North America -- Haiti -- Department du Ouest -- Port-au-Prince
Caribbean area
Latin America

Éditeur(s) : HAL CCSD Landes Bioscience
Résumé : International audience
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
Autophagy

hal-00735751
https://hal.archives-ouvertes.fr/hal-00735751
PUBMED : 22966490

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Evidence of a changing environment in the catchment area of a small pond (Lansquenet, Lorraine, France) during the last millennium was provided by coupling palynology data and organic ratios [terrestrial to aquatic ratio: TAR(HC); the C29 vs. C27 sterols, C29/C27(ST); average chain length, ACL and aquatic/macrophytes ratio, Paq]. The depositional and alteration conditions of organic matter (OM) were provided by the 5α(H)-stanols/Δ5-sterols ratio. This study shows that quite simple organic ratios clearly allow identification of the different evolution steps of a watershed, from a swamp to the progressive settlement of a pond. During the swampy period, the C/N(at) (ca. 11.1), TAR(HC) (ca. 36.8), C29/C27(ST) (ca. 8.7) and Paq (<0.3) show a high contribution of allochthonous OM associated with the presence of particular aquatic and mesohygrophilous species. A woody level dated to the XIIIth century reflects the period of the settlement of the pond in a more oxic environment [5α(H)-stanol/Δ5sterol ratio <0.2]. Then, the progressive increase in aquatic input and the development of submerged and floating macrophytes are evidenced by low C/N(at) (<7.6), TAR(HC) (ca. 2.7), C29/C27(ST) (ca. 2) and high Paq (ca. 0.5), suggesting an increase in the water level and eutrophication of the pond. A second oxic event [5α(H)-stanols/Δ5sterols ratio averaging 0.16], associated with extensive OM degradation, corresponds to the most recent dredging in 2002 and reflects an important disturbance of sediments due to pond management.
ISSN: 0146-6380

hal-00758066
https://hal.archives-ouvertes.fr/hal-00758066
DOI : 10.1016/j.orggeochem.2012.06.004

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Archives of Cardiovascular Diseases Supplements
Strasbourg, France

hal-01118035
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118035
DOI : 10.1016/S1878-6480(14)71283-2

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
Pituitary adenomas are currently classified by histological, immunocytochemical and numerous ultrastructural characteristics lacking unequivocal prognostic correlations. We investigated the prognostic value of a new clinicopathological classification with grades based on invasion and proliferation. This retrospective multicentric case-control study comprised 410 patients who had surgery for a pituitary tumour with long-term follow-up. Using pituitary magnetic resonance imaging for diagnosis of cavernous or sphenoid sinus invasion, immunocytochemistry, markers of the cell cycle (Ki-67, mitoses) and p53, tumours were classified according to size (micro, macro and giant), type (PRL, GH, FSH/LH, ACTH and TSH) and grade (grade 1a: non-invasive, 1b: non-invasive and proliferative, 2a: invasive, 2b: invasive and proliferative, and 3: metastatic). The association between patient status at 8-year follow-up and age, sex, and classification was evaluated by two multivariate analyses assessing disease- or recurrence/progression-free status. At 8 years after surgery, 195 patients were disease-free (controls) and 215 patients were not (cases). In 125 of the cases the tumours had recurred or progressed. Analyses of disease-free and recurrence/progression-free status revealed the significant prognostic value (p < 0.001; p < 0.05) of age, tumour type, and grade across all tumour types and for each tumour type. Invasive and proliferative tumours (grade 2b) had a poor prognosis with an increased probability of tumour persistence or progression of 25- or 12-fold, respectively, as compared to non-invasive tumours (grade 1a). This new, easy to use clinicopathological classification of pituitary endocrine tumours has demonstrated its prognostic worth by strongly predicting the probability of post-operative complete remission or tumour progression and so could help clinicians choose the best post-operative therapy.
ISSN: 0001-6322

hal-00875723
https://hal.archives-ouvertes.fr/hal-00875723
DOI : 10.1007/s00401-013-1084-y
PUBMED : 23400299

