Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
ISSN: 0169-1368

hal-00329701
https://hal.archives-ouvertes.fr/hal-00329701
DOI : 10.1016/j.oregeorev.2008.03.003

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The aim of this study is to assess the availability and quality of data from the International GNSS Service (IGS) Global Positioning System (GPS) network in Africa, especially for retrieving zenith tropospheric delay (ZTD), from which precipitable water vapour (PWV) can be derived, in view of application to the African Monsoon Multidisciplinary Analysis (AMMA) project. Three major error sources for the GPS data analysis evaluating PWV in Africa are the accuracy of the satellite orbits, the correction for the radio delay induced by the ionosphere and the vertical site displacements due to ocean loading. The first part of this study examines these error sources and the validity of GPS data for meteorological applications in Africa in dedicated analyses spanning the year 2001. These analyses were performed using the IGS precise orbits. Weak degradation of baseline precision with increasing baseline lengths suggests that the average orbital error is not limiting the GPS analysis in Africa. The impact of the ionosphere has been evaluated during a maximum of solar activity in 2001. The loss of L2 data has actually been observed. It amounts to 2% on average for 2001, with maxima of 8% during magnetic storm events. A slight decrease in formal accuracy of ZTD seems to be related to the loss of L2 data at the end of the day. This indicates that scintillation effects are present in the GPS observations but however are not a major limitation. The impact of ocean loading is found to be significant on ZTD estimates (up to ±2 mm in equivalent PWV). The use of a proper ocean loading model eliminates this effect. The second aspect of this study concerns the IGS analysis quality for the African stations. The accuracy has been assessed through position dispersion between individual solutions and the most recent version of the IGS combined solution IGb00, and residuals from the transformation of the IGS combined solution into the International Terrestrial Reference Frame 2005. The positioning performance of the IGS analysis is consistent with an accuracy in ZTD of ±6 mm (±1 mm in PWV), as requested for meteorological applications such as planned in AMMA.
ISSN: 1364-6826

insu-00347961
https://hal-insu.archives-ouvertes.fr/insu-00347961
DOI : 10.1016/j.jastp.2007.04.008

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Deformation of the continental lithosphere is traditionally modeled assuming that heat production in the subcontinental lithospheric mantle is negligible. Although this may be appropriate for highly depleted Archean lithosphere, studies of mantle xenoliths and lithospheric-derived mafic rocks suggest that heat productions of up to 0.4 ;μW/m3 may be attained in the mantle of Phanerozoic and Neoproterozoic regions due to modal metasomatism. To investigate the effect of a local enrichment in heat-producing elements within the lithospheric mantle on the continental deformation, we performed a series of 2D thermo-mechanical models simulating the deformation of a lithospheric plate 1000 km long, which contains in its central part a 200 km wide and 20 km-thick mantle layer with a heat production of 0.05;–0.25 ;μW/m3 between 40 and 80 km depth, leading to a local enhancement of the surface heat flow by 1;–5 mW/m2. Compression models show that a 20 km-thick layer with a heat production as low as 0.05 ;μW/m3 within the shallow lithospheric mantle leads to strain localization in both the enriched mantle and the overlying crust. Strain localization depends exponentially on the temperature increase in the lithosphere section, which is controlled by the volume of metasomatized mantle and the intensity of the metasomatic enrichment in heat-producing elements. A heat production of 0.25 μW/m3 between 60 and 80 km depth results, for instance, in strains within and above the metasomatized mantle 5 times higher than in the surrounding lithosphere. Strain localization also depends on the location of the heat-producing domain and on the plate rheological structure; deeper heat-producing domains and weaker plates leading to stronger localization. These results provide an explanation for strain localization in intraplate environments, leading to the formation of orogenic belts situated hundreds to thousands of kilometers away from known plate boundaries, as observed in the Neoproterozoic belts of Gondwana and in the present-day deformation of the Asian plate.
ISSN: 0012-821X

hal-00411386
https://hal.archives-ouvertes.fr/hal-00411386
DOI : 10.1016/j.epsl.2008.07.040

