Éditeur(s) : HAL CCSD springer Link
Résumé : International audience
Experimental Astronomy

hal-01094521
https://hal.archives-ouvertes.fr/hal-01094521
BIBCODE : 2014ExA...tmp...41R
DOI : 10.1007/s10686-014-9383-4
ARXIV : 1310.0696

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
This study aimed to identify factors associated with virological response (VR) to raltegravir (RAL)-containing regimens in 468 treatment-experienced but integrase inhibitor-naive HIV-1 patients receiving a RAL-containing regimen. VR was defined at Month 6 (M6) as HIV-1 RNA viral load (VL) <50 copies/mL. The impacts on VR of baseline integrase mutations, VL, CD4 count, genotypic sensitivity score for nucleoside reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors and protease inhibitors, and the number of new antiretrovirals used for the first time associated with RAL were investigated. For patients with VL >50 copies/mL at M6, integrase mutations selected were characterised. Median baseline VL was 4.2 log(10)copies/mL (IQR 3.3-4.9 log(10) copies/mL) and CD4 count was 219 cells/mm(3) (IQR 96-368 cells/mm(3)). At M6, 71% of patients were responders. In multivariate analysis, baseline VL and CD4 count and ≥ 2 new antiretrovirals among darunavir, etravirine, maraviroc and enfuvirtide were associated with VR to RAL. Neither HIV-1 subtype nor baseline integrase polymorphisms were associated with VR to RAL. Among 63 failing patients at M6, selection of ≥ 1 change in the integrase gene was observed in 49 (77.8%), and 27/63 (42.9%) were considered as RAL-associated resistance mutations. Factors independently associated with the occurrence of ≥ 1 RAL-associated resistance mutation were VL at failure >3 log(10) and having no new drugs associated with RAL. RAL showed great potency in treatment-experienced patients. The number of new drugs associated with RAL was an important factor associated with VR. HIV-1 subtype and baseline integrase polymorphisms do not influence the RAL VR.
ISSN: 0924-8579

hal-00875083
https://hal.archives-ouvertes.fr/hal-00875083
DOI : 10.1016/j.ijantimicag.2013.02.016
PUBMED : 23562640

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
We investigate the timing of end of motion along the South Tibet Detachment System (STDS), a major normal fault system that runs parallel to the Himalayan range for more than 1500 km. Near Dinggye (similar to 28 degrees 10'N, 87 degrees 40'E), the STD dips similar to 10 +/- 5 degrees to the North and separates Paleozoic Tethyan series from Upper Himalayan Crystalline Series (UHCS). Immediately below the STD, the UHCS is highly deformed in the STD shear zone, lineations trend NNE and the shear senses are top to the NE. In micaschist, the P-T path constrained by pseudosection and garnet chemistry, shows successive metamorphic conditions of similar to 0.6 GPa and similar to 550 degrees C and 0.5 GPa and 625 degrees C. U/Pb dating of monazites and zircons in deformed and undeformed leucogranites suggests that ductile deformation lasted until at least similar to 16 Ma but ended prior to similar to 15 Ma in the STD shear zone similar to 100 m below the detachment. Ar/Ar micas ages in the footwall span between similar to 14.6 and 13.6 Ma, indicating rapid cooling down to similar to 320 degrees C, and suggesting persistence of normal faulting, at that time. The STDS is cut and offset by the N-S trending Dinggye active normal fault which initiated prior to 11 Ma thus providing a minimum bound for the end of STDS motion. These data are interpreted as reflecting 0.3 GPa (11 km) to 0.6 GPa (22 km) of exhumation along the STDS starting prior to similar to 16 Ma, ending between 13.6 and 11 Ma. The 1000 km long stretch of the STDS east of the Gurla Mandata probably stopped almost synchronously between 13 and 11 Ma ago, coevally with a sudden switch from NNE-SSW to E-W extension at the top of the accretionary prism, with a jump of the major thrust from the lower Main Central Thrust (MCTI) to the Main Boundary Thrust (MBT), and with a change in the India and Asia convergence direction. This synchronism is probably better explained in the frame of a thrust wedge or thrust system model than a lower channel flow model. West of the Gurla Mandata the STDS appears to stop 5 to 3 Ma earlier, possibly related to local interactions with the Karakorum fault in a way that needs to be understood.
ISSN: 0012-821X

hal-00475652
https://hal.archives-ouvertes.fr/hal-00475652
DOI : 10.1016/j.epsl.2009.12.035

