Éditeur(s) : University of Florida University of Florida ( Gainesville, Fla. )
Résumé : (Thesis) Thesis (Ph. D.)--University of Florida, 1984.
(Bibliography) Bibliography: leaves 134-145.
Typescript.
Vita.
English and Spanish.
(Statement of Responsibility) by Sharleen Hirschi Simpson.
Costa Rica -- San José
Costa Rica
San Jose
Costa Rica
San Jose
UF

Droits : Copyright [name of dissertation author]. Permission granted to the University of Florida to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
000476231
11750803
ACP2485

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
ISSN: 0003-4975

hal-01563338
http://hal.univ-brest.fr/hal-01563338
DOI : 10.1016/j.athoracsur.2016.03.093
PUBMED : 27262916

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : National audience
Objectif Analyser les caractéristiques virologiques et les complications des syndromes grippaux chez les diabétiques en période hivernale. Patients et Méthodes Étude conduite dans 6 hôpitaux (Montpellier, Lyon, Cochin, Bichat, Limoges, Rennes) au cours de 3 saisons grippales (2012-2013, 2013-2014 et 2014-2015), sur 1 451 adultes hospitalisés avec syndrome grippal récent (début ≤ 7 jours), associant un signe respiratoire (toux, dys-pnée) et un signe systémique (fièvre, céphalées, malaise, myalgies). Les virus respiratoires étaient recherchés par RT-PCR sur prélèvement naso-pharyngé ou LBA (Centre National de Référence, Lyon). La vaccination anti-grippale, la présence d'un diabète, les comorbidités, les complications en cours d'hospitalisation (insuffisance rénale, cardiaque, respiratoire, pneumonie, décès) et la durée moyenne de séjour (DMS) étaient enregistrées. Les facteurs de risque de complications ont été étudiés par régression logistique multivariée ajustée sur âge, sexe, infection grippale, vaccination, diabète et antécédents de pathologies rénale, cardiaque ou respiratoire. Résultats Les hospitalisations ont eu lieu dans des services de maladies respiratoires, médecine interne, MIT et réanimation. Un diabète était présent chez 368 sujets (non traités : 15 %, ADO : 41 %, insuline : 27 %, mixte : 17 %). Les diabétiques étaient plus âgés (71 ± 15 vs 65 ± 20 ans, P < 0,001) et présentaient plus souvent un antécédent de pathologie rénale (18 % vs 8 %, P < 0,00001) ou cardiaque (19 % vs 11 %, P < 0,001). Leur couverture vaccinale était meilleure (60 % vs 46 %). Les données virologiques étaient comparables : grippe 38,9 % (76,1 % type A) vs 39,2 % ; (74,1 % type A) ; autres virus respiratoires : 17,0 % vs 19,9 %. La DMS était un peu plus élevée chez les diabétiques (9,1 ± 9 vs 8,9 ± 11, P = 0,015), avec une tendance à un risque de décès plus élevé (6,25 % vs 3,97 %, P 0,07). En analyse multivariée, le diabète était un facteur de risque de complications à type d'insuffisance rénale (OR : 1,66, IC 95 % : 1,10-2,52) mais pas d'insuffisance cardiaque, respiratoire ou de décès. Les complications n'étaient pas modi-fiées par les résultats virologiques. Conclusions Le diabète est un facteur de risque de complications rénales chez les patients hospitalisés avec syndrome grippal
ISSN: 1262-3636

hal-01300779
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01300779
DOI : 10.1016/S1262-3636(16)30020-9

Éditeur(s) : Elsevier
Résumé : During the Fanindien 2006 cruise of R/V 'Beautemps-Beaupre', high resolution multibeam bathymetry, sub-bottom profiling and sediment coring was carried out along the East African margin, offshore Tanzania and Mozambique (Indian Ocean). The newly acquired data reveal the presence of a giant deep-sea valley (the Tanzania channel) that is more than 10 km wide at 4000 m water depth, along the continental rise. The valley remains similar to 70 m deep and 7 km wide at 800 km from the Tanzania coast. Morphological comparison with worldwide submarine channels show that the Tanzania channel is one of the largest known submarine valleys. This discovery brings new light on development of submarine valleys that drain sediments originated from the East African Rift System (EARS) highlands (i.e. the Tanzania channel and its neighbor Zambezi channel located similar to 1000 km southward). Both of the systems have a morphology markedly different to the classical sinuous, V-shaped channels located at similar latitudes (e.g. the Zaire or Amazon channels). Their submarine drainage system consists of a downslope converging tributary canyons joining a central trunk channel in the continental rise. The presence of such giant deep-sea drainage systems is probably linked to a strong structural control on the sediment pathway, associated to a massive sediment transfer towards the Indian Ocean in relation with the tectonic activity of the East African Rift System (i.e. the uplift periods trough mid-Miocene and Plio-Pleistocene times) and its interplay with the East African equatorial climate changes.
Marine Geology (0025-3227) (Elsevier), 2008-12 , Vol. 255 , N. 3-4 , P. 179-185

