Éditeur(s) : Grangé Grangé ( Paris )
Résumé : (Statement of Responsibility) par Mr. H. Dl.
Title vignette; head- and tailpieces.
Haiti
France
Haiti
Haiti

02707879
02000100
ocm02707879

Éditeur(s) : Bibliothèque Nationale d'Haïti Bibliothèque Nationale d'Haïti ( Port-au-Prince, Haiti )

Éditeur(s) : Grangé Grangé ( Paris )
Résumé : (Statement of Responsibility) par Mr. H. Dl.
Title vignette; head- and tailpieces.
Haiti
France
Haiti
Haiti

02707879
02000100
ocm02707879

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
ISSN: 0003-4975

hal-01563338
http://hal.univ-brest.fr/hal-01563338
DOI : 10.1016/j.athoracsur.2016.03.093
PUBMED : 27262916

Éditeur(s) : Gauthier-villars
Résumé : The aim of the joint French-British CYAPORC submersible cruise was the exploration and sampling of the Porcupine and Goban Escarpments. A paleozoic mesozoic sedimentary cover has been evidenced abov ea caledonian or older cristalline basement on the Porcupine scarp. On the Goban scarp, the observed outcrops are mainly lower Cretaceous carbonates overlying paleozoic sandstones
La campagne de plongée franco-britannique CYAPORC avait pour objet l'exploration et l'échantillonnage des escarpements de Porcupine et de Goban. Sur l'escarpement de Porcupine au Nord, on a mis en évidence, au-dessus d'un socle cristallin calédonien ou plus ancien, une couverture sédimentaire paléozoïque puis mésozoïque. Sur l'escarpement de Goban, les affleurements observés sont des séries du Crétacé inférieur reposantsur des niveaux de grès paléozoïques.
Comptes Rendus de l'Academie des Sciences Serie II (1251-8069) (Gauthier-villars), 1987-04 , Vol. 304 , N. 16 , P. 1003-1008

Droits : Académie des Sciences
http://archimer.ifremer.fr/doc/00184/29489/27853.pdf
http://archimer.ifremer.fr/doc/00184/29489/

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
The IL-33/ST2 axis is known to be involved in liver pathologies. Although, the IL-33 levels increased in sera of viral hepatitis patients in human, the cellular sources of IL-33 in viral hepatitis remained obscure. Therefore, we aimed to investigate the expression of IL-33 in murine fulminant hepatitis induced by a Toll like receptor (TLR3) viral mimetic, poly(I:C) or by pathogenic mouse hepatitis virus (L2-MHV3). The administration of poly(I:C) plus D-galactosamine (D-GalN) in mice led to acute liver injury associated with the induction of IL-33 expression in liver sinusoidal endothelial cells (LSEC) and vascular endothelial cells (VEC), while the administration of poly(I:C) alone led to hepatocyte specific IL-33 expression in addition to vascular IL-33 expression. The hepatocyte-specific IL-33 expression was down-regulated in NK-depleted poly(I:C) treated mice suggesting a partial regulation of IL-33 by NK cells. The CD1d KO (NKT deficient) mice showed hepatoprotection against poly(I:C)-induced hepatitis in association with increased number of IL-33 expressing hepatocytes in CD1d KO mice than WT controls. These results suggest that hepatocyte-specific IL-33 expression in poly(I:C) induced liver injury was partially dependent of NK cells and with limited role of NKT cells. In parallel, the L2-MHV3 infection in mice induced fulminant hepatitis associated with up-regulated IL-33 expression as well as pro-inflammatory cytokine microenvironment in liver. The LSEC and VEC expressed inducible expression of IL-33 following L2-MHV3 infection but the hepatocyte-specific IL-33 expression was only evident between 24 to 32h of post infection. In conclusion, the alarmin cytokine IL-33 was over-expressed during fulminant hepatitis in mice with LSEC, VEC and hepatocytes as potential sources of IL-33.
ISSN: 1932-6203

hal-00874120
https://hal.archives-ouvertes.fr/hal-00874120
https://hal.archives-ouvertes.fr/hal-00874120/document
https://hal.archives-ouvertes.fr/hal-00874120/file/Pathogenic_Mouse_Hepatitis-accepted.pdf
DOI : 10.1371/journal.pone.0074278