Éditeur(s) : HAL CCSD Société géologique de France
Résumé : In the western Mediterranean Sea, the Liguro-Provençal Basin (LPB) is a key area for studying passive margins because of its recent formation and abundance of onshore and offshore data. The Nerthe area located in the northern margin of LPB provides the unique continuous Oligo-Miocene deposits contemporaneous of the transition rifting to drifting. However, the age of the deposits remains debated and the link between outcrops and offshore seismic data is poorly constrained. The purpose of this paper is double. First, we intend to propose a new chronostratigraphic frame based on bio- (planktonic foraminifera, calcareous nannofossils) and magneto-stratigraphy. Second, we aim to make, through the integration of new highly time-resolved seismic data and field works, a coherent onshore-offshore link concretized by a 3D geological model. The new temporal and spatial data presented in this paper allow correlating the Oligo-Miocene sequences, defining their geometry and specifying precisely the timing of syn- and post-rift stages. The first marine transgression is now precisely dated latest Chattian within the syn-rift deposits and appears to be synchronous with the first marine deposits in the offshore wells and other marginal basins. The transition from syn-rift to post-rift appears to last 3.3 Ma at maximum, between 21.8 and 18.5 Ma (late Aquitanian to early Burdigalian). It is underlined by two major erosional unconformities bearing a hiatus of around 1 Ma. The post-rift started with a major marine transgression that is now dated from middle Burdigalian, at around 18.5 Ma, as elsewhere in the LPB. Contrarily to recent proposals, the post-rift deposits are widely represented on the northeastern margin of the "Golfe du Lion". There, the subsidence of the margin was low during the syn-rift and the transitional periods and high during the post-rift. The onset of this high post-rift subsidence appears to be synchronous with the slowdown of the Corsica-Sardinia block (CSb) motion.
EISSN: 1777-5817

hal-00558497
https://hal.archives-ouvertes.fr/hal-00558497
DOI : 10.2113/gssgfbull.181.6.591

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : Reconstruction of Northern African monsoon between 6.2 and 4.9 Ma and possible relationships with Late Miocene events. Mineralogical and geochemical investigations have been realized on ODP Site 659 in order to better understand the detrital sedimentation of the Cap Verde plateau and to reconstruct African monsoon intensity variations between 6.2 and 4.9 Ma. Time intervals corresponding to an intensification of the summer African monsoon rainfall are associated to a reduction of eolian input from the Sahara and an intensification of the African river input. The reflooding of the Mediterranean Sea at the end of the Messinian salinity crisis (MSC) (5.33 Ma) is correlated to a greater aridity in the Sahara.
ISSN: 1631-0713

hal-00412151
https://hal.archives-ouvertes.fr/hal-00412151
DOI : 10.1016/j.crte.2008.07.005

