Résumé : The development of large pelagic fishing in the French Antilles is an integral part of a difficult economic situation of the fishing sector in Martinique where this development can seem like a solution to increasingly acute problems. Indeed, for the regulatory authorities as well as for many participants in the sector, it is imperative to find solutions to the lack of profitability of a part of the fishing ships and to confront the regular increase of the share of imports in supplying Martinique with seafood. This question about the possibilities of developing large pelagic fishing is not new since it is already mentioned in the Notice from the Economic and Social Committee of the Martinique Region in 1982. We will not show in this document a detailed analysis of small-scale fishing in Martinique. Since the latter has been abundantly studied by the team of the Caribbean Oceanological and Halieutic Research Centre (PROHC) between 1985 and 1987, we will take up these principal conclusions (with which we are in full agreement) and bring them up to date based on data collected during our mission from 11 to 24 April 1988. The first section devoted to the supply structure (local fishing and imports) will attempt to define under what conditions large pelagic fishing can be developed. The second section will address marketing and demand. Indeed, at the same time as the problems of developing large pelagic fishing, we are faced with the question of the organisation of seafood markets. This organisation is a fundamental issue for the small-scale fishing sector in the French Antilles since its long-term future depends upon it by setting different prices and amounts exchanged according to the structure it is given. We will come to a conclusion on the economic conditions of developing a large pelagic fishery and organising a market, this based on research and study work already done. We will indicate which investigations must be conducted to complete the set of factors for decision support in this area. To perform this assessment, we reconstructed from the long series 1970-1986 (sometimes with significant inadequacies): these are presented as an appendix.
(OCR non controlé) Le développement de la pêche de grands pélagiques dans les Antilles Françaises s'inscrit dans un contexte économique difficile du secteur de la pêche en Martinique où ce développement peut apparaître comme une solution à des problèmes de plus en plus aigus. En effet, pour les autorités de tutelle ainsi que pour de nombreux intervenants dans le secteur, il est impératif de trouver des solutions au manque de rentabilité d'une partie des unités de pêche et de faire face à l'augmentation régulière de la part des importations dans l'approvisionnement de la Martinique en produits de la mer. Cette question sur les possibilités d'un développement de la pêche de grands pélagiques n'est pas nouvelle puisqu'elle est déjà évoquée dans l'Avis du Comité Economique et Social de la Région Martinique en 1982. On ne présentera pas dans ce document une analyse détaillée de la pêche artisanale en Martinique. Celle-ci ayant été abondamment étudiée par l'équipe du Pôle de Recherche Océanologique et Halieutique Caraïbe (PROHC) entre 1985 et 1987, on reprendra ces principales conclusions (avec lesquelles nous sommes en plein accord) en les actualisant à partir des informations recueillies lors de notre mission du 11 au 24 avril 1988. La première section consacrée à la structure d'offre (pêche locale et importations) s'attachera à définir dans quelles conditions peut être développée une pêche de grands pélagiques. Là seconde section traitera de la commercialisation et de la demande. En effet parallèlement aux problèmes de développement d'une pêche de grands pélagiques, se pose la question de l'organisation du marché des produits de la mer. Cette organisation est un enjeu primordial pour le secteur de la pêche artisanale dans les Antilles Françaises puisqu'elle conditionne son avenir à long terme en définissant des prix et des quantités échangées différents suivant la structure qu'on lui donne. On conclura sur les conditions économiques du développement d'une pêche de grands pélagiques et de l'organisation d'un marché, ceci à partir des travaux de recherche et des études déjà réalisés. On indiquera quelles investigations doivent être menées pour compléter l'ensemble des éléments d'aide à la décision dans ce domaine. Pour effectuer cette évaluation, on a reconstituer des séries longues 1970-1986 (parfois avec des carences importantes) : celles-ci sont présentées en annexe.

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/1988/rapport-2519.pdf
http://archimer.ifremer.fr/doc/00000/2519/

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Magnetic Resonance Imaging (MRI), a reference examination for cardiac morphology and function in humans, allows to image the cardiac right ventricle (RV) with high spatial resolution. The segmentation of the RV is a difficult task due to the variable shape of the RV and its ill-defined borders in these images. The aim of this paper is to evaluate several RV segmentation algorithms on common data. More precisely, we report here the results of the Right Ventricle Segmentation Challenge (RVSC), concretized during the MICCAI'12 Conference with an on-site competition. Seven automated and semi-automated methods have been considered, along them three atlas-based methods, two prior based methods, and two prior-free, image-driven methods that make use of cardiac motion. The obtained contours were compared against a manual tracing by an expert cardiac radiologist, taken as a reference, using Dice metric and Hausdorff distance. We herein describe the cardiac data composed of 48 patients, the evaluation protocol and the results. Best results show that an average 80% Dice accuracy and a 1cm Hausdorff distance can be expected from semi-automated algorithms for this challenging task on the datasets, and that an automated algorithm can reach similar performance, at the expense of a high computational burden. Data are now publicly available and the website remains open for new submissions (http://www.litislab.eu/rvsc/).
ISSN: 1361-8415

