Éditeur(s) : Gauthier-villars
Résumé : Seismic, Seabeam, magnetic and gravimetrie surveys in the southern part of the N-Fiji basin were conducted during the SEAPSO LEG III Cruise. The active spreading axis was recognized between 17°30'S and 21°S. It consists of a continuous N-S Ridge cross-cut by transverse directions oriented N25 and N45. North of 17°30'S, the spreading System is more complex due to the existence of a possible triple junction located around 15° S. The eastern part of the N-Fiji basin, west of Viti Levu is mostly characterized by alternating highs and deeps (<4,000 m). This area must be regarded no more as a spreading center, but as complex boundary suffering transverse tectonics.
La mission SEAPSO III a permis de localiser une zone d'accrétion active, d'orientation méridienne et pratiquement continue entre 17°30'S et 21° S. Des accidents transverses, qui encadrent ou recoupent cette dorsale, s'orientent autour de deux directions principales N25 et N45. Au Nord de 17 30'S le système d'accrétion, beaucoup plus complexe, annonce la triple jonction reconnue aux alentours de 15" S. La partie orientale du bassin Nord-Fidjien (à l'Ouest de l'île de Viti Levu) est caractérisée par l'alternance de zones hautes et de dépressions dont certaines dépassent 4000 m de profondeur. Il s'agit d'une zone complexe de déformations liées à des accidents cisaillants transverses.
Comptes Rendus de l'Academie des Sciences Serie II (1251-8069) (Gauthier-villars), 1986-06 , Vol. 303 , N. 1 , P. 93-98

Droits : Académie des Sciences
http://archimer.ifremer.fr/doc/00184/29492/27835.pdf
http://archimer.ifremer.fr/doc/00184/29492/

Éditeur(s) : ESPE de la Guadeloupe : Ecole Supérieure du Professorat et de l'Education
Extrait de : "Rencontre avec un pédagogue : Philippe Meirieu", le 14 avril 2016. ESPE Guadeloupe
Description : Philippe Meirieu (professeur émérite en sciences de l'éducation, Université Lumière-Lyon 2) présente une réflexion sur les défis de l'éducation, les processus et l'environnement éducatifs. L'idée d'une démocratisation du savoir, de l'accès au savoir est une ambition pour notre jeunesse n'est pas sans se heurter à des difficultés (décrochage, absentéisme, violence). L'éducation au sens fort ne se réduit pas à l'enseignement ; l'éducation : c'est à la fois les parents, la famille, le voisinage, la construction de l'éducation de l'enfant face à des actes de civilités basiques. Trois niveaux d'acteurs sont essentiels (avec leur spécificité) pour construire le développement et l'autonomie de l'enfant: les parents, l'école, l'environnement. Il insiste sur l'importance du rôle de l'environnement avec les médias, les « prothèses technologiques » et leur impact dans la manière de voir le monde. Il s'agit bien de dire le monde, de montrer le monde, d'expliquer le monde, d'entrer en construction constructive avec l'enfant, de l'aider à exprimer progressivement ce qui l'habite. L'éducation passe par le plaisir d'apprendre, le plaisir de comprendre : « je deviens intelligent de mon langage ». Ce processus éducatif passe par un partenariat interactif, qui ne doit pas être une simple addition d'actions, mais il s'agit d'un partenariat pour trouver la clé, d'une invention collective de la recherche du bon levier, du point d'entrée qui va permettre la construction de l'enfant, de trouver le bon équilibre.

Droits : CC-BY-NC-ND - Attribution - Pas d'utilisation commerciale - Pas de modification
Permalien : http://www.manioc.org/fichiers/V16085
V16085

Résumé : Rapport d'activité 1995 du GAP (Laboratoire Génétique, Aquaculture, Pathologie) de La Tremblade.