Éditeur(s) : HAL CCSD Wiley
Résumé :  
Aims: Astrocaryum sciophilum (Miq.) Pulle (Arecaceae) is an understorey palm, endemic to north-eastern South America with a patchy distribution. We tested the hypothesis that the spatial distribution of this palm species is not in equilibrium but is slowly colonizing the forest understorey. Location: Inventories and seed dispersal studies were conducted in the undisturbed tropical forest close to the Nouragues research station, French Guiana. Additional data were collected in the entire territory of French Guiana. Methods: We studied the demography of A. sciophilum on a 20-ha plot located at the edge of its distribution. The age of the palms was estimated by postulating an exponentially decreasing abundance by age class. Direct seed dispersal experiments were also conducted, to estimate dispersal parameters. The seeds of A. sciophilum were dispersed only by rodents. This information was used to parameterize a forest growth simulator, to study the spatial spread of this species. Results: Within the sampling plot, the density of A. sciophilum dropped sharply from about 500 individuals per hectare to zero. The maturation age was estimated to be 170 ± 70 years, and over 55 years with 95% confidence. Seed-dispersal experiments yielded an average seed dispersal distance of 11 m and a maximum estimated dispersal distance of 125 m across a generational span of 55 years to maturity. Therefore, the maximal estimated colonization speed is 2.3 m/y. Conclusions: Empirical results and numerical simulations suggest that the boundary of the A. sciophilum population is a colonization front, and that the range of this species is slowly expanding. The implications of this result in respect of palaeoenvironmental changes in this region are discussed.
ISSN: 1466-822X

hal-01032154
https://hal.archives-ouvertes.fr/hal-01032154
DOI : 10.1046/j.1466-822X.2003.00020.x

Éditeur(s) : American Geophysical Union
Résumé : [1] A multiproxy integrated chronological framework, based on oxygen and carbon stable isotope stratigraphy, biostratigraphy (foraminifera and nannoplankton bioevents and foraminifer assemblage-based climate cyclicity), magnetostratigraphy, sapropel stratigraphy, and C-14 AMS radiometric dates, has been achieved for borehole PRAD1-2, collected in 185.5 m water depth in the central Adriatic. This work was carried out within the European Community project Profiles across Mediterranean Sedimentary Systems (PROMESS1). The 71.2 m long borehole spans a time interval between late MIS 11 and MIS 1 (the last 370 ka), showing a chronological resolution of 500 and 250 years per cm during interglacial and glacial intervals, respectively. At present, this record is the most expanded and continuous marine record available for the Adriatic Basin. Several orbital cycles can be recognized in the PRAD1-2 record: the 100 ka glacial-interglacial fluctuations and the 23 ka precession-related cycles, which in turn control the deposition of sapropel layers. An integrated analysis of short-term oscillations within the Last Glaciation interval (MIS 4-MIS 2) allowed the identification of the Adriatic signature of Dansgaard-Oeschger events, showing the potential to achieve a more refined chronostratigraphic framework for the top part of the PRAD1-2 record. Finally, the age model obtained by this study allowed the chronological integration of the main foraminifera bioevents detected in the borehole as well as of the volcanoclastic layers present in the upper part of the record. Despite its proximal location, PRAD1-2 presents a continuous record and shows the potential to be consistently correlated both with deep-sea and continental records in the Mediterranean region and beyond.
Geochemistry Geophysics Geosystems (1525-2027) (American Geophysical Union), 2008 , Vol. 9 , P. NIL_107-NIL_127

Droits : 2008 American Geophysical Union
http://archimer.ifremer.fr/doc/2008/publication-3605.pdf
DOI:10.1029/2007GC001713
http://archimer.ifremer.fr/doc/00000/3605/

Éditeur(s) : HAL CCSD Elsevier
Résumé :  
absent
Ecology and management of a neotropical rainforest: lessons drawn from Paracou, a long-term experimental research site in French Guiana

ISBN : 2-84299-455-8
hal-01189214
https://hal.archives-ouvertes.fr/hal-01189214
PRODINRA : 16123

