Éditeur(s) : Agence des 50 pas géométriques
Extrait de : 3e forum Bodlanmè. "Une zone de croissance durable ?", les 6 et 7 juin 2013. Université des Antilles et de la Guyane
Description : Il est question ici de la première table ronde de la deuxième journée du forum "Bodlanmè". Il s'agira entre autre, de : - découvrir quelques uns des projets encadrés par OSEO. - prendre connaissance de quelques recherches menées à l'IRD, étant appelées à être valorisée dans le milieu de la mer et du littoral. - tabler sur la relocalisation du secteur industriel en Martinique.
Siècle(s) traité(s) : 21
Droits : CC-BY-NC-ND - Attribution - Pas d'utilisation commerciale - Pas de modification
Permalien : http://www.manioc.org/fichiers/V13206
V13206

Éditeur(s) : HAL CCSD
Résumé : International audience
Background Chlordecone is a persistent organochlorine insecticide with well-defined estrogenic properties. It was intensively used in the French West Indies until 1993 to control the banana root borer. Because of the long-term contamination of soils and water, the population is currently exposed to chlordecone through food consumption. Chlordecone has been found in the blood of pregnant women and in cord blood. It has been shown to be an endocrine-disrupting chemical and exposure during pregnancy may affect fetal growth. Objectives The objective of our study was to examine the association between prenatal exposure to chlordecone and fetal growth based on the TIMOUN birth cohort conducted in Guadeloupe, with a focus on the potential modification of this relationship by maternal body mass index (BMI) and gestational weight gain (GWG). Methods Chlordecone was determined in cord plasma at birth in 593 babies. Birth weight was the indicator of fetal growth. Maternal pre-pregnancy BMI and GWG were determined. Adherence to GWG recommendations of the US Institute of Medicine based on maternal pre-pregnancy BMI was assessed. Birth weight was analyzed relative to cord blood chlordecone levels using linear and non-linear regression models. Results Overall chlordecone in cord blood was not associated with birth weight, but we found an interaction between chlordecone exposure with GWG and adherence to GWG recommendations. After stratification by GWG, we found a significant U-shaped association between birth weight and chlordecone exposure, within the upper quartiles of GWG or excessive GWG. Conclusion Chlordecone exposure may affect fetal growth, particularly when excessive GWG is present. © 2016 Elsevier Inc.
Environmental Research

hal-01367154
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01367154
DOI : 10.1016/j.envres.2016.08.004
PUBMED : 27560981

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
This study analyzes the active tectonics within the northwestern and southeastern extensions of the Pambak-Sevan-Syunik fault (PSSF), a major right-lateral strike-slip fault cutting through Armenia. Quantifying the deformations in terms of geometry, kinematics, slip rates and earthquake activity, using cosmogenic 3He, OSL/IRSL and radiocarbon dating techniques, reveal different behaviors between the two regions. Within the northwestern extension, in the region of Amasia, the PSSF bends to the west and splits into two main WNW–ESE trending reverse faults defining a compressional pop-up structure. We estimate an uplift rate and a shortening rate of 0.5 ± 0.1 mm/y and 1.4 ± 0.6 mm/y, respectively. This suggests that most of the ∼2 mm/y right lateral movement of the PSSF seems to be absorbed within the Amasia pop-structure. Within the southeastern extension, the PSSF shows signs of dying out within the Tsghuk Volcano region at the southernmost tip of the Syunik graben. There, the tectonic activity is characterized by a very slow NS trending normal faulting associated with a slight right-lateral movement. Slip rates analyses (i.e. vertical slip rate, EW stretching rate at 90° to the fault, and right-lateral slip rate of ∼0.2 mm/y, ∼0.1 mm/y and ∼0.05 mm/y, respectively) lead to the conclusion that the right lateral movement observed further north along the PSSF is mainly transferred within other active faults further west within the Karabagh (Hagari fault or other structures further northwestwards). Comparing our slip rates with those estimated from GPS data suggests that most of the deformation is localized and seismic, at least within the Tsghuk region. The geometrical and kinematic pattern observed within the two terminations of the PSSF suggests that the fault and its surrounding crustal blocks are presently rotating anticlockwise, as also observed within the GPS velocity field. This is consistent with the recent kinematic models proposed for the Caucasus-Kura-South Caspian region and brings a new insight into the present geodynamics of Armenia.
ISSN: 1040-6182

hal-01307342
https://hal.archives-ouvertes.fr/hal-01307342
DOI : 10.1016/j.quaint.2015.05.021