Éditeur(s) : HAL CCSD
Résumé : International audience
Conférence MISTRALS PAELOMEX
Montpellier, France

hal-01683548
https://hal-univ-tlse2.archives-ouvertes.fr/hal-01683548

Éditeur(s) : Natl Acad Sciences
Résumé : Most marine organisms disperse via ocean currents as larvae, so it is often assumed that larval-stage duration is the primary determinant of geographic range size. However, empirical tests of this relationship have yielded mixed results, and alternative hypotheses have rarely been considered. Here we assess the relative influence of adult and larval-traits on geographic range size using a global dataset encompassing 590 species of tropical reef fishes in 47 families, the largest compilation of such data to date for any marine group. We analyze this database using linear mixed-effect models to control for phylogeny and geographical limits on range size. Our analysis indicates that three adult traits likely to affect the capacity of new colonizers to survive and establish reproductive populations (body size, schooling behavior, and nocturnal activity) are equal or better predictors of geographic range size than pelagic larval duration. We conclude that adult life-history traits that affect the postdispersal persistence of new populations are primary determinants of successful range extension and, consequently, of geographic range size among tropical reef fishes.
Proceedings Of The National Academy Of Sciences Of The United States Of America (0027-8424) (Natl Acad Sciences), 2013-10 , Vol. 110 , N. 41 , P. 16498-16502

Droits : Freely available online through the PNAS open access option.
http://archimer.ifremer.fr/doc/00161/27240/25457.pdf
DOI:10.1073/pnas.1304074110
http://archimer.ifremer.fr/doc/00161/27240/

Éditeur(s) : HAL CCSD American Physiological Society
Résumé : International audience
The IL-33/ST2 axis plays a protective role in T-cell-mediated hepatitis, but little is known about the functional impact of endogenous IL-33 on liver immunopathology. We used IL-33-deficient mice to investigate the functional effect of endogenous IL-33 in concanavalin A (Con A)-hepatitis. IL-33(-/-) mice displayed more severe Con A liver injury than wild-type (WT) mice, consistent with a hepatoprotective effect of IL-33. The more severe hepatic injury in IL-33(-/-) mice was associated with significantly higher levels of TNF-alpha and IL-1 beta and a larger number of NK cells infiltrating the liver. The expression of Th2 cytokines (IL-4, IL-10) and IL-17 was not significantly varied between WT and IL-33(-/-) mice following Con A-hepatitis. The percentage of CD25(+) NK cells was significantly higher in the livers of IL-33(-/-) mice than in WT mice in association with upregulated expression of CXCR3 in the liver. Regulatory T cells (Treg cells) strongly infiltrated the liver in both WT and IL-33(-/-) mice, but Con A treatment increased their membrane expression of ST2 and CD25 only in WT mice. In vitro, IL-33 had a significant survival effect, increasing the total number of splenocytes, including B cells, CD4(+) and CD8(+) T cells, and the frequency of ST2(+) Treg cells. In conclusion, IL-33 acts as a potent immune modulator protecting the liver through activation of ST2(+) Treg cells and control of NK cells.
ISSN: 0193-1857

hal-01366372
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01366372
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01366372/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01366372/file/Ablation%20of%20interaction%20between%20IL-33%20and%201%20ST2.pdf
DOI : 10.1152/ajpgi.00097.2016

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The non-classical human leukocyte antigen-G, HLA-G, plays an important role in inducing tolerance, through its immunosuppressive effects on all types of immune cells. Immune tolerance is a key issue in the liver, both in liver homeostasis and in the response to liver injury or cancer. It would therefore appear likely that HLA-G plays an important role in liver diseases. Indeed, this molecule was recently shown to be produced by mast cells in the livers of patients infected with hepatitis C virus (HCV). Furthermore, the number of HLA-G-positive mast cells was significantly associated with fibrosis progression. The generation of immune tolerance is a role common to both HLA-G, as a molecule, and the liver, as an organ. This review provides a summary of the evidence implicating HLA-G in liver diseases. In the normal liver, HLA-G transcripts can be detected, but there is no HLA-G protein. However, HLA-G protein is detectable in the liver tissues and/or plasma of patients suffering from hepatocellular carcinoma, hepatitis B or C, or visceral leishmaniasis and in liver transplant recipients. The cells responsible for producing HLA-G differ between diseases. HLA-G expression is probably induced by microenvironmental factors, such as cytokines. The expression of HLA-G receptors, such as ILT2, ILT4, and KIRD2L4, on liver cells has yet to be investigated, but these receptors have been detected on all types of immune cells, and such cells are present in liver. The tolerogenic properties of HLA-G explain its deleterious effects in cancers and its beneficial effects in transplantation. Given the key role of HLA-G in immune tolerance, new therapeutic agents targeting HLA-G could be tested for the treatment of these diseases in the future.
ISSN: 0168-8278

