCA) revealed that, of the recorded traits, only the computed fraction of total leafNinvested in photosynthesis was tightly correlated to photosynthetic capacity.We also used PCAto test to what extent species with similar shade tolerances displayed converging leaf traits related to photosynthesis. No clear-cut ranking could be detected among the shade-tolerant groups, as confirmed by a one-way ANOVA.We conclude that the large interspecific diversity in photosynthetic capacity was mostly explained by differences in the relative allocation of N to photosynthesis and not by leafNconcentration, and that leaf traits related to photosynthetic capacity did not discriminate shade-tolerance ranking of these tropical tree species.
ISSN: 0829-318X

hal-01031522
https://hal.archives-ouvertes.fr/hal-01031522

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
Tilt fluctuations can potentially reflect the response of hydrosystems to important rainfall. In this context, long baseline tiltmeters have been installed in an underground tunnel penetrating the Fontaine de Vaucluse karst to study the medium deformation related to solicitations exerted by water infiltrating the hydrosystem. The instruments monitor the tilt as well as its spatial variation. Northward tilts reaching a 1 μrad amplitude are observed consecutively to rainfalls. The tilt amplitude is highly correlated with the Fontaine de Vaucluse outlet flow fluctuations. The measured tilt signal is also relatively homogeneous over a 150 m length. Different types of structure likely to produce such observations are tested in order to identify their location with respect to the tiltmeters, their dimension as well as the amount of water level variation in the structure. Following rainfalls, the infiltration of water modifies the pore pressure, inducing a medium deformation. The hypothesis of an homogeneous surface loading on the Vaucluse plateau is first refuted since the related tilt is much lower than the one measured. The water supplied by rainfalls has to accumulate in discontinuities in order to generate a higher tilt. So, the deformation related to a pressure exerted on a fracture filled by water is assessed. A first study reveals the interest of the tilt homogeneity information that constrains strongly the fracture properties. Thus, the fracture must be located at a distance more than a few hundreds metres from the tiltmeters in order to produce a tilt homogeneous in space. If the fracture is initially dry, it must also be filled on a height higher than 150 m consecutive to a rainfall in order to generate a tilt amplitude in the same magnitude as the one measured. Then, we explore the influence of water level variations on the tilt produced by a fracture located at the interface between the saturated and unsaturated zones, which are thereby permanently flooded. Since several parameters of that model satisfactorily explain the field observations, we discuss how simultaneous geodetical observations could provide complementary information that would further constrain the geometry of the structure at the origin of the medium deformation.
ISSN: 0956-540X

insu-01408482
https://hal-insu.archives-ouvertes.fr/insu-01408482
https://hal-insu.archives-ouvertes.fr/insu-01408482/document
https://hal-insu.archives-ouvertes.fr/insu-01408482/file/Lesparre-2017.pdf
DOI : 10.1093/gji/ggw446

Éditeur(s) : HAL CCSD Oxford University Press
Résumé : International audience
ISSN: 1369-3786

hal-01118199
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118199
DOI : 10.3109/13693786.2010.511287
PUBMED : 21067335

Éditeur(s) : HAL CCSD Oxford University Press
Résumé : International audience
We report on a fatal invasive infection due to the ascomycetous fungus Neocosmospora vasinfecta, in a 20-year-old European patient suffering from an acute lymphoblastic leukemia. The infection could not be controlled by a bitherapy combining liposomal amphotericin B and voriconazole. This is the second case of disseminated infection reported with this unusual fungus, which develops under its teleomorphic state, is fully resistant to all systemic antifungals, and which is known to live in tropical countries.
ISSN: 1369-3786