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
BACKGROUND: The potential interest of antifungal treatment of non-immunocompromized patients with sepsis, extra-digestive Candida colonization and multiple organ failure is unknown. It represents three-quarters of antifungals prescribed in Intensive Care Units. It may allow early treatment of invasive fungal infection in the incubation phase but expose patients to unnecessary antifungal treatments with subsequent cost and fungal selection pressure. As early diagnostic tests for invasive candidiasis are still considered to be insufficient, the potential interest in this strategy needs to be demonstrated. METHODS: This prospective multicenter, double blind, randomized-controlled trial is conducted in 23 French Intensive Care Units. All adult patients, mechanically ventilated for more than four days with sepsis of unknown origin and with at least one extradigestive fungal colonization site and multiple organ failure are eligible for randomization. Patients with proven invasive candidiasis are not included. After a complete mycological screening, patients are allocated to receive micafungin 100 mg intravenously once a day or placebo for 14 days. We plan to enroll 260 patients. The main objective is to demonstrate that micafungin increases survival of patients without invasive candidiasis at day 28 as compared to placebo. Other outcomes include day 28 and 90 survival and organ failure evolution. Additionally, pharmacokinetics of micafungin in enrolled patients will be measured and evolution of fungal biomarkers and susceptibility profiles of infecting fungi will also be followed. DISCUSSION: This study will help to provide guidelines for treating non-immunocompromized patients with fungal colonization multiple organ failure and sepsis of unknown origin.Trial registration: Clinicaltrials.gov number NCT01773876.
ISSN: 1745-6215

inserm-00913515
http://www.hal.inserm.fr/inserm-00913515
http://www.hal.inserm.fr/inserm-00913515/document
http://www.hal.inserm.fr/inserm-00913515/file/1745-6215-14-399.pdf
PUBMED : 24261608

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
To test the impact of fluid flow on the reactivity of porous (ultra-)mafic rocks, reactive percolation experiments were realized during which CO2-enriched water was injected at two different injection rates (Q = 0.1 and 1 mL h−1) through sintered analogues of olivine-accumulation zones in basaltic flows at temperature and fluid composition conditions (T = 180 °C; NaHCO3 buffered solution) favorable for CO2-mineralization (carbonation).All experiments resulted in silicate dissolution, carbonate precipitation upstream and (proto-)serpentine formation downstream indicating a decrease in the fluid reactivity along flow paths. The measured bulk carbonation rates ranged from 4 to 7 × 10−8 s−1; these values were significantly lower than previously published values of olivine carbonation rate obtained on powders in closed batch and flow-through reactors. Our study show complex couplings, at pore scale, between fluid flow, localization of reaction zones, and chemical reaction kinetics which in turn control hydrodynamic properties, carbonation rate and efficiency and fluid reactivity. This results in carbonation rates being higher when injection rates are high and permeability ultimately controlling carbonation reactions by limiting fluid input. During experiments, notable changes in permeability occurred for only minor changes in porosity indicating a control by the geometry of the porous network: heterogeneities in the distribution of flow paths favored the localization of precipitated minerals which in turn resulted in the closure of flow paths. This mechanism was particularly efficient at low injection rates. These results imply that controlling the injection rate could allow enhancing/limiting the efficiency of in situ carbonation.
ISSN: 0883-2927

hal-01115284
https://hal.archives-ouvertes.fr/hal-01115284
DOI : 10.1016/j.apgeochem.2014.11.024

Éditeur(s) : Gauthier-villars
Résumé : The new bathymetric, magnetic and mainly seismic data acquired during the Zoesis cruise, reveal the presence of compressional features in the ''Fairway Ridge-Fairway Basin-Lord Howe Rise (northern part)'' area, west of New Caledonia. The compressive strain is especially responsible for the formation of the Fairway Ridge. The compression is emphasized by a regional unconformity that could be dated late Eocene, according to DSDP data in the area, and therefore synchronous with the late Eocene obduction of the New Caledonia ophiolites. The westward extension of the late Eocene compressive strain in the New Caledonia area is more developed than previously thought.
De nouvelles données bathymétriques, magnétiques et principalement de sismique réflexion, recueillies durant la campagne Zoesis, révèlent l'existence de figures compressives à l'ouest de la Nouvelle-Calédonie, a travers l'ensemble <( ride de Fairway - bassin de Fairway - partie nord de la ride de Lord Howe D. La tectonique compressive, en particulier responsable de la formation de la ride de Fairway, est soulignée par une discordance régionale qui, compte tenu des données de forages DSDP sur la région, serait d'âge Eocene supérieur et donc synchrone du charriage de la nappe ophiolitique sur le bâti Calédon&. Les effets de I'épisode compressif fini-éocène qui affecte la Nouvelle-Calédonie sont ressentis bien plus à l'Ouest que précédemment supposé.
Comptes Rendus de l'Academie des Sciences Serie II (1251-8069) (Gauthier-villars), 1994-11 , Vol. 319 , N. 9 , P. 1063-1069

