Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Fault friction is a parameter that is difficult to assess along fault zones since its determination depends on the knowledge of any factor controlling the state of stress around faults. In brittle homogeneous rocks, a limited number of these factors, such as the shape of the fault surface, the vicinity of fault tips or the remote stress ratio, are crucial to constrain for this determination. In this paper, we propose to analyse a field example in which all these properties are met and where the nature of the slipped structure suggest differences in static friction. We compare the orientations of branching fractures at strike-slip relay zones between en echelon stylolites and en echelon joints both reactivated in shear. The field data are compared with both photoelastic and 3-D numerical models that consider the remote stress conditions and the role of the geometry of the strike-slip segments. Based on field observations, these analyses quantitatively demonstrate the significant role of fault friction on the local stress field orientation and subsequent fracture formation. This work points out that estimations of fault friction based on analyses of fracture patterns or in situ stresses must be accompanied with a thorough investigation of the 3-D fault shape, its segmentation and the remote stress state.
ISSN: 0191-8141

hal-00560999
https://hal.archives-ouvertes.fr/hal-00560999
DOI : 10.1016/j.jsg.2010.01.008

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
Electrical resistivity soundings are used by geophysicists to determine the structure and composition of the Earth's crust and mantle and to explore natural resources (ore, oil, gas, water). Their interpretations in terms of composition and in-situ physical conditions depend mainly on laboratory measurements of electrical conductivity of rocks at simulated crustal conditions of temperature, pressure, saturation and pore pressures. These measurements present a numbers of limitations, in particular, in the case where conductive pore fluids are present, as in the case of deep reservoir conditions, where temperature exceeds 250 A degrees C. Here, we present a new cell capable of measuring electrical conductivity of large saturated samples at confining pressure up to 200 MPa, pore pressure up to 50 MPa, and temperature up to 500 A degrees C. The measurement cell has been developed in a commercial, internally heated, gas pressure apparatus (Paterson press). It is based on the concept of "guard ring" electrode, which is adapted to samples that are jacketed by a very conductive, metallic material. Numerical modeling of the current flow in the electrical cell allowed defining the optimal cell geometry. Calibration tests have been performed on Fontainebleau sandstones saturated with electrolytes of different conductivities, up to 350 A degrees C. The resulting electrical formation factor and temperature dependence of electrical conductivity are in very good agreement with previous studies. This new cell will improve the exploration and exploitation of deep fluid reservoirs, as in unconventional, high enthalpy geothermal fields. In particular, the investigations address possible effects of fluid-rock interactions on electrical resistivity of a reservoir host rock.
ISSN: 0169-3913

hal-00681997
https://hal.archives-ouvertes.fr/hal-00681997
DOI : 10.1007/s11242-011-9846-2

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The estrogen receptor (ER) is a transcription factor that binds under 17-b-estradiol (E2) stimulation as homodimer to a short DNA consensus sequence named estrogen response element (ERE). The ER/ERE interaction has been assessed by several research groups through different methodologies notably by surface plasmon resonance (SPR) techniques. The biochemical parameters and conditions (solvent, ER concentration, salt, time and temperature) used to prepare samples before analysis were very different from one study to another. But no studies have aimed to compare the effect of these modifications on ER/ERE interaction. Therefore the main objective of the present paper was to assess the influence of biochemical parameters onto the ER/ERE interaction with the final aim to improve the comprehension of this interaction. Our results highlighted that parameters like solvent, ER concentration, salt and surfactant concentration, temperature and time deeply modify ER/ERE interaction. Nevertheless, the dimer formation under E2 stimulation occurred with all tested conditions. Altogether, incubation parameters of ER with E2, deeply modify its binding level onto ERE. These data constitute an important key point to consider for the improvement of ER/ERE detection method depending upon the aim of the study (interaction measurement, environmental detection, development of new technologies or devices).
ISSN: 0003-9861

hal-00936061
https://hal.archives-ouvertes.fr/hal-00936061
https://hal.archives-ouvertes.fr/hal-00936061/document
https://hal.archives-ouvertes.fr/hal-00936061/file/Impactsur biochemical_design_on_estrogen_receptor_estrogen_response_element_interaction_by_surface_plasmon_resonance_technology-accepted.pdf
DOI : 10.1016/j.abb.2013.11.006