Droits : 1995 Ifremer
http://archimer.ifremer.fr/doc/00071/18253/15816.pdf
http://archimer.ifremer.fr/doc/00071/18253/

Éditeur(s) : IEEE
Résumé : It is now well understood that data on soil moisture and sea surface salinity (SSS) are required to improve meteorological and climate predictions. These two quantities are not yet available globally or with adequate temporal or spatial sampling. It is recognized that a spaceborne L-band radiometer with a suitable antenna is the most promising way of fulfilling this gap. With these scientific objectives and technical solution at the heart of a proposed mission concept the European Space Agency (ESA) selected the Soil Moisture and Ocean Salinity (SMOS) mission as its second Earth Explorer Opportunity Mission. The development of the SMOS mission was led by ESA in collaboration with the Centre National d'Etudes Spatiales (CNES) in France and the Centro para el Desarrollo Tecnologico Industrial (CDTI) in Spain. SMOS carries a single payload, an L-Band 2-D interferometric radiometer operating in the 1400-1427-MHz protected band [1]. The instrument receives the radiation emitted from Earth's surface, which can then be related to the moisture content in the first few centimeters of soil over land, and to salinity in the surface waters of the oceans. SMOS will achieve an unprecedented maximum spatial resolution of 50 km at L-band over land (43 km on average over the field of view), providing multiangular dual polarized (or fully polarized) brightness temperatures over the globe. SMOS has a revisit time of less than 3 days so as to retrieve soil moisture and ocean salinity data, meeting the mission's science objectives. The caveat in relation to its sampling requirements is that SMOS will have a somewhat reduced sensitivity when compared to conventional radiometers. The SMOS satellite was launched successfully on November 2, 2009.
Proceedings of the IEEE (0018-9219) (IEEE), 2010-05 , Vol. 98 , N. 5 , P. 666-687

Droits : 2010 IEEE – All Rights Reserved
http://archimer.ifremer.fr/doc/00004/11483/8065.pdf
DOI:10.1109/JPROC.2010.2043032
http://archimer.ifremer.fr/doc/00004/11483/

Éditeur(s) : HAL CCSD Publibook
Résumé : L’association ADJC est née en 2014 de la volonté de favoriser les liens entre doctorant.e.s, jeunes chercheur.e.s et les divers membres de la communauté universitaire et scientifique de l’Université des Antilles.Elle se compose de doctorant.e.s, de jeunes chercheur.e.s et ami.e.s de l’association.Ses principaux objectifs :- Fédérer les doctorant.e.s, rompre l’isolement, créer des liens.- Promouvoir les études doctorales dispensées au sein de l’université.- Accompagner les doctorant.e.s dans leur projet de recherche et professionnel- Valoriser leurs travaux scientifiques auprès du plus grand nombre, étudiants, citoyens, décideurs économiques et politiques.
International audience
La deuxième édition de la Journée d'Études Scientifiques (J.E.S) de l'association Ansanm Doctorant.e.s et Jeunes Chercheur.e.s s'est tenue le 21 avril 2016, en prenant pour thématique celle qui porte le nouvel intitulé des Écoles doctorales de l'Université des Antilles : « La recherche scientifique en milieu insulaire tropical ». Les présentations pluridisciplinaires sur lesquelles reviennent ces actes ont dessiné les contours de territoires en mouvement, marqués par la complexité et la richesse de leurs biodiversités, leurs histoires et leurs cultures.
https://hal.archives-ouvertes.fr/hal-01575329

ISBN : 9782753904538
hal-01575329
https://hal.archives-ouvertes.fr/hal-01575329

Éditeur(s) : 3e Rencontres Scientifiques Internationales du contrat de baie de la rade de Brest. Brest 14-16 mars 1995
Résumé : Aquaculture production of scallop has been identified by a series of technical operations during the past ten years programme under a partnership involving the fishermen organizations with regional and national grants. 3 million juveniles have been produced annually, giving a potential recapture by fishing of 100 to 120 tonnes 3 years later. Results in terms of technical and economical approach have pointed out the principal unknown factors responsable for high costs. 7he pilot programme aims to increase the production to reach a level of 5 million juveniles to support the fishery of the rade de Brest and induce new management of the resources. Two priorities were selected, control of the reproduction in the hatchery to obtain reliable larval and postlarval rearing during a larger period of the year, mainly during summer, and improvement of survival rate of the juveniles by minimizing stress when manipulating the animals. But biological and ecological mechanisms are still poorly understoodfor scallop and generally bibvalves and the last two years have shown unchanged results. The technical pathways shows interactions between the different steps of the production of juveniles where different teams operate separately. Management of the livestock has to be developed to increase the survival rate by better breeding but also to reduce the loss by adapted and coordinated practices. Recapture results indicate that fishery strategies depend also on the production of juvenile, and could orientate the management of the hatchery.