Droits : Académie des Sciences
http://archimer.ifremer.fr/doc/00183/29457/27888.pdf
http://archimer.ifremer.fr/doc/00183/29457/

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
Two types of olivine occur in kimberlites from Greenland, Canada and southern Africa. The first, xenocrystic olivine, displays several different forms. Most distinctive are 'nodules', a term we use to describe the large (1-5 mm), rounded, single crystals or polycrystalline aggregates that are a common constituent of many kimberlites. Olivine compositions are uniform within single nodules but vary widely from nodule to nodule, from Fo81 to 93. Within many nodules, sub- to euhedral asymmetric tablets have grown within larger anhedral olivine grains. Dislocation structures, particularly in the anhedral grains, demonstrate that this olivine was deformed before being incorporated into the kimberlite magma. Olivine grains in the kimberlite matrix between the nodules have morphologies similar to those of the tablets, suggesting that most matrix olivine grains are parts of disaggregated nodules. We propose that a sub- to euhedral form is not sufficient to identify phenocrysts in kimberlites and provide some criteria, based on morphology, internal deformation and composition, that distinguish phenocrysts from xenocrysts. The second type of olivine is restricted to rims surrounding xenocrystic grains. Only this olivine crystallized from the kimberlite magma. Major and trace element data for the rim olivine are used to calculate the composition of the parental kimberlite liquid, which is found to contain between about 20 and 30% MgO. The bulk compositions of many kimberlites contain higher MgO contents as a result of the presence of xenocrystic olivine. The monomineralic, dunitic, character of the nodules, and the wide range from Fo-rich to Fo-poor olivine compositions, provide major constraints on the origin of the nodules. Dunite is a relatively rare rock in the mantle and where present its olivine is persistently Fo-rich. The dunitic source of the nodules in kimberlites lacked minerals such as pyroxene and an aluminous phase, which make up about half of most mantle-derived rocks. It appears that these minerals were removed from the mantle peridotite that was to become the source of the nodules, and the Fo content of the retained olivine was modified during interaction with CO2-rich fluids whose arrival at the base of the lithosphere immediately preceded the passage of the kimberlite magmas. Fragments of the resultant dunite were entrained into the kimberlite, where they were retained both as intact nodules and as disaggregated grains in the matrix.
ISSN: 0022-3530

insu-00543321
https://hal-insu.archives-ouvertes.fr/insu-00543321
BIBCODE : 10.1093/petrology/egp080
DOI : 10.1093/petrology/egp080

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : International audience
Late Jurassic coral reefs are present in the Western High Atlas of Morocco along the eastern paleomargin of the young Atlantic Ocean. The Izwarn section shows two reef units made of scleractinian corals and microbialites, included in a progradational shallowing-upward succession. Changes in reefal composition and structure observed in a ca. 50 cm-thick interval at the base of the reef unit 1 are interpreted to represent the first well-documented ecological succession in Late Jurassic reefs. Bioclastic deposits, sparse and poorly diversified corals (five genera) preserved in life position, and finally a more diversified coral assemblage (11 genera) building a reef framework with stromatolitic crusts reflect pioneer, colonization and diversification stages, respectively. A specific depth window, where light was reduced but sufficient for a catch-up growth mode and below the erosive action of waves, probably at the lower slope of a fore-reef area, has made possible the development and the record of this ecological succession. With a more diversified coral assemblage (16 genera), the reef unit 2 reflects shallower and well-agitated waters of a fore-reef area. Overlaying this second reef unit, the upper part of the section reveals back-reef deposits made of reworked reef elements, whereas a putative reef crest area is not recorded.
ISSN: 0016-6995