Éditeur(s) : HAL CCSD
Résumé : Visceral leishmaniasis is a life-threatening systemic disease caused by Leishmania protozoans, L. donovani and L. infantum, which invade mononuclear phagocytes in the lymphoid organs and the liver. The control of the hepatic parasite burden depends on the granuloma formation, which is favored by a Th1 immune response in a Th2 tissue microenvironment. The aim of this work was to study the role of the recently described Th2 cytokine IL-33 in this complex immune response, which remains partially misunderstood. IL-33 dosages in different patient sera and IL-33+ cells detected in the liver of a patient from Rennes suggested that IL-33 could be a biomarker for active visceral leishmaniasis. As IL-33 was described in hepatic stellate cells during chronic hepatitis, these cells were exposed to L. donovani in primary culture. The cell permissivity to L. donovani and the parasite persistence during a long term culture led us to propose hepatic stellate cells as a new type of sanctuary cells, which could partially explain asymptomatic carriage. However, these cells were apparently not the main source of IL-33 during visceral leishmaniasis. In infected BALB/c and C57BL/6 mice, IL-33 was detected in the liver in non stellate cells preferentially localized in granulomas. The presence of cells expressing its specific receptor ST2 in the liver led us to explore the role of the IL-33/ST2 axis. BALB/c mice deficient in ST2 or treated with recombinant IL-33 and infected with L. donovani revealed that IL-33 downregulates the expression of Th1 key cytokines (IL-12, IFN-γ) and the recruitment of neutrophils and monocytes. Finally, IL-33 acts as a susceptibility factor during visceral leishmaniasis. Besides, the model of L. donovani infected C57BL/6 mice deficient in IL-33 or treated with recombinant IL-33 suggests possible differential roles of IL-33 depending on the immune environment related to the host genetic background.
La leishmaniose viscérale est une maladie systémique mortelle en l’absence de traitement. Elle est due aux protozoaires Leishmania donovani et L. infantum, parasites des phagocytes mononucléés, capables d’envahir les organes lymphoïdes et le foie. Le contrôle de l’infection hépatique repose sur la mise en place d’une réponse granulomateuse efficace, promue par une réponse immunitaire Th1, dans un environnement tissulaire Th2. L’objectif de ce travail était l'étude du rôle d’une cytokine Th2 récemment décrite, l’IL-33, dans cette réponse hépatique complexe encore partiellement incomprise. Des dosages d’IL-33 sur des sérums de patients et la détection de cellules IL-33+ dans le foie d’un patient rennais ont placé l’IL-33 comme un biomarqueur possible de la maladie active. L’IL-33 étant exprimée dans les cellules étoilées du foie au cours d’hépatites chroniques, ces cellules ont été exposées à L. donovani. Leur permissivité aux leishmanies sans toxicité apparente ni perturbation de leurs propriétés fonctionnelles, ainsi que la persistance des leishmanies sur une culture de plusieurs semaines, nous ont conduit à proposer les cellules étoilées comme cellules sanctuaires possibles pour les leishmanies viscérotropes, contribuant donc potentiellement au portage asymptomatique. En revanche, elles ne sont pas apparues comme une source majeure d'IL-33 au cours de la leishmaniose viscérale. Chez des souris C57BL/6 et BALB/c infectées par L. donovani, l'IL-33 a été observée dans des cellules ne s'apparentant pas à des cellules étoilées, et principalement localisées dans les granulomes. Des cellules exprimant son récepteur ST2 ayant été également observées dans le foie, un rôle de l’axe IL-33/ST2 a été recherché. Les résultats obtenus chez des souris BALB/c déficientes en ST2 ou traitées par de l'IL-33 recombinante suggèrent que l'IL-33 régule négativement l'expression de cytokines Th1 (IL-12, IFN-γ) et l'infiltrat de neutrophiles et monocytes dans le foie, limitant ainsi le contrôle de la charge parasitaire. Ainsi, l'IL-33 semble être un facteur de susceptibilité pour la leishmaniose viscérale. En parallèle, des travaux entrepris sur des souris C57BL/6 infectées par L. donovani suggèrent de possibles rôles différentiels de l'IL-33 en fonction de l'environnement immunitaire inhérent au fond génétique de l'hôte.
https://tel.archives-ouvertes.fr/tel-01126847