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/00044/15494/12860.pdf
http://archimer.ifremer.fr/doc/00044/15494/

Éditeur(s) : HAL CCSD Société Géologique de France
Résumé : International audience
The seaward extension of onshore formations and structures were previously almost unknown in Provence. The interpretation of 2D high-resolution marine seismic profiles together with the integration of sea-bottom rock samples provides new insights into the stratigraphic, structural and paleogeographic framework of pre-Messinian Salinity Crisis (MSC) deposits of the Provence continental shelf. Seven post-Jurassic seismic units have been identified on seismic profiles, mapped throughout the offshore Provence area and correlated with the onshore series. The studied marine surface and sub-surface database provided new insights into the mid and late Cretaceous paleogeography and structural framework as well as into the syn-and post-rift deformation in Provence. Thick (up to 2000 m) Aptian-Albian series whose deposition is controlled by E-W-trending faults are evidenced offshore. The occurrence and location of the Upper Cretaceous South-Provence basin is confirmed by the thick (up to 1500 m) basinal series downlaping the Aptian-Albian unit. This basin was fed in terrigenous sediments by a southern massif (" Massif Méridional ") whose present-day relict is the Paleozoic basement and its sedimentary cover from the Sicié imbricate. In the bay of Marseille, thick syn-rift (Rupelian to Aquitanian) deposition occurred (>1000 m). During the rifting phase, syn-sedimentary deformations consist of dominant N040 to N060 sub-vertical faults with a normal component and N050 drag-synclines and anticlines. The syn-rift and early post-rift units (Rupelian to early Burdigalian) are deformed and form a set of E-W-trending en echelon folds that may result from sinistral strike-slip reactivation of N040 to N060 normal faults during a N-S com-pressive phase of early-to-mid Burdigalian age (18-20 Ma). Finally, minor fault reactivation and local folding affect post-rift deposits within a N160-trending corridor localized south of La Couronne, and could result from a later, post-Burdigalian and pre-Pliocene compressive phase.
Cadre tectonostratigraphique des formations anté-pliocènes du plateau continental de Provence (golfe du Lion oriental, SE France) Mots-clés. – Géologie marine, Tectonostratigraphie, Stratigraphie sismique, Paléogéographie crétacée, Rifting oligo-miocène, Compression post-rift Résumé. – Le prolongement en mer des formations et des structures provençales était jusqu'alors largement inconnu.L'interprétation de profils de sismique-réflexion marine 2D et l'intégration de dragages et carottages du fond-marin ont permis d'apporter des éléments nouveaux concernant le cadre stratigraphique, structural et paléogéographique des dé-pôts anté-Messiniens du plateau continental de Provence. Sept unités sismiques post-jurassiques ont été identifiées sur les profils sismiques, cartographiées à travers le plateau continental et corrélées avec les séries affleurant à terre. Une épaisse unité apto-albienne (jusqu'à 2000 m) dont le dépôt est contrôlé par des failles E-W a été mise en évidence en mer. L'existence d'un bassin subsident au Crétacé supérieur sur le plateau continental de Provence a été confirmée par le développement d'une épaisse série de bassin (jusqu'à 1500 m) reposant en downlap sur l'Apto-Albien. Le socle mé-tamorphique de l'écaille de Sicié et sa couverture sédimentaire peut être considéré comme une relique allochtone du « Massif Méridional » ayant alimenté le Bassin sud-provençal en éléments terrigènes au Crétacé supérieur. Dans la rade de Marseille, une épaisse unité syn-rift (Rupélien à Aquitanien) a été mise en évidence (>1000 m), structurée en une série de synformes en échelon d'axe E-W et affectée par des failles d'orientation dominante N040 à N060. Sur le flanc sud des synformes, la formation de plis d'axe N050 est associée à une déformation syn-sédimentaire. La formation des synformes en échelon d'axe E-W résulterait d'une réactivation en décrochement des failles N040 à N060 pendant une phase de compression N-S dont l'âge est compris entre le Burdigalien inférieur et moyen (18-20 Ma). Enfin, les dépôts post-rift sont affectés par des déformations mineures (réactivation de failles et plis associés), le long d'un couloir d'orientation N160 à l'ouest de la baie de Marseille, attribuables à une phase de compression post-burdigalienne et anté-pliocène.
ISSN: 0037-9409