Droits : 2008 Elsevier B.V. All rights reserved.
http://archimer.ifremer.fr/doc/00324/43491/42958.pdf
DOI:10.1016/j.margeo.2008.09.002
http://archimer.ifremer.fr/doc/00324/43491/

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Aims: The aims of this study were to compare short-and long-term outcomes for clinical T2N0 oesophageal cancer with analysis of (i) primary surgery (S) versus neoadjuvant therapy plus surgery (NS), (ii) squamous cell carcinoma and adenocarcinoma subsets; and (iii) neoadjuvant chemoradiotherapy versus neoadjuvant chemotherapy.Methods: Data were collected from 30 European centres from 2000 to 2010. Among 2944 included patients, 355 patients (12.1%) had cT2N0 disease; 285 (S) and 70 (NS), were compared in terms of short-and long-term outcomes. Propensity score matching analyses were used to compensate for differences in baseline characteristics.Results: No significant differences between the groups were shown in terms of in hospital morbidity and mortality. Nodal disease was observed in 50% of S-group at the time of surgery, with 20% pN2/N3. Utilisation of neoadjuvant therapy was associated with significant tumour downstaging as reflected by increases in pT0, pN0 and pTNM stage 0 disease, this effect was further enhanced with neoadjuvant chemoradiotherapy. After adjustment on propensity score and confounding factors, for all patients and subset analysis of squamous cell and adenocarcinoma, neoadjuvant therapy had no significant effect upon survival or recurrence (overall, loco-regional, distant or mixed) compared to surgery alone. There were no significant differences between neoadjuvant chemotherapy and chemoradiotherapy in short-or long-term outcomes.Conclusion: The results of this study suggest that a surgery alone treatment approach should be recommended as the primary treatment approach for cT2N0 oesophageal cancer despite 50% of patients having nodal disease at the time of surgery.
ISSN: 0959-8049

hal-01666517
https://hal.univ-lorraine.fr/hal-01666517
DOI : 10.1016/j.ejca.2015.11.024

Éditeur(s) : Elsevier
Résumé : During the Fanindien 2006 cruise of R/V 'Beautemps-Beaupre', high resolution multibeam bathymetry, sub-bottom profiling and sediment coring was carried out along the East African margin, offshore Tanzania and Mozambique (Indian Ocean). The newly acquired data reveal the presence of a giant deep-sea valley (the Tanzania channel) that is more than 10 km wide at 4000 m water depth, along the continental rise. The valley remains similar to 70 m deep and 7 km wide at 800 km from the Tanzania coast. Morphological comparison with worldwide submarine channels show that the Tanzania channel is one of the largest known submarine valleys. This discovery brings new light on development of submarine valleys that drain sediments originated from the East African Rift System (EARS) highlands (i.e. the Tanzania channel and its neighbor Zambezi channel located similar to 1000 km southward). Both of the systems have a morphology markedly different to the classical sinuous, V-shaped channels located at similar latitudes (e.g. the Zaire or Amazon channels). Their submarine drainage system consists of a downslope converging tributary canyons joining a central trunk channel in the continental rise. The presence of such giant deep-sea drainage systems is probably linked to a strong structural control on the sediment pathway, associated to a massive sediment transfer towards the Indian Ocean in relation with the tectonic activity of the East African Rift System (i.e. the uplift periods trough mid-Miocene and Plio-Pleistocene times) and its interplay with the East African equatorial climate changes. (C) 2008 Elsevier B.V. All rights reserved.
Marine Geology (0025-3227) (Elsevier), 2008-12 , Vol. 255 , N. 3-4 , P. 179-185

Droits : 2008 Elsevier B.V. All rights reserved.
http://archimer.ifremer.fr/doc/2008/publication-6855.pdf
DOI:10.1016/j.margeo.2008.09.002

Éditeur(s) : HAL CCSD
Résumé : International audience
o abstract
Revue Des Maladies Respiratoires

hal-01647076
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01647076
DOI : 10.1016/j.rmr.2017.07.022
PUBMED : 28935495

Éditeur(s) : HAL CCSD Springer
Résumé : International audience
Diabetologia
Stockholm, Sweden

hal-01204766
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01204766
DOI : 10.1007/s00125-015-3687-4

