Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
The Hedgehog (Hh) family of secreted proteins act as morphogens to control embryonic patterning and development in a variety of organ systems. Post-translational covalent attachment of cholesterol and palmitate to Hh proteins are critical for multimerization and long range signaling potency. However, the biological impact of lipid modifications on Hh ligand distribution and signal reception in humans remains unclear. In the present study, we report a unique case of autosomal recessive syndromic 46,XY Disorder of Sex Development (DSD) with testicular dysgenesis and chondrodysplasia resulting from a homozygous G287V missense mutation in the hedgehog acyl-transferase (HHAT) gene. This mutation occurred in the conserved membrane bound O-acyltransferase (MBOAT) domain and experimentally disrupted the ability of HHAT to palmitoylate Hh proteins such as DHH and SHH. Consistent with the patient phenotype, HHAT was found to be expressed in the somatic cells of both XX and XY gonads at the time of sex determination, and Hhat loss of function in mice recapitulates most of the testicular, skeletal, neuronal and growth defects observed in humans. In the developing testis, HHAT is not required for Sertoli cell commitment but plays a role in proper testis cord formation and the differentiation of fetal Leydig cells. Altogether, these results shed new light on the mechanisms of action of Hh proteins. Furthermore, they provide the first clinical evidence of the essential role played by lipid modification of Hh proteins in human testicular organogenesis and embryonic development.
ISSN: 1553-7390

hal-01063929
https://hal.archives-ouvertes.fr/hal-01063929
DOI : 10.1371/journal.pgen.1004340
PUBMED : 24784881

Éditeur(s) : HAL CCSD Université des Antilles
Résumé : International audience
Develop tourism as a tool in the fight against poverty requires first to agree on the meaning of the word poverty and to clarify the political intentions of the project. Reflection on the reduction of poverty through the tourism can be synthesized in three steps: first, the beneficial effects of runoff from tourist revenues in host societies, then the collateral damage resulting from tourism and, finally, to define the conditions necessary to integrate positively tourism project in the host territories.In the end, it is indispensable to develop a proactive policy, because the poorest will not benefit from famous income runoff. Taking into account complex and contradictory impact of international tourism (including inflation, revenue leakage, deconstruction accelerated of local societies), it is necessary to include it in a sustained and coherent territorial project by local communities to identify real benefits.
Concevoir le tourisme comme un outil de lutte contre la pauvreté nécessite en premier lieu de s’entendre sur le sens du mot pauvreté et de clarifier les intentions politiques d’un tel projet. La réflexion sur la réduction de la pauvreté grâce au tourisme peut être synthétisée en trois temps : tout d’abord, les effets bénéfiques du ruissellement des revenus touristiques dans les sociétés d’accueil, ensuite les dommages collatéraux qui résultent du tourisme et, finalement, définir les conditions nécessaires pour intégrer favorablement le projet touristique dans les territoires hôtes. Au final, il apparaît indispensable de développer une politique volontariste, car le fameux ruissellement de revenus ne va pas naturellement profiter aux plus démunis. Compte tenu des impacts complexes et contradictoires du tourisme international (notamment en matière d’inflation, de fuites des revenus, de déstructuration accélérée des sociétés locales), il faut l’inscrire dans un projet d’un territorial cohérent et soutenu par les communautés locales afin de dégager de réels bénéfices.
ISSN: 1779-0980

Droits : http://creativecommons.org/licenses/by-nc/
hal-01368491
https://hal.univ-antilles.fr/hal-01368491
https://hal.univ-antilles.fr/hal-01368491/document
https://hal.univ-antilles.fr/hal-01368491/file/tourisme-et-lutte-contre-la-pauvrete-opportunites-et-defis.pdf
DOI : 10.4000/etudescaribeennes.6601

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Lung diseases are aggravated by exposure to diesel exhaust particles (DEPs) found in air pollution. Macrophages are thought to play a crucial role in lung immune response to these pollutants, even if the mechanisms involved remain incompletely characterized. In the present study, we demonstrated that classically and alternative human macrophages (MΦ) exhibited increased secretion of PDGF-B in response to DEP extract (DEPe). This occurred via aryl hydrocarbon receptor (AhR)-activation because DEPe-induced PDGF-B overexpression was abrogated after AhR expression knock-down by RNA interference, in both M1 and M2 polarizing MΦ. In addition, TCDD and benzo(a)pyrene, two potent AhR ligands, also significantly increased mRNA expression of PDGF-B in M1 MΦ, whereas some weak ligands of AhR did not. We next evaluated the impact of conditioned media (CM) from MΦ culture exposed to DEPe or of recombinant PDGF-B onto lung fibroblast proliferation. The tyrosine kinase inhibitor, AG1295, prevents phosphorylations of PDGF-Rβ, AKT and ERK1/2 and the proliferation of MRC5 fibroblasts induced by recombinant PDGF-B and by CM from M1 polarizing MΦ, strongly suggesting that the PDGF-BB secreted by DEPe-exposed MΦ is sufficient to activate the PDGF-Rβ pathway of human lung fibroblasts. In conclusion, we demonstrated that human MΦ, whatever their polarization status, secrete PDGF-B in response to DEPe and that PDGF-B is a target gene of AhR. Therefore, induction of PDGF-B by DEP may participate in the deleterious effects towards human health triggered by such environmental urban contaminants.
ISSN: 0041-008X

hal-01146840
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01146840
DOI : 10.1016/j.taap.2015.04.007
PUBMED : 25896968