Éditeur(s) : HAL CCSD Elsevier
Résumé : We studied the evolution of the microstructure of ice-Ih during static recrystallization by stepwise annealing experiments. We alternated thermal annealing and electron backscatter diffraction (EBSD) analyses on polycrystalline columnar ice pre-deformed in uniaxial compression at temperature of −7 °C to macroscopic strains of 3.0–5.2. Annealing experiments were carried out at −5 °C and −2 °C up to a maximum of 3.25 days, typically in 5–6 steps. EBSD crystal orientation maps obtained after each annealing step permit the description of microstructural changes. Decrease in average intragranular misorientation at the sample scale and modification of the misorientation across subgrain boundaries provide evidence for recovery from the earliest stages of annealing. This initial evolution is similar for all studied samples irrespective of their initial strain or annealing temperature. After an incubation period ≥1.5 h, recovery is accompanied by recrystallization (nucleation and grain boundary migration). Grain growth proceeds at the expense of domains with high intragranular misorientations, consuming first the most misorientated parts of primary grains. Grain growth kinetics fits the parabolic growth law with grain growth exponents in the range of 2.4–4.0. Deformation-induced tilt boundaries and kink bands may slow down grain boundary migration. They are stable features during early stages of static recrystallization, only erased by normal growth, which starts after >24 h of annealing.
ISSN: 0191-8141

hal-01685644
https://hal.archives-ouvertes.fr/hal-01685644
DOI : 10.1016/j.jsg.2017.05.001

Éditeur(s) : HAL CCSD American Medical Association (AMA)
Résumé : International audience
IMPORTANCE Although frequently used in treating intensive care unit (ICU) patients with sepsis, empirical antifungal therapy, initiated for suspected fungal infection, has not been shown to improve outcome. OBJECTIVE To determine whether empirical micafungin reduces invasive fungal infection (IFI)-free survival at day 28. DESIGN, SETTING, AND PARTICIPANTS Multicenter double-blind placebo-controlled study of 260 nonneutropenic, nontransplanted, critically ill patients with ICU-acquired sepsis, multiple Candida colonization, multiple organ failure, exposed to broad-spectrum antibacterial agents, and enrolled between July 2012 and February 2015 in 19 French ICUs. INTERVENTIONS Empirical treatment with micafungin (100mg, once daily, for 14 days) (n = 131) vs placebo (n = 129). MAIN OUTCOMES AND MEASURES The primary end pointwas survival without proven IFI 28 days after randomization. Key secondary end points included new proven fungal infections, survival at day 28 and day 90, organ failure, serum (1-3)-beta-D-glucan level evolution, and incidence of ventilator-associated bacterial pneumonia. RESULTS Among 260 patients (mean age 63 years; 91 [35%] women), 251 (128, micafungin group; 123, placebo group) were included in the modified intent-to-treat analysis. Median values were 8 for Sequential Organ Failure Assessment (SOFA) score, 3 for number of Candida-colonized sites, and 99 pg/mL for level of (1-3)-beta-D-glucan. On day 28, there were 82 (68%) patients in the micafungin group vs 79 (60.2%) in the placebo group who were alive and IFI free (hazard ratio [HR], 1.35 [95% CI, 0.87-2.08]). Results were similar among patients with a (1-3)-beta-D-glucan level of greater than 80 pg/mL (n = 175; HR, 1.41 [95% CI, 0.85-2.33]). Day-28 IFI-free survival in patients with a high SOFA score (> 8) was not significantly different when compared between the micafungin vs placebo groups (HR, 1.69 [95% CI, 0.96-2.94]). Use of empirical micafungin decreased the rate of new invasive fungal infection in 4 of 128 patients (3%) in the micafungin group vs placebo (15/123 patients [12%]) (P =.008). CONCLUSIONS AND RELEVANCE Among nonneutropenic critically ill patients with ICU-acquired sepsis, Candida species colonization at multiple sites, and multiple organ failure, empirical treatment with micafungin, compared with placebo, did not increase fungal infection-free survival at day 28.
ISSN: 0098-7484

hal-01405822
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01405822
DOI : 10.1001/jama.2016.14655
PUBMED : 27706483