hal-00795549
https://hal.archives-ouvertes.fr/hal-00795549
DOI : 10.1016/j.geobios.2012.05.002

Éditeur(s) : HAL CCSD BMJ Publishing Group
Résumé : For the ICARE Study Group
International audience
Objective Our objective was to investigate the association between head and neck cancer and occupational exposure to chlorinated, oxygenated and petroleum solvents in women.Methods Investigation of occupational and environmental CAuses of REspiratory cancers (ICARE), a French population-based case–control study, included 296 squamous cell carcinomas of the head and neck (HNSCC) in women and 775 female controls. Lifelong occupational history was collected. Job-exposure matrices allowed to assess exposure to 5 chlorinated solvents (carbon tetrachloride; chloroform; methylene chloride; perchloroethylene; trichloroethylene), 5 petroleum solvents (benzene; special petroleum product; gasoline; white spirits and other light aromatic mixtures; diesel, fuels and kerosene) and 5 oxygenated solvents (alcohols; ketones and esters; ethylene glycol; diethyl ether; tetrahydrofuran). OR and 95% CIs, adjusted for smoking, alcohol drinking, age and geographical area, were estimated with logistic models.Results Elevated ORs were observed among women ever exposed to perchloroethylene (OR=2.97, 95% CI 1.05 to 8.45) and trichloroethylene (OR=2.15, 95% CI 1.21 to 3.81). These ORs increased with exposure duration (OR=3.75, 95% CI 0.64 to 21.9 and OR=4.44, 95% CI 1.56 to 12.6 for 10 years or more, respectively). No significantly increased risk of HNSCC was found for occupational exposure to the other chlorinated, petroleum or oxygenated solvents.Conclusions These findings suggest that exposure to perchloroethylene or trichloroethylene may increase the risk of HNSCC in women. In our study, there is no clear evidence that the other studied solvents are risk factors for HNSCC.
ISSN: 2044-6055

Droits : http://creativecommons.org/licenses/by-nc/
hal-01438872
http://hal.upmc.fr/hal-01438872
http://hal.upmc.fr/hal-01438872/document
http://hal.upmc.fr/hal-01438872/file/e012833.full.pdf
DOI : 10.1136/bmjopen-2016-012833

Éditeur(s) : HAL CCSD Institute of Electrical and Electronics Engineers (IEEE)/Optical Society of America(OSA)
Résumé : International audience
Nanometric displacement measurements by Extrinsic Fiber Fabry-Perot interferometers (EFPI) is extremely susceptible to external environmental changes. Temperature, in particular, has a remarkable influence on the optical power and wavelength of the laser diode in use, in addition to the thermal expansion of the mechanical structure. In this paper we propose an optimization of the EFPI sensor in order to use it for very long-term (more than one year) and for high-precision displacement measurements. For this purpose, a real time and adaptive estimation procedure based on a homodyne technique and a Kalman filter is established. During a sinusoidal laser diode current modulation, the Kalman filter provides a correction of the amplitude drift caused by the resultant optical power modulation and external perturbations. Besides, stationary temperature transfer operators are estimated via experimental measurements to reduce the additive thermal noise induced in the optical phase and mechanical components.
ISSN: 0733-8724

hal-00876339
https://hal.archives-ouvertes.fr/hal-00876339
DOI : 10.1109/JLT.2012.2194476

