Éditeur(s) : EDP Sciences
Résumé : Lessons for the future from two development projects in aquaculture in the French overseas territories. Numerous research and development projects have been launched since the seventies in the French overseas territories. Their aim was to foster new activities in agriculture based on local productions for local markets, notably in the French West Indies (FWI). In this paper we analyze two development projects on the rearing of giant freshwater prawn, one in the FWI and the other in French Guyana, over twenty years after their launching. The purpose of these compared studies is twofold: first to try to understand why a set of relevant technical innovations ended in failure 15 years later; second to identify recommendations in terms of methodology in order to diminish risks of mistakes or failure for future projects. To reach this goal we followed two approaches. A first analysis is based on a set of three criteria: social acceptability, legitimacy and time planning. The second analysis, justified by the subjective need for an explanatory tool, is based on the actor-network theory. The results show that beyond the levels of political support and financial investment and support the three key criteria for success are: (i) reactivity of the decision-makers, notably when markets change, (ii) quality of leadership transfer between the launching phase and the stabilized phase, and (iii) capacity of the decision-makers to take into account the concrete consequences of the various scenarios. Regarding this third criterion, our analysis suggests that the scenario of full technical success needs to be explored, notably in terms of economic sustainability. The integration of these two types of analyses into an ex-ante frame should contribute to reducing risks of failure in similar development projects.
De nombreux projets d’aquaculture ont été menés depuis les années 1970 dans les territoires et départements français d’outre-mer. L’objectif était de diversifier l’agriculture avec des productions destinées au marché local comme aux Antilles, ou à l’exportation comme en Guyane. L’étude s’intéresse au bilan de deux projets d’élevage de la crevette tropicale d’eau douce aux Antilles et en Guyane, plus de vingt ans après leur lancement. L’objectif est de comprendre comment des innovations technologiques pertinentes ont conduit à deux échecs sur le moyen terme et de tirer des recommandations de méthode afin de réduire les risques d’erreurs ultérieures. Pour cela, deux cadres d’analyse sont mobilisés : le premier s’appuie sur les concepts de temporalité, légitimité et acceptabilité ; le second, motivé par la recherche subjective de cadres explicatifs, emprunte la vision de la théorie de l’acteur-réseau. Les trois déterminants majeurs du succès ou de l’échec se révèlent être la réactivité des responsables face aux problèmes d’adaptation à l’évolution des marchés, la qualité du transfert du leadership lors du passage de la phase de lancement à la phase de croisière et enfin la capacité de prendre en compte dès le départ les conséquences des scénarios d’évolution du projet, y compris la réussite technique. Une capacité d’intégration de ces types d’analyse, dans un cadre ex ante, devrait permettre de réduire les risques d’échec dans des projets de développement similaires à venir.
Natures Sciences et Sociétés (1240-1307) (EDP Sciences), 2013-12 , Vol. 21 , N. 4 , P. 400-415

Droits : NSS-Dialogues, EDP Sciences 2014
http://archimer.ifremer.fr/doc/00187/29784/28242.pdf
DOI:10.1051/nss/2014004
http://archimer.ifremer.fr/doc/00187/29784/