Éditeur(s) : HAL CCSD American Geophysical Union (AGU)
Résumé : International audience
The Calabro-Peloritan belt constitutes the eastward termination of the southern segment of the Alpine Mediterranean belt. This orogenic system was built up during the convergence between the Eurasian and the African plates, roughly directed North-South since the Upper Cretaceous. It was subsequently fragmented during the opening of the Western Mediterranean basins since Oligocene times. The curved shape of the Calabro-Peloritan belt was acquired during the opening of the Tyrrhenian basin since Tortonian. The origin, kinematics and significance of the Calabro-Peloritan tectonic pile are still debated. Our data in the Aspromonte Massif of Southern Calabria reveal an Alpine history marked by two main superimposed kinematic regimes. (i) A first phase corresponds to the piling up of basement nappes with a top-to-the-SE vergence, i.e in a direction orthogonal to the belt trend and towards the Adriatic foreland. This external vergence is similar to what is observed in both Northeastern Sicily and Northern Calabria. In Sicily, the age of nappe piling is Alpine, as evidenced by pinched slices of Mesozoïc sediments. In the Aspromonte Massif, thrusting age is less constrained. Our data suggest remnants of late Hercynian structuration before the Alpine stacking. (ii) A second phase corresponds to the thinning of the continental crust, dated at around 30 Ma by both geochronological and stratigraphical data. This extension is mainly localized on two low-angle detachment contacts, with top-to-the-NE displacement. The lower one corresponds to the reworking of the former main nappe contact. The upper one is a large detachment fault cutting across the pile from upper sedimentary levels down to metamorphic basement. Extension of similar Alpine age and similar internal vergence has been already recognized in other parts of the Calabro-Peloritan Arc: in the basement nappes of Northeastern Sicily and in the ophiolitic units of Northern Calabria. Coming back to the original geometry and position of the Calabro-Peloritan belt, before its bending and the opening of the Liguro-Provençal and Tyrrhenian basins, we evidence a homogeneous Oligocene NE-SW extension all along the Calabro-Peloritan segment of the Alpine Mediterranean belt. This tectonometamorphic history is best explained within the framework of the continuous Tertiary westward dipping subduction of the Tethyan oceanic domain below the European active margin and the progressive eastward retreat of the Apennine trench since Oligocene times.
ISSN: 0278-7407

hal-00283182
https://hal.archives-ouvertes.fr/hal-00283182
https://hal.archives-ouvertes.fr/hal-00283182/document
https://hal.archives-ouvertes.fr/hal-00283182/file/Heymes_et_al_2008.pdf
DOI : 10.1029/2007TC002157

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
In this paper we investigate finite-frequency effects in crustal tomography. We developed an inversion procedure based on an exact numerical computation of the sensitivity kernels. In this approach we compute the 3D travel-time sensitivity kernels by using (1) graph theory and an additional bending to estimate accurately both rays and travel-times between source/receiver and diffraction points and (2) paraxial ray theory to estimate the amplitude along theses rays. We invert both the velocity and the hypocentre parameters, using these so-called banana-doughnut kernels and the LSQR iterative solver. We compare the ray-theoretical and the finite-frequency tomography to image the intermediate structures beneath the Gulf of Corinth (Greece), which has long been recognized as the most active continental rifting zone in the Mediterranean region. Our dataset consists of 451 local events with 9233 P- firstarrival times recorded in the western part of the Gulf (Aigion area) in the framework of the 3F-Corinth European project. Previous tomographic images showed a complex velocity crustal model and a low-dip surface that may accommodate the deformation. Accurate velocity models will help to better constrain the rifting process, which is still a subject of debate. The main results of this study show that finite-frequency tomography improves crustal tomographic images by providing better resolved images of the 3D complicated velocity structure. Because the kernels spread the information over a volume, finite-frequency tomography results in a sharpening of layer boundaries as we observed for the shallower part of the crust (down to 5 km depth) beneath the Gulf of Corinth.
ISSN: 0016-8025

insu-00354702
https://hal-insu.archives-ouvertes.fr/insu-00354702
DOI : 10.1111/j.1365-2478.2007.00683.x

