Éditeur(s) : HAL CCSD
Résumé : Meteorological phenomena with scales lower than hurricanes, from extreme rainfalls to pollution peaks, represent important environmental and health risks in the Caribbean. These examples show the need to downscale large-scale meteorological data to island-scale fields.The main goal of the present numerical study is the analysis of the meso- and micro-scale mechanisms inducing diurnal and nocturnal circulations in the Guadeloupe archipelago. The Weather Research and Forecasting model is employed. The micro-scale results are obtained by the coupling of the 1-km simulated fields and the Large Eddy Simulation method. Then, in order to analyze the dispersion of a pollutants plume, the micro-scale outputs with 111 m of resolution are used to force the lagrangian particles dispersion model FLEXPART. The study has been conducted for three real cases of weather types linked with strong, medium and weak trade winds.The results of simulations, validated with available observed data, permitted to simulate all local circulations, including a nocturnal counter-current flow which may induce a pollution peak in the urban area of Pointe-à-Pitre city.These works, which may be applied to other Lesser Antilles islands, suggest many environmental and energy applications.
Les phénomènes météorologiques d'échelles inférieures aux cyclones, depuis les pluies intenses, jusqu'à la dégradation de la qualité de l'air, ont pour les Caraïbes une importance aiguë en termes de risques naturels ou de risques sur la santé. Ces exemples attestent de la nécessité d'utiliser des méthodes de descentes d'échelle pour exploiter l'information météorologique de grande échelle et dériver des scénarios locaux appliqués aux territoires insulaires. Les travaux présentés ont pour principaux objectifs la simulation numérique et l'analyse des mécanismes méso- et micro-échelles qui induisent des circulations locales diurnes et nocturnes sur l'archipel de la Guadeloupe, à l'aide du modèle numérique météorologique Weather Research and Forecasting. Les résultats des simulations micro-échelles sont obtenus par le couplage des champs modélisés à 1 km avec la méthode Large Eddy Simulation. Les sorties micro-échelles, à 111 m, sont ensuite utilisées pour forcer le modèle lagrangien de dispersion de particules FLEXPART afin d'étudier la dispersion d'un panache de polluants. L'étude a été menée pour trois cas réels de situations météorologiques correspondant à des alizés soutenus, moyens et faibles. Les résultats des simulations, après validation, et comparaison aux données d'observation disponibles, permettent de restituer l'ensemble des circulations locales et soulignent l'existence d'un écoulement nocturne à contre courant susceptible d'induire une forte pollution sur la zone urbaine de Pointe-à-Pitre. Cette étude, transposable aux autres îles des petites Antilles, laisse envisager de nombreuses applications environnementales et énergétiques.
https://hal.archives-ouvertes.fr/tel-01074600

Droits : info:eu-repo/semantics/OpenAccess
tel-01074600
https://hal.archives-ouvertes.fr/tel-01074600
https://hal.archives-ouvertes.fr/tel-01074600/document
https://hal.archives-ouvertes.fr/tel-01074600/file/rcece_thesis.pdf

Éditeur(s) : HAL CCSD
Résumé : Semi-volatile organic compounds (SVOCs) refer to a broad spectrum of molecules from different chemical families that have numerous properties. They can be used as pesticides, plasticizers, flame retardants, surfactants, lubricants, etc. Consequently, they are introduced in numerous applications in buildings or used daily by the entire population. Once emitted through evaporation or abrasion in the indoor environment or introduced from the outdoors, their chemical or biological degradation is limited, and they persist indoors. This persistence also explains why some SVOCs that were banned a few years ago are still detected in the air and dust inside buildings. In indoor environments, SVOCs are divided between the gas phase, airborne particles, and dust settled on floors and surfaces. SVOCs are of concern due to their established or suspected health effects and their widespread exposure through different environmental media and pathways. The objective of the thesis was to study the concentrations of 66 SVOCs on airborne particles (PM10) and 48 SVOCs in settled dust in two samples of dwellings randomly selected across France. PM10 were sampled during the nationwide housing survey carried out by the French Observatory of indoor air quality in 2003-2005. The dust samples were collected from vacuum cleaner bags during a nationwide survey carried out in French dwellings where at least one child aged 6 months to 6 years lived (2008-2009). The SVOCs to be analyzed had prior been selected using a ranking method based on their toxicity and indoor concentrations. The data analysis focused in particular on the identification of French specificities in terms of detected molecules and measured concentrations. It highlighted some determinants of exposure, e.g., influence of particle size, type of dust collected, dust bioaccessibility, which are not always considered and limit the comparability of results. The measured concentrations were also used to assess the health ranking implemented prior to this work and to confirm its relevance. The concentrations measured both in the air and in settled dust were compared to study the similarities in terms of concentrations and SVOC mixtures. Finally, the exposure doses to SVOCs were calculated for both a child and an adult to assess the respective contributions of inhalation and ingestion to these compounds in particulate phase in dwellings.
Les composés organiques semi-volatils (COSV) font l’objet d’une attention croissante depuis une dizaine d’années. Utilisés dans de nombreux produits et matériaux du quotidien, ils sont émis dans les bâtiments par dispersion lors de l’usage, par évaporation ou abrasion. Du fait de leurs caractéristiques physico-chimiques, ces composés se répartissent à la fois dans l’air, en phases gazeuse et particulaire, et dans les poussières déposées au sol, sur le mobilier et les objets. Compte tenu du temps passé par la population dans les bâtiments, en particulier par les populations sensibles comme les enfants, les femmes enceintes et les personnes âgées, l’exposition à ces substances mérite d’être documentée, tenant compte des voies d’exposition en jeu : inhalation, ingestion et contact cutané. La thèse a porté sur les COSV présents en phase particulaire dans les logements. L’objectif de la thèse visait à exploiter les mesures de 66 COSV dans les particules en suspension de diamètre inférieur à 10 µm (PM10) et de 48 COSV dans les poussières au sol de taille inférieure à 100 µm considérées comme étant celles adhérant à la peau. Ces mesures ont été réalisées dans le cadre de deux campagnes nationales : la campagne « Logements » de l’Observatoire de la qualité de l’air intérieur conduite en 2003-2005 et l’enquête Plomb-Habitat dont les prélèvements ont eu lieu en 2008-2009. Une hiérarchisation des molécules jugées prioritaires au regard de leur impact sanitaire potentiel avait permis au préalable d’établir la liste des COSV à mesurer. L’exploitation de ces données de contamination a notamment porté sur l’identification d’éventuelles spécificités françaises au regard des molécules en présence et/ou des concentrations mesurées. Elle a permis de mettre en lumière un ensemble de facteurs déterminants de l’exposition (influence de la taille des particules, du type de poussières collectées, de leur bioaccessibilité), qui ne sont pas toujours considérés et qui limitent par ailleurs la comparabilité des résultats. Les concentrations mesurées ont aussi permis d’évaluer rétrospectivement la hiérarchisation sanitaire et d’en confirmer la pertinence. Les concentrations des COSV quantifiés à la fois dans l’air et au sol ont été mises en perspective afin d’examiner dans quelle mesure les particules en suspension et les poussières déposées sont similaires en termes de concentrations et de mélanges de COSV en présence. Enfin, l‘estimation des doses d’exposition aux COSV à partir d’équations simples, de variables humaines d’exposition et des données de contamination a permis une première évaluation des contributions respectives de l’inhalation et de l’ingestion aux expositions domestiques des enfants et adultes à ces composés en phase particulaire.
https://tel.archives-ouvertes.fr/tel-01308524