Résumé : Les pathologies inflammatoires démyélinisantes primitives du système nerveux central (SNC) sont dominées par deux entités : la sclérose en plaques (SEP) et la neuromyélite optique (NMO). Ces deux pathologies se différencient par : 1. leur phénotype, la NMO se caractérisant par une myélite extensive dans le plan transversal et longitudinal et peu de lésions encéphaliques initiales ; 2. leur sévérité, le pronostic de la NMO étant moins bon que celui de la SEP ; 3. leur mécanisme immunologique, puisque l’immunité humorale domine nettement dans la NMO, cette pathologie répondant peu ou pas aux traitementshabituellement prescrits dans la SEP. Un anticorps sérique (IgG-NMO) a été retrouvé chez les patients atteints de NMO avec une sensibilité de 50-70% et une spécificité de 90-100%. Cet anticorps a pour cible le principal canal hydrique du SNC, l’aquaporine-4 (AQP4), qui se situe principalement sur les pieds astrocytaires jalonnant la barrière hémato-encéphalique. La SEP est relativement familière des neurologues car décrite sur le plan épidémiologique et dans son histoire naturelle depuis plus d’un siècle à travers de larges séries réalisées parfois en population générale. Son approche thérapeutique progresse suite à des essais contrôlés qui s’accumulent depuis maintenant près de 20 ans. Toutefois, la majorité des travaux ont été effectués chez les populations Caucasiennes en raison de sa plus grande fréquence dans ces populations. A l’inverse, la NMO garde encore un relatif mystère à cause de sa relative rareté, l’établissement très récent de critères diagnostiques et une physiopathologie très récemment éclaircie par la découverte de l’IgG-NMO qui a indiscutablement suscité un regain d’intérêt de cette affection. Ainsi, son incidence est quasiment inconnue de même que sa susceptibilité génétique. La progression du handicap de la NMO qu’il soit visuel ou moteur à l’évidence sévère, ne repose toujours pas sur des chiffres précis, la description des lésions neuroradiologiques reste encore très embryonnaire. Enfin, même s’il existe un consensus pour traiter énergiquement les poussées de NMO et les espacer, il n’existe quasiment aucune étude prospective.
Introduction: Aim of the study is to describe épidemiology, phenotype and treatment of demyelinating inflammatory diseases of the central nervous system (CNS) namely multiple sclerosis (MS) and neuromyelitis optica (NMO) in French West Indies.Epidemiology: MS emerged in the French West Indian (FWI) population with an incidence of 1.27/100 000 (CI 95%: 1.16-1.38) for the period 1992-2007 while incidence of NMO remained stable at 0.19/100,000 (CI 95%: 0.15–0.23). Both migration in Metropolitean France (MF) and decrease of sun exposure were risk factors for MS acquisition in FWI. Phenotype and treatment of NMO: NMO is a very rapidly disabling disease with median times to reach DSS 3, 6 and 8 of one year, 8 years and 22 years respectively. However, treatment by plasma exchanges were shown to reduce sequellae of NMO attacks ; mitoxantrone and rituximab reduced significantly annualized relapse rate (ARR) from 1.7 to 0.29 (p<10-4) and from 1,34 to 0,56 (p=0.0005) respectively, improving dramatically natural course of NMO.Phenotype and treatment of MS: Absence of Migration in MF in MS patients was found to be the strongest independent predictive factor of disability progression to DSS 6 (hazard ratio, 2.59; p=0.0002); beside short time to DSS3 (p=0.005), later age at onset (p=0.005), and multi-symptomatic onset (p=0.03). Treatment of MS by interferon beta-1 had a moderate impact in MS while natalizimab proved to be highly effective by reducing drastically ARR and inflammatory parameters on magnetic resonance imaging. Conclusion: Spectrum of demyelinating inflammatory disorders of CNS has reversed in French West Indies with overrepresentation of MS. Agressive therapy is needed to improve prognosis of NMO. Rapidly increasing of its incidence makes MS a new public health problem in French West Indies.

http://www.theses.fr/2012AGUY0511/document

Résumé : Nos travaux ont permis d'étudier l'effet combiné de la maturation, du mûrissement et des périodes climatiques, sur le profil des composés bioactifs de la banane Musa Cavendish, issus des French West Indies (FWI). La teneur en polyphénols des bananes 400 Degrés Jour (dj) est restée inchangée, tandis que les bananes 600 et 900 dj ont présenté une augmentation significative de leurs teneurs en polyphénols pendant la maturation (pThe combined influence of maturation, ripening and climate periods on French West Indies (FWI) bananas, Musa Cavendish, bioactive compounds profile was studied. The polyphenol content of the 400 dd bananas remained unchanged, while the 600 and 900 dd bananas exhibited a significant polyphenol increase during ripening (p
http://www.theses.fr/2012AGUY0533

Éditeur(s) : HAL CCSD Maison de la géographie
Résumé : International audience
The paper points out the main divergences between the points of view of the inhabitants of Morne-Rouge (Martinique, French West Indies) and of volcanologists regarding the characteristics of a future eruption of Mount Pelée. The study is based on comparisons between the public’s perception of potentially threatened areas and scientific hazard maps.
El artículo trata de evidenciar las principales discrepancias entre el punto de vista de la población del Morne-Rouge (Martinica) y el de los vulcanólogos en cuanto a las características de una erupción venidera de la montagne Pelée. El estudio se funda, en particular, en una comparación entre la cartografía de la percepción de las zonas amenazadas y la cartografía de las zonas de amenazas volcánicas realizada por los científicos.
L’article met en évidence les principales divergences entre le point de vue des habitants du Morne-Rouge (Martinique) et celui des volcanologues à propos des caractéristiques d’une prochaine éruption de la montagne Pelée. Il s’appuie notamment sur une cartographie de la perception des espaces menacés, confrontée à l’évaluation scientifique des types et des zones d’aléa volcanique.
ISSN: 1769-7298

Droits : info:eu-repo/semantics/OpenAccess
hal-01161639
https://hal.archives-ouvertes.fr/hal-01161639
https://hal.archives-ouvertes.fr/hal-01161639/document
https://hal.archives-ouvertes.fr/hal-01161639/file/PELEE.pdf