Éditeur(s) : HAL CCSD European Respiratory Society
Résumé : International audience
Telomerase reverse transcriptase (TERT) or telomerase RNA (TERC) gene mutation is a major monogenic cause of pulmonary fibrosis. Sequencing of TERT/TERC genes is proposed to patients with familial pulmonary fibrosis. Little is known about the possible predictors of this mutation and its impact on prognosis. We retrospectively analysed all the genetic diagnoses made between 2007-2014 in patients with pulmonary fibrosis. We evaluated the prevalence of TERT/TERC disease-Associated variant (DAV), factors associated with a DAV, and the impact of the DAV on survival. 237 patients with pulmonary fibrosis (153 with familial pulmonary fibrosis, 84 with telomere syndrome features without familial pulmonary fibrosis) were tested for TERT/TERC DAV. DAV was diagnosed in 40 patients (16.8%), including five with non-idiopathic interstitial pneumonia. Prevalence of TERT/TERC DAV did not significantly differ between patients with familial pulmonary fibrosis or with only telomere syndrome features (18.2% versus 16.4%). Young age, red blood cell macrocytosis, and low platelet count were associated with the presence of DAV; the probability of DAV was increased for patients 40-60 years. Transplant-free survival was lower with than without TERT/TERC DAV (4.2 versus 7.2 years; p=0.046). TERT/TERC DAV were associated with specific clinical and biological features and reduced transplantfree survival. ©ERS 2016.
ISSN: 0903-1936

hal-01467555
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01467555
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01467555/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01467555/file/Prevalence%20and%20characteristics%20of%20TERT.pdf
DOI : 10.1183/13993003.02115-2015

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
ISSN: 0168-583X

hal-01685819
https://hal.univ-antilles.fr/hal-01685819
DOI : 10.1016/0168-583X(91)95281-H

Éditeur(s) : HAL CCSD
Résumé : International audience
GYNECOLOGIE OBSTETRIQUE FERTILITE & SENOLOGIE

hal-01653280
https://hal.archives-ouvertes.fr/hal-01653280
DOI : 10.1016/j.gofs.2016.12.017
PUBMED : 28238320

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
Background: HCV treatment uptake has drastically increased in HIV-HCV coinfected patients in France since direct-acting antiviral (DAA) treatment approval, resulting in HCV cure in 63% of all HIV-HCV patients by the end of 2015. We investigated the impact of scaling-up DAA on HCV prevalence in the whole HIV population and in various risk groups over the next 10 years in France using a transmission dynamic compartmental model.Methods: The model was based on epidemiological data from the French Dat’AIDS cohort. Eight risk groups wereconsidered, including high-risk (HR) and low-risk (LR) men who have sex with men (MSM) and male/female heterosexuals,intra-venous drug users, or patients from other risk groups. The model was calibrated on prevalence and incidence dataobserved in the cohort between 2012 and 2015.Results: On January 1, 2016, 156,811 patients were registered as infected with HIV in France (24,900 undiagnosedpatients) of whom 7938 (5.1%) had detectable HCV-RNA (722 undiagnosed patients). Assuming a treatmentcoverage (TC) rate of 30%/year (i.e., the observed rate in 2015), model projections showed that HCV prevalenceamong HIV patients is expected to drop to 0.81% in 2026. Sub-analyses showed a similar decrease of HIV-HCVprevalence in most risk groups, including LR MSM. Due to higher infection and reinfection rates, predicted prevalencein HR MSM remained stable from 6.96% in 2016 to 6.34% in 2026. Increasing annual TC rate in HR MSM to 50/70%would decrease HCV prevalence in this group to 2.35/1.25% in 2026. With a 30% TC rate, undiagnosed patients wouldaccount for 34% of HCV infections in 2026.Conclusions: Our model suggests that DAA could nearly eliminate coinfection in France within 10 years for most riskgroups, including LR MSM. Elimination in HR MSM will require increased TC.
ISSN: 1741-7015

Droits : info:eu-repo/semantics/OpenAccess
inserm-01685739
http://www.hal.inserm.fr/inserm-01685739
http://www.hal.inserm.fr/inserm-01685739/document
http://www.hal.inserm.fr/inserm-01685739/file/2017%2C%20Virlogeux%20-%20Modeling%20HIV-HCV%20coinfection.pdf
DOI : 10.1186/s12916-017-0979-1