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
Background: Heterogeneous patterns of malaria transmission are thought to be driven by factors including host genetics, distance to mosquito breeding sites, housing construction, and socio-behavioural characteristics. Evaluation of local transmission epidemiology to characterize malaria risk is essential for planning malaria control and elimination programmes. The use of geographical information systems (GIS) techniques has been a major asset to this approach. To assess time and space distribution of malaria disease in Bandiagara, Mali, within a transmission season, data were used from an ongoing malaria incidence study that enrolled 300 participants aged under six years old ". Methods: Children's households were georeferenced using a handheld global position system. Clinical malaria was defined as a positive blood slide for Plasmodium falciparum asexual stages associated with at least one of the following signs: headache, body aches, fever, chills and weakness. Daily rainfall was measured at the local weather station. Landscape features of Bandiagara were obtained from satellite images and field survey. QGIS™ software was used to map malaria cases, affected and non-affected children, and the number of malaria episodes per child in each block of Bandiagara. Clusters of high or low risk were identified under SaTScan W software according to a Bernoulli model. Results: From June 2009 to May 2010, 296 clinical malaria cases were recorded. Though clearly temporally related to the rains, Plasmodium falciparum occurrence persisted late in the dry season. Two " hot spots " of malaria transmission also found, notably along the Yamé River, characterized by higher than expected numbers of malaria cases, and high numbers of clinical episodes per child. Conversely, the northeastern sector of the town had fewer cases despite its proximity to a large body of standing water which was mosquito habitat. Conclusion: These results confirm the existence of a marked spatial heterogeneity of malaria transmission in Bandiagara, providing support for implementation of targeted interventions. Background Malaria is one of the leading causes of morbidity and mortality in the world, with an estimated 3.3 billion people at risk of malaria [1]. The incidence of malaria worldwide is estimated to be 216 million cases per year, with 81% of these cases occurring in sub-Saharan Africa. Malaria kills approximately 655,000 people per year; 91% of deaths occur in sub-Saharan Africa [1], mostly in children under five years of age. In Mali, West Africa, malaria represents 36.5% of consultation motives in health center, it is a leading cause of morbidity and mortality children of less than five years of age and the first reason of anaemia in pregnant women [2]. Malaria transmission is seasonal. Malaria parasite transmission and clinical disease are characterized by important microgeographic variation, often between adjacent villages, households or families [3-8]. This local heterogeneity is driven by a variety of factors including human genetics [9,10], distance to potential breeding sites [11,12], housing construction
ISSN: 1475-2875

hal-01307672
https://hal-amu.archives-ouvertes.fr/hal-01307672
https://hal-amu.archives-ouvertes.fr/hal-01307672/document
https://hal-amu.archives-ouvertes.fr/hal-01307672/file/1475-2875-12-82.pdf
DOI : 10.1186/1476-072X-2-5

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
In ophiolites and in present-day oceanic crust formed at fast spreading ridges, oceanic plagiogranites are commonly observed at, or close to the base of the sheeted dike complex. They can be produced either by differentiation of mafic melts, or by hydrous partial melting of the hydrothermally altered sheeted dikes. In addition, the hydrothermally altered base of the sheeted dike complex, which is often infiltrated by plagiogranitic veins, is usually recrystallized into granoblastic dikes that are commonly interpreted as a result of prograde granulitic metamorphism. To test the anatectic origin of oceanic plagiogranites, we performed melting experiments on a natural hydrothermally altered dike, under conditions that match those prevailing at the base of the sheeted dike complex. All generated melts are water saturated, transitional between tholeiitic and calc-alkaline, and match the compositions of oceanic plagiogranites observed close to the base of the sheeted dike complex. Newly crystallized clinopyroxene and plagioclase have compositions that are characteristic of the same minerals in granoblastic dikes. Published silicic melt compositions obtained in classical MORB fractionation experiments also broadly match the compositions of oceanic plagiogranites; however, the compositions of the coexisting experimental minerals significantly deviate from those of the granoblastic dikes. Our results demonstrate that hydrous partial melting is a likely common process in the root zone of the sheeted dike complex, starting at temperatures exceeding 850A degrees C. The newly formed melt can either crystallize to form oceanic plagiogranites or may be recycled within the melt lens resulting in hybridized and contaminated MORB melts. It represents the main MORB crustal contamination process. The residue after the partial melting event is represented by the granoblastic dikes. Our results support a model with a dynamic melt lens that has the potential to trigger hydrous partial melting reactions in the previously hydrothermally altered sheeted dikes. A new thermometer using the Al content of clinopyroxene is also elaborated.
ISSN: 0010-7999