hal-01134468
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01134468
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01134468/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01134468/file/Biology%20of%20the%20immunomodulatory%20molecule%20HLA-G.pdf
DOI : 10.1016/j.jhep.2015.03.007

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Aims: The aims of this study were to compare short-and long-term outcomes for clinical T2N0 oesophageal cancer with analysis of (i) primary surgery (S) versus neoadjuvant therapy plus surgery (NS), (ii) squamous cell carcinoma and adenocarcinoma subsets; and (iii) neoadjuvant chemoradiotherapy versus neoadjuvant chemotherapy.Methods: Data were collected from 30 European centres from 2000 to 2010. Among 2944 included patients, 355 patients (12.1%) had cT2N0 disease; 285 (S) and 70 (NS), were compared in terms of short-and long-term outcomes. Propensity score matching analyses were used to compensate for differences in baseline characteristics.Results: No significant differences between the groups were shown in terms of in hospital morbidity and mortality. Nodal disease was observed in 50% of S-group at the time of surgery, with 20% pN2/N3. Utilisation of neoadjuvant therapy was associated with significant tumour downstaging as reflected by increases in pT0, pN0 and pTNM stage 0 disease, this effect was further enhanced with neoadjuvant chemoradiotherapy. After adjustment on propensity score and confounding factors, for all patients and subset analysis of squamous cell and adenocarcinoma, neoadjuvant therapy had no significant effect upon survival or recurrence (overall, loco-regional, distant or mixed) compared to surgery alone. There were no significant differences between neoadjuvant chemotherapy and chemoradiotherapy in short-or long-term outcomes.Conclusion: The results of this study suggest that a surgery alone treatment approach should be recommended as the primary treatment approach for cT2N0 oesophageal cancer despite 50% of patients having nodal disease at the time of surgery.
ISSN: 0959-8049

hal-01666517
https://hal.univ-lorraine.fr/hal-01666517
DOI : 10.1016/j.ejca.2015.11.024

Éditeur(s) : HAL CCSD
Résumé : International audience
The paper deals with iterative schemes for finding a zero of a maximal monotone operator. A combination of the auxiliary principle with the Tikhonov method is considered. Under some assumptions the sequence generated by such an iterative scheme is shown to converge to a solution of the problem that is required to satisfy an associated variational inequality
Lecture notes in economics and mathematical systems

hal-00773198
https://hal.univ-antilles.fr/hal-00773198

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Structural analysis along with 40Ar–39Ar and U–Pb datings in the Fuping massif provide new insight into the evolution of the eastern part of the Trans-North China Belt (North China Craton), from 2.7 Ga to 1.8 Ga. D1 is responsible for the development of a dome-and-basin structure coeval with crustal melting giving rise to migmatite and Nanying gneissic granites at 2.1 Ga. This dome-and-basin architecture resulted from the interference between a N–S compression of a weak ductile crust and gravity-driven vertical flow, in a high thermal regime. The next events involved flat lying ductile thrusting (D2) and normal faulting (D3) dated at around 1880 Ma and 1830 Ma, respectively. The D2 and D3 events belong to the Trans-North China Orogeny that results in the final amalgamation of the North China Craton. The D1 deformation is considered as evidence for an earlier orogen developed around 2.1 Ga prior to the Trans-North China Orogeny. The change in the deformation style between the 2.1 Ga and 1.8 Ga could be viewed as a consequence of the cooling of the continental crust in the North China Craton.
ISSN: 0191-8141

insu-00309553
https://hal-insu.archives-ouvertes.fr/insu-00309553
https://hal-insu.archives-ouvertes.fr/insu-00309553/document
https://hal-insu.archives-ouvertes.fr/insu-00309553/file/Trap-JStructuralGeology-2008.pdf
DOI : 10.1016/j.jsg.2008.05.001