NNT : 2015REN1B033
tel-01308524
https://tel.archives-ouvertes.fr/tel-01308524
https://tel.archives-ouvertes.fr/tel-01308524/document
https://tel.archives-ouvertes.fr/tel-01308524/file/MANDINCorinne.pdf

Éditeur(s) : HAL CCSD
Résumé : Macrophages (MΦ), well-known to play a key role in immune response, also respond to environmental toxic chemicals such as diesel exhaust particles (DEP), an air pollutant recently classified as carcinogenic to humans. MΦ are heterogeneous and plastic cells which activate according to their microenvironment into either an M1 subtype (so called classically activated or pro-inflammatory) under IFNγ and LPS stimulation or an M2 subtype (so called alternatively activated or anti-inflammatory) under IL-4 and/or IL-13 stimulation. However, potential effects of DEPs on M1/M2 MΦ polarization remain poorly documented. First, we characterized the expression marker of in vitro M-CSF-differentiated MΦ from human monocytes and activated into the M1 or M2 subtypes. Our main results show that M-CSF-generated MΦ considered as anti-inflammatory are actually able to switch to an M1 phenotype after IFNγ/LPS stimulation. Furthermore, the markers identified in this study were used to assess the impact of organic extracts of DEP (DEPe) on MΦ polarization and more generally on their physiology. DEPe alter some M1 and M2 markers expressed by polarized MΦ, without causing the overall inhibition of the M1 and M2 polarization process or the switch to a different phenotype. This phenotype alteration is associated with a decrease in the LPS-dependent inflammatory response in M1 MΦ and the chemotactic capacities in M2 MΦ. DEPe decrease the secretion of some cytokines and chemokines such as IL-6, IL-12p40 and CCL18 via AhR and/or Nrf2 activation. At the same time, we show that M1 and M2 MΦ in response to DEPe are able to secrete a sufficient level of a pro-fibrotic growth factor, the platelet derived growth factor B (PDGF-B) via AhR activation, leading to stimulation of lung fibroblast proliferation. Finally, these works show that DEPe have immunotoxic properties with regards to the physiology of human in vitro polarized MΦ. This immunotoxicity may then contribute to the deleterious effects of these urban environmental contaminants on human health.
Les macrophages (MΦ), des cellules clefs de la réponse immunitaire peuvent répondre à des contaminants environnementaux comme les particules diesel (DEP), des polluants atmosphériques récemment classés cancérigènes pour l'Homme. Les MΦ sont des cellules hétérogènes et plastiques qui s'activent en fonction de leur microenvironnement soit en MΦ M1 (dits classiquement activés ou pro-inflammatoires) sous l'effet de l'INFγ et du LPS soit en MΦ M2 (dits alternativement activés ou réparateurs) sous l'effet de l'IL-4 et/ou de l'IL-13. Les effets des DEP sur la polarisation M1/M2 des MΦ restent peu documentés. Nous avons dans un premier temps caractérisé l'expression des marqueurs des MΦ différenciés in vitro en présence de M-CSF à partir de monocytes humains et polarisés en sous-type M1 ou M2. Nos principaux résultats montrent que les MΦ différenciés au M-CSF considérés comme des MΦ anti-inflammatoires, sont en réalité capables de s'activer vers un phénotype M1 après une stimulation au LPS/IFNγ. De plus, les marqueurs mis en évidence au cours de ce travail ont permis d'évaluer l'impact d'extraits organiques de DEP (DEPe) sur la polarisation des MΦ et plus généralement sur leur physiologie. Les DEPe altèrent l'expression de certains marqueurs M1 et M2 des MΦ, sans toutefois provoquer d'inhibition globale des processus de polarisation M1 et M2 ou de transition d'un phénotype vers un autre. Cette altération du phénotype est associée à une diminution de la réponse inflammatoire LPS-dépendante dans les MΦ M1 et des capacités chimiotactiques des MΦ M2. Les DEPe diminuent la sécrétion de certaines cytokines et chimiokines comme l'IL-6, l'IL-12p40 et le CCL18 via l'activation d'AhR et/ou de Nrf2. Parallèlement, nous montrons que les MΦ M1 et M2 exposés aux DEPe sécrètent le platelet deried growth factor B (PDGF-B), un facteur de croissance profibrosant, via l'activation d'AhR en quantité suffisante pour stimuler la prolifération de fibroblastes pulmonaires. Au total, ces travaux démontrent que les DEP possèdent des propriétés immunotoxiques vis-à-vis de la physiologie des macrophages humains polarisés in vitro. Cette immunotoxicité pourrait participer aux effets délétères de ces contaminants environnementaux urbains sur la santé humaine.
https://tel.archives-ouvertes.fr/tel-01188679