Éditeur(s) : HAL CCSD
Résumé : International audience
BACKGROUND: The aryl hydrocarbon receptor (AhR) has gradually emerged as a regulator of inflammation in the lung and other tissues. AhR may interact with the p65-subunit of the nuclear factor (NF)-κB transcription factors, but reported outcomes of AhR/NF-κB-interactions are conflicting. Some studies suggest that AhR possess pro-inflammatory activities while others suggest that AhR may be anti-inflammatory. The present study explored the impact of AhR and its binding partner AhR nuclear translocator (Arnt) on p65-activation and two differentially regulated chemokines, CXCL8 (IL-8) and CCL5 (RANTES), in human bronchial epithelial cells (BEAS-2B). RESULTS: Cells were exposed to CXCL8- and CCL5-inducing chemicals, 1-nitropyrene (1-NP) and 1-aminopyrene (1-AP) respectively, or the synthetic double-stranded RNA analogue, polyinosinic-polycytidylic acid (Poly I:C) which induced both chemokines. Only CXCL8, and not CCL5, appeared to be p65-dependent. Yet, constitutively active unligated AhR suppressed both CXCL8 and CCL5, as shown by siRNA knock-down and the AhR antagonist α-naphthoflavone. Moreover, AhR suppressed activation of p65 by TNF-α and Poly I:C as assessed by luciferase-assay and p65-phosphorylation at serine 536, without affecting basal p65-activity. In contrast, Arnt suppressed only CXCL8, but did not prevent the p65-activation directly. However, Arnt suppressed expression of the NF-κB-subunit RelB which is under transcriptional regulation by p65. Furthermore, AhR-ligands alone at high concentrations induced a moderate CXCL8-response, without affecting CCL5, but suppressed both CXCL8 and CCL5-responses by Poly I:C. CONCLUSION: AhR and Arnt may differentially and independently regulate chemokine-responses induced by both inhaled pollutants and pulmonary infections. Constitutively active, unligated AhR suppressed the activation of p65, while Arnt may possibly interfere with the action of activated p65. Moreover, ligand-activated AhR suppressed CXCL8 and CCL5 responses by other agents, but AhR ligands alone induced CXCL8 responses when given at sufficiently high concentrations, thus underscoring the duality of AhR in regulation of inflammation. We propose that AhR-signaling may be a weak activator of p65-signaling that suppresses p65-activity induced by strong activators of NF-κB, but that its anti-inflammatory properties also are due to interference with additional pathways.
Cell communication and signaling: CCS

hal-01063555
https://hal.archives-ouvertes.fr/hal-01063555
DOI : 10.1186/s12964-014-0048-8

Éditeur(s) : HAL CCSD National Institute of Environmental Health Sciences
Résumé : International audience
BACKGROUND: Women of reproductive age can be exposed to endocrine-disrupting chemicals (EDCs) at work, and exposure to EDCs in pregnancy may affect fetal growth. OBJECTIVES: We assessed whether maternal occupational exposure to EDCs during pregnancy as classified by application of a job exposure matrix was associated with birth weight, term low birth weight (LBW), length of gestation, and preterm delivery. METHODS: Using individual participant data from 133,957 mother-child pairs in 13 European cohorts spanning births from 1994 through 2011, we linked maternal job titles with exposure to 10 EDC groups as assessed through a job exposure matrix. For each group, we combined the two levels of exposure categories (possible and probable) and compared birth outcomes with the unexposed group (exposure unlikely). We performed meta-analyses of cohort-specific estimates. RESULTS: Eleven percent of pregnant women were classified as exposed to EDCs at work during pregnancy, based on job title. Classification of exposure to one or more EDC group was associated with an increased risk of term LBW [odds ratio (OR) = 1.25; 95% CI: 1.04, 1.49], as were most specific EDC groups; this association was consistent across cohorts. Further, the risk increased with increasing number of EDC groups (OR = 2.11; 95% CI: 1.10, 4.06 for exposure to four or more EDC groups). There were few associations (p < 0.05) with the other outcomes; women holding job titles classified as exposed to bisphenol A or brominated flame retardants were at higher risk for longer length of gestation. CONCLUSION: Results from our large population-based birth cohort design indicate that employment during pregnancy in occupations classified as possibly or probably exposed to EDCs was associated with an increased risk of term LBW.
ISSN: 0091-6765

hal-01405823
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01405823
DOI : 10.1289/EHP208
PUBMED : 27152464