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
BACKGROUND & AIMS: Nutrients influence non-alcoholic fatty liver disease. Essential fatty acids deficiency promotes various syndromes, including hepatic steatosis, through increased de novo lipogenesis. The mechanisms underlying such increased lipogenic response remain unidentified. METHODS: We used wild type mice and mice lacking Liver X Receptors to perform a nutrigenomic study that aimed at examining the role of these transcription factors. RESULTS: We showed that, in the absence of Liver X Receptors, essential fatty acids deficiency does not promote steatosis. Consistent with this, Liver X Receptors are required for the elevated expression of genes involved in lipogenesis in response to essential fatty acids deficiency. CONCLUSIONS: This work identifies, for the first time, the central role of Liver X Receptors in steatosis induced by essential fatty acids deficiency.
ISSN: 0168-8278

inserm-00872314
http://www.hal.inserm.fr/inserm-00872314
DOI : 10.1016/j.jhep.2013.01.006
PUBMED : 23333450

Éditeur(s) : HAL CCSD American Geophysical Union (AGU)
Résumé : International audience
[1] Zircons and monazites from 6 samples of the North Ayilari dextral shear zone (NAsz), part of the Karakorum fault zone (KFZ), have been dated with the U-Th-Pb method, using both ID-TIMS and SIMS techniques. The ages reveal (1) inheritance from several events spanning a long period between the late Archean and the Jurassic; (2) an Eocene-Oligocene magmatic event (similar to 35-32 Ma); (3) an Oligo-Miocene magmatic event (similar to 25-22 Ma), at least partly synkinematic to the right-lateral deformation; and (4) a period of metamorphism metasomatism (similar to 22-14 Ma) interpreted as thermal and fluid advection in the shear zone. The Labhar Kangri granite located similar to 375 km farther Southeast along the KFZ is dated at 21.1 +/- 0.3 Ma. Such occurrence of several Oligo-Miocene granites along the KFZ, some of which show evidence for synkinematic emplacement, suggests that the fault zone played an important role in the genesis and /or collection of crustal melts. We discuss several scenarios for the onset and propagation of the KFZ, and offset estimates based on the main sutures zones. Our preferred scenario is an Oligo-Miocene initiation of the fault close to the NA range, and propagation along most of its length prior to similar to 19 Ma. In its southern half, the averaged long-term fault-rate of the KFZ is greater than 8 to 10 mm/a, in good agreement with some shorter-term estimates based on the Indus river course, or Quaternary moraines and geodesy. Our results show the KFZ cannot be considered as a small transient fault but played a major role in the collision history.
ISSN: 0278-7407

hal-00412570
https://hal.archives-ouvertes.fr/hal-00412570
DOI : 10.1029/2007TC002184