hal-01463727
https://hal-amu.archives-ouvertes.fr/hal-01463727
https://hal-amu.archives-ouvertes.fr/hal-01463727/document
https://hal-amu.archives-ouvertes.fr/hal-01463727/file/Fournier_et_al_Provence_2016.pdf
DOI : 10.2113/gssgfbull.187.4-5.187

Éditeur(s) : HAL CCSD Météo et Climat
Résumé : International audience
D'initiative française, le projet international HyMeX a pour objectif d'améliorer la compréhension du cycle de l'eau en Méditerranée, de sa variabilité, de l'échelle de l'événement météorologique aux échelles saisonnières et interannuelles, et de ses caractéristiques sur une décennie, dans un contexte de changement global. Le projet est motivé par le rôle déterminant des processus de mésoéchelle, couplés entre l'atmosphère, la mer et la terre, sur la variabilité du système climatique et sur le déclenchement d'événements hydrométéorologiques extrêmes (précipitations et inondations, vents forts et convection océanique, canicules et sécheresses). Le projet vise enfin à évaluer les conséquences de ces événements extrêmes sur la vulnérabilité sociale et économique de cette région et sa capacité d'adaptation.
ISSN: 0026-1181

hal-00828758
https://hal.archives-ouvertes.fr/hal-00828758
https://hal.archives-ouvertes.fr/hal-00828758/document
https://hal.archives-ouvertes.fr/hal-00828758/file/meteo_2013_80_23%20%281%29.pdf
DOI : 10.4267/2042/48792

Éditeur(s) : HAL CCSD Météo et Climat
Résumé : International audience
Les risques hydrométéorologiques sont au coeur du programme de recherche HyMeX sur le cycle de l'eau en Méditerranée. HyMeX a pour ambition d'améliorer leur prévision, de mieux connaître leur variabilité à l'échelle pluriannuelle et de renseigner sur leur évolution, dans le contexte du changement climatique. À cette fin, deux campagnes de mesures dédiées à ces événements extrêmes (SOP1 : pluies intenses et crues rapides ; SOP2 : vents forts et formation d'eaux denses) sont organisées en Méditerranée nord-occidentale, entre septembre 2012 et mars 2013.
ISSN: 0026-1181

hal-00829760
https://hal.archives-ouvertes.fr/hal-00829760
DOI : 10.4267/2042/48793

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
ISSN: 0043-1648

hal-01679411
https://hal.univ-antilles.fr/hal-01679411
DOI : 10.1016/j.wear.2004.11.019

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
11 4 : CEA/HC 12 13 Corresponding author: 14 pierre.legoff@cea.fr -+333 80 23 40 00 -+333 80 23 52 09 15 16 Abstract 17 As one of the three natural isotopes of hydrogen, tritium is ubiquitous and might potentially 18 be present in any water or organic molecule that constitutes a biological matrix. Milk is one of 19 the most frequently monitored foodstuffs in the vicinity of chronic release of radionuclides, as 20 it is a very common product and also because it integrates deposition on large areas of grass at 21 a local scale. Different parameters have been studied to assess their impact on the reliability 22 of tritium measurements. The volume of the sample, the technique used to extract the water 23 and the level of dehydration modulate the results but in different ways: dispersion of results, 24 under-or overestimation of the tritium activity. The influence of sample storage and 25 preparation has also been investigated. Methodological improvements of tritium 26 measurements in the free water of milk are proposed. 27 28
ISSN: 0265-931X

hal-01117741
https://hal.archives-ouvertes.fr/hal-01117741
https://hal.archives-ouvertes.fr/hal-01117741/document
https://hal.archives-ouvertes.fr/hal-01117741/file/Tritium%20in%20the%20free%20water%20of%20milk-FINAL.pdf
DOI : 10.1016/j.jenvrad.2013.09.006