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Objective: The first aim of this study was to evaluate the antimicrobial resistance of Enterobacteriaceae in different water environments of Guadeloupe and especially those impacted by waste water treatment plants (WWTP) effluents. The second objective was to characterize the genetic basis for antibiotic resistance of extended-spectrum beta-lactamase (ESBL) and AmpC beta-lactamase producing Enterobacteriaceae isolates (ESBLE and AmpCE).Methods: We have collected 70 surface waters (river and sea samples) impacted or not by WWTP and 18 waste waters from 2 WWTPs in 2012 and 2013. We i) determined the total and resistant bacterial counts and ii) tested isolated Enterobacteriaceae for their antimicrobial susceptibility. We also studied the genetic basis for antibiotic resistance of ESBLE and AmpCE, and the genetic background of Escherichia coli.Results: In rivers, contamination with Escherichia coli and antibiotic resistant coliforms (ARC) increased from the source to the mouth. Highest levels of river contamination with E. coli (9.26 x 105 MPN/100mL) and ARC (2.26 x 108 CFU/mL) were observed in surface water sampled near the discharge. A total of 246 Enterobacteriaceae strains resistant to antibiotics were isolated, mostly from waste waters and from river water collected near the discharge. Among these strains, 33 were Extended Spectrum Beta Lactamase (ESBLE) and 8 E. coli were AmpC beta-lactamase producers. All the ESBLE were isolated from waste waters or from river water collected near the discharge. The blaCTX-M gene was present in 29 of the 33 ESBLE strains, with 24 belonging to group 1. Numerous strains (68.7%) showed more than one acquired antibiotic resistance mechanism. E. coli strains belonged to different phylogenetic groups; among the B2 group, most strains belonged to the ST131 clone.Conclusion: Our results demonstrated that many human activities can supply antibiotic-resistant bacteria in surface water. Nevertheless, WWTPs were the most important supplier of ESBLE in water environment of Guadeloupe.
ISSN: 1932-6203

Droits : http://creativecommons.org/licenses/by/
hal-01485327
http://hal.upmc.fr/hal-01485327
http://hal.upmc.fr/hal-01485327/document
http://hal.upmc.fr/hal-01485327/file/journal.pone.0173155.pdf
DOI : 10.1371/journal.pone.0173155.t002

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
ABSTRACT: In the past decade, there has been an increasing number of studies on co-infections between worms and malaria. However, this increased interest has yielded results that have been at times conflicting and made it difficult to clearly grasp the outcome of this interaction. Despite the heterogeneity of study designs, reviewing the growing body of research may be synthesized into some broad trends: Ascaris emerges mostly as protective for malaria and its severe manifestations, whereas hookworm seems to increase malaria incidence. As efforts are made to de-worm populations in malaria endemic areas, there is still no clear picture of the impact these programmes have in terms of quantitative and qualitative changes in malaria.
ISSN: 1475-2875

inserm-00632065
http://www.hal.inserm.fr/inserm-00632065
http://www.hal.inserm.fr/inserm-00632065/document
http://www.hal.inserm.fr/inserm-00632065/file/1475-2875-10-259.pdf
DOI : 10.1186/1475-2875-10-259

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
BACKGROUND: The timing of cardiac surgery after stroke in infective endocarditis (IE) remains controversial. We examined the relationship between the timing of surgery after stroke and the incidence of in-hospital and 1-year mortalities. METHODS: Data were obtained from the International Collaboration on Endocarditis-Prospective Cohort Study of 4794 patients with definite IE who were admitted to 64 centers from June 2000 through December 2006. Multivariate logistic regression and Cox regression analyses were performed to estimate the impact of early surgery on hospital and 1-year mortality after adjustments for other significant covariates. RESULTS: Of the 857 patients with IE complicated by ischemic stroke syndromes, 198 who underwent valve replacement surgery poststroke were available for analysis. Overall, 58 (29.3%) patients underwent early surgical treatment vs 140 (70.7%) patients who underwent late surgical treatment. After adjustment for other risk factors, early surgery was not significantly associated with increased in-hospital mortality rates (odds ratio, 2.308; 95% confidence interval [CI], .942-5.652). Overall, probability of death after 1-year follow-up did not differ between 2 treatment groups (27.1% in early surgery and 19.2% in late surgery group, P = .328; adjusted hazard ratio, 1.138; 95% CI, .802-1.650). CONCLUSIONS: There is no apparent survival benefit in delaying surgery when indicated in IE patients after ischemic stroke. Further observational analyses that include detailed pre- and postoperative clinical neurologic findings and advanced imaging data (eg, ischemic stroke size), may allow for more refined recommendations on the optimal timing of valvular surgery in patients with IE and recent stroke syndromes.
ISSN: 1058-4838

hal-00875143
https://hal.archives-ouvertes.fr/hal-00875143
DOI : 10.1093/cid/cis878
PUBMED : 23074311

Éditeur(s) : HAL CCSD
Résumé : Journée d'études du 27/04/17 « Révolution, dictature, résistance dans le monde américano-caraïbe »
Située au nord de Trinidad et Tobago, l'île de la Grenade fait partie de ces nations caribéennesaujourd'hui indépendantes dont l'histoire révolutionnaire a été singulièrement marquée par lacolonisation, l'esclavage, et plus récemment, par l'interventionnisme américain, au même titre quel'emblématique Cuba. En fait, les deux révolutions sont idéologiquement et historiquement liées, maisconnaîtront des heurs divers. Certes, il est vrai qu'à l'instar de Cuba, la Grenade – en espagnol, laGranada – possède un passé colonial indélébile, qui a lourdement impacté sur la conscience politique etesthétique de son peuple, mais l'histoire retiendra surtout de la Grenade le souvenir d'une révolutionavortée. A plus d'un titre, l'intériorisation de ce trauma, et la résilience qui en découle, représentent descomposantes essentielles du legs historique participant à la formation de l'identité culturelle caribéenne.De fait, celle-ci s'est exprimée au cours des quatre dernières décennies, sous des modes divers, par lebiais des arts et de la littérature, suivant une logique d'extériorisation et d'esthétisation de la blèsoriginelle. Comment donc passer sous silence – autrement dit, censurer, – la violence, et la gravité del'épisode d'occupation militaire américaine, qui se solda en 1983 par l'assassinat du premier ministregrenadien Maurice Bishop, au profit d'enjeux géopolitiques dits « supérieurs » ? Chassez le refoulé, ilreviendra toujours au galop. Telle est la leçon retenue par les artistes-historiens grenadiens qui se sontpenchés sur la question, et dont nous tâcherons d'élucider la portée du travail, aussi bien sur planplastique, esthétique que politique.
https://hal.archives-ouvertes.fr/hal-01664579