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Structural controls are critical during magmatic-to-hydrothermal transition in the formation of intrusion-related gold deposits. They may explain why only some parts of intrusions are mineralized and why only very few intrusions host large deposits. Moreover, most of these gold deposits postdate peak regional metamorphism and were formed in zones of relatively low strain. Indeed, the efficiency of structural gold traps is highest along favourably oriented intrusion/host-rock contacts where mechanical instability maintains high permeability in the cracked thermal aureole. This may be reinforced by melt injections from an underlying root zone. We present a structural analysis of the deformation features of a granite-pluton roof; large-scale dykes and a network of gold veins are intensively developed in this roof, recording a succession of mechanical instabilities. Our gravity survey underlines the presence of a pluton feeder zone located just beneath the mineralized network. It is argued that interferences between regional stress and melt injection in the feeder zone favoured the development of the network by strain located close to the granite roof. This stresses the role of mechanical instabilities triggered by the combined effects of regional stress and melt dynamics in determining the location and size of this type of gold deposit.
ISSN: 0191-8141

insu-00914780
https://hal-insu.archives-ouvertes.fr/insu-00914780
https://hal-insu.archives-ouvertes.fr/insu-00914780/document
https://hal-insu.archives-ouvertes.fr/insu-00914780/file/manuscript.pdf
DOI : 10.1016/j.jsg.2013.11.006

Éditeur(s) : Texas A & M University, Ocean Drilling Program, College Station, TX, United States (USA)
Résumé : This chapter presents major oxide and trace element determinations of igneous whole-rock compositions from sites drilled during Leg 60 and electron microprobe mineral and glass analyses of samples from Sites 454 and 458. Interarc basin basalts from the Mariana Trough (Sites 454 and 456) are similar in all respects to depleted mid-ocean ridge basalts. Basaltic andesites and andesites from Site 458 (Mariana fore-arc region) are more depleted than mid-ocean ridge basalts and show different geochemical behavior for Zr-, Hf, and Ti when compared on an extended Coryell- Masuda plot. [NOT CONTROLLED OCR]
Initial Reports of the Deep Sea Drilling Project (Texas A & M University, Ocean Drilling Program, College Station, TX, United States (USA)), 1981 , Vol. 60 , P. 657-677

Droits : Texas A & M University, Ocean Drilling Program, College Station, TX, United States (USA)
http://archimer.ifremer.fr/doc/1981/publication-5308.pdf
http://archimer.ifremer.fr/doc/00000/5308/

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The N-S oriented Raghane shear zone (8 degrees 30') delineates the western boundary of the Saharan metacraton and is, with the 4 degrees 50' shear zone, the most important shear zone in the Tuareg shield. It can be followed on 1000 km in the basement from southern Air, Niger to NE Hoggar, Algeria. Large subhorizontal movements have occurred during the Pan-African orogeny and several groups of granitoids intruded during the Neoproterozoic. We report U-Pb zircon datings (laser ICP-MS) showing that three magmatic suites of granitoids emplaced close to the Raghane shear zone at c. 790 Ma, c. 590 and c. 550 Ma. A comprehensive and detailed (158 sites, more than 1000 cores) magnetic fabric study was performed on 8 plutons belonging to the three magmatic suites and distributed on 200 km along the Raghane shear zone. The main minerals in all the target plutons do not show visible preferential magmatic orientation except in narrow shear zones. The AMS study shows that all plutons have a magnetic lineation and foliation compatible with the deformed zones that are zones deformed lately in post-solidus conditions. These structures are related to the nearby mega-shear zones, the Raghane shear zone for most of them. The old c. 793 Ma Touffok granite preserved locally its original structures. The magnetic structures of the c. 593 Ma Ohergehem pluton, intruded in the Aouzegueur terrane, are related to thrust structures generated by the Raghane shear zone while it is not the case of the contemporaneous plutons in the Assode-Issalane terrane whose structures are only related to the subvertical shear zones. Finally, the c. 550 Ma granite group has magnetic structure related to the N-S oriented Raghane shear zone and its associated NNE-SSW structures when close to them, but NW-SE oriented when further. These NW-SE oriented structures appear to be characteristic of the late Neoproterozoic evolution of the Saharan metacraton and are in relation to the convergence with the Murzuq craton. This evolution reflects the rheological contrast existing along the Raghane shear zone marking the western boundary of the Saharan metacraton.
ISSN: 0040-1951

hal-00429354
https://hal.archives-ouvertes.fr/hal-00429354
DOI : 10.1016/j.tecto.2009.04.022