Éditeur(s) : HAL CCSD
Résumé : International audience
The k-nearest neighbors (k-NN) classification rule is still an essential tool for computer vision applications, such as scene recognition. However, k-NN still features some major drawbacks, which mainly reside in the uniform voting among the nearest prototypes in the feature space. In this paper, we propose a new method that is able to learn the "relevance" of prototypes, thus classifying test data using a weighted k-NN rule. In particular, our algorithm, called Multi-class Leveraged k-nearest neighbor (MLNN), learns the prototype weights in a boosting framework, by minimizing a surrogate exponential risk over training data. We propose two main contributions for improving computational speed and accuracy. On the one hand, we implement learning in an inherently multiclass way, thus providing significant computation time reduction over one-versus-all approaches. Furthermore, the leveraging weights enable effective data selection, thus reducing the cost of k-NN search at classification time. On the other hand, we propose a kernel generalization of our approach to take into account real-valued similarities between data in the feature space, thus enabling more accurate estimation of the local class density. We tested MLNN on three datasets of natural images. Results show that MLNN significantly outperforms classic k-NN and weighted k-NN voting. Furthermore, using an adaptive Gaussian kernel provides significant performance improvement. Finally, the best results are obtained when using MLNN with an appropriate learned metric distance.
Proceedings of the 10th Asian Conference on Computer Vision, ACCV 2010, November 8-12, 2010, Queenstown, New Zealand
Queenstown, New Zealand

hal-00664606
https://hal.inria.fr/hal-00664606
https://hal.inria.fr/hal-00664606/document
https://hal.inria.fr/hal-00664606/file/mlnn_accvfinal.pdf

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Diagnosis of toxoplasmic encephalitis (TE) in patients with AIDS is not straightforward because clinicians rely initially on an empiric diagnosis based on clinical and radiographic improvement to specific anti-Toxoplasma gondii therapy. There is therefore a need for biological tools to improve the diagnosis of TE, especially in tropical areas where this diagnosis is likely to be underestimated. The use of PCR testing in blood samples for the diagnosis of TE has been limited by its poor sensitivity in the studies conducted in Europe. In tropical South America, the results of PCR sensitivity in blood samples were controversial. Considering that T. gondii strains from tropical South America have substantial genetic and pathogenic differences with those from USA and Europe, it is therefore important to re-evaluate the performance of the PCR assay in blood samples for the diagnosis of TE in AIDS patients from this region. Our results showed that the only interest of PCR would be in the most severe forms of TE with altered consciousness because PCR is more likely to be positive. We also provided important genotyping data on T. gondii strains isolated in human cases of toxoplasmosis in the Caribbean and in South America.
ISSN: 1935-2727

hal-01503761
https://hal-unilim.archives-ouvertes.fr/hal-01503761
https://hal-unilim.archives-ouvertes.fr/hal-01503761/document
https://hal-unilim.archives-ouvertes.fr/hal-01503761/file/journal.pntd.0004790.pdf
DOI : 10.1371/journal.pntd.0004790

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Voting rules relying on k-nearest neighbors (k-NN) are an effective tool in countless many machine learning techniques. Thanks to its simplicity, k-NN classification is very attractive to practitioners, as it enables very good performances in several practical applications. However, it suffers from various drawbacks, like sensitivity to "noisy" instances and poor generalization properties when dealing with sparse high-dimensional data. In this paper, we tackle the k-NN classification problem at its core by providing a novel k-NN boosting approach. Namely, we propose a supervised learning algorithm, called Universal Nearest Neighbors (UNN), that induces a leveraged k-NN rule by globally minimizing a surrogate risk upper bounding the empirical misclassification rate over training data. Interestingly, this surrogate risk can be arbitrary chosen from a class of Bregman loss functions, including the familiar exponential, logistic and squared losses. Furthermore, we show that UNN allows to efficiently filter a dataset of instances by keeping only a small fraction of data. Experimental results on the synthetic Ripley's dataset show that such a filtering strategy is able to reject "noisy" examples, and yields a classification error close to the optimal Bayes error. Experiments on standard UCI datasets show significant improvements over the current state of the art.
ISSN: 0925-2312