NNT : 2015REN1S011
tel-01188679
https://tel.archives-ouvertes.fr/tel-01188679
https://tel.archives-ouvertes.fr/tel-01188679/document
https://tel.archives-ouvertes.fr/tel-01188679/file/JAGUIN_Marie.pdf

Éditeur(s) : HAL CCSD
Résumé : The purpose of this thesis is to improve the knowledge about and apply data mining techniques and some Bayesian model in the field of social and environmental health inequalities. On the neighborhood scale on the Paris, Marseille, Lyon and Lille metropolitan areas, the health event studied is infant mortality. We try to explain its risk with socio-economic data retrieved from the national census and environmental exposures such as air pollution, noise, proximity to traffic, green spaces and industries. The thesis is composed of two parts. The data mining part details the development of a procedure of creation of multidimensional socio-economic indices and of an R package that implements it, followed by the creation of a cumulative exposure index. In this part, data mining techniques are used to synthesize information and provide composite indicators amenable for direct usage by stakeholders or in the framework of epidemiological studies. The second part is about Bayesian models. It explains the "BYM" model. This model allows to take into account the spatial dimension of the data when estimating mortality risks. In both cases, the methods are exposed and several results of their usage in the above-mentioned context are presented. We also show the value of the socio-economic index procedure, as well as the existence of social inequalities of infant mortality in the studied metropolitan areas.
Cette thèse a pour but d'améliorer les connaissances concernant les techniques d'analyse de données et certains modèles bayésiens dans le domaine de l'étude des inégalités sociales et environnementales de santé. À l'échelle géographique de l'IRIS sur les agglomérations de Paris, Marseille, Lyon et Lille, l'événement sanitaire étudié est la mortalité infantile dont on cherchera à expliquer le risque avec des données socio-économiques issues du recensement et des expositions environnementales comme la pollution de l'air, les niveaux de bruit et la proximité aux industries polluantes, au trafic automobile ou aux espaces verts. Deux volets principaux composent cette thèse. Le volet analyse de données détaille la mise au point d'une procédure de création d'indices socio-économiques multidimensionnels et la conception d'un package R l'implémentant, puis la création d'un indice de multi-expositions environnementales. Pour cela, on utilise des techniques d'analyse de données pour synthétiser l'information et fournir des indicateurs composites utilisables directement par les décideurs publics ou dans le cadre d'études épidémiologiques. Le second volet concerne les modèles bayésiens et explique le modèle " BYM ". Celui-ci permet de prendre en compte les aspects spatiaux des données et est mis en œuvre pour estimer le risque de mortalité infantile. Dans les deux cas, les méthodes sont présentées et différents résultats de leur utilisation dans le contexte ci-dessus exposés. On montre notamment l'intérêt de la procédure de création d'indices socio-économiques et de multi-expositions, ainsi que l'existence d'inégalités sociales de mortalité infantile dans les agglomérations étudiées.
https://tel.archives-ouvertes.fr/tel-00943004

tel-00943004
https://tel.archives-ouvertes.fr/tel-00943004
https://tel.archives-ouvertes.fr/tel-00943004/document
https://tel.archives-ouvertes.fr/tel-00943004/file/Manuscrit_LallouA_final.pdf

Éditeur(s) : HAL CCSD National Institute of Environmental Health Sciences
Résumé : International audience
BACKGROUND: Women of reproductive age can be exposed to endocrine-disrupting chemicals (EDCs) at work, and exposure to EDCs in pregnancy may affect fetal growth. OBJECTIVES: We assessed whether maternal occupational exposure to EDCs during pregnancy as classified by application of a job exposure matrix was associated with birth weight, term low birth weight (LBW), length of gestation, and preterm delivery. METHODS: Using individual participant data from 133,957 mother-child pairs in 13 European cohorts spanning births from 1994 through 2011, we linked maternal job titles with exposure to 10 EDC groups as assessed through a job exposure matrix. For each group, we combined the two levels of exposure categories (possible and probable) and compared birth outcomes with the unexposed group (exposure unlikely). We performed meta-analyses of cohort-specific estimates. RESULTS: Eleven percent of pregnant women were classified as exposed to EDCs at work during pregnancy, based on job title. Classification of exposure to one or more EDC group was associated with an increased risk of term LBW [odds ratio (OR) = 1.25; 95% CI: 1.04, 1.49], as were most specific EDC groups; this association was consistent across cohorts. Further, the risk increased with increasing number of EDC groups (OR = 2.11; 95% CI: 1.10, 4.06 for exposure to four or more EDC groups). There were few associations (p < 0.05) with the other outcomes; women holding job titles classified as exposed to bisphenol A or brominated flame retardants were at higher risk for longer length of gestation. CONCLUSION: Results from our large population-based birth cohort design indicate that employment during pregnancy in occupations classified as possibly or probably exposed to EDCs was associated with an increased risk of term LBW.
ISSN: 0091-6765

hal-01405823
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01405823
DOI : 10.1289/EHP208
PUBMED : 27152464