Éditeur(s) : HAL CCSD American Association for the Advancement of Science
Résumé : The biodiversity-productivity relationship (BPR) is foundational to our understanding of the global extinction crisis and its impacts on ecosystem functioning. Understanding BPR is critical for the accurate valuation and effective conservation of biodiversity. Using ground-sourced data from 777,126 permanent plots, spanning 44 countries and most terrestrial biomes, we reveal a globally consistent positive concave-down BPR, showing that continued biodiversity loss would result in an accelerating decline in forest productivity worldwide. The value of biodiversity in maintaining commercial forest productivity alone-US$166 billion to 490 billion per year according to our estimation-is more than twice what it would cost to implement effective global conservation. This highlights the need for a worldwide reassessment of biodiversity values, forest management strategies, and conservation priorities.
ISSN: 0036-8075

hal-01607784
https://hal.archives-ouvertes.fr/hal-01607784
DOI : 10.1126/science.aaf8957
PRODINRA : 389856

Éditeur(s) : Blackwell science
Résumé : Patterns of mitochondrial DNA (mtDNA) variation were used to analyse the population genetic structure of southwestern Indian Ocean green turtle (Chelonia mydas) populations. Analysis of sequence variation over 396 bp of the mtDNA control region revealed seven haplotypes among 288 individuals from 10 nesting sites in the Southwest Indian Ocean. This is the first time that Atlantic Ocean haplotypes have been recorded among any Indo-Pacific nesting populations. Previous studies indicated that the Cape of Good Hope was a major biogeographical barrier between the Atlantic and Indian Oceans because evidence for gene flow in the last 1.5 million years has yet to emerge. This study, by sampling localities adjacent to this barrier, demonstrates that recent gene flow has occurred from the Atlantic Ocean into the Indian Ocean via the Cape of Good Hope. We also found compelling genetic evidence that green turtles nesting at the rookeries of the South Mozambique Channel (SMC) and those nesting in the North Mozambique Channel (NMC) belong to separate genetic stocks. Furthermore, the SMC could be subdivided in two different genetic stocks, one in Europa and the other one in Juan de Nova. We suggest that this particular genetic pattern along the Mozambique Channel is attributable to a recent colonization from the Atlantic Ocean and is maintained by oceanic conditions in the northern and southern Mozambique Channel that influence early stages in the green turtle life cycle.
Molecular Ecology (0962-1083) (Blackwell science), 2007 , Vol. 16 , N. 1 , P. 175-186

Droits : 2007 Blackwell
http://archimer.ifremer.fr/doc/2007/publication-2185.pdf
DOI:10.1111/j.1365-294X.2006.03122.x
http://archimer.ifremer.fr/doc/00000/2185/

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Past studies have shown that high coastal uplift rates are restricted to active areas, especially in a subduction context. The origin of coastal uplift in subduction zones, however, has not yet been globally investigated. Quaternary shorelines correlated to the last interglacial maximum (MIS 5e) were defined as a global tectonic benchmark (Pedoja et al. (2011)). In order to investigate the relationships between the vertical motion and the subduction dynamic parameters, we cross-linked this coastal uplift database with the "geodynamical" databases from Heuret (2005), Conrad and Husson (2009) and Müller et al. (2008). Our statistical study shows that: [1] the most intuitive parameters one can think responsible for coastal uplift (e.g., subduction obliquity, trench motion, oceanic crust age, interplate friction and force, convergence variation, dynamic topography, overriding and subducted plate velocity) are not related with the uplift (and its magnitude); [2] the only intuitive parameter is the distance to the trench which shows in specific areas a decrease from the trench up to a distance of ~300 km; [3] the slab dip (especially the deep slab dip), the position along the trench and the overriding plate tectonic regime are correlated with the coastal uplift, probably reflecting transient changes in subduction parameters. Finally we conclude that the first order parameter explaining coastal uplift is small-scale heterogeneities of the subducting plate, as for instance subducting aseismic ridges. The influence of large-scale geodynamic setting of subduction zones is secondary.
ISSN: 0264-3707

hal-00968538
https://hal.archives-ouvertes.fr/hal-00968538
https://hal.archives-ouvertes.fr/hal-00968538/document
https://hal.archives-ouvertes.fr/hal-00968538/file/henryterraces_v2.pdf
DOI : 10.1016/j.jog.2014.04.001