Éditeur(s) : HAL CCSD
Résumé : Xth world conference SEA 2016, Rome, 13-15 juin 2016
https://hal-agroparistech.archives-ouvertes.fr/hal-01504655

hal-01504655
https://hal-agroparistech.archives-ouvertes.fr/hal-01504655

Éditeur(s) : HAL CCSD Nature Publishing Group
Résumé : International audience
In cyclic females, FSH stimulates ovarian estradiol (E2) production and follicular growth up to the terminal stage. A transient elevation in circulating FSH and E2 levels occurs shortly after birth. But what could be the action of FSH on the ovary during this period, and in particular how it stimulates ovarian steroidogenesis without supporting terminal follicular maturation is intriguing. By experimentally manipulating FSH levels, we demonstrate in mice that the mid-infantile elevation in FSH is mandatory for E2 production by the immature ovary, but that it does not stimulate follicle growth. Importantly, FSH increases aromatase expression to stimulate E2 synthesis, however it becomes unable to induce cyclin D2, a major driver of granulosa cell proliferation. Besides, although FSH prematurely induces luteinizing hormone (LH) receptor expression in granulosa cells, LH pathway is not functional in these cells to induce their terminal differentiation. In line with these results, supplying infantile mice with a superovulation regimen exacerbates E2 production, but it does not stimulate the growth of follicles and it does not induce ovulation. Overall, our findings unveil a regulation whereby high postnatal FSH concentrations ensure the supply of E2 required for programming adult reproductive function without inducing follicular maturation before puberty.
ISSN: 2045-2322

hal-01516023
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01516023
DOI : 10.1038/srep46222
PUBMED : 28397811
PUBMEDCENTRAL : PMC5387682

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
OBJECTIVE: The WEGENT trial and other short-term studies suggested that azathioprine or methotrexate could effectively maintain granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA) remission. Whether differences in relapse or adverse event rates would appear after discontinuation of those 2 maintenance regimens and longer follow-up remains unknown. METHODS: Long-term outcomes for the patients enrolled in the WEGENT trial were analyzed according to their randomization group. Parameters at trial entry were evaluated as potential prognostic factors for death, relapse or damage in multivariate models. RESULTS: Data were returned for 88.8% of the 126 original participants. Median [95% confidence interval] followup was 11.9 [11.3-12.5] years. For the azathioprine and methotrexate arms, respectively, the 10-year overall survival rates were 75.1% [64.8-86.9] and 79.9% [70.3-90.8] (P = 0.56), and relapse-free survival rates 26.3% [17.3-40.1] and 33.5% [23.5-47.7] (P = 0.29). No between-arm differences were observed for relapse, adverse events, damage, survival rates without severe side effects and survival rates without relapse and severe side effects. Considering only the 97 GPA patients, no between-arm survival differences were observed. Relapse-free survival was shorter for GPA than MPA patients but the multivariate analysis retained anti-PR3-ANCA-positivity, and not GPA, as being independently associated with relapse. CONCLUSION: This long-term analysis confirms that azathioprine and methotrexate are comparable options for maintaining GPA or MPA remission. Despite good overall survival, relapses, adverse events and damage remain matters of concern and further studies are needed to reduce them.
ISSN: 2326-5205

hal-01217989
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01217989
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01217989/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01217989/file/Long-term%20outcomes%20of%20the%20WEGENT%20trial_accepted.pdf
DOI : 10.1002/art.39450

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The Tso Morari serpentinites in the Ladakh area, northwest Himalaya, originated from the forearc mantle overlying the northward subducting Neo-Tethys lithosphere and the margin of the Indian continent. The serpentinites are characterized by high concentration of fluid-mobile elements (FME: As, Sb, B, Li, and U) compared to ophiolitic or abyssal serpentinites. The Pb isotopic compositions of serpentinites show influence of the subducted Indian continental lithosphere. Trace element concentrations of antigorite determined in situ with Laser Ablation High Resolution Inductively Coupled Mass Spectrometer (LA-HR-ICP-MS) show high contents of FME including Pb, in contrast to the spatially associated iron oxides. Rare earth elements (REE) and compatible elements, such as Sc and Co, remained immobile during the hydration, allowing the identification of the primary minerals (olivine or orthopyroxene) from which serpentine formed. Serpentinized olivine displays higher Sb and As concentrations (up to 1000 x PM) than serpentinized orthopyroxenes that are enriched in Pb, Cs and Li (2 to up to 10 x PM).;We propose that the observed FME distribution in two types of serpentine reflect the differential incorporation of FME during the downward movement of the serpentinite along the subduction plane. At temperature lower than 400 degrees C, at shallow depths, olivine is preferentially serpentinized and incorporates elements that are fluid soluble at low temperatures, such as Sb and As. Above 400 degrees C, orthopyroxene is hydrated and incorporates Pb, Cs, Li and possibly Ba. Boron and U are incorporated in both types of serpentine suggesting that they are released from slabs at temperatures around 300-400 degrees C. The serpentine acts as a sink for water, but also for FME and transports them to deeper and hotter levels in the mantle, down to the isotherm 600-650 degrees C where dehydration occurs.
ISSN: 0009-2541

hal-00475565
https://hal.archives-ouvertes.fr/hal-00475565
DOI : 10.1016/j.chemgeo.2009.10.002