Éditeur(s) : HAL CCSD American Meteorological Society
Résumé : Global positioning system (GPS) data from a dense network have been used for the analysis of the diurnal cycle of water vapor over Marseille, France, during the second intensive observation period (IOP2; 21–26 June 2001) of the Expérience sur Sites pour Contraindre les Modèles de Pollution Atmosphérique et de Transport d'Emission (ESCOMPTE) field experiment. Both tomographic analyses and integrated water vapor (IWV) contents from GPS have been used, in addition to wind profiler data and surface observations. Tomographic analysis of data from the dense GPS network and radiosondes provided the continuous temporal evolution of the vertical distribution of water vapor over the city of Marseille. The city is located on the shore of the Mediterranean Sea in southeastern France and is often under the influence of sea-breeze effects. Two different layers of breeze circulation are identified: a shallow sea breeze, blowing perpendicular to the local coastline, and a deep sea breeze, induced by the regional temperature gradient between sea and land. The origin of water vapor is shown to be mainly due to the advection of marine moist air by these sea-breeze circulations. However, the diurnal cycle of water vapor over Marseille is strongly influenced by the synoptic situation, which changes during the IOP2 (between a northerly mistral in the early stage of the IOP and an easterly wind at the end). It is shown that vertical profiles from tomographic analyses (combined with wind profiler data) allow for a proper interpretation of the diurnal cycle observed in IWV. Two-dimensional maps of IWV are also shown to complement the description of the horizontal advection of moisture by the different circulation regimes.
ISSN: 1558-8424

hal-00273624
https://hal.archives-ouvertes.fr/hal-00273624
https://hal.archives-ouvertes.fr/hal-00273624/document
https://hal.archives-ouvertes.fr/hal-00273624/file/drJAM_cycle_diurne_GPS_rev1.pdf
DOI : 10.1175/JAM2450.1

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Lung diseases are aggravated by exposure to diesel exhaust particles (DEPs) found in air pollution. Macrophages are thought to play a crucial role in lung immune response to these pollutants, even if the mechanisms involved remain incompletely characterized. In the present study, we demonstrated that classically and alternative human macrophages (MΦ) exhibited increased secretion of PDGF-B in response to DEP extract (DEPe). This occurred via aryl hydrocarbon receptor (AhR)-activation because DEPe-induced PDGF-B overexpression was abrogated after AhR expression knock-down by RNA interference, in both M1 and M2 polarizing MΦ. In addition, TCDD and benzo(a)pyrene, two potent AhR ligands, also significantly increased mRNA expression of PDGF-B in M1 MΦ, whereas some weak ligands of AhR did not. We next evaluated the impact of conditioned media (CM) from MΦ culture exposed to DEPe or of recombinant PDGF-B onto lung fibroblast proliferation. The tyrosine kinase inhibitor, AG1295, prevents phosphorylations of PDGF-Rβ, AKT and ERK1/2 and the proliferation of MRC5 fibroblasts induced by recombinant PDGF-B and by CM from M1 polarizing MΦ, strongly suggesting that the PDGF-BB secreted by DEPe-exposed MΦ is sufficient to activate the PDGF-Rβ pathway of human lung fibroblasts. In conclusion, we demonstrated that human MΦ, whatever their polarization status, secrete PDGF-B in response to DEPe and that PDGF-B is a target gene of AhR. Therefore, induction of PDGF-B by DEP may participate in the deleterious effects towards human health triggered by such environmental urban contaminants.
ISSN: 0041-008X

hal-01146840
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01146840
DOI : 10.1016/j.taap.2015.04.007
PUBMED : 25896968

Éditeur(s) : HAL CCSD Nature Publishing Group
Résumé : International audience
Everyone is subject to environmental exposures from various sources, with negative health impacts (air, water and soil contamination, noise, etc.or with positive effects (e.g. green space). Studies considering such complex environmental settings in a global manner are rare. We propose to use statistical factor and cluster analyses to create a composite exposure index with a data-driven approach, in view to assess the environmental burden experienced by populations. We illustrate this approach in a large French metropolitan area. The study was carried out in the Great Lyon area (France, 1.2 M inhabitants) at the census Block Group (BG) scale. We used as environmental indicators ambient air NO2 annual concentrations, noise levels and proximity to green spaces, to industrial plants, to polluted sites and to road traffic. They were synthesized using Multiple Factor Analysis (MFA), a data-driven technique without a priori modeling, followed by a Hierarchical Clustering to create BG classes. The first components of the MFA explained, respectively, 30, 14, 11 and 9% of the total variance. Clustering in five classes group: (1) a particular type of large BGs without population; (2) BGs of green residential areas, with less negative exposures than average; (3) BGs of residential areas near midtown; (4) BGs close to industries; and (5) midtown urban BGs, with higher negative exposures than average and less green spaces. Other numbers of classes were tested in order to assess a variety of clustering. We present an approach using statistical factor and cluster analyses techniques, which seem overlooked to assess cumulative exposure in complex environmental settings. Although it cannot be applied directly for risk or health effect assessment, the resulting index can help to identify hot spots of cumulative exposure, to prioritize urban policies or to compare the environmental burden across study areas in an epidemiological framework.Journal of Exposure Science and Environmental Epidemiology advance online publication, 24 September 2014; doi:10.1038/jes.2014.66.
ISSN: 1559-0631

hal-01069587
https://hal.archives-ouvertes.fr/hal-01069587
https://hal.archives-ouvertes.fr/hal-01069587/document
https://hal.archives-ouvertes.fr/hal-01069587/file/Article_multiexpo_20140708_c.pdf
DOI : 10.1038/jes.2014.66