Éditeur(s) : HAL CCSD American Geophysical Union (AGU)
Résumé : The role of the Karakorum fault zone (KFZ) is debated. South of 33°N, ongoing dextral-oblique slip along the SW edge of the Gar basin exhumes metamorphic and magmatic rocks of the Ayilari range. Minerals have recorded a continuum of deformation from temperatures >600–400°C down to <250_C. The 40Ar/39Ar ages, the oldest being 21.2 ± 1.0 Ma, yield minimum estimates for the initiation of the KFZ. These are in agreement with the U-Th/Pb ages constraining the onset of deformation at ca 25–22 Ma. Thermochronologic results show slow cooling for the period ca 21– 14 Ma, followed by rapid cooling between 14 and 4 Ma. These data demonstrate that right-lateral motion was in progress in the early Miocene and that shear continued at least until 4 Ma, pointing to >20 Ma of deformation along the fault. Greenschist facies deformation superimposed upon the medium- to high-grade deformation marks a kinematic change from pure dextral to dextral-normal motion associated with the onset of rapid cooling. At the regional scale, the coexistence of transtension in the Gar basin with transpression documented along the Pangong range farther north suggests another example of the ‘‘zipper tectonics'' model developed along the Red River fault. The kinematic shift induced the rise of the Ayilari range starting at 16–12 Ma and the incision of major river courses. The Indus River might have become captive of the relief at this time. The river's 120 km of apparent offset implies dextral motion at a long-term rate of ca 8.5 ± 1.5 mm/yr.
ISSN: 0278-7407

hal-00197561
https://hal.archives-ouvertes.fr/hal-00197561
https://hal.archives-ouvertes.fr/hal-00197561/document
https://hal.archives-ouvertes.fr/hal-00197561/file/Valli_Karakorum_thermochron_Tectonics_07_pre_print.pdf
DOI : 10.1029/2005TC001913

Éditeur(s) : HAL CCSD
Résumé : National audience
Des expériences dans un bassin de 30 m x 30 m ont été réalisées dans l'objectif de caractériser la dynamique d'un courant d'arrachement et les évolutions morphologiques associées. La plage de sable fin (diamètre médian 166 microns) couvrait la largeur du bassin (30 m en longshore ) pour un profil total de 20 m cross-shore . La formation de courants sagittaux a été forcée par une houle frontale (spectre de Jonswap) avec un déficit d'énergie au centre du bassin. Une séquence accrétive complète de plage intermédiaire à simple barre (selon classification de WRIGHT & SHORT, 1984) a été reproduite. La barre s'est progressivement tridimensionnalisée en forme de croissant puis s'est connectée au haut de plage avec la présence de deux chenaux profonds qui se sont ensuite comblés pour obtenir une plage à terrasse au bout de plusieurs dizaines d'heures. L'association des mesures hydrodynamiques et morphodynamiques montre que le comblement des chenaux est alimenté par le haut de plage.
XI èmes Journées Nationales Génie Côtier - Génie Civil
Sables d'Olonne, France

hal-00861953
https://hal.archives-ouvertes.fr/hal-00861953

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
A shallow field experimental site for CO2 injection was established at Maguelone (Languedoc, France), in order to test in an integrated manner a suite of surface and downhole hydrogeophysical monitoring methods. The objective is to improve monitoring of gas transport in the shallow subsurface and to determine the sensitivity of CO2 monitoring systems for leakage detection. The site offers a natural laboratory to study the processes associated with CO2 injection in a clastic and clay-rich context saturated with saline fluids. Prior to CO2 injection, three nitrogen (N2) injections were undertaken in 2012 to measure the site response to neutral gas injection. In 2013, a volume of 111 m3 (mass of 220 kg) of CO2 was injected during 3.5 h at 15 m depth. During each experiment, the gas plumes were successfully detected from pressure monitoring, time-lapse induction logging and downhole resistivity monitoring with dipole–dipole array. Increases in resistivity are attributed to free gas propagation (either N2 or CO2) whereas decreases in resistivity correlate with CO2 dissolution in the pore fluid. Chemical analyses confirm this hypothesis with a decrease in pH and an increase in the concentration of dissolved species in the latter case.
ISSN: 1750-5836

hal-01355943
https://hal.archives-ouvertes.fr/hal-01355943
DOI : 10.1016/j.ijggc.2015.12.005