Droits : info:eu-repo/semantics/OpenAccess
NNT : 2013REN1B002
tel-01126847
https://tel.archives-ouvertes.fr/tel-01126847
https://tel.archives-ouvertes.fr/tel-01126847/document
https://tel.archives-ouvertes.fr/tel-01126847/file/2013REN1B002.pdf

Résumé : Édouard Glissant et Ernesto Sábato sont connus pour être a la fois des romanciers et des penseurs. Leur réflexion théorique qui porte principalement sur la langue, l’histoire et l’identité nourrit leur production romanesque et y trouve son lieu d’expression privilégie. Notre travail va porter essentiellement sur l’analyse des œuvres romanesques afin de mettre en relief les procèdes d’écriture tout en faisant référence aux écrits théoriques. En effet, le roman est l’un des lieux ou sont mis en œuvre les principes theoriques élaborés dans les essais, mais le roman constitue aussi un laboratoire d’écriture. Le questionnement sur la forme littéraire la plus apte a contenir l’idéologie des deux romanciers, qui sont a leur manière des écrivains engagés, est narrativise au sein de la fiction. L’analyse des stratégies discursives employées par les deux auteurs nous amènera vers des considérations sur le rôle de l’écrivain dans le processus de fondation d’une conscience nationale de son peuple.
Édouard Glissant and Ernesto Sábato are both well-known for their work as writers and philosophers. Their theoretical reflection, which analyses questions pertaining to language, history and identity, nourishes their novelistic production. In fact their novels mark the crossroads of theory and fiction. The latter are a forum for thought where the theoretical bases of their reflection are applied to reality. This perception of the novel as strictly related to their essay work leads us to consider the use of metafiction, a technique that encompasses both types of creation. The search for different metafiction strategies will allow us to analyze the construction of “guiding fictions”. At the same time, it will lead us to consider the role of a writer in the process of constructing a “national conscience” through literature.

http://www.theses.fr/2014AGUY0742/document

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
BACKGROUND: The TGF-β transforming growth factor is the most pleiotropic cytokine controlling a broad range of cellular responses that include proliferation, differentiation and apoptosis. The context-dependent multifunctional nature of TGF-β is associated with complex signaling pathways. Differential models describe the dynamics of the TGF-β canonical pathway, but modeling the non-canonical networks constitutes a major challenge. Here, we propose a qualitative approach to explore all TGF-β-dependent signaling pathways. RESULTS: Using a new formalism, CADBIOM, which is based on guarded transitions and includes temporal parameters, we have built the first discrete model of TGF-β signaling networks by automatically integrating the 137 human signaling maps from the Pathway Interaction Database into a single unified dynamic model. Temporal property-checking analyses of 15934 trajectories that regulate 145 TGF-β target genes reveal the association of specific pathways with distinct biological processes. We identify 31 different combinations of TGF-β with other extracellular stimuli involved in non-canonical TGF-β pathways that regulate specific gene networks. Extensive analysis of gene expression data further demonstrates that genes sharing CADBIOM trajectories tend to be co-regulated. CONCLUSIONS: As applied here to TGF-β signaling, CADBIOM allows, for the first time, a full integration of highly complex signaling pathways into dynamic models that permit to explore cell responses to complex microenvironment stimuli.
ISSN: 1752-0509

inserm-00978313
http://www.hal.inserm.fr/inserm-00978313
http://www.hal.inserm.fr/inserm-00978313/document
http://www.hal.inserm.fr/inserm-00978313/file/1752-0509-8-30.pdf
DOI : 10.1186/1752-0509-8-30