hal-00664462
https://hal.inria.fr/hal-00664462

Éditeur(s) : HAL CCSD Inter-Research
Résumé : International audience
The effects of global change are particularly serious in areas where range shiftsof species are physically constrained such as the Ligurian Sea, which is one ofthe coldest sectors of the Mediterranean. In this basin, historical informationon water temperature (from the sea surface down to 75 m depth) dates backto the 1950s. Early studies also recorded warm-water species occurrence.Thanks to these data we provide the first detailed characterization of watertemperature variation from 1958 up to 2010 in the layer 0–75 m depth. Wecoupled this analysis with the available information on rocky reef epibenthiccommunities (literature review from 1955 to 1964 and field data from 1980 to2010). The analysis of water temperature revealed several patterns of variation:a cooling phase from 1958 to 1980, a phase of rapid warming from 1980 to1990 and a phase of slower warming from 1990 to 2010. Inter-annual variationin temperature increased over the entire period for the water layer down to20 m. Warm-water native and alien species richness increased during thewarming phases. Literature estimates suggest a decrease in warm-water nativespecies richness during the cooling phase. The analysis of quantitative data collectedin the early 1990s and late 2000s indicated a decrease in the cover ofwarm-water native species on shallow rocky reefs and an increase in deeperwaters. We argue that increased inter-annual variation in water temperaturemay disadvantage native warm-water species in shallow waters. Our resultsindicate that the effect of temperature rises in cold, constrained basins may bemore complex than the simple prediction of species changing their geographicalrange according to their thermal limits.
Marine Ecology Progress Series

hal-01239259
https://hal-univ-perp.archives-ouvertes.fr/hal-01239259
DOI : 10.1111/maec.12277

Droits : 2010 Ifremer/Observatoire du Patrimoine Naturel de Bretagne
http://archimer.ifremer.fr/doc/00026/13737/10865.pdf
http://archimer.ifremer.fr/doc/00026/13737/

Éditeur(s) : HAL CCSD IEEE
Résumé : International audience
Recent works display that large scale image classification problems rule out computationally demanding methods. On such problems, simple approaches like k-NN are affordable contenders, with still room space for statistical improvements under the algorithmic constraints. A recent work showed how to leverage k-NN to yield a formal boosting algorithm. This method, however, has numerical issues that make it not suited for large scale problems. We propose here an Adaptive Newton-Raphson scheme to leverage k-NN, N³, which does not suffer these issues. We show that it is a boosting algorithm, with several key algorithmic and statistical properties. In particular, it may be sufficient to boost a subsample to reach desired bounds for the loss at hand in the boosting framework. Experiments are provided on the SUN, and Caltech databases. They confirm that boosting a subsample -- sometimes containing few examples only -- is sufficient to reach the convergence regime of N³. Under such conditions, N³ challenges the accuracy of contenders with lower computational cost and lower memory requirement.
IEEE International Workshop on Machine Learning for Signal Processing
Southampton, United Kingdom

hal-00959125
https://hal.archives-ouvertes.fr/hal-00959125
https://hal.archives-ouvertes.fr/hal-00959125/document
https://hal.archives-ouvertes.fr/hal-00959125/file/BNNB_mlsp2013.pdf

Éditeur(s) : HAL CCSD Impact journals
Résumé : International audience
Interleukin (IL)-33 has been recently reported to be strongly pro-fibrogenic in various models of liver disease. Our aim was to study the role of endogenous IL-33 in a diet-induced model of steatohepatitis. IL-33 deficient mice and wild type (WT) littermates received a high-fat diet (HFD), or a standard diet for 12 weeks. The HFD-induced steatohepatitis was associated with an upregulation of IL-33 transcripts and protein. An insulin tolerance test revealed lower systemic insulin sensitivity in IL33-/-HFD mice than in WT-HFD mice. Nevertheless, IL-33 deficiency did not affect the severity of liver inflammation by histological and transcriptomic analyses, nor the quantity of liver fibrosis. Livers from HFD mice had more myeloid populations, markedly fewer NKT cells and higher proportion of ST2+ Treg cells and ST2+ type 2 innate lymphoid cells (ILC2), all unaffected by IL-33 deficiency. In conclusion, deficiency of endogenous IL-33 does not affect the evolution of experimental diet-induced steatohepatitis towards liver fibrosis.
ISSN: 1949-2553

hal-01578584
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01578584
DOI : 10.18632/oncotarget.18335
PUBMED : 28611297