Éditeur(s) : HAL CCSD
Résumé : This thesis aims to analyze the active tectonics and the seismic hazard for three main cities of NW Iran (Tehran, Tabriz and Zandjan) using morphotectonics and paleoseismology. Within the Tehran capital, we focused our analysis on the Mosha-North Tehran (M-NT) active fault system. Our investigations show that this fault system is mainly dominated by left-lateral faulting. Along the eastern part of the M-NT fault system, we found evidences of at least seven strong (M>7) paleoearthquakes during the past 10 ka (recurrence interval : 1100-1400 yrs). Our study along the central portion of the fault system (in Abali region) suggests that it corresponds probably to the source of the 1830 AD historical earthquake (M=7.1, Io= IX). Within Tabriz region, we studied the SE segment of the North Tabriz fault. We found evidences of at least three strong events, which occurred during the past 33.5 ka. The North Tabriz dextral fault corresponds to the central portion of a fault system (TFS), and contains two fault segments (NW and SE). Our paleoseismological analysis shows a variation of the slip rate, which decreases from NW to SE along the strike-slip fault. The western (Mishu) and eastern (Bozghush) terminations of the fault system correspond to oblique-compression zones. TFS belongs to the eastern portion of a regional fault system (GSKT), linking the active extension within the central part of the collision and the active compression to the East. Finally, we focus on the Zandjan area, where no important historical seismicitiy is recorded. There, based on morphotectonics analysis we discovered a large active fault network, whose southeastern part affects the Zandjan city. To conclude this work, we replace our observations within the general geodynamic framework of the Arabia- Eurasia collision. One of the striking pictures is the occurrence of opposite kinematics along the M-NT (and other range parallel faults within the south Central Alborz) and the North Tabriz fault systems that have the same trend. This shows the rapid variation of the regional stress field in the Northern Iran.
L'objectif de ce mémoire de thèse est l'étude de la tectonique récente et l'évaluation de l'aléa sismique pour trois villes importante, Téhéran, Tabriz et Zandjan, situées dans le nord-ouest de l'Iran. Dans la capitale de l'Iran, Téhéran, nous nous sommes concentrés sur le système de faille active de Mosha-Nord Téhéran. Nos travaux démontrent que ce système est essentiellement décrochant sénestre. Nos analyses paléosismologiques sur la portion est de ce système (dans la vallée de Tar) montrent au minimum les évidences de sept grands événements sismiques (M>7) pendant les derniers 10000 ans (l'intervalle de récurrence est de 1100 à 1400 ans). Les études que nous avons mené dans la partie centrale de ce système (région d'Abali) révèlent qu'il pourrait être la source du dernier événement sismique ayant affecté la ville de Téhéran en 1830 AD. Dans la région de Tabriz, nous nous sommes intéressés au segment SE de la faille décrochante dextre de Nord Tabriz où nous avons trouvé les évidences de trois grands séismes pendant les derniers 33500 ans. Nos études montrent que la faille Nord Tabriz qui est la portion centrale d'un système de faille (TFS) est constituée par deux segments NW et SE dextres. Notre étude paléosismologique suggère une variation de la vitesse qui diminue du NW vers SE le long de ces segments. Les extrémités ouest (Mishu) et est (Bozghush) de ce système correspondent à des zones compressives qui absorbent les déplacements horizontaux sur les segments NW et SE. D'un point de vue général la TFS est une partie d'un système de failles régionales (GSKT) qui relie une zone d'extension active dans la partie centrale de la collision Arabie-Eurasie et une zone de compression active à l'Est. Enfin, à Zandjan qui est une ville située dans une région de lacune sismique, nous avons découvert un important réseau de failles actives. Le tracé sud-est de ce réseau de failles passe par la ville de Zandjan. En conclusion, les localisations et les cinématiques des systèmes de faille étudiés sont discutées dans le cadre géodynamique général de la collision Arabie-Eurasie. On remarquera que la faille majeure de Nord Tabriz qui correspond essentiellement à un décrochement dextre a la même direction NW-SE que les décrochements sénestres présents dans la chaîne de l'Alborz (les failles de : Mosha, Talaghan et Manjil). Cette observation nécessite une variation de la direction de compression entre ces deux régions.
https://tel.archives-ouvertes.fr/tel-00539739

tel-00539739
https://tel.archives-ouvertes.fr/tel-00539739
https://tel.archives-ouvertes.fr/tel-00539739/document
https://tel.archives-ouvertes.fr/tel-00539739/file/thesesoleymani.pdf