hal-01141170
https://hal.archives-ouvertes.fr/hal-01141170
PUBMED : 25461337

Résumé : If Sea Bass fish farming (Dicentrarchus labrax L.) is currently experiencing an increase in Southern Europe, it is vital, in order to better reflect raising structures, to control its wastes. In order to do so, quantifying this species' wastes is essential to be able to present simple excretion ratios, easily useable by the farmer. Those ratios have been based on nitrogen, phosphorus and carbon masses established on intensive farming and 4 batches belonging to his stock (averaging 24, 5 to 362, 5 g). Each batch was followed up during the course of 1 month and fish farming in its entirety for 2 months. Mass assessments for nitrogen and phosphorus were level ((intrants = extrants) but never precise, contrary to what can be found in bibliography. The main wastes defined were linked to the biomasses found as well as the food quantity fed. Sea Bass carbon excretion could not be clearly defined. According to these follow ups, phosphorus would be the element better utilized by Sea Bass considering nutritional provision. Nitrogen, phosphorus and carbon quantities rejected through farming are very high since for nitrogen and carbon, 90% of the ingestion would be rejected in the environment.
INTRODUCTION : Les pêcheries de langoustine de Mer Celtique se situent essentiellement dans les subdivisions Vllg et Vllh. La réglementation communautaire sur les maillages à langoustine y a été appliquée à partir de 1978. L'emploi d'un maillage dérogataire pour la pêche de la langoustine n'est possible que si le pourcentage d'espèces protégées par une taille marchande pêchées en même temps que la langoustine est inférieur à un seuil déterminé en relation avec le maillage en vigueur. L'application de cette réglementation s'est effectuée suivant un calendrier particulier Avec un pourcentage d'espèces protégées supérieur à 60 %, la pêche est considérée comme dirigée vers le poisson et le maillage est celui de la réglementation générale, soit 80 mm. En fait, comme cela a été mentionné à maintes reprises, sous la pression de cette réglementation contraignante, les flottilles et les techniques de pêche ont évolué très rapidement si bien que le pouvoir de capture de ces navires, aussi bien sur la langoustine que sur le poisson, a considérablement augmenté. Dans la majorité des cas, la flexibilité est devenue la règle et l'adoption du maillage de 80 mm tend à se généraliser. Ces navires s'orientent toujours momentanément vers la pêche la plus rentable, la langoustine demeurant l'espèce-cible, même si elle ne constitue pas toujours pondéralement l'essentiel des captures. Un des reproches majeurs fait aux langoustiniers de Mer Celtique était la destruction possible d'immatures de poissons. Une évaluation de ces rejets a été réalisée en 1980, soit donc avec un maillage situé entre 55 et 60 mm. Pour la plupart des espèces, les rejets sont anecdotiques en raison vraisemblablement d'une distribution spatiale différente des immatures et des adultes. Dans le cas du merlan, les immatures sont concentrés dans les zones côtières en hiver et ne sont capturés que si les langoustiniers sont amenés à abandonner la zone des bancs centraux en raison, en particulier, du mauvais temps. Seuls le merlu et la cardine présentent des pourcentages de rejets très importants car ils sont inféodés aux mêmes fonds vaseux que la langoustine, et leurs migrations trophiques, s'il en existe, ont lieu dans ces aires de dépôts sédimentaires au pied des hauts fonds. Dans ces premières évaluations, le volume observé des rejets de merlu étaient pour le moins inquiétant et laissait supposer, soit qu'il existait sur le fond au moment du recrutement des quantités énormes d'immatures soit que la sélectivité du chalut était abaissée par la présence de la langoustine. Ce deuxième point a été vérifié depuis et il semble que la sélectivité du merlu avec ou sans chalut à langoustine soit strictement la même. Les rejets de langoustine n'ont pas été comptabilisés car les valeurs auraient été inexploitables en raison de la différence entre la taille marchande communautaire, soit 25 mm de longueur céphalothoracique et la taille française soit 34, 5 mm. Ils seraient respectivement de 1, 75 % en nombre dans le premier cas contre 55 % dans le deuxième. En raison des modifications importantes intervenues dans l'aménagement des pêches dans cette zone, il était indispensable de refaire une évaluation pondérale des rejets : Pour obtenir des compositions en taille des espèces ne se prêtant pas aux analyses habituelles sur les âges. Pour calculer des courbes de tri manuel sur les espèces dont il est difficile d'évaluer les rejets en routine, mais seulement dans la mesure où les rejets se superposent à la fraction commerciale de la capture.

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/1985/rapport-1753.pdf
http://archimer.ifremer.fr/doc/00000/1753/