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The present study aims at better deciphering the different mechanisms involved in the functioning of the subduction interplate. A 2D thermo-mechanical model is used to simulate a subduction channel, made of oceanic crust, free to evolve. Convergence at constant rate is imposed under a 100 km thick upper plate. Pseudo-brittle and non-Newtonian behaviours are modelled. The influence of the subduction channel strength, parameterized by the difference in activation energy between crust and mantle () is investigated to examine in detail the variations in depth of the subduction plane down-dip extent, . First, simulations show that numerical resolution may be responsible for an artificial and significant shallowing of if the weak crustal layer is not correctly resolved. Second, if the age of the subducting plate is 100 Myr, subduction occurs for any . The stiffer the crust is, that is, the lower is, the shallower is (60 km depth if kJ/mol) and the hotter the fore-arc base is. Conversely, imposing a very weak subduction channel ( J/mol) leads there to an extreme mantle wedge cooling and inhibits mantle melting in wet conditions. Partial kinematic coupling at the fore-arc base occurs if kJ/mol. If the incoming plate is 20 Myr old, subduction can occur under the conditions that the crust is either stiff and denser than the mantle, or weak and buoyant. In the latter condition, cold crust plumes rise from the subduction channel and ascend through the upper lithosphere, triggering (1) partial kinematic coupling under the fore-arc, (2) fore-arc lithosphere cooling, and (3) partial or complete hindrance of wet mantle melting. then ranges from 50 to more than 250 km depth and is time-dependent if crust plumes form. Finally, subduction plane dynamics is intimately linked to the regime of subduction-induced corner flow. Two different intervals of are underlined: 80–120 kJ/mol to reproduce the range of slab surface temperature inferred from geothermometry, and 10–40 kJ/mol to reproduce the shallow hot mantle wedge core inferred from conditions of last equilibration of near-primary arc magmas and seismic tomographies. Therefore, an extra process controlling mantle wedge dynamics is needed to satisfy simultaneously the aforementioned observations. A mantle viscosity reduction, by a factor 4–20, caused by metasomatism in the mantle wedge is proposed. From these results, I conclude that the subduction channel down-dip extent, , should depend on the subduction setting, to be consistent with the observed variability of sub-arc depths of the subducting plate surface.
ISSN: 0031-9201

hal-01623155
https://hal.archives-ouvertes.fr/hal-01623155
DOI : 10.1016/j.pepi.2017.05.008

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Improving the prediction of sub-seismic structures and their petrophysical properties is essential for realistic characterization of deformed sandstone reservoirs. In the present paper, we describe permeability contrasts induced by cataclastic deformation bands and faults in porous sandstones (766 data synthesized from field examples and the literature). We also discuss the influence of several factors, including tectonic regime, presence of a fault, burial depth, host sandstone porosity, and grain size and sorting for their initiation and permeability. This analysis confirms that permeability decrease is as a function of grain-crushing intensity in bands. Permeability reduction ranges from very limited in crush-microbreccia of compaction bands to high permeability reduction in cataclasites and ultracataclasites of shear-dominated bands, band clusters and faults. Tectonic regime, and especially normal-fault regime, with its tendency to localize strain and generate faults, is identified as the most important factor, leading to the formation of cataclastic bands with high permeability contrasts. Moreover, moderate burial depth (1–3 km) favors cataclastic bands with high permeability contrasts with respect to the host sandstone. High porosity, coarse-grain size and good grain sorting can slightly amplify the permeability reductions recorded in bands.
ISSN: 0191-8141

hal-01218408
https://hal.archives-ouvertes.fr/hal-01218408
DOI : 10.1016/j.jsg.2015.03.013

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Almost all Red Sea deeps contain metal-rich sediments covered by brine pools. It is generally agreed that these metal-rich deposits precipitated from overlying metal-rich brines that originated from migrating hydrothermal fluids. No brine pool has ever been reported in Thetis Deep, inciting us to evaluate if such a brine layer ever occurred in the deep during the past. In order to address that questioning, a study combining mineralogical, geochemical (major-, minor-, rare-earth elements) and isotopic (Sr. Nd. Pb) approaches was completed on cored sediments and extracted interstitial waters from inside and outside the deep.;The sediments have an overall hydrothermal origin, as shown by the REE concentrations and patterns, metal contents, and Pb-Nd isotopic data, all pointing to a mantle signature. The intensity of the hydrothermal activity varied with time in the deep; the most intense episode resulting in an almost pure Fe-oxi-hydroxide layer. Varied chemical arguments, especially the Zr and REE data of the sediments, favor the fact that the whole sedimentation in Thetis Deep occurred in the absence of a stable, salt-rich and mineralized brine pool, and that no brine layer ever existed. This conclusion is supported by the constant Sr isotope composition of the sediment and its interstitial waters that are almost identical to that of the Red Sea seawater. The study also suggests that hydrothermal activity monitored fluid supplies that interacted differently with seawater in the different Red Sea deeps, resulting in an overall formation of metal-rich sediments, but along varied local conditions. (C) 2009 Elsevier B.V. All rights reserved.
ISSN: 0375-6742

hal-00475646
https://hal.archives-ouvertes.fr/hal-00475646
DOI : 10.1016/j.gexplo.2009.10.001