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
People are exposed to multiple pollutants, especially indoors. In the perspective of a cumulative risk assessment, a multi-residue analytical method was developed to assess the contamination of indoor suspended particulate matter by 55 semi-volatile organic compounds (SVOCs) including musk fragrances, organochlorines (OCs), organophosphates (OPs), polycyclic aromatic hydrocarbons (PAHs), polybromodiphenylethers (PBDEs), polychlorobiphenyls (PCBs), phthalates and pyrethroids. It is based on thermal desorption (TD) coupled with gas chromatography/mass spectrometry (GC/MS). Once the thermal desorption conditions were optimized, the method was validated in terms of quantification limits and accuracy using a standard reference material (SRM 2585). Instrumental quantification limits were 10pg (some OCs, some pyrethroids, musk fragrances, OPs, PAHs, PBDEs and PCBs), 100pg (phthalates and other OCs) and 1000pg (other pyrethroids) corresponding respectively to method quantification limits of 1, 10, and 100pg/m(3) for a sampled air volume of 20m(3). Calibration quadratic curves for ranges of 10-1000, 100-10,000, and 1000-100,000pg, depending on the substance, exhibit determination coefficients above 0.999. Recoveries were between 61 and 96% for chlorinated pesticides, PAHs, PBDEs and PCBs present in the SRM 2585. A test of the method on indoor particulate matter samples (PM(10)) collected on quartz fiber filters in French dwellings demonstrated its ability to quantify SVOCs from a small amount of PM.
ISSN: 0021-9673

hal-00732133
https://hal.archives-ouvertes.fr/hal-00732133
DOI : 10.1016/j.chroma.2012.07.025
PUBMED : 22840824

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
Over the last decades, the prevalence of childhood respiratory conditions has dramatically increased worldwide. Considering the time spent in enclosed spaces, indoor air pollutants are of major interest to explain part of this increase. This study aimed to measure the concentrations of pollutants known or suspected to affect respiratory health that are present in dwellings in order to assess children's exposure. Measurements were taken in 150 homes with at least one child, in Brittany (western France), to assess the concentrations of 18 volatile organic compounds (among which four aldehydes and four trihalomethanes) and nine semi-volatile organic compounds (seven phthalates and two synthetic musks). In addition to descriptive statistics, a principal component analysis (PCA) was used to investigate grouping of contaminants. Formaldehyde was highly present and above 30 μg/m(3) in 40% of the homes. Diethyl phthalate, diisobutyl phthalate, and dimethylphthalate were quantified in all dwellings, as well as Galaxolide and Tonalide. For each chemical family, the groups appearing in the PCA could be interpreted in term of sources. The high prevalence and the levels of these compounds, with known or suspected respiratory toxicity, should question regulatory agencies to trigger prevention and mitigation actions.
ISSN: 0905-6947

hal-01162378
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01162378
DOI : 10.1111/ina.12225
PUBMED : 26010323

Éditeur(s) : HAL CCSD
Résumé : Publié en septembre 2013 dans le "Journal de Gynécologie Obstétrique et Biologie de la Reproduction" vol.42 n°5 p.413-444
We review the epidemiological literature on the possible impact of chemical and physical factors on pregnancy outcome. Effects of in-utero exposures on child health are not considered here. The highest levels of evidence concern the effects of passive smoking (on fetal growth), of lead (pregnancy-induced hypertension, fetal growth), of some Polychlorinated Biphenyls (PCB; on fetal growth) and, to a lesser extent, of atmospheric pollutants (on fetal growth and preterm delivery). For the other compounds, in particular non-persistent chemicals, the literature, which is generally based on poor exposure assessment, is less informative. In conclusion, the last decades have witnessed the development of mother-child cohorts in which exposure biomarkers have been assayed, allowing a large number of publications. For some persistent compounds, for which efficient exposure assessment approaches have been used, the literature indicates a likely impact on pregnancy outcomes. With the exception of air pollutants, the literature on non-persistent compounds is little conclusive; the assay of exposure biomarkers in repeated biological samples collected at relevant time points could help further increase knowledge regarding any health impact.
https://hal.archives-ouvertes.fr/hal-00916684

hal-00916684
https://hal.archives-ouvertes.fr/hal-00916684
https://hal.archives-ouvertes.fr/hal-00916684/document
DOI : 10.1016/j.jgyn.2013.02.012

Éditeur(s) : HAL CCSD
Résumé : International audience
BACKGROUND: Dairy working increases the prevalence of lower airway respiratory diseases, especially COPD and asthma. Epidemiological studies have reported that chronic inhalation of organic dusts released during specific daily tasks could represent a major risk factor for development of these pathologies in dairy workers. Knowledge on size, nature and biological activity of such organic dusts remain however limited. OBJECTIVE: To compare size distribution, microbial composition and cellular effects of dusts liberated by the spreading of straw bedding in five French dairy farms located in Brittany. RESULTS: Mechanized distribution of straw bedding generated a cloud of inhalable dusts in the five dairy farms' barns. Thoracic particles having a 3-7.5µm size constituted 58.9-68.3% of these dusts. Analyses of thoracic dusts by next generation sequencing showed that the microbial dust composition differed between the five French farms, although Actinobacteria, Bacteroidetes, Firmicutes and Proteobacteria represent more than 97.5% of the bacterial phyla detected in each sample. Several bacteria genera comprising of human pathogenic species, such as Pseudomonas, Staphylococcus, Thermoactinomyces or Saccharopolyspora were identified. Cladosporium and Alternaria fungal genera, which are potent environmental determinants of respiratory symptoms, were detected in dusts collected in the five farms and their levels reached 15.5-51.1% and 9-24.7% of assignable fungal sequences in each sample, respectively. Finally, all dust samples significantly and strongly increased the expression of the pro-inflammatory TNF-α, IL-1β, IL-6 and IL-8 cytokines at both mRNA and protein levels in human monocyte-derived macrophages. Their effects were dose-dependent and detectable from 1µg/ml. The intensity of the macrophage responses however differed according to the samples. CONCLUSIONS: Our results strengthen the hypothesis that organic dusts released during the distribution of straw bedding are mainly constituted of thoracic particles which are small enough to deposit on lower bronchial epithelium of dairy farmers and induce inflammation.
Environmental Research

hal-01579610
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01579610
DOI : 10.1016/j.envres.2017.07.025
PUBMED : 28735230