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
Fish mucus has important biological and ecologicalroles such as defense against fish pathogens andchemical mediation among several species. A non-targetedliquid chromatography–mass spectrometry metabolomicapproach was developed to study gill mucus of eight butterflyfishspecies in Moorea (French Polynesia), and theinfluence of several fish traits (geographic site and reefhabitat, species taxonomy, phylogeny, diet and parasitismlevels) on the metabolic variability was investigated. Abiphasic extraction yielding two fractions (polar and apolar)was used. Fish diet (obligate corallivorous, facultativecorallivorous or omnivorous) arose as the main driver ofthe metabolic differences in the gill mucus in both fractions,accounting for 23% of the observed metabolic variabilityin the apolar fraction and 13% in the polar fraction.A partial least squares discriminant analysis allowed us toidentify the metabolites (variable important in projection,VIP) driving the differences between fish with differentdiets (obligate corallivores, facultative corallivores andomnivorous). Using accurate mass data and fragmentationdata, we identified some of these VIP as glycerophosphocholines,ceramides and fatty acids. Level of monogeneangill parasites was the second most important factor shapingthe gill mucus metabolome, and it explained 10% of themetabolic variability in the polar fraction and 5% in theapolar fraction. A multiple regression tree revealed that themetabolic variability due to parasitism in the polar fractionwas mainly due to differences between non-parasitized andparasitized fish. Phylogeny and butterflyfish species werefactors contributing significantly to the metabolic variabilityof the apolar fraction (10 and 3%, respectively) buthad a less pronounced effect in the polar fraction. Finally,geographic site and reef habitat of butterflyfish species didnot influence the gill mucus metabolome of butterflyfishes.
ISSN: 0722-4028

hal-01563312
https://hal-univ-perp.archives-ouvertes.fr/hal-01563312
DOI : 10.1007/s00338-017-1554-0

Éditeur(s) : HAL CCSD
Résumé : International audience
Continental erosion and weathering destroy parts of the stratigraphic record. Analyses of the sedimentary filling of paleokarsts help completing the geological record of regions that have been submitted to post-depositional, long-term, continental evolution. Jurassic carbonate platform of Languedoc (South of France) has undergone several karstification phases from Cretaceous to Neogene. Later incision of canyons through the carbonate massifs allows to observe paleokarsts over 400m depth, within the massifs. Paleokarsts are partly filled with sediments. Some have yielded marine bioclasts (echinoderms, radiolars), foraminifera and nannofossils; others are composed of polygenic detrital sediments, including sources from the upstream Paleozoic basement (Cevennes). The age of the filling of successive paleokarsts can be constrained by structural relationships and by biostratigraphy. These findings suggests 1) the marine elements of the karstic filling relate to a Late Cretaceous to Early Paleocene interval, while 2) the Paleozoic basement-sourced-sediments were trapped in the karst during Miocene to Present. Karstic sediment containing Early Paleocene foraminifera and nannofossils are found in paleokarsts cavities distributed across the entire thickness of the carbonate massif (≥350m). This requires base-level lowering and associated karstification, followed by base-level rise and karst filling of at least 350 m amplitude, respectively. The time interval corresponding to the occurrence of foraminifera and nannofossils in karsts covers 10 Myrs ; surprisingly, no equivalent marine sediments are preserved on the surface. In addition, analyses of the different forams species suggests several (up to 3) distinct karstification and marine filling cycles. Finally, sedimentological facies analysis of the karst filling reveals the following succession of processes: low energy settling of mudstone, high energy reworking, transport and deposition of silts and sandstones within the karst system. Integration of geological, paleontological and sedimentological data, leads to a polyphase scenario in response to repeated base-level variations, more than 350m amplitude. Such an amplitude excludes eustacy, and the improbable repeated sequence of uplift and subsidence rules out tectonics, as driving forces for base-level change, respectively. We propose that the high-amplitude base-level changes results from a succession of desiccation-flooding events of an endorheic, silled, basin during Early Paleogene. The later detrital assemblage sourced in the Cevennes occurs on perched paleosurfaces and in karst cavities across the whole 350m-deep canyon walls. When found on paleosurfaces, they correspond to the south-flowing Early Miocene fluvial drainage, and can be correlated downstream with the marine, well dated, Early Miocene, sediments. When found within the karst cavities, they correspond to successive base-level surfaces connected to the progressive incision of the canyon. This canyon incision is coeval with a Late Miocene uplift of the hinterland.
24th International Karstological School "Classical karst" : Paleokarst
Postojna, Slovenia