Éditeur(s) : HAL CCSD Ecole nationale du génie rural
Résumé :  
A l'échelle de l'arbre, la fertilité chimique des sols semble expliquer la localisation majoritairement superficielle du système racinaire, alors que le type de drainage explique la forte variabilité de sa répartition verticale. Les racines profondes, malgré leur faible proportion, jouent un rôle important pour extraire l'eau en saison sèche. A l'échelle du peuplement, les variations latérales du sol influent sur des processus tels que la compétition inter-individuelle et la sylvigénèse. Pour les sols de terre ferme, plus les conditions édaphiques sont contraignantes, plus les gros arbres sont rares dans le peuplement forestier. Celui-ci est dense lorsque le sol est très aminci, moins dense en situation hydromorphe. Le sol influence nettement la composition floristique des peuplements. Mais d'autres facteurs tels la dynamique sylvigénétique ou la dynamique propre à chaque population ont un poids très important. Des résultats divergents conduisent à formuler de nouvelles hypothèses, parmi celles-ci l'influence majeure de l'épaisseur du profil d'altération.
ISSN: 0035-2829

hal-01031882
https://hal.archives-ouvertes.fr/hal-01031882

Résumé : On observe en martinique certains élèves qui entrent et sortent du système secondaire ne maîtrisant pas le langage écrit. cependant certains troubles du langage écrit pourraient provenir d'un manque de repères, de désordre de la « maison intérieure ». des travaux plaçant l'individu dans une perspective constructiviste ont certes déjà été menés en martinique. cependant des travaux mettant l'élève martiniquais au centre de sa culture et considérant cette dernière comme vecteur de compétences écrites et de savoir pourraient être considérés comme un nouveau champ d'investigation. d'après jérôme bruner les récits en forme l'expérience humaine.mes recherches m'amèneront à considérer deux genres de récits : les récits autobiographiques et les contes martiniquais comme des vecteurs de la culture locale et comme des compensateurs de manques au niveau des mémoires cognitives, collectives, culturelles et individuelles. ils pourraient par voie de conséquence devenir des moyens de remédiation aux problèmes liés à l'écrit. je privilégierai comme champ d'observation les adolescents en difficulté entrant en classe de sixième.
The present research deals with cultural psychology. It aims to show how culture can influence the cognitive skills of underachieving students.Before cultural psychology emerged, social constructivism best represented by Piaget and Vygotski, and later in the twentieth century by Jérôme Bruner or Bertrand Troadec underlined the importance of culture in children’s mental dispositions.Their research on influence of culture in children’s cognitive dispositions are used as guiding principle.Over the years, it has been noticed that quite a large number of Martinican secondary school students from ages 11 to 12 had writing problems. In reality, national assessments have always confirmed this fact. Obviously papers about children’s writing problems have been written by many specialists. But it is interesting to consider this issue in relation to cultural psychology. In addition, this perspective shows the subject in his own singularity in interaction with his social background. It appears that stories, presented as social background’s products, are considered as systems which make sense for students who are in cognitive distress. Skills in writting will thus become for us a kind of mirror to assess the quality of thinking.

http://www.theses.fr/2015AGUY0867/document

Éditeur(s) : HAL CCSD
Résumé : International audience
Half away between edge detection and object recognition this study aim to characterize singularities in order to guide this two phases. The caracterization is obtained with a generalization of the Lipschitz exponents .for complex structures. This new characterization is called " maxima chain " and integrates the notion of value and spatial repartition of the maxima. The maxima chains are obtained with a multiscale decomposition using a Diadic Discrete Wavelet Transform (DDWT). We use the maxima of the gradient image computed with the wavelet details. The local maxima detect the position of irregular structures (edges) in the image (Canny algorithm). Then we characterize each maxima using their evolution across the different scales. A classification is made using the maxima chains. We integrate the classification to eliminate unwanted maxima (from noise or other objects) to drive the search of closed contours. In fact, there is a totally different signature from one maxima to another depending on the parameters of the objects : nature, shape, size, gray scale, texture, ...
RFIA Proceedings
Toulouse, France

hal-00602265
https://hal.archives-ouvertes.fr/hal-00602265