Éditeur(s) : HAL CCSD
Résumé : Croton urucurana Baillon (Euphorbiaceae), plant species popularly known in Brazil as “sangra-d’água”, is commonly found in Mato Grosso do Sul State (midwestern Brazil), where its latex is popularly used to treat several types of cancer. Despite the ethnopharmacological significance of the species, no phytochemical or cytotoxic studies of its latex have been published. In this context, the aim of the present study was to assess the cytotoxic activity of crude extracts, fractions and isolated compound from the latex of C. urucurana and to investigate the effects of crourorb A1 on the viability, apoptosis, cell cycle and cell migration of human hepatocarcinoma cell lines (Huh-7). Also, we have evaluated the viability of Huh-7 cells treated with crourorb A1 in 3D collagen gels. The cytotoxicity was detected using the sulforhodamine B (SRB) assay against six human cancer cells lines and one nontumor NIH/3T3 cell line (murine fibroblast). Studies on the mechanism of cell death of crourorb A1 were conducted in different test systems in vitro. The bioactive ethyl acetate phase obtained from the latex of C. urucurana afforded a novel cyclic peptide, [1−9-NαC]-crourorb A1, that proved active against NCIADR/ RES (ovary, multidrug-resistance phenotype) cells with the same potency as doxorubicin (positive control) and inactive up to the highest concentration tested against nontumor NIH/3T3 cells (GI50 = > 250 μg/mL). Crourorb A1 treatment decreases the cell viability of Huh-7 at dose and time dependent manner associated with induction of apoptosis by caspase 3/7 activation and increasing expression of pro-apoptotic proteins: Bak, Bid, Bax, Puma, Bim, and Bad and clived-caspase3 protein. The JNK/MAP pathway is involved in this induced cell death. Crourorb A1 effect is also associated with G2/M phase cell cycle arrest. In parallel, we observed that crourorb A1 treatment resulted in an increase of cyclin-dependent kinase (CDK1), cyclin B1 and cyclin D1 expressions. A significant reduction of Huh-7 cells migration by crourorb A1 can be assessed and we also show that cells grown on 3D collagen gels exhibited increased resistance to crourorb A1 when compared to 2D cell culture.
Croton urucurana Baillon (Euphorbiaceae), est une plante très connue et utilisée en médecine traditionnelle au Brésil, la «sangra-d’água» retrouvée dans l'État du Mato Grosso do Sul (région Centre-Ouest du Brésil). Son latex est abondamment utilisé en médecine traditionnelle dans le traitement de plusieurs types de cancer. En dépit de son importance ethnopharmacologique, on ne trouve aucune étude sur sa composition chimique ou sur sa potentielle activité anti-cancéreuse. L’objectif de ce travail a été d'évaluer l'activité cytotoxique des extraits totaux, fractions d’extraits et de molécules purifiées, isolées du latex de C. urucurana. Nous avons étudié plus particulièrement les effets du crourorb A1 sur la viabilité, l'apoptose, le cycle cellulaire et la migration de cellules issues de carcinome hépatocellulaire humaine (Huh-7). Nous avons également évalué l’effet du crourorb A1sur la viabilité des cellules Huh-7 cultivées dans les gels de collagène en 3D. L' activité cytotoxique ont été réalisées par le test à la sulforhodamine B sur six lignées cellulaire cancéreuses et sur une lignée cellulaire non cancéreuse de fibroblastes murins, les cellules NIH/3T3. L'étude phytochimique de la fraction ‘acétate d'éthyle’ du latex de C. urucurana bioguidé a permis d’obtenir un nouveau cyclopeptide que nous avons nommé [1-9-NαC]-crourorb A1. Le crourorb présente une cytotoxicité puissante sur la lignée cellulaire cancéreuse NCI-ADR/RES (ovaire, le phénotype de multirésistance) à un niveau équivalent à celle de la doxorubicine (témoin positif). Ce composé est de plus pratiquement inactif (GI50 = >250 μg/mL) sur la lignée non cancéreuse NIH/3T3. L'évaluation de la cytotoxicité in vitro du crourorb A1 (test wst1) sur les cellules Huh-7 a démontré que la viabilité des cellules est inhibée de manière dose et temps-dépendant. Nous avons mesuré une forte activation des caspases 3 et 7 et une nette augmentation de l’expression des protéines pro-apoptotiques (Bak, Bid, Bax, Puma, Bim et Bad) ainsi que de la caspase 3 clivée par le crourorb A1. Nous avons également déterminé que la voie de signalisation JNK-MAPkinase semble nécessaire à l’induction de la mort cellulaire des cellules Huh-7 traitées au crourorb A1. Le crourob A1 induit un arrêt du cycle cellulaire en phase G2/M. En parallèle, les expressions de la cycline-dépendante kinase CDK1, des cyclines B1 et D1 sont augmentées après traitement au crourorb A1. De plus, le crourorb A1 a un effet inhibiteur significatif de la migration des cellules Huh-7, en présence ou absence de mitomycine C. Nous avons également confirmé, l’effet inhibiteur du crourob A1 sur la viabilité des cellules Huh7 cultivées en 3D dans les gels de collagène 1 et démontré que les cellules cultivées en 3D semblent plus résistantes au crourorb A1 par rapport aux cultures en monocouche 2D.
Croton urucurana Baillon (Euphorbiaceae) é uma espécie arbórea conhecida popularmente no Brasil como “sangra d´água”, comumente encontrada no estado de Mato Grosso do Sul, onde seu látex tem sido utilizado na medicina popular no tratamento de vários tipos de câncer. Apesar de sua importância etnofarmacológica, não há relatos de estudos relacionados à sua composição química ou atividades anticâncer na literatura. Nesse contexto, o objetivo do presente estudo foi avaliar a atividade citotóxica de extratos, fases, frações e da substância isolada do látex de C. ururucurana e investigar os mecanismos celulares e moleculares in vitro responsáveis pela citotoxicidade da substância isolada considerando seu potencial apoptótico e influência sobre a progressão do ciclo celular em uma linhagem de hepatocarcinoma celular humano (Huh-7), bem como, os efeitos desta substância sobre a migração e viabilidade de células Huh-7 cultivadas em geis de colágeno em 3D. O ensaio de citotoxicidade in vitro foi realizado com o corante sulforrodamina B (SRB) em seis linhagens de células neoplásicas humanas e uma linhagem de células não neoplásicas NIH/3T3 (fibloblasto murinho). Os estudos de mecanismos de ação com crourorb A1 foram conduzidos em diferentes sistemas-teste in vitro. O estudo fitoquímico biomonitorado da fase bioativa acetato de etila do látex de C. urucurana resultou no isolamento de um novo ciclopeptídeo denominado [19-NαC]-crourorb A1, que apresentou potente atividade citotóxica frente à linhagem de células neoplásicas NCI-ADR/RES (ovário com fenótipo de resistência a múltiplos fármacos), com a mesma potência que a doxorrubicina (controle positivo), e foi inativa até a maior concentração testada (GI50 = >250 μg/mL) frente à linhagem de células não neoplásicas 3T3. A exposição de células Huh-7 ao crourorb A1 resultou em uma diminuição da viabilidade celular de maneira dose e tempo-dependentes. Nós observamos um aumento da atividade de caspases 3 e 7 e um aumento da expressão de proteínas próapoptóticas (Bak, Bid, Bax, Puma, Bim e Bad) e caspase 3 clivada após tratamento com crourorb A1. Além disso, observamos que a via de sinalização celular MAP/JNK foi necessária para induzir a morte celular em células Huh-7 tratadas com crourorb A1. Os efeitos de crourorb A1 foram também associados com o acúmulo de células na fase G2/M do ciclo celular. Em paralelo, as expressões da cinase dependente da ciclina (CDK1), ciclina B1 e ciclina D1 foram aumentadas após tratamento com crourorb A1. Foi demonstrado também o envolvimento de crourorb A1 na redução da migração de células Huh-7 cultivadas na presença e ausência de mitomicina C. A avaliação da viabilidade de células Huh-7 cultivadas em geis de colágeno em 3D apontou uma maior resistência destas células ao crourorb A1 quando comparadas com a cultura de células em 2D.
https://tel.archives-ouvertes.fr/tel-01478286

NNT : 2016REN1B010
tel-01478286
https://tel.archives-ouvertes.fr/tel-01478286
https://tel.archives-ouvertes.fr/tel-01478286/document
https://tel.archives-ouvertes.fr/tel-01478286/file/DE-MATOS-CANDIDO-BACANI-Priscila.pdf