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
ISSN: 0168-583X

hal-01685803
https://hal.univ-antilles.fr/hal-01685803
DOI : 10.1016/0168-583X(93)90750-Z

Éditeur(s) : HAL CCSD
Résumé : International audience
o abstract
Revue Des Maladies Respiratoires

hal-01647782
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01647782
DOI : 10.1016/j.rmr.2017.07.017
PUBMED : 28939155

Éditeur(s) : HAL CCSD Federation of American Society of Experimental Biology
Résumé : International audience
Testes of most male mammals present the particularity of being externalized from the body and are consequently slightly cooler than core body temperature (4-8 degrees C below). Although, hypothermia of the testis is known to increase germ cells apoptosis, little is known about the underlying molecular mechanisms, including cold sensors, transduction pathways, and apoptosis triggers. In this study, using a functional knockout mouse model of the cold and menthol receptors, dubbed transient receptor potential melastatine 8 (TRPM8) channels, we found that TRPM8 initiated the cold-shock response by differentially modulating cold- and heat-shock proteins. Besides, apoptosis of germ cells increased in proportion to the cooling level in control mice but was independent of temperature in knockout mice. We also observed that the rate of germ cell death correlated positively with the reactive oxygen species level and negatively with the expression of the detoxifying enzymes. This result suggests that the TRPM8 sensor is a key determinant of germ cell fate under hypothermic stimulation.Borowiec, A.-S., Sion, B., Chalmel, F., Rolland, A. D., Lemonnier, L., De Clerck, T., Bokhobza, A., Derouiche, S., Dewailly, E., Slomianny, C., Mauduit, C., Benahmed, M., Roudbaraki, M., Jegou, B., Prevarskaya, N., Bidaux, G. Cold/menthol TRPM8 receptors initiate the cold-shock response and protect germ cells from cold-shock-induced oxidation.
ISSN: 0892-6638

hal-01390973
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01390973
DOI : 10.1096/fj.201600257R
PUBMED : 27317670

Éditeur(s) : HAL CCSD AGU and the Geochemical Society
Résumé : International audience
Microbathymetry data, in situ observations, and sampling along the 13°20′N and 13°20′N oceanic core complexes (OCCs) reveal mechanisms of detachment fault denudation at the seafloor, links between tectonic extension and mass wasting, and expose the nature of corrugations, ubiquitous at OCCs. In the initial stages of detachment faulting and high-angle fault, scarps show extensive mass wasting that reduces their slope. Flexural rotation further lowers scarp slope, hinders mass wasting, resulting in morphologically complex chaotic terrain between the breakaway and the denuded corrugated surface. Extension and drag along the fault plane uplifts a wedge of hangingwall material (apron). The detachment surface emerges along a continuous moat that sheds rocks and covers it with unconsolidated rubble, while local slumping emplaces rubble ridges overlying corrugations. The detachment fault zone is a set of anostomosed slip planes, elongated in the along-extension direction. Slip planes bind fault rock bodies defining the corrugations observed in microbathymetry and sonar. Fault planes with extension-parallel stria are exposed along corrugation flanks, where the rubble cover is shed. Detachment fault rocks are primarily basalt fault breccia at 13°20′N OCC, and gabbro and peridotite at 13°30′N, demonstrating that brittle strain localization in shallow lithosphere form corrugations, regardless of lithologies in the detachment zone. Finally, faulting and volcanism dismember the 13°30′N OCC, with widespread present and past hydrothermal activity (Semenov fields), while the Irinovskoe hydrothermal field at the 13°20′N core complex suggests a magmatic source within the footwall. These results confirm the ubiquitous relationship between hydrothermal activity and oceanic detachment formation and evolution.
ISSN: 1525-2027

hal-01571973
https://hal.archives-ouvertes.fr/hal-01571973
https://hal.archives-ouvertes.fr/hal-01571973v2/document
https://hal.archives-ouvertes.fr/hal-01571973/file/Escart-n_et_al-2017-Geochemistry%2C_Geophysics%2C_Geosystems.pdf
DOI : 10.1002/2016GC006775