Résumé : La gestion du foncier martiniquais est un sujet complexe, sensible et à forte densité politique. La superficie de la Martinique est de 1 100km2, soit l’une des plus petites régions françaises, avec la plus forte densité de population, soumise à de multirisques (cyclonique, sismique, volcanique, technologique, inondation, pollution de l’air, des sols et de l’eau, tsunami…).La triangulation urbanistique composée d’une multiplicité d’acteurs, de textes et de réglementations et d’un millefeuille institutionnel (6 niveaux d’administration : commune, intercommunalité, département, région, Etat, Europe) annihile toute responsabilité et obère un développement endogène de ce micro territoire.Un juste équilibre entre développement économique, social, culturel et environnemental doit être trouvé en conciliant les objectifs économiques et sociaux liés au développement insulaire.La remarquable biodiversité de la Martinique constitue un atout touristique indéniable, menacé par de fortes pressions anthropiques foncières.Cette recherche démontre la pertinence de la réglementation applicable au foncier à la Martinique et l’influence du développement durable sur cette réglementation. La thèse propose des solutions pérennes à mettre en œuvre pour pallier les incohérences juridiques révélées par l’étude.
Management of land in Martinique is a complex, sensitive and highly political topic.The total area of the island is 1 100 km2 (square meters), e.g, one of the smallest French areas, with the highest concentration of population, submitted to multirisk desasters (cyclonic, seismic, volcanic, technological, flood, air, ground and water pollutions, tsunami…).The urban triangulation made up of a multiplicity of actors, texts and regulations, as well as a multi-level institutional cream cake (6 levels of administration: the city, the intercity, the Department, the Regional Council, the State and Europe), destroys all kind of responsibility and obstruct an endogenous development of this micro territory.A fair balance between economic, social, cultural and environmental development is necessary, by reconciling with the economic and social goals related to the insular development.The astonishing biodiversity of the island of Martinique represents an obvious tourist asset, threatened by strong land anthropic pressures.This research study highlights the relevance of the regulation applicable to the land in Martinique as well as the influence of sustainable development on this regulation. This thesis suggests perennial solutions to implement, in order to mitigate the legal inconsistencies pointed out by the study.

http://www.theses.fr/2011AGUY0503/document

Éditeur(s) : HAL CCSD
Résumé : International audience
To study the associations between occupation, industry and prostate cancer risk in Guadeloupe, a high incidence area. Incident cases of prostate cancer (707 cases) and 722 population controls were included. Information on lifetime occupational history and other potential risk factors was collected by interview. Logistic regression was used to estimate adjusted odds-ratios (OR) and their 95% confidence intervals (CI). A significantly decreased risk was observed in farmers (OR=0.5; CI 0.4-0.7), whereas marginally elevated ORs were found for farm workers, especially in sugarcane and banana farming. Banana plantation workers had been exposed to chlordecone, an estrogenic insecticide previously found to be associated with prostate cancer risk in this population. Significantly increased risks of prostate cancer were found in stock clerks (OR=2.7; CI 1.0-7.2), fishermen (OR=2.0; CI 1.0-4.0), mail distribution clerks (OR=7.7; CI 1.7-34.4) and electricians employed for more than 20 years (OR=4.0; CI 1.0-15.8), as well as in public administration (OR=1.8; CI 1.2-2.9), retail trade (OR=2.6; CI 1.1-6.0) and manufacture of food products (OR=2.0; CI 1.1-3.9), particularly sugar (OR=13.2; IC 1.6-108). Non-significantly elevated ORs were also seen for construction workers and transport equipment operators. Although the overall findings suggest that occupational factors have only a limited role in prostate cancer aetiology, elevated risks of prostate cancer were found in several occupations or industries. Exposure to pesticides, solvents, traffic-related air pollution, low physical activity, whole-body vibration may explain some of these increased risks.
Challenges for Occupational Epidemiology in the 21st Century EPICOH 2014
Chicago, United States

hal-01118558
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118558
DOI : 10.1136/oemed-2014-102362.312
PUBMED : 25018167

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Formaldehyde (FA) is a volatile organic compound (VOC), considered as a major indoor air pollutant and suspected to favor the development of inflammatory lung diseases. The present study was aimed at identifying cytokines/chemokines targeted by FA in human lung cells. This VOC was demonstrated to up-regulate interleukin-11 (IL-11) mRNA and secretion levels in a dose-dependent manner in cultured lung epithelial BEAS-2B cells. It concomitantly induced mRNA expression of transforming growth factor (TGF)-β1, a fibrogenic marker regulated by IL-11. FA was also found to trigger an early phosphorylation of p38 and extracellular signal-regulated kinase (ERK)1/2 mitogen-activated protein kinases (MAPKs) in BEAS-2B cells, whose inhibition by ERK and p38 MAPK chemical inhibitors (U0126 and SB203580, respectively) counteracted FA-mediated induction of IL-11. In addition, FA increased phosphorylation of cAMP response element binding protein (CREB) and the use of small-interfering RNA targeting CREB demonstrated that this transcription factor was required for the up-regulation of IL-11 by FA. Implication of protein kinase C (PKC) in FA-induced IL-11 expression was moreover demonstrated by using RO-31-8220, a PKC inhibitor. We finally showed using SB203580 and RO-31-8220 that phosphorylation of CREB and CREB-promoter activity induced by FA are under the control of both p38 MAPK and PKC. Taken together, the results showed that FA uses different pathways to induce IL-11 expression in lung BEAS-2B cells. IL-11, well-known to contribute to lung inflammatory diseases, appears thus as a molecular target of FA, which could be involved in putative deleterious inflammatory and fibrogenic pulmonary effects of this VOC.
ISSN: 0300-483X

hal-00682486
https://hal.archives-ouvertes.fr/hal-00682486
DOI : 10.1016/j.tox.2011.11.011
PUBMED : 22138297