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
The natural history of pulmonary Langerhans cell histiocytosis (PLCH) has been unclear due to the absence of prospective studies. The rate of patients who experience an early progression of their disease is unknown. Additionally, conflicting effects of smoking cessation on the outcome of PLCH have been reported. In this prospective, multicentre study, 58 consecutive patients with newly diagnosed PLCH were comprehensively evaluated over a two-year period. Our objectives were to estimate the incidence of early progression of the disease and to evaluate the impact of smoking status on lung function outcomes. Lung function deterioration was defined as a decrease of at least 15% in FEV1 and/or FVC and/or DLCO, compared with baseline values. At each visit, smoking status was recorded based on the patients' self-reports and urinary cotinine measurements that were blinded for the patients. The cumulative incidence of lung function outcomes over time was estimated using the non-parametric Kaplan-Meier method. Multivariate Cox models with time-dependent covariates were used to calculate the hazards ratios of the lung function deterioration associated with smoking status with adjustment for potential confounders. The cumulative incidence of lung function deterioration at 24 months was 38% (22% for FEV1 and DLCO, and 9% for FVC). In the multivariate analysis, smoking status and PaO2 at inclusion were the only factors associated with the risk of lung function deterioration. The patients' smoking statuses markedly changed over time. Only 20% of the patients quit using tobacco for the entire study period. Nevertheless, being a non-smoker was associated with a decreased risk of subsequent lung function deterioration, even after adjustment for baseline predictive factors. By serial lung computed tomography, the extent of cystic lesions increased in only 11% of patients. Serial lung function evaluation on a three- to six-month basis is essential for the follow-up of patients with recently diagnosed PLCH to identify those who experience an early progression of their disease. These patients are highly addicted to tobacco, and robust efforts should be undertaken to include them in smoking cessation programs. ClinicalTrials.gov: No: NCT01225601 .
ISSN: 1750-1172

hal-01146047
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01146047
PUBMED : 25887097
DOI : 10.1186/s13023-015-0249-2

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
UNLABELLED: ABSTRACT: BACKGROUND: Evidence of a dose-response relationship between prenatal exposure to methylmercury (MeHg) and neurodevelopmental consequences in terms of IQ reduction, makes it possible to evaluate the economic consequences of MeHg exposures. OBJECTIVE: To perform an economic evaluation of annual national benefits of reduction of the prenatal MeHg exposure in France. METHODS: We used data on hair-Hg concentrations in French women of childbearing age (18-45 years) from a national sample of 126 women and from two studies conducted in coastal regions (n = 161and n = 503). A linear dose response function with a slope of 0.465 IQ point reduction per μg/g increase in hair-Hg concentration was used, along with a log transformation of the exposure scale, where a doubling of exposure was associated with a loss of 1.5 IQ points. The costs calculations utilized an updated estimate of €2008 17,363 per IQ point decrement, with three hypothetical exposure cut-off points (hair-Hg of 0.58, 1.0, and 2.5 μg/g). RESULTS: Because of higher exposure levels of women in coastal communities, the annual economic impacts based on these data were greater than those using the national data, i.e. € 1.62 billion (national), and € 3.02 billion and € 2.51 billion (regional), respectively, with the linear model, and € 5.46 billion (national), and € 9.13 billion and € 8.17 billion (regional), with the log model, for exposures above 0.58 μg/g. CONCLUSIONS: These results emphasize that efforts to reduce MeHg exposures would have high social benefits by preventing the serious and lifelong consequences of neurodevelopmental deficits in children.
ISSN: 1476-069X

inserm-00769338
http://www.hal.inserm.fr/inserm-00769338
http://www.hal.inserm.fr/inserm-00769338/document
http://www.hal.inserm.fr/inserm-00769338/file/1476-069X-11-53.pdf
DOI : 10.1186/1476-069X-11-53

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
Advances in groundwater storage monitoring are crucial for water resource management and hydrological processes understanding. The evaluation of water storage changes (WSC) often involve point measurements (observation wells, moisture probes, etc.), which may be inappropriate in heterogeneous media. Over the past few years, there has been an increasing interest in the use of gravimetry for hydrological studies. In the framework of the GHYRAF (Gravity and Hydrology inAfrica) project, 3 yr of repeated absolute gravity measurements using a FG5-type gravimeter have been undertaken at Nalohou, a Sudanian site in northern Benin. Hydrological data are collected within the long-term observing system AMMA-Catch. Once corrected for solid earth tides, ocean loading, air pressure effects, polar motion contribution and non-local hydrology, seasonal gravity variations reach up to 11 μGal, equivalent to a WSC of 260-mm thick infinite layer of water. Absolute temporal gravity data are compared to WSC deduced from neutron probe and water-table variations through a direct modelling approach. First, we use neutronic measurements available for the whole vertical profile where WSC occur (the vadose zone and a shallow unconfined aquifer). The RMSD between observed and modelled gravity variations is 1.61 μGal, which falls within the error bars of the absolute gravity data. Second, to acknowledge for the spatial variability of aquifer properties, we use a 2-D model for specific yield (Sy) derived from resistivity mapping and Magnetic Resonance Soundings (MRS). The latter provides a water content (θMRS) known to be higher than the specific yield. Hence, we scaled the 2-D model of θMRS with a single factor (α). WSC are calculated from water-table monitoring in the aquifer layer and neutronic measurements in the vadose layer. The value of α is obtained with aMonte-Carlo sampling approach, minimizing the RMSD between modelled and observed gravity variations. This leads to α = Sy/θMRS = 0.63 ± 0.15, close to what is found in the literature on the basis of pumping tests experiments, with a RMSD value of 0.94 μGal. This hydrogeophysical experiment is a first step towards the use of time-lapse gravity data as an integrative tool to monitor interannual WSC even in complicated subsurface distribution.
ISSN: 0956-540X

hal-00821181
https://hal.archives-ouvertes.fr/hal-00821181
DOI : 10.1093/gji/ggt146