Éditeur(s) : HAL CCSD European Centre for Disease Prevention and Control
Résumé : International audience
In 2002, the French Food Safety Agency drew attention to the lack of information on the prevalence of human cryptosporidiosis in the country. Two years later, the ANOFEL Cryptosporidium National Network (ACNN) was set up to provide public health authorities with data on the incidence and epidemiology of human cryptosporidiosis in France. Constituted on a voluntary basis, ACNN includes 38 hospital parasitology laboratories (mainly in university hospitals). Each laboratory is engaged to notify new cases of confirmed human cryptosporidiosis, store specimens (e.g. stools, duodenal aspirates or biopsies) and related clinical and epidemiological data, using data sheet forms. From January 2006 to December 2009, 407 cryptosporidiosis cases were notified in France and 364 specimens were collected. Of the notified cases, 74 were children under four years of age, accounting for 18.2%. HIV-infected and immunocompetent patients represented 38.6% (n=157) and 28% (n=114) of cases, respectively. A marked seasonal pattern was observed each year, with increased number of cases in mid to late summer and the beginning of autumn. Genotyping of 345 isolates from 310 patients identified C. parvumin 168 (54.2%) cases, C. hominis in 113 (36.4%) and other species in 29 (9.4%), including C. felis (n=15), C. meleagridis (n=4), C. canis (n=4), Cryptosporidium chipmunk genotype (n=1), Cryptosporidium rabbit genotype (n=1) and new Cryptosporidium genotypes (n=4). These data represent the first multisite report of laboratory-confirmed cases of cryptosporidiosis in France.
ISSN: 1560-7917

hal-00926813
https://hal-unilim.archives-ouvertes.fr/hal-00926813
PUBMED : 20739000

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
In the Arokam Tenere, the three studied massifs of granitoids are located around the N-S oriented Raghane mega-shear zone, which separates two of the main domains of the Tuareg shield, the Saharan metacraton and the Central Hoggar. The field observations, AMS analyses and U-Pb zircon dating were completed by a study of Landsat images because of the scarcity of outcrops in several parts of the studied area.;The image analysis allows to distinguish Arokam-East and Abdou granitoids in the eastern plutonic complex. It has also shown that the western plutonic complex corresponds to two different intrusions: the Yvonne granite and granodiorite. This is confirmed by the magnetic fabric that presents different characteristics in the different granitoids. U-Pb zircon dating and field observations show that the Arokam-West basement granite is much older (1915 Ma) than the Hanane granodiorite (582 Ma) in the central plutonic complex. Arokam-East and -West granites then belong to the Eburnean basement. The magnetic fabric of these granites is mainly associated with a post-magmatic deformation, probably of Pan-African age. Yvonne granodiorite is likely contemporaneous of the main displacement along the Raghane shear zone. The Yvonne granite (594 Ma) and Hanane granodiorite have a fabric similar to that previously obtained in most plutons of the Tiririne area. This fabric is related to the regional stress field, associated with the activity of the Raghane shear zone, during the late-magmatic phase in the plutons. On the contrary, the magnetic fabric of the Abdou pluton is still reflecting only the magma flow.
ISSN: 0899-5362

hal-00617478
https://hal.archives-ouvertes.fr/hal-00617478
DOI : 10.1016/j.jafrearsci.2011.02.007