hal-01306683
https://hal-brgm.archives-ouvertes.fr/hal-01306683
https://hal-brgm.archives-ouvertes.fr/hal-01306683/document
https://hal-brgm.archives-ouvertes.fr/hal-01306683/file/Abstract_IKS.pdf

Éditeur(s) : HAL CCSD Nature Publishing Group
Résumé : International audience
The etiology of congenital heart defect (CHD) combines environmental and genetic factors. So far, there were studies reporting on the screening of a single gene on unselected CHD or on familial cases selected for specific CHD types. Our goal was to systematically screen a proband of familial cases of CHD on a set of genetic tests to evaluate the prevalence of disease-causing variant identification. A systematic screening of GATA4, NKX2-5, ZIC3 and Multiplex ligation-dependent probe amplification (MLPA) P311 Kit was setup on the proband of 154 families with at least two cases of non-syndromic CHD. Additionally, ELN screening was performed on families with supravalvular arterial stenosis. Twenty-two variants were found, but segregation analysis confirmed unambiguously the causality of 16 variants: GATA4 (1 x), NKX2-5 (6 x), ZIC3 (3 x), MLPA (2 x) and ELN (4 x). Therefore, this approach was able to identify the causal variant in 10.4% of familial CHD cases. This study demonstrated the existence of a de novo variant even in familial CHD cases and the impact of CHD variants on adult cardiac condition even in the absence of CHD. This study showed that the systematic screening of genetic factors is useful in familial CHD cases with up to 10.4% elucidated cases. When successful, it drastically improved genetic counseling by discovering unaffected variant carriers who are at risk of transmitting their variant and are also exposed to develop cardiac complications during adulthood thus prompting long-term cardiac follow-up. This study provides an important baseline at dawning of the next-generation sequencing era.
ISSN: 1018-4813

hal-01404211
https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01404211
DOI : 10.1038/ejhg.2015.105
PUBMED : 26014430

Éditeur(s) : HAL CCSD Société géologique de France
Résumé : New radiolarian assemblages of Late Jurassic age were extracted from seven chert localities of the basement comp ex of La Desirade Island (Guadeloupe), the oldest geological unit of the Lesser Antilles arc and the eastern Caribbean region. These fauna range in age from Kimmeridgian or early Tithonian to early or early late Tithonian, showing that La Desirade cherts are not all coeval, contrary to what was established by previous studies. Furthermore, the close spatial association of cherts and volcanic elements composed of basaltic flows and volcaniclastics suggests a mixed setting of hydrothermal siliceous deposits and biogenous sedimentation consistent with an arc-related oceanic setting rather than an ophiolite-type oceanic crust. As the Youngest age is obtained to the northwest of the basement complex where as older data are found to the southeast, it also Suggests that La Desirade basement complex may have undergone some structural stacking consistent with an accretion-type geodynamic getting. Our biochronological data provide a preliminury try tectonic model of an eastward subduction zone for Lesser Antilles arc basement emplacement during the Mesozois.
EISSN: 1777-5817

hal-00445252
https://hal.archives-ouvertes.fr/hal-00445252
DOI : 10.2113/gssgfbull.180.5.399

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
ISSN: 0264-3707

hal-00680683
https://hal-brgm.archives-ouvertes.fr/hal-00680683
DOI : 10.1016/j.jog.2011.11.010