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
During the early years of the Iceland Deep Drilling Project (IDDP), development of three distinctive technological and scientific approaches were formalised and then carried out until 2010 within a European funded project called HiTI (high temperature instruments for supercritical geothermal reservoir characterisation and exploitation). These approaches were: (1) development of several downhole instruments allowing them to function up to 300 ◦C and 400 ◦C, (2) identification of two new Na/Li cation ratio geothermometric relationships valid at very high temperature, (3) tracer testing with high temperature tolerant organic isomers and finally and (4) basalt rock deformation and petrophysical properties laboratory investigations at high temperature and pressure conditions.
ISSN: 0375-6505

hal-00921127
https://hal-brgm.archives-ouvertes.fr/hal-00921127
DOI : 10.1016/j.geothermics.2013.07.008

Éditeur(s) : HAL CCSD Blackwell Publishing
Résumé : International audience
Pliocene and Pleistocene deposits from Grande-Terre (Guadeloupe archipelago, French Lesser Antilles) provide a remarkable example of an isolated carbonate system built in an active margin setting, with sedimentation both controlled by rapid sea-level changes and tectonic movements. Based on new field, sedimentological and palaeontological analyses, these deposits have been organized into four sedimentary sequences (S1 to S4) separated by three subaerial erosion surfaces (SB0, SB1 and SB2). Sequences S1 and S2 ('Calcaires inférieurs à rhodolithes') deposited during the late Zanclean to early Gelasian (planktonic foraminiferal Zones PL2 to PL5) in low subsidence conditions, on a distally steepened ramp dipping eastward. Red algal-rich deposits, which dominate the western part of Grande-Terre, change to planktonic foraminifer-rich deposits eastward. Vertical movements of tens of metres were responsible for the formation of SB0 and SB1. Sequence S3 ('Formation volcano-sédimentaire', 'Calcaires supérieurs à rhodolithes' and 'Calcaires à Agaricia') was deposited during the late Piacenzian to early Calabrian (Zones PL5 to PT1a) on a distally steepened, red algal-dominated ramp that changes upward into a homoclinal, coral-dominated ramp. Deposition of Sequence S3 occurred during a eustatic cycle in quiet tectonic conditions. Its uppermost boundary, the major erosion surface SB2, is related to the Cala1 eustatic sea-level fall. Finally, Sequence S4 ('Calcaires à Acropora') probably formed during the Calabrian, developing as a coral-dominated platform during a eustatic cycle in quiet tectonic conditions. The final emergence of the island could then have occurred in late Calabrian times.
ISSN: 1469-3496

hal-00760906
https://hal.archives-ouvertes.fr/hal-00760906
DOI : 10.1111/j.1365-3091.2011.01311.x

Éditeur(s) : Elsevier Science Bv
Résumé : During the Echolag cruise (13 February-8 March 2007), the effect of 16-30 knot trade winds on abundance, community structure and dynamics of phytoplankton was investigated in the southern part of the New Caledonian coral reefs and surrounding oceanic waters. In this area, the coral reefs form two horn-like structures (hereinafter referred to as 'horn reefs'), oriented south-east, and separated by a relatively deep valley. Three repeated samplings at one week intervals of a 32 station array showed that trade winds induce surface water cooling and significant enrichment of mid- and bottom waters above the reef shelf. This enrichment appeared as the result of a general rise of the oceanic thermocline and nitracline due to the combination of trade winds and tidally-generated internal waves between the horn reefs. It was accompanied by a factor of 1.5 and 2.3 mean increase for the chlorophyll concentration and picoplankton-nanoplankton cell number, respectively. From diel variations of in vivo chlorophyll a fluorescence and hourly sampling, phytoplankton gross growth rate was estimated to be 1-1.35 divisions per day and was quasi balanced with phytoplankton mortality for a 24 h period.
Journal Of Marine Systems (0924-7963) (Elsevier Science Bv), 2010-09 , Vol. 82 , N. 4 , P. 230-244