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
ISSN: 0264-3707

hal-00680683
https://hal-brgm.archives-ouvertes.fr/hal-00680683
DOI : 10.1016/j.jog.2011.11.010

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : The area of forest plantations is increasing worldwide helping to meet timber demand and protect natural forests. However, with global change, monospecific plantations are increasingly vulnerable to abiotic and biotic disturbances. As an adaption measure we need to move to plantations that are more diverse in genotypes, species, and structure, with a design underpinned by science. TreeDivNet, a global network of tree diversity experiments, responds to this need by assessing the advantages and disadvantages of mixed species plantations. The network currently consists of 18 experiments, distributed over 36 sites and five ecoregions. With plantations 1-15 years old, TreeDivNet can already provide relevant data for forest policy and management. In this paper, we highlight some early results on the carbon sequestration and pest resistance potential of more diverse plantations. Finally, suggestions are made for new, innovative experiments in understudied regions to complement the existing network.
ISSN: 0044-7447

hal-01204232
https://hal.archives-ouvertes.fr/hal-01204232
DOI : 10.1007/s13280-015-0685-1
PRODINRA : 324368
PUBMED : 26264716

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
BACKGROUND: In the context of recent guidelines on invasive candidiasis (IC), how French intensive care units (ICUs) are managing IC? METHODS: This is a prospective observational multicenter cohort study. During 1 year (2012-2013), 87 French ICUs enrolled consecutive patients with suspected or proven IC (SIC or PIC) and receiving systemic antifungal therapy (SAT). Data were collected up to 28 days after inclusion. RESULTS: We studied 835 patients, 291 with PIC and 544 with SIC. At SAT initiation, patients with SIC were significantly more severe (SAPS II 50.1 ± 18.7 vs. 46.2 ± 18.0). Severe sepsis or septic shock prompted to initiate empiric SAT in 70 % of SIC. Within 4 days in median, the initial SAT was modified in 49 % of patients with PIC vs. 33 % patients with SIC. Modifications were most often motivated by mycological results, and de-escalation was the most frequent change. Regarding compliance to IC management guidelines, echinocandin was used for 182 (62.5 %) patients with PIC, and 287 (52.7 %) of those with SIC; central venous catheter was removed in 87 (54.3 %) of patients with candidaemia, and 43 of the remaining patients received echinocandin; and de-escalation was undertaken after 5 days of SAT in 142 patients, after 10 days in 13 patients. As 20.6 % of SIC were secondarily documented, 403/835 (48 %) patients had finally a proven IC. Candida albicans was the main pathogen (65.3 %), then Candida glabrata (15.9 %). The 28-day mortality rates were 40.0 % in candidaemia, 25.4 % in cIAI, and 26.7 % in deep-seated candidiasis. In the overall population of patients with proven IC, four independent prognostic factors were identified: immunosuppression (Odds Ratio (OR) = 1.977: 1.03-3.794 95 % confidence interval (CI), p = 0.04), age (OR = 1.035; 1.017-1.053 95 % CI; p  extless 0.001), SAPS extgreater46 on ICU admission (OR = 2.894; 1.81-4.626 95 % CI; p  extless 0.001), and surgery just before or during ICU stay (OR = 0.473; 0.29-0.77 95 % CI; p  extless 0.001). CONCLUSION: When SAT is initiated in French ICUs, the IC is ultimately proven for 48 % of patients. Empiric SAT is initiated in severely ill ICU patients. The initial SAT is often adapted, with de-escalation to fluconazole when possible. Mortality rate remains high
ISSN: 2110-5820

hal-01259216
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01259216
DOI : 10.1186/s13613-015-0103-7
PUBMED : 26743881