Résumé : By looking at the common thread between 4 programs* in which the IFREMER Palavas (34, Languedoc-Roussillon region in France) station took part, this report show the evolution over 20 years in the perception of the pathology of farmed fish, and of the sea bass in particular (Dicentrarchus labrax). During the 1990’s farming techniques became sufficiently reliable to enable to distinguish between problems of a zootechnical nature and those with a pathological origin. In anticipation of future illnesses, the necessary tools and monitoring were implemented in order to study the immune system of the sea bass. These methods arose from the recent creation of anti-immunoglobin monoclonal probes in the sea bass. These techniques, together with others, served to search for a solution to the nodavirus epidemic which struck in1996. In the absence of a cure for this virus, the research focused on knowledge of the virus, its epidemiology and vaccine development. Despite interesting scientific results, the solution withheld to curb the Nodavirus epidemic was zootechnical. This pragmatic outcome catalysed reflections on the role of pathology, leading to notions of health, animal well-being and image. Management choices in the health of farmed fish stocks became a parameter, amongst others, included in a global commercial and farming policy. * Définition des critères d’évaluation de l’immunocompétente chez le loup et le turbot. UMR1 Université Montpellier II IFREMER ; Nodavirus disease of cultured marine fish in Europe. FAIR PL98 4036 EU; Recherche de moyens de dépistage et prévention de la nodavirose du bar. ANVAR 9804041J ; Welfare and Health in Sustainable Aquaculture WEALTH. E.U N°501984.
En prenant comme fil conducteur les travaux de 4 programmes* auxquels a participé la station IFREMER de Palavas (34), ce rapport montre l’évolution sur 20 ans de la perception de la pathologie des poissons d’élevages et du loup en particulier (Dicentrarchus labrax). Dans les années 1990 les techniques d’élevages devinrent suffisamment fiables pour permettre de distinguer les problèmes d’origines zootechniques de ceux d’origines pathologiques. En prévision des futures maladies potentielles, les outils d’étude et de suivi du système immunitaire spécifique du loup furent mis en place. Ils découlaient de la création récente de sondes monoclonales anti-immunoglobulines de loup. Ces techniques, couplées à d’autres, servirent à chercher une solution à l’épidémie de nodavirose des années 1996. En l’absence de traitement pour un virus l’accent fut mis sur la connaissance du virus, de son épidémiologie et de la vaccination. Bien que les résultats scientifiques furent très satisfaisants la solution trouvée pour juguler l’épidémie de Nodavirose fut zootechnique. Cette issue pragmatique catalysa une réflexion sur le rôle de la pathologie qui maturait depuis plusieurs années et qui déboucha sur la notion de santé, de bien être des animaux et d’image. Les choix de gestion de la santé des cheptels devinrent un paramètre, parmi d’autres, s’incluant dans d’une politique globale d’élevage et commerciale * Définition des critères d’évaluation de l’immunocompétente chez le loup et le turbot. UMR1 Université Montpellier II IFREMER ; Nodavirus disease of cultured marine fish in Europe. FAIR PL98 4036 EU; Recherche de moyens de dépistage et prévention de la nodavirose du bar. ANVAR 9804041J ; Welfare and Health in Sustainable Aquaculture WEALTH. E.U N°501984.

Droits : 2013 Ifremer
http://archimer.ifremer.fr/doc/00167/27866/26103.pdf
http://archimer.ifremer.fr/doc/00167/27866/26105.pdf
http://archimer.ifremer.fr/doc/00167/27866/26106.pdf
http://archimer.ifremer.fr/doc/00167/27866/

Éditeur(s) : HAL CCSD Publisher : Paris : Baillière [1980-. Latest Publisher : Paris : Elsevier
Résumé : National audience
Introduction L’atteinte œsophagienne est fréquente chez les patients présentant une sclérodermie systémique. Le diagnostic est confirmé par la manométrie œsophagienne. La sensibilité et la spécificité de la manométrie œsophagienne ont été améliorées par l’avènement de la manométrie de haute résolution. L’objectif principal de cette étude observationnelle est de caractériser les troubles moteurs œsophagiens par manométrie de haute résolution, à la lumière de la troisième version de la classification de Chicago, chez des patients présentant une sclérodermie systémique selon les critères de l’EULAR/ACR 2013. Patients et méthodes Trente-six patients répondant au diagnostic de sclérodermie systémique selon les critères EULAR/ACR 2013 et ayant bénéficié d’une manométrie de haute résolution dans un centre de compétence français ont été inclus de manière consécutive. Les résultats de la manométrie de haute résolution ont été interprétés selon la troisième version de la classification de Chicago. Les caractéristiques cliniques, biologiques et les atteintes viscérales des patients ont également été relevées et confrontées aux données manométriques. L’atteinte pulmonaire était évaluée selon la méthode de Goh et al. en aveugle des données manométriques. Résultats L’âge moyen à l’inclusion était de 58,4 ans (SD = 14,2 ans) ; 83,3 % des patients étaient de sexe féminin. 22,2 % des patients avaient une sclérodermie systémique avec atteinte cutanée diffuse selon la classification de LeRoy ; 67 % des patients avaient un pyrosis, 30,6 % une dysphagie, 33,3 % une dyspepsie. 11 % des patients avaient des épisodes de fausses routes. D’après les résultats de la manométrie de haute résolution, 55,6 % des patients avaient un apéristaltisme, 33,3 % une hypotonie du sphincter inférieur de l’œsophage et 19,4 % une hypotonie du sphincter supérieur de l’œsophage. En analyse univariée, il n’était pas retrouvé d’association significative entre la présence d’une hypotonie du sphincter inférieur de l’œsophage et les caractéristiques cliniques ou biologiques quelles qu’elles soient. La présence d’un apéristaltisme était associée avec une symptomatologie de pyrosis (p = 0,004). L’apéristaltisme était associé de manière significative avec la présence de télangiectasies (p = 0,007) et d’anticorps anti-centromères (p = 0,038). La présence de calcinose ou d’une sclérodactylie n’était pas spécifiquement associée à une atteinte sphinctérienne ou motrice œsophagienne. Vingt-neuf patients (80,6 %) avaient bénéficié d’une TDM thoracique dans l’année de la réalisation de la manométrie de haute résolution. Parmi eux, 7 patients étaient atteints d’une pneumopathie interstitielle diffuse sévère (atteinte interstitielle de plus de 20 % du parenchyme pulmonaire évaluée sur 5 coupes standardisées). Il existait une association significative entre la présence d’un apéristaltisme et la présence d’une dilatation œsophagienne en TDM (p = 0,002) et la présence d’une atteinte pulmonaire sévère (p = 0,005, OR = 6,85 IC95 % (1,12–41,82)). Discussion L’association retrouvée entre apéristaltisme en manométrie de haute résolution et sévérité de la PID est confirmée par ce travail. Néanmoins un lien de causalité n’est pas certain. Une étude prospective évaluant la mise en évidence d’une atteinte œsophagienne par manométrie de haute résolution au moment du diagnostic de sclérodermie systémique et l’atteinte pulmonaire par TDM à distance serait nécessaire. L’entité nosologique représentée par le syndrome CREST n’est pas retrouvée dans cette cohorte de patients atteints de sclérodermie systémique selon les critères EULAR/ACR 2013, où 2 des critères diagnostiques (présence de calcinose et sclérodactylie) ne sont pas associés de manière significative à l’atteinte œsophagienne d’après les résultats de la manométrie de haute résolution. Conclusions Dans cette série, chez plus de la moitié des patients atteints de sclérodermie systémique la manométrie de haute résolution permet de détecter un apéristaltisme. La présence de troubles moteurs œsophagiens est associée à une atteinte pulmonaire plus sévère en TDM
ISSN: 0248-8663