Droits : 2010 Elsevier B.V. All rights reserved.
http://archimer.ifremer.fr/doc/00013/12437/9258.pdf
DOI:10.1016/j.jmarsys.2010.05.010
http://archimer.ifremer.fr/doc/00013/12437/

Éditeur(s) : HAL CCSD Landes Bioscience
Résumé : International audience
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
Autophagy

hal-00735751
https://hal.archives-ouvertes.fr/hal-00735751
PUBMED : 22966490

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Chlordecone is a persistent organochlorine pesticide that was used in the French West Indies until the early 1990s for banana weevil borer control. Human exposure to this chemical in this area still occurs nowadays due to consumption of contaminated food. Although adverse effects on neurodevelopment, including tremors and memory deficits, have been documented in experimental studies conducted with rodents exposed during the gestational and neonatal periods, no study has been conducted yet to determine if chlordecone alters child development. This study examines the relation of gestational and postnatal exposure to chlordecone to infant development at 18 months of age in a birth-cohort of Guadeloupean children. In a prospective longitudinal study conducted in Guadeloupe (Timoun mother-child cohort study), exposure to chlordecone was measured at birth from an umbilical cord blood sample (n=141) and from a breast milk sample collected at 3 months postpartum (n=75). Toddlers were assessed using an adapted version of the Ages and Stages Questionnaire. Higher chlordecone concentrations in cord blood were associated with poorer fine motor scores. When analyses were conducted separately for boys and girls, this effect was only observed among boys. These results suggest that prenatal exposure to chlordecone is associated with specific impairments in fine motor function in boys, and add to the growing evidence that exposure to organochlorine pesticides early in life impairs child development.
ISSN: 0161-813X

hal-00875907
https://hal.archives-ouvertes.fr/hal-00875907
PUBMED : 23376090
DOI : 10.1016/j.neuro.2013.01.007