hal-00534058
https://hal.archives-ouvertes.fr/hal-00534058
DOI : 10.1007/s00410-010-0502-6

Éditeur(s) : HAL CCSD Météo et Climat
Résumé : International audience
D'initiative française, le projet international HyMeX a pour objectif d'améliorer la compréhension du cycle de l'eau en Méditerranée, de sa variabilité, de l'échelle de l'événement météorologique aux échelles saisonnières et interannuelles, et de ses caractéristiques sur une décennie, dans un contexte de changement global. Le projet est motivé par le rôle déterminant des processus de mésoéchelle, couplés entre l'atmosphère, la mer et la terre, sur la variabilité du système climatique et sur le déclenchement d'événements hydrométéorologiques extrêmes (précipitations et inondations, vents forts et convection océanique, canicules et sécheresses). Le projet vise enfin à évaluer les conséquences de ces événements extrêmes sur la vulnérabilité sociale et économique de cette région et sa capacité d'adaptation.
ISSN: 0026-1181

hal-00828758
https://hal.archives-ouvertes.fr/hal-00828758
https://hal.archives-ouvertes.fr/hal-00828758/document
https://hal.archives-ouvertes.fr/hal-00828758/file/meteo_2013_80_23%20%281%29.pdf
DOI : 10.4267/2042/48792

Éditeur(s) : HAL CCSD
Résumé : International audience
FSPM07 - 5th International Workshop on Functional-Structural Plant Models
Napier, New Zealand

hal-00847590
https://hal.inria.fr/hal-00847590

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Porous thin films considered for applications like separation, sensing and microelectronic have to sustain mechanical stresses during their integration process or in working conditions. Thanks to recent progress in processing methods, it is now possible to precisely control the porosity and combine ordered mesopores with randomly-distributed macropores to achieve hierarchically porous materials. The mechanical properties of thin films containing different types of porosity (ordered meso, random macro and hierarchical) have been investigated by means of nanoindentation. In particular a method recently proposed by Li and Vlassak (H. Li, J.J. Vlassak, Journal of Materials Research 24 (2009) 1114-1126) is applied to account for the substrate effect. Residual indent impressions were imaged by Atomic Force Microscopy (AFM) to provide some insights in the mechanical behavior of the films. In addition, experimental indentation moduli are compared to theoretical predictions obtained via Finite Element (FE) analysis. The different porous structures have been modeled by FE to obtain the effective elastic properties from which the indentation modulus can be inferred. Finally, the experimental-model differences are discussed. © 2010 Elsevier Inc. All rights reserved.
ISSN: 1387-1811

hal-01683194
https://hal.univ-antilles.fr/hal-01683194
DOI : 10.1016/j.micromeso.2010.09.004