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
Scientific interest in urban meteorology has increased because highly populated areas experience high vulnerability to pollution or heavy rain. However, compared to urban air quality or urban heat island (UHI) processes, the urban water vapour cycle is poorly understood because it has been investigated less due to the lack of upper-air measurements and the high sensitivity of surface measurements to local heterogeneities. In this paper, surface measurements of wind, temperature, pressure and humidity, as well as integrated water vapour (IWV) from GPS and MODIS and numerical simulations, have been used to investigate the urban cycle of water vapour in May and June 2004 during the VAPIC field experiment in the Paris area. The surface data show the typical characteristics of an urban area with the absence of water vapour sources and a UHI of about 6 °C at night. The urban IWV distribution differs completely, with an urban IWV excess on average between 1600 and 0600 UTC (with a maximum of about 1.5 kg m−2 at 0600 and 1700 UTC). No IWV difference between the urban and rural areas is found in the middle of the day. The numerical simulations reproduce accurately the urban IWV anomaly. Shallow surface wind convergence associated with the UHI during nighttime provides moisture from the rural areas. Urban areas are therefore under wind convergence for most of the time. The rural water vapour sources and the depth of the convergence control the amplitude of the urban IWV excess. At about 1200 UTC, entrainment at the top of the urban boundary layer is the key process that inhibits the urban IWV excess observed at night
ISSN: 0035-9009

hal-00406370
https://hal.archives-ouvertes.fr/hal-00406370
DOI : 10.1002/qj.446

Éditeur(s) : HAL CCSD
Résumé : International audience
Semi-volatile organic compounds (SVOCs) partition indoors between the gas phase, airborne particles, settled dust, and other surfaces. Unknown concentrations of SVOCs in the gas phase (Cg) can be predicted from their measured concentrations in airborne particles. In previous studies, the prediction of Cg depended largely on choosing a specific equation for the calculation of the particle/gas partition coefficient. Moreover, the prediction of Cg is frequently performed at a reference temperature rather than the real indoor temperature. In this paper, a probabilistic approach based on Monte Carlo simulation was developed to predict the distribution of SVOCs' Cg from their concentrations in airborne particles at the target indoor temperature. Moreover, the distribution of the particle/gas partition coefficient of each SVOC at the target temperature was used. The approach was validated using two measured datasets in the literature: the predicted Cg from concentrations measured in airborne particles and the measured Cg were generally of the same order of magnitude. The distributions of the Cg of 66 SVOCs in the French housing stock were then predicted. The SVOCs with the highest median Cg, ranging from 1 ng/m3 to > 100 ng/m3, included 8 phthalates (DEP, DiBP, DBP, DEHP, BBP, DMP, DiNP, and DMEP), 4 polycyclic aromatic hydrocarbons (fluorene, phenanthrene, fluoranthene, and anthracene), 2 alkylphenols (4-tert-butylphenol and 4-tert-octylphenol), 2 synthetic musks (galaxolide and tonalide), tributyl phosphate, and heptachlor. The nationwide, representative, predicted Cg values of SVOCs are frequently of the same order of magnitude in Europe and North America, whereas these Cg values in Chinese and Indian dwellings and the Cg of polybrominated diphenyl ethers in U.S. dwellings are generally higher. © 2016 Elsevier B.V.
Science of the Total Environment

hal-01467547
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01467547
DOI : 10.1016/j.scitotenv.2016.10.074
PUBMED : 27788447