Éditeur(s) : HAL CCSD CNRS éditions
Résumé : International audience
Die antike Siedlung von Mandeure und Mathay (Epomanduodurum), welche durch ihre Größe und ihre monumentale Ausstattung als die zweitwichtigste Stadt der Sequaner hinter der Civitashauptstadt Besançon betrachtet wird, ist Gegenstand eines interdisziplinarischen Forschungsprogramms. Dieser Artikel stellt eine Bilanz der Ergebnisse der zwischen 2001 und 2004 durchgeführten Forschungen dar. Im Mittelpunkt der Forschungen der ersten Phase stand der zentralen Teil der Siedlung mit dem Bereich Heiligtum-Theater-spätrömische Befestigung, der für die Problematik der Entstehung, der Entwicklung und dem Ende der römischen Besiedlung besonders interessant ist. Verschiedene, sich ergänzende Projekte wurden eingeleitet: Erforschung des alten Dokumentarbestandes, geophysikalische Prospektionen, geoarchäologische Sondierungen, Plangrabungen, architektonische Untersuchunge. Durch diese Projekte war es möglich, die Kenntnisse über die drei wichtigen Großbauten (Heiligtum-Theater-spätrömische Befestigung) grundsätzlich zu vertiefen und insbesondere die geophysikalischen Prospektionsergebnisse lassen in bemerkenswerter Weise einen dichten Baubestand dieses Stadtteils erkennen. Schließlich konnte die Funktion und die Entwicklung der Flußebene des Doubs in diesem Bereich besser verstanden werden als auch die Art und Weise in welcher die antike Monumentalanlage in diesen einzigartigen natürlichen Rahmen einbezogen wurde.
Since 2001, a collective pluridisciplinary research programme is being undertaken on the antique town of Epomanduodurum in the communes of Mandeure and Mathay. This site is considered like the second one of the Sequani, for its dimensions and the monuments, after the civitas capital, Besançon. This article is an assessment of the investigations conducted between 2001 and 2004. During this period, the central part of the site was studied (sanctuary, theatre, Late fortification area), considered as the most significant for the question of the birth, development and decline of the town. Various complementary approaches have been carried out: study of archives, geophysical and geoarchaeological survey, extent excavations, architectural analyses. They lead to a better understanding of the three main buildings (the Celtic and Gallo-Roman sanctuary, the theatre of the Principate, the Late Antique fortification) and they add considerable informations about the pattern of settlement of this area; so it is possible to detect more precisely the spatial organization and finally to understand how the alluvial plain of the Doubs river was functioning and how the monumental complex has been integrated in such a peculiar landscape.
L'agglomération antique d'Epomanduodurum, située sur les communes de Mandeure et Mathay, et considérée comme la seconde du pays séquane par la taille et la parure monumentale, derrière la capitale de cité, Besançon, fait l'objet d'un programme collectif de recherche, pluridisciplinaire, depuis 2001. Cet article dresse un bilan des résultats des fouilles réalisées entre 2001 et 2004. Dans cette première phase, les investigations ont porté principalement sur la partie centrale du site (secteur sanctuaire-théâtrefortification tardive), perçue comme particulièrement intéressante pour la problématique de la naissance, du développement et du déclin de l'agglomération. Différentes approches complémentaires ont été lancées : étude du fond documentaire ancien, prospections géophysiques, sondages géoarchéologiques, fouilles extensives, études architecturales. Elles ont permis d'approfondir la connaissance des trois principaux édifices (sanctuaire laténien et gallo-romain, théâtre du Haut-Empire, fortification du Bas-Empire), de compléter de façon très notable la trame de l'occupation de ce secteur, et donc d'en mieux percevoir l'organisation spatiale, enfin de mieux comprendre le fonctionnement de la plaine alluviale du Doubs et l'insertion dans ce contexte naturel particulier d'un complexe monumental antique.
ISSN: 0016-4119

halshs-00718356
https://halshs.archives-ouvertes.fr/halshs-00718356

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
CONTEXT: Chlordecone, an environmentally persistent organochlorine insecticide used intensively in banana culture in the French West Indies until 1993, has permanently polluted soils and contaminated foodstuffs. Consumption of contaminated food is the main source of exposure nowadays. We sought to identify main contributors to blood chlordecone concentration (BCC) and to validate an exposure indicator based on food intakes. MATERIAL AND METHODS: We used a food frequency questionnaire (FFQ) completed by a sample of 194 pregnant women to estimate their dietary exposure to chlordecone and compared it to blood levels. In a first approach, chlordecone daily intake was estimated as the product of daily eaten quantity of 214 foodstuffs, multiplied by their chlordecone content, and summed over all items. We then predicted individual blood chlordecone concentration with empirical weight regression models based on frequency of food consumption, and without contamination data. RESULTS: Among the 191 subjects who had BCC determination, 146 (76%) had detectable values and mean BCC was 0.86 ng/mL (range < LOD-13.2). Mean per capita dietary intake of chlordecone was estimated at 3.3 microg/day (range: 0.1-22.2). Blood chlordecone levels were significantly correlated with food exposure predicted from the empirical weight models (r=0.47, p<0.0001) and, to a lesser extent, with chlordecone intake estimated from food consumption and food contamination data (r=0.20, p=0.007). Main contributors to chlordecone exposure included seafood, root vegetables, and Cucurbitaceous. CONCLUSION: These results show that the Timoun FFQ provides valid estimates of chlordecone exposure. Estimates from empirical weight models correlated better with blood levels of chlordecone than did estimates from the dietary intake assessment.
ISSN: 0013-9351

inserm-00517109
http://www.hal.inserm.fr/inserm-00517109
http://www.hal.inserm.fr/inserm-00517109/document
http://www.hal.inserm.fr/inserm-00517109/file/Pesticide_exposureofpregnantwomeninGuadeloupe.pdf
DOI : 10.1016/j.envres.2009.10.015