Éditeur(s) : HAL CCSD
Résumé : International audience
Cumulative human impacts have led to the degradation of marine ecosystems and thedecline of biodiversity in the European and contiguous seas. Effective conservationmeasures are urgently needed to reverse these trends. Conservation must entail societalchoices, underpinned by human values and worldviews that differ between the countriesbordering these seas. Social, economic and political heterogeneity adds to the challenge ofbalancing conservation with sustainable use of the seas. Comprehensive macro-regionalcoordination is needed to ensure effective conservation of marine ecosystems andbiodiversity of this region. Under the European Union Horizon 2020 framework programme,the MarCons COST action aims to promote collaborative research to support marinemanagement, conservation planning and policy development. This will be achieved bydeveloping novel methods and tools to close knowledge gaps and advance marineconservation science. This action will provide support for the development of macro-regional and national policies through six key actions: to develop tools to analysecumulative human impacts; to identify critical scientific and technical gaps in conservationefforts; to improve the resilience of the marine environment to global change and biologicalinvasions; to develop frameworks for integrated conservation planning across terrestrial,freshwater, and marine environments; to coordinate marine conservation policy acrossnational boundaries; and to identify effective governance approaches for marine protectedarea management. Achieving the objectives of these actions will facilitate the integration ofmarine conservation policy into macro-regional maritime spatial planning agendas for theEuropean and contiguous seas, thereby offsetting the loss of biodiversity and ecosystemservices in this region.
Research Ideas and Outcomes

hal-01474085
https://hal-univ-perp.archives-ouvertes.fr/hal-01474085
https://hal-univ-perp.archives-ouvertes.fr/hal-01474085/document
https://hal-univ-perp.archives-ouvertes.fr/hal-01474085/file/RIO_article_11884.pdf
DOI : 10.3897/rio.3.e11884

Éditeur(s) : HAL CCSD Société géologique de France
Résumé : National audience
Late Triassic submarine alkali basalts and hawaiites were collected from two superimposed tectonic slices belonging to the Kara Dere – Sayrun unit of the Middle Antalya nappes, southwestern Turkey. New determinations on conodont faunas allow to date this sequence to the Lower Carnian (Julian). The volcanic rocks show rather homogeneous compositions, with high TiO2 and relatively low MgO and Ni contents which suggest olivine fractionation. Their primitive mantle-normalised multi-elements plots show Nb and Ta enrichments relative to La, Pb negative anomalies and heavy rare earth element and Y depletions typical of intraplate ocean island basalts. These characteristics are consistent with the major and trace element compositions of their primary clinopyroxene phenocrysts, which do not show any feature ascribable to crustal contamination. The studied lavas display a restricted range of {varepsilon}Nd (+4.6 to +5.2) which falls within the range of ocean island basalts. Their initial (143Nd/144Nd)i ratios are too low to be explained by a simple mixing line between depleted MORB mantle (DMM) and HIMU components. Their Pb and Nd isotopic compositions plot along a mixing line between HIMU component and an enriched mantle, the composition of which could be the result of the addition of about 5 to 8% of an EM2 component (recycled marine sediments) to DMM. The lack of evidence for any continental crustal component in their genesis could be consistent with their emplacement in an intra-oceanic setting.
EISSN: 1777-5817

insu-00338829
https://hal-insu.archives-ouvertes.fr/insu-00338829
DOI : 10.2113/gssgfbull.179.4.397

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
This work describes the history of late Pleistocene glaciations in the central Sayan-Tuva Upland (southern Siberia). Geological and geomorphological analysis as well as 10Be surface-exposure dating revealed the glacier fluctuations in this continental area. The available published data show that the glaciers were formed in the MIS 6 and probably survived in the MIS 5. Data are also available concerning glacial advances in different periods of MIS 4, MIS 3 and MIS 2. ELAs were 2030-2230 m. Two distinct 10Be exposure ages groups are highlighted reflecting the time of formation of glacial deposits in the MIS 2 associated to the Big Sayan Ridge outlet glaciers. The Sentsa - Sailag group (terminal moraine) has a mean exposure age of 16.44 ± 0.38 ka. The Jombolok (terminal moraine) - Jombolok (outwash plain) group has a mean exposure age of 22.80 ± 0.56 ka. The last glaciation that occurred at MIS 2 is characterized by the absence of ice cap on the Azas volcanic Plateau and of ice field in the Todza Basin. The thickness of the valley glacier was 300-400 m. At MIS 2, the terminal moraines were ∼1300-1400 m a.s.l. in the Tissa, Sentsa, Jombolok and Sailag river valleys.
ISSN: 0277-3791

hal-00758082
https://hal.archives-ouvertes.fr/hal-00758082
DOI : 10.1016/j.quascirev.2012.06.005