Droits : http://creativecommons.org/licenses/by/
hal-01664579
https://hal.archives-ouvertes.fr/hal-01664579
https://hal.archives-ouvertes.fr/hal-01664579/document
https://hal.archives-ouvertes.fr/hal-01664579/file/D%C3%A9-peindre%20la%20r%C3%A9volution%20grenadienne_traumas%2C%20censures%2C%20lib%C3%A9rations_F.%20LEFRANCOIS.pdf

Éditeur(s) : HAL CCSD
Résumé : Does the language in which the instructions are formulat- ed affect the execution of a bilingual's motor task? The first experiment studies whether the language used for the instructions influences the motor performances among bilingual children in situation of learning. Eighty bilin-gual French/Creole children (age means 10.4) were distributed into two experimental groups to learn how to perform a motor task. One group received instructions in French and the other one in Creole. The data suggest that the language of presentation affects the execution of a motor task. Both groups had the same performance level at the beginning of the experiment. We noticed that the group taught in Creole obtained better performances than the group taught in French at the end of the learning situation. The results are discussed in terms of their implications to physical education and motor rehabilitation of bilinguals. The two following experiments reported in the present paper concern (i) the differential imagery value of French and Creole and (ii) the influence of language on the recall of sequences of patterned movements in a bilingual population. Creole words were obtained a higher imagery value than French words, certainly because Creole is an oral and vernacular language. Motor recall scores were better when the sequence was presented in Creole compared to French. The generation of visual images by Creole would facilitate the memorization and recall of new sequences of movements. The effect of language on imagery value of words and motor recall among bilingual French–Creole subjects was discussed in terms of nature of information encoding in each language. The goal of the fourt and last study tries to know the language impact on the movement imagery ability of guadeloupean children. A person is able to represent verbal information with an image (Denis, 1989; Paivio, 1986). The language can he influence this ability on bilingual individuals? If Creole has more to do with image than French (Michelot, 2000), this survey considers a distinct language influence on the mental images vividness specified by guadeloupean children. 123 secondary school pupils (average age 13.45) altogether accepted to fill in the Movement Imagery Questionnaire of Hall and Pongrac (1983). This test enables to measure the rapidity of visual and kinaesthetic images. The “Creole” group (59 children; average age 13. 43) got the MIQ translated in Creole and the “French” group (64 children; average age 13.46) the French version of the test. Finally, language does not generally influence the movement imagery capacity. Yet, the kinaesthetic images are more vivid in French than in Creole for the subjects tested, aged from 11 to 13. The subjects aged from 14 to 16 have, only in Creole, more vivid visual images than the subjects aged from 11 to 13. The language affects the movement imagery ability with age of this guadeloupean children.
L'exécution d'une tâche motrice chez des bilingues est-elle affectée par la langue dans laquelle les consignes sont formulées ? Une première expérience a été menée en vue d'analyser si la langue de présentation des consignes influence les performances motrices d'enfants bilingues en situation d'apprentissage. Quatre-vingt bilingues français/créole (âge moyen : 10,4 ans) ont été répartis dans deux groupes expérimentaux afin d'apprendre à réaliser une tâche motrice, l'un recevant les consignes en français et l'autre en créole. Les données suggèrent que la langue de présentation affecte l'exécution d'une tâche motrice. Le groupe enseigné en créole obtient de meilleures performances en fin d'apprentissage comparativement à celles obtenues par le groupe enseigné en français, alors que les deux groupes ont au départ un niveau comparable. Ces résultats sont discutés sur le plan de leur implication pour l'éducation physique et la réadaptation motrice des bilingues. Les deux expérimentations suivantes évaluent (i) la valeur d'imagerie de mots et (ii) le rappel moteur d'enchaînements auprès de bilingues français–créole en faisant varier la langue de présentation. Les mots en créole, supposés susciter plus facilement des images mentales visuelles, car le créole est une langue orale et vernaculaire, ont effectivement obtenu une cote plus élevée que les mots français sur l'échelle de valeur d'imagerie. L'évocation d'images visuelles facilitant la mémorisation et la planification de séquences de mouvements, les performances de rappel obtenues à partir des consignes en créole ont été supérieures à celles obtenues en français. Les effets de la langue de présentation sur la valeur d'imagerie des mots et le rappel moteur d'enchaînements de morphocinèses auprès des participants bilingues sont discutés en termes de nature d'encodage de l'information verbale dans chacune des langues. L'objectif de cette quatrième et dernière recherche est de connaître l'impact de la langue sur la capacité d'imagerie du mouvement d'enfants guadeloupéens. Un individu peut se représenter des informations verbales sous une forme imagée (Denis, 1989; Paivio, 1986). La langue peut-elle influencer cette capacité chez des individus bilingues ? Le créole étant plus imagé que le français (Michelot, 2000), nous prévoyons une influence distincte de la langue sur le degré de vivacité des images mentales. Cent-vingt-trois collégiens guadeloupéens (âge moyen 13.45) ont rempli un questionnaire d'imagerie du mouvement (MIQ de Hall et Pongrac, 1983) mesurant la vivacité d'images visuelles et kinesthésiques. Un groupe «créole» (59 enfants; âge moyen 13.43) l'a passé en créole et un groupe «français» (64 enfants; âge moyen 13.46) en français. Finalement, la langue n'influence pas la capacité d'imagerie mentale de notre échantillon. Mais la vivacité des images kinesthésiques est supérieure en français chez les sujets de 11 à 13 ans et celle des images visuelles des sujets de 14 à 16 ans est supérieure à celle des sujets de 11 à 13 ans seulement en créole. La langue semble influencer la capacité d'imagerie mentale des sujets en fonction de l'âge.
https://tel.archives-ouvertes.fr/tel-00441944