Résumé : La forêt tropicale humide guyanaise est située dans le grand ensemble Amazonien, qui est un point chaud des enjeux sur la biodiversité et la conservation des forêts tropicales. Une connaissance de l’âge et des taux d’accroissement des arbres est primordiale pour comprendre la dynamique de ces écosystèmes Cependant, l’absence de conditions hivernales sous les tropiques rend difficile la lecture de l’histoire dans les bois de ces forêts. En se plaçant dans le champ de l’anatomie fonctionnelle, cette thèse à caractère exploratoire avait pour but, à travers différentes approches, i) de suivre l’activité cambiale de quatre espèces ligneuses durant deux ans par prélèvements de micro-carottes, ii) de faire une étude dendrochronologique sur une espèce guyanaise, iii) d’utiliser la variation de la signature isotopique comme marqueur de croissance (ou d’histoire) et iv) de tester la pollution aérienne consécutive aux lancements de la fusée Ariane comme marqueurs de la croissance. L’examen bi-mensuel de l’activité cambiale a montré que tous les arbres présentent des alternances de quasi repos et de forte activité du cambium durant les deux années. Ces périodes de ralentissement ont été plus marquées chez Parkia nitida (décidue), Parkia velutina (décidue) et Schefflera morototoni (sempervirente). On observe donc des périodes de ralentissement de l’activité du cambium aussi bien chez deux espèces décidues que chez une espèce sempervirente. Il n’y a pas de patron universel de liaisons deux à deux entre pluviométrie intra-annuelle, phénologie de la feuillaison et activité cambiale même si des analogies fortes existent au cas par cas entre deux espèces pour une relation donnée. L’étude dendrochronologique chez Parkia nitida a mis en évidence la présence de cernes de croissance bien distincts et annuels. La limite de cerne se caractérise par une fine bande de parenchyme marginal renfermant de nombreux cristaux d’oxalate de calcium. A l’échelle de l’arbre, la croissance secondaire est homogène et elle est relativement synchrone au sein d’individus de cette espèce dans le même lieu. Cependant, l’influence des paramètres climatiques testés, comme la température et les précipitations, sur la croissance radiale annuelle est faible sur la période considérée. Ces deux premières études montrent que, dans le contexte de la Guyane française, la saisonnalité annuelle très marquée de la pluviométrie ne se traduit pas par un signal suffisamment fort pour synchroniser l’ensemble du fonctionnement des arbres. Néanmoins, elle influence clairement, au cas par cas soit la feuillaison, soit la floraison, soit la croissance cambiale. Les autres méthodes de marquage de la croissance (i.e. isotopie et chimie) entreprises demandent à être approfondies. Les bois des espèces de forêt tropicale humide se caractérisant en moyenne par un pourcentage élevé du plan ligneux occupé par les parenchymes axiaux, il serait important d’entreprendre une étude approfondie de leur rôle en tant qu’accumulateurs de substances potentiellement utiles pour la défense du bois dans l’arbre contre les xylophages. L’évolution dans le temps (périodicité, vieillissement chimique) des solutions de défense mises en place dans le bois est une piste intéressante pour la dendrochronologie
The rainforest of French Guiana is located in the Amazonian region, which is a hotspot of biodiversity, thus leading to several issues about conservation in tropical forests. Knowledge of the age and growth rate of trees is essential to understand the dynamics of these ecosystems. However, due to the lack of winter conditions it is difficult to read the story in the wood of these tropical forests. In the topic of functional anatomy, this thesis intends through different approaches i) to monitor the cambial activity of four tree species during two years sampling micro-cores, ii) to make a dendrochronological study on a Guyanese species iii) to use the variation of the isotopic signature as a marker of growth (or history) and iv) to test air pollution following launches of the Ariane rocket as markers of growth. The bi-monthly review of cambial activity showed that all trees have almost alternating rest and high activity of cambium in both years. These downturns have been more pronounced in Parkia nitida (deciduous), Parkia velutina (deciduous) and Schefflera morototoni (evergreen). We observe periods of cambial activity downturn in two deciduous species as well as in an evergreen species. There is no universal pattern of connections in pairs between rainfall intra-annual phenology of leafing and cambial activity although strong similarities exist in each case between two species for a given association. The dendrochronological study in Parkia nitida highlights the presence of distinct annual growth rings. The limit is characterized by a thin band of marginal parenchyma containing numerous crystals of calcium oxalate. At tree scale, secondary growth is homogeneous and relatively synchronous within individuals of this species in the same location. However, the influence of tested climatic parameters, such as temperature and precipitation on the annual radial growth, is low over the considered period. The first two studies showed that, in the environment of French Guiana, marked annual seasonality of rainfall does not affect in a strong way the behavior of the trees. Nevertheless, those rainfalls have an influence either on leafing, flowering or cambial growth. Other methods of marking growth (i.e. isotopic and chemical) intended require further investigations. Axial parenchyma represents a high average percentage in the wood of rainforest species: it could be important to investigate more precisely its role as accumulators of potentially useful substances involved in wood defense against borers. The evolution throughout time (periodicity, chemical aging) of defense mechanisms in woods is an interesting way for dendrochronology.

http://www.theses.fr/2013AGUY0605/document

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Several studies have documented that more deprived populations tend to live in areas characterized by higher levels of environmental pollution. Yet, time trends and geographic patterns of this disproportionate distribution of environmental burden remain poorly assessed, especially in Europe. We investigated the spatial and temporal relationship between ambient air nitrogen dioxide (NO2) concentrations and socioeconomic and demographic data in four French metropolitan areas (Lille in the North, Lyon in the center, Marseille in the South, and Paris) during two different time periods. The geographical unit used was the census block. The dependent variable was the NO2 annual average concentration (μg/m(3)) per census block, and the explanatory variables were a neighborhood deprivation index and socioeconomic and demographic data derived from the national census. Generalized additive models were used to account for spatial autocorrelation. We found that the strength and direction of the association between deprivation and NO2 estimates varied between cities. In Paris, census blocks with the higher social categories are exposed to higher mean concentrations of NO2. However, in Lille and Marseille, the most deprived census blocks are the most exposed to NO2. In Lyon, the census blocks in the middle social categories were more likely to have higher concentrations than in the lower social categories. Despite a general reduction in NO2 concentrations over the study period in the four metropolitan areas, we found contrasting results in the temporal trend of environmental inequalities. There is clear evidence of city-specific spatial and temporal environmental inequalities that relate to the historical socioeconomic make-up of the cities and its evolution. Hence, general statements about environmental and social inequalities can be made.
ISSN: 0013-9351

hal-01063900
https://hal.archives-ouvertes.fr/hal-01063900
DOI : 10.1016/j.envres.2014.07.017
PUBMED : 25199972

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Decreasing growth rate (Feeley et al., 2007) and large die-back due to drought (Phillips et al., 2009) suggest that tropical forests are suffering recent climate changes. Forest vulnerability to external factors (e.g. air pollution, acid rain) is widely studied in northern countries, while only a few attempts have investigated crown integrity in the Tropics. The method needs to be generic enough to account for the large number of species and crown shapes encountered in tropical forests. In the present study, we developed and tested a novel field method that estimates crown fragmentation (main branch mortality (MB) and secondary branch mortality (SB)), liana infestation (LI) and crown position (CP) in the canopy. The relationship between crown fragmentation and annual growth rate (agr) was investigated through multiple regression. Six out of eight canopy tree species showed significant growth decline with increasing crown fragmentation. Higher probability of death was also found in trees with severe crown fragmentation. The capacity of such crown assessment to depict tree vitality in a forest stand is discussed along with potential applications in both forest science and management
ISSN: 0378-1127

halsde-00611465
https://hal.archives-ouvertes.fr/halsde-00611465
DOI : 10.1016/j.foreco.2010.10.025