Éditeur(s) : HAL CCSD Météo et Climat
Résumé : International audience
Les risques hydrométéorologiques sont au coeur du programme de recherche HyMeX sur le cycle de l'eau en Méditerranée. HyMeX a pour ambition d'améliorer leur prévision, de mieux connaître leur variabilité à l'échelle pluriannuelle et de renseigner sur leur évolution, dans le contexte du changement climatique. À cette fin, deux campagnes de mesures dédiées à ces événements extrêmes (SOP1 : pluies intenses et crues rapides ; SOP2 : vents forts et formation d'eaux denses) sont organisées en Méditerranée nord-occidentale, entre septembre 2012 et mars 2013.
ISSN: 0026-1181

hal-00829760
https://hal.archives-ouvertes.fr/hal-00829760
DOI : 10.4267/2042/48793

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The Zandjan province is situated in the NW of Iran, at the junction between the southern termination of the Tabriz right-lateral strike-slip fault and the western end of the Alborz active mountain range. Despite this key location, in terms of active tectonics, there is no destructive earthquake reported in available historical seismicity catalogues. Even if a few low magnitude instrumental earthquakes have been recorded indicating that this area is actively deforming, the Zandjan region can be considered as a seismic gap. Based on detailed field investigations, digital elevation models (DEMs), satellite image and aerial photo interpretations, we have identified a major active fault network affecting this regions. It is mainly constituted by several west and est verging thrust faults, trending NW-SE to N-S, that clearly cut Late Quaternary to Holocene deposits. Evidences in the morphology indicate also that they accommodate some right-lateral slip component. This fault network can be divided into four major fault zones affecting Zandjan city (present day population over 500,000) and part of the Zandjan-Mianeh basin more to the west. Based on fault geometrical characteristics (fault length, segmentation ... ) and kinematics, the Zandjan fault system is certainly capable to produce moderate to large earthquakes (Mw = 6.5-7.0) and serious damages in the Zandjan city and surrounding areas. The study of these faults is, then, of major interest for seismic hazard assessment in Zandjan province where total population exceed 1.5 million but also to better understand present day geodynamic of NW Iran.
ISSN: 0040-1951

hal-00617526
https://hal.archives-ouvertes.fr/hal-00617526
DOI : 10.1016/j.tecto.2011.04.012

Éditeur(s) : HAL CCSD Météo et Climat
Résumé : International audience
D'initiative française, le projet international HyMeX a pour objectif d'améliorer la compréhension du cycle de l'eau en Méditerranée, de sa variabilité, de l'échelle de l'événement météorologique aux échelles saisonnières et interannuelles, et de ses caractéristiques sur une décennie, dans un contexte de changement global. Le projet est motivé par le rôle déterminant des processus de mésoéchelle, couplés entre l'atmosphère, la mer et la terre, sur la variabilité du système climatique et sur le déclenchement d'événements hydrométéorologiques extrêmes (précipitations et inondations, vents forts et convection océanique, canicules et sécheresses). Le projet vise enfin à évaluer les conséquences de ces événements extrêmes sur la vulnérabilité sociale et économique de cette région et sa capacité d'adaptation.
ISSN: 0026-1181

hal-00828758
https://hal.archives-ouvertes.fr/hal-00828758
https://hal.archives-ouvertes.fr/hal-00828758/document
https://hal.archives-ouvertes.fr/hal-00828758/file/meteo_2013_80_23%20%281%29.pdf
DOI : 10.4267/2042/48792