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
Chlordecone (CLD) was an organochlorine insecticide whose previous use resulted in an extensive pollution of the environment with severe health effects and social consequences. A closely related compound, 5b-hydrochlordecone (5b-hydroCLD), has been searched for and often detected in environmental matrices from the geographical area where CLD was applied. The current consensus considered that its presence was not the result of a biotic or abiotic dechlorination of CLD in these matrices but rather the consequence of its presence as impurity (synthesis by-product) in the CLD released into the environment. The aim of the present study was to determine if and to what extent degradation of CLD into 5b-hydroCLD occurred in the field. To test this hypothesis, the ratios of 5b-hydroCLD and CLD concentrations in a dataset of 810 soils collected between 2006 and 2012 in Martinique were compared to the ratios measured in 3 samples of the CLD dust commercial formulations applied in the banana fields of French West Indies (FWI) and 1 sample of the technical-grade CLD corresponding to the active ingredient used in such formulations. Soil data were processed with a hierarchical Bayesian model to account for random measurement errors and data censoring. Any pathway of CLD transformation into 5b-hydroCLD occurring over the long term in FWI soils would indeed change the ratio of 5b-hydroCLD/CLD compared to what it was in the initially applied formulations. Results showed a significant increase of the 5b-hydroCLD/CLD ratio in the soils-25 times greater in soil than in commercial formulations-which suggested that natural CLD transformation into 5b-hydroCLD over the long term occurred in these soils. Results from this study may impact future decisions for the remediation of the polluted areas.
ISSN: 0944-1344

hal-01347150
https://hal.archives-ouvertes.fr/hal-01347150
https://hal.archives-ouvertes.fr/hal-01347150/document
https://hal.archives-ouvertes.fr/hal-01347150/file/Devault_15973.pdf
DOI : 10.1007/s11356-015-4865-0

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
Purpose Human papillomavirus (HPV) is known to play a role in the development of head and neck squamous cell carcinomas (HNSCC) and to date, no study has reported on the association between oral HPV infection and HNSCC in the Caribbean. The objective was to determine the prevalence of oral HPV infection in the French West Indies (FWI), overall and by HPV genotype, among HNSCC cases and healthy population controls. Method We used data from a population-based case-control study conducted in the FWI. The prevalence of oral HPV was estimated separately among 100 HNSCC cases (mean age 59 years) and 308 population controls (mean age 57 years). Odds ratios (OR) and 95% confidence intervals (CI) were estimated using a logistic regression adjusting for age, sex, tobacco, and alcohol consumption, to assess the association between oral HPV infection and HNSCC. Results Prevalence of oral HPV infections was 26% in controls (30% in men and 14% in women) and 36% in HNSCC cases (36% in men, 33% in women). HPV52 was the most commonly detected genotype, in cases and in controls. The prevalence of HPV16, HPV33, and HPV51 was significantly higher in cases than in controls (p = 0.0340, p = 0.0472, and 0.0144, respectively). Oral infection with high-risk HPV was associated with an increase in risk of HNSCC (OR 1.99, 95% CI 0.95-4.15). HPV16 was only associated with oropharyngeal cancer (OR 16.01, 95% CI 1.67-153.64). Conclusion This study revealed a high prevalence of oral HPV infection in this middle-aged Afro-Caribbean population, and a specific distribution of HPV genotypes. These findings may provide insight into HNSCC etiology specific to the FWI.
ISSN: 0957-5243

hal-01659247
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01659247
DOI : 10.1007/s10552-017-0966-z
PUBMED : 28948421

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Background: Mass breast cancer screening is offered to French women between the ages of 50 and 74. In the French overseas department of Guadeloupe, where the population is of mostly African ancestry, a low age at diagnosis of breast cancer has been reported, as for African-Americans. This raises the question of whether breast cancer is more aggressive in the age group preceding that eligible for mass screening (4049) in Guadeloupe. Methods: We compared the tumor-related prognostic factors, first line therapy and overall survival rates of breast cancer cases diagnosed between the 40-49 and 50-74 age groups, based on reports of the cancer registry of Guadeloupe for the period 2008-2013. Results: The characteristics studied, risk of death after breast cancer (HR 0.84 [95% CI: 0.58-1.22] and overall survival, did not differ significantly between the two groups, except for higher tumor size (28.8 vs 24.0; p = 0.004) in the younger group. Conclusion: These results do not show a pattern of more aggressive breast cancer in the age group preceding that eligible for mass screening in Guadeloupe. (C) 2017 Elsevier Ltd. All rights reserved.
ISSN: 1877-7821

hal-01659244
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01659244
DOI : 10.1016/j.canep.2017.08.004
PUBMED : 29120835

Éditeur(s) : HAL CCSD Advisory Council on Underwater Archaeology Publication
Résumé : International audience
This paper presents part of the results of historical research for a PhD thesis focusing on seafaring and maritime activityin Guadeloupe, French West Indies (FWI). Additionally, it discusses the possible identification of five shipwreck sitesthat appear to date to the 19th century: Anse à la Barque, Pointe-à-Pitre, Baie des Saintes, Sainte-Anne and Le Mouleshipwrecks.
ACUA Underwater Archaeology Proceedings 2014

hal-01443278
https://hal.archives-ouvertes.fr/hal-01443278
https://hal.archives-ouvertes.fr/hal-01443278/document
https://hal.archives-ouvertes.fr/hal-01443278/file/ACUA%202014%20Proceedings%20Guibert-2.pdf