Droits : info:eu-repo/semantics/OpenAccess
tel-00441944
https://tel.archives-ouvertes.fr/tel-00441944
https://tel.archives-ouvertes.fr/tel-00441944/document
https://tel.archives-ouvertes.fr/tel-00441944/file/These_Anciaux_2003_L_enfant_le_creole_et_l_EPS.pdf

Éditeur(s) : HAL CCSD
Résumé : International audience
(definition, qualities social and/or world) as technological media of the innovation, we shall wonder about the stakes and the impacts of these in the alternative strategies of collective intelligence, as community stand.This brings us to invest more profoundly the community innovation in sustainable development, by a concrete ground : association of ecocitizenship of the Bay of Arcachon., Ecocitizens of the Bay of Arcachon, the association integrated into the CEBA, the Coordination Environment Association of the Bay of Arcachon wich account 29 associations of environnemental protection on the Bay of Arcachon. Our subject is to show from the appropriation of ICTS and new modes of existence of the technical objects that the social innovation is born and diversifies in a intercultural way from complex hybridizations between economic concerns, relations with public authorities and social utility. Does not this define a new imagination of the innovation and the change where the individual via the groups has a renewed responsibility and which sometimes is to be re-qualified ?
Dans cet article, après un état des lectures sur les réseaux, base de notre cadre méthodologique (définition, type, qualités sociaux et/ou mondiaux) en tant que supports technologiques de l’innovation, nous nous interrogerons sur les enjeux et les impacts de ceux-ci dans les stratégies alternatives d’intelligence collective, en tant que prise de position communautaire. Ceci nous amène à investir plus profondément l’innovation communautaire en développement durable, par un terrain concret : association d’écocitoyenneté du Bassin d’Arcachon, Ecocitoyens du Bassin d’Arcachon, association intégrée à la CEBA l’Association Coordination Environnement du Bassin d’Arcachon qui compte 29 associations de protection de l’environnement sur le Bassin d’Arcachon Notre propos est de montrer à partir de l’appropriation des TIC et de nouveaux modes d’existence des objets techniques que l’innovation sociale naît et se diversifie de façon interculturelle à partir d’hybridations complexes entre préoccupations économiques, relations avec les pouvoirs publics et utilité sociale.Ceci ne définit-il pas un nouvel imaginaire de l’innovation et du changement où l’individu via les groupes a une responsabilité renouvelée et qui est parfois à requalifier ?
Les écosystèmes numériques et la démocratisation informationnelle : Intelligence collective, Développement durable, Interculturalité, Transfert de connaissances
Schoelcher, France

hal-01258348
https://hal.univ-antilles.fr/hal-01258348
https://hal.univ-antilles.fr/hal-01258348/document
https://hal.univ-antilles.fr/hal-01258348/file/Catherine%20PASCAL.pdf

Éditeur(s) : HAL CCSD
Résumé : Neotropical forests shelter an astonishing and underrated biodiversity. The integrity and stability of these natural ecosystems are threatened by human-induced environmental changes. Therefore, highlighting the determinants of ecosystem functioning, be they natural or anthropogenic, is a daunting but paramount scientific challenge. The intrinsic complexity of highly diversified ecosystems arouses both conceptual and logistical difficulties, which we handle, by manipulating tiny ecosystems, the tank bromeliads. The leaves of tank bromeliads form wells that hold rainwater and intercept leaf litter, allowing for a simple invertebrate aquatic community to thrive. These plants can be exhaustively sampled, are naturally replicated, and widely distributed.From local to biogeographic scales, this thesis aims at understanding how these communities respond to the natural heterogeneity of Amazonian forests, and at predicting the impacts of human-induced disturbances on the structure and functioning of these communities, using in situ and lab experiments. Particular focus is attributed to the influence of some aspects of climate changes (e.g., warming, and various precipitations scenarios) on individual physiology, behavior, and trophic interactions.
Les forêts néotropicales accueillent une importante biodiversité encore méconnue. L’intégrité des écosystèmes naturels est menacée par les changements environnementaux (e.g., réchauffement climatique, destruction des habitats), par conséquent, identifier les facteurs structurants, naturels et anthropiques, du fonctionnement des écosystèmes, représente un défi scientifique crucial. L’inhérente complexité de ces milieux diversifiés pose de nombreux problèmes conceptuels et logistiques comme un échantillonnage exhaustif et/ou l’identification des espèces. Les broméliacées à réservoirs sont des écosystèmes miniatures adéquats pour pallier ces difficultés, car elles retiennent de l’eau de pluie et accumulent de la matière organique au creux de leurs feuilles, permettant ainsi de supporter des réseaux trophiques simples d’invertébrés aquatiques. Elles peuvent être échantillonnées exhaustivement, ont une forte abondance locale, et une large aire de répartition. De l’échelle locale à biogéographique, les travaux de cette thèse visent d’abord à comprendre comment ces communautés se structurent en réponse à l’hétérogénéité naturelle des forêts amazoniennes (e.g., ouverture de la canopée, fluctuations climatiques saisonnières), puis tente de prédire, par le biais d’expérimentations in situ et au laboratoire les réponses structurelles et fonctionnelles de ces communautés à divers scénarios de changement climatique. Une attention particulière a été portée sur l’impact de la température et des précipitations sur la physiologie et le comportement d’espèces clefs, et sur les interactions trophiques au sein des communautés.
https://tel.archives-ouvertes.fr/tel-01405025