Éditeur(s) : HAL CCSD American Geophysical Union (AGU)
Résumé : International audience
[1] Zircons and monazites from 6 samples of the North Ayilari dextral shear zone (NAsz), part of the Karakorum fault zone (KFZ), have been dated with the U-Th-Pb method, using both ID-TIMS and SIMS techniques. The ages reveal (1) inheritance from several events spanning a long period between the late Archean and the Jurassic; (2) an Eocene-Oligocene magmatic event (similar to 35-32 Ma); (3) an Oligo-Miocene magmatic event (similar to 25-22 Ma), at least partly synkinematic to the right-lateral deformation; and (4) a period of metamorphism metasomatism (similar to 22-14 Ma) interpreted as thermal and fluid advection in the shear zone. The Labhar Kangri granite located similar to 375 km farther Southeast along the KFZ is dated at 21.1 +/- 0.3 Ma. Such occurrence of several Oligo-Miocene granites along the KFZ, some of which show evidence for synkinematic emplacement, suggests that the fault zone played an important role in the genesis and /or collection of crustal melts. We discuss several scenarios for the onset and propagation of the KFZ, and offset estimates based on the main sutures zones. Our preferred scenario is an Oligo-Miocene initiation of the fault close to the NA range, and propagation along most of its length prior to similar to 19 Ma. In its southern half, the averaged long-term fault-rate of the KFZ is greater than 8 to 10 mm/a, in good agreement with some shorter-term estimates based on the Indus river course, or Quaternary moraines and geodesy. Our results show the KFZ cannot be considered as a small transient fault but played a major role in the collision history.
ISSN: 0278-7407

hal-00412570
https://hal.archives-ouvertes.fr/hal-00412570
DOI : 10.1029/2007TC002184

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
Retreatment with pegylated interferon (peg-IFN) and ribavirin (RBV) results in poor sustained virological response (SVR) rates in human immunodeficiency virus (HIV)/hepatitis C virus (HCV)-coinfected patients. There are limited data regarding the use of telaprevir plus peg-IFN/RBV in this population. HIV type 1-infected patients who previously failed ≥12 weeks of peg-IFN/RBV for HCV genotype 1 coinfection were enrolled in a single-arm, phase 2 trial. Patients with cirrhosis and previous null response were excluded. Authorized antiretrovirals were tenofovir, emtricitabine, efavirenz, atazanavir, and raltegravir. All patients received peg-IFN alfa-2a (180 µg/week) plus RBV (1000-1200 mg/day) for 4 weeks, followed by telaprevir (750 mg or 1125 mg every 8 hours with efavirenz) plus peg-IFN/RBV for 12 weeks and peg-IFN/RBV for 32-56 weeks according to virological response at week 8. The primary endpoint was the SVR rate at 24 weeks after the end of treatment (SVR24). Sixty-nine patients started treatment; SVR24 was achieved in 55 (80% [95% confidence interval, 68%-88%). SVR24 was not influenced by baseline fibrosis stage, IL28B genotype, antiretroviral regimen, HCV subtype, CD4 cell count, previous response to HCV treatment, HCV RNA level, or HCV RNA decline at week 4. HCV treatment was discontinued for adverse events (AEs) in 20% of patients, including cutaneous (4%), psychiatric (4%), hematological (6%), and other AEs (6%). Peg-IFN or RBV dose reduction was required in 23% and 43% of patients, respectively. Seventy percent of patients required erythropoietin, blood transfusions, or RBV dose reduction for anemia. Two patients died during the study. No HIV breakthrough was observed. Despite a high discontinuation rate related to toxicity, a substantial proportion of treatment-experienced HIV-coinfected patients achieved SVR24 with a telaprevir-based regimen. Clinical Trials Registration. NCT01332955.
ISSN: 1058-4838

hal-01118447
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118447
PUBMED : 25139963
DOI : 10.1093/cid/ciu659