Éditeur(s) : HAL CCSD
Résumé : International audience
OBJECTIVE: To assess sperm production and aneuploidy in Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) before and after treatments. DESIGN: Multicenter, prospective, longitudinal study of lymphoma patients analyzed before treatment and after 3, 6, 12, and 24 months. SETTING: University hospitals. PATIENT(S): Forty-five HL and 13 NHL patients were investigated before and after treatment. Treatment regimens were classified in two groups: ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine) with or without (+/-) radiotherapy, and CHOP (doxorubicin, cyclophosphamide, vincristine, prednisone)/MOPP-ABV (mechlorethamine, oncovin, procarbazine, prednisone-doxorubicin, bleomycin, vinblastine). A control group of 29 healthy men was also studied. INTERVENTION(S): Semen analyses and aneuploidy study by FISH were performed at each time point. MAIN OUTCOME MEASURE(S): Comparison of mean sperm characteristics and percentage of sperm aneuploidy rates before and after treatment. RESULT(S): Before treatment, HL and NHL men had altered semen characteristics and higher sperm aneuploidy rates (median 0.76 [interquartile range 0.56-0.64]) than the control group (0.54 [0.46-0.74]). After treatment, sperm production was significantly lowered 3 and 6 months after ABVD +/- radiotherapy or CHOP/MOPP-ABV. After ABVD +/- radiotherapy, the aneuploidy rate increased significantly only at 3 months, and values obtained 1 or 2 years later were lower than pretreatment values. In contrast, in the CHOP/MOPP-ABV treatment group, semen characteristics and aneuploidy rate did not return to normal levels until 2 years after treatment. CONCLUSION(S): Lymphoma itself has consequences on sperm aneuploidy frequency before treatment. Moreover, lymphoma treatments have deleterious effects on sperm chromosomes related to treatment type and time since treatment. Patient counseling is essential concerning the transient but significant sperm aneuploidy induced by lymphoma and its treatments.
Fertility and sterility

hal-01477204
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01477204
DOI : 10.1016/j.fertnstert.2016.10.001
PUBMED : 27810161

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The presence of two regional seismic networks in southeastern France provides us high-quality data to investigate upper mantle flow by measuring the splitting of teleseismic shear waves induced by seismic anisotropy. The 10 three-component and broadband stations installed in Corsica, Provence, and western Alps efficiently complete the geographic coverage of anisotropy measurements performed in southern France using temporary experiments deployed on geodynamic targets such as the Pyrenees and the Massif Central. Teleseismic shear waves (mainly SKS and SKKS) are used to determine the splitting parameters: the fast polarization direction and the delay time. Delay times ranging between 1.0 and 1.5 s have been observed at most sites, but some larger delay times, above 2.0 s, have been observed at some stations, such as in northern Alps or Corsica, suggesting the presence of high strain zones in the upper mantle. The azimuths of the fast split shear waves define a simple and smooth pattern, trending homogeneously WNW–ESE in the Nice area and progressively rotating to NW–SE and to NS for stations located further North in the Alps. This pattern is in continuity with the measurements performed in the southern Massif Central and could be related to a large asthenospheric flow induced by the rotation of the Corsica–Sardinia lithospheric block and the retreat of the Apenninic slab. We show that seismic anisotropy nicely maps the route of the slab from the initial rifting phase along the Gulf of Lion (30–22 Ma) to the drifting of the Corsica–Sardinia lithospheric block accompanied by the creation of new oceanic lithosphere in the Liguro–Provençal basin (22–17 Ma). In the external and internal Alps, the pattern of the azimuth of the fast split waves follows the bend of the alpine arc. We propose that the mantle flow beneath this area could be influenced or perhaps controlled by the Alpine deep penetrative structures and that the Alpine lithospheric roots may have deflected part of the horizontal asthenospheric flow around its southernmost tip.
ISSN: 0040-1951

hal-00109313
https://hal.archives-ouvertes.fr/hal-00109313
https://hal.archives-ouvertes.fr/hal-00109313/document
https://hal.archives-ouvertes.fr/hal-00109313/file/barruol_TGRS_Tphy2004_hal.pdf
DOI : 10.1016/j.tecto.2004.08.002