Éditeur(s) : HAL CCSD Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists
Résumé : International audience
Schistosome infection is a major public health concern affecting millions of people living in tropical regions of Africa, Asia, and South America. Schistosomes cause mild clinical symptoms in most subjects, whereas a small proportion of individuals presents severe clinical disease (as periportal fibrosis (PPF)) that may lead to death. Severe PPF results from an abnormal deposition of extracellular matrix proteins in the periportal spaces due to a chronic inflammation triggered by eggs and schistosome Ags. Extracellular matrix protein production is regulated by a number of cytokines, including IFN-gamma. We have now screened putative polymorphic sites within this gene in a population living in an endemic area for Schistosoma mansoni. Two polymorphisms located in the third intron of the IFN-gamma gene are associated with PPF. The IFN-gamma +2109 A/G polymorphism is associated with a higher risk for developing PPF, whereas the IFN-gamma +3810 G/A polymorphism is associated with less PPF. The polymorphisms result in changes in nuclear protein interactions with the intronic regions of the gene, suggesting that they may modify IFN-gamma mRNA expression. These results are consistent with the results of previous studies. Indeed, PPF is controlled by a major locus located on chromosome 6q22-q23, closely linked to the gene encoding the alpha-chain of the IFN-gamma receptor, and low IFN-gamma producers have been shown to have an increased risk of severe PPF. Together, these observations support the view that IFN-gamma expression and subsequent signal transduction play a critical role in the control of PPF in human hepatic schistosome infection (S. mansoni).
ISSN: 0022-1767

Droits : http://creativecommons.org/licenses/by-nc-nd/
hal-01211760
https://hal.archives-ouvertes.fr/hal-01211760
https://hal.archives-ouvertes.fr/hal-01211760/document
https://hal.archives-ouvertes.fr/hal-01211760/file/J%20Immunol-2003-Chevillard-5596-601.pdf
DOI : 10.4049/jimmunol.171.10.5596

Éditeur(s) : HAL CCSD
Résumé : International audience
Up-to-date estimates of the health outcomes of preterm children are needed for assessing perinatal care, informing parents, making decisions about care, and providing evidence for clinical guidelines. To determine survival and neonatal morbidity of infants born from 22 through 34 completed weeks' gestation in France in 2011 and compare these outcomes with a comparable cohort in 1997. The EPIPAGE-2 study is a national, prospective, population-based cohort study conducted in all maternity and neonatal units in France in 2011. A total of 2205 births (stillbirths and live births) and terminations of pregnancy at 22 through 26 weeks' gestation, 3257 at 27 through 31 weeks, and 1234 at 32 through 34 weeks were studied. Cohort data were collected from January 1 through December 31, 1997, and from March 28 through December 31, 2011. Analyses for 1997 were run for the entire year and then separately for April to December; the rates for survival and morbidities did not differ. Data are therefore presented for the whole year in 1997 and the 8-month and 6-month periods in 2011. Survival to discharge and survival without any of the following adverse outcomes: grade III or IV intraventricular hemorrhage, cystic periventricular leukomalacia, severe bronchopulmonary dysplasia, retinopathy of prematurity (stage 3 or higher), or necrotizing enterocolitis (stages 2-3). A total of 0.7% of infants born before 24 weeks' gestation survived to discharge: 31.2% of those born at 24 weeks, 59.1% at 25 weeks, and 75.3% at 26 weeks. Survival rates were 93.6% at 27 through 31 weeks and 98.9% at 32 through 34 weeks. Infants discharged home without severe neonatal morbidity represented 0% at 23 weeks, 11.6% at 24 weeks, 30.0% at 25 weeks, 47.5% at 26 weeks, 81.3% at 27 through 31 weeks, and 96.8% at 32 through 34 weeks. Compared with 1997, the proportion of infants surviving without severe morbidity in 2011 increased by 14.4% (P < .001) at 25 through 29 weeks and 6% (P < .001) at 30 through 31 weeks but did not change appreciably for those born at less than 25 weeks. The rates of antenatal corticosteroid use, induced preterm deliveries, cesarean deliveries, and surfactant use increased significantly in all gestational-age groups, except at 22 through 23 weeks. The substantial improvement in survival in France for newborns born at 25 through 31 weeks' gestation was accompanied by an important reduction in severe morbidity, but survival remained rare before 25 weeks. Although improvement in survival at extremely low gestational age may be possible, its effect on long-term outcomes requires further studies. The long-term results of the EPIPAGE-2 study will be informative in this regard.
ISSN: 2168-6211

hal-01258705
http://hal.univ-brest.fr/hal-01258705
PUBMED : 25621457
DOI : 10.1001/jamapediatrics.2014.3351