NNT : 2015YANE0003
tel-01405025
https://tel.archives-ouvertes.fr/tel-01405025
https://tel.archives-ouvertes.fr/tel-01405025/document
https://tel.archives-ouvertes.fr/tel-01405025/file/These-DEZERALD-Diffusion.pdf

Éditeur(s) : HAL CCSD L'Harmattan
Résumé : International audience
Pourquoi un autre livre sur la culture Hip-Hop ? Parce que comme toute culture, elle est dynamique et ne se laisse pas dompter. Elle possède l’essencedes cultures, elle recherche le contact avec l’autre. Même si le mouvement possède une histoire, une tradition réelle, il ne se réduit pas au rap, ni auxafricains-américains, ni aux clichés déversés par les clips vidéos. Le Hip-Hop doit son dynamisme et sa longévité à sa capacité à entrer en contact avecd’autres cultures et à se laisser infiltrer. Se faisant, il est également porteur de contradictions. Parfois victime de son propre succès, le mouvement Hip-Hop est le résultat d’échanges complexes, de conditions sociopolitiques nourries par des sentiments de désillusion et d’aliénation. De manière élémentaire, nous pouvons le qualifier de « produit de l’Amérique d’après la lutte des droits civiques ».C’est un ensemble d’expressions culturelles conçu par la jeunesse des communautés africaine-américaine, latino-américaine et caribéenne-américaineà New York et ses environs durant les années soixante-dix. Son moyen d’expression le plus populaire a été la musique rap ; néanmoins la danse, legraffiti, la mode vestimentaire, l’art audiovisuel, la criminalité, le sport et le commerce sont aussi ses « terrains de jeu » (Nelson, 1998 :8). La « générationHip-Hop » a entre 13 et 40 ans. Elle a grandi avec ces expressions Hip-Hop comme repère socioculturel, politique et idéologique. Le mouvement continued’avoir un impact considérable sur l’industrie vestimentaire, la presse écrite, l’enseignement, la télévision, le langage, la sexualité, les relations hommefemme, les politiques sociales et économiques aux États-Unis et dans le reste du monde. Parce qu’elle a capturé l’attention et l’imagination d’un grand nombre individus d’origines ethniques et sociales très diverses, elle mérite qu’on s’y intéresse avec beaucoup de sérieux. Nous chercherons à interroger cette culture fertile à la lumière de plusieurs grands thèmes, à savoir : la société étasunienne, la politique, le multiculturalisme, les substances narcotiques, l’Afrique, la mort, la "glocalisation", le capitalisme et l’interculturalité.
https://hal.univ-antilles.fr/hal-01379678

ISBN : 9782296129313
hal-01379678
https://hal.univ-antilles.fr/hal-01379678

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
In a period of agricultural decline in the uplands of Europe, agriculture is ceasing to provide the primary rationale for the organisation, utilisation and functioning of rural space. Policy reform, market trends and changes to the way citizens and consumers think about the countryside all suggest a need for thinking strategically about the future development of these areas. However, without a broad involvement of stakeholders, land use conflicts, and social and cultural conflicts in general, may increase. Involving stakeholders in upland areas can be facilitated by using scenario technique and by discussing alternative futures in local stakeholder panels. In this paper we present four scenarios of land-use change for the year 2030, and their assessments by stakeholder panels in Scotland, France, Norway, Switzerland, Slovakia and Greece. The aim of the paper is to explore the ways in which stakeholders in these locations advocate and assess these scenarios. We also explore how stakeholders in different countries weight the visual landscape impacts, the livelihood and biodiversity aspects of the scenarios in their assessment, and the reasons for their prioritising. The cross-country analysis shows that stakeholders across the study areas are united in their overall rejection of agricultural liberalisation, advocating a production-oriented, but multifunctional and environmentally-friendly agriculture that maintains landscapes and biodiversity.
ISSN: 0743-0167

halshs-01227527
https://halshs.archives-ouvertes.fr/halshs-01227527
DOI : 10.1016/j.jrurstud.2007.04.001