hal-01321854
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01321854
DOI : 10.1016/j.revmed.2016.04.267

Éditeur(s) : HAL CCSD National Institute of Environmental Health Sciences (NIEHS) National Institute of Environmental Health Sciences
Résumé : International audience
Long-term exposure to persistent pollutants with hormonal properties (endocrine-disrupting chemicals, EDCs) may contribute to the risk of prostate cancer (PCa). However, epidemiological evidence remains limited. We investigated the relationship between PCa and plasma concentrations of universally widespread pollutants, in particular p,p'-dichlorodiphenyl dichloroethene (DDE) and the non-dioxin like polychlorinated biphenyl congener 153 (PCB153). We evaluated before treatment 576 men with newly diagnosed PCa and 655 controls in Guadeloupe (French West Indies). Exposure was analyzed according to case-control status. Associations were assessed by unconditional logistic regression analysis, controlling for confounding factors. Missing data were handled by multiple imputation. We estimated a significant positive association between DDE and PCa (adjusted odds ratio [OR] 1.53; 95% CI 1.02, 2.30 for the highest versus lowest quintile of exposure; PTrend = 0.01). PCB153 was inversely associated with PCa (OR 0.30; 95% CI 0.19, 0.47 for the highest versus lowest quintile of exposure values; PTrend < 0.001). Also, PCB153 was more strongly associated to low-grade than high grade PCa. Associations of PCa with DDE and PCB153 were in opposite directions. This may reflect differences in the mechanisms of action of these EDCs, and although our findings need to be replicated in other populations, they are consistent with complex effects of EDCs on human health.
ISSN: 0091-6765

hal-01118553
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118553
DOI : 10.1289/ehp.1408407
PUBMED : 25493337

Éditeur(s) : HAL CCSD Wiley
Résumé :  
Evaluating the genetic architecture of sexual dimorphism can aid our understanding of the extent to which shared genetic control of trait variation versus sex-specific control impacts the evolutionary dynamics of phenotypic change within each sex. We performed a QTL analysis on Silene latifolia to evaluate the contribution of sex-specific QTL to phenotypic variation in 46 traits, whether traits involved in trade-offs had colocalized QTL, and whether the distribution of sex-specific loci can explain differences between the sexes in their variance/covariance matrices. We used a backcross generation derived from two artificial-selection lines. We found that sex-specific QTL explained a significantly greater percent of the variation in sexually dimorphic traits than loci expressed in both sexes. Genetically correlated traits often had colocalized QTL, whose signs were in the expected direction. Lastly, traits with different genetic correlations within the sexes displayed a disproportionately high number of sex-specific QTL, and more QTL co-occurred in males than females, suggesting greater trait integration. These results show that sex differences in QTL patterns are congruent with theory on the resolution of sexual conflict and differences based on G-matrix results. They also suggest that trade-offs and trait integration are likely to affect males more than females.
ISSN: 0014-3820

hal-01032136
https://hal.archives-ouvertes.fr/hal-01032136
DOI : 10.1111/j.1558-5646.2010.01048.x

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Benzo[a]pyrene (B[a]P), the prototype molecule of polycyclic aromatic hydrocarbons, exhibits genotoxic and carcinogenic effects, which has led the International Agency for Research on Cancer to recognize it as a human carcinogen. Besides the well-known apoptotic signals triggered by B[a]P, survival signals have also been suggested to occur, both signals likely involved in cancer promotion. Our previous work showed that B[a]P induced an hyperpolarization of mitochondrial membrane potential (ΔΨm) in rat hepatic epithelial F258 cells. Elevated ΔΨm plays a role in tumor development and progression, and nitric oxide (NO) has been suggested to be responsible for increases in ΔΨm. The present study therefore aimed at evaluating the impact of B[a]P on NO level in F258 cells, and at testing the putative role for NO as a survival signal, notably in link with ΔΨm. Our data demonstrated that B[a]P exposure resulted in an NO production which was dependent upon the activation of the inducible NO synthase. This enzyme activation involved AhR and possibly p53 activation. Preventing NO production not only increased B[a]P-induced cell death but also blocked mitochondrial hyperpolarization. This therefore points to a role for NO as a survival signal upon B[a]P exposure, possibly targeting ΔΨm
ISSN: 0887-2333

hal-01163757
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01163757
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01163757/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01163757/file/Benzo%5Ba%5Dpyrene-induced%20nitric.pdf
DOI : 10.1016/j.tiv.2015.06.010