Éditeur(s) : HAL CCSD BRGM
Résumé : National audience
Proceedings 1ère Journée 'Alea Gravitaire'
Orléans, France

hal-00533951
https://hal.archives-ouvertes.fr/hal-00533951

Éditeur(s) : HAL CCSD springer Link
Résumé : International audience
Experimental Astronomy

hal-01094521
https://hal.archives-ouvertes.fr/hal-01094521
BIBCODE : 2014ExA...tmp...41R
DOI : 10.1007/s10686-014-9383-4
ARXIV : 1310.0696

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The eastern part of the Cordillera Occidental of Ecuador comprises thick buoyant oceanic plateaus associated with island-arc tholeiites and subduction-related calc-alkaline series, accreted to the Ecuadorian Continental Margin from Late Cretaceous to Eocene times. One of these plateau sequences, the Guaranda Oceanic Plateau is considered as remnant of the Caribbean–Colombian Oceanic Province (CCOP) accreted to the Ecuadorian Margin in the Maastrichtien. Samples studied in this paper were taken from four cross-sections through two arc-sequences in the northern part of the Cordillera Occidental of Ecuador, dated as (Río Cala) or ascribed to (Macuchi) the Late Cretaceous and one arc-like sequence in the Chogòn-Colonche Cordillera (Las Orquídeas). These three island-arcs can clearly be identified and rest conformably on the CCOP. In all four localities, basalts with abundant large clinopyroxene phenocrysts can be found, mimicking a picritic or ankaramitic facies. This mineralogical particularity, although not uncommon in island arc lavas, hints at a contribution of the CCOP in the genesis of these island arc rocks. The complete petrological and geochemical study of these rocks reveals that some have a primitive island-arc nature (MgO values range from 6 to 11 wt.%). Studied samples display marked Nb, Ta and Ti negative anomalies relative to the adjacent elements in the spidergrams characteristic of subduction-related magmatism. These rocks are LREE-enriched and their clinopyroxenes show a tholeiitic affinity (FeOT–TiO2 enrichment and CaO depletion from core to rim within a single crystal). The four sampled cross-sections through the island-arc sequences display homogeneous initial Nd, and Pb isotope ratios that suggest a unique mantellic source for these rocks resulting from the mixing of three components: an East-Pacific MORB end-member, an enriched pelagic sediment component, and a HIMU component carried by the CCOP. Indeed, the ankaramite and Mg-basalt sequences that form part of the Caribbean-Colombian Oceanic Plateau are radiogenically enriched in 206Pb/204Pb and 207Pb/204Pb and contain a HIMU component similar to that observed in the Gorgona basalts and Galápagos lavas. The subduction zone that generated the Late Cretaceous arcs occurred far from the continental margin, in an oceanic environment. This implies that no terrigenous detrital sediments interacted with the source at this period. Thus, the enriched component can only result from the melting of subducted pelagic sediments. We have thus defined the East-Pacific MORB, enriched (cherts, pelagic sediments) and HIMU components in an attempt to constrain and model the genesis of the studied island-arc magmatism, using a compilation of carefully selected isotopic data from literature according to rock age and paleogeographic location at the time of arc edification. Tripolar mixing models reveal that proportions of 12–15 wt.% of the HIMU component, 7–15 wt.% of the pelagic sediment end-member and 70–75 wt.% of an East-pacific MORB end-member are needed to explain the measured isotope ratios. These surprisingly high proportions of the HIMU/CCOP component could be explained by the young age of the oceanic plateau (5–15 Ma) during the Late Cretaceous arc emplacement. The CCOP, basement of these arc sequences, was probably still hot and easily assimilated at the island-arc lava source.
ISSN: 0895-9811

insu-00353692
https://hal-insu.archives-ouvertes.fr/insu-00353692
DOI : 10.1016/j.jsames.2008.06.003