Éditeur(s) : HAL CCSD Fondazione Lingue e Culture
Résumé : International audience
Inwieweit der Gemeinsame Europäische Referenzrahmen (GER) zur Unterrichtsplanung und ganz besonders zur Leistungsbewertung benutzt werden kann, untersuchen die beiden Autoren am Beispiel der DELF- und DALF- Diplome, die ab November 2007 in die Beurteilung von Französisch als Fremdsprache an den Schweizer Schulen (Ende Sek I) integriert werden sollen. Dazu müssen die Bewertungskriterien in den verschiedenen Testbereichen nicht nur transparent und vergleichbar sein und auf jedem Niveau bestimmten qualifikativen Aspekten der gesprochenen bzw. der geschriebenen Sprache genügen, sondern auch eine in Zeit und Aufwand angemessene Durchführung der Prüfungen gewährleisten.Im Beitrag von Riba und Luscher wird vor allem die Rolle vorausgehender Studien und Probetests, soliden Prüfertrainings, nachfolgender Vergleichskontrollen und eventueller Korrekturmassnahmen innerhalb der Prüfungszentren deutlich. Sie verweisen aber auch auf die Anbindung von Prüfungsaufgaben an das “normale” Unterrichtsgeschehen und schliesslich auf die Grenzen messbarer Leistungen: So lässt sich z.B. die interkulturelle Dimension nur schwer in festen Kriterien fassen und bewerten, was sich auch in dem unterschiedlichen Stellenwert ausdrückt, der Prüfungen in verschiedenen Kulturen zukommt. Am Ende bekennen sich die Autoren zu ihrem Credo, dass Sprachtests die Autonomie der Lerner fördern und deshalb so gerecht und zuverlässig wie möglich sein müssen. (Red.)
Après la publication du cadre européen commun de référence pour les langues, le Centre international d'études pédagogiques de Sèvres a procédé à la réforme des certifications en français langue étrangère, le DELF et le DALF. Dans cet article, le responsable du bureau du DELF et du DALF au CIEP, et le responsable de ces certifications en Suisse analysent l'impact que le Cadre européen a ou peut avoir sur la planification des enseignements/apprentissages en français langue étrangère.
Babylonia

Droits : info:eu-repo/semantics/OpenAccess
halshs-01400371
https://halshs.archives-ouvertes.fr/halshs-01400371
https://halshs.archives-ouvertes.fr/halshs-01400371/document
https://halshs.archives-ouvertes.fr/halshs-01400371/file/Le%20CER%20instrument%20de%20planification%20des%20enseignements%20et%20d%E2%80%99%C3%A9valuation%20des%20apprenants.pdf

Éditeur(s) : Public Library Science
Résumé : Background: Resolving threats to widely distributed marine megafauna requires definition of the geographic distributions of both the threats as well as the population unit(s) of interest. In turn, because individual threats can operate on varying spatial scales, their impacts can affect different segments of a population of the same species. Therefore, integration of multiple tools and techniques - including site-based monitoring, genetic analyses, mark-recapture studies and telemetry - can facilitate robust definitions of population segments at multiple biological and spatial scales to address different management and research challenges. Methodology/Principal Findings: To address these issues for marine turtles, we collated all available studies on marine turtle biogeography, including nesting sites, population abundances and trends, population genetics, and satellite telemetry. We georeferenced this information to generate separate layers for nesting sites, genetic stocks, and core distributions of population segments of all marine turtle species. We then spatially integrated this information from fine-to coarse-spatial scales to develop nested envelope models, or Regional Management Units (RMUs), for marine turtles globally. Conclusions/Significance: The RMU framework is a solution to the challenge of how to organize marine turtles into units of protection above the level of nesting populations, but below the level of species, within regional entities that might be on independent evolutionary trajectories. Among many potential applications, RMUs provide a framework for identifying data gaps, assessing high diversity areas for multiple species and genetic stocks, and evaluating conservation status of marine turtles. Furthermore, RMUs allow for identification of geographic barriers to gene flow, and can provide valuable guidance to marine spatial planning initiatives that integrate spatial distributions of protected species and human activities. In addition, the RMU framework - including maps and supporting metadata - will be an iterative, user-driven tool made publicly available in an online application for comments, improvements, download and analysis.
Plos One (1932-6203) (Public Library Science), 2010-12 , Vol. 5 , N. 12 , P. -

Droits : 2010 Plos One
http://archimer.ifremer.fr/doc/00028/13926/11308.pdf
DOI:10.1371/journal.pone.0015465
http://archimer.ifremer.fr/doc/00028/13926/

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
BACKGROUND: Dengue fever is the most important arboviral infection that affects humans, particularly in tropical and subtropical regions. Here, we provide the first comprehensive overview of the severity of dengue epidemics in French Guiana. METHODOLOGY/PRINCIPAL FINDINGS: We monitored hospitalized cases between 2008 and 2013. Detailed clinical features and biological parameters were collected on a daily basis from all cases. Among the 1,356 cases, 216 (16%) were classified according to the WHO 2009 classification as dengue without warning signs (WS), 926 (68%) were classified as dengue with WS and 214 (16%) were classified as severe dengue. The severity rates were similar between the three major epidemics that occurred during the study period, whereas the hospitalization rate was highest in 2013. Fluid accumulation, aspartate aminotransferase (ASAT) counts>193 IU/L and platelet counts<75,000 cells/mm3 were associated with dengue severity. CONCLUSIONS/SIGNIFICANCE: Our findings provide a recent epidemiological description of the severity of dengue epidemics in French Guiana. These results highlight the potential impacts and consequences of implementing the WHO 2009 classification on hospital activity. Future studies should include virological and immunological investigations of well-documented serum samples.
ISSN: 1932-6203

hal-01477201
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01477201
DOI : 10.1371/journal.pone.0172267
PUBMED : 28196111