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
This study aimed to compare the relative survival of patients with invasive breast cancer between women from French Guiana (a French territory in South America) and metropolitan France. No study hadever compared survival of breast cancer on the basis of immigrant status in France. Our study underlined that access to care for migrants is challenging whichwgenerates health inequalities. Background The prognosis of breast cancer in French Guiana is worse than in France with 23 deaths per 100 incident cases against 17 per 100 in metropolitan France. This study aimed to compare relative survival of patients with invasive breast cancer (IBC) between women from French Guiana and metropolitan France and to determine risk factors influencing breast cancer survival in French Guiana.Materials and methods Data were collected from the Cancer registry of French Guiana. We comparedthe relative survival of women with IBC between French Guiana and metropolitan France. We used Cox's proportional hazard regression to evaluate the effect of prognostic factors on cancer-specific mortality in French Guiana. Results We included all 269 cases of IBC in women diagnosed in French Guiana between 2003 and 2009. The overall 5-year relative survival rate of patients with IBC was 79% in French Guiana and 86% in metropolitan France. The place of birth (foreign country versus French territory), the tumor stage at the time of diagnosis, the mode of diagnosis (symptoms versus screening), the presence of hormone receptors in the tumor and the histologic type were the variables associated with survival differences. None of the other study variables were significantly associated with prognosis. Conclusion Access to care for migrants is challenging,which leads to health inequalities. Early detection through prevention programs is crucial to increaseIBC survival notably for foreign-born patients.
ISSN: 1526-8209

hal-01288657
https://hal.archives-ouvertes.fr/hal-01288657
https://hal.archives-ouvertes.fr/hal-01288657/document
https://hal.archives-ouvertes.fr/hal-01288657/file/2016%2C%20Roue%20-%20Predictive%20factors%20of%20the%20survival%20of%20women%20with%20invasive%20breast%20cancer%20in%20French%20Guiana.pdf

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
We report new data on the geochemical evolution, metasomatic and deformation processes in the lower layers of cratonic lithospheric mantle based on a detailed study of extraordinarily fresh and large deformed peridotite xenoliths from the Udachnaya kimberlite pipe, Siberia. Based on our T-P estimates, the deformed peridotites are localized in a depth range of 170 to 220 km near the base of cratonic mantle. The degree of deformation is not correlated with the depth and equilibration temperatures of the xenoliths. The deformed peridotites are depleted in magmaphile major elements indicating their residual nature, but are enriched in incompatible trace elements, Fe and K. The deformed peridotites experienced a complex evolution, i.e., they were formed initially as high-degree melt extraction residues and later were subjected to three main stages of metasomatic modification. (1) An old, mostly cryptic metasomatism by melt/fluid of carbonatitic composition, which formed garnets with sinusoidal REE patterns (Smn/Ern > 1). (2) Silicate metasomatism, which led to the most significant changes in mineralogical and chemical composition of the deformed peridotites. (3) Fe and Ti metasomatism just before the entrainment of the deformed rocks into kimberlite magma. Enrichment of the peridotites in large-ion lithophile elements (K, Rb, Ba) is related to the formation of kelyphitic rims around garnet. The nature of the metasomatic agent of silicate metasomatism was evaluated from mass-balance of measured and calculated whole-rock compositions, ratios of highly incompatible elements (D < 0.1) and fractional crystallization modeling. All this evidence indicates that the agent of silicate metasomatism had a composition intermediate between that of kimberlites and HIMU OIB. The metasomatic processes responsible for the formation of deformed peridotites and precipitation of megacryst suites cannot be widespread at the base of the cratonic mantle. Rather, they are local features only existing in the cratonic mantle below kimberlite fields and localized along the metasomatic vein system.
ISSN: 0024-4937

hal-00941010
https://hal.archives-ouvertes.fr/hal-00941010
DOI : 10.1016/j.lithos.2012.11.014

Éditeur(s) : HAL CCSD
Résumé : International audience
The mathematical site of an exercise or a theorem is a useful tool which helps to organize its study, by putting into a hierarchy the various elements (substratum, objects, techniques, technologies) relevant to describe its ecosystem. These characteristics of the mathematical site turn it into a help for the pupil or student (within the framework of an evaluation in mathematics), what we show by the analysis in term of site of a subject given in the competitive ex-amination for secondary school teaching (CAPES) in mathematics. Furthermore, by revealing the organization of a mathematical concept, we show that the site can be a tool for professional training of teachers of mathematics, on the example of the characterization of a constant function on an interval by its derivative.
Le site mathématique local d’un énoncé d’exercice ou d’un théorème de cours se compose d’un système d’êtres mathématiques (objets, techniques, technologies…) et de relations, enrichis par un substrat, formé d’éléments non mathématisables dans l’institution considérée, dévoilant l’organisation de la question. Ces caractéristiques font que le site local fonctionne comme un écosystème, permettant la compréhension d’activités mathématiques de classe, d’évaluation, ce que nous montrons par l’analyse d’un dossier d’oral 2 du CAPES externe de mathématiques. Ce faisant, il devient un outil du professeur pour guider les élèves dans l’étude d’une question. De plus, comme il révèle les organisations locales en mathématiques, le site peut être utilisé comme un outil de formation professionnelle d’enseignants. Par exemple, il permet de questionner les progressions scolaires ou universitaires reçues, ce que nous discutons sur le cas de la caractérisation d’une fonction constante sur un intervalle par sa dérivée.
Repères IREM