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Intraplate deformation is most often linked to major stress applied on plate margins. When such intraplate events are accompanied by magmatism, the use of several dating methods integrated within a multidisciplinary approach can bring constraints on the age, nature and source mobilized for generating the magma and in turn on the nature of the intraplate deformation. This study focuses on the large gabbro Arrikine sill (35 km in extension) emplaced within the Silurian sediments of the western margin of the Murzuq cratonic basin in southeastern Algeria. Its emplacement is dated during the early Devonian (415-400 Ma) through the determination of a reliable paleomagnetic pole by comparison with the Gondwana Apparent Polar Wander Path (APWP). This age can be correlated with deep phreatic eruptions before Pragian time thought to be at the origin of sand injections and associated circular structures in Algeria and Libya. For the sill, the K–Ar age of 325.6 ± 7.7 Ma is related to a K-rich aplitic phase that has K-enriched by more than 20% the Devonian gabbro. Laser-ICP-MS U–Pb method dates only inherited zircons mostly at c. 2030 Ma with additional ages at c. 2700 Ma and younger ones in the 766-598 Ma age range. The Arrikine sill is a high-Ti alkaline gabbro having the geochemical composition of a hawaiite akin to several intraplate continental and oceanic provinces, including the contemporaneous Aïr ring complexes province in Niger, but also to the Mauna Loa volcano in Hawaii. This peculiar composition akin to that of the contemporaneous Aïr province is in agreement with a lower Devonian age for the Arrikine sill.The lower Devonian Arrikine sill emplacement is related to a “Caledonian” transtensive reactivation of the western metacratonic boundary of the Murzuq craton. This event also generated in the Saharan platform the so-called “Caledonian unconformity” of regional extension, the Aïr ring complexes and magmatic rocks that produced sand injections. It could be related to rifting of the Hun terranes that occurred at the plate margin to the north (Stampfli and Borel, 2002, Blackey, 2008 and references therein). The mid-Carboniferous (c. 326 Ma) reactivation corresponds to Variscan compression on NW Africa generating aplitic fluids, but also to the major “Hercynian unconformity” of regional extension. The generation of the Arrikine magma is attributed to partial melting through adiabatic pressure release of uprising asthenosphere along tectonically reactivated mega-shear zones, here bordering the relictual Murzuq craton enclosed in the Saharan metacraton.
ISSN: 0899-5362

hal-01306637
https://hal.archives-ouvertes.fr/hal-01306637
DOI : 10.1016/j.jafrearsci.2015.11.019

Éditeur(s) : HAL CCSD
Résumé : International audience
In vitro susceptibility of 933 Candida isolates, from 16 French hospitals, to micafungin was determined using the Etest in each center. All isolates were then sent to a single center for determination of MICs by the EUCAST reference method. Overall essential agreement between the two tests was 98.5% at ±2 log2 dilutions and 90.2% at ±1 log2 dilutions. Categorical agreement was 98.2%. The Etest is a valuable alternative to EUCAST for the routine determination of micafungin MICs in medical mycology laboratories. Copyright © 2016, American Society for Microbiology. All Rights Reserved.
Antimicrobial Agents and Chemotherapy

hal-01367142
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01367142
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01367142/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01367142/file/Multicenter%20comparison%20of%20the%20Etest.pdf
DOI : 10.1128/AAC.00630-16

Éditeur(s) : HAL CCSD Wiley Open Access
Résumé : International audience
Estetrol (E4) is a natural estrogen with a long half-life produced only by the human fetal liver during pregnancy. The crystal structures of the estrogen receptor α (ERα) ligand-binding domain bound to 17β-estradiol (E2) and E4 are very similar, as well as their capacity to activate the two activation functions AF-1 and AF-2 and to recruit the coactivator SRC3. In vivo administration of high doses of E4 stimulated uterine gene expression, epithelial proliferation, and prevented atheroma, three recognized nuclear ERα actions. However, E4 failed to promote endothelial NO synthase activation and acceleration of endothelial healing, two processes clearly dependent on membrane-initiated steroid signaling (MISS). Furthermore, E4 antagonized E2 MISS-dependent effects in endothelium but also in MCF-7 breast cancer cell line. This profile of ERα activation by E4, uncoupling nuclear and membrane activation, characterizes E4 as a selective ER modulator which could have medical applications that should now be considered further.
ISSN: 1757-4676

hal-01118028
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118028
PUBMED : 25214462
PUBMEDCENTRAL : PMC4287935
DOI : 10.15252/emmm.201404112