hal-01101419
https://hal.archives-ouvertes.fr/hal-01101419
PUBMED : 24432214

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
Iran is an active continental domain accommodating the convergence between the Arabia and Eurasia plates. In northwestern Iran, deformation between the Central Iranian block and the Caucasus domain is mainly accommodated by right lateral strike-slip on the Tabriz fault. Cities and villages, including the city of Tabriz, have been destroyed by several strong historical earthquakes (M similar to 7). In this study, we compare the slip-rates estimated from geodetic measurements (radar interferometry and UPS) with those determined by dating a geomorphological offset of an alluvial fan along the Tabriz fault. The GPS measurements along two profiles normal to the Tabriz fault suggest a slip-rate of 7.3 +/- 1.3 mm yr(-1). The persistent scatterer radar interferometry analysis of Envisat satellite archives from 2003 to 2010 shows a velocity gradient (6 +/- 3 mm yr(-1)) across the Tabriz fault in agreement with GPS results. Moreover, it reveals that most of the area located south of the Tabriz fault is affected by subsidence, and that some sections of the fault probably act as barriers to fluid migration which may have an impact on its mechanical behaviour. West of Tabriz morphotectonic investigations on an alluvial fan surface show a right-lateral cumulative offset of 320 +/- 40 m Luminescence analyses of the coarse matrix alluvial fan deposits provide an age of 46 +/- 3 ka. This yields a slip-rate comprised between 6.5 and 7.3 mm yr(-1) along this segment. These results suggest that the Late Quaternary slip-rate is in agreement with the present-day slip-rate estimated by geodetic measurements, showing no slip-rate changes during the past 45 000 yr. Short-term variations within the 45 000 yr related to temporal earthquake clustering over few seismic cycles cannot be ruled out, but if they exist, they do not affect the geodetic and the geomorphological estimates. This study is in agreement with previous ones suggesting that long-term slip-rates (i.e. averaged over several tens of seismic cycles) are consistent with geodetic estimated slip-rates (i.e. extrapolated from few years of interseismic observations), and suggests that perturbations of fault slip-rates are related to variations over few seismic cycles.
ISSN: 0956-540X

hal-00844695
https://hal.archives-ouvertes.fr/hal-00844695
https://hal.archives-ouvertes.fr/hal-00844695v2/document
https://hal.archives-ouvertes.fr/hal-00844695/file/rizza2013.pdf
DOI : 10.1093/gji/ggt041

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé :  
The maintenance in the long run of a positive carbon balance under very low irradiance is a prerequisite for survival of tree seedlings below the canopy or in small gaps in a tropical rainforest. To provide a quantitative basis for this assumption, experiments were carried out to determine whether construction cost (CC) and payback time for leaves and support structures, as well as leaf life span (i) differ among species and (ii) display an irradiance-elicited plasticity. Experiments were also conducted to determine whether leaf life span correlates to CC and payback time and is close to the optimal longevity derived from an optimization model. Saplings from 13 tropical tree species were grown under three levels of irradiance. Specific-CC was computed, as well as CC scaled to leaf area at the metamer level. Photosynthesis was recorded over the leaf life span. Payback time was derived from CC and a simple photosynthesis model. Specific-CC displayed only little interspecific variability and irradiance-elicited plasticity, in contrast to CC scaled to leaf area. Leaf life span ranged from 4 months to >26 months among species, and was longest in seedlings grown under lowest irradiance. It was always much longer than payback time, even under the lowest irradiance. Leaves were shed when their photosynthesis had reached very low values, in contrast to what was predicted by an optimality model. The species ranking for the different traits was stable across irradiance treatments. The two pioneer species always displayed the smallest CC, leaf life span, and payback time. All species displayed a similar large irradiance-elicited plasticity.
ISSN: 0022-0957

hal-01032198
https://hal.archives-ouvertes.fr/hal-01032198
DOI : 10.1093/jxb/err092