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Inorganic arsenic is a toxic environmental contaminant to which humans are mainly exposed through drinking water. This metalloid impairs functions of several key immune cells. Particularly, it reduces IL-2 secretion and proliferation of blood peripheral mononuclear cells stimulated by lectins that, however, do not mimic physiological T cell activation. The present study used isolated human T cells activated, in a more physiological manner, through stimulation with CD3/CD28 antibodies, to carefully analyze the impact of arsenic on T cell proliferation and cytokine expression. We demonstrate that non cytotoxic concentrations of sodium arsenite (As(III), 0.25-2μM) significantly reduce T cell proliferation by increasing the percentage of non dividing cells blocked in G1 phase and by preventing cyclin D3 and CDC25A expression. They also markedly, although not totally, reduces IL-2 expression at both mRNA and protein levels; however, metalloid-dependent inhibition of T cells could not be reversed by addition of recombinant IL-2. In addition, As(III) markedly reduces secretion of interferon-γ without impairing that of IL-4 and IL-13; it also decreases interferon-γ mRNA levels but increases those of IL-13. Finally, simultaneously to its immune effects, As(III) rapidly and potently increases expression of the redox-sensitive genes HMOX1, NQO1 and GCLM in activated T cells without altering the levels of reactive oxygen species. In conclusion, our results demonstrate that As(III) inhibits T cell proliferation, independently of IL-2, and alters the Th balance of cytokines secreted by co-stimulated T cells which thus constitute direct targets of this major environmental contaminant.
ISSN: 0300-483X

inserm-00872848
http://www.hal.inserm.fr/inserm-00872848
DOI : 10.1016/j.tox.2012.05.025
PUBMED : 22683347

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Maternal affective disorders are frequently treated with selective serotonin reuptake inhibitor medications (SSRIs); with up to 10% of women being prescribed these medications during pregnancy. Infant development depends on the early serotonergic environment, which is altered by perinatal SSRIs, raising concern about how these medications affect neural outcomes. While clinical and preclinical research suggests an impact of SSRIs on the developing brain, more research is needed to determine the effects on neuroplasticity, the serotonergic system, and the hypothalamic-pituitary-adrenal axis in neural regions mediating behavior. The current work investigated the effects of the SSRI, fluoxetine, on the serotonergic system in the prefrontal cortex (PFC) during pre-adolescence, and changes to synaptic markers and glucocorticoid receptor density in the cingulate cortex (medial PFC) of pre-adolescent and adult Sprague-Dawley male and female rats. To model aspects of Perinatal Depression and maternal anxiety, pre-gestational maternal stress was used resulting in male and female offspring from 4 groups: 1) control, 2) perinatal fluoxetine exposed, 3) pre-gestational maternal stress exposed, and 4) pre-gestational maternal stress + fluoxetine. Perinatal fluoxetine prevented the effects of maternal stress on 5-HT levels and 5-HT turnover ratio in the PFC of pre-adolescent offspring, particularly in females. However, pre-gestational stress reduced synaptophysin and PSD-95 densities in the cingulate cortex, effects that were more pronounced in males. Interestingly, perinatal fluoxetine exposure reduced GR density in adult males in this same brain area. Together, results show differential effects of perinatal SSRIs and pre-gestational maternal stress on neurodevelopment in the PFC of males and females.
ISSN: 0028-3908

hal-01647158
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01647158
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01647158/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01647158/file/Gemmel%20-%20Perinatal%20fluoxetine%20prevents%20the%20effect.pdf
DOI : 10.1016/j.neuropharm.2017.10.009

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
In order to perform a human and ecological risk assessment of pharmaceutical products (PPs) in natural waters, it is necessary to accurately quantify a broad variety of PPs at low concentrations. Although numerous currently implemented analytical methodologies, less is known about the preservation of PPs in natural water samples within the period before analysis (holding time, storage conditions). This paper is the first literature review about the stability of PPs in natural waters (surface and groundwaters) during sample storage. The current work focuses on a comparison of the performances of the available preservation techniques (filtration, container materials, storage temperature, preservative agents, etc.) for PPs in samples. All 58 reviewed PPs may be successfully stabilized during 7 days in surface waters by at least one appropriate methodology regarding temperature, acidic and non-acidic preservatives. When temperature is not a sufficient preservation parameter f! or some PPs (hormones and fluoxetine) its combination with the addition of chemical agents into the samples may prolong the integrity of the PPs during storage in surface water. There is a strong need to use standard protocols to assess and compare the stability of PPs in environmental water matrices during storage as well as during analytical preparation or analysis (European criteria 2002/657/EC). Since the stability of PPs during sample storage is a critical parameter that could call into question the quality of the data provided for the concentrations, the design of stability studies should rigorously take into account all critical parameters that could impact the concentrations of the PPs with time.
Talanta

insu-00839186
https://hal-insu.archives-ouvertes.fr/insu-00839186
DOI : 10.1016/j.talanta.2013.01.042