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Resolving the early diversification of animal lineages has proven difficult, even using genome-scale datasets. Several phylogenomic studies have supported the classical scenario in which sponges (Porifera) are the sister group to all other animals (''Porifera-sister''3 hypothesis), consistent with a single origin of the gut, nerve cells, and muscle cells in the stem lineage of eumetazoans (bilaterians + ctenophores + cnidarians). In contrast, several other studies have recovered an alternative topology in which ctenophores are the sister group to all other animals (including sponges). The ``Ctenophora-sister'' hypothesis implies that eumetazoan-specific traits, such as neurons and muscle cells, either evolved once along the metazoan stem lineage and were then lost in sponges and placozoans or evolved at least twice independently in Ctenophora and in Cnidaria + Bilateria. Here, we report on our reconstruction of deep metazoan relationships using a 1,719-gene dataset with dense taxonomic sampling of non-bilaterian animals that was assembled using a semi-automated procedure, designed to reduce known error sources. Our dataset outperforms previous metazoan gene superalignments in terms of data quality and quantity. Analyses with a best-fitting site-heterogeneous evolutionary model provide strong statistical support for placing sponges as the sister-group to all other metazoans, with ctenophores emerging as the second-earliest branching animal lineage. Only those methodological settings that exacerbated long-branch attraction artifacts yielded Ctenophora-sister. These results show that methodological issues must be carefully addressed to tackle difficult phylogenetic questions and pave the road to a better understanding of how fundamental features of animal body plans have emerged.
ISSN: 0960-9822

hal-01681528
https://hal.archives-ouvertes.fr/hal-01681528
DOI : 10.1016/j.cub.2017.02.031

Éditeur(s) : HAL CCSD
Résumé : This work addresses a study of geodynamics in Armenia, a country located in the central part of the zone of continental collision between the Arabian and Eurasian lithosphere plates. The work includes two main parts: study of recent deformations of the lithosphere by means of GPS and detailed paleoseismological and morphometric investigations in the zone of the Artanish-Tskhouk segment of the PSSF. We analyze and compare rates of deformation determined by the GPS data and the rates estimated by the paleoseismological and morphometric studies. The Armenian-French network of GPS observations was installed in Armenia in 1998. Three observation sessions were conducted in 1998, 2000 and 2003. Based on the evidence obtained, a detailed study of the velocity field was conducted to analyze lithosphere deformation in Central and Northern Armenia. Slip rates were estimated for the principal active faults in Armenia. Several field works, including paleoseismological, archaeo-seismological, archaeological, geodetic and morphological studies, had been implemented in the zone of the Artanish-Tskhouk segment of the PSSF in 2003-2005. The fault was mapped in detail; rates of main horizontal and vertical slip along the fault were estimated and re-estimated. Four (4) paleo- and archeo-earthquakes were studied and dated. Eventually, the obtained data allowed us to re-estimate slip rates, maximum possible magnitudes and recurrence intervals of strong earthquakes on the Artanish-Tskhouk segment of the PSSF. A technique enabling estimation of horizontal and vertical displacements along strike-slip faults during paleo-earthquakes by the evidence obtained from paleo-seismological trenching was developed.
Les travaux présentés dans ce mémoire sont consacrés à l'étude de la géodynamique du territoire de l'Arménie qui est situé dans la partie centrale de la zone de collision continentale entre les plaques Arabique et Eurasienne. Le mémoire comprend deux parties principales: 1/ l'étude des déformations actuelles par la géodésie GPS; 2/ l'étude paléosismologique et morphométrique détaillée de la zone du segment d'Artanish-Tskhuk de la faille de Pambak-Sevan-Syunik (PSSF). On présente l'analyse et la comparaison des vitesses de déformations estimées par les données de GPS et par les données paléosismologiques et morphométriques. Le réseau d'observations GPS Arméno - Français a été installé en Arménie en septembre 1998. Trois campagnes de mesure du réseau ont été réalisées en 1998, 2000 et 2003. L'analyse détaillée du champ de vitesse à partir des données GPS a permis d'étudier et de quantifier les déformations actuelles de l'Arménie centrale et septentrionale. On a pu estimer les vitesses des déplacements des failles actives principales du territoire de l'Arménie. Un ensemble de travaux sur le terrain comprenant des recherches paléosismologiques, archéosismologiques, archéologiques, géodésiques, et morphologiques a été réalisé entre 2003 et 2005 dans la zone du segment d'Artanish-Tskhuk de la faille de PSSF. La cartographie détaillée de la faille a été réalisée et l'on a estimé et/ou re-estimés les déplacements horizontaux et verticaux le long de la faille. Quatre paléo- et archéoséismes ont été étudiés et datés. À partir des données obtenues, pour le segment d'Artanish-Tskhuk de la faille de PSSF, on a réévalué les vitesses de déplacements, la magnitude maximale possible, et l'intervalle récurrence des séismes forts. Une méthode d'évaluation des déplacements horizontaux et verticaux a été proposée à partir des logs de tranchées sur les failles de décrochements associées à des paléoséismes.
https://tel.archives-ouvertes.fr/tel-00551535