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
The diffusion of titanium along with Ni, Co and Mn in pure synthetic forsterite has been studied as a function of temperature, oxygen fugacity, crystallographic orientation and chemical potentials in the four-component system MgO–SiO2–TiO2–TiO1·5. In over 100 different experimental conditions, no Ti diffusion profiles with the classical shape of the error function were observed. Instead, the profiles vary between ‘stepped’ at high fO2 (probably owing to diffusion on octahedral sites and trapping in tetrahedral sites), to hockey-stick shapes at low fO2 owing to concentration-dependent diffusion. The profile shapes vary systematically between these end-members according to oxygen fugacity. These profile shapes are also reproduced in experiments using natural San Carlos olivine. The change in profile shape is interpreted to be a function of valence-state change from Ti4+ to Ti3+, shown by a sigmoidal log fO2–diffusivity relationship. To distinguish between Ti4+ and Ti3+ in forsterite, a diffusion profile was also investigated using ‘hydroxylation spectroscopy’ whereby a crystal from a diffusion experiment was hydroxylated by annealing in an H2O-rich fluid at moderate pressure and temperature. The point defects associated with the added structural OH were then determined by infrared spectroscopy, providing evidence for the presence of Ti4+ and Ti3+ at intermediate oxygen fugacity. The transition from Ti4+ to Ti3+ occurs at considerably higher fO2 in these diffusion experiments than in equilibrium experiments in similar systems. Titanium diffusion, qualified using a mobility parameter (M), is fastest along the c-axis, at high activity of silica, low oxygen fugacity and high temperature. The rate of Ti diffusion is broadly similar to those of Mn, Ni and Co, and closer to published rates of Mg self-diffusion in olivine than Si self-diffusion. The observed Ti3+ and Ti4+ diffusion occurs on the M-sites. From statistical examination of the large Mn, Ni and Co diffusivity dataset, we determine that there is a 102/3 dependence of diffusion on aSiO2; the cations diffuse more rapidly at high aSiO2. In addition, diffusivity has a 10–1/8 dependence on fO2, suggested to be the result of increased concentration of loosely bound Ti3+–vacancy pairs, which enhance the mobility of other cations. This behaviour is likely to be present in natural systems where trivalent (e.g. Fe3+, Al3+, Cr3+) and divalent cations diffuse together. Consideration should be given to diffusive interference by highly charged, fast-moving cations when extracting time scales from frozen diffusion profiles.
ISSN: 0022-3530

hal-01531344
https://hal.archives-ouvertes.fr/hal-01531344
DOI : 10.1093/petrology/egw067

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
OBJECTIVES: To better select for patients who most likely will benefit from cardiac surgery among those with infective endocarditis (IE), we aimed to identify preoperative markers associated with poor outcome after cardiac surgery for IE, and to evaluate the accuracy of European System for Cardiac Operative Risk Evaluation (EuroSCORE) II to predict mortality. METHODS: We enrolled all adult patients who underwent cardiac surgery during the acute phase of definite IE (Duke Criteria) in two referral centres for cardiac surgery. Patients were identified through intensive care unit (ICU) electronic databases, and data were collected from medical charts on standardized questionnaire. RESULTS: Between 2002 and 2013, 149 patients (117 males), with a median age of 64 years [interquartile range 52-73], fulfilled the inclusion criteria. Main complications before surgery were left ventricular dysfunction (23%), central nervous system symptomatic events (34%) and septic shock (24%). Most patients (95%) presented with valve regurgitation, and 49% had perivalvular abscess. Surgery was performed with a median delay of 12 days [5-24] after IE diagnosis, and mean EuroSCORE II was 15.8 (13.4-18.1). In-hospital mortality was 21%. Preoperative variables associated with mortality in multivariate analysis were obesity [odds ratio (OR) 3.67 [1.10-12.19], P = 0.03], vegetation extgreater15 mm (OR 6.72 [1.46-30.98], P = 0.01), septic shock (OR 4.87 [1.67-14.28], P = 0.004) and mechanical prosthetic valve IE (OR 4.99 [1.72-28.57], P = 0.007). EuroSCORE II underestimated mortality in patients with predicted mortality over 10%. CONCLUSION: Factors independently predictive of mortality after cardiac surgery for IE are obesity, septic shock, large vegetation and a mechanical prosthetic valve IE. EuroSCORE II underestimates post-cardiac surgery mortality in patients with IE
ISSN: 1010-7940

hal-01169802
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01169802
DOI : 10.1093/ejcts/ezv223
PUBMED : 26116921