hal-01530861
https://hal.univ-antilles.fr/hal-01530861

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
We carried out morphotectonic studies along the left-lateral strike-slip Bogd Fault, the principal structure involved in the Gobi-Altay earthquake of 1957 December 4 (published magnitudes range from 7.8 to 8.3). The Bogd Fault is 260 km long and can be subdivided into five main geometric segments, based on variation in strike direction. West to East these segments are, respectively: the West Ih Bogd (WIB), The North Ih Bogd (NIB), the West Ih Bogd (WIB), the West Baga Bogd (WBB) and the East Baga Bogd (EBB) segments. Morphological analysis of offset streams, ridges and alluvial fans-particularly well preserved in the arid environment of the Gobi region-allows evaluation of late Quaternary slip rates along the different faults segments. In this paper, we measure slip rates over the past 200 ka at four sites distributed across the three western segments of the Bogd Fault. Our results show that the left-lateral slip rate is similar to 1 mm yr(-1) along the WIB and EIB segments and similar to 0.5 mm yr(-1) along the NIB segment. These variations are consistent with the restraining bend geometry of the Bogd Fault.;Our study also provides additional estimates of the horizontal offset associated with the 1957 earthquake along the western part of the Bogd rupture, complementing previously published studies. We show that the mean horizontal offset associated with the 1957 earthquake decreases progressively from 5.2 m in the west to 2.0 m in the east, reflecting the progressive change of kinematic style from pure left-lateral strike-slip faulting to left-lateral-reverse faulting. Along the three western segments, we measure cumulative displacements that are multiples of the 1957 coseismic offset, which may be consistent with a characteristic slip. Moreover, using these data, we re-estimate the moment magnitude of the Gobi-Altay earthquake at M-w 7.78-7.95.;Combining our slip rate estimates and the slip distribution per event we also determined a mean recurrence interval of similar to 2500-5200 yr for past earthquakes along the different segments of the western Bogd Fault. This suggests that the three western segments of the Bogd Fault and the Gurvan Bulag thrust fault (a reverse fault bounding the southern side of the Ih Bogd range that ruptured during the 1957 earthquake) have similar average recurrence times, and therefore may have ruptured together in previous earthquakes as they did in 1957. These results suggest that the western part of the Bogd Fault system, including the Gurvan Bulag thrust fault, usually behaves in a 'characteristic earthquake' mode.
ISSN: 0956-540X

hal-00639467
https://hal.archives-ouvertes.fr/hal-00639467
https://hal.archives-ouvertes.fr/hal-00639467v2/document
https://hal.archives-ouvertes.fr/hal-00639467/file/rizzaGJI2011.pdf
DOI : 10.1111/j.1365-246X.2011.05075.x

Éditeur(s) : HAL CCSD SAGE Publications
Résumé : International audience
: French Guiana is the French territory that is most affected by HIV. AIDS incidence is much higher than in mainland France and sex work seems to be an important driver of the epidemic. The objective of this study was to describe consistent condom use among female sex workers with their clients and their intimate partners and to identify determinants of non-use of condoms. An HIV/AIDS Knowledge, Attitudes, Behaviours and Practices survey was conducted in 2009-2010 among sex workers in French Guiana. A total of 477 sex workers were interviewed. Female sex workers were more likely to use condoms with their clients (97%) than with their intimate partners (45%). The factors associated with non-consistent condom use with the intimate partner were having had an abortion, feeling at risk for HIV, not evaluating one's own risk for HIV, living as a couple, being Dominican, not feeling comfortable asking intimate partners to use condoms. Although a high proportion of female sex workers declared using condoms with commercial partners, there is still room for improvement in the prevention of transmission with both commercial and intimate partners.
ISSN: 0956-4624

inserm-01065111
http://www.hal.inserm.fr/inserm-01065111
http://www.hal.inserm.fr/inserm-01065111/document
http://www.hal.inserm.fr/inserm-01065111/file/Table_III_IJSA.pdf
http://www.hal.inserm.fr/inserm-01065111/file/2014_Parriault_-_Predictive_factorssur unprotected_sex_for_female_sex_workers.pdf

Éditeur(s) : HAL CCSD Geological Society of America
Résumé : International audience
In this study, a novel application of a statistical approach is utilized for analysis of downhole logging data from Miocene-aged siliciclastic shelf sediments on the New Jersey Margin (eastern USA). A multivariate iterative nonhierarchical cluster analysis (INCA) of spectral gamma-ray logs from Integrated Ocean Drilling Program (IODP) Expedition 313 enables lithology within this siliciclastic succession to be inferred and, through comparison with the 1311 m of recovered core, a continuous assessment of depositional sequences is constructed. Signifi cant changes in INCA clusters corroborate most key stratigraphic surfaces interpreted from the core, and this result has particular value for surface recognition in intervals of poor core recovery. This analysis contributes to the evaluation of sequence stratigraphic models of large-scale clinoform complexes that predict depositional environments, sediment composition, and stratal geometries in response to sea-level changes. The novel approach of combining statistical analysis with detailed lithostratigraphic and seismic refl ection data sets will be of interest to any scientists working with downhole logs, especially spectral gamma-ray data, and also provides a reference for the strengths and weaknesses of multi component analysis applied to continental margin lithofacies. The method presented here is appropriate for evaluating successions elsewhere and also has value for hydrocarbon exploration where sequence stratigraphy is a fundamental tool.
EISSN: 1553-040X

insu-00858238
https://hal-insu.archives-ouvertes.fr/insu-00858238
DOI : 10.1130/GES00913.1

Éditeur(s) : HAL CCSD
Résumé : International audience
This paper examines the historical signatures of 18th century composer, J. S. Bach, to evaluate the effects of vision impairment on handwritten signatures. It is questioned whether Bach penned certain signatures as it is historically documented that he was virtually blind in the years just prior to his death in 1750. Applying information collected from published forensic studies about the effects of vision impairment on handwriting, handwriting indices of vision impairment are compared to Bach's signatures in the late 1740s.
17th Biennial Conference of the International Graphonomics Society
Pointe-à-Pitre, Guadeloupe

hal-01165902
https://hal.univ-antilles.fr/hal-01165902
https://hal.univ-antilles.fr/hal-01165902/document
https://hal.univ-antilles.fr/hal-01165902/file/IGS_2015_submission_25.pdf

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Sexually transmitted viruses infect the genital and colorectal mucosa of the partner exposed to contaminated genital secretions through a wide range of mechanisms, dictated in part by the organization of the mucosa. Because understanding the modes of entry into the organism of viruses transmitted through sexual intercourse is a necessary prerequisite to the design of treatments to block those infections, in vitro modeling of the transmission is essential. The aim of this review is to present the models and methodologies available for the in vitro study of the interactions between viruses and mucosal tissue and for the preclinical evaluation of antiviral compounds, and to point out their advantages and limitations according to the question being studied.
ISSN: 0042-6822

Droits : http://creativecommons.org/licenses/by/
hal-01663650
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01663650
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01663650/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01663650/file/Frouard%20-%20In%20vitro%20models%20for%20deciphering.pdf
DOI : 10.1016/j.virol.2017.11.023