Droits : info:eu-repo/semantics/OpenAccess
tel-00551535
https://tel.archives-ouvertes.fr/tel-00551535
https://tel.archives-ouvertes.fr/tel-00551535/document
https://tel.archives-ouvertes.fr/tel-00551535/file/thesedavtyan2.pdf

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
o abstract
ISSN: 0735-1097

hal-01446568
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01446568
DOI : 10.1016/j.jacc.2016.09.036
PUBMED : 27970295

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The influence of redox alteration on the growth and proteomic pattern of Listeria monocytogenes was investigated. A redox shock was induced in cultures by addition of 3mM ferricyanide (FeCN) and 6mM dithiothreitol (DTT) to increase or to decrease respectively the redox potential naturally occurring at the beginning of growth. In both conditions, the reducing and oxidizing redox shock had a strong influence, decreasing the maximum growth rate by half compared to a control culture. The proteomic analysis of L. monocytogenes performed by two-dimensional difference gel electrophoresis (2D-DIGE) exhibited twenty-three proteins differentially expressed (P<0.05), among these, many were oxidoreductases, and proteins involved in cellular metabolism (glycolysis, protein synthesis), detoxification (kat) or adhesion (Lmo1634).
ISSN: 1874-3919

hal-00877138
https://hal-univ-rennes1.archives-ouvertes.fr/hal-00877138
DOI : 10.1016/j.jprot.2012.11.010
PUBMED : 23195917

Éditeur(s) : HAL CCSD American Society for Biochemistry and Molecular Biology
Résumé : International audience
Polycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene (B(a)P) are widely distributed environmental contaminants, known as potent ligands of the aryl hydrocarbon receptor (AhR). These chemicals trigger an early and transient increase of intracellular calcium concentration ([Ca(2+)](i)), required for AhR-related effects of PAHs. The mechanisms involved in this calcium mobilization were investigated in the present study. We demonstrated that B(a)P-mediated [Ca(2+)](i) induction was prevented in endothelial HMEC-1 cells by counteracting β2-adrenoreceptor (β2ADR) activity using pharmacological antagonists, anti-β2ADR antibodies, or siRNA-mediated knockdown of β2ADR expression; by contrast, it was strongly potentiated by β2ADR overexpression in human kidney HEK293 cells. B(a)P was shown, moreover, to directly bind to β2ADR, as assessed by in vitro binding assays and molecular modeling. Pharmacological inhibition and/or siRNA-mediated silencing of various signaling actors acting downstream of β2ADR in a sequential manner, such as G protein, adenylyl cyclase, Epac-1 protein, and inositol 1,4,5-trisphosphate (IP(3))/IP(3) receptor, were next demonstrated to prevent B(a)P-induced calcium signal. Inhibition or knockdown of these signaling elements, as well as the use of chemical β-blockers, were finally shown to counteract B(a)P-mediated induction of cytochrome P-450 1B1, a prototypical AhR target gene. Taken together, our results show that B(a)P binds directly to β2ADR and consequently utilizes β2ADR machinery to mobilize [Ca(2+)](i), through activation of a G protein/adenylyl cyclase/cAMP/Epac-1/IP(3) pathway. This β2ADR-dependent signaling pathway activated by PAHs may likely be crucial for PAH-mediated up-regulation of AhR target genes, thus suggesting a contribution of β2ADR to the health-threatening effects of these environmental pollutants.
ISSN: 0021-9258

hal-00682497
https://hal.archives-ouvertes.fr/hal-00682497
DOI : 10.1074/jbc.M111.319